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Martin Lohse

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Physiology

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Catharina Ruppert; Marie Vidal; Frank Weidemann; Mehmet Oezkur; Katharina Deiss; Armin Gorski; Sebastian Herrmann; Martin J Lohse; Kristina Lorenz
Interference with ERKThr188 phosphorylation impairs pathological but not physiological cardiac hypertrophy.
davide calebiro; Emanuele Cocucci; Alfio Borzi; Finn Rieken; Titiwat Sungkaworn; Julia Wagner; Ulrike Zabel; Alexander Zürn; Martin J Lohse
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization.
Marie Vidal; Thomas Wieland; Martin J Lohse; Kristina Lorenz
β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway.

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2013: Catharina Ruppert; Marie Vidal; Frank Weidemann; Mehmet Oezkur; Katharina Deiss; Armin Gorski; Sebastian Herrmann; Martin J Lohse; Kristina Lorenz
Interference with ERKThr188 phosphorylation impairs pathological but not physiological cardiac hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7440-5.
2013: davide calebiro; Emanuele Cocucci; Alfio Borzi; Finn Rieken; Titiwat Sungkaworn; Julia Wagner; Ulrike Zabel; Alexander Zürn; Martin J Lohse
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):743-8.
2012: Marie Vidal; Thomas Wieland; Martin J Lohse; Kristina Lorenz
β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway.
Cardiovascular research 2012;96(2):255-64.
2012: Veronika Hlavackova; Carsten Hoffmann; Julia Bätz; Jaroslav Blahos; Daniela Frankova; Jean-Philippe Pin; Laurent Prezeau; Ulrike Zabel; Martin J Lohse
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.
Science signaling 2012;5(237):ra59.
2012: Carsten Hoffmann; Catherine H Berlot; Moritz Bünemann; Peter Hein; Susanne Nuber; Christiane Winkler; Ulrike Zabel; Nicole Ziegler; Martin J Lohse
Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells.
Molecular pharmacology 2012;82(2):236-45.
2012: Alexander Emami-Nemini; Antje Gohla; Martin J Lohse; Henning Urlaub; Christoph Klenk
The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling.
Molecular pharmacology 2012;82(2):217-25.
2012: Manuela Ambrosio; Martin J Lohse
Nonequilibrium activation of a G-protein-coupled receptor.
Molecular pharmacology 2012;81(6):770-7.
2012: Ruth C Werthmann; Martin J Lohse; Silvia Volpe; davide calebiro
Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):2043-8.
2012: Martin J Lohse; Susanne Nuber; Carsten Hoffmann
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling.
Pharmacological reviews 2012;64(2):299-336.
2011: Nadine Frölich; Christian Dees; Christian Paetz; Xuan Ren; Martin J Lohse; Viacheslav O Nikolaev; Meinhart H Zenk
Distinct pharmacological properties of morphine metabolites at G(i)-protein and β-arrestin signaling pathways activated by the human μ-opioid receptor.
Biochemical pharmacology 2011;81(10):1248-54.
2011: Sebastian Börner; Frank Schwede; Angela Schlipp; Filip Berisha; davide calebiro; Martin J Lohse; Viacheslav O Nikolaev
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells.
Nature protocols 2011;6(4):427-38.
2011: Jan-Hendrik Spille; Alexander Zürn; Carsten Hoffmann; Martin J Lohse; Gregory S Harms
Rotational diffusion of the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells.
Biophysical journal 2011;100(4):1139-48.
2011: Nicole Ziegler; Julia Bätz; Ulrike Zabel; Martin J Lohse; Carsten Hoffmann
FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors.
Bioorganic & medicinal chemistry 2011;19(3):1048-54.
2011: Manuela Ambrosio; Alexander Zürn; Martin J Lohse
Sensing G protein-coupled receptor activation.
Neuropharmacology 2011;60(1):45-51.
2010: Christoph Klenk; Thorsten Vetter; Alexander Zürn; Jean-Pierre Vilardaga; Peter A Friedman; Bin Wang; Martin J Lohse
Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor.
The Journal of biological chemistry 2010;285(39):30355-62.
2010: Carsten Hoffmann; Guido Gaietta; Alexander Zürn; Stephen R Adams; Sonia Terrillon; Mark H Ellisman; Roger Y Tsien; Martin J Lohse
Fluorescent labeling of tetracysteine-tagged proteins in intact cells.
Nature protocols 2010;5(10):1666-77.
