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David Loegering

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Chemicals & Drugs

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Thomas E Witzig; Cristine Allmer; Stephen M Ansell; Joseph P Colgan; Husheng Ding; Mamta Gupta; Thomas M Habermann; Ray Hohl; David J Inwards; Patrick B Johnston; Paul J Kurtin; Brian K Link; David Loegering; Svetomir N Markovic; Matthew J Maurer; Ivana N M Micallef; Grzegorz S Nowakowski; Kevin Peterson; Luis F Porrata; Paula Schneider; Hui Tang; Carrie A Thompson; George Weiner; Scott H Kaufmann
Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas.
Xue Wei Meng; Michael P Heldebrant; Karen Flatten; David Loegering; Haiming Dai; Paula A Schneider; Timothy Gomez; Kevin L Peterson; Sergey A Trushin; Allan Hess; B Douglas Smith; Judith E Karp; Daniel D Billadeau; Scott H Kaufmann
Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
Andrea E Wahner Hendrickson; Paul Haluska; Paula A Schneider; David Loegering; Kevin L Peterson; Ricardo M Attar; B Douglas Smith; Charles Erlichman; Marco Gottardis; Judith E Karp; Joan M Carboni; Scott H Kaufmann
Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro.

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All Publications

2011: Thomas E Witzig; Cristine Allmer; Stephen M Ansell; Joseph P Colgan; Husheng Ding; Mamta Gupta; Thomas M Habermann; Ray Hohl; David J Inwards; Patrick B Johnston; Paul J Kurtin; Brian K Link; David Loegering; Svetomir N Markovic; Matthew J Maurer; Ivana N M Micallef; Grzegorz S Nowakowski; Kevin Peterson; Luis F Porrata; Paula Schneider; Hui Tang; Carrie A Thompson; George Weiner; Scott H Kaufmann
Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas.
Blood 2011;118(18):4882-9.
2010: Xue Wei Meng; Michael P Heldebrant; Karen Flatten; David Loegering; Haiming Dai; Paula A Schneider; Timothy Gomez; Kevin L Peterson; Sergey A Trushin; Allan Hess; B Douglas Smith; Judith E Karp; Daniel D Billadeau; Scott H Kaufmann
Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.
The Journal of biological chemistry 2010;285(2):888-902.
2009: Andrea E Wahner Hendrickson; Paul Haluska; Paula A Schneider; David Loegering; Kevin L Peterson; Ricardo M Attar; B Douglas Smith; Charles Erlichman; Marco Gottardis; Judith E Karp; Joan M Carboni; Scott H Kaufmann
Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro.
Cancer research 2009;69(19):7635-43.
2008: Marina Gálvez-Peralta; Nga T Dai; David Loegering; Karen Flatten; Stephanie L Safgren; Jill M Wagner; Matthew M Ames; Larry M Karnitz; Scott H Kaufmann
Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines.
Molecular pharmacology 2008;74(3):724-35.
2008: Jennifer S Hackbarth; Marina Galvez-Peralta; Nga T Dai; David Loegering; Kevin L Peterson; Xue W Meng; Larry M Karnitz; Scott H Kaufmann
Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I.
The Journal of biological chemistry 2008;283(24):16711-22.
2008: Scott H Kaufmann; Sun-Hee Lee; X Wei Meng; David Loegering; Timothy J Kottke; Alexander J Henzing; Sandrine Ruchaud; Kumiko Samejima; William C Earnshaw
Apoptosis-associated caspase activation assays.
Methods (San Diego, Calif.) 2008;44(3):262-72.
2007: Xue Wei Meng; Sun-Hee Lee; Haiming Dai; David Loegering; Chunrong Yu; Karen Flatten; Paula Schneider; Nga T Dai; Shaji Kumar; B Douglas Smith; Judith E Karp; Alex A. Adjei; Scott H Kaufmann
Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.
The Journal of biological chemistry 2007;282(41):29831-46.
