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Erwin London

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Chemicals & Drugs

Procedures

Fluorescence Spectrometry

Concepts & Ideas

Objects

Artificial Membranes

Phenomena

Fluorescence Polarization

Genes & Molecular Sequences

Amino Acid Sequence

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Network (preview)

Co-Publications
Name
8
Kachel, K
7
Brown, Deborah
6
Caputo, Gregory
6
Ren, J
5
Zhao, Gang
5
Megha,
5
Collier, Robert
4
Lew, Scott
4
Bakht, Omar
4
Malenbaum, SE
4
Xu, Xiaolian
4
Sharpe, JC
3
Rosconi, Michael
3
Ulbrandt, Nancy
3
Merrill, Rod

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Publications

TOP 3
Wang Jie; London Erwin
The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms.
London Erwin; Shahidullah Khurshida
Transmembrane vs. non-transmembrane hydrophobic helix topography in model and natural membranes.
Zhao Gang; London Erwin
Strong correlation between statistical transmembrane tendency and experimental hydrophobicity scales for identification of transmembrane helices.

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All Publications

2009: Wang Jie; London Erwin
The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms.
Biochemistry 2009;48(43):10446-56.
2009: London Erwin; Shahidullah Khurshida
Transmembrane vs. non-transmembrane hydrophobic helix topography in model and natural membranes.
Current opinion in structural biology 2009;19(4):464-72.
2009: Zhao Gang; London Erwin
Strong correlation between statistical transmembrane tendency and experimental hydrophobicity scales for identification of transmembrane helices.
The Journal of membrane biology 2009;229(3):165-8.
2009: Cheng Hui-Ting; Megha; London Erwin
Preparation and properties of asymmetric vesicles that mimic cell membranes: effect upon lipid raft formation and transmembrane helix orientation.
The Journal of biological chemistry 2009;284(10):6079-92.
2008: Shahidullah Khurshida; London Erwin
Effect of lipid composition on the topography of membrane-associated hydrophobic helices: stabilization of transmembrane topography by anionic lipids.
Journal of molecular biology 2008;379(4):704-18.
2008: Lai Bing; Zhao Gang; London Erwin
Behavior of the deeply inserted helices in diphtheria toxin T domain: helices 5, 8, and 9 interact strongly and promote pore formation, while helices 6/7 limit pore formation.
Biochemistry 2008;47(15):4565-74.
2008: Nelson Lindsay D; Johnson Arthur E; London Erwin
How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction.
The Journal of biological chemistry 2008;283(8):4632-42.
2007: Krishnakumar Shyam S; London Erwin
The control of transmembrane helix transverse position in membranes by hydrophilic residues.
Journal of molecular biology 2007;374(5):1251-69.
2007: Bakht Omar; Pathak Priyadarshini; London Erwin
Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): identification of multiple raft-stabilization mechanisms.
Biophysical journal 2007;93(12):4307-18.
2007: Krishnakumar Shyam S; London Erwin
Effect of sequence hydrophobicity and bilayer width upon the minimum length required for the formation of transmembrane helices in membranes.
Journal of molecular biology 2007;374(3):671-87.
2007: Megha; Sawatzki Peter; Kolter Thomas; Bittman Robert; London Erwin
Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts).
Biochimica et biophysica acta 2007;1768(9):2205-12.
2007: Bakht Omar; Delgado Javier; Amat-Guerri Francisco; Acuña A Ulises; London Erwin
The phenyltetraene lysophospholipid analog PTE-ET-18-OMe as a fluorescent anisotropy probe of liquid ordered membrane domains (lipid rafts) and ceramide-rich membrane domains.
Biochimica et biophysica acta 2007;1768(9):2213-21.
2007: Fujita Kentaro; Krishnakumar Shyam S; Franco David; Paul Aniko V; London Erwin; Wimmer Eckard
Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.
Biochemistry 2007;46(17):5185-99.
2007: Bakht Omar; London Erwin
