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Vincenzo Lombardi

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S Park-Holohan; Massimo Reconditi; Timothy G West; Roger C Woledge; Elisabetta Brunello; Nancy A Curtin; M Dolfi; Luca Fusi; Malcolm Irving; Marco Linari; Vincenzo Lombardi; Gabriella Piazzesi
Mechanics of myosin function in white muscle fibres of the dogfish, Scyliorhinus canicula.
R Elangovan; Vincenzo Lombardi; L Melli; Francesco S Pavone; Marco Capitanio; Gabriella Piazzesi
An integrated in vitro and in situ study of kinetics of myosin II from frog skeletal muscle.
Pasquale Bianco; Lorenzo Bongini; Mario Dolfi; Luca Melli; Vincenzo Lombardi
PicoNewton-millisecond force steps reveal the transition kinetics and mechanism of the double-stranded DNA elongation.

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All Publications

2012: S Park-Holohan; Massimo Reconditi; Timothy G West; Roger C Woledge; Elisabetta Brunello; Nancy A Curtin; M Dolfi; Luca Fusi; Malcolm Irving; Marco Linari; Vincenzo Lombardi; Gabriella Piazzesi
Mechanics of myosin function in white muscle fibres of the dogfish, Scyliorhinus canicula.
The Journal of physiology 2012;590(Pt 8):1973-88.
2012: R Elangovan; Vincenzo Lombardi; L Melli; Francesco S Pavone; Marco Capitanio; Gabriella Piazzesi
An integrated in vitro and in situ study of kinetics of myosin II from frog skeletal muscle.
The Journal of physiology 2012;590(Pt 5):1227-42.
2011: Pasquale Bianco; Lorenzo Bongini; Mario Dolfi; Luca Melli; Vincenzo Lombardi
PicoNewton-millisecond force steps reveal the transition kinetics and mechanism of the double-stranded DNA elongation.
Biophysical journal 2011;101(4):866-74.
2011: Marco Caremani; Steve Lehman; Vincenzo Lombardi; Marco Linari
Orthovanadate and orthophosphate inhibit muscle force via two different pathways of the myosin ATPase cycle.
Biophysical journal 2011;100(3):665-74.
2010: V Nucciotti; Chiara Stringari; Leonardo Sacconi; Francesco Vanzi; L Fusi; Marco Linari; Gabriella Piazzesi; Vincenzo Lombardi; Francesco S Pavone
Probing myosin structural conformation in vivo by second-harmonic generation microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(17):7763-8.
2010: Luca Fusi; Massimo Reconditi; Marco Linari; Elisabetta Brunello; Ravikrishnan Elangovan; Vincenzo Lombardi; Gabriella Piazzesi
The mechanism of the resistance to stretch of isometrically contracting single muscle fibres.
The Journal of physiology 2010;588(Pt 3):495-510.
2010: Marco Linari; Marco Caremani; Vincenzo Lombardi
A kinetic model that explains the effect of inorganic phosphate on the mechanics and energetics of isometric contraction of fast skeletal muscle.
Proceedings. Biological sciences / The Royal Society 2010;277(1678):19-27.
2009: E Brunello; L Fusi; Massimo Reconditi; Marco Linari; P Bianco; P Panine; Theyencheri Narayanan; Gabriella Piazzesi; Vincenzo Lombardi; Malcolm Irving
Structural changes in myosin motors and filaments during relaxation of skeletal muscle.
The Journal of physiology 2009;587(Pt 18):4509-21.
2009: Marco Linari; Gabriella Piazzesi; Vincenzo Lombardi
The effect of myofilament compliance on kinetics of force generation by myosin motors in muscle.
Biophysical journal 2009;96(2):583-92.
2007: Elisabetta Brunello; Massimo Reconditi; Ravikrishnan Elangovan; Marco Linari; Yin-Biao Sun; Theyencheri Narayanan; Pierre Panine; Gabriella Piazzesi; Malcolm Irving; Vincenzo Lombardi
Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):20114-9.
2007: Gabriella Piazzesi; Massimo Reconditi; Marco Linari; Leonardo Lucii; Pasquale Bianco; Elisabetta Brunello; Valérie Decostre; Alex Stewart; David B Gore; Thomas C Irving; Malcolm Irving; Vincenzo Lombardi
Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size.
Cell 2007;131(4):784-95.
