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Ton Logtenberg

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John de Kruif; Arjen Kramer; Roy Nijhuis; Vanessa van der Zande; Renate den Blanken; Carina Clements; Therèse Visser; Rob Keehnen; Marcel den Hartog; Mark Throsby; Ton Logtenberg
Generation of stable cell clones expressing mixtures of human antibodies.
John de Kruif; Arjen Kramer; Therèse Visser; Carina Clements; Roy Nijhuis; Freek Cox; Vanessa van der Zande; Renate Smit; Daniel Pinto; Mark Throsby; Ton Logtenberg
Human immunoglobulin repertoires against tetanus toxoid contain a large and diverse fraction of high-affinity promiscuous V(H) genes.
Ton Logtenberg
Antibody cocktails: next-generation biopharmaceuticals with improved potency.

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All Publications

2010: John de Kruif; Arjen Kramer; Roy Nijhuis; Vanessa van der Zande; Renate den Blanken; Carina Clements; Therèse Visser; Rob Keehnen; Marcel den Hartog; Mark Throsby; Ton Logtenberg
Generation of stable cell clones expressing mixtures of human antibodies.
Biotechnology and bioengineering 2010;106(5):741-50.
2009: John de Kruif; Arjen Kramer; Therèse Visser; Carina Clements; Roy Nijhuis; Freek Cox; Vanessa van der Zande; Renate Smit; Daniel Pinto; Mark Throsby; Ton Logtenberg
Human immunoglobulin repertoires against tetanus toxoid contain a large and diverse fraction of high-affinity promiscuous V(H) genes.
Journal of molecular biology 2009;387(3):548-58.
2007: Ton Logtenberg
Antibody cocktails: next-generation biopharmaceuticals with improved potency.
Trends in biotechnology 2007;25(9):390-4.
2004: Haiko J Bloemendal; Hetty C de Boer; Elianne A Koop; Alice J van Dongen; roel goldschmeding; Wil Landman; Ton Logtenberg; Martijn F B G Gebbink; Emile E Voest
Activated vitronectin as a target for anticancer therapy with human antibodies.
Cancer immunology, immunotherapy : CII 2004;53(9):799-808.
2004: Ya-Ping Wu; Haiko J Bloemendal; Emile E Voest; Ton Logtenberg; Philip G de Groot; Martijn F B G Gebbink; Hetty C de Boer
Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin.
Blood 2004;104(4):1034-41.
2003: Ildiko Van Rhijn; Ton Logtenberg; C Wim Ang; Leonard H Van den Berg
Gammadelta T cell non-responsiveness in Campylobacter jejuni-associated Guillain-Barré syndrome patients.
Neurology 2003;61(7):994-6.
2003: R Arjen Kramer; Freek Cox; Marieke van der Horst; Sonja van der Oudenrijn; Pieter C M Res; Judith Bia; Ton Logtenberg; John de Kruif
A novel helper phage that improves phage display selection efficiency by preventing the amplification of phages without recombinant protein.
Nucleic acids research 2003;31(11):e59.
2003: Ildiko Van Rhijn; Leonard H Van den Berg; C Wim Ang; Joke Admiraal; Ton Logtenberg
Expansion of human gammadelta T cells after in vitro stimulation with Campylobacter jejuni.
International immunology 2003;15(3):373-82.
2003: David Jones; Nathalie Kroos; Regina Anema; Bart van Montfort; Andre Vooys; Sven van der Kraats; Esmeralda van der Helm; Shirley Smits; Jan Schouten; Kirsten Brouwer; Fija Lagerwerf; Patrick van Berkel; Dirk-Jan Opstelten; Ton Logtenberg; Abraham Bout
High-level expression of recombinant IgG in the human cell line per.c6.
Biotechnology progress 2003;19(1):163-8.
2002: Menzo J E Havenga; Angelique A C Lemckert; Olga J A E Ophorst; Marja Van Meijer; Wilfred T V Germeraad; Jos M Grimbergen; M A van Den Doel; Ronald Vogels; Judith C T van Deutekom; A A M Janson; J D de Bruijn; Fons Uytdehaag; Paul H A Quax; Ton Logtenberg; M Mehtali; Abraham Bout
Exploiting the natural diversity in adenovirus tropism for therapy and prevention of disease.
Journal of virology 2002;76(9):4612-20.
2002: Yuk Yin Ng; Andries C Bloem; Berris van Kessel; Henk M Lokhorst; Ton Logtenberg; Frank Staal
Selective in vitro expansion and efficient retroviral transduction of human CD34+ CD38- haematopoietic stem cells.
British journal of haematology 2002;117(1):226-37.