Detecting ordered domain formation (lipid rafts) in model membranes using Tempo.
Methods in molecular biology (Clifton, N.J.) 2007;398():29-40.
2006: White Dawn; Musse Abdiwahab A; Wang Jie; London Erwin; Merrill A Rod
Toward elucidating the membrane topology of helix two of the colicin E1 channel domain.
The Journal of biological chemistry 2006;281(43):32375-84.
2006: Zhao Gang; London Erwin
An amino acid "transmembrane tendency" scale that approaches the theoretical limit to accuracy for prediction of transmembrane helices: relationship to biological hydrophobicity.
Protein science : a publication of the Protein Society 2006;15(8):1987-2001.
2006: Megha; Bakht Omar; London Erwin
Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders.
The Journal of biological chemistry 2006;281(31):21903-13.
2006: Wang Jie; Rosconi Michael P; London Erwin
Topography of the hydrophilic helices of membrane-inserted diphtheria toxin T domain: TH1-TH3 as a hydrophilic tether.
Biochemistry 2006;45(26):8124-34.
2006: Musse Abdiwahab A; Wang Jie; Deleon Gladys P; Prentice Gerry A; London Erwin; Merrill A Rod
Scanning the membrane-bound conformation of helix 1 in the colicin E1 channel domain by site-directed fluorescence labeling.
The Journal of biological chemistry 2006;281(2):885-95.
2005: London Erwin
How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells.
Biochimica et biophysica acta 2005;1746(3):203-20.
2005: Shogomori Hidehiko; Hammond Adam T; Ostermeyer-Fay Anne G; Barr Daniel J; Feigenson Gerald W; London Erwin; Brown Deborah A
Palmitoylation and intracellular domain interactions both contribute to raft targeting of linker for activation of T cells.
The Journal of biological chemistry 2005;280(19):18931-42.
2005: Zhao Gang; London Erwin
Behavior of diphtheria toxin T domain containing substitutions that block normal membrane insertion at Pro345 and Leu307: control of deep membrane insertion and coupling between deep insertion of hydrophobic subdomains.
Biochemistry 2005;44(11):4488-98.
2005: Hayashibara Masatoshi; London Erwin
Topography of diphtheria toxin A chain inserted into lipid vesicles.
Biochemistry 2005;44(6):2183-96.
2004: Rosconi Michael P; Zhao Gang; London Erwin
Analyzing topography of membrane-inserted diphtheria toxin T domain using BODIPY-streptavidin: at low pH, helices 8 and 9 form a transmembrane hairpin but helices 5-7 form stable nonclassical inserted segments on the cis side of the bilayer.
Biochemistry 2004;43(28):9127-39.
2004: Caputo Gregory A; London Erwin
Position and ionization state of Asp in the core of membrane-inserted alpha helices control both the equilibrium between transmembrane and nontransmembrane helix topography and transmembrane helix positioning.
Biochemistry 2004;43(27):8794-806.
2004: Megha; London Erwin
Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function.
The Journal of biological chemistry 2004;279(11):9997-10004.
2004: Wang Jiwei; Megha; London Erwin
Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function.
Biochemistry 2004;43(4):1010-8.
2003: Fastenberg Michael E; Shogomori Hidehiko; Xu Xiaolian; Brown Deborah A; London Erwin
Exclusion of a transmembrane-type peptide from ordered-lipid domains (rafts) detected by fluorescence quenching: extension of quenching analysis to account for the effects of domain size and domain boundaries.
Biochemistry 2003;42(42):12376-90.
2003: Lew Scott; Caputo Gregory A; London Erwin
The effect of interactions involving ionizable residues flanking membrane-inserted hydrophobic helices upon helix-helix interaction.
Biochemistry 2003;42(36):10833-42.
2003: Caputo Gregory A; London Erwin
Cumulative effects of amino acid substitutions and hydrophobic mismatch upon the transmembrane stability and conformation of hydrophobic alpha-helices.
Biochemistry 2003;42(11):3275-85.
2003: Caputo Gregory A; London Erwin
Using a novel dual fluorescence quenching assay for measurement of tryptophan depth within lipid bilayers to determine hydrophobic alpha-helix locations within membranes.
