Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Richard Loeser

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Disorders

Chemicals & Drugs

Living Beings

Macaca fascicularis

Procedures

Exercise Therapy

Physiology

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
10
Messier, Stephen
9
Im, Hee-Jeong
8
Carlson, Cathy
7
Miller, Gary
5
Nicklas, Barbara
5
Wallin, Reidar
5
Chubinskaya, Susan
5
Del Carlo, Marcello
4
Williamson, Jeff
4
Rejeski, Jack
4
Yammani, Raghunatha
4
Pacione, Carol
3
Pulai, Judit
3
Shanker, Gouri
3
Sonntag, William

Sign-in to see all Coauthors

Publications

TOP 3
Yin Weihong; Park Jong-In; Loeser Richard F
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.
Loeser R F
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.
Loeser R F; Im H-J; Richardson B; Lu Q; Chubinskaya S
Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Richard Loeser (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Yin Weihong; Park Jong-In; Loeser Richard F
Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.
The Journal of biological chemistry 2009;284(46):31972-81.
2009: Loeser R F
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(8):971-9.
2009: Loeser R F; Im H-J; Richardson B; Lu Q; Chubinskaya S
Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(4):513-7.
2009: Yammani Raghunatha R; Long David; Loeser Richard F
Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
Arthritis and rheumatism 2009;60(3):792-800.
2009: Cravero John D; Carlson Cathy S; Im Hee-Jeong; Yammani Raghunatha R; Long David; Loeser Richard F
Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.
Arthritis and rheumatism 2009;60(2):492-500.
2009: Messier Stephen P; Legault Claudine; Mihalko Shannon; Miller Gary D; Loeser Richard F; DeVita Paul; Lyles Mary; Eckstein Felix; Hunter David J; Williamson Jeff D; Nicklas Barbara J
The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale.
BMC musculoskeletal disorders 2009;10():93.
2008: Loeser Richard F; Erickson Elizabeth A; Long David L
Mitogen-activated protein kinases as therapeutic targets in osteoarthritis.
Current opinion in rheumatology 2008;20(5):581-6.
2008: Chua S D; Messier S P; Legault C; Lenz M E; Thonar E J-M A; Loeser R F
Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(9):1047-53.
2008: Miller Gary D; Nicklas Barbara J; Loeser Richard F
Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy.
Journal of the American Geriatrics Society 2008;56(4):644-51.
2008: Del Carlo Marcello; Loeser Richard F
Cell death in osteoarthritis.
Current rheumatology reports 2008;10(1):37-42.
2008: Long David; Blake Simon; Song Xiao-Yu; Lark Michael; Loeser Richard F
Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13.
Arthritis research & therapy 2008;10(1):R23.
2007: Messier S P; Mihalko S; Loeser R F; Legault C; Jolla J; Pfruender J; Prosser B; Adrian A; Williamson J D
Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(11):1256-66.
2007: Del Carlo Marcello; Schwartz Daniel; Erickson Elizabeth A; Loeser Richard F
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments.
Free radical biology & medicine 2007;42(9):1350-8.
2007: Im Hee-Jeong; Muddasani Prasuna; Natarajan Viswanathan; Schmid Thomas M; Block Joel A; Davis Francesca; van Wijnen Andre J; Loeser Richard F
Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes.
The Journal of biological chemistry 2007;282(15):11110-21.
2007: Chubinskaya S; Hakimiyan A; Pacione C; Yanke A; Rappoport L; Aigner T; Rueger D C; Loeser R F
Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(4):421-30.
2006: Ekenstedt Kari J; Sonntag William E; Loeser Richard F; Lindgren Bruce R; Carlson Cathy S
Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints.
Arthritis and rheumatism 2006;54(12):3850-8.