2007: Marco Linari; Marco Caremani; Claudia Piperio; Philip Brandt; Vincenzo Lombardi
Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoas.
Biophysical journal 2007;92(7):2476-90.
2006: Elisabetta Brunello; P Bianco; Gabriella Piazzesi; Marco Linari; Massimo Reconditi; Pierre Panine; Theyencheri Narayanan; William I Helsby; Malcolm Irving; Vincenzo Lombardi
Structural changes in the myosin filament and cross-bridges during active force development in single intact frog muscle fibres: stiffness and X-ray diffraction measurements.
The Journal of physiology 2006;577(Pt 3):971-84.
2006: Marco Capitanio; Monica Canepari; P Cacciafesta; Vincenzo Lombardi; R Cicchi; M Maffei; Francesco S Pavone; Roberto Bottinelli
Two independent mechanical events in the interaction cycle of skeletal muscle myosin with actin.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):87-92.
2006: Francesco Vanzi; Marco Capitanio; Leonardo Sacconi; Chiara Stringari; R Cicchi; Monica Canepari; M Maffei; Nicoletta Piroddi; Corrado Poggesi; V Nucciotti; Marco Linari; Gabriella Piazzesi; Chiara Tesi; Renzo Antolini; Vincenzo Lombardi; Roberto Bottinelli; Francesco S Pavone
New techniques in linear and non-linear laser optics in muscle research.
Journal of muscle research and cell motility 2006;27(5-7):469-79.
2005: Valérie Decostre; P Bianco; Vincenzo Lombardi; Gabriella Piazzesi
Effect of temperature on the working stroke of muscle myosin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13927-32.
2005: Marco Linari; Elisabetta Brunello; Massimo Reconditi; Yin-Biao Sun; Pierre Panine; Theyencheri Narayanan; Gabriella Piazzesi; Vincenzo Lombardi; Malcolm Irving
The structural basis of the increase in isometric force production with temperature in frog skeletal muscle.
The Journal of physiology 2005;567(Pt 2):459-69.
2005: Massimo Reconditi; Marco Linari; Leonardo Lucii; Alex Stewart; Yin-Biao Sun; Theyencheri Narayanan; Thomas C Irving; Gabriella Piazzesi; Malcolm Irving; Vincenzo Lombardi
Structure-function relation of the myosin motor in striated muscle.
Annals of the New York Academy of Sciences 2005;1047():232-47.
2004: Vincenzo Lombardi; Gabriella Piazzesi; Massimo Reconditi; Marco Linari; Leonardo Lucii; Alex Stewart; Yin-Biao Sun; Peter Boesecke; Theyencheri Narayanan; Thomas C Irving; Malcolm Irving
X-ray diffraction studies of the contractile mechanism in single muscle fibres.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1452):1883-93.
2004: Marco Linari; Michael K Reedy; Mary C Reedy; Vincenzo Lombardi; Gabriella Piazzesi
Ca-activation and stretch-activation in insect flight muscle.
Biophysical journal 2004;87(2):1101-11.
2004: Massimo Reconditi; Marco Linari; Leonardo Lucii; Alex Stewart; Yin-Biao Sun; Peter Boesecke; Theyencheri Narayanan; Robert F Fischetti; Thomas C Irving; Gabriella Piazzesi; Malcolm Irving; Vincenzo Lombardi
The myosin motor in muscle generates a smaller and slower working stroke at higher load.
Nature 2004;428(6982):578-81.
2004: Marco Linari; Roberto Bottinelli; Maria Antonietta Pellegrino; Massimo Reconditi; Carlo Reggiani; Vincenzo Lombardi
The mechanism of the force response to stretch in human skinned muscle fibres with different myosin isoforms.
The Journal of physiology 2004;554(Pt 2):335-52.
2003: Massimo Reconditi; Natalia Koubassova; Marco Linari; Ian M Dobbie; Theyencheri Narayanan; O Diat; Gabriella Piazzesi; Vincenzo Lombardi; Malcolm Irving
The conformation of myosin head domains in rigor muscle determined by X-ray interference.
Biophysical journal 2003;85(2):1098-110.
2003: Gabriella Piazzesi; Massimo Reconditi; Natalia Koubassova; Valérie Decostre; Marco Linari; Leonardo Lucii; Vincenzo Lombardi
Temperature dependence of the force-generating process in single fibres from frog skeletal muscle.
