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Angela Lombardi

Research Profile

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TOP 3
Marina Faiella; Wilfred R Hagen; Liliana Lista; Angela Lombardi; Ornella Maglio; Flavia Nastri; Vincenzo Pavone
De novo design, synthesis and characterisation of MP3, a new catalytic four-helix bundle hemeprotein.
Flavia Nastri; Liliana Lista; Paola Ringhieri; Rosa Vitale; Marina Faiella; Concetta Andreozzi; Paola Travascio; Ornella Maglio; Angela Lombardi; Vincenzo Pavone
A heme-peptide metalloenzyme mimetic with natural peroxidase-like activity.
Rafael Torres Martin de Rosales; Marina Faiella; Erik Farquhar; Lawrence Que; Concetta Andreozzi; Vincenzo Pavone; Ornella Maglio; Flavia Nastri; Angela Lombardi
Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions.

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All Publications

2012: Marina Faiella; Wilfred R Hagen; Liliana Lista; Angela Lombardi; Ornella Maglio; Flavia Nastri; Vincenzo Pavone
De novo design, synthesis and characterisation of MP3, a new catalytic four-helix bundle hemeprotein.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(50):15960-71.
2011: Flavia Nastri; Liliana Lista; Paola Ringhieri; Rosa Vitale; Marina Faiella; Concetta Andreozzi; Paola Travascio; Ornella Maglio; Angela Lombardi; Vincenzo Pavone
A heme-peptide metalloenzyme mimetic with natural peroxidase-like activity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(16):4444-53.
2010: Rafael Torres Martin de Rosales; Marina Faiella; Erik Farquhar; Lawrence Que; Concetta Andreozzi; Vincenzo Pavone; Ornella Maglio; Flavia Nastri; Angela Lombardi
Spectroscopic and metal-binding properties of DF3: an artificial protein able to accommodate different metal ions.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(5):717-28.
2009: Marina Faiella; Concetta Andreozzi; Rafael Torres Martin de Rosales; Vincenzo Pavone; Ornella Maglio; Flavia Nastri; William F DeGrado; Angela Lombardi
An artificial di-iron oxo-protein with phenol oxidase activity.
Nature chemical biology 2009;5(12):882-4.
2008: Angela Cassese; Iolanda Esposito; Francesca Fiory; Alessia P. Barbagallo; Flora Paturzo; Paola Mirra; Luca Ulianich; Ferdinando Giacco; Claudia Iadicicco; Angela Lombardi; Francesco Oriente; Emmanuel Van Obberghen; Francesco Beguinot; Pietro Formisano; Claudia Miele
In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.
The Journal of biological chemistry 2008;283(52):36088-99.
2005: Silvano Geremia; Luigi Di Costanzo; Lucio Randaccio; Donald E Engel; Angela Lombardi; Flavia Nastri; William F DeGrado
Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography.
Journal of the American Chemical Society 2005;127(49):17266-76.
2005: Ornella Maglio; Flavia Nastri; Jennifer R Calhoun; Stephen Lahr; HERSCHEL WADE; Vincenzo Pavone; William F DeGrado; Angela Lombardi
Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(5):539-49.
2005: Steven J Lahr; Donald E Engel; Steven E Stayrook; Ornella Maglio; Benjamin North; Silvano Geremia; Angela Lombardi; William F DeGrado
Analysis and design of turns in alpha-helical hairpins.
Journal of molecular biology 2005;346(5):1441-54.
2005: Jennifer R Calhoun; Flavia Nastri; Ornella Maglio; Vincenzo Pavone; Angela Lombardi; William F DeGrado
Artificial diiron proteins: from structure to function.
Biopolymers 2005;80(2-3):264-78.
2004: Luigi Di Costanzo; Silvano Geremia; Lucio Randaccio; Flavia Nastri; Ornella Maglio; Angela Lombardi; Vincenzo Pavone
Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):1017-27.
2003: Angela Lombardi; Flavia Nastri; Daniela Marasco; Ornella Maglio; Giampiero De Sanctis; Federica Sinibaldi; Roberto Santucci; Massimo Coletta; Vincenzo Pavone
Design of a new mimochrome with unique topology.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(22):5643-54.