2006: Douglas A Plager; David Loegering; James L Checkel; Junger Tang; Gail M Kephart; Patricia L Caffes; Cheryl R Adolphson; Lyo E Ohnuki; Gerald J Gleich
Major basic protein homolog (MBP2): a specific human eosinophil marker.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7340-5.
2006: Ruben A Mesa; Ayalew Tefferi; T S Lasho; David Loegering; Rebecca F McClure; Heather L Powell; Nga T Dai; David P Steensma; Scott H Kaufmann
Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia.
Leukemia 2006;20(10):1800-8.
2006: Joya Chandra; Jeannette Tracy; David Loegering; Karen Flatten; Srdan Verstovsek; Miloslav Beran; Mercedes Gorre; Zeev Estrov; Nicholas J Donato; Moshe Talpaz; Charles L Sawyers; Kapil N Bhalla; Judith E Karp; Edward A Sausville; Scott H Kaufmann
Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance.
Blood 2006;107(6):2501-6.
2006: David Loegering; S Ruchaud; W C Earnshaw; S H Kaufmann
Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis.
Cell death and differentiation 2006;13(2):346-7.
2006: Paul Haluska; Joan M Carboni; David Loegering; Francis Y Lee; Mark Wittman; Mark G Saulnier; David B Frennesson; Kimberly R Kalli; Cheryl A Conover; Ricardo M Attar; Scott H Kaufmann; Marco Gottardis; Charles Erlichman
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.
Cancer research 2006;66(1):362-71.
2005: Lyo E Ohnuki; Lori A Wagner; Ann Georgelas; David Loegering; James L Checkel; Douglas A Plager; Gerald J Gleich
Differential extraction of eosinophil granule proteins.
Journal of immunological methods 2005;307(1-2):54-61.
2005: Larry M Karnitz; Karen Flatten; Jill M Wagner; David Loegering; Jennifer S Hackbarth; Sonnet J H Arlander; Ben Vroman; M Bijoy Thomas; Yong-Un Baek; Kevin M Hopkins; Howard B Lieberman; Junjie Chen; William A Cliby; Scott H Kaufmann
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.
Molecular pharmacology 2005;68(6):1636-44.
2005: Scott H Kaufmann; Judith E Karp; Louis Letendre; Timothy J Kottke; Stephanie L Safgren; Jacqueline Greer; Ivana Gojo; Pamela J Atherton; Phyllis A Svingen; David Loegering; Mark R Litzow; Jeff A Sloan; Joel M Reid; Matthew M Ames; Alex A. Adjei; Charles Erlichman
Phase I and pharmacologic study of infusional topotecan and Carboplatin in relapsed and refractory acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6641-9.
2005: Ruben A Mesa; David Loegering; Heather L Powell; Karen Flatten; Sonnet J H Arlander; Nga T Dai; Michael P Heldebrant; Ben Vroman; B Douglas Smith; Judith E Karp; Cynthia J Ten Eyck; Charles Erlichman; Scott H Kaufmann; Larry M Karnitz
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
Blood 2005;106(1):318-27.
2005: Irene M Ghobrial; Daniel J McCormick; Scott H Kaufmann; Alexey A Leontovich; David Loegering; Nga T Dai; Kelly L Krajnik; Mary J Stenson; Mona F Melhem; Anne J Novak; Stephen M Ansell; Thomas E Witzig
Proteomic analysis of mantle-cell lymphoma by protein microarray.
Blood 2005;105(9):3722-30.
2005: Karen Flatten; Nga T Dai; Ben Vroman; David Loegering; Charles Erlichman; Larry M Karnitz; Scott H Kaufmann
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.
The Journal of biological chemistry 2005;280(14):14349-55.
2004: Phyllis A Svingen; David Loegering; Joe Rodriquez; Xue Wei Meng; Peter W Mesner; Susan Holbeck; Anne Monks; Stan Krajewski; Dominic A Scudiero; Edward A Sausville; John C Reed; Yuri A Lazebnik; Scott H Kaufmann
Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6807-20.