2001: Gerwin Huls; D Gestel; J van der Linden; Ed E. Moret; Ton Logtenberg
Tumor cell killing by in vitro affinity-matured recombinant human monoclonal antibodies.
Cancer immunology, immunotherapy : CII 2001;50(3):163-71.
2001: W M J Bosboom; Leonard H Van den Berg; I Mollee; L D Sasker; J Jansen; J H J Wokke; Ton Logtenberg
Sural nerve T-cell receptor Vbeta gene utilization in chronic inflammatory demyelinating polyneuropathy and vasculitic neuropathy.
Neurology 2001;56(1):74-81.
2000: Ildiko Van Rhijn; Leonard H Van den Berg; W M J Bosboom; Henny G Otten; Ton Logtenberg
Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy.
Brain : a journal of neurology 2000;123 ( Pt 10)():2020-9.
2000: Leo Koenderman; Deon Kanters; B Maesen; Jan A M Raaijmakers; Jan-Willem J Lammers; John de Kruif; Ton Logtenberg
Monitoring of neutrophil priming in whole blood by antibodies isolated from a synthetic phage antibody library.
Journal of leukocyte biology 2000;68(1):58-64.
2000: Edwin Boel; S Verlaan; Miriam J J G Poppelier; N A Westerdaal; Jos van Strijp; Ton Logtenberg
Functional human monoclonal antibodies of all isotypes constructed from phage display library-derived single-chain Fv antibody fragments.
Journal of immunological methods 2000;239(1-2):153-66.
2000: John de Kruif; M Tijmensen; J Goldsein; Ton Logtenberg
Recombinant lipid-tagged antibody fragments as functional cell-surface receptors.
Nature medicine 2000;6(2):223-7.
2000: Hans-Christian Aasheim; Else Munthe; Steinar Funderud; Erlend Smeland; K Beiske; Ton Logtenberg
A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.
Blood 2000;95(1):221-30.
1999: AR van der Vuurst de Vries; Ton Logtenberg
A phage antibody identifying an 80-kDa membrane glycoprotein exclusively expressed on a subpopulation of activated B cells and hairy cell leukemia B cells.
European journal of immunology 1999;29(12):3898-907.
1999: Gerwin Huls; IA Heijnen; E Cuomo; J van der Linden; Edwin Boel; Jan G J van de Winkel; Ton Logtenberg
Antitumor immune effector mechanisms recruited by phage display-derived fully human IgG1 and IgA1 monoclonal antibodies.
Cancer research 1999;59(22):5778-84.
1999: J H Van Der Heijden; T W De Bruin; K A Glaudemans; John de Kruif; J P Banga; Ton Logtenberg
Limitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves' disease.
Clinical and experimental immunology 1999;118(2):205-12.
1999: AR van der Vuurst de Vries; Hans Clevers; Ton Logtenberg; Linde Meyaard
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling.
European journal of immunology 1999;29(10):3160-7.
1999: J Roose; Gerwin Huls; Moniek van Beest; Petra Moerer; Karin van der Horn; roel goldschmeding; Ton Logtenberg; Hans Clevers
Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Science (New York, N.Y.) 1999;285(5435):1923-6.
1999: W M J Bosboom; Leonard H Van den Berg; L De Boer; M J Van Son; H Veldman; Hessel Franssen; Ton Logtenberg; J H J Wokke
The diagnostic value of sural nerve T cells in chronic inflammatory demyelinating polyneuropathy.
Neurology 1999;53(4):837-45.
1999: AR van der Vuurst de Vries; Ton Logtenberg
Dissecting the human peripheral B-cell compartment with phage display-derived antibodies.
Immunology 1999;98(1):55-62.
1999: Haiko J Bloemendal; Ton Logtenberg; Emile E Voest
New strategies in anti-vascular cancer therapy.
European journal of clinical investigation 1999;29(9):802-9.
1999: Gerwin Huls; IA Heijnen; M E Cuomo; JC Koningsberger; L Wiegman; Edwin Boel; AR van der Vuurst de Vries; S A Loyson; Wijnand Helfrich; G P van Berge Henegouwen; Marja Van Meijer; John de Kruif; Ton Logtenberg
A recombinant, fully human monoclonal antibody with antitumor activity constructed from phage-displayed antibody fragments.
Nature biotechnology 1999;17(3):276-81.
1998: Hans-Christian Aasheim; Florence Pedeutour; Josiane Grosgeorge; Ton Logtenberg
Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2.
Biochemical and biophysical research communications 1998;252(2):378-82.
1998: Edwin Boel; HJ Bootsma; John de Kruif; M Jansze; K L Klingman; Hans van Dijk; Ton Logtenberg
Phage antibodies obtained by competitive selection on complement-resistant Moraxella (Branhamella) catarrhalis recognize the high-molecular-weight outer membrane protein.