2010: Stefan Jacobs; davide calebiro; Viacheslav O Nikolaev; Martin J Lohse; Stefan Schulz
Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary.
Endocrinology 2010;151(9):4560-5.
2010: Manuela Ambrosio; Martin J Lohse
Microscopy: GPCR dimers moving closer.
Nature chemical biology 2010;6(8):570-1.
2010: davide calebiro; Viacheslav O Nikolaev; Martin J Lohse
Imaging of persistent cAMP signaling by internalized G protein-coupled receptors.
Journal of molecular endocrinology 2010;45(1):1-8.
2010: Alexander Zürn; Christoph Klenk; Ulrike Zabel; Susanne Reiner; Martin J Lohse; Carsten Hoffmann
Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores.
Bioconjugate chemistry 2010;21(5):853-9.
2010: davide calebiro; Viacheslav O Nikolaev; Luca Persani; Martin J Lohse
Signaling by internalized G-protein-coupled receptors.
Trends in pharmacological sciences 2010;31(5):221-8.
2010: Monika Maier-Peuschel; Nadine Frölich; Christian Dees; Leif G Hommers; Carsten Hoffmann; Viacheslav O Nikolaev; Martin J Lohse
A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.
The Journal of biological chemistry 2010;285(12):8793-800.
2010: Christoph Klenk; Stefan Schulz; davide calebiro; Martin J Lohse
Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1.
The Journal of biological chemistry 2010;285(12):8665-74.
2009: Nadine Beetz; Michael D Harrison; Marc Brede; Xiangang Zong; Michal J Urbanski; Anika Sietmann; Jennifer Kaufling; Stefan Lorkowski; Michel Barrot; Mathias W Seeliger; Maria vieira-coelho; Pavel Hamet; Daniel Gaudet; Ondrej Seda; Johanne Tremblay; Theodore A Kotchen; Mary Kaldunski; Rolf M Nüsing; Bela Szabo; Howard J Jacob; Allen W Cowley; Martin Biel; Monika Stoll; Martin J Lohse; Ulrich Broeckel; Lutz Hein
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.
The Journal of clinical investigation 2009;119(12):3597-3612.
2009: Susanne Reiner; Nicole Ziegler; Catherine Leon; Kristina Lorenz; Kathrin von Hayn; Christian Gachet; Martin J Lohse; Carsten Hoffmann
beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites.
Molecular pharmacology 2009;76(6):1162-71.
2009: Kristina Lorenz; Joachim P Schmitt; Marie Vidal; Martin J Lohse
Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling.
The international journal of biochemistry & cell biology 2009;41(12):2351-5.
2009: davide calebiro; Viacheslav O Nikolaev; Maria Cristina Gagliani; Tiziana de Filippis; Christian Dees; Carlo Tacchetti; Luca Persani; Martin J Lohse
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.
PLoS biology 2009;7(8):e1000172.
2009: Sandra Dorsch; Karl-Norbert Klotz; Stefan Engelhardt; Martin J Lohse; Moritz Bünemann
Analysis of receptor oligomerization by FRAP microscopy.
Nature methods 2009;6(3):225-30.
2009: A Zürn; U Zabel; J-P Vilardaga; H Schindelin; Martin J Lohse; C Hoffmann
Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.
Molecular pharmacology 2009;75(3):534-41.
2009: Joachim P Schmitt; Ferhaan Ahmad; Kristina Lorenz; Lutz Hein; Stefan Schulz; Michio Asahi; David H Maclennan; Christine E Seidman; J G Seidman; Martin J Lohse
Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.
Circulation 2009;119(3):436-44.
2009: Geertje Lewin; Marek Matus; Abhijit Basu; Karin Frebel; Sebastian Pius Rohsbach; Andrej Safronenko; Matthias Dodo Seidl; Frank Stümpel; Igor B Buchwalow; Simone Koenig; Stefan Engelhardt; Martin J Lohse; Wilhelm Schmitz; Frank U Müller
Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction.
Circulation 2009;119(1):79-88.
2009: Kristina Lorenz; Joachim P Schmitt; Eva Schmitteckert; Martin J Lohse
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.
Nature medicine 2009;15(1):75-83.
2008: Cornelius Krasel; Ulrike Zabel; Kristina Lorenz; Susanne Reiner; Suleiman Al-Sabah; Martin J Lohse
Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization.
The Journal of biological chemistry 2008;283(46):31840-8.
