FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kenton Longenecker

Research Profile

Concepts & Ideas

Chemicals & Drugs

Procedures

X Ray Crystallography

Living Beings

Occupations

Drug Design

Phenomena

X-Ray Diffraction

Co-author Network

Publications

TOP 3
Wenying Qin; Larry R Solomon; Russell A Judge; Kenton Longenecker; John E Harlan
On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1.
Zhonghua Pei; Xiaofeng Li; Thomas W von Geldern; Kenton Longenecker; Daisy Pireh; Kent D Stewart; Bradley J Backes; Chunqiu Lai; Thomas H Lubben; Stephen J Ballaron; David W A Beno; Anita J Kempf-Grote; Hing L Sham; James M Trevillyan
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
Bradley J Backes; Kenton Longenecker; Gregory L Hamilton; Kent Stewart; Chunqiu Lai; Hana Kopecka; Thomas W von Geldern; David J Madar; Zhonghua Pei; Thomas H Lubben; Bradley A Zinker; Zhenping Tian; Stephen J Ballaron; Michael Stashko; Amanda K Mika; David W A Beno; Anita J Kempf-Grote; Candace Black-Schaefer; Hing L Sham; James M Trevillyan
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kenton Longenecker (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Wenying Qin; Larry R Solomon; Russell A Judge; Kenton Longenecker; John E Harlan
On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 5):601-5.
2007: Zhonghua Pei; Xiaofeng Li; Thomas W von Geldern; Kenton Longenecker; Daisy Pireh; Kent D Stewart; Bradley J Backes; Chunqiu Lai; Thomas H Lubben; Stephen J Ballaron; David W A Beno; Anita J Kempf-Grote; Hing L Sham; James M Trevillyan
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
Journal of medicinal chemistry 2007;50(8):1983-7.
2007: Bradley J Backes; Kenton Longenecker; Gregory L Hamilton; Kent Stewart; Chunqiu Lai; Hana Kopecka; Thomas W von Geldern; David J Madar; Zhonghua Pei; Thomas H Lubben; Bradley A Zinker; Zhenping Tian; Stephen J Ballaron; Michael Stashko; Amanda K Mika; David W A Beno; Anita J Kempf-Grote; Candace Black-Schaefer; Hing L Sham; James M Trevillyan
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorganic & medicinal chemistry letters 2007;17(7):2005-12.
2007: Jyoti R Patel; Qi Shuai; Jurgen Dinges; Martin Winn; Marina Pliushchev; Steven Fung; Katina Monzon; William Chiou; Jiahong Wang; Liping Pan; Seble H Wagaw; Kenneth M Engstrom; Francis A Kerdesky; Kenton Longenecker; Russell A Judge; Wenying Qin; Hovis Imade; Deanne Stolarik; David W A Beno; Michael Brune; Linda E Chovan; Hing L Sham; Peer Jacobson; James T Link
Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2007;17(3):750-5.
2007: Bryan K Sorensen; Martin Winn; Jeff Rohde; Qi Shuai; Jiahong Wang; Steven Fung; Katina Monzon; William Chiou; Deanne Stolarik; Hovis Imade; Liping Pan; Xiaoqing Deng; Linda E Chovan; Kenton Longenecker; Russell A Judge; Wenying Qin; Michael Brune; Heidi S Camp; Ernst U Frevert; Peer Jacobson; James T Link
Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(2):527-32.
2006: Ravi Kurukulasuriya; Jeffrey J Rohde; Bruce G Szczepankiewicz; Fatima Basha; Chunqiu Lai; Hwan-Soo Jae; Martin Winn; Kent D Stewart; Kenton Longenecker; Thomas W Lubben; Stephen J Ballaron; Hing L Sham; Thomas W von Geldern
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(24):6226-30.
2006: Zhonghua Pei; Xiaofeng Li; Thomas W von Geldern; David J Madar; Kenton Longenecker; Hong Yong; Thomas H Lubben; Kent D Stewart; Bradley A Zinker; Bradley J Backes; Andrew S Judd; Mathew M Mulhern; Stephen J Ballaron; Michael Stashko; Amanda K Mika; David W A Beno; Glenn A Reinhart; Ryan M Fryer; Lee C Preusser; Anita J Kempf-Grote; Hing L Sham; James M Trevillyan
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2006;49(22):6439-42.
2006: Kenton Longenecker; Kent D Stewart; David J Madar; Clarissa Jakob; Elizabeth H Fry; Sherwin Wilk; Chun W Lin; Stephen J Ballaron; Michael Stashko; Thomas H Lubben; Hong Yong; Daisy Pireh; Zhonghua Pei; Fatima Basha; Paul E Wiedeman; Thomas W von Geldern; James M Trevillyan; Vincent S Stoll
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.
Biochemistry 2006;45(24):7474-82.
2006: Zhonghua Pei; Xiaofeng Li; Kenton Longenecker; Thomas W von Geldern; Paul E