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Bernd-Michael Löffler

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
20
Clozel, Martine
13
Breu, V
4
Ackermann, Grit
3
Aebi, Johannes
3
Dehmlow, Henrietta
3
Ehrenreich, Hannelore
3
Sirén, Anna-Leena
3
Hasselblatt, Martin
2
Park, Joon-Keun
2
Spiegel, Hans-Ullrich
2
Rodloff, Arne
2
Uhlmann, Dirk
2
Haller, Hermann
2
Fischli, Walter
2
Blum-Kaelin, Denise

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Publications

TOP 3
Gerber Michael; Walch Christiane; Löffler Birgit; Tischendorf Kristin; Reischl Udo; Ackermann Grit
Effect of sub-MIC concentrations of metronidazole, vancomycin, clindamycin and linezolid on toxin gene transcription and production in Clostridium difficile.
Schmidt Christoph; Löffler Birgit; Ackermann Grit
Antimicrobial phenotypes and molecular basis in clinical strains of Clostridium difficile.
Berger Yann; Dehmlow Henrietta; Blum-Kaelin Denise; Kitas Eric A; Löffler Bernd-Michael; Aebi Johannes D; Juillerat-Jeanneret Lucienne
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.

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All Publications

2008: Gerber Michael; Walch Christiane; Löffler Birgit; Tischendorf Kristin; Reischl Udo; Ackermann Grit
Effect of sub-MIC concentrations of metronidazole, vancomycin, clindamycin and linezolid on toxin gene transcription and production in Clostridium difficile.
Journal of medical microbiology 2008;57(Pt 6):776-83.
2007: Schmidt Christoph; Löffler Birgit; Ackermann Grit
Antimicrobial phenotypes and molecular basis in clinical strains of Clostridium difficile.
Diagnostic microbiology and infectious disease 2007;59(1):1-5.
2005: Berger Yann; Dehmlow Henrietta; Blum-Kaelin Denise; Kitas Eric A; Löffler Bernd-Michael; Aebi Johannes D; Juillerat-Jeanneret Lucienne
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
Journal of medicinal chemistry 2005;48(2):483-98.
2004: Ackermann G; Löffler B; Tang-Feldman Y J; Cohen S H; Silva J; Rodloff A C
Cloning and expression of Clostridium difficile toxin A gene (tcdA) by PCR amplification and use of an expression vector.
Molecular and cellular probes 2004;18(4):271-4.
2004: Ackermann Grit; Löffler Birgit; Adler Daniela; Rodloff Arne C
In vitro activity of OPT-80 against Clostridium difficile.
Antimicrobial agents and chemotherapy 2004;48(6):2280-2.
2002: Muller Dominik N; Mullally Alexander; Dechend Ralf; Park Joon-Keun; Fiebeler Anette; Pilz Bernhard; Löffler Bernd-Michael; Blum-Kaelin Denise; Masur Stefan; Dehmlow Henrietta; Aebi Johannes D; Haller Hermann; Luft Friedrich C
Endothelin-converting enzyme inhibition ameliorates angiotensin II-induced cardiac damage.
Hypertension 2002;40(6):840-6.
2002: Kitas Eric A; Löffler Bernd-Michael; Daetwyler Stefan; Dehmlow Henrietta; Aebi Johannes D
Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(13):1727-30.
2002: Wollensak Gregor; Löffler Bernd; Beyermann Beate; Ihling Christian
An immunohistochemical study of endothelin-1 converting enzyme in the human eye.
Current eye research 2002;24(1):6-11.
2001: Hasselblatt M; Lewczuk P; Löffler B M; Kamrowski-Kruck H; von Ahsen N; Sirén A L; Ehrenreich H
Role of the astrocytic ET(B) receptor in the regulation of extracellular endothelin-1 during hypoxia.
Glia 2001;34(1):18-26.
2001: Uhlmann D; Uhlmann S; Löffler B M; Witzigmann H; Spiegel H U
Pharmacological regulation of postischemic sinusoidal diameters in rats--a new approach for reducing hepatic ischemia/reperfusion injury.
Clinical hemorheology and microcirculation 2001;24(4):233-46.
2000: Muller D N; Mervaala E M; Schmidt F; Park J K; Dechend R; Genersch E; Breu V; Löffler B M; Ganten D; Schneider W; Haller H; Luft F C
Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage.
Hypertension 2000;36(2):282-90.
1999: Clozel M; Hess P; Fischli W; Löffler B M; Zwacka R M; Reuter A; Weiher H
Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease.
Experimental gerontology 1999;34(8):1007-15.
1999: Clozel M; Ramuz H; Clozel J P; Breu V; Hess P; Löffler B M; Coassolo P; Roux S
Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use.
