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Giovanna Lombardi

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Lesley A Smyth; Yakup Tanriver; Sally Alcock; Matthew Buckland; Robert Lechler; Lucy Meader; Aurelie Moreau; Kulachelvy Ratnasothy; Pervinder Sagoo; Giovanna Lombardi
Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs.
James B Canavan; Behdad Afzali; Graham M Lord; Giovanna Lombardi
Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy.
Pervinder Sagoo; Yuen Tsang; Linda D Barber; Robert I Lechler; Alistair Noble; Kulachelvy Ratnasothy; Giovanna Lombardi
Alloantigen-specific regulatory T cells prevent experimental chronic graft-versus-host disease by simultaneous control of allo- and autoreactivity.

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All Publications

2013: Lesley A Smyth; Yakup Tanriver; Sally Alcock; Matthew Buckland; Robert Lechler; Lucy Meader; Aurelie Moreau; Kulachelvy Ratnasothy; Pervinder Sagoo; Giovanna Lombardi
Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4848-60.
2013: James B Canavan; Behdad Afzali; Graham M Lord; Giovanna Lombardi
Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy.
Expert review of molecular diagnostics 2013;13(1):5-7.
2012: Pervinder Sagoo; Yuen Tsang; Linda D Barber; Robert I Lechler; Alistair Noble; Kulachelvy Ratnasothy; Giovanna Lombardi
Alloantigen-specific regulatory T cells prevent experimental chronic graft-versus-host disease by simultaneous control of allo- and autoreactivity.
European journal of immunology 2012;42(12):3322-33.
2012: Aurélie Moreau; Alistair Noble; Kulachelvy Ratnasothy; Elizabeth Simpson; Jian-Guo Chai; Maria Cristina Cuturi; Louise Deltour; Robert Lechler; Giovanna Lombardi
Absence of Galectin-1 accelerates CD8⁺ T cell-mediated graft rejection.
European journal of immunology 2012;42(11):2881-8.
2012: Lesley A Smyth; Robert I Lechler; Giovanna Lombardi; Pablo D Becker; Richard Ellis; Thomas Hayday; Catherine Hervouet; Linda S Klavinskis
Acquisition of MHC:peptide complexes by dendritic cells contributes to the generation of antiviral CD8+ T cell immunity in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2274-82.
2012: James B Canavan; Francis C Edozie; Henrieta Fazekasova; Maria P Hernandez-Fuentes; Giovanna Lombardi; Thomas T Macdonald; Cristiano Scottà; Behdad Afzali; Graham M Lord
A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.
Blood 2012;119(8):e57-66.
2012: Niwa Ali; Linda D Barber; Barry Flutter; Giovanna Lombardi; Robert Sanchez Rodriguez; Ehsan Sharif-Paghaleh; Frank O Nestle
Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotype.
PloS one 2012;7(8):e44219.
2012: Pervinder Sagoo; Giovanna Lombardi; Robert I Lechler
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation.
Frontiers in immunology 2012;3():184.
2012: Ke Li; Giovanna Lombardi; Qi Peng; Steven H Sacks; Naiyin Wang; Henrieta Fazekasova; Wuding Zhou
Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a.
Immunobiology 2012;217(1):65-73.
2011: Henrieta Fazekasova; Kelly Langford; Robert Lechler; Giovanna Lombardi
Placenta-derived MSCs are partially immunogenic and less immunomodulatory than bone marrow-derived MSCs.
Journal of tissue engineering and regenerative medicine 2011;5(9):684-94.
2011: Pervinder Sagoo; Niwa Ali; Garima Garg; Frank O Nestle; Robert I Lechler; Giovanna Lombardi
Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells.
Science translational medicine 2011;3(83):83ra42.
2011: Ke Li; Henrieta Fazekasova; Naiyin Wang; Pervinder Sagoo; Qi Peng; Wafa Khamri; Chantelle Gomes; Steven H Sacks; Giovanna Lombardi; Wuding Zhou
Expression of complement components, receptors and regulators by human dendritic cells.
Molecular immunology 2011;48(9-10):1121-7.
2011: Giovanna Lombardi; Pervinder Sagoo; Cristiano Scotta; Henrieta Fazekasova; Lesley Smyth; Julia Tsang; Behdad Afzali; Robert Lechler
Cell therapy to promote transplantation tolerance: a winning strategy?
Immunotherapy 2011;3(4 Suppl):28-31.
2011: Fabiana Paladini; Elisa Cocco; Ilaria Potolicchio; Henrieta Fazekasova; Giovanna Lombardi; Maria Teresa Fiorillo; Rosa Sorrentino
Divergent effect of cobalt and beryllium salts on the fate of peripheral blood monocytes and T lymphocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(2):257-69.