2008: Carsten Hoffmann; Nicole Ziegler; Susanne Reiner; Cornelius Krasel; Martin J Lohse
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2.
The Journal of biological chemistry 2008;283(45):30933-41.
2008: Martin J Lohse; Christoph Klenk
Blocking them all: beta-arrestins inhibit cellular signaling.
Molecular cell 2008;31(5):619-21.
2008: Roland Jahns; Valérie Boivin; Valentin Schwarzbach; Georg Ertl; Martin J Lohse
Pathological autoantibodies in cardiomyopathy.
Autoimmunity 2008;41(6):454-61.
2008: Stephanie Schlickum; Helga Sennefelder; Mike Friedrich; Gregory Harms; Martin J Lohse; Peter Kilshaw; Michael P Schön
Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion.
Blood 2008;112(3):619-25.
2008: Martin J Lohse; Viacheslav O Nikolaev; Peter Hein; Carsten Hoffmann; Jean-Pierre Vilardaga; Moritz Bünemann
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors.
Trends in pharmacological sciences 2008;29(3):159-65.
2008: Günter Mayer; Bernhard Wulffen; Christian Huber; Jörg Brockmann; Birgit Flicke; Lars Neumann; Doris Hafenbradl; Bert M Klebl; Martin J Lohse; Cornelius Krasel; M Blind
An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro.
RNA (New York, N.Y.) 2008;14(3):524-34.
2008: Martin J Lohse; Peter Hein; Carsten Hoffmann; Viacheslav O Nikolaev; Jean-Pierre Vilardaga; Moritz Bünemann
Kinetics of G-protein-coupled receptor signals in intact cells.
British journal of pharmacology 2008;153 Suppl 1():S125-32.
2008: Carsten Hoffmann; A Zürn; Moritz Bünemann; Martin J Lohse
Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open.
British journal of pharmacology 2008;153 Suppl 1():S358-66.
2008: Jean-Pierre Vilardaga; Viacheslav O Nikolaev; Kristina Lorenz; Sébastien Ferrandon; Zhenjie Zhuang; Martin J Lohse
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.
Nature chemical biology 2008;4(2):126-31.
2007: Martin J Lohse; Moritz Bünemann; Carsten Hoffmann; Jean-Pierre Vilardaga; Viacheslav O Nikolaev
Monitoring receptor signaling by intramolecular FRET.
Current opinion in pharmacology 2007;7(5):547-53.
2007: Viacheslav O Nikolaev; Chotima Boettcher; Christian Dees; Moritz Bünemann; Martin J Lohse; Meinhart H Zenk
Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.
The Journal of biological chemistry 2007;282(37):27126-32.
2007: Viacheslav O Nikolaev; Valérie Boivin; Stefan Störk OR Stoerk; Christiane E Angermann; Georg Ertl; Martin J Lohse; Roland Jahns
A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure.
Journal of the American College of Cardiology 2007;50(5):423-31.
2007: Sabine Merkle; Stefan Frantz; Michael P Schön; Johann Bauersachs; Monika Buitrago; Robert J A Frost; Eva Schmitteckert; Martin J Lohse; Stefan Engelhardt
A role for caspase-1 in heart failure.
Circulation research 2007;100(5):645-53.
2007: Anne Knaus; Xiangang Zong; Nadine Beetz; Roland Jahns; Martin J Lohse; Martin Biel; Lutz Hein
Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine.
Circulation 2007;115(7):872-80.
2007: Martin J Lohse; Carsten Hoffmann; Viacheslav O Nikolaev; Jean-Pierre Vilardaga; Moritz Bünemann
Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells.
Advances in protein chemistry 2007;74():167-88.
2007: Francesca Rochais; Jean-Pierre Vilardaga; Viacheslav O Nikolaev; Moritz Bünemann; Martin J Lohse; Stefan Engelhardt
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol.
The Journal of clinical investigation 2007;117(1):229-35.
2006: Viacheslav O Nikolaev; Moritz Bünemann; Eva Schmitteckert; Martin J Lohse; Stefan Engelhardt
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling.
Circulation research 2006;99(10):1084-91.
2006: Peter Hein; Francesca Rochais; Carsten Hoffmann; Sandra Dorsch; Viacheslav O Nikolaev; Stefan Engelhardt; Catherine H Berlot; Martin J Lohse; Moritz Bünemann
Gs activation is time-limiting in initiating receptor-mediated signaling.