The Journal of pharmacology and experimental therapeutics 1999;290(2):840-6.
1999: Ehrenreich H; Löffler B M; Hasselblatt M; Langen H; Oldenburg J; Subkowski T; Schilling L; Sirén A L
Endothelin converting enzyme activity in primary rat astrocytes is modulated by endothelin B receptors.
Biochemical and biophysical research communications 1999;261(1):149-55.
1999: Pieske B; Beyermann B; Breu V; Löffler B M; Schlotthauer K; Maier L S; Schmidt-Schweda S; Just H; Hasenfuss G
Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium.
Circulation 1999;99(14):1802-9.
1999: Scommotau S; Uhlmann D; Löffler B M; Breu V; Spiegel H U
Involvement of endothelin/nitric oxide balance in hepatic ischemia/reperfusion injury.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 1999;384(1):65-70.
1999: Ehrenreich H; Oldenburg J; Hasselblatt M; Herms J; Dembowski C; Löffler B M; Brück W; Kamrowski-Kruck H; Gall S; Sirén A L; Schilling L
Endothelin B receptor-deficient rats as a subtraction model to study the cerebral endothelin system.
Neuroscience 1999;91(3):1067-75.
1996: Karam H; Heudes D; Gonzales M F; Löffler B M; Clozel M; Clozel J P
Respective role of humoral factors and blood pressure in aortic remodeling of DOCA hypertensive rats.
American journal of hypertension 1996;9(10 Pt 1):991-8.
1996: Karam H; Heudes D; Bruneval P; Gonzales M F; Löffler B M; Clozel M; Clozel J P
Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism.
Hypertension 1996;28(3):379-85.
1996: Brändli P; Löffler B M; Breu V; Osterwalder R; Maire J P; Clozel M
Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater.
Pain 1996;64(2):315-22.
1996: Karam H; Heudes D; Hess P; Gonzales M F; Löffler B M; Clozel M; Clozel J P
Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats.
Cardiovascular research 1996;31(2):287-95.
1995: Roux S; Löffler B M; Gray G A; Sprecher U; Clozel M; Clozel J P
The role of endothelin in experimental cerebral vasospasm.
Neurosurgery 1995;37(1):78-85; discussion 85-6.
1995: Breu V; Hashido K; Broger C; Miyamoto C; Furuichi Y; Hayes A; Kalina B; Löffler B M; Ramuz H; Clozel M
Separable binding sites for the natural agonist endothelin-1 and the non-peptide antagonist bosentan on human endothelin-A receptors.
European journal of biochemistry / FEBS 1995;231(1):266-70.
1995: Karam H; Bruneval P; Clozel J P; Löffler B M; Bariéty J; Clozel M
Role of endothelin in acute renal failure due to rhabdomyolysis in rats.
The Journal of pharmacology and experimental therapeutics 1995;274(1):481-6.
1995: Teerlink J R; Carteaux J P; Sprecher U; Löffler B M; Clozel M; Clozel J P
Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs.
The American journal of physiology 1995;268(1 Pt 2):H432-40.
1994: Teerlink J R; Löffler B M; Hess P; Maire J P; Clozel M; Clozel J P
Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).
Circulation 1994;90(5):2510-8.
1994: Clozel M; Breu V; Gray G A; Kalina B; Löffler B M; Burri K; Cassal J M; Hirth G; Müller M; Neidhart W
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1994;270(1):228-35.
1994: Löffler B M; Mielenz E; Kunze H
Heterogeneity of Wistar rats with respect to acid beta-D-glucuronidase (EC 3.2.1.31) in liver.
Biochemistry and molecular biology international 1994;33(2):235-44.
1994: Gray G A; Löffler B M; Clozel M
Characterization of endothelin receptors mediating contraction of rabbit saphenous vein.
The American journal of physiology 1994;266(3 Pt 2):H959-66.
1993: Breu V; Löffler B M; Clozel M
In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors.
FEBS letters 1993;334(2):210-4.
1993: Clozel M; Breu V; Burri K; Cassal J M; Fischli W; Gray G A; Hirth G; Löffler B M; Müller M; Neidhart W
Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist.
Nature 1993;365(6448):759-61.
1993: Löffler B M; Breu V; Clozel M
Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma.
FEBS letters 1993;333(1-2):108-10.
1993: Clozel M; Löffler B M; Breu V; Hilfiger L; Maire J P; Butscha B
Downregulation of endothelin receptors by autocrine production of endothelin-1.
The American journal of physiology 1993;265(1 Pt 1):C188-92.
1993: Löffler B M; Roux S; Kalina B; Clozel M; Clozel J P