2004: David Loegering; Sonnet J H Arlander; Jennifer S Hackbarth; Ben Vroman; Pia Roos-Mattjus; Kevin M Hopkins; Howard B Lieberman; Larry M Karnitz; Scott H Kaufmann
Rad9 protects cells from topoisomerase poison-induced cell death.
The Journal of biological chemistry 2004;279(18):18641-7.
2004: Nadia Korfali; Sandrine Ruchaud; David Loegering; Delphine Bernard; Colin Dingwall; Scott H Kaufmann; William C Earnshaw
Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.
The Journal of biological chemistry 2004;279(2):1030-9.
2003: Joya Chandra; Jennifer S Hackbarth; Son B Le; David Loegering; Nancy D Bone; Laura M Bruzek; Ven L Narayanan; Alex A. Adjei; Neil E Kay; Ayalew Tefferi; Judith E Karp; Edward A Sausville; Scott H Kaufmann
Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.
Blood 2003;102(13):4512-9.
2003: Xue Wei Meng; Joya Chandra; David Loegering; Keri Van Becelaere; Timothy J Kottke; Steven D Gore; Judith E Karp; Judith Leopold; Scott H Kaufmann
Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro.
The Journal of biological chemistry 2003;278(47):47326-39.
2003: Kenneth L Johnson; David Loegering; Gerald J Gleich; Stephen Naylor
A modular on-line three-dimensional liquid chromatography-tandem mass spectrometry approach to characterization of organelle proteomes.
Biomedical chromatography : BMC 2003;17(2-3):106-12.
2001: Ganesh Jawahar Swaminathan; A J Weaver; David Loegering; James L Checkel; Demetres Leonidas; Gerald J Gleich; K Ravi Acharya
Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity.
The Journal of biological chemistry 2001;276(28):26197-203.
2001: Douglas A Plager; Deborah Weiler; David Loegering; W B Johnson; LL Haley; RL Eddy; TB Shows; Gerald J Gleich
Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes.
Genomics 2001;71(3):271-81.
1999: H Nakajima; David Loegering; Hirohito Kita; Gail M Kephart; Gerald J Gleich
Reactivity of monoclonal antibodies EG1 and EG2 with eosinophils and their granule proteins.
Journal of leukocyte biology 1999;66(3):447-54.
1999: H Kubo; David Loegering; Y Tohda; Jennifer L Bankers-Fulbright; C R Weiler; H Nakajima; Larry L Thomas; Cheryl R Adolphson; Gerald J Gleich
Discordant and anomalous results among cytotoxicity assays: the confounding properties of eosinophil granule major basic protein on cell viability assays.
Journal of immunological methods 1999;227(1-2):1-15.
1999: Douglas A Plager; David Loegering; Deborah Weiler; James L Checkel; JM Wagner; N J Clarke; Stephen Naylor; SM Page; Larry L Thomas; I Akerblom; B Cocks; S Stuart; Gerald J Gleich
A novel and highly divergent homolog of human eosinophil granule major basic protein.
The Journal of biological chemistry 1999;274(20):14464-73.
1999: H Kubo; David Loegering; Cheryl R Adolphson; Gerald J Gleich
Cytotoxic properties of eosinophil granule major basic protein for tumor cells.
International archives of allergy and immunology 1999;118(2-4):426-8.
1998: P Popken-Harris; James L Checkel; David Loegering; B Madden; Margaret Springett; Gail M Kephart; Gerald J Gleich
Regulation and processing of a precursor form of eosinophil granule major basic protein (ProMBP) in differentiating eosinophils.
Blood 1998;92(2):623-31.
1998: Jennifer L Bankers-Fulbright; Gail M Kephart; David Loegering; A L Bradford; Shinji Okada; Hirohito Kita; Gerald J Gleich
Sulfonylureas inhibit cytokine-induced eosinophil survival and activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5546-53.
