Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Hansruedi Loetscher

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice

Anatomy

Cell Line

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Physiology

Disorders

Alzheimer Disease

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
12
Brockhaus, Manfred
7
Jacobsen, Helmut
4
Ridley, RG
4
Haass, Christian
3
Bur, Daniel
3
Berry, Colin
3
D'Arcy, Allan
3
Kay, John
3
Lowry, Stephen
3
Metzger, Friedrich
3
Moldawer, Lyle
3
Moon, RP
3
Tyas, L
2
Welborn, Burress
2
van Loon, Adolphus

Sign-in to see all Coauthors

Publications

TOP 3
Brockhaus Manfred; Ganz Peter; Huber Walter; Bohrmann Bernd; Loetscher Hans-Ruedi; Seelig Joachim
Thermodynamic studies on the interaction of antibodies with beta-amyloid peptide.
Lopez-Lopez Cristina; Dietrich Marcelo O; Metzger Friedrich; Loetscher Hansruedi; Torres-Aleman Ignacio
Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.
Carro E; Trejo J L; Gerber A; Loetscher H; Torrado J; Metzger F; Torres-Aleman I
Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Hansruedi Loetscher (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2007: Brockhaus Manfred; Ganz Peter; Huber Walter; Bohrmann Bernd; Loetscher Hans-Ruedi; Seelig Joachim
Thermodynamic studies on the interaction of antibodies with beta-amyloid peptide.
The journal of physical chemistry. B 2007;111(5):1238-43.
2007: Lopez-Lopez Cristina; Dietrich Marcelo O; Metzger Friedrich; Loetscher Hansruedi; Torres-Aleman Ignacio
Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):824-31.
2006: Carro E; Trejo J L; Gerber A; Loetscher H; Torrado J; Metzger F; Torres-Aleman I
Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis.
Neurobiology of aging 2006;27(9):1250-7.
2005: Wellnitz Sabine; Friedlein Arno; Bonanni Corinne; Anquez Vivianne; Goepfert Fabienne; Loetscher Hansruedi; Adessi Celine; Czech Christian
A 13 kDa carboxy-terminal fragment of ApoE stabilizes Abeta hexamers.
Journal of neurochemistry 2005;94(5):1351-60.
2005: von Kienlin Markus; Künnecke Basil; Metzger Friedrich; Steiner Guido; Richards J Grayson; Ozmen Laurence; Jacobsen Helmut; Loetscher Hansruedi
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Neurobiology of disease 2005;18(1):32-9.
2003: Richards J Grayson; Higgins Guy A; Ouagazzal Abdel-Mouttalib; Ozmen Laurence; Kew James N C; Bohrmann Bernd; Malherbe Pari; Brockhaus Manfred; Loetscher Hansruedi; Czech Christian; Huber Gerda; Bluethmann Horst; Jacobsen Helmut; Kemp John A
PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8989-9003.
2002: Gill Ramanjit; Soriano Marc; Blomgren Klas; Hagberg Henrik; Wybrecht Remy; Miss Marie-Therese; Hoefer Sandra; Adam Geo; Niederhauser Olivier; Kemp John A; Loetscher Hansruedi
Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(4):420-30.
1999: Jacobsen H; Reinhardt D; Brockhaus M; Bur D; Kocyba C; Kurt H; Grim M G; Baumeister R; Loetscher H
The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.
The Journal of biological chemistry 1999;274(49):35233-9.
1999: Steiner H; Romig H; Pesold B; Philipp U; Baader M; Citron M; Loetscher H; Jacobsen H; Haass C
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
Biochemistry 1999;38(44):14600-5.
1999: Bernstein N K; Cherney M M; Loetscher H; Ridley R G; James M N
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nature structural biology 1999;6(1):32-7.
1998: Brockhaus M; Grünberg J; Röhrig S; Loetscher H; Wittenburg N; Baumeister R; Jacobsen H; Haass C
Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.
Neuroreport 1998;9(7):1481-6.
1998: Grunberg J; Walter J; Loetscher H; Deuschle U; Jacobsen H; Haass C
Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
Biochemistry 1998;37(8):2263-70.
1998: Tyas L; Moon R P; Loetscher H; Dunn B M; Kay J; Ridley R G; Berry C