2006: Yammani Raghunatha R; Carlson Cathy S; Bresnick Anne R; Loeser Richard F
Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.
Arthritis and rheumatism 2006;54(9):2901-11.
2006: Miller Gary D; Nicklas Barbara J; Davis Cralen; Loeser Richard F; Lenchik Leon; Messier Stephen P
Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis.
Obesity (Silver Spring, Md.) 2006;14(7):1219-30.
2006: DelCarlo Marcello; Loeser Richard F
Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI.
American journal of physiology. Cell physiology 2006;290(3):C802-11.
2005: Loeser Richard F; Chubinskaya Susan; Pacione Carol; Im Hee-Jeong
Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes.
Arthritis and rheumatism 2005;52(12):3910-7.
2005: Forsyth Christopher B; Cole Ada; Murphy Gillian; Bienias Julia L; Im Hee-Jeong; Loeser Richard F
Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(9):1118-24.
2005: Loeser Richard F; Yammani Raghunatha R; Carlson Cathy S; Chen Hong; Cole Ada; Im Hee-Jeong; Bursch Laura S; Yan Shi Du
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.
Arthritis and rheumatism 2005;52(8):2376-85.
2005: Starkman Bela G; Cravero John D; Delcarlo Marcello; Loeser Richard F
IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.
The Biochemical journal 2005;389(Pt 3):723-9.
2005: Sonntag William E; Carter Christy S; Ikeno Yuji; Ekenstedt Kari; Carlson Cathy S; Loeser Richard F; Chakrabarty Shilla; Lee Shuko; Bennett Colleen; Ingram Rhonda; Moore Tracy; Ramsey Melinda
Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span.
Endocrinology 2005;146(7):2920-32.
2005: Pulai Judit I; Chen Hong; Im Hee-Jeong; Kumar Sanjay; Hanning Charles; Hegde Priti S; Loeser Richard F
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5781-8.
2004: Miller G D; Nicklas B J; Davis C C; Ambrosius W T; Loeser R F; Messier S P
Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(11):1383-90.
2004: Shakoor Najia; Loeser Richard F
Osteoarthritis.
Science of aging knowledge environment : SAGE KE 2004;2004(35):dn2.
2004: Loeser Richard F
Aging cartilage and osteoarthritis--what's the link?
Science of aging knowledge environment : SAGE KE 2004;2004(29):pe31.
2004: Messier Stephen P; Loeser Richard F; Miller Gary D; Morgan Timothy M; Rejeski W Jack; Sevick Mary Ann; Ettinger Walter H; Pahor Marco; Williamson Jeff D
Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial.
Arthritis and rheumatism 2004;50(5):1501-10.
2004: Nicklas Barbara J; Ambrosius Walter; Messier Stephen P; Miller Gary D; Penninx Brenda W J H; Loeser Richard F; Palla Shana; Bleecker Eugene; Pahor Marco
Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.
The American journal of clinical nutrition 2004;79(4):544-51.
2004: Ham K D; Oegema T R; Loeser R F; Carlson C S
Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus monkeys.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(2):160-8.
2003: Carlo Marcello Del; Loeser Richard F
Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels.
Arthritis and rheumatism 2003;48(12):3419-30.
2003: Loeser Richard F; Shakoor Najia
Aging or osteoarthritis: which is the problem?
Rheumatic diseases clinics of North America 2003;29(4):653-73.
2003: Loeser Richard F; Pacione Carol A; Chubinskaya Susan
The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes.
Arthritis and rheumatism 2003;48(8):2188-96.
2003: Miller Gary D; Rejeski W Jack; Williamson Jeff D; Morgan Timothy; Sevick Mary Ann; Loeser Richard F; Ettinger Walt H; Messier Stephen P;
The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results.
Controlled clinical trials 2003;24(4):462-80.
2003: Im Hee-Jeong; Pacione Carol; Chubinskaya Susan; Van Wijnen Andre J; Sun Yubo; Loeser Richard F
Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.
The Journal of biological chemistry 2003;278(28):25386-94.
