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John Logan

Research Profile

Procedures

Living Beings

Chemicals & Drugs

Physiology

Anatomy

Endothelium, Vascular

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Publications

TOP 3
Guerard W Byrne; Paul G Stalboerger; Eduardo Davila; Carrie J Heppelmann; Mozammel H Gazi; Hugh C J McGregor; Peter T LaBreche; William R Davies; Vinay P Rao; Keiji Oi; Henry D Tazelaar; John S Logan; Christopher G A McGregor
Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.
Guerard W Byrne; William R Davies; Keiji Oi; Vinay P Rao; Sumeet S Teotia; Davide Ricci; Henry D Tazelaar; Randall C Walker; John S Logan; Christopher G A McGregor
Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival.
Jeffrey G Gaca; James Z Appel; Jeffrey G Lukes; Gonzalo V Gonzalez-Stawinski; Aaron Lesher; Daniel Palestrant; John S Logan; Stephanie D Love; Zoie E Holzknecht; Jeffrey L Platt; William Parker; R Duane Davis
Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction.

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All Publications

2008: Guerard W Byrne; Paul G Stalboerger; Eduardo Davila; Carrie J Heppelmann; Mozammel H Gazi; Hugh C J McGregor; Peter T LaBreche; William R Davies; Vinay P Rao; Keiji Oi; Henry D Tazelaar; John S Logan; Christopher G A McGregor
Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation.
Xenotransplantation 2008;15(4):268-76.
2006: Guerard W Byrne; William R Davies; Keiji Oi; Vinay P Rao; Sumeet S Teotia; Davide Ricci; Henry D Tazelaar; Randall C Walker; John S Logan; Christopher G A McGregor
Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival.
Transplantation 2006;82(12):1787-91.
2006: Jeffrey G Gaca; James Z Appel; Jeffrey G Lukes; Gonzalo V Gonzalez-Stawinski; Aaron Lesher; Daniel Palestrant; John S Logan; Stephanie D Love; Zoie E Holzknecht; Jeffrey L Platt; William Parker; R Duane Davis
Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction.
Transplantation 2006;81(12):1686-94.
2006: Eduardo Davila; Guerard W Byrne; Peter T LaBreche; Hugh C J McGregor; Allison K Schwab; William R Davies; Vinay P Rao; Keiji Oi; Henry D Tazelaar; John S Logan; Christopher G A McGregor
T-cell responses during pig-to-primate xenotransplantation.
Xenotransplantation 2006;13(1):31-40.
2005: Christopher G A McGregor; William R Davies; Keiji Oi; Sumeet S Teotia; Johannes M Schirmer; Jack M Risdahl; Henry D Tazelaar; Walter K Kremers; Randall C Walker; Guerard W Byrne; John S Logan
Cardiac xenotransplantation: recent preclinical progress with 3-month median survival.
The Journal of thoracic and cardiovascular surgery 2005;130(3):844-51.
2005: Guerard W Byrne; Johannes M Schirmer; David N Fass; Sumeet S Teotia; Walter K Kremers; Hui Xu; Bashoo Naziruddin; Henry D Tazelaar; John S Logan; Christopher G A McGregor
Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(5):1011-20.
2005: Sumeet S Teotia; Randall C Walker; Johannes M Schirmer; Henry D Tazelaar; Marian G Michaels; Jack M Risdahl; Guerard W Byrne; John S Logan; Christopher G A McGregor
Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survival.
Xenotransplantation 2005;12(2):127-33.
2004: Christopher G A McGregor; Sumeet S Teotia; Guerard W Byrne; Marian G Michaels; Jack M Risdahl; Johannes M Schirmer; Henry D Tazelaar; Randall C Walker; John S Logan
Cardiac xenotransplantation: progress toward the clinic.
Transplantation 2004;78(11):1569-75.
2004: Johannes M Schirmer; David N Fass; Guerard W Byrne; Henry D Tazelaar; John S Logan; Christopher G A McGregor
Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival.
Xenotransplantation 2004;11(5):436-43.
2003: Hui Xu; Ajay Sharma; Jeannine Okabe; Cunqi Cui; Liping Huang; Yuan Yuan Wei; Hua Wan; Ying Lei; John S Logan; Marlon F Levy; Guerard W Byrne
Serologic analysis of anti-porcine endogenous retroviruses immune responses in humans after ex vivo transgenic pig liver perfusion.
ASAIO journal (American Society for Artificial Internal Organs : 1992) 2003;49(4):407-16.