Biochemistry 2003;42(11):3265-74.
2002: London Erwin
Insights into lipid raft structure and formation from experiments in model membranes.
Current opinion in structural biology 2002;12(4):480-6.
2002: Rosconi Michael P; London Erwin
Topography of helices 5-7 in membrane-inserted diphtheria toxin T domain: identification and insertion boundaries of two hydrophobic sequences that do not form a stable transmembrane hairpin.
The Journal of biological chemistry 2002;277(19):16517-27.
2002: Hammond Kelli; Caputo Gregory A; London Erwin
Interaction of the membrane-inserted diphtheria toxin T domain with peptides and its possible implications for chaperone-like T domain behavior.
Biochemistry 2002;41(9):3243-53.
2002: Dhanvantari Savita; Arnaoutova Irina; Snell Chris R; Steinbach Peter J; Hammond Kelli; Caputo Gregory A; London Erwin; Loh Y Peng
Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion.
Biochemistry 2002;41(1):52-60.
2001: Xu X; Bittman R; Duportail G; Heissler D; Vilcheze C; London E
Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide.
The Journal of biological chemistry 2001;276(36):33540-6.
2000: London E; Brown D A
Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).
Biochimica et biophysica acta 2000;1508(1-2):182-95.
2000: Lew S; Ren J; London E
The effects of polar and/or ionizable residues in the core and flanking regions of hydrophobic helices on transmembrane conformation and oligomerization.
Biochemistry 2000;39(32):9632-40.
2000: Xu X; London E
The effect of sterol structure on membrane lipid domains reveals how cholesterol can induce lipid domain formation.
Biochemistry 2000;39(5):843-9.
2000: London E; Brown D A; Xu X
Fluorescence quenching assay of sphingolipid/phospholipid phase separation in model membranes.
Methods in enzymology 2000;312():272-90.
1999: Sharpe J C; Kachel K; London E
The effects of inhibitors upon pore formation by diphtheria toxin and diphtheria toxin T domain.
The Journal of membrane biology 1999;171(3):223-33.
1999: Sharpe J C; London E
Diphtheria toxin forms pores of different sizes depending on its concentration in membranes: probable relationship to oligomerization.
The Journal of membrane biology 1999;171(3):209-21.
1999: Ren J; Kachel K; Kim H; Malenbaum S E; Collier R J; London E
Interaction of diphtheria toxin T domain with molten globule-like proteins and its implications for translocation.
Science (New York, N.Y.) 1999;284(5416):955-7.
1999: Ren J; Lew S; Wang J; London E
Control of the transmembrane orientation and interhelical interactions within membranes by hydrophobic helix length.
Biochemistry 1999;38(18):5905-12.
1999: Ren J; Sharpe J C; Collier R J; London E
Membrane translocation of charged residues at the tips of hydrophobic helices in the T domain of diphtheria toxin.
Biochemistry 1999;38(3):976-84.
1998: Malenbaum S E; Collier R J; London E
Membrane topography of the T domain of diphtheria toxin probed with single tryptophan mutants.
Biochemistry 1998;37(51):17915-22.
1998: Malenbaum S E; Merrill A R; London E
Membrane-inserted colicin E1 channel domain: a topological survey by fluorescence quenching suggests that model membrane thickness affects membrane penetration.
Journal of natural toxins 1998;7(3):269-90.
1998: Kaiser R D; London E
Determination of the depth of BODIPY probes in model membranes by parallax analysis of fluorescence quenching.
Biochimica et biophysica acta 1998;1375(1-2):13-22.
1998: Kachel K; Asuncion-Punzalan E; London E
The location of fluorescence probes with charged groups in model membranes.
Biochimica et biophysica acta 1998;1374(1-2):63-76.
1998: Kachel K; Ren J; Collier R J; London E
Identifying transmembrane states and defining the membrane insertion boundaries of hydrophobic helices in membrane-inserted diphtheria toxin T domain.
The Journal of biological chemistry 1998;273(36):22950-6.