Plasmepsins I and II from the malarial parasite Plasmodium falciparum.
Advances in experimental medicine and biology 1998;436():407-11.
1998: Moon R P; Bur D; Loetscher H; D'Arcy A; Tyas L; Oefner C; Grueninger-Leitch F; Mona D; Rupp K; Dorn A; Matile H; Certa U; Berry C; Kay J; Ridley R G
Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.
Advances in experimental medicine and biology 1998;436():397-406.
1997: Loetscher H; Deuschle U; Brockhaus M; Reinhardt D; Nelboeck P; Mous J; Grünberg J; Haass C; Jacobsen H
Presenilins are processed by caspase-type proteases.
The Journal of biological chemistry 1997;272(33):20655-9.
1997: Moon R P; Tyas L; Certa U; Rupp K; Bur D; Jacquet C; Matile H; Loetscher H; Grueninger-Leitch F; Kay J; Dunn B M; Berry C; Ridley R G
Expression and characterisation of plasmepsin I from Plasmodium falciparum.
European journal of biochemistry / FEBS 1997;244(2):552-60.
1996: van der Poll T; Jansen P M; Van Zee K J; Welborn M B; de Jong I; Hack C E; Loetscher H; Lesslauer W; Lowry S F; Moldawer L L
Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor.
Blood 1996;88(3):922-7.
1996: Welborn M B; Van Zee K; Edwards P D; Pruitt J H; Kaibara A; Vauthey J N; Rogy M; Castleman W L; Lowry S F; Kenney J S; Stüber D; Ettlin U; Wipf B; Loetscher H; Copeland E M; Lesslauer W; Moldawer L L
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon.
The Journal of experimental medicine 1996;184(1):165-71.
1996: Van Zee K J; Moldawer L L; Oldenburg H S; Thompson W A; Stackpole S A; Montegut W J; Rogy M A; Meschter C; Gallati H; Schiller C D; Richter W F; Loetscher H; Ashkenazi A; Chamow S M; Wurm F; Calvano S E; Lowry S F; Lesslauer W
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(6):2221-30.
1994: Evans T J; Moyes D; Carpenter A; Martin R; Loetscher H; Lesslauer W; Cohen J
Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis.
The Journal of experimental medicine 1994;180(6):2173-9.
1994: Mackay F; Rothe J; Bluethmann H; Loetscher H; Lesslauer W
Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-alpha activation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):5274-84.
1994: Rusten L S; Smeland E B; Jacobsen F W; Lien E; Lesslauer W; Loetscher H; Dubois C M; Jacobsen S E
Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors.
The Journal of clinical investigation 1994;94(1):165-72.
1994: Rusten L S; Jacobsen F W; Lesslauer W; Loetscher H; Smeland E B; Jacobsen S E
Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors.
Blood 1994;83(11):3152-9.
1994: Van Zee K J; Stackpole S A; Montegut W J; Rogy M A; Calvano S E; Hsu K C; Chao M; Meschter C L; Loetscher H; Stüber D
A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon.
The Journal of experimental medicine 1994;179(4):1185-91.
1993: Loetscher H; Stueber D; Banner D; Mackay F; Lesslauer W
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.
The Journal of biological chemistry 1993;268(35):26350-7.
1993: Banner D W; D'Arcy A; Janes W; Gentz R; Schoenfeld H J; Broger C; Loetscher H; Lesslauer W
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Cell 1993;73(3):431-45.
1993: Mackay F; Loetscher H; Stueber D; Gehr G; Lesslauer W
Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55.
The Journal of experimental medicine 1993;177(5):1277-86.
1993: D'Arcy A; Banner D W; Janes W; Winkler F K; Loetscher H; Schönfeld H J; Zulauf M; Gentz R; Lesslauer W
Crystallization and preliminary crystallographic analysis of a TNF-beta-55 kDa TNF receptor complex.
Journal of molecular biology 1993;229(2):555-7.
1993: Van Ostade X; Vandenabeele P; Everaerdt B; Loetscher H; Gentz R; Brockhaus M; Lesslauer W; Tavernier J; Brouckaert P; Fiers W
Human TNF mutants with selective activity on the p55 receptor.
Nature 1993;361(6409):266-9.