Infection and immunity 1998;66(1):83-8.
1997: Hans-Christian Aasheim; L W Terstappen; Ton Logtenberg
Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis.
Blood 1997;90(9):3613-22.
1997: Jean van den Elsen; JN Herron; Peter Hoogerhout; Jan Poolman; Edwin Boel; Ton Logtenberg; J Wilting; Daan J A Crommelin; Jan Kroon; Piet Gros
Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.
Proteins 1997;29(1):113-25.
1997: JC Koningsberger; A Chott; Ton Logtenberg; L J Wiegman; R S Blumberg; Gerard P van Berge-Henegouwen; S P Balk
TCR expression in human fetal intestine and identification of an early T cell receptor beta-chain transcript.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1775-82.
1997: Willem van Ewijk; John de Kruif; Wilfred T V Germeraad; P Berendes; C Röpke; P P Platenburg; Ton Logtenberg
Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3903-8.
1997: Hans-Christian Aasheim; Ton Logtenberg; F Larsen
Subtractive hybridization for the isolation of differentially expressed genes using magnetic beads.
Methods in molecular biology (Clifton, N.J.) 1997;69():115-28.
1996: John de Kruif; Gert Storm; L van Bloois; Ton Logtenberg
Biosynthetically lipid-modified human scFv fragments from phage display libraries as targeting molecules for immunoliposomes.
FEBS letters 1996;399(3):232-6.
1996: John de Kruif; Ton Logtenberg
Leucine zipper dimerized bivalent and bispecific scFv antibodies from a semi-synthetic antibody phage display library.
The Journal of biological chemistry 1996;271(13):7630-4.
1995: N van der Stoep; S B Ebeling; Ton Logtenberg
Molecular analysis of VH regions expressed in the adult B-cell repertoire.
Annals of the New York Academy of Sciences 1995;764():275-84.
1995: John de Kruif; L Terstappen; Edwin Boel; Ton Logtenberg
Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3938-42.
1995: John de Kruif; Edwin Boel; Ton Logtenberg
Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions.
Journal of molecular biology 1995;248(1):97-105.
1994: R J Robijn; Ton Logtenberg; R H Houwen; Gerard P van Berge-Henegouwen; JC Koningsberger
[The intestines: an immune system within itself].
Nederlands tijdschrift voor geneeskunde 1994;138(47):2332-7.
1994: N van der Stoep; W Korver; Ton Logtenberg
In vivo and in vitro IgE isotype switching in human B lymphocytes: evidence for a predominantly direct IgM to IgE class switch program.
European journal of immunology 1994;24(6):1307-11.
1993: S B Ebeling; M E Schutte; Ton Logtenberg
Peripheral human CD5+ and CD5- B cells may express somatically mutated VH5- and VH6-encoded IgM receptors.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6891-9.
1993: M E Schutte; J H van Es; L E Silberstein; Ton Logtenberg
VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6569-76.
1993: S B Ebeling; M E Schutte; Ton Logtenberg
Molecular analysis of VH and VL regions expressed in IgG-bearing chronic lymphocytic leukemia (CLL): further evidence that CLL is a heterogeneous group of tumors.
Blood 1993;82(5):1626-31.
1993: R J Robijn; H Bloemendal; S Jainandunsing; L J Wiegman; Gerard P vanBerge-Henegouwen; Ton Logtenberg; JC Koningsberger
Phenotypic and molecular characterization of human monoclonal TCR gamma/delta T-cell lines from jejunum and colon of healthy individuals.
Scandinavian journal of immunology 1993;38(3):247-53.
1993: S B Ebeling; M E Schutte; Ton Logtenberg
The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.
European journal of immunology 1993;23(6):1405-8.
1993: N van der Stoep; J van der Linden; Ton Logtenberg
Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis.
The Journal of experimental medicine 1993;177(1):99-107.
1993: J H Van Es; F M Raaphorst; Maarten J D van Tol; F H Meyling; Ton Logtenberg
Expression pattern of the most JH-proximal human VH gene segment (VH6) in the B cell and antibody repertoire suggests a role of VH6-encoded IgM antibodies in early ontogeny.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):161-8.
1992: M E Schutte; S B Ebeling; K E Akkermans-Koolhaas; Ton Logtenberg
Deletion mapping of Ig VH gene segments expressed in human CD5 B cell lines. JH proximity is not the sole determinant of the restricted fetal VH gene repertoire.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):3953-60.
1992: J H van Es; F H Meyling; Ton Logtenberg
High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.
European journal of immunology 1992;22(10):2761-4.
