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Maria Letizia Barreca

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Chemicals & Drugs

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Maria Letizia Barreca; Amartya Basu; U Helena Danielson; Nunzio Iraci; Neerja Kaushik-Basu; Ramalingam Krishnan; Pieter Leyssen; Giuseppe Manfroni; Johan Neyts; Jan Paeshuyse; Stefano Sabatini; Oriana Tabarrini; Johan Winquist; Violetta Cecchetti
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.
Giuseppe Manfroni; Serena Massari; Francesco Meschini; Johan Neyts; Stefano Sabatini; Alberta Samuele; Maria Letizia Barreca; Nunzio Iraci; Pieter Leyssen; Giovanni Maga; Violetta Cecchetti
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
Iart Luca Shytaj; Jake Yalley-Ogunro; Edward P Acosta; Maria Letizia Barreca; Barbara Chirullo; Matt Collins; Alessandro Della Corte; Jack Greenhouse; Nunzio Iraci; Mark G Lewis; Sandro Norelli; Andrea Savarino
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.

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All Publications

2013: Maria Letizia Barreca; Amartya Basu; U Helena Danielson; Nunzio Iraci; Neerja Kaushik-Basu; Ramalingam Krishnan; Pieter Leyssen; Giuseppe Manfroni; Johan Neyts; Jan Paeshuyse; Stefano Sabatini; Oriana Tabarrini; Johan Winquist; Violetta Cecchetti
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.
Journal of medicinal chemistry 2013;56(6):2270-82.
2012: Giuseppe Manfroni; Serena Massari; Francesco Meschini; Johan Neyts; Stefano Sabatini; Alberta Samuele; Maria Letizia Barreca; Nunzio Iraci; Pieter Leyssen; Giovanni Maga; Violetta Cecchetti
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
Bioorganic & medicinal chemistry 2012;20(2):866-76.
2012: Iart Luca Shytaj; Jake Yalley-Ogunro; Edward P Acosta; Maria Letizia Barreca; Barbara Chirullo; Matt Collins; Alessandro Della Corte; Jack Greenhouse; Nunzio Iraci; Mark G Lewis; Sandro Norelli; Andrea Savarino
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.
PLoS pathogens 2012;8(6):e1002774.
2011: Maria Letizia Barreca; Nunzio Iraci; Giuseppe Manfroni; Violetta Cecchetti
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.
Future medicinal chemistry 2011;3(8):1027-55.
2010: Laura De Luca; Stefania Ferro; Rosaria Gitto; Maria Letizia Barreca; Stefano Agnello; Frauke Christ; zeger debyser; Alba Chimirri
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.
Bioorganic & medicinal chemistry 2010;18(21):7515-21.
2010: Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Sara De Grazia; Frauke Christ; zeger debyser; Alba Chimirri
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.
Bioorganic & medicinal chemistry 2010;18(15):5510-8.
2010: Serena Massari; Dirk Daelemans; Maria Letizia Barreca; Anna Knezevich; Stefano Sabatini; Violetta Cecchetti; Alessandro Marcello; Christophe Pannecouque; Oriana Tabarrini
A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.
Journal of medicinal chemistry 2010;53(2):641-8.
2010: Mark G Lewis; Sandro Norelli; Matt Collins; Maria Letizia Barreca; Nunzio Iraci; Barbara Chirullo; Jake Yalley-Ogunro; Jack Greenhouse; Fausto Titti; Enrico Garaci; Andrea Savarino
Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy.
Retrovirology 2010;7():21.
2009: Maria Letizia Barreca; Nunzio Iraci; Laura De Luca; Alba Chimirri
Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.
ChemMedChem 2009;4(9):1446-56.
2009: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Frauke Christ; Nunzio Iraci; Rosaria Gitto; Anna Maria Monforte; zeger debyser; Alba Chimirri
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.
ChemMedChem 2009;4(8):1311-6.
2008: Anna Maria Monforte; Angela Rao; Patrizia Logoteta; Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Nunzio Iraci; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(15):7429-35.
2008: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Nunzio Iraci; Martine Michiels; Frauke Christ; zeger debyser; Myriam Witvrouw; Alba Chimirri
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Bioorganic & medicinal chemistry letters 2008;18(9):2891-5.
2007: Maria Letizia Barreca; Francesco Ortuso; Nunzio Iraci; Laura De Luca; Stefano Alcaro; Alba Chimirri
Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode.
Biochemical and biophysical research communications 2007;363(3):554-60.
2007: Rosaria Gitto; Rita Ficarra; Rosanna Stancanelli; Marta Guardo; Laura De Luca; Maria Letizia Barreca; Benedetta Pagano; Archimede Rotondo; Giuseppe Bruno; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists.
Bioorganic & medicinal chemistry 2007;15(16):5417-23.
2007: Stefania Ferro; Maria Letizia Barreca; Laura De Luca; Angela Rao; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Archiv der Pharmazie 2007;340(6):292-8.
2007: Maria Letizia Barreca; Angela Rao; Laura De Luca; Nunzio Iraci; Anna Maria Monforte; giovanni maga; Erik De Clercq; Christophe Pannecouque; Jan Balzarini; Alba Chimirri
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Bioorganic & medicinal chemistry letters 2007;17(7):1956-60.