The Journal of biological chemistry 2006;281(44):33345-51.
2006: Stefan Störk OR Stoerk; Valérie Boivin; Rüdiger Horf; Lutz Hein; Martin J Lohse; Christiane E Angermann; Roland Jahns
Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy.
American heart journal 2006;152(4):697-704.
2006: Roland Jahns; Valérie Boivin; Martin J Lohse
Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats.
International journal of cardiology 2006;112(1):7-14.
2006: Viacheslav O Nikolaev; Carsten Hoffmann; Moritz Bünemann; Martin J Lohse; Jean-Pierre Vilardaga
Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer.
The Journal of biological chemistry 2006;281(34):24506-11.
2006: Viacheslav O Nikolaev; Martin J Lohse
Monitoring of cAMP synthesis and degradation in living cells.
Physiology (Bethesda, Md.) 2006;21():86-92.
2006: Christoph Klenk; Jan Humrich; Ursula Quitterer; Martin J Lohse
SUMO-1 controls the protein stability and the biological function of phosducin.
The Journal of biological chemistry 2006;281(13):8357-64.
2006: Roland Jahns; Valérie Boivin; Martin J Lohse
beta(1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy.
Trends in cardiovascular medicine 2006;16(1):20-4.
2005: Peter Hein; Monika Frank; Carsten Hoffmann; Martin J Lohse; Moritz Bünemann
Dynamics of receptor/G protein coupling in living cells.
The EMBO journal 2005;24(23):4106-14.
2005: Marian Castro; Viacheslav O Nikolaev; Dieter Palm; Martin J Lohse; Jean-Pierre Vilardaga
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):16084-9.
2005: Rainer Winstel; Hans-Georg Ihlenfeldt; Günther Jung; Cornelius Krasel; Martin J Lohse
Peptide inhibitors of G protein-coupled receptor kinases.
Biochemical pharmacology 2005;70(7):1001-8.
2005: Monika Buitrago; Kristina Lorenz; Alexander H Maass; Silke Oberdorf-Maass; Ursula Keller; Eva Schmitteckert; Yuri Ivashchenko; Martin J Lohse; Stefan Engelhardt
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
Nature medicine 2005;11(8):837-44.
2005: Monika Frank; Leonore Thümer; Martin J Lohse; Moritz Bünemann
G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.
The Journal of biological chemistry 2005;280(26):24584-90.
2005: Jean-Pierre Vilardaga; Ralf Steinmeyer; Gregory S Harms; Martin J Lohse
Molecular basis of inverse agonism in a G protein-coupled receptor.
Nature chemical biology 2005;1(1):25-8.
2005: Jan Humrich; Christina Bermel; Moritz Bünemann; Linda Härmark; Robert Frost; Ursula Quitterer; Martin J Lohse
Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding.
The Journal of biological chemistry 2005;280(20):20042-50.
2005: Torsten Frambach; Thomas Müller; Sebastian Freund; Stefan Engelhardt; Marc Sütterlin; Martin J Lohse; Johannes Dietl
Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling.
The Journal of clinical endocrinology and metabolism 2005;90(5):2882-7.
2005: Cornelius Krasel; Moritz Bünemann; Kristina Lorenz; Martin J Lohse
Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation.
The Journal of biological chemistry 2005;280(10):9528-35.
2005: Carsten Hoffmann; Guido Gaietta; Moritz Bünemann; Stephen R Adams; Silke Oberdorff-Maass; Björn Behr; Jean-Pierre Vilardaga; Roger Y Tsien; Mark H Ellisman; Martin J Lohse
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells.
Nature methods 2005;2(3):171-6.
2005: Viacheslav O Nikolaev; Stepan Gambaryan; Stefan Engelhardt; Ulrich Walter; Martin J Lohse
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis.
The Journal of biological chemistry 2005;280(3):1716-9.
2004: Cornelius Krasel; Jean-Pierre Vilardaga; Moritz Bünemann; Martin J Lohse
Kinetics of G-protein-coupled receptor signalling and desensitization.
Biochemical Society transactions 2004;32(Pt 6):1029-31.
2004: Viacheslav O Nikolaev; Moritz Bünemann; Lutz Hein; Annette Hannawacker; Martin J Lohse
Novel single chain cAMP sensors for receptor-induced signal propagation.
The Journal of biological chemistry 2004;279(36):37215-8.