2003: Ornella Maglio; Flavia Nastri; Vincenzo Pavone; Angela Lombardi; William F DeGrado
Preorganization of molecular binding sites in designed diiron proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3772-7.
2003: William F DeGrado; Luigi Di Costanzo; Silvano Geremia; Angela Lombardi; Vincenzo Pavone; Lucio Randaccio
Sliding helix and change of coordination geometry in a model di-MnII protein.
Angewandte Chemie (International ed. in English) 2003;42(4):417-20.
2001: Luigi Di Costanzo; HERSCHEL WADE; Silvano Geremia; Lucio Randaccio; Vincenzo Pavone; William F DeGrado; Angela Lombardi
Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center.
Journal of the American Chemical Society 2001;123(51):12749-57.
2001: Angela Lombardi; Flavia Nastri; Vincenzo Pavone
Peptide-based heme-protein models.
Chemical reviews 2001;101(10):3165-89.
2000: Angela Lombardi; Daniela Marasco; Ornella Maglio; Luigi Di Costanzo; Flavia Nastri; Vincenzo Pavone
Miniaturized metalloproteins: application to iron-sulfur proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11922-7.
2000: Angela Lombardi; C M Summa; Silvano Geremia; Lucio Randaccio; Vincenzo Pavone; William F DeGrado
Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6298-305.
2000: Giuseppina De simone; Angela Lombardi; stefania galdiero; Flavia Nastri; Luigi Di Costanzo; S Gohda; A Sano; T Yamada; Vincenzo Pavone
The crystal structure of a Dcp-containing peptide.
Biopolymers 2000;53(2):182-8.
2000: Vincenzo Pavone; Angela Lombardi; Michele Saviano; Giuseppina De simone; Flavia Nastri; Ornella Maglio; Y Omote; Y Yamanaka; T Yamada
Conformational behavior of C alpha,alpha-diphenyl glycine: extended conformation in tripeptides containing consecutive D phi G residues.
Biopolymers 2000;53(2):161-8.
2000: Angela Lombardi; Giuseppina De simone; stefania galdiero; Flavia Nastri; Luigi Di Costanzo; K Makihira; T Yamada; Vincenzo Pavone
The crystal structure of Afc-containing peptides.
Biopolymers 2000;53(2):150-60.
1999: Christopher M Summa; Angela Lombardi; Mitchell Lewis; William F DeGrado
Tertiary templates for the design of diiron proteins.
Current opinion in structural biology 1999;9(4):500-8.
1999: Giuseppina De simone; Giuseppe Manco; stefania galdiero; Angela Lombardi; Mosè Rossi; Vincenzo Pavone
Crystallization and preliminary X-ray diffraction studies of the carboxylesterase EST2 from Alicyclobacillus acidocaldarius.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 7):1348-9.
1999: William F DeGrado; C M Summa; Vincenzo Pavone; Flavia Nastri; Angela Lombardi
De novo design and structural characterization of proteins and metalloproteins.
Annual review of biochemistry 1999;68():779-819.
1999: Angela Lombardi; Giuseppina De simone; stefania galdiero; Norma Staiano; Flavia Nastri; Vincenzo Pavone
From natural to synthetic multisite thrombin inhibitors.
Biopolymers 1999;51(1):19-39.
1999: Angela Lombardi; Giuseppina De simone; Flavia Nastri; stefania galdiero; Rossella Della Morte; Norma Staiano; Carlo Pedone; M Bolognesi; Vincenzo Pavone
The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode.
Protein science : a publication of the Protein Society 1999;8(1):91-5.
1998: Giovanna Ghirlanda; James D Lear; Angela Lombardi; William F DeGrado
From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin.
Journal of molecular biology 1998;281(2):379-91.
1998: Vincenzo Pavone; Giuseppina De simone; Flavia Nastri; stefania galdiero; Norma Staiano; Angela Lombardi; Carlo Pedone
Multiple binding mode of reversible synthetic thrombin inhibitors. A comparative structural analysis.
