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Peng Loh

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Luca Crippa; Flavio Curnis; Elisabetta Ferrero; Anna Gasparri; Y Peng Loh; Mimma Bianco; Barbara Colombo; Angelo Corti
A new chromogranin A-dependent angiogenic switch activated by thrombin.
Hong Lou; Joshua J Park; Andre Phillips; Y Peng Loh
γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus.
Y Peng Loh; Angelo Corti
Commentary: granins, secretory granule biogenesis, and transport.

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2013: Luca Crippa; Flavio Curnis; Elisabetta Ferrero; Anna Gasparri; Y Peng Loh; Mimma Bianco; Barbara Colombo; Angelo Corti
A new chromogranin A-dependent angiogenic switch activated by thrombin.
Blood 2013;121(2):392-402.
2013: Hong Lou; Joshua J Park; Andre Phillips; Y Peng Loh
γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus.
Journal of molecular neuroscience : MN 2013;49(1):1-10.
2012: Y Peng Loh; Angelo Corti
Commentary: granins, secretory granule biogenesis, and transport.
Journal of molecular neuroscience : MN 2012;48(2):315-6.
2012: Y Peng Loh; Zhuan Zhou; Lung-Sen Kao
Proceedings of the 16th International Symposium on Chromaffin Cell Biology.
Journal of molecular neuroscience : MN 2012;48(2):313-4.
2012: Lung-Sen Kao; Y Peng Loh
Commentary: neurotransmitter secretion and cell signaling.
Journal of molecular neuroscience : MN 2012;48(2):427-8.
2012: Emilio Carbone; Nathalie C Guérineau; Y Peng Loh; Zhuan Zhou
Commentary: ion channels, fusion pores and exocytosis.
Journal of molecular neuroscience : MN 2012;48(2):357-9.
2012: Y Peng Loh; Sushil K Mahata; Yong Cheng; Angelo Corti; Bruno Tota
Chromogranin A and derived peptides in health and disease.
Journal of molecular neuroscience : MN 2012;48(2):347-56.
2012: Bruno Tota; Eleonora Bassino; Niamh X Cawley; Maria C Cerra; Stefano Gentile; Hisatsugu Koshimizu; Y Peng Loh; Teresa Pasqua; Tommaso Angelone
The novel chromogranin A-derived serpinin and pyroglutaminated serpinin peptides are positive cardiac β-adrenergic-like inotropes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(7):2888-98.
2012: Niamh X Cawley; Saravana R K Murthy; Karel Pacak; Joshua J Park; William C Wetsel; Y Peng Loh
New roles of carboxypeptidase E in endocrine and neural function and cancer.
Endocrine reviews 2012;33(2):216-53.
2012: Cheol Lee; Y Peng Loh; Yoh-suke Mukouyama; Sherry Ralls; Yanqin Yang; Jingqiong Hu; Toshio Kitamura; Sohyun Ahn
The molecular profiles of neural stem cell niche in the adult subventricular zone.
PloS one 2012;7(11):e50501.
2012: Marjorie C Gondré-Lewis; Joshua J Park; Y Peng Loh
Cellular mechanisms for the biogenesis and transport of synaptic and dense-core vesicles.
International review of cell and molecular biology 2012;299():27-115.
2011: Hisatsugu Koshimizu; Niamh X Cawley; Alfred L Yergy; Y Peng Loh
Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death.
Journal of molecular neuroscience : MN 2011;45(2):294-303.
2011: Hisatsugu Koshimizu; Niamh X Cawley; Taeyoon Kim; Alfred L Yergey; Y Peng Loh
Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells.
Molecular endocrinology (Baltimore, Md.) 2011;25(5):732-44.
2011: Joshua J Park; Marjorie C Gondré-Lewis; Lee E Eiden; Y Peng Loh
A distinct trans-Golgi network subcompartment for sorting of synaptic and granule proteins in neurons and neuroendocrine cells.
Journal of cell science 2011;124(Pt 5):735-44.
2011: Terence K Lee; Saravana R K Murthy; Niamh X Cawley; Savita Dhanvantari; Stephen M Hewitt; Hong Lou; Tracy Lau; Stephanie Ma; Thanh Huynh; Robert A Wesley; Irene O Ng; Karel Pacak; Ronnie T Poon; Y Peng Loh
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.