2011: Cees van Kooten; Giovanna Lombardi; Kyra A Gelderman; Pervinder Sagoo; Matthew Buckland; Robert Lechler; Maria Cristina Cuturi
Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities.
Transplantation 2011;91(1):2-7.
2011: Ehsan Sharif-Paghaleh; Lesley A Smyth; Kavitha Sunassee; Richard Tavaré; Rowa Alhabbab; Niwa Ali; Philip J Blower; Alexander Koers; Robert I Lechler; Gregory E Mullen; Kulachelvy Ratnasothy; Giovanna Lombardi
In vivo SPECT reporter gene imaging of regulatory T cells.
PloS one 2011;6(10):e25857.
2011: Richard Tavaré; Pervinder Sagoo; Gopal Varama; Yakup Tanriver; Alice Warely; Sandra S Diebold; Richard Southworth; Tobias Schaeffter; Robert I Lechler; Reza Razavi; Giovanna Lombardi; Gregory E D Mullen
Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination.
PloS one 2011;6(5):e19662.
2010: Niloufar Safinia; Behdad Afzali; Kerem Atalar; Giovanna Lombardi; Robert I Lechler
T-cell alloimmunity and chronic allograft dysfunction.
Kidney international. Supplement 2010;(119):S2-12.
2010: Niloufar Safinia; Pervinder Sagoo; Robert Lechler; Giovanna Lombardi
Adoptive regulatory T cell therapy: challenges in clinical transplantation.
Current opinion in organ transplantation 2010;15(4):427-34.
2010: Yakup Tanriver; Kulachelvy Ratnasothy; R Pat Bucy; Giovanna Lombardi; Robert Lechler
Targeting MHC class I monomers to dendritic cells inhibits the indirect pathway of allorecognition and the production of IgG alloantibodies leading to long-term allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1757-64.
2010: Wafa Khamri; Marjorie M Walker; Peter Clark; John C Atherton; Mark R Thursz; Kathleen B Bamford; Robert I Lechler; Giovanna Lombardi
Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes.
Infection and immunity 2010;78(2):845-53.
2009: Yakup Tanriver; Alfonso Martín-Fontecha; Kulachelvy Ratnasothy; Giovanna Lombardi; Robert Lechler
Superantigen-activated regulatory T cells inhibit the migration of innate immune cells and the differentiation of naive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):2946-56.
2009: Julia Yuen-Shan Tsang; Yakup Tanriver; Shuiping Jiang; Eva Leung; Kulachelvy Ratnasothy; Giovanna Lombardi; Robert Lechler
Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression.
Transplant immunology 2009;21(4):203-9.
2009: Peter Mitchell; Behdad Afzali; Giovanna Lombardi; Robert I Lechler
The T helper 17-regulatory T cell axis in transplant rejection and tolerance.
Current opinion in organ transplantation 2009;14(4):326-31.
2009: Henrieta Fazekasova; Dela Golshayan; Joseph Read; Aristotle Tsallios; Julia Yuen-Shan Tsang; Anthony Dorling; Andrew J T George; Robert I Lechler; Giovanna Lombardi; Vincenzo Mirenda
Regulation of rat and human T-cell immune response by pharmacologically modified dendritic cells.
Transplantation 2009;87(11):1617-28.
2009: Shahram Kordasti; Behdad Afzali; Ziyi Lim; Wendy Ingram; Janet Hayden; Linda Barber; Katie Matthews; Rajani Chelliah; Barbara Guinn; Giovanna Lombardi; Farzin Farzaneh; Ghulam J Mufti
IL-17-producing CD4(+) T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome.
British journal of haematology 2009;145(1):64-72.
2009: Kerem Atalar; Behdad Afzali; Graham Lord; Giovanna Lombardi
Relative roles of Th1 and Th17 effector cells in allograft rejection.
Current opinion in organ transplantation 2009;14(1):23-9.
2008: Pervinder Sagoo; Giovanna Lombardi; Robert I Lechler
Regulatory T cells as therapeutic cells.
Current opinion in organ transplantation 2008;13(6):645-53.
2008: Julia Yuen-Shan Tsang; Yakup Tanriver; Shuiping Jiang; Shao-An Xue; Kulachelvy Ratnasothy; Daxin Chen; Hans J Stauss; R Pat Bucy; Giovanna Lombardi; Robert Lechler
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.
The Journal of clinical investigation 2008;118(11):3619-28.
2008: Lesley Ann Smyth; Nicola Harker; Wayne Turnbull; Haytham El-Doueik; Linda Klavinskis; Dimitris Kioussis; Giovanna Lombardi; Robert Lechler
The relative efficiency of acquisition of MHC:peptide complexes and cross-presentation depends on dendritic cell type.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3212-20.