1992: J H Van Es; H Aanstoot; Frits H J Gmelig-Meyling; R H Derksen; Ton Logtenberg
A human systemic lupus erythematosus-related anti-cardiolipin/single-stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51P1 VH gene.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2234-40.
1992: Ton Logtenberg; M E Schutte; S B Ebeling; Frits H J Gmelig-Meyling; J H van Es
Molecular approaches to the study of human B-cell and (auto)antibody repertoire generation and selection.
Immunological reviews 1992;128():23-47.
1992: J H van Es; M Heutink; H Aanstoot; Ton Logtenberg
Sequence analysis of members of the human Ig VH4 gene family derived from a single VH locus. Identification of novel germ-line members.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):492-7.
1992: S B Ebeling; M E Schutte; K E Akkermans-Koolhaas; Andries C Bloem; Frits H J Gmelig-Meyling; Ton Logtenberg
Expression of members of the immunoglobulin VH3 gene families is not restricted at the level of individual genes in human chronic lymphocytic leukemia.
International immunology 1992;4(3):313-20.
1991: M E Schutte; S B Ebeling; K E Akkermans; Frits H J Gmelig-Meyling; Ton Logtenberg
Antibody specificity and immunoglobulin VH gene utilization of human monoclonal CD5+ B cell lines.
European journal of immunology 1991;21(5):1115-21.
1991: Chris P M Broeren; Georges M G M Verjans; Willem van Eden; J G Kusters; J A Lenstra; Ton Logtenberg
Conserved nucleotide sequences at the 5' end of T cell receptor variable genes facilitate polymerase chain reaction amplification.
European journal of immunology 1991;21(3):569-75.
1991: J H van Es; Frits H J Gmelig-Meyling; W R van de Akker; H Aanstoot; R H Derksen; Ton Logtenberg
Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus.
The Journal of experimental medicine 1991;173(2):461-70.
1991: J H van Es; M E Schutte; S B Ebeling; Frits H J Gmelig-Meyling; Ton Logtenberg
Immunoglobulin variable gene expression in human autoantibodies.
Immunology series 1991;55():119-31.
1990: F Young; L Tucker; D Rubinstein; Thierry Guillaume; J André-Schwartz; K J Barrett; Robert S Schwartz; Ton Logtenberg
Molecular analysis of a germ line-encoded idiotypic marker of pathogenic human lupus autoantibodies.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2545-53.
1990: Thierry Guillaume; D B Rubinstein; F Young; L Tucker; Ton Logtenberg; Robert S Schwartz; K J Barrett
Individual VH genes detected with oligonucleotide probes from the complementarity-determining regions.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1934-45.
1990: Ton Logtenberg
Properties of polyreactive natural antibodies to self and foreign antigens.
Journal of clinical immunology 1990;10(3):137-40.
1989: Ton Logtenberg; F M Young; J H Van Es; Frits H J Gmelig-Meyling; F W Alt
Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.
The Journal of experimental medicine 1989;170(4):1347-55.
1989: Ton Logtenberg; F M Young; J van Es; Frits H J Gmelig-Meyling; J E Berman; F W Alt
Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies.
Journal of autoimmunity 1989;2 Suppl():203-13.
1989: Ton Logtenberg; M E Schutte; Giorgio Inghirami; J E Berman; Frits H J Gmelig-Meyling; R A Insel; Daniel M Knowles; F W Alt
Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.
International immunology 1989;1(4):362-6.
1988: Ton Logtenberg; P M Melissen; A Kroon; Frits H J Gmelig-Meyling; Rudy E Ballieux
Autoreactive B cells in normal humans. Autoantibody production upon lymphocyte stimulation with autoantigen-xenoantigen conjugates.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):446-50.
1987: Ton Logtenberg; A Kroon; Frits H J Gmelig-Meyling; R E Ballieux
Analysis of the human tonsil B cell repertoire by somatic hybridization: occurrence of both "monospecific" and "multispecific" (auto)antibody-secreting cells.
European journal of immunology 1987;17(6):855-9.
1986: Ton Logtenberg; A Kroon; Frits H J Gmelig-Meyling; R E Ballieux
Antigen-specific activation of autoreactive B cells in normal human individuals.
European journal of immunology 1986;16(12):1497-501.
1986: Ton Logtenberg; A Kroon; Frits H J Gmelig-Meyling; R E Ballieux
Production of anti-thyroglobulin antibody by blood lymphocytes from patients with autoimmune thyroiditis, induced by the insolubilized autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(4):1236-40.
1985: Ton Logtenberg; M Jonker; A Kroon; Frits H J Gmelig-Meyling; R E Ballieux
Enumeration of (auto)antibody producing cells in human using the "spot-ELISA".
Immunology letters 1985;9(6):343-7.