2003: Ajay Sharma; Bashoo Naziruddin; Cunqi Cui; Michael J Martin; Hui Xu; Hua Wan; Ying Lei; Caren Harrison; Jessie Yin; Jeannine Okabe; Christine Mathews; Aileen Stark; Connie S Adams; Jeffrey Houtz; Barry S Wiseman; Guerard W Byrne; John S Logan
Pig cells that lack the gene for alpha1-3 galactosyltransferase express low levels of the gal antigen.
Transplantation 2003;75(4):430-6.
2003: Hui Xu; Dengping Yin; Bashoo Naziruddin; Libing Chen; Aileen Stark; Yuanyuan Wei; Ying Lei; JiKun Shen; John S Logan; Guerard W Byrne; Anita S Chong
The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejection.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1531-9.
2003: Sujatha Karoor; Jeanette Molina; Cody R Buchmann; Clark Colton; John S Logan; Lee W Henderson
Immunoaffinity removal of xenoreactive antibodies using modified dialysis or microfiltration membranes.
Biotechnology and bioengineering 2003;81(2):134-48.
2003: Michael J Martin; Dengping Yin; Connie Adams; Jeffrey Houtz; Jikun Shen; Anita S Chong; Ajay Sharma; Guerard W Byrne; Barry S Wiseman; John S Logan
Skin graft survival in genetically identical cloned pigs.
Cloning and stem cells 2003;5(2):117-21.
2002: Lisa E Diamond; Guerard W Byrne; Alexander Schwarz; Thomas A Davis; David H Adams; John S Logan
Analysis of the control of the anti-gal immune response in a non-human primate by galactose alpha1-3 galactose trisaccharide-polyethylene glycol conjugate.
Transplantation 2002;73(11):1780-7.
2002: Gonzalo V Gonzalez-Stawinski; Casey W Daggett; Christine L Lau; Sujatha Karoor; Stephanie D Love; John S Logan; Jeffrey G Gaca; William Parker; R Duane Davis
Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation.
Journal of the American College of Surgeons 2002;194(6):765-73.
2002: Hui Xu; Ajay Sharma; Ying Lei; Jeannine Okabe; Hua Wan; Anita S Chong; John S Logan; Guerard W Byrne
Development and characterization of anti-Gal B cell receptor transgenic Gal-/- mice.
Transplantation 2002;73(10):1549-57.
2002: Guerard W Byrne; Alexander Schwarz; Joanna R Fesi; Patrick Birch; Anna Nepomich; Ivona Bakaj; Margaret A Velardo; Cong Jiang; Adriana Manzi; HOWARD DINTZIS; Lisa E Diamond; John S Logan
Evaluation of different alpha-Galactosyl glycoconjugates for use in xenotransplantation.
Bioconjugate chemistry 2002;13(3):571-81.
2002: Gregor Warnecke; Sandra R Severson; Mustafa M Ugurlu; Cemal B Taner; John S Logan; Lisa E Diamond; Virginia M Miller; Christopher G A McGregor
Endothelial function in pigs transgenic for human complement regulating factor.
Transplantation 2002;73(7):1060-7.
2002: Dengping Yin; Lianli Ma; Jikun Shen; Guerard W Byrne; John S Logan; Anita S Chong
CTLA-41g in combination with anti-CD40L prolongs xenograft survival and inhibits anti-gal ab production in GT-Ko mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(1):41-7.
2001: Hui Xu; Ajay Sharma; Lieping Chen; C Harrison; Y Wei; Anita S Chong; John S Logan; Guerard W Byrne; A Shama
The structure of anti-Gal immunoglobulin genes in naïve and stimulated Gal knockout mice.
Transplantation 2001;72(11):1817-25.
2001: Patrick G Dean; Ari J Cohen; H Dalla Valle; J P Grande; Lisa E Diamond; Guerard W Byrne; John S Logan; Christopher G A McGregor; Mark D Stegall
The effect of anti-alphaGal antibody removal with immunoabsorption and splenectomy on CD46 transgenic kidney xenograft survival.
Transplantation proceedings 2001;33(1-2):721-2.
2001: Lisa E Diamond; C M Quinn; M J Martin; J Lawson; Jeffrey L Platt; John S Logan
A human CD46 transgenic pig model system for the study of discordant xenotransplantation.
Transplantation 2001;71(1):132-42.
2000: Shu S Lin; M J Hanaway; Gonzalo V Gonzalez-Stawinski; Christine L Lau; William Parker; R Duane Davis; Guerard W Byrne; Lisa E Diamond; John S Logan; Jeffrey L Platt
The role of anti-Galalpha1-3Gal antibodies in acute vascular rejection and accommodation of xenografts.
Transplantation 2000;70(12):1667-74.
2000: Anita S Chong; LianLi Ma; Dengping Yin; JiKun Shen; L Blinder; X XiuLong; James W Williams; G Byrne; Lisa E Diamond; John S Logan
Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice.
Xenotransplantation 2000;7(4):275-83.
2000: John S Logan