2008: Behdad Afzali; Giovanna Lombardi; Robert I Lechler
Pathways of major histocompatibility complex allorecognition.
Current opinion in organ transplantation 2008;13(4):438-44.
2007: Shahram Kordasti; Wendy Ingram; Janet Hayden; David Darling; Linda Barber; Behdad Afzali; Giovanna Lombardi; Marcin W Wlodarski; Jaroslaw P Maciejewski; Farzin Farzaneh; Ghulam J Mufti
CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS).
Blood 2007;110(3):847-50.
2007: John Yates; Flavia Rovis; Peter Mitchell; Behdad Afzali; Julia Y S Tsang; Marina Garin; Robert I Lechler; Giovanna Lombardi; Oliver A Garden
The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro.
International immunology 2007;19(6):785-99.
2007: L A Smyth; Behdad Afzali; Julia Tsang; Giovanna Lombardi; Robert I Lechler
Intercellular transfer of MHC and immunological molecules: molecular mechanisms and biological significance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(6):1442-9.
2007: George Avraamides; Chi-Yan Ng; Rachel David; Yan Gu; Henrieta Fazekasova; Vincenzo Mirenda; Graham R Foster; Laura Runkel; Giovanna Lombardi; Federica M Marelli-Berg
IFN-alpha2 induces leukocyte integrin redistribution, increased adhesion, and migration.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(4):291-303.
2007: Behdad Afzali; Giovanna Lombardi; Robert I Lechler; Graham M Lord
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease.
Clinical and experimental immunology 2007;148(1):32-46.
2007: Peter Mitchell; Conrad Germain; Pier Luigi Fiori; Wafa Khamri; Graham R Foster; Subrata Ghosh; Robert I Lechler; Kathleen B Bamford; Giovanna Lombardi
Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development.
Infection and immunity 2007;75(2):810-9.
2007: Rajesh Ramasamy; Henrietta Fazekasova; Eric W-F Lam; Inês Soeiro; Giovanna Lombardi; Francesco Dazzi
Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle.
Transplantation 2007;83(1):71-6.
2006: Shuiping Jiang; Julia Tsang; David S Game; Saskia Stevenson; Giovanna Lombardi; Robert I Lechler
Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation tolerance.
Transplantation 2006;82(12):1738-43.
2006: Matthew Buckland; Charlotte Jago; Henrieta Fazekesova; Andrew George; Robert Lechler; Giovanna Lombardi
Aspirin modified dendritic cells are potent inducers of allo-specific regulatory T-cells.
International immunopharmacology 2006;6(13-14):1895-901.
2006: Julia Tsang; Shuiping Jiang; Yakup Tanriver; Eva Leung; Giovanna Lombardi; Robert I Lechler
In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity.
International immunopharmacology 2006;6(13-14):1883-8.
2006: Shuiping Jiang; Dela Golshayan; Julia Tsang; Giovanna Lombardi; Robert I Lechler
In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance.
International immunopharmacology 2006;6(13-14):1879-82.
2006: M Buckland; C B Jago; Henrieta Fazekasova; K Scott; Peng H Tan; Andrew J T George; R Lechler; Giovanna Lombardi
Aspirin-treated human DCs up-regulate ILT-3 and induce hyporesponsiveness and regulatory activity in responder T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(9):2046-59.
2006: Lesley Ann Smyth; Osquel Barroso Herrera; Dela Golshayan; Giovanna Lombardi; Robert I Lechler
A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases.
Transplantation 2006;82(1 Suppl):S15-8.
2006: Julia Y S Tsang; niels camara; Efrem Eren; Helga Schneider; Christopher Rudd; Giovanna Lombardi; Robert Lechler
Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells.
Journal of leukocyte biology 2006;80(1):145-51.
2006: Shuiping Jiang; Robert I Lechler; Giovanna Lombardi
CD4+CD25+ regulatory T-cell therapy.
Expert review of clinical immunology 2006;2(3):387-92.
2006: Matt Butler; Chi-Yan Ng; David A van Heel; Giovanna Lombardi; Robert Lechler; Raymond J Playford; Subrata Ghosh
Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium.
European journal of immunology 2006;36(4):864-74.
2006: Anna Maria Malfitano; Rachel Cahill; Peter Mitchell; Gad Frankel; Gordon Dougan; Maurizio Bifulco; Giovanna Lombardi; Robert I Lechler; Kathleen B Bamford
Helicobacter pylori has stimulatory effects on naive T cells.
Helicobacter 2006;11(1):21-30.
2006: Efrem Eren; J Yates; Kate Cwynarski; S Preston; R Dong; C Germain; Robert Lechler; R Huby; M Ritter; Giovanna Lombardi
Location of major histocompatibility complex class II molecules in rafts on dendritic cells enhances the efficiency of T-cell activation and proliferation.