The Journal of clinical investigation 2011;121(3):880-92.
2011: Joshua J Park; Y Peng Loh
Visualization of peptide secretory vesicles in living nerve cells.
Methods in molecular biology (Clifton, N.J.) 2011;789():137-45.
2010: Hisatsugu Koshimizu; Taeyoon Kim; Niamh X Cawley; Y Peng Loh
Reprint of: Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis.
Regulatory peptides 2010;165(1):95-101.
2010: Saravana R K Murthy; Karel Pacak; Y Peng Loh
Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.
Cellular and molecular neurobiology 2010;30(8):1377-81.
2010: Antonis Voutetakis; Ana P Cotrim; Anne Rowzee; Changyu Zheng; Trushar Rathod; Tulin Yanik; Y Peng Loh; Bruce J Baum; Niamh X Cawley
Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland.
Endocrinology 2010;151(9):4566-72.
2010: Niamh X Cawley; Tulin Yanik; Alicja Woronowicz; Weizhong Chang; Joan C Marini; Y Peng Loh
Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density.
American journal of physiology. Endocrinology and metabolism 2010;299(2):E189-97.
2010: Hisatsugu Koshimizu; Taeyoon Kim; Niamh X Cawley; Y Peng Loh
Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis.
Regulatory peptides 2010;160(1-3):153-9.
2010: Alicja Woronowicz; Niamh X Cawley; Su-Youne Chang; Hisatsugu Koshimizu; Andrè W Phillips; Zhigang Xiong; Y Peng Loh
Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons.
Journal of neuroscience research 2010;88(1):64-72.
2009: Leona Plum; Hua Lin; Roxanne Dutia; Jun Tanaka; Kumiko S Aizawa; Michihiro Matsumoto; Andrea J Kim; Niamh X Cawley; Ji-Hye Paik; Y Peng Loh; Ronald A DePinho; Sharon L Wardlaw; Domenico Accili
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Nature medicine 2009;15(10):1195-201.
2009: Xiaodong Zhang; James Zhu; Y Peng Loh; Luc R Berghman
Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus.
Cell and tissue research 2009;337(3):371-9.
2009: Hisatsugu Koshimizu; Vladimir Senatorov; Y Peng Loh; Illana Gozes
Neuroprotective protein and carboxypeptidase E.
Journal of molecular neuroscience : MN 2009;39(1-2):1-8.
2008: Joshua J Park; Y Peng Loh
How peptide hormone vesicles are transported to the secretion site for exocytosis.
Molecular endocrinology (Baltimore, Md.) 2008;22(12):2583-95.
2008: Joshua J Park; Niamh X Cawley; Y Peng Loh
A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons.
Molecular and cellular neurosciences 2008;39(1):63-73.
2008: Yuval Samuni; Changyu Zheng; Niamh X Cawley; Ana P Cotrim; Y Peng Loh; Bruce J Baum
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands.
Biochemical and biophysical research communications 2008;373(1):136-9.
2008: Irina Arnaoutova; Niamh X Cawley; Nimesh Patel; Taeyoon Kim; Trushar Rathod; Y Peng Loh
Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells.
Molecular endocrinology (Baltimore, Md.) 2008;22(8):1924-34.
2008: Joshua J Park; Niamh X Cawley; Y Peng Loh
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones.
Molecular endocrinology (Baltimore, Md.) 2008;22(4):989-1005.
2008: Yuval Samuni; Niamh X Cawley; Changyu Zheng; Ana P Cotrim; Y Peng Loh; Bruce J Baum
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands.
Human gene therapy 2008;19(3):279-86.
2008: Alicja Woronowicz; Hisatsugu Koshimizu; Su-Youne Chang; Niamh X Cawley; Joanna M Hill; Ramona M Rodriguiz; Daniel Abebe; Caroline Dorfman; Vladimir Senatorov; An Zhou; Zhigang Xiong; William C Wetsel; Y Peng Loh
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.
Hippocampus 2008;18(10):1051-63.
2007: Hong Lou; Angela M Smith; Leigh C Coates; Niamh X Cawley; Y Peng Loh; Nigel P Birch
The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway.
Molecular and cellular endocrinology 2007;267(1-2):17-25.
2006: Marjorie C Gondré-Lewis; Horia I Petrache; Christopher A Wassif; Daniel Harries; Adrian Parsegian; Forbes D Porter; Y Peng Loh
Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature.