Prospects for xenotransplantation.
Current opinion in immunology 2000;12(5):563-8.
2000: Christine L Lau; W C Daggett; MF Yeatman; PJ Chai; Shu S Lin; Andrew J Lodge; EP Chen; Lisa E Diamond; Guerard W Byrne; John S Logan; William Parker; Jeffrey L Platt; R Duane Davis
The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants.
The Journal of thoracic and cardiovascular surgery 2000;120(1):29-38.
2000: Jürgen Schneider-Schaulies; M J Martin; John S Logan; R Firsching; Volker ter Meulen; Lisa E Diamond
CD46 transgene expression in pig peripheral blood mononuclear cells does not alter their susceptibility to measles virus or their capacity to downregulate endogenous and transgenic CD46.
The Journal of general virology 2000;81(Pt 6):1431-8.
1999: R H Chen; S Naficy; John S Logan; Lisa E Diamond; David H Adams
Hearts from transgenic pigs constructed with CD59/DAF genomic clones demonstrate improved survival in primates.
Xenotransplantation 1999;6(3):194-200.
1999: MF Yeatman; Casey W Daggett; Christine L Lau; Guerard W Byrne; John S Logan; Jeffrey L Platt; R Duane Davis
Human complement regulatory proteins protect swine lungs from xenogeneic injury.
The Annals of thoracic surgery 1999;67(3):769-75.
1999: Masahide Tone; Lisa E Diamond; LA Walsh; Yukiko Tone; SA Thompson; E M Shanahan; John S Logan; Herman Waldmann
High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1.
The Journal of biological chemistry 1999;274(2):710-6.
1998: Merete Blixenkrone-Møller; A Bernard; A Bencsik; Nathalie Sixt; Lisa E Diamond; John S Logan; T Fabian Wild
Role of CD46 in measles virus infection in CD46 transgenic mice.
Virology 1998;249(2):238-48.
1998: MF Yeatman; Casey W Daggett; William Parker; Guerard W Byrne; John S Logan; Jeffrey L Platt; R Duane Davis
Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplant models.
Transplantation 1998;65(8):1084-93.
1998: Shu S Lin; B C Weidner; Guerard W Byrne; Lisa E Diamond; Jeffrey H Lawson; Charles W Hoopes; Larkin J Daniels; Casey W Daggett; William Parker; robert harland; R Duane Davis; R Randal Bollinger; John S Logan; Jeffrey L Platt
The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants.
The Journal of clinical investigation 1998;101(8):1745-56.
1998: D L Kooyman; Guerard W Byrne; John S Logan
Glycosyl phosphatidylinositol anchor.
Experimental nephrology 1998;6(2):148-51.
1997: K R McCurry; William Parker; A H Cotterell; B C Weidner; Shu S Lin; Larkin J Daniels; Zoie E Holzknecht; Guerard W Byrne; Lisa E Diamond; John S Logan; Jeffrey L Platt
Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.
Human immunology 1997;58(2):91-105.
1997: Stefan Niewiesk; Jürgen Schneider-Schaulies; H Ohnimus; Christian Jassoy; Sibylle Schneider-Schaulies; Lisa E Diamond; John S Logan; Volker ter Meulen
CD46 expression does not overcome the intracellular block of measles virus replication in transgenic rats.
Journal of virology 1997;71(10):7969-73.
1997: Shu S Lin; D L Kooyman; Larkin J Daniels; Casey W Daggett; William Parker; Jeffrey H Lawson; Charles W Hoopes; Carmelo Gullotto; L Li; P Birch; R Duane Davis; Lisa E Diamond; John S Logan; Jeffrey L Platt
The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants.
Transplant immunology 1997;5(3):212-8.
1997: Casey W Daggett; MF Yeatman; Andrew J Lodge; EP Chen; P Van Trigt; Guerard W Byrne; John S Logan; Jeffrey H Lawson; Jeffrey L Platt; R Duane Davis
Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model.
The Journal of thoracic and cardiovascular surgery 1997;113(2):390-8.
1997: Guerard W Byrne; K R McCurry; M J Martin; S M McClellan; Jeffrey L Platt; John S Logan
Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage.
Transplantation 1997;63(1):149-55.
1996: A Sharma; J Okabe; P Birch; S B McClellan; M J Martin; Jeffrey L Platt; John S Logan
Reduction in the level of Gal(alpha1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7190-5.
1996: Lisa E Diamond; K R McCurry; M J Martin; S B McClellan; E R Oldham; Jeffrey L Platt; John S Logan
Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium.
Transplantation 1996;61(8):1241-9.