Scandinavian journal of immunology 2006;63(1):7-16.
2005: A Tamir; William J Jordan; M Ritter; N Habib; Robert I Lechler; Graham R Foster; Giovanna Lombardi
Interferon-alpha2a is sufficient for promoting dendritic cell immunogenicity.
Clinical and experimental immunology 2005;142(3):471-80.
2005: Leo M Carlin; Kumiko Yanagi; Adrienne Verhoef; Esther N M Nolte-'t Hoen; John Yates; Leanne Gardner; Jonathan Lamb; Giovanna Lombardi; Margaret J Dallman; Daniel M Davis
Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse.
Blood 2005;106(12):3874-9.
2005: Peng H Tan; John B Yates; Shao-An Xue; Cliburn Chan; William J Jordan; Jennifer E Harper; Martin P Watson; Rong Dong; Mary A Ritter; Robert I Lechler; Giovanna Lombardi; Andrew J T George
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.
Blood 2005;106(9):2936-43.
2005: Nicola J Rogers; David S Game; Niels O S Camara; Ian M Jackson; Giovanna Lombardi; Robert I Lechler
Distinct effects of CD86-mediated costimulation on resting versus activated human CD4+ T cells.
European journal of immunology 2005;35(10):2909-19.
2005: Karen Scott; Maria Manunta; Conrad Germain; Peter Smith; Meleri Jones; Peter Mitchell; Daniele Dessi; Kathleen Branigan Bamford; Robert I Lechler; Pier Luigi Fiori; Graham R Foster; Giovanna Lombardi
Qualitatively distinct patterns of cytokines are released by human dendritic cells in response to different pathogens.
Immunology 2005;116(2):245-54.
2005: Peng H Tan; Pervinder Sagoo; Cliburn Chan; John B Yates; Jamie Campbell; Sven Christoph Beutelspacher; Brian M J Foxwell; Giovanna Lombardi; Andrew J T George
Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7633-44.
2005: Peng H Tan; Sven Christoph Beutelspacher; Yao-He Wang; Myra O McClure; Mary A Ritter; Giovanna Lombardi; Andrew J T George
Immunolipoplexes: an efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):790-800.
2005: Shuiping Jiang; David S Game; Derek Davies; Giovanna Lombardi; Robert I Lechler
Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4+CD25+ regulatory T cells?
European journal of immunology 2005;35(4):1193-200.
2004: Graham R Foster; Siti H Masri; Rachel David; Meleri Jones; Arpita Datta; Giovanna Lombardi; Laura Runkell; Carole de Dios; Irene Sizing; Martha J James; Federica M Marelli-Berg
IFN-alpha subtypes differentially affect human T cell motility.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1663-70.
2004: Kate Cwynarski; Ruthline Laylor; E Macchiarulo; J Goldman; Giovanna Lombardi; Junia V Melo; Francesco Dazzi
Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro.
Leukemia 2004;18(8):1332-9.
2004: C B Jago; John Yates; N Olsen Saraiva Câmara; Robert I Lechler; Giovanna Lombardi
Differential expression of CTLA-4 among T cell subsets.
Clinical and experimental immunology 2004;136(3):463-71.
2003: Martha J James; Lavina L Belaramani; Kanella Prodromidou; Arpita Datta; Sussan Nourshargh; Giovanna Lombardi; Julian Dyson; Diane Scott; Elizabeth Simpson; Lorraine Cardozo; Anthony N Warrens; Richard Szydlo; Robert I Lechler; Federica M Marelli-Berg
Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism.
Blood 2003;102(6):2173-9.
2003: Rong Dong; Kate Cwynarski; Alan Entwistle; Federica M Marelli-Berg; Francesco Dazzi; Elizabeth Simpson; John M Goldman; Junia V Melo; Robert I Lechler; Ilaria Bellantuono; Anne Ridley; Giovanna Lombardi
Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration.
Blood 2003;101(9):3560-7.
2003: Nicola J Rogers; Ian M Jackson; William James Jordan; Giovanna Lombardi; Alexandros Delikouras; Robert I Lechler
CD40 can costimulate human memory T cells and favors IL-10 secretion.
European journal of immunology 2003;33(4):1094-104.
2001: W F Ng; P J Duggan; Frederique Ponchel; G Matarese; Giovanna Lombardi; A D Edwards; John D Isaacs; Robert I Lechler
Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.
Blood 2001;98(9):2736-44.
2001: WF Ng; Maria P Hernandez-Fuentes; Giovanna Lombardi
Predictive value of in vitro assessment of direct alloresponses in transplant recipients?
Transplantation 2001;72(5):772-3.