2004: Marco Mongillo; Theresa McSorley; Sandrine Evellin; Arvind Sood; Valentina Lissandron; Anna Terrin; Elaine Huston; Annette Hannawacker; Martin J Lohse; Tullio Pozzan; Miles D Houslay; Manuela Zaccolo
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Circulation research 2004;95(1):67-75.
2004: Roland Jahns; Valérie Boivin; Lutz Hein; Sven Triebel; Christiane E Angermann; Georg Ertl; Martin J Lohse
Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy.
The Journal of clinical investigation 2004;113(10):1419-29.
2004: Uwe Kirchhefer; Larry R Jones; Frank Begrow; Peter Boknik; Lutz Hein; Martin J Lohse; Burkhard Riemann; Wilhelm Schmitz; Jörg Stypmann; Joachim Neumann
Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists.
Cardiovascular research 2004;62(1):122-34.
2004: Martin J Lohse
Beta-adrenoceptor polymorphisms and heart failure.
Trends in molecular medicine 2004;10(2):55-8.
2004: C Hoffmann; M R Leitz; Silke Oberdorf-Maass; Martin J Lohse; Karl-Norbert Klotz
Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(2):151-9.
2004: K O Schwab; U Menche; G Schmeisl; Martin J Lohse
Hypoglycemia-dependent beta2-adrenoceptor downregulation: a contributing factor to hypoglycemia unawareness in patients with Type-1 diabetes?
Hormone research 2004;62(3):137-41.
2003: Moritz Bünemann; Monika Frank; Martin J Lohse
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):16077-82.
2003: Martin J Lohse; Jean-Pierre Vilardaga; Moritz Bünemann
Direct optical recording of intrinsic efficacy at a G protein-coupled receptor.
Life sciences 2003;74(2-3):397-404.
2003: Kristina Lorenz; Martin J Lohse; Ursula Quitterer
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.
Nature 2003;426(6966):574-9.
2003: Martin Eigenthaler; Stefan Engelhardt; Birgitta Schinke; Anna Kobsar; Eva Schmitteckert; Stepan Gambaryan; Catherine M Engelhardt; Veit Krenn; Marina Eliava; Thomas Jarchau; Martin J Lohse; Ulrich Walter; Lutz Hein
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2471-81.
2003: Martin J Lohse; Jean-Pierre Vilardaga; Moritz Bünemann
Molecular mechanisms of receptor activation: real-time analysis by fluorescence resonance energy transfer.
Autonomic & autacoid pharmacology 2003;23(4):231-3.
2003: Marc Brede; Gabor Nagy; Melanie Philipp; Jakob B Sorensen; Martin J Lohse; Lutz Hein
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes.
Molecular endocrinology (Baltimore, Md.) 2003;17(8):1640-6.
2003: Jean-Pierre Vilardaga; Moritz Bünemann; Cornelius Krasel; Marian Castro; Martin J Lohse
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells.
Nature biotechnology 2003;21(7):807-12.
2003: Matthias Spindler; Stefan Engelhardt; Reinhard Niebler; Helga Wagner; Lutz Hein; Martin J Lohse; Stefan Neubauer
Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice.
Journal of molecular and cellular cardiology 2003;35(4):389-97.
2003: Jutta Hessling; Martin J Lohse; Karl-Norbert Klotz
Peptide G protein agonists from a phage display library.
Biochemical pharmacology 2003;65(6):961-7.
2003: Tanja Eichmann; Kristina Lorenz; Michaela Hoffmann; Jörg Brockmann; Cornelius Krasel; Martin J Lohse; Ursula Quitterer
The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site.
The Journal of biological chemistry 2003;278(10):8052-7.
2003: Jan Humrich; Christina Bermel; Tobias Grubel; Ursula Quitterer; Martin J Lohse
Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing.
The Journal of biological chemistry 2003;278(7):4474-81.
2003: Leif G Hommers; Martin J Lohse; Moritz Bünemann
Regulation of the inward rectifying properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta gamma subunits.
The Journal of biological chemistry 2003;278(2):1037-43.
2002: Annette Hannawacker; Cornelius Krasel; Martin J Lohse
Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor.
Molecular pharmacology 2002;62(6):1431-7.
2002: Marc Brede; Frank Wiesmann; Roland Jahns; Kerstin Hadamek; Carsten Arnolt; Stefan Neubauer; Martin J Lohse; Lutz Hein
Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure.
Circulation 2002;106(19):2491-6.
2002: Marian Castro; Frank Dicker; Jean-Pierre Vilardaga; Cornelius Krasel; Manfred Bernhardt; Martin J Lohse
Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins.