Journal of cell science 2006;119(Pt 9):1876-85.
2006: Taeyoon Kim; Marjorie C Gondré-Lewis; Irina Arnaoutova; Y Peng Loh
Dense-core secretory granule biogenesis.
Physiology (Bethesda, Md.) 2006;21():124-33.
2006: Taeyoon Kim; Y Peng Loh
Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation.
Molecular biology of the cell 2006;17(2):789-98.
2006: Tulin Yanik; Geraldina Dominguez; Michael J Kuhar; Emanuele M Del Giudice; Y Peng Loh
The Leu34Phe ProCART mutation leads to cocaine- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans.
Endocrinology 2006;147(1):39-43.
2005: Xuemei Zhu; Kebin Wu; Lawrence Rife; Niamh X Cawley; Bruce Brown; Tiffany Adams; Karen Teofilo; Concepcion Lillo; David S Williams; Y Peng Loh; Cheryl M Craft
Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina.
Journal of neurochemistry 2005;95(5):1351-62.
2005: Taeyoon Kim; Chun-fa Zhang; Ziqing Sun; Heling Wu; Y Peng Loh
Chromogranin A deficiency in transgenic mice leads to aberrant chromaffin granule biogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(30):6958-61.
2005: Taeyoon Kim; Y Peng Loh
Chromogranin A: a surprising link between granule biogenesis and hypertension.
The Journal of clinical investigation 2005;115(7):1711-3.
2005: Jianghua Wang; Niamh X Cawley; Antonis Voutetakis; Yazmin M Rodriguez; Corinne M Goldsmith; Lynnette K Nieman; A T M Shamsul Hoque; Stuart J Frank; Chris R Snell; Y Peng Loh; Bruce J Baum
Partial redirection of transgenic human growth hormone secretion from rat salivary glands.
Human gene therapy 2005;16(5):571-83.
2005: Hong Lou; Soo-Kyung Kim; Eugene Zaitsev; Chris R Snell; Bai Lu; Y Peng Loh
Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e.
Neuron 2005;45(2):245-55.
2004: Darren J Michael; Xuehui Geng; Niamh X Cawley; Y Peng Loh; Christopher J Rhodes; Peter Drain; Robert H Chow
Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
Biophysical journal 2004;87(6):L03-5.
2004: Niamh X Cawley; Jiechun Zhou; Joanna M Hill; Daniel Abebe; Sylvie Romboz; Tulin Yanik; Ramona M Rodriguiz; William C Wetsel; Y Peng Loh
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.
Endocrinology 2004;145(12):5807-19.
2004: Masoumeh Assadi; Juanita C Sharpe; Chris R Snell; Y Peng Loh
The C-terminus of prohormone convertase 2 is sufficient and necessary for Raft association and sorting to the regulated secretory pathway.
Biochemistry 2004;43(24):7798-807.
2004: Antonis Voutetakis; Marc R Kok; Changyu Zheng; Ioannis Bossis; Jianghua Wang; Ana P Cotrim; Natanya Marracino; Corinne M Goldsmith; John A Chiorini; Y Peng Loh; Lynnette K Nieman; Bruce J Baum
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3053-8.
2004: Y Peng Loh; Taeyoon Kim; Yazmin M Rodriguez; Niamh X Cawley
Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells.
Journal of molecular neuroscience : MN 2004;22(1-2):63-71.
2003: Irina Arnaoutova; Catherine L Jackson; Omayma S Al-Awar; Julie G Donaldson; Y Peng Loh
Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6.
Molecular biology of the cell 2003;14(11):4448-57.
2003: Irina Arnaoutova; Angela M Smith; Leigh C Coates; Juanita C Sharpe; Savita Dhanvantari; Chris R Snell; Nigel P Birch; Y Peng Loh
The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein.
Biochemistry 2003;42(35):10445-55.
2003: Savita Dhanvantari; Fu-Sheng Shen; Tiffany Adams; Chris R Snell; ChunFa Zhang; Robert B Mackin; Stephen J Morris; Y Peng Loh
Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia.
Molecular endocrinology (Baltimore, Md.) 2003;17(9):1856-67.
2003: Niamh X Cawley; Masao Chino; Alex Maldonado; Yazmin M Rodriguez; Y Peng Loh; Jonathan A Ellman
Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes.