2001: Robert Lechler; Jian-Guo Chai; Federica M Marelli-Berg; Giovanna Lombardi
The contributions of T-cell anergy to peripheral T-cell tolerance.
Immunology 2001;103(3):262-9.
2001: Robert Lechler; Jian-Guo Chai; Federica M Marelli-Berg; Giovanna Lombardi
T-cell anergy and peripheral T-cell tolerance.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):625-37.
2001: Giovanna Lombardi; C Germain; J Uren; Maria Teresa Fiorillo; R M du Bois; W Jones-Williams; Cesare Saltini; Rosa Sorrentino; Robert Lechler
HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3549-55.
2001: Federica M Marelli-Berg; M Alvarez-Iglesias; Kanella Prodromidou; Giovanna Lombardi; L Frasca; L P Berg; Robert I Lechler
T cell receptor engagement can influence T cell motility.
Transplantation proceedings 2001;33(1-2):312-3.
2001: R Lindstedt; NJ Monk; Giovanna Lombardi; Robert Lechler
Amino acid substitutions in the putative MHC class II "dimer of dimers" interface inhibit CD4+ T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):800-8.
2000: Graham R Foster; Conrad Germain; Meleri Jones; Robert I Lechler; Giovanna Lombardi
Human T cells elicit IFN-alpha secretion from dendritic cells following cell to cell interactions.
European journal of immunology 2000;30(11):3228-35.
2000: S Vendetti; Jian-Guo Chai; Julian Dyson; Elizabeth Simpson; Giovanna Lombardi; Robert Lechler
Anergic T cells inhibit the antigen-presenting function of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1175-81.
2000: Philip Hornick; PD Mason; RJ Baker; Maria P Hernandez-Fuentes; L Frasca; Giovanna Lombardi; K Taylor; L Weng; ML Rose; MH Yacoub; R Batchelor; Robert I Lechler
Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection.
Circulation 2000;101(20):2405-10.
1999: Federica M Marelli-Berg; L Frasca; Nesrina Imami; Giovanna Lombardi; Robert I Lechler
Lack of T cell proliferation without induction of nonresponsiveness after antigen presentation by endothelial cells.
Transplantation 1999;68(2):280-7.
1999: Federica M Marelli-Berg; L Frasca; L Weng; Giovanna Lombardi; Robert I Lechler
Antigen recognition influences transendothelial migration of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):696-703.
1998: L Frasca; A Amendola; Philip Hornick; Paul A Brookes; G Aichinger; Federica M Marelli-Berg; Robert I Lechler; Giovanna Lombardi
Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity.
Transplantation 1998;66(9):1238-43.
1998: L Frasca; Federica M Marelli-Berg; Nesrina Imami; I Potolicchio; P Carmichael; Giovanna Lombardi; Robert Lechler
Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance.
Kidney international 1998;53(3):679-89.
1997: Federica M Marelli-Berg; A Weetman; L Frasca; S J Deacock; Nesrina Imami; Giovanna Lombardi; Robert I Lechler
Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5853-61.
1997: L Frasca; P Carmichael; Robert Lechler; Giovanna Lombardi
Anergic T cells effect linked suppression.
European journal of immunology 1997;27(12):3191-7.
1997: R G Hargreaves; NJ Borthwick; MS Gilardini Montani; Enza Piccolella; P Carmichael; Robert I Lechler; Arne N Akbar; Giovanna Lombardi
Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3099-107.
1997: R G Hargreaves; NJ Borthwick; MS Gilardini Montani; M S Montani; Enza Piccolella; P Carmichael; Robert I Lechler; Arne N Akbar; Giovanna Lombardi
Induction of apoptosis following antigen presentation by T cells: anergy and apoptosis are two separate phenomena.
Transplantation proceedings 1997;29(1-2):1102-4.
1997: Giovanna Lombardi; K Arnold; J Uren; Federica M Marelli-Berg; R Hargreaves; Nesrina Imami; A Weetman; Robert Lechler
Antigen presentation by interferon-gamma-treated thyroid follicular cells inhibits interleukin-2 (IL-2) and supports IL-4 production by B7-dependent human T cells.
European journal of immunology 1997;27(1):62-71.
1996: P Carmichael; L A Kerr; A Kelly; Giovanna Lombardi; B U Zeigler; A Ziegler; J Trowsdale; Robert Lechler
The TAP complex influences allorecognition of class II MHC molecules.
Human immunology 1996;50(1):70-7.
1996: Anthony Dorling; Giovanna Lombardi; R Binns; Robert I Lechler
Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population.
European journal of immunology 1996;26(6):1378-87.
1996: Giovanna Lombardi; R Hargreaves; S Sidhu; Nesrina Imami; L Lightstone; S Fuller-Espie; M Ritter; P Robinson; Attila Tarnok; Robert Lechler
Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2769-75.