Endocrinology 2002;143(10):3854-65.
2002: Melanie Philipp; Marc Brede; Kerstin Hadamek; Manfred Gessler; Martin J Lohse; Lutz Hein
Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.
Nature genetics 2002;31(3):311-5.
2002: Stefan Engelhardt; Lutz Hein; Ursula Keller; Kerstin Klämbt; Martin J Lohse
Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice.
Circulation research 2002;90(7):814-9.
2002: Jean-Pierre Vilardaga; Cornelius Krasel; Stéphanie Chauvin; Tom Bambino; Martin J Lohse; Robert A Nissenson
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association.
The Journal of biological chemistry 2002;277(10):8121-9.
2001: Moritz Bünemann; M M Bücheler; Melanie Philipp; Martin J Lohse; Lutz Hein
Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents.
The Journal of biological chemistry 2001;276(50):47512-7.
2001: Stefan Engelhardt; Peter Boknik; Ursula Keller; Joachim Neumann; Martin J Lohse; Lutz Hein
Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2718-20.
2001: Marc Brede; Kerstin Hadamek; Lorenz Meinel; Frank Wiesmann; J Peters; Stefan Engelhardt; Andreas Simm; Axel Haase; Martin J Lohse; Lutz Hein
Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor.
Circulation 2001;104(21):2602-7.
2001: AJ Chruscinski; Marc Brede; Lorenz Meinel; Martin J Lohse; Brian K Kobilka; Lutz Hein
Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors.
Molecular pharmacology 2001;60(5):955-62.
2001: Stefan Engelhardt; Y Grimmer; G H Fan; Martin J Lohse
Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice.
Molecular pharmacology 2001;60(4):712-7.
2001: Jean-Pierre Vilardaga; Monika Frank; Cornelius Krasel; Christian Dees; Robert A Nissenson; Martin J Lohse
Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein.
The Journal of biological chemistry 2001;276(36):33435-43.
2001: Frank Wiesmann; J Ruff; Stefan Engelhardt; Lutz Hein; Charlotte Dienesch; A Leupold; Ralf Illinger; Alex Frydrychowicz; Karl-Heinz Hiller; Eberhard Rommel; Axel Haase; Martin J Lohse; Stefan Neubauer
Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts.
Circulation research 2001;88(6):563-9.
2001: Ursula Quitterer; M Hoffmann; Marc Freichel; Martin J Lohse
Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits.
The Journal of biological chemistry 2001;276(9):6763-9.
2001: Valérie Boivin; Roland Jahns; Stepan Gambaryan; Winfried Ness; Fritz Boege; Martin J Lohse
Immunofluorescent imaging of beta 1- and beta 2-adrenergic receptors in rat kidney.
Kidney international 2001;59(2):515-31.
2001: Cornelius Krasel; S Dammeier; Rainer Winstel; J Brockmann; Mischak Harald; Martin J Lohse
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
The Journal of biological chemistry 2001;276(3):1911-5.
2000: Stefan Hammerschmidt; M Bell; N Büchler; Hans Wahn; Helga Remkes; Martin J Lohse; Stefan Neubauer
Acute changes of myocardial creatine kinase gene expression under beta-adrenergic stimulation.
Biochimica et biophysica acta 2000;1502(3):471-80.
2000: S Schröder; Martin J Lohse
Quantification of the tissue levels and function of the G-protein regulator phosducin-like protein (PhlP).
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(4-5):435-9.
2000: Roland Jahns; Valérie Boivin; T Krapf; G Wallukat; Fritz Boege; Martin J Lohse
Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies.
Journal of the American College of Cardiology 2000;36(4):1280-7.
2000: Ana Ruiz-Gómez; Jan Humrich; Cristina Murga; Ursula Quitterer; Martin J Lohse; Federico Mayor
Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.
The Journal of biological chemistry 2000;275(38):29724-30.
1999: Roland Jahns; Valérie Boivin; C Siegmund; Fritz Boege; Martin J Lohse; Gerhard Inselmann
Activating beta-1-adrenoceptor antibodies are not associated with cardiomyopathies secondary to valvular or hypertensive heart disease.
Journal of the American College of Cardiology 1999;34(5):1545-51.
1999: Ursula Quitterer; Martin J Lohse
Crosstalk between Galpha(i)- and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10626-31.