The Journal of biological chemistry 2003;278(8):5523-30.
2003: Chun-fa Zhang; Savita Dhanvantari; Hong Lou; Y Peng Loh
Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts.
The Biochemical journal 2003;369(Pt 3):453-60.
2003: Mitsunori Fukuda; Eiko Kanno; Yukie Ogata; Chika Saegusa; Taeyoon Kim; Y Peng Loh; Akitsugu Yamamoto
Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells.
The Journal of biological chemistry 2003;278(5):3220-6.
2003: Niamh X Cawley; Yazmin M Rodriguez; Alex Maldonado; Y Peng Loh
Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.
Endocrinology 2003;144(1):292-8.
2002: Y Peng Loh; Alex Maldonado; Chunfa Zhang; Winnie H Tam; Niamh X Cawley
Mechanism of sorting proopiomelanocortin and proenkephalin to the regulated secretory pathway of neuroendocrine cells.
Annals of the New York Academy of Sciences 2002;971():416-25.
2002: Taeyoon Kim; Jung-Hwa Tao-Cheng; Lee E Eiden; Y Peng Loh
Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells.
Annals of the New York Academy of Sciences 2002;971():323-31.
2002: Savita Dhanvantari; Irina Arnaoutova; Chris R Snell; Peter J Steinbach; Kelli Hammond; Gregory A Caputo; Erwin London; Y Peng Loh
Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion.
Biochemistry 2002;41(1):52-60.
2001: Taeyoon Kim; Jung-Hwa Tao-Cheng; Lee E Eiden; Y Peng Loh
Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis.
Cell 2001;106(4):499-509.
2000: Savita Dhanvantari; Y Peng Loh
Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor.
The Journal of biological chemistry 2000;275(38):29887-93.
2000: Niamh X Cawley; E Normant; A Chen; Y Peng Loh
Oligomerization of pro-opiomelanocortin is independent of pH, calcium and the sorting signal for the regulated secretory pathway.
FEBS letters 2000;481(1):37-41.
2000: V Olsen; Y Peng Loh
In vivo processing of nonanchored Yapsin 1 (Yap3p).
Archives of biochemistry and biophysics 2000;375(2):315-21.
1999: Fu-Sheng Shen; Greti Aguilera; Y Peng Loh
Altered biosynthesis and secretion of pro-opiomelanocortin in the intermediate and anterior pituitary of carboxypeptidase E-deficient, Cpe(fat)/ Cpe(fat)mice.
Neuropeptides 1999;33(4):276-80.
1999: V Olsen; Niamh X Cawley; J Brandt; M Egel-Mitani; Y Peng Loh
Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene.
The Biochemical journal 1999;339 ( Pt 2)():407-11.
1999: Chun-fa Zhang; Chris R Snell; Y Peng Loh
Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor.
Molecular endocrinology (Baltimore, Md.) 1999;13(4):527-36.
1998: D R Cool; Y Peng Loh
Carboxypeptidase E is a sorting receptor for prohormones: binding and kinetic studies.
Molecular and cellular endocrinology 1998;139(1-2):7-13.
1998: E Normant; Y Peng Loh
Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.
Endocrinology 1998;139(4):2137-45.
1998: V Olsen; K Guruprasad; Niamh X Cawley; Hao-Chia Chen; T L Blundell; Y Peng Loh
Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling.
Biochemistry 1998;37(9):2768-77.
1998: Niamh X Cawley; V Olsen; Chun-fa Zhang; Hao-Chia Chen; M Tan; Y Peng Loh
Activation and processing of non-anchored yapsin 1 (Yap3p).
The Journal of biological chemistry 1998;273(1):584-91.
1998: V Olsen; Niamh X Cawley; Y Peng Loh
Yapsin1. Structure, biosynthesis, and specificity.
Advances in experimental medicine and biology 1998;436():315-9.
1997: Fu-Sheng Shen; Y Peng Loh
Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5314-9.
1997: Y Peng Loh; Chris R Snell; D R Cool
Receptor-mediated targeting of hormones to secretory granules: role of carboxypeptidase E.
Trends in endocrinology and metabolism: TEM 1997;8(4):130-7.
1997: P Lecchi; Y Peng Loh; Chris R Snell; Lewis K Pannell
The structure of synenkephalin (pro-enkephalin 1-73) is dictated by three disulfide bridges.