1996: Federica M Marelli-Berg; R E Hargreaves; P Carmichael; Anthony Dorling; Giovanna Lombardi; Robert I Lechler
Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells.
The Journal of experimental medicine 1996;183(4):1603-12.
1995: R E Hargreaves; R D Brehm; Howard S Tranter; Anthony N Warrens; Giovanna Lombardi; Robert I Lechler
Definition of sites on HLA-DR1 involved in the T cell response to staphylococcal enterotoxins E and C2.
European journal of immunology 1995;25(12):3437-44.
1995: Loretta Tuosto; C Piazza; S Moretti; Andrea Modesti; R Greenlaw; Robert Lechler; Giovanna Lombardi; Enza Piccolella
Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.
European journal of immunology 1995;25(10):2917-22.
1995: Loretta Tuosto; MS Gilardini Montani; S Lorenzetti; Enrico Cundari; S Moretti; Giovanna Lombardi; Enza Piccolella
Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations.
European journal of immunology 1995;25(10):2907-16.
1995: C J Derry; C N Ross; Giovanna Lombardi; PD Mason; A J Rees; Robert I Lechler; Charles D Pusey
Analysis of T cell responses to the autoantigen in Goodpasture's disease.
Clinical and experimental immunology 1995;100(2):262-8.
1995: Giovanna Lombardi; Anthony N Warrens; Robert I Lechler
Anergic T cells act as suppressor cells in vitro.
Transplantation proceedings 1995;27(1):235-6.
1994: A George; F Dazzi; J Lynch; S Sidhu; F Marelli; R J Batchelor; Giovanna Lombardi; Robert I Lechler
Biased TCR gene usage in alloreactive T cells specific for a structurally dissimilar MHC alloantigen.
International immunology 1994;6(11):1785-90.
1994: Loretta Tuosto; R W Karr; X T Fu; R R Olson; Enrico Cundari; Enza Piccolella; Robert Lechler; Giovanna Lombardi
Different regions of the N-terminal domains of HLA-DR1 influence recognition of individual peptide-DR1 complexes.
Human immunology 1994;40(4):312-22.
1994: A I Dodi; S Brett; Tommy W Nordeng; S Sidhu; R J Batchelor; Giovanna Lombardi; Oddmund Bakke; Robert I Lechler
The invariant chain inhibits presentation of endogenous antigens by a human fibroblast cell line.
European journal of immunology 1994;24(7):1632-9.
1994: Giovanna Lombardi; S Sidhu; R Batchelor; Robert Lechler
Anergic T cells as suppressor cells in vitro.
Science (New York, N.Y.) 1994;264(5165):1587-9.
1994: Anthony N Warrens; Giovanna Lombardi; Robert I Lechler
Presentation and recognition of major and minor histocompatibility antigens.
Transplant immunology 1994;2(2):103-7.
1994: Anthony N Warrens; J Y Zhang; S Sidhu; D J Watt; Giovanna Lombardi; C A Sewry; Robert I Lechler
Myoblasts fail to stimulate T cells but induce tolerance.
International immunology 1994;6(6):847-53.
1994: Giovanna Lombardi; S Sidhu; T Dodi; R Batchelor; Robert Lechler
Failure of correlation between B7 expression and activation of interleukin-2-secreting T cells.
European journal of immunology 1994;24(3):523-30.
1994: Anthony N Warrens; T Heaton; S Sidhu; Giovanna Lombardi; Robert I Lechler
Transfected murine cells expressing HLA class II can be used to generate alloreactive human T cell clones.
Journal of immunological methods 1994;169(1):25-33.
1992: S Sidhu; S Deacock; V Bal; J R Batchelor; Giovanna Lombardi; Robert I Lechler
Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells.
The Journal of experimental medicine 1992;176(3):875-80.
1992: Robert I Lechler; T Heaton; L Barber; V Bal; J R Batchelor; Giovanna Lombardi
Molecular mimicry by major histocompatibility complex molecules and peptides accounts for some alloresponses.
Immunology letters 1992;34(1):63-9.
1992: R Greenlaw; P Robinson; T Heaton; Giovanna Lombardi; Robert Lechler
Transfection of HLA-DR-expressing DAP.3 cells with a cDNA clone encoding the glycosyl phosphatidylinositol-linked form of lymphocyte function associated antigen-3: biochemical features and functional consequences.
International immunology 1992;4(6):673-80.
1991: AD Rees; Y Donati; Giovanna Lombardi; J Lamb; Barbara S Polla; Robert Lechler
Stress-induced modulation of antigen-presenting cell function.
Immunology 1991;74(3):386-92.