The Journal of physiology 2003;549(Pt 1):93-106.
2002: Gabriella Piazzesi; Leonardo Lucii; Vincenzo Lombardi
The size and the speed of the working stroke of muscle myosin and its dependence on the force.
The Journal of physiology 2002;545(Pt 1):145-51.
2002: Gabriella Piazzesi; Massimo Reconditi; Marco Linari; Leonardo Lucii; Yin-Biao Sun; Theyencheri Narayanan; Peter Boesecke; Vincenzo Lombardi; Malcolm Irving
Mechanism of force generation by myosin heads in skeletal muscle.
Nature 2002;415(6872):659-62.
2000: Marco Linari; Leonardo Lucii; Massimo Reconditi; M E Casoni; Heinz Amenitsch; Sigrid Bernstorff; Gabriella Piazzesi; Vincenzo Lombardi
A combined mechanical and X-ray diffraction study of stretch potentiation in single frog muscle fibres.
The Journal of physiology 2000;526 Pt 3():589-96.
2000: Marco Linari; Gabriella Piazzesi; Ian M Dobbie; Natalia Koubassova; Massimo Reconditi; Theyencheri Narayanan; O Diat; Malcolm Irving; Vincenzo Lombardi
Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7226-31.
2000: Malcolm Irving; Gabriella Piazzesi; Leonardo Lucii; Yin-Biao Sun; J J Harford; Ian M Dobbie; Michael A Ferenczi; Massimo Reconditi; Vincenzo Lombardi
Conformation of the myosin motor during force generation in skeletal muscle.
Nature structural biology 2000;7(6):482-5.
1999: Gabriella Piazzesi; Massimo Reconditi; Ian M Dobbie; Marco Linari; Peter Boesecke; O Diat; Malcolm Irving; Vincenzo Lombardi
Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres.
The Journal of physiology 1999;514 ( Pt 2)():305-12.
1998: Ian M Dobbie; Marco Linari; Gabriella Piazzesi; Massimo Reconditi; Natalia Koubassova; Michael A Ferenczi; Vincenzo Lombardi; Malcolm Irving
Elastic bending and active tilting of myosin heads during muscle contraction.
Nature 1998;396(6709):383-7.
1998: Marco Linari; Ian M Dobbie; Massimo Reconditi; Natalia Koubassova; Malcolm Irving; Gabriella Piazzesi; Vincenzo Lombardi
The stiffness of skeletal muscle in isometric contraction and rigor: the fraction of myosin heads bound to actin.
Biophysical journal 1998;74(5):2459-73.
1998: Massimo Reconditi; Ian M Dobbie; Malcolm Irving; O Diat; Peter Boesecke; Marco Linari; Gabriella Piazzesi; Vincenzo Lombardi
Myosin head movements during isometric contraction studied by X-ray diffraction of single frog muscle fibres.
Advances in experimental medicine and biology 1998;453():265-70.
1998: Gabriella Piazzesi; Natalia Koubassova; Malcolm Irving; Vincenzo Lombardi
On the working stroke elicited by steps in length and temperature.
Advances in experimental medicine and biology 1998;453():259-63; discussion 263-4.
1997: Marco Linari; Vincenzo Lombardi; Gabriella Piazzesi
Cross-bridge kinetics studied with staircase shortening in single fibres from frog skeletal muscle.
Journal of muscle research and cell motility 1997;18(1):91-101.
1997: Gabriella Piazzesi; Marco Linari; Massimo Reconditi; Francesco Vanzi; Vincenzo Lombardi
Cross-bridge detachment and attachment following a step stretch imposed on active single frog muscle fibres.
The Journal of physiology 1997;498 ( Pt 1)():3-15.
1996: Gabriella Piazzesi; Vincenzo Lombardi
Simulation of the rapid regeneration of the actin-myosin working stroke with a tight coupling model of muscle contraction.
Journal of muscle research and cell motility 1996;17(1):45-53.
1995: Gabriella Piazzesi; Vincenzo Lombardi
A cross-bridge model that is able to explain mechanical and energetic properties of shortening muscle.
Biophysical journal 1995;68(5):1966-79.
1995: Vincenzo Lombardi; Gabriella Piazzesi; Michael A Ferenczi; H Thirlwell; Ian M Dobbie; Malcolm Irving
Elastic distortion of myosin heads and repriming of the working stroke in muscle.