Biochemical and biophysical research communications 1997;232(3):800-5.
1997: D R Cool; E Normant; F Shen; H C Chen; Lewis K Pannell; Y Zhang; Y Peng Loh
Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice.
Cell 1997;88(1):73-83.
1996: D R Cool; D Y Louie; Y Peng Loh
Yeast aspartic protease 3 is sorted to secretory granules and activated to process proopiomelanocortin in PC12 cells.
Endocrinology 1996;137(12):5441-6.
1996: Niamh X Cawley; L P Pu; Y Peng Loh
Immunological identification and localization of yeast aspartic protease 3-like prohormone-processing enzymes in mammalian brain and pituitary.
Endocrinology 1996;137(11):5135-43.
1996: Jack A Yanovski; Susan Z Yanovski; T C Friedman; Y Peng Loh; V Jayasvasti; Gordon B Cutler; George Chrousos
Etiology of the differences in corticotropin-releasing hormone-induced adrenocorticotropin secretion of black and white women.
The Journal of clinical endocrinology and metabolism 1996;81(9):3307-11.
1996: L P Pu; W Ma; J L Barker; Y Peng Loh
Differential coexpression of genes encoding prothyrotropin-releasing hormone (pro-TRH) and prohormone convertases (PC1 and PC2) in rat brain neurons: implications for differential processing of pro-TRH.
Endocrinology 1996;137(4):1233-41.
1996: Niamh X Cawley; Hao-Chia Chen; M C Beinfeld; Y Peng Loh
Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3.
The Journal of biological chemistry 1996;271(8):4168-76.
1996: T C Friedman; D R Cool; V Jayasvasti; D Louie; Y Peng Loh
Processing of pro-opiomelanocortin in GH3 cells: inhibition by prohormone convertase 2 (PC2) antisense mRNA.
Molecular and cellular endocrinology 1996;116(1):89-96.
1995: E A Nillni; T C Friedman; R B Todd; Nigel P Birch; Y Peng Loh; IM Jackson
Pro-thyrotropin-releasing hormone processing by recombinant PC1.
Journal of neurochemistry 1995;65(6):2462-72.
1995: L P Pu; Fijs W B van Leeuwen; H L Tracer; M A F Sonnemans; Y Peng Loh
Localization of vasopressin mRNA and immunoreactivity in pituicytes of pituitary stalk-transected rats after osmotic stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10653-7.
1995: T C Friedman; Y Peng Loh; Niamh X Cawley; Nigel P Birch; S S Huang; IM Jackson; E A Nillni
Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes.
Endocrinology 1995;136(10):4462-72.
1995: Ana-Maria Bamberger; L P Pu; D R Cool; Y Peng Loh
The Neuro-2a neuroblastoma cell line expresses [Met]-enkephalin and vasopressin mRNA and peptide.
Molecular and cellular endocrinology 1995;113(2):155-63.
1995: Ana-Maria Bamberger; Christoph M Bamberger; L P Pu; L A Puy; Y Peng Loh; Sylvia Asa
Expression of pit-1 messenger ribonucleic acid and protein in the human placenta.
The Journal of clinical endocrinology and metabolism 1995;80(7):2021-6.
1995: Niamh X Cawley; M Wong; L P Pu; W Tam; Y Peng Loh
Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: characterization of secreted YAP3p.
Biochemistry 1995;34(22):7430-7.
1995: D R Cool; Mogens Fenger; C R Snell; Y Peng Loh
Identification of the sorting signal motif within pro-opiomelanocortin for the regulated secretory pathway.
The Journal of biological chemistry 1995;270(15):8723-9.
1995: L P Pu; W P Hayes; J F Mill; S Ghose; T C Friedman; Y Peng Loh
Frog prohormone convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing hormone-expressing neurons.
The Journal of comparative neurology 1995;354(1):71-86.
1995: T C Friedman; V M Gordon; Stephen H Leppla; KR Klimpel; Nigel P Birch; Y Peng Loh
In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes.
Archives of biochemistry and biophysics 1995;316(1):5-13.
1995: A V Azaryan; T C Friedman; Niamh X Cawley; Y Peng Loh
Characteristics of YAP3, a new prohormone processing aspartic protease from S. cerevisiae.
Advances in experimental medicine and biology 1995;362():569-72.
