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Franck Barrat

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Lupus Erythematosus, Systemic

Physiology

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Publications

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Cristiana Guiducci; Claudio Tripodo; Mei Gong; Sabina Sangaletti; Mario P Colombo; Robert L Coffman; Franck J Barrat
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.
Xiaoping Qing; Milena Pitashny; David B Thomas; Franck J Barrat; Mark P Hogarth; Chaim Putterman
Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury.
Judith N Mandl; Ashley P Barry; Thomas H Vanderford; Natalia Kozyr; Rahul Chavan; Sara Klucking; Franck J Barrat; Robert L Coffman; Silvija I Staprans; Mark B Feinberg
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.

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All Publications

2010: Cristiana Guiducci; Claudio Tripodo; Mei Gong; Sabina Sangaletti; Mario P Colombo; Robert L Coffman; Franck J Barrat
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.
The Journal of experimental medicine 2010;207(13):2931-42.
2008: Xiaoping Qing; Milena Pitashny; David B Thomas; Franck J Barrat; Mark P Hogarth; Chaim Putterman
Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury.
Immunology letters 2008;121(1):61-73.
2008: Judith N Mandl; Ashley P Barry; Thomas H Vanderford; Natalia Kozyr; Rahul Chavan; Sara Klucking; Franck J Barrat; Robert L Coffman; Silvija I Staprans; Mark B Feinberg
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.
Nature medicine 2008;14(10):1077-87.
2008: Franck J Barrat; Robert L Coffman
Development of TLR inhibitors for the treatment of autoimmune diseases.
Immunological reviews 2008;223():271-83.
2008: Anne O'Garra; Franck J Barrat; Antonio G Castro; Alain Vicari; Catherine Hawrylowicz
Strategies for use of IL-10 or its antagonists in human disease.
Immunological reviews 2008;223():114-31.
2008: Cristiana Guiducci; Cristina Ghirelli; Marie-Annick Marloie-Provost; Tracy Matray; Robert L Coffman; Yong-Jun Liu; Franck J Barrat; Vassili Soumelis
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.
The Journal of experimental medicine 2008;205(2):315-22.
2007: Franck J Barrat; Thea Meeker; Jean H Chan; Cristiana Guiducci; Robert L Coffman
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.
European journal of immunology 2007;37(12):3582-6.
2007: Michael F Denny; Seth Thacker; Hemal Mehta; Emily Somers; Todd Dodick; Franck J Barrat; W Joseph McCune; Mariana J Kaplan
Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis.
Blood 2007;110(8):2907-15.
2007: Lionel Apetoh; François Ghiringhelli; Antoine Tesniere; Michel Obeid; Carla Ortiz; Alfredo Criollo; Grégoire Mignot; M Chiara Maiuri; Evelyn Ullrich; Patrick Saulnier; Huan Yang; Sebastian Amigorena; Bernhard RYFFEL; Franck J Barrat; Paul Saftig; Francis Levi; Rosette Lidereau; Catherine Nogues; Jean-Paul Mira; Agnès Chompret; Virginie Joulin; Françoise Clavel-Chapelon; Jean Bourhis; Fabrice André; Suzette Delaloge; Thomas Tursz; Guido Kroemer; Laurence Zitvogel
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Nature medicine 2007;13(9):1050-9.
2007: Holger Kanzler; Franck J Barrat; Edith M Hessel; Robert L Coffman
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.
Nature medicine 2007;13(5):552-9.
2006: Cristiana Guiducci; Gary Ott; Jean H Chan; Emily Damon; Carlo Calacsan; Tracy Matray; Kyung-Dall Lee; Robert L Coffman; Franck J Barrat
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation.
The Journal of experimental medicine 2006;203(8):1999-2008.
2006: Emmanuel Xystrakis; Siddharth Kusumakar; Sandra Boswell; Emma Peek; Zoë Urry; David F Richards; Tonye Adikibi; Carol Pridgeon; Margaret Dallman; Tuck-Kay Loke; Douglas S Robinson; Franck J Barrat; Anne O'Garra; Paul Lavender; Tak H Lee; Christopher J Corrigan; Catherine M Hawrylowicz
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
The Journal of clinical investigation 2006;116(1):146-55.
2005: Kun Yang; Anne Puel; Shenying Zhang; Céline Eidenschenk; Cheng-Lung KU; Armanda Casrouge; Capucine Picard; Horst von Bernuth; Brigitte Senechal; Sabine Plancoulaine; Sami Al-Hajjar; Abdulaziz Al-Ghonaium; László Maródi; Donald Davidson; David P Speert; Chaim M Roifman; Ben-Zion Garty; Adrian Ozinsky; Franck J Barrat; Robert L Coffman; Richard L Miller; Xiaoxia Li; Pierre Lebon; Carlos Rodriguez-Gallego; Helen Chapel; Frederic Geissmann; Emmanuelle Jouanguy; Jean-Laurent Casanova
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.
Immunity 2005;23(5):465-78.
2005: Franck J Barrat; Thea Meeker; Josh Gregorio; Jean H Chan; Satoshi Uematsu; Shizuo Akira; Bonnie Chang; Omar Duramad; Robert L Coffman
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.
The Journal of experimental medicine 2005;202(8):1131-9.
2005: Omar Duramad; Karen L Fearon; Bonnie Chang; Jean H Chan; Josh Gregorio; Robert L Coffman; Franck J Barrat
Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5193-200.
2004: Paulo Vieira; Jillian R Christensen; Sophie Minaee; Emma J O'Neill; Franck J Barrat; André Boonstra; Thomas Barthlott; Brigitta Stockinger; David C Wraith; Anne O'Garra
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5986-93.
2003: Omar Duramad; Karen L Fearon; Jean H Chan; Holger Kanzler; Jason Marshall; Robert L Coffman; Franck J Barrat
IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences.
Blood 2003;102(13):4487-92.
2003: Anne O'Garra; Franck J Barrat
In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines.
Immunology letters 2003;85(2):135-9.
2002: Franck J Barrat; Daniel J Cua; André Boonstra; David F Richards; Chad Crain; Huub F Savelkoul; Rene de Waal Malefyt; Robert L Coffman; Catherine M Hawrylowicz; Anne O'Garra
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
The Journal of experimental medicine 2002;195(5):603-16.
2001: André Boonstra; Franck J Barrat; Chad Crain; Victoria L Heath; H F Savelkoul; Anne O'Garra
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4974-80.
2001: Maggie Neighbors; X Xu; Franck J Barrat; S R Ruuls; Tatyana Churakova; R Debets; J. Fernando Bazan; Robert A Kastelein; JS Abrams; Anne O'Garra
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.
The Journal of experimental medicine 2001;194(3):343-54.
2001: Stephen W Chensue; Nicholas W Lukacs; TY Yang; Xiaozhou Shang; Kirsten A Frait; Steven Kunkel; Ted T Kung; Maria T Wiekowski; Joseph A Hedrick; Donald N Cook; Alessandra Zingoni; Satwant K Narula; Albert Zlotnik; Franck J Barrat; Anne O'Garra; M Napolitano; sergio lira
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.
The Journal of experimental medicine 2001;193(5):573-84.
2000: Victoria L Heath; L Showe; Chad Crain; Franck J Barrat; Giorgio Trinchieri; Anne O'Garra
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2861-5.