1991: Giovanna Lombardi; L Barber; G Aichinger; T Heaton; S Sidhu; J R Batchelor; Robert I Lechler
Structural analysis of anti-DR1 allorecognition by using DR1/H-2Ek hybrid molecules. Influence of the beta 2-domain correlates with CD4 dependence.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):2034-40.
1991: Giovanna Lombardi; L Barber; S Sidhu; J R Batchelor; Robert I Lechler
The specificity of alloreactive T cells is determined by MHC polymorphisms which contact the T cell receptor and which influence peptide binding.
International immunology 1991;3(8):769-75.
1991: PD Mason; Giovanna Lombardi; Robert I Lechler
NK cells inhibit T-cell responses: LFA3+ but not LFA3- T-cell responses are suppressed.
Immunology 1991;73(4):444-9.
1991: Robert Lechler; R Batchelor; Giovanna Lombardi
The relationship between MHC restricted and allospecific T cell recognition.
Immunology letters 1991;29(1-2):41-50.
1991: C G Mackworth-Young; M Kevany; Giovanna Lombardi; S Sidhu; C Sharrock; J R Batchelor; Robert I Lechler
A monoclonal antibody with broad anti-HLA-DR activity fails to bind to DRw11/Dw5: possible effect of a unique polymorphism on the beta 1 domain alpha-helix.
Human immunology 1991;30(3):174-82.
1991: Giovanna Lombardi; M Matsui; R Moots; G Aichinger; S Sidhu; R Batchelor; A J McMichael; Jeffrey Frelinger; Robert Lechler
Structural relationship between HLA-A2-restricted and anti-A2 allospecific T-cell recognition: analysis by mutation of the codons for polymorphic and conserved residues.
Transplantation proceedings 1991;23(1 Pt 1):446-8.
1991: D Palmer; M Kevany; C Mackworth-Young; R Batchelor; Giovanna Lombardi; Robert Lechler
Generation and characterization of an HLA-DR alpha-specific monoclonal antibody using L-cell transfectants expressing human and mouse class II major histocompatibility dimers.
Immunogenetics 1991;33(1):12-7.
1991: Giovanna Lombardi; Robert Lechler
The molecular basis of allorecognition of major histocompatibility complex molecules by T lymphocytes.
Annali dell'Istituto superiore di sanità 1991;27(1):7-14.
1991: Giovanna Lombardi; M Matsui; R Moots; G Aichinger; S Sidhu; R Batchelor; Jeffrey Frelinger; Robert Lechler
Limited regions of the alpha 2-domain alpha-helix control anti-A2 allorecognition: an analysis using a panel of A2 mutants.
Immunogenetics 1991;34(3):149-56.
1990: V Bal; A McIndoe; G Denton; D Hudson; Giovanna Lombardi; J Lamb; Robert Lechler
Antigen presentation by keratinocytes induces tolerance in human T cells.
European journal of immunology 1990;20(9):1893-7.
1990: J R Batchelor; E Kaminski; Giovanna Lombardi; John M Goldman; Robert I Lechler
Individual variation in alloresponsiveness and the molecular basis of allorecognition.
Human immunology 1990;28(2):96-103.
1990: Robert I Lechler; Giovanna Lombardi; J R Batchelor; N Reinsmoen; F H Bach
The molecular basis of alloreactivity.
Immunology today 1990;11(3):83-8.
1990: Robert Lechler; Giovanna Lombardi
The structural basis of alloreactivity.
Immunologic research 1990;9(2):135-46.
1990: Giovanna Lombardi; S Sidhu; M Daly; J R Batchelor; W Makgoba; Robert I Lechler
Are primary alloresponses truly primary?
International immunology 1990;2(1):9-13.
1990: MS Gilardini Montani; F Del Gallo; marco gobbi; Giovanna Lombardi; Enza Piccolella; Orsola Pugliese; Vittorio Colizzi
Regulation of self-major histocompatibility complex reactive human T-cell clones.
International journal of immunopharmacology 1990;12(3):255-60.
1990: F Del Gallo; Giovanna Lombardi; Enza Piccolella; MS Gilardini Montani; Paola Del Porto; Orsola Pugliese; G Antonelli; Vittorio Colizzi
Increased autoreactive T cell frequency in tuberculous patients.
International archives of allergy and applied immunology 1990;91(1):36-42.
1990: D Vismara; M F Mezzopreti; MS Gilardini Montani; M S Gilardini; Paola Del Porto; Giovanna Lombardi; Enza Piccolella; G Damiani; R Rappuoli; Vittorio Colizzi
Identification of a 35-kilodalton Mycobacterium tuberculosis protein containing B- and T-cell epitopes.
Infection and immunity 1990;58(1):245-51.
1989: Giovanna Lombardi; S Sidhu; J R Batchelor; Robert I Lechler
Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4190-4.