1995: Y Peng Loh; Niamh X Cawley; T C Friedman; L P Pu
Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion.
Advances in experimental medicine and biology 1995;362():519-27.
1995: Y Peng Loh; Niamh X Cawley
Processing enzymes of pepsin family: yeast aspartic protease 3 and pro-opiomelanocortin converting enzyme.
Methods in enzymology 1995;248():136-46.
1994: T C Friedman; Y Peng Loh; Nigel P Birch
In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3).
Endocrinology 1994;135(3):854-62.
1994: T C Friedman; D Garcia-Borreguero; D Hardwick; C N Akuete; M K Stambuk; Lorah D Dorn; monica starkman; Y Peng Loh; George Chrousos
Diurnal rhythm of plasma delta-sleep-inducing peptide in humans: evidence for positive correlation with body temperature and negative correlation with rapid eye movement and slow wave sleep.
The Journal of clinical endocrinology and metabolism 1994;78(5):1085-9.
1994: R A Rius; S Mollner; T Pfeuffer; Y Peng Loh
Developmental changes in Gs and G(olf) proteins and adenylyl cyclases in mouse brain membranes.
Brain research 1994;643(1-2):50-8.
1994: D R Cool; Y Peng Loh
Identification of a sorting signal for the regulated secretory pathway at the N-terminus of pro-opiomelanocortin.
Biochimie 1994;76(3-4):265-70.
1993: T C Friedman; Hao-Chia Chen; Y Peng Loh
Generation of 1-37 and 1-38 forms of adrenocorticotropin by mono- and dipeptidyl serine carboxypeptidase activities in bovine pituitary secretory vesicles.
Endocrinology 1993;133(6):2951-61.
1993: W W Tam; Katrin Andreasson; Y Peng Loh
The amino-terminal sequence of pro-opiomelanocortin directs intracellular targeting to the regulated secretory pathway.
European journal of cell biology 1993;62(2):294-306.
1993: Niamh X Cawley; B D Noe; Y Peng Loh
Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28.
FEBS letters 1993;332(3):273-6.
1993: H L Tracer; Y Peng Loh
The effect of salt-loading on corticotropin releasing hormone and arginine vasopressin mRNA levels in the mouse hypothalamus: a quantitative in situ hybridization analysis.
Neuropeptides 1993;25(3):161-7.
1993: A V Azaryan; M Wong; T C Friedman; Niamh X Cawley; F E Estivariz; Hao-Chia Chen; Y Peng Loh
Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme.
The Journal of biological chemistry 1993;268(16):11968-75.
1992: Y Peng Loh
Molecular mechanisms of beta-endorphin biosynthesis.
Biochemical pharmacology 1992;44(5):843-9.
1992: H L Tracer; Y Peng Loh; Nigel P Birch
Rat mitochondrial coupling factor 6: molecular cloning of a cDNA encoding the imported precursor.
Gene 1992;116(2):291-2.
1992: F E Estivariz; T C Friedman; T Chikuma; Y Peng Loh
Processing of adrenocorticotropin by two proteases in bovine intermediate lobe secretory vesicle membranes. A distinct acidic, tetrabasic residue-specific calcium-activated serine protease and a PC2-like enzyme.
The Journal of biological chemistry 1992;267(11):7456-63.
1992: Jacob Barg; R A Rius; W T Bem; Mariana M Belcheva; Y Peng Loh; Carmine J Coscia
Differential development of beta-endorphin and mu opioid binding sites in mouse brain.
Brain research. Developmental brain research 1992;66(1):71-6.
1991: Y Peng Loh; Katrin Andreasson; Nigel P Birch
Intracellular trafficking and processing of pro-opiomelanocortin.
Cell biophysics 1991;19(1-3):73-83.
1991: M Wong; R A Rius; Y Peng Loh
Characterization of Xenopus laevis proenkephalin gene.
Brain research. Molecular brain research 1991;11(3-4):197-205.
1991: Nigel P Birch; H P Bennett; F E Estivariz; Y Peng Loh
Effect of calcium ions on the processing of pro-opiomelanocortin by bovine intermediate lobe pro-opiomelanocortin-converting enzyme.
European journal of biochemistry / FEBS 1991;201(1):85-9.