1995: P Popken-Harris; M McGrogan; David Loegering; J L Checkel; H Kubo; Larry L Thomas; J N Moy; Lars Sottrup-Jensen; J L Snable; M T Kikuchi
Expression, purification, and characterization of the recombinant proform of eosinophil granule major basic protein.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1472-80.
1994: M Bonno; Gail M Kephart; C M Carlson; David Loegering; K K Vernof; G J Gleich
Expression of eosinophil-granule major basic protein messenger ribonucleic acid in placental X cells.
Laboratory investigation; a journal of technical methods and pathology 1994;70(2):234-41.
1992: R I Abu-Ghazaleh; S L Dunnette; David Loegering; J L Checkel; H Kita; Larry L Thomas; G J Gleich
Eosinophil granule proteins in peripheral blood granulocytes.
Journal of leukocyte biology 1992;52(6):611-8.
1992: Salvatore Sorrentino; D G Glitz; Kimm Hamann; David Loegering; J L Checkel; G J Gleich
Eosinophil-derived neurotoxin and human liver ribonuclease. Identity of structure and linkage of neurotoxicity to nuclease activity.
The Journal of biological chemistry 1992;267(21):14859-65.
1991: R L Barker; R H Gundel; G J Gleich; J L Checkel; David Loegering; Larry R Pease; Kimm Hamann
Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity. Evidence of a functional role for ProMBP.
The Journal of clinical investigation 1991;88(3):798-805.
1990: Kimm Hamann; R M Ten; David Loegering; Robert B Jenkins; M T Heise; C R Schad; Larry R Pease; G J Gleich; R L Barker
Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.
Genomics 1990;7(4):535-46.
1990: Kimm Hamann; G J Gleich; J L Checkel; David Loegering; J W McCall; R L Barker
In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):3166-73.
1990: R L Barker; David Loegering; K C Arakawa; Larry R Pease; G J Gleich
Cloning and sequence analysis of the human gene encoding eosinophil major basic protein.
Gene 1990;86(2):285-9.
1989: Stephen R Durham; David Loegering; S Dunnette; G J Gleich; A Barry Kay
Blood eosinophils and eosinophil-derived proteins in allergic asthma.
The Journal of allergy and clinical immunology 1989;84(6 Pt 1):931-6.
1989: Kimm Hamann; R L Barker; David Loegering; Larry R Pease; G J Gleich
Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases.
Gene 1989;83(1):161-7.
1989: R L Barker; David Loegering; R M Ten; Kimm Hamann; Larry R Pease; G J Gleich
Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):952-5.
1989: S Motojima; E Frigas; David Loegering; G J Gleich
Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro.
The American review of respiratory disease 1989;139(3):801-5.
1988: T L Wasmoen; Michael P Bell; David Loegering; G J Gleich; F G Prendergast; David J McKean
Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein.
The Journal of biological chemistry 1988;263(25):12559-63.
1987: Kimm Hamann; R L Barker; David Loegering; G J Gleich
Comparative toxicity of purified human eosinophil granule proteins for newborn larvae of Trichinella spiralis.
The Journal of parasitology 1987;73(3):523-9.
1986: G J Gleich; David Loegering; Michael P Bell; J L Checkel; Steven J Ackerman; David J McKean
Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3146-50.
1985: G J Gleich; David Loegering; Cheryl R Adolphson
Eosinophils and bronchial inflammation.
Chest 1985;87(1 Suppl):10S-13S.
1983: G J Gleich; David Loegering; E Frigas; W V Filley
The eosinophil granule major basic protein: biological activities and relationship to bronchial asthma.
Monographs in allergy 1983;18():277-83.
1981: E Frigas; David Loegering; G O Solley; G M Farrow; G J Gleich
Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma.
Mayo Clinic proceedings. Mayo Clinic 1981;56(6):345-53.
1980: E Frigas; David Loegering; G J Gleich
Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium.
Laboratory investigation; a journal of technical methods and pathology 1980;42(1):35-43.