1999: Joseph Slupsky; Ursula Quitterer; Christoph K Weber; P Gierschik; Martin J Lohse; Ulf R Rapp
Binding of Gbetagamma subunits to cRaf1 downregulates G-protein-coupled receptor signalling.
Current biology : CB 1999;9(17):971-4.
1999: Stefan Engelhardt; Lutz Hein; Frank Wiesmann; Martin J Lohse
Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7059-64.
1999: F Dicker; Ursula Quitterer; Rainer Winstel; K Honold; Martin J Lohse
Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5476-81.
1999: Roland Jahns; Valérie Boivin; C Siegmund; Gerhard Inselmann; Martin J Lohse; Fritz Boege
Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure.
Circulation 1999;99(5):649-54.
1999: S Danner; Martin J Lohse
Regulation of beta-adrenergic receptor responsiveness modulation of receptor gene expression.
Reviews of physiology, biochemistry and pharmacology 1999;136():183-223.
1998: P H Bauer; K Blüml; S Schröder; J Hegler; Christian Dees; Martin J Lohse
Interactions of phosducin with the subunits of G-proteins. Binding to the alpha as well as the betagamma subunits.
The Journal of biological chemistry 1998;273(16):9465-71.
1998: P H Bauer; Martin J Lohse
Effects of phosducin on the GTPase cycle of Go.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(4):371-7.
1998: Stefan Neubauer; M Frank; Kai Hu; Helga Remkes; A Laser; Michael Horn; Georg Ertl; Martin J Lohse
Changes of creatine kinase gene expression in rat heart post-myocardial infarction.
Journal of molecular and cellular cardiology 1998;30(4):803-10.
1998: S Danner; Monika Frank; Martin J Lohse
Agonist regulation of human beta2-adrenergic receptor mRNA stability occurs via a specific AU-rich element.
The Journal of biological chemistry 1998;273(6):3223-9.
1998: Karl-Norbert Klotz; J Hessling; J Hegler; C Owman; Björn Kull; Bertil B. Fredholm; Martin J Lohse
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(1):1-9.
1997: A M Gabilondo; J Hegler; Cornelius Krasel; V Boivin-Jahns; Lutz Hein; Martin J Lohse
A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12285-90.
1997: Roland Jahns; C Siegmund; V Jahns; Helmut Reiländer; A Maidhof; W Müller-Esterl; Martin J Lohse; Fritz Boege
Probing human beta1- and beta2 -adrenoceptors with domain-specific fusion protein antibodies.
European journal of pharmacology 1997;334(1):115-26.
1997: K Blüml; W Schnepp; S Schröder; M Beyermann; M Macias; H Oschkinat; Martin J Lohse
A small region in phosducin inhibits G-protein betagamma-subunit function.
The EMBO journal 1997;16(16):4908-15.
1997: S Danner; Martin J Lohse
Cell type-specific regulation of beta2-adrenoceptor mRNA by agonists.
European journal of pharmacology 1997;331(1):73-8.
1997: Stefan Engelhardt; W Zieger; J Kassubek; M C Michel; Martin J Lohse; Otto-Erich Brodde
Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium.
The Journal of clinical endocrinology and metabolism 1997;82(4):1235-42.
1997: P Söhlemann; J Soppa; D Oesterhelt; Martin J Lohse
Expression of beta 2-adrenoceptors in halobacteria.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(2):150-60.
1997: S Schröder; K Blüml; Christian Dees; Martin J Lohse
Identification of a C-terminal binding site for G-protein betagamma-subunits in phosducin-like protein.
FEBS letters 1997;401(2-3):243-6.
1997: S Müller; A Straub; Martin J Lohse
Selectivity of beta-adrenergic receptor kinase 2 for G protein betagamma subunits.
FEBS letters 1997;401(1):25-9.
1996: Roland Jahns; C Siegmund; V Jahns; Helmut Reiländer; A Maidhof; W Müller-Esterl; Martin J Lohse; Fritz Boege
Probing human beta 1- and beta 2-adrenoceptors with domain-specific fusion protein antibodies.
European journal of pharmacology 1996;316(1):111-21.
1996: Martin J Lohse; K Blüml; S Danner; C Krasel
Regulators of G-protein-mediated signalling.
Biochemical Society transactions 1996;24(4):975-80.
1996: S Danner; Martin J Lohse
Phosducin is a ubiquitous G-protein regulator.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10145-50.