Biological chemistry 1998;379(8-9):987-1006.
1998: Angela Lombardi; Bruno D'Agostino; Amelia Filippelli; Carlo Pedone; Maria Gabriella Matera; M Falciani; M De Rosa; Francesca Rossi; Vincenzo Pavone
Neuronorm is a potent and water soluble neurokinin A receptor antagonist.
Bioorganic & medicinal chemistry letters 1998;8(13):1735-40.
1998: Angela Lombardi; Bruno D'Agostino; Flavia Nastri; Luigi D'Andrea; Amelia Filippelli; M Falciani; Francesca Rossi; Vincenzo Pavone
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.
Bioorganic & medicinal chemistry letters 1998;8(10):1153-6.
1998: Vincenzo Pavone; Angela Lombardi; Michele Saviano; Flavia Nastri; Laura Zaccaro; Ornella Maglio; Carlo Pedone; Y Omote; Y Yamanaka; T Yamada
Conformational behaviour of C(alpha,alpha)-diphenylglycine: folded vs. extended structures in DphiG-containing tripeptides.
Journal of peptide science : an official publication of the European Peptide Society 1998;4(1):21-32.
1998: Giuseppina De simone; Angela Lombardi; stefania galdiero; Flavia Nastri; Rossella Della Morte; Norma Staiano; Carlo Pedone; M Bolognesi; Vincenzo Pavone
Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
Protein science : a publication of the Protein Society 1998;7(2):243-53.
1998: Flavia Nastri; Angela Lombardi; Luigi D'Andrea; Marina Sanseverino; Ornella Maglio; Vincenzo Pavone
Miniaturized hemoproteins.
Biopolymers 1998;47(1):5-22.
1996: Vincenzo Pavone; G Gaeta; Angela Lombardi; Flavia Nastri; Ornella Maglio; C Isernia; Michele Saviano
Discovering protein secondary structures: classification and description of isolated alpha-turns.
Biopolymers 1996;38(6):705-21.
1996: Angela Lombardi; Michele Saviano; Flavia Nastri; Ornella Maglio; M Mazzeo; C Isernia; Livio Paolillo; Vincenzo Pavone
Solvent-mediated conformational transition in beta-alanine containing cyclic peptides. VIII.
Biopolymers 1996;38(6):693-703.
1996: Angela Lombardi; Michele Saviano; Flavia Nastri; Ornella Maglio; M Mazzeo; Carlo Pedone; C Isernia; Vincenzo Pavone
Unusual conformational preferences of beta-alanine containing cyclic peptides. VII.
Biopolymers 1996;38(6):683-91.
1996: Angela Lombardi; Flavia Nastri; Rossella Della Morte; A Rossi; A De Rosa; Norma Staiano; Carlo Pedone; Vincenzo Pavone
Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors.
Journal of medicinal chemistry 1996;39(10):2008-17.
1996: Angela Lombardi; G D'Auria; Michele Saviano; Ornella Maglio; Flavia Nastri; L Quartara; Carlo Pedone; Vincenzo Pavone
Bicyclic peptides as type I/type II beta-turn scaffolds.
Biopolymers 1996;40(5):505-18.
1996: Angela Lombardi; J W Bryson; W F DeGrado
De novo design of heterotrimeric coiled coils.
Biopolymers 1996;40(5):495-504.
1995: Benedetto Di Blasio; V Del Duca; Angela Lombardi; Carlo Pedone; G P Lorenzi; Ettore Benedetti
Conformation and structure of linear peptides with regularly alternating L- and D-residues: structure of the blocked hexapeptide tert-butyloxycarbonyl-(D-alloisoleucyl-L-isoleucyl)3 methyl ester monohydrate.
International journal of peptide and protein research 1995;45(2):100-5.
1995: R Fattorusso; G Morelli; Angela Lombardi; Flavia Nastri; Ornella Maglio; G D'Auria; Carlo Pedone; Vincenzo Pavone
Design of metal ion binding peptides.
Biopolymers 1995;37(6):401-10.