1991: Nigel P Birch; H L Tracer; D J Hakes; Y Peng Loh
Coordinate regulation of mRNA levels of pro-opiomelanocortin and the candidate processing enzymes PC2 and PC3, but not furin, in rat pituitary intermediate lobe.
Biochemical and biophysical research communications 1991;179(3):1311-9.
1991: Nigel P Birch; F E Estivariz; H P Bennett; Y Peng Loh
Differential glycosylation of N-POMC1-77 regulates the production of gamma 3-MSH by purified pro-opiomelanocortin converting enzyme. A possible mechanism for tissue-specific processing.
FEBS letters 1991;290(1-2):191-4.
1991: Nigel P Birch; Y Peng Loh
Homology cloning of aspartic proteases from an endocrine cell line using the polymerase chain reaction.
Biochemical and biophysical research communications 1991;177(3):920-6.
1991: R A Rius; T Chikuma; Y Peng Loh
Prenatal processing of pro-opiomelanocortin in the brain and pituitary of mouse embryos.
Brain research. Developmental brain research 1991;60(2):179-85.
1991: R A Rius; Jacob Barg; W T Bem; Carmine J Coscia; Y Peng Loh
The prenatal development profile of expression of opioid peptides and receptors in the mouse brain.
Brain research. Developmental brain research 1991;58(2):237-41.
1991: Y Peng Loh; R A Rius; S Elkabes; W Bem; Carmine J Coscia
Prenatal expression of pro-opiomelanocortin mRNA, POMC-derived peptides, and mu-opiate receptors in the mouse embryo.
NIDA research monograph 1991;111():96-112.
1990: W P Hayes; Y Peng Loh
Correlated onset and patterning of proopiomelanocortin gene expression in embryonic Xenopus brain and pituitary.
Development (Cambridge, England) 1990;110(3):747-57.
1990: A Bjartell; R Ekman; Y Peng Loh
Biosynthesis and processing of delta sleep-inducing peptide-like precursors in primary cultures of mouse anterior pituitary cells.
European journal of biochemistry / FEBS 1990;190(1):131-7.
1989: F E Estivariz; Nigel P Birch; Y Peng Loh
Generation of Lys-gamma 3-melanotropin from pro-opiomelanocortin 1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme.
The Journal of biological chemistry 1989;264(30):17796-801.
1989: M G Castro; F Gusovsky; Y Peng Loh
Transmembrane signals mediating adrenocorticotropin release from mouse anterior pituitary cells.
Molecular and cellular endocrinology 1989;65(1-2):165-73.
1989: Katrin Andreasson; W W Tam; T O Feurst; Bernard Moss; Y Peng Loh
Production of pro-opiomelanocortin (POMC) by a vaccinia virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme.
FEBS letters 1989;248(1-2):43-7.
1989: M G Castro; Nigel P Birch; Y Peng Loh
Regulated secretion of pro-opiomelanocortin converting enzyme and an aminopeptidase B-like enzyme from dispersed bovine intermediate lobe pituitary cells.
Journal of neurochemistry 1989;52(5):1619-28.
1989: S Elkabes; Y Peng Loh; A Nieburgs; Susan Wray
Prenatal ontogenesis of pro-opiomelanocortin in the mouse central nervous system and pituitary gland: an in situ hybridization and immunocytochemical study.
Brain research. Developmental brain research 1989;46(1):85-95.
1988: S Elkabes; Y Peng Loh
Effect of salt loading on proopiomelanocortin (POMC) messenger ribonucleic acid levels, POMC biosynthesis, and secretion of POMC products in the mouse pituitary gland.
Endocrinology 1988;123(4):1754-60.
1988: Y Peng Loh
The effect of pepstatin A, an inhibitor of the pro-opiomelanocortin (POMC)-converting enzyme, on POMC processing in mouse intermediate pituitary.
FEBS letters 1988;238(1):142-6.
1988: Y Peng Loh; M G Castro; F J Zeng; U Patel-Vaidya
Presence of pro-vasopressin mRNA, neurophysin and arginine vasopressin in mouse anterior pituitary cells and the AtT-20 corticotrophic tumour cell line.
Journal of molecular endocrinology 1988;1(1):39-48.
1988: Y Peng Loh; Nigel P Birch; M G Castro
Pro-opiomelanocortin and pro-vasopressin converting enzyme in pituitary secretory vesicles.
Biochimie 1988;70(1):11-6.