1996: K Schulz; S Danner; P Bauer; S Schröder; Martin J Lohse
Expression of phosducin in a phosducin-negative cell line reveals functions of a Gbetagamma-binding protein.
The Journal of biological chemistry 1996;271(37):22546-51.
1996: K Wieland; H M Zuurmond; C Krasel; A P Ijzerman; Martin J Lohse
Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9276-81.
1996: A M Gabilondo; C Krasel; Martin J Lohse
Mutations of Tyr326 in the beta 2-adrenoceptor disrupt multiple receptor functions.
European journal of pharmacology 1996;307(2):243-50.
1996: Sylke Müller; A Straub; S Schröder; P H Bauer; Martin J Lohse
Interactions of phosducin with defined G protein beta gamma-subunits.
The Journal of biological chemistry 1996;271(20):11781-6.
1996: Martin J Lohse; C Krasel; R Winstel; F Mayor
G-protein-coupled receptor kinases.
Kidney international 1996;49(4):1047-52.
1996: R Winstel; S Freund; C Krasel; E Hoppe; Martin J Lohse
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2105-9.
1996: S Schröder; Martin J Lohse
Inhibition of G-protein betagamma-subunit functions by phosducin-like protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2100-4.
1996: Martin J Lohse; Stefan Engelhardt; S Danner; M Böhm
Mechanisms of beta-adrenergic receptor desensitization: from molecular biology to heart failure.
Basic research in cardiology 1996;91 Suppl 2():29-34.
1996: S Engelhardt; M Böhm; E Erdmann; Martin J Lohse
Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: progressive reduction of beta 1-adrenergic receptor mRNA in heart failure.
Journal of the American College of Cardiology 1996;27(1):146-54.
1995: P Söhlemann; M Hekman; M Puzicha; C Buchen; Martin J Lohse
Binding of purified recombinant beta-arrestin to guanine-nucleotide-binding-protein-coupled receptors.
European journal of biochemistry / FEBS 1995;232(2):464-72.
1995: S Pippig; S Andexinger; Martin J Lohse
Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.
Molecular pharmacology 1995;47(4):666-76.
1995: Martin J Lohse
G-protein-coupled receptor kinases and the heart.
Trends in cardiovascular medicine 1995;5(2):63-8.
1995: S Müller; Martin J Lohse
The role of G-protein beta gamma subunits in signal transduction.
Biochemical Society transactions 1995;23(1):141-8.
1994: M Hekman; P H Bauer; P Söhlemann; Martin J Lohse
Phosducin inhibits receptor phosphorylation by the beta-adrenergic receptor kinase in a PKA-regulated manner.
FEBS letters 1994;343(2):120-4.
1994: M Ungerer; G Parruti; M Böhm; M Puzicha; A DeBlasi; E Erdmann; Martin J Lohse
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.
Circulation research 1994;74(2):206-13.
1993: Sylke Müller; M Hekman; Martin J Lohse
Specific enhancement of beta-adrenergic receptor kinase activity by defined G-protein beta and gamma subunits.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10439-43.
1993: Martin J Lohse
Molecular mechanisms of membrane receptor desensitization.
Biochimica et biophysica acta 1993;1179(2):171-88.
1993: P Söhlemann; M Hekman; C Buchen; J S Elce; Martin J Lohse
Purification and functional characterization of beta-adrenergic receptor kinase expressed in insect cells.
FEBS letters 1993;324(1):59-62.
1993: S Pippig; S Andexinger; K Daniel; M Puzicha; Marc G Caron; R J Lefkowitz; Martin J Lohse
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.
The Journal of biological chemistry 1993;268(5):3201-8.
1993: M Ungerer; M Böhm; J S Elce; E Erdmann; Martin J Lohse
Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.
Circulation 1993;87(2):454-63.
1992: M Ungerer; B Obermaier-Skrobranek; Martin J Lohse
Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats.
European journal of pharmacology 1992;226(4):381-2.
1992: P H Bauer; Sylke Müller; M Puzicha; S Pippig; B Obermaier; E J Helmreich; Martin J Lohse
Phosducin is a protein kinase A-regulated G-protein regulator.
Nature 1992;358(6381):73-6.
1992: Martin J Lohse; S Andexinger; J Pitcher; S Trukawinski; J Codina; J P Faure; Marc G Caron; R J Lefkowitz
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
The Journal of biological chemistry 1992;267(12):8558-64.
1992: Martin J Lohse
Stable overexpression of human beta 2-adrenergic receptors in mammalian cells.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(4):444-51.