1994: Vincenzo Pavone; Angela Lombardi; Michele Saviano; Benedetto Di Blasio; Flavia Nastri; R Fattorusso; L Zaccaro; Ornella Maglio; T Yamada; Y Omote
Mixed conformation in C alpha, alpha-disubstituted tripeptides: x-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe.
Biopolymers 1994;34(12):1595-604.
1994: Vincenzo Pavone; Angela Lombardi; Michele Saviano; Flavia Nastri; R Fattorusso; Ornella Maglio; C Isernia; Livio Paolillo; Carlo Pedone
Beta-alanine containing cyclic peptides with turned structure: the "pseudo type II beta-turn." VI.
Biopolymers 1994;34(11):1517-26.
1994: Vincenzo Pavone; Angela Lombardi; Michele Saviano; Benedetto Di Blasio; Flavia Nastri; R Fattorusso; Ornella Maglio; C Isernia
Beta-alanine containing cyclic peptides with predetermined turned structure. V.
Biopolymers 1994;34(11):1505-15.
1994: Benedetto Di Blasio; Michele Saviano; R Fattorusso; Angela Lombardi; Carlo Pedone; V Valle; G P Lorenzi
A crystal structure with features of an antiparallel alpha-pleated sheet.
Biopolymers 1994;34(11):1463-8.
1993: N Fabiano; G Valle; Marco Crisma; Claudio Toniolo; Michele Saviano; Angela Lombardi; C Isernia; Vincenzo Pavone; Benedetto Di Blasio; Carlo Pedone
Conformational versatility of the N alpha-acylated tripeptide amide tail of oxytocin. Synthesis and crystallographic characterization of three C2 alpha-backbone modified, conformationally restricted analogues.
International journal of peptide and protein research 1993;42(5):459-65.
1993: Benedetto Di Blasio; Vincenzo Pavone; Angela Lombardi; Carlo Pedone; Ettore Benedetti
Noncoded residues as building blocks in the design of specific secondary structures: symmetrically disubstituted glycines and beta-alanine.
Biopolymers 1993;33(7):1037-49.
1993: Benedetto Di Blasio; Angela Lombardi; G D'Auria; Michele Saviano; C Isernia; Ornella Maglio; Livio Paolillo; Carlo Pedone; Vincenzo Pavone
beta-Alanine containing peptides: gamma-turns in cyclotetrapeptides.
Biopolymers 1993;33(4):621-31.
1993: Vincenzo Pavone; Benedetto Di Blasio; Angela Lombardi; Ornella Maglio; C Isernia; Carlo Pedone; Ettore Benedetti; E Altmann; Manfred Mutter
Non coded C alpha, alpha-disubstituted amino acids. X-ray diffraction analysis of a dipeptide containing (S)-alpha-methylserine.
International journal of peptide and protein research 1993;41(1):15-20.
1992: Benedetto Di Blasio; Angela Lombardi; Flavia Nastri; Michele Saviano; Carlo Pedone; T Yamada; M Nakao; S Kuwata; Vincenzo Pavone
Conformation of diastereomeric peptide sequences: structural analysis of Z-D-Val-Ac6c-Gly-L-Phe-OMe.
Biopolymers 1992;32(9):1155-61.
1992: Vincenzo Pavone; Angela Lombardi; G D'Auria; Michele Saviano; Flavia Nastri; Livio Paolillo; Benedetto Di Blasio; Carlo Pedone
Beta-alanine containing peptides: a novel molecular tool for the design of gamma-turns.
Biopolymers 1992;32(2):173-83.
1991: Benedetto Di Blasio; Angela Lombardi; X Yang; Carlo Pedone; Vincenzo Pavone
beta-Alanyl-beta-alanine in cyclic beta-turned peptides.
Biopolymers 1991;31(10):1181-8.
1989: V Pavone; Ettore Benedetti; Benedetto Di Blasio; Angela Lombardi; Carlo Pedone; L Tomasich; G P Lorenzi
Regularly alternating L,D-peptides. III. Hexacyclic peptides from valine or phenylalanine.
Biopolymers 1989;28(1):215-23.