Nature 1995;374(6522):553-5.
1995: Gabriella Piazzesi; Vincenzo Lombardi; Michael A Ferenczi; H Thirlwell; Ian M Dobbie; Malcolm Irving
Changes in the x-ray diffraction pattern from single, intact muscle fibers produced by rapid shortening and stretch.
Biophysical journal 1995;68(4 Suppl):92S-96S; discussion 96S-98S.
1995: Marco Linari; Ian M Dobbie; F Vanzi; K Torök; Malcolm Irving; Gabriella Piazzesi; Vincenzo Lombardi
Comparison between tension transients during isometric contraction and in rigor in isolated fibers from frog skeletal muscle.
Biophysical journal 1995;68(4 Suppl):218S.
1994: Gabriella Piazzesi; Marco Linari; Vincenzo Lombardi
The effect of hypertonicity on force generation in tetanized single fibres from frog skeletal muscle.
The Journal of physiology 1994;476(3):531-46.
1993: Gabriella Piazzesi; Marco Linari; Vincenzo Lombardi
Kinetics of regeneration of cross-bridge power stroke in shortening muscle.
Advances in experimental medicine and biology 1993;332():691-700; discussion 700-1.
1992: Malcolm Irving; Vincenzo Lombardi; Gabriella Piazzesi; Michael A Ferenczi
Myosin head movements are synchronous with the elementary force-generating process in muscle.
Nature 1992;357(6374):156-8.
1992: Vincenzo Lombardi; Gabriella Piazzesi; Marco Linari
Rapid regeneration of the actin-myosin power stroke in contracting muscle.
Nature 1992;355(6361):638-41.
1992: Gabriella Piazzesi; Fabio Francini; Marco Linari; Vincenzo Lombardi
Tension transients during steady lengthening of tetanized muscle fibres of the frog.
The Journal of physiology 1992;445():659-711.
1990: Vincenzo Lombardi; Gabriella Piazzesi
The contractile response during steady lengthening of stimulated frog muscle fibres.
The Journal of physiology 1990;431():141-71.
1989: Francesco Colomo; Vincenzo Lombardi; Gabriella Piazzesi
The recovery of tension in transients during steady lengthening of frog muscle fibres.
Pflügers Archiv : European journal of physiology 1989;414(2):245-7.
1989: Francesco Colomo; Vincenzo Lombardi; Gabriella Piazzesi
Steady lengthening of intact frog single muscle fibres reveals a fast cross-bridge turnover.
Progress in clinical and biological research 1989;315():229-30.
1988: Francesco Colomo; Vincenzo Lombardi; Gabriella Piazzesi
The mechanisms of force enhancement during constant velocity lengthening in tetanized single fibres of frog muscle.
Advances in experimental medicine and biology 1988;226():489-502.
1987: Giovanni Cecchi; Francesco Colomo; Vincenzo Lombardi; Gabriella Piazzesi
Stiffness of frog muscle fibres during rise of tension and relaxation in fixed-end or length-clamped tetani.
Pflügers Archiv : European journal of physiology 1987;409(1-2):39-46.
1986: Francesco Colomo; Vincenzo Lombardi; Gabriella Piazzesi
A velocity-dependent shortening depression in the development of the force-velocity relation in frog muscle fibres.
The Journal of physiology 1986;380():227-38.
1984: Giovanni Cecchi; Vincenzo Lombardi; G Menchetti
Development of force-velocity relation and rise of isometric tetanic tension measure the time course of different processes.
Pflügers Archiv : European journal of physiology 1984;401(4):396-401.
1984: C A Lorenzini; Francesco Colomo; Vincenzo Lombardi
Force-velocity relation and stiffness in frog single muscle fibres during the rise of tension in an isometric tetanus.
Advances in experimental medicine and biology 1984;170():757-64.
1983: C Ambrogi-Lorenzini; Francesco Colomo; Vincenzo Lombardi
Development of force-velocity relation, stiffness and isometric tension in frog single muscle fibres.
Journal of muscle research and cell motility 1983;4(2):177-89.
1981: Giovanni Cecchi; Francesco Colomo; Vincenzo Lombardi
Force-velocity relation in deuterium oxide-treated frog single muscle fibres during the rise of tension in an isometric tetanus.
The Journal of physiology 1981;317():207-21.