2007: Maria Letizia Barreca; Laura De Luca; Nunzio Iraci; Angela Rao; Stefania Ferro; giovanni maga; Alba Chimirri
Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors.
Journal of chemical information and modeling 2007;47(2):557-62.
2007: Andrea Savarino; Mauro Pistello; Daniela D'Ostilio; Elisa Zabogli; Fabiana Taglia; Fabiola Mancini; Stefania Ferro; Donatella Matteucci; Laura De Luca; Maria Letizia Barreca; Alessandra Ciervo; Alba Chimirri; Massimo Ciccozzi; Mauro Bendinelli
Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS.
Retrovirology 2007;4():79.
2006: Laura De Luca; Rosaria Gitto; Maria Letizia Barreca; Roberta Caruso; Silvana Quartarone; Rita Citraro; Giovambattista De Sarro; Alba Chimirri
3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.
Archiv der Pharmazie 2006;339(7):388-400.
2006: Maria Letizia Barreca; Laura De Luca; Nunzio Iraci; Alba Chimirri
Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase.
Journal of medicinal chemistry 2006;49(13):3994-7.
2005: Laura De Luca; Giulio Vistoli; Alessandro Pedretti; Maria Letizia Barreca; Alba Chimirri
Molecular dynamics studies of the full-length integrase-DNA complex.
Biochemical and biophysical research communications 2005;336(4):1010-6.
2005: Maria Letizia Barreca; Stefania Ferro; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Journal of medicinal chemistry 2005;48(22):7084-8.
2005: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; giovanni maga; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; Alba Chimirri; Pietro Monforte
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Journal of medicinal chemistry 2005;48(9):3433-7.
2005: Giovambattista De Sarro; Rosaria Gitto; Emilio Russo; Guido Ferreri Ibbadu; Maria Letizia Barreca; Laura De Luca; Alba Chimirri
AMPA receptor antagonists as potential anticonvulsant drugs.
Current topics in medicinal chemistry 2005;5(1):31-42.
2004: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Cristina Gurnari; Pietro Monforte; Erik De Clercq; Bénédicte Van Maele; zeger debyser; Myriam Witvrouw; James M Briggs; Alba Chimirri
Efficient 3D database screening for novel HIV-1 IN inhibitors.
Journal of chemical information and computer sciences 2004;44(4):1450-5.
2004: Antonio Macchiarulo; Laura De Luca; Gabriele Costantino; Maria Letizia Barreca; Rosaria Gitto; Roberto Pellicciari; Alba Chimirri
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor.
Journal of medicinal chemistry 2004;47(7):1860-3.
2004: Rosaria Gitto; Roberta Caruso; Valérie Orlando; Silvana Quartarone; Maria Letizia Barreca; Guido Ferreri; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives.
Farmaco (Società chimica italiana : 1989) 2004;59(1):7-12.
2003: Laura De Luca; Alessandro Pedretti; Giulio Vistoli; Maria Letizia Barreca; Luigi Villa; Pietro Monforte; Alba Chimirri
Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.
Biochemical and biophysical research communications 2003;310(4):1083-8.
2003: Maria Letizia Barreca; Rosaria Gitto; Silvana Quartarone; Laura De Luca; Giovambattista De Sarro; Alba Chimirri
Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists.
Journal of chemical information and computer sciences 2003;43(2):651-5.
2003: Maria Letizia Barreca; Alba Chimirri; Erik De Clercq; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà
Anti-HIV agents: design and discovery of new potent RT inhibitors.
Farmaco (Società chimica italiana : 1989) 2003;58(3):259-63.
2003: Maria Letizia Barreca; Keun Woo Lee; Alba Chimirri; James M Briggs
Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance.
Biophysical journal 2003;84(3):1450-63.
2003: Laura De Luca; Antonio Macchiarulo; Gabriele Costantino; Maria Letizia Barreca; Rosaria Gitto; Alba Chimirri; Roberto Pellicciari
Binding modes of noncompetitive AMPA antagonists: a computational approach.
Farmaco (Società chimica italiana : 1989) 2003;58(2):107-13.
2003: Rosaria Gitto; Maria Letizia Barreca; Laura De Luca; Giovambattista De Sarro; Guido Ferreri; Silvana Quartarone; Emilio Russo; Andrew Constanti; Alba Chimirri
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist.
Journal of medicinal chemistry 2003;46(1):197-200.
2002: Maria Letizia Barreca; Jan Balzarini; Alba Chimirri; Erik De Clercq; Laura De Luca; Hans-Dieter Höltje; Monika Höltje; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Angela Rao; Maria Zappalà
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Journal of medicinal chemistry 2002;45(24):5410-3.
2002: Antonio Carrieri; Angelo Carotti; Maria Letizia Barreca; Cosimo Altomare
Binding models of reversible inhibitors to type-B monoamine oxidase.
Journal of computer-aided molecular design 2002;16(11):769-78.
2001: Maria Letizia Barreca; Alba Chimirri; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1793-6.
1999: Maria Letizia Barreca; Angelo Carotti; Antonio Carrieri; Alba Chimirri; Anna Maria Monforte; M P Calace; Angela Rao
Comparative molecular field analysis (CoMFA) and docking studies of non-nucleoside HIV-1 RT inhibitors (NNIs).
Bioorganic & medicinal chemistry 1999;7(11):2283-92.