1998: Brown D A; London E
Structure and origin of ordered lipid domains in biological membranes.
The Journal of membrane biology 1998;164(2):103-14.
1998: Kaiser R D; London E
Location of diphenylhexatriene (DPH) and its derivatives within membranes: comparison of different fluorescence quenching analyses of membrane depth.
Biochemistry 1998;37(22):8180-90.
1998: Asuncion-Punzalan E; Kachel K; London E
Groups with polar characteristics can locate at both shallow and deep locations in membranes: the behavior of dansyl and related probes.
Biochemistry 1998;37(13):4603-11.
1998: Schroeder R J; Ahmed S N; Zhu Y; London E; Brown D A
Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains.
The Journal of biological chemistry 1998;273(2):1150-7.
1998: Brown D A; London E
Functions of lipid rafts in biological membranes.
Annual review of cell and developmental biology 1998;14():111-36.
1997: Wang Y; Kachel K; Pablo L; London E
Use of Trp mutations to evaluate the conformational behavior and membrane insertion of A and B chains in whole diphtheria toxin.
Biochemistry 1997;36(51):16300-8.
1997: Brown D A; London E
Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes?
Biochemical and biophysical research communications 1997;240(1):1-7.
1997: Wang Y; Malenbaum S E; Kachel K; Zhan H; Collier R J; London E
Identification of shallow and deep membrane-penetrating forms of diphtheria toxin T domain that are regulated by protein concentration and bilayer width.
The Journal of biological chemistry 1997;272(40):25091-8.
1997: Ahmed S N; Brown D A; London E
On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes.
Biochemistry 1997;36(36):10944-53.
1997: Lew S; London E
Simple procedure for reversed-phase high-performance liquid chromatographic purification of long hydrophobic peptides that form transmembrane helices.
Analytical biochemistry 1997;251(1):113-6.
1997: Ren J; Lew S; Wang Z; London E
Transmembrane orientation of hydrophobic alpha-helices is regulated both by the relationship of helix length to bilayer thickness and by the cholesterol concentration.
Biochemistry 1997;36(33):10213-20.
1997: Sharpe J C; London E
Inadvertent concentrating of EDTA by ion exchange chromatography: avoiding artifacts that can interfere with protein purification.
Analytical biochemistry 1997;250(1):124-5.
1996: Paliwal R; London E
Comparison of the conformation, hydrophobicity, and model membrane interactions of diphtheria toxin to those of formaldehyde-treated toxin (diphtheria toxoid): formaldehyde stabilization of the native conformation inhibits changes that allow membrane insertion.
Biochemistry 1996;35(7):2374-9.
1995: Tortorella D; Sesardic D; Dawes C S; London E
Immunochemical analysis shows all three domains of diphtheria toxin penetrate across model membranes.
The Journal of biological chemistry 1995;270(46):27446-52.
1995: Tortorella D; Sesardic D; Dawes C S; London E
Immunochemical analysis of the structure of diphtheria toxin shows all three domains undergo structural changes at low pH.
The Journal of biological chemistry 1995;270(46):27439-45.
1995: Kachel K; Asuncion-Punzalan E; London E
Anchoring of tryptophan and tyrosine analogs at the hydrocarbon-polar boundary in model membrane vesicles: parallax analysis of fluorescence quenching induced by nitroxide-labeled phospholipids.
Biochemistry 1995;34(47):15475-9.
1995: Asuncion-Punzalan E; London E
Control of the depth of molecules within membranes by polar groups: determination of the location of anthracene-labeled probes in model membranes by parallax analysis of nitroxide-labeled phospholipid induced fluorescence quenching.
Biochemistry 1995;34(36):11460-6.
1994: Schroeder R; London E; Brown D
Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12130-4.
1994: Tortorella D; London E
Method for efficient pelleting of small unilamellar model membrane vesicles.
Analytical biochemistry 1994;217(2):176-80.
1993: Abrams F S; London E