Influence of congestive heart failure on endothelin levels and receptors in rabbits.
Journal of molecular and cellular cardiology 1993;25(4):407-16.
1993: Clozel M; Breu V; Gray G A; Löffler B M
In vivo pharmacology of Ro 46-2005, the first synthetic nonpeptide endothelin receptor antagonist: implications for endothelin physiology.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S377-9.
1992: Löffler B M; Kunze H
Implication of acid cholesteryl ester hydrolase in the regulation of steroid biosynthesis in rat Leydig cells.
Biochemistry international 1992;28(6):965-74.
1992: Löffler B M; Jacot-Guillarmod H; Maire J P
Concentrations and ratios of immunoreactive big-endothelin-1 and endothelin-1 in human, rat and rabbit plasma.
Biochemistry international 1992;27(5):755-61.
1992: Kalina B; Löffler B M
Crosslinking analysis of an endothelin receptor protein from human placenta.
Biochemistry international 1992;27(4):735-44.
1992: Clozel M; Gray G A; Breu V; Löffler B M; Osterwalder R
The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo.
Biochemical and biophysical research communications 1992;186(2):867-73.
1992: Bohn E; Gerke V; Kresse H; Löffler B M; Kunze H
Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase.
FEBS letters 1992;296(3):237-40.
1992: Löffler B M; Jacot-Guillarmod H
A rabbit antiserum raised against the hexapeptide endothelin(16-21) shows different binding affinities for endothelin-1, -2 and -3.
Life sciences 1992;50(25):2001-9.
1991: Löffler B M; Kalina B; Kunze H
Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver.
Biochemical and biophysical research communications 1991;181(2):840-5.
1991: Kresse H; Löffler B M; Kunze H
Improved procedure for the purification of hepatic lipase from rat liver homogenate.
Biochemistry international 1991;23(5):885-93.
1990: Schmidt M; Löffler B M; Kunze H
Protease inhibitors reduce lysosomal acid phospholipase A1 activity in cultured rat hepatocytes.
Biochemistry international 1990;20(2):337-42.
1989: Löffler B M; Kunze H
Biospecific dye-binding and hydrophobic interaction chromatography as tools for high yield preparation of purified phospholipase A1 from rat liver.
Biochimica et biophysica acta 1989;1003(3):225-31.
1989: Löffler B M; Kunze H
Refinement of the Coomassie brilliant blue G assay for quantitative protein determination.
Analytical biochemistry 1989;177(1):100-2.
1989: Kunze H; Löffler B M
Acid phospholipase A1 in liver--a brief survey.
Klinische Wochenschrift 1989;67(3):126-30.
1989: Löffler B M; Kunze H
An improved purification procedure for rat liver lysosomal phospholipase A1.
Biochemistry international 1989;18(1):129-39.
1988: Löffler B M; Bohn E; Kunze H
Inhibition of liver lysosomal acid phospholipase A1 by blood serum proteins.
Biochemistry international 1988;17(5):965-71.
1988: Kunze H; Bohn E; Löffler B M
Inhibitors of liver lysosomal acid phospholipase A1.
European journal of biochemistry / FEBS 1988;177(3):591-5.
1988: Kunze H; Löffler B M; Schmidt M
Acid phospholipase A activities in rat hepatocytes.
FEBS letters 1988;236(2):388-90.
1987: Löffler B M; Schmidt M; Kunze H
Disintegration of isolated cells.
Analytical biochemistry 1987;163(2):440-5.
1987: Löffler B M; Bohn E; Hesse B; Kunze H
[The action of benzydamine on phospholipase activation]
Arzneimittel-Forschung 1987;37(5A):618-21.
1987: Löffler B M; Kunze H
Fractionation, biochemical characterization and lysosomal phospholipases of human liver.
FEBS letters 1987;216(1):51-6.
1986: Kunze H; Hesse B; Löffler B M
Diacylglycerol hydrolysis in rat liver lysosomes.
FEBS letters 1986;204(2):377-80.
1985: Löffler B M; Bohn E; Hesse B; Kunze H
Effects of antimalarial drugs on phospholipase A and lysophospholipase activities in plasma membrane, mitochondrial, microsomal and cytosolic subcellular fractions of rat liver.
Biochimica et biophysica acta 1985;835(3):448-55.
1984: Löffler B M; Hesse B; Kunze H
A combined assay of three lysosomal marker enzymes: acid phosphatase, beta-D-glucuronidase, and beta-N-acetyl-D-hexosaminidase.
Analytical biochemistry 1984;142(2):312-6.

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