1996: K R McCurry; Lisa E Diamond; D L Kooyman; Guerard W Byrne; M J Martin; John S Logan; Jeffrey L Platt
Human complement regulatory proteins expressed in transgenic swine protect swine xenografts from humoral injury.
Transplantation proceedings 1996;28(2):758.
1996: E R Oldham; M A Velardo; Jeffrey L Platt; John S Logan; L Diamond
High-level tissue specific expression of human CD59, MCP, and DAF proteins from genomic clones in transgenic mice.
Transplantation proceedings 1996;28(2):693.
1996: C G Alvarado; A H Cotterell; William Parker; John S Logan; Jeffrey L Platt
Variation in expression of biologically reactive xenoantigen does not correlate with expression of Gal alpha (1-3)Gal.
Transplantation proceedings 1996;28(2):555.
1996: D L Kooyman; S B McClellan; W R Parker; P L Avissar; M A Velardo; D H Nielsen; Jeffrey L Platt; John S Logan
Identification and characterization of a peptide mimeotope of galactose alpha 1,3 galactose.
Transplantation proceedings 1996;28(2):554.
1996: D L Kooyman; S B McClellan; William Parker; P L Avissar; M A Velardo; Jeffrey L Platt; John S Logan
Identification and characterization of a galactosyl peptide mimetic. Implications for use in removing xenoreactive anti-A Gal antibodies.
Transplantation 1996;61(6):851-5.
1995: Lisa E Diamond; K R McCurry; E R Oldham; Masahide Tone; Herman Waldmann; Jeffrey L Platt; John S Logan
Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement.
Transplant immunology 1995;3(4):305-12.
1995: Guerard W Byrne; K R McCurry; D Kagan; C Quinn; M J Martin; Jeffrey L Platt; John S Logan
Protection of xenogeneic cardiac endothelium from human complement by expression of CD59 or DAF in transgenic mice.
Transplantation 1995;60(10):1149-56.
1995: D L Kooyman; Guerard W Byrne; S McClellan; D Nielsen; Masahide Tone; Herman Waldmann; T M Coffman; K R McCurry; Jeffrey L Platt; John S Logan
In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.
Science (New York, N.Y.) 1995;269(5220):89-92.
1995: C G Alvarado; A H Cotterell; K R McCurry; B H Collins; John Magee; J Berthold; John S Logan; Jeffrey L Platt
Variation in the level of xenoantigen expression in porcine organs.
Transplantation 1995;59(11):1589-96.
1995: K R McCurry; D L Kooyman; C G Alvarado; A H Cotterell; M J Martin; John S Logan; Jeffrey L Platt
Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury.
Nature medicine 1995;1(5):423-7.
1995: K R McCurry; D L Kooyman; Lisa E Diamond; Guerard W Byrne; John S Logan; Jeffrey L Platt
Transgenic expression of human complement regulatory proteins in mice results in diminished complement deposition during organ xenoperfusion.
Transplantation 1995;59(8):1177-82.
1995: B H Collins; Ravi Chari; John Magee; robert harland; B J Lindman; John S Logan; R Randal Bollinger; William C Meyers; Jeffrey L Platt
Immunopathology of porcine livers perfused with blood of humans with fulminant hepatic failure.
Transplantation proceedings 1995;27(1):280-1.
1995: A H Cotterell; C G Alvarado; John S Logan; Jeffrey L Platt
Variation in expression of porcine antigens recognized by human xenoreactive natural antibodies.
Transplantation proceedings 1995;27(1):278-9.
1995: K R McCurry; D L Kooyman; Lisa E Diamond; Guerard W Byrne; M J Martin; John S Logan; Jeffrey L Platt
Human complement regulatory proteins in transgenic animals regulate complement activation in xenoperfused organs.
Transplantation proceedings 1995;27(1):317-8.
1994: B H Collins; Ravi Chari; John Magee; robert harland; B J Lindman; John S Logan; R Randal Bollinger; William C Meyers; Jeffrey L Platt
Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure.
Transplantation 1994;58(11):1162-71.
1994: robert harland; John S Logan; D Kooyman; Guerard W Byrne; Jeffrey L Platt
Ex vivo perfusion of mouse hearts expressing the human complement regulatory protein CD59.
Transplantation proceedings 1994;26(3):1245.
1994: Lisa E Diamond; E R Oldham; Jeffrey L Platt; Herman Waldmann; Masahide Tone; L A Walsh; John S Logan
Cell- and tissue-specific expression of a human CD59 minigene in transgenic mice.
Transplantation proceedings 1994;26(3):1239.