1992: Piguet P F; Grau G E; Vesin C; Loetscher H; Gentz R; Lesslauer W
Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.
Immunology 1992;77(4):510-4.
1992: Täuber M G; Sachdeva M; Kennedy S L; Loetscher H; Lesslauer W
Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis.
The Journal of infectious diseases 1992;166(5):1045-50.
1992: Vandenabeele P; Declercq W; Vercammen D; Van de Craen M; Grooten J; Loetscher H; Brockhaus M; Lesslauer W; Fiers W
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma.
The Journal of experimental medicine 1992;176(4):1015-24.
1992: Gehr G; Gentz R; Brockhaus M; Loetscher H; Lesslauer W
Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):911-7.
1992: Rothe J; Gehr G; Loetscher H; Lesslauer W
Tumor necrosis factor receptors--structure and function.
Immunologic research 1992;11(2):81-90.
1992: Loetscher H
Purification and structural properties of two distinct TNF receptors on human cells.
Immunology series 1992;56():161-87.
1991: Trefzer U; Brockhaus M; Loetscher H; Parlow F; Kapp A; Schöpf E; Krutmann J
55-kd tumor necrosis factor receptor is expressed by human keratinocytes and plays a pivotal role in regulation of human keratinocyte ICAM-1 expression.
The Journal of investigative dermatology 1991;97(5):911-6.
1991: Lesslauer W; Tabuchi H; Gentz R; Brockhaus M; Schlaeger E J; Grau G; Piguet P F; Pointaire P; Vassalli P; Loetscher H
Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality.
European journal of immunology 1991;21(11):2883-6.
1991: Loetscher H; Gentz R; Zulauf M; Lustig A; Tabuchi H; Schlaeger E J; Brockhaus M; Gallati H; Manneberg M; Lesslauer W
Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity.
The Journal of biological chemistry 1991;266(27):18324-9.
1991: Loetscher H; Steinmetz M; Lesslauer W
Tumor necrosis factor: receptors and inhibitors.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(6):221-6.
1991: Schoenfeld H J; Poeschl B; Frey J R; Loetscher H; Hunziker W; Lustig A; Zulauf M
Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors.
The Journal of biological chemistry 1991;266(6):3863-9.
1991: Loetscher H; Brockhaus M; Dembic Z; Gentz R; Gubler U; Hohmann H P; Lahm H W; Van Loon A P; Pan Y C; Schlaeger E J
Two distinct tumour necrosis factor receptors--members of a new cytokine receptor gene family.
Oxford surveys on eukaryotic genes 1991;7():119-42.
1990: Loetscher H; Schlaeger E J; Lahm H W; Pan Y C; Lesslauer W; Brockhaus M
Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells.
The Journal of biological chemistry 1990;265(33):20131-8.
1990: Shalaby M R; Sundan A; Loetscher H; Brockhaus M; Lesslauer W; Espevik T
Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors.
The Journal of experimental medicine 1990;172(5):1517-20.
1990: Dembic Z; Loetscher H; Gubler U; Pan Y C; Lahm H W; Gentz R; Brockhaus M; Lesslauer W
Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.
Cytokine 1990;2(4):231-7.
1990: Loetscher H; Pan Y C; Lahm H W; Gentz R; Brockhaus M; Tabuchi H; Lesslauer W
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor.
Cell 1990;61(2):351-9.
1990: Brockhaus M; Schoenfeld H J; Schlaeger E J; Hunziker W; Lesslauer W; Loetscher H
Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3127-31.
1990: Espevik T; Brockhaus M; Loetscher H; Nonstad U; Shalaby R
Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.
The Journal of experimental medicine 1990;171(2):415-26.
1989: Fountoulakis M; Kania M; Ozmen L; Loetscher H R; Garotta G; van Loon A P
Structure and membrane topology of the high-affinity receptor for human IFN-gamma: requirements for binding IFN-gamma. One single 90-kilodalton IFN-gamma receptor can lead to multiple cross-linked products and isolated proteins.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3266-76.

Sign-in to see more