2003: Loeser Richard F; Forsyth Christopher B; Samarel Allen M; Im Hee-Jeong
Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.
The Journal of biological chemistry 2003;278(27):24577-85.
2003: Kurtis Melissa S; Schmidt Tannin A; Bugbee William D; Loeser Richard F; Sah Robert L
Integrin-mediated adhesion of human articular chondrocytes to cartilage.
Arthritis and rheumatism 2003;48(1):110-8.
2002: Forsyth Christopher B; Pulai Judit; Loeser Richard F
Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes.
Arthritis and rheumatism 2002;46(9):2368-76.
2002: Loeser Richard F; Carlson Cathy S; Del Carlo Marcello; Cole Ada
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
Arthritis and rheumatism 2002;46(9):2349-57.
2002: Ham Kimberley D; Loeser Richard F; Lindgren Bruce R; Carlson Cathy S
Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys.
Arthritis and rheumatism 2002;46(7):1956-64.
2002: Pulai Judit I; Del Carlo Marcello; Loeser Richard F
The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro.
Arthritis and rheumatism 2002;46(6):1528-35.
2002: Del Carlo Marcello; Loeser Richard F
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species.
Arthritis and rheumatism 2002;46(2):394-403.
2002: Knudson W; Loeser R F
CD44 and integrin matrix receptors participate in cartilage homeostasis.
Cellular and molecular life sciences : CMLS 2002;59(1):36-44.
2002: Loeser Richard F
Integrins and cell signaling in chondrocytes.
Biorheology 2002;39(1-2):119-24.
2001: Kurtis M S; Tu B P; Gaya O A; Mollenhauer J; Knudson W; Loeser R F; Knudson C B; Sah R L
Mechanisms of chondrocyte adhesion to cartilage: role of beta1-integrins, CD44, and annexin V.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(6):1122-30.
2001: Miller M E; Rejeski W J; Messier S P; Loeser R F
Modifiers of change in physical functioning in older adults with knee pain: the Observational Arthritis Study in Seniors (OASIS).
Arthritis and rheumatism 2001;45(4):331-9.
2000: Wallin R; Cain D; Hutson S M; Sane D C; Loeser R
Modulation of the binding of matrix Gla protein (MGP) to bone morphogenetic protein-2 (BMP-2).
Thrombosis and haemostasis 2000;84(6):1039-44.
2000: Loeser R F; Shanker G; Carlson C S; Gardin J F; Shelton B J; Sonntag W E
Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
Arthritis and rheumatism 2000;43(9):2110-20.
2000: Richmond R S; Carlson C S; Register T C; Shanker G; Loeser R F
Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2.
Arthritis and rheumatism 2000;43(9):2081-90.
2000: Messier S P; Loeser R F; Mitchell M N; Valle G; Morgan T P; Rejeski W J; Ettinger W H
Exercise and weight loss in obese older adults with knee osteoarthritis: a preliminary study.
Journal of the American Geriatrics Society 2000;48(9):1062-72.
2000: Loeser R F
Aging and the etiopathogenesis and treatment of osteoarthritis.
Rheumatic diseases clinics of North America 2000;26(3):547-67.
2000: Loeser R F; Shanker G
Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro.
Arthritis and rheumatism 2000;43(7):1552-9.
2000: Loeser R F; Sadiev S; Tan L; Goldring M B
Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for alpha1beta1 and alpha2beta1 integrins in mediating chondrocyte adhesion to types II and VI collagen.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(2):96-105.
1999: Fernihough J K; Richmond R S; Carlson C S; Cherpes T; Holly J M; Loeser R F
Estrogen replacement therapy modulation of the insulin-like growth factor system in monkey knee joints.
Arthritis and rheumatism 1999;42(10):2103-11.
1998: Loeser R F
Evaluation of musculoskeletal complaints in the older adult.
Clinics in geriatric medicine 1998;14(3):401-15.
1997: Loeser R F; Varnum B C; Carlson C S; Goldring M B; Liu E T; Sadiev S; Kute T E; Wallin R
Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage.