Extension of the parallax analysis of membrane penetration depth to the polar region of model membranes: use of fluorescence quenching by a spin-label attached to the phospholipid polar headgroup.
Biochemistry 1993;32(40):10826-31.
1993: Tortorella D; Ulbrandt N D; London E
Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding.
Biochemistry 1993;32(35):9181-8.
1993: London E; Ulbrandt N D; Tortorella D; Jiang J X; Abrams F S
Insights into membrane protein folding and translocation from the behavior of bacterial toxins: models for membrane translocation.
Society of General Physiologists series 1993;48():45-61.
1992: London E
How bacterial protein toxins enter cells; the role of partial unfolding in membrane translocation.
Molecular microbiology 1992;6(22):3277-82.
1992: Ulbrandt N D; London E; Oliver D B
Deep penetration of a portion of Escherichia coli SecA protein into model membranes is promoted by anionic phospholipids and by partial unfolding.
The Journal of biological chemistry 1992;267(21):15184-92.
1992: Abrams F S; Chattopadhyay A; London E
Determination of the location of fluorescent probes attached to fatty acids using parallax analysis of fluorescence quenching: effect of carboxyl ionization state and environment on depth.
Biochemistry 1992;31(23):5322-7.
1992: Abrams F S; London E
Calibration of the parallax fluorescence quenching method for determination of membrane penetration depth: refinement and comparison of quenching by spin-labeled and brominated lipids.
Biochemistry 1992;31(23):5312-22.
1992: London E
Diphtheria toxin: membrane interaction and membrane translocation.
Biochimica et biophysica acta 1992;1113(1):25-51.
1991: Jiang J X; Chung L A; London E
Self-translocation of diphtheria toxin across model membranes.
The Journal of biological chemistry 1991;266(35):24003-10.
1991: Jiang J X; Abrams F S; London E
Folding changes in membrane-inserted diphtheria toxin that may play important roles in its translocation.
Biochemistry 1991;30(16):3857-64.
1990: Kieleczawa J; Zhao J M; Luongo C L; Dong L Y; London E
The effect of high pH upon diphtheria toxin conformation and model membrane association: role of partial unfolding.
Archives of biochemistry and biophysics 1990;282(2):214-20.
1990: Jiang J X; London E
Involvement of denaturation-like changes in Pseudomonas exotoxin a hydrophobicity and membrane penetration determined by characterization of pH and thermal transitions. Roles of two distinct conformationally altered states.
The Journal of biological chemistry 1990;265(15):8636-41.
1989: London E; Luongo C L
Domain-specific bias in arginine/lysine usage by protein toxins.
Biochemical and biophysical research communications 1989;160(1):333-9.
1988: Zhao J M; London E
Conformation and model membrane interactions of diphtheria toxin fragment A.
The Journal of biological chemistry 1988;263(30):15369-77.
1988: Zhao J M; London E
Localization of the active site of diphtheria toxin.
Biochemistry 1988;27(9):3398-403.
1988: Chung L A; London E
Interaction of diphtheria toxin with model membranes.
Biochemistry 1988;27(4):1245-53.
1988: Chattopadhyay A; London E
Spectroscopic and ionization properties of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled lipids in model membranes.
Biochimica et biophysica acta 1988;938(1):24-34.
1986: Zhao J M; London E
Similarity of the conformation of diphtheria toxin at high temperature to that in the membrane-penetrating low-pH state.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2002-6.
1985: Blewitt M G; Chung L A; London E
Effect of pH on the conformation of diphtheria toxin and its implications for membrane penetration.
Biochemistry 1985;24(20):5458-64.
1984: Blewitt M G; Chao J M; McKeever B; Sarma R; London E
Fluorescence characterization of the low pH-induced change in diphtheria toxin conformation: effect of salt.
Biochemical and biophysical research communications 1984;120(1):286-90.

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