1989: PD Mason; Giovanna Lombardi; J G Patrick Sissons; Leszek K Borysiewicz; Robert I Lechler
Target specificity of immunoregulation by natural killer cells.
Transplantation proceedings 1989;21(1 Pt 1):201-2.
1989: Giovanna Lombardi; S Sidhu; Jonathan R Lamb; J R Batchelor; Robert I Lechler
Endogenous peptides contribute to the ligand recognized by anti-DR1 human alloreactive T cells.
Transplantation proceedings 1989;21(1 Pt 1):142-4.
1989: Giovanna Lombardi; S Sidhu; Jonathan R Lamb; J R Batchelor; Robert I Lechler
Co-recognition of endogenous antigens with HLA-DR1 by alloreactive human T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):753-9.
1989: MS Gilardini Montani; F Del Gallo; Giovanna Lombardi; Paola Del Porto; Enza Piccolella; F Arienzo; Vittorio Colizzi
Limiting dilution analysis of T cell unresponsiveness to mycobacteria in advanced disseminated tuberculosis.
Medical microbiology and immunology 1989;178(5):235-44.
1989: AD Rees; Giovanna Lombardi; A Scoging; L Barber; D Mitchell; J Lamb; Robert Lechler
Functional evidence for the recognition of endogenous peptides by autoreactive T cell clones.
International immunology 1989;1(6):624-30.
1989: Vittorio Colizzi; D Vismara; C D'Urso; M F Mezzopreti; Giovanna Lombardi; Enza Piccolella; G Damiani; P Marelli; Mario Campa
Analysis of Mycobacterium tuberculosis genoma and production of a recombinant protein containing specific B and T cell antigenic determinants--new approaches to second generation antituberculosis vaccines.
Zeitschrift für Erkrankungen der Atmungsorgane 1989;172(1):40-52.
1988: Enza Piccolella; Giovanna Lombardi; M Gobbi; M S Gilardini; Paola Del Porto; A Dolei; D Fioravanti; S Cochi; E Manella; Vittorio Colizzi
Induction and regulation of cytotoxic T cells by microbial antigens and recombinant interleukin 2.
Folia biologica 1988;34(5):316-29.
1987: Giovanna Lombardi; F del Gallo; D Vismara; Enza Piccolella; C de Martino; Carlo Garzelli; C Puglisi; Vittorio Colizzi
Epstein-Barr virus-transformed B cells process and present Mycobacterium tuberculosis particulate antigens to T-cell clones.
Cellular immunology 1987;107(2):281-92.
1986: Enza Piccolella; A Dolei; Giovanna Lombardi; D Vismara; P Pizzoli; Vittorio Colizzi; Ferdinando Dianzani
Regulation of immune interferon production during the response to soluble microbial antigens.
Clinical and experimental immunology 1986;65(1):190-7.
1986: Giovanna Lombardi; A M Di Massimo; F Del Gallo; D Vismara; Enza Piccolella; Orsola Pugliese; Vittorio Colizzi
Mechanism of action of an antigen nonspecific inhibitory factor produced by human T cells stimulated by MPPS and PPD.
Cellular immunology 1986;98(2):434-43.
1986: Enza Piccolella; Giovanna Lombardi; D Vismara; F Del Gallo; Vittorio Colizzi; A Dolei; Ferdinando Dianzani
Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens.
Infection and immunity 1986;51(2):712-4.
1985: Giovanna Lombardi; Enza Piccolella; D Vismara; Vittorio Colizzi; M Zembala
Monocyte subsets in the production of inhibitory factor by Candida albicans-activated human T cells.
Immunology 1985;56(2):373-6.
1985: D Vismara; Giovanna Lombardi; Enza Piccolella; Vittorio Colizzi
Dissociation between interleukin-1 and interleukin-2 production in proliferative response to microbial antigens: restorative effect of exogenous interleukin-2.
Infection and immunity 1985;49(2):298-304.
1985: Giovanna Lombardi; D Vismara; Enza Piccolella; Vittorio Colizzi; G L Asherson
A non-specific inhibitor produced by Candida albicans activated T cells impairs cell proliferation by inhibiting interleukin-1 production.
Clinical and experimental immunology 1985;60(2):303-10.
1985: Enza Piccolella; D Vismara; Giovanna Lombardi; D Guerritore; M Piantelli; F O Ranelletti
Effect of glucocorticoids on the development of suppressive activity in human lymphocyte response to a polysaccharide purified from Candida albicans.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(2):1166-71.
1984: Giovanna Lombardi; Enza Piccolella; D Vismara; Vittorio Colizzi; G L Asherson
Candida albicans polysaccharide extract (MPPS) and PPD stimulate the production of interleukin-1 and lymphocyte proliferation.
Clinical and experimental immunology 1984;58(3):581-6.