Arthritis and rheumatism 1997;40(8):1455-65.
1997: Loeser R F
Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen.
Arthritis and rheumatism 1997;40(2):270-6.
1996: Carlson C S; Loeser R F; Purser C B; Gardin J F; Jerome C P
Osteoarthritis in cynomolgus macaques. III: Effects of age, gender, and subchondral bone thickness on the severity of disease.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(9):1209-17.
1995: Carlson C S; Loeser R F; Johnstone B; Tulli H M; Dobson D B; Caterson B
Osteoarthritis in cynomolgus macaques. II. Detection of modulated proteoglycan epitopes in cartilage and synovial fluid.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(3):399-409.
1995: Loeser R F; Carlson C S; McGee M P
Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage.
Experimental cell research 1995;217(2):248-57.
1994: Carlson C S; Loeser R F; Jayo M J; Weaver D S; Adams M R; Jerome C P
Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(3):331-9.
1994: Loeser R F
Modulation of integrin-mediated attachment of chondrocytes to extracellular matrix proteins by cations, retinoic acid, and transforming growth factor beta.
Experimental cell research 1994;211(1):17-23.
1993: Loeser R F
Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins.
Arthritis and rheumatism 1993;36(8):1103-10.
1993: Carlson C S; Tulli H M; Jayo M J; Loeser R F; Tracy R P; Mann K G; Adams M R
Immunolocalization of noncollagenous bone matrix proteins in lumbar vertebrae from intact and surgically menopausal cynomolgus monkeys.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(1):71-81.
1992: Loeser R F; Wallin R
Cell adhesion to matrix Gla protein and its inhibition by an Arg-Gly-Asp-containing peptide.
The Journal of biological chemistry 1992;267(14):9459-62.
1992: Loeser R; Carlson C S; Tulli H; Jerome W G; Miller L; Wallin R
Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization.
The Biochemical journal 1992;282 ( Pt 1)():1-6.
1992: Messier S P; Loeser R F; Hoover J L; Semble E L; Wise C M
Osteoarthritis of the knee: effects on gait, strength, and flexibility.
Archives of physical medicine and rehabilitation 1992;73(1):29-36.
1991: Loeser R F; Wallin R
Vitamin K-dependent carboxylation in articular chondrocytes.
Connective tissue research 1991;26(3):135-44.
1990: Semble E L; Loeser R F; Wise C M
Therapeutic exercise for rheumatoid arthritis and osteoarthritis.
Seminars in arthritis and rheumatism 1990;20(1):32-40.
1990: Dennison W B; Loeser R F; Turner R A; Johnson J A; Wells H B
A double blind placebo controlled trial of low dose clotrimazole in rheumatoid arthritis.
The Journal of rheumatology 1990;17(8):1003-7.
1990: Smith D M; Johnson J A; Loeser R; Turner R A
Evaluation of Tenidap (CP-66,248) on human neutrophil arachidonic acid metabolism, chemotactic potential and clinical efficacy in the treatment of rheumatoid arthritis.
Agents and actions 1990;31(1-2):102-9.
1990: Wallin R; Rossi F; Loeser R; Key L L
The vitamin K-dependent carboxylation system in human osteosarcoma U2-OS cells. Antidotal effect of vitamin K1 and a novel mechanism for the action of warfarin.
The Biochemical journal 1990;269(2):459-64.
1990: Loeser R F; Smith D M; Turner R A
Phospholipase activity in synovial fluid from patients with rheumatoid arthritis, osteoarthritis and crystal-associated arthritis.
Clinical and experimental rheumatology 1990;8(4):379-86.
1989: Hoppmann R A; Loeser R; Saluta G; Rothberger H
Anticardiolipin antibody: a marker of immune reactivity.
Clinical and experimental rheumatology 1989;7(3):283-6.
1988: Semble E L; Elster A D; Loeser R F; Laster D W; Challa V R; Pisko E J
Magnetic resonance imaging of the craniovertebral junction in rheumatoid arthritis.
The Journal of rheumatology 1988;15(9):1367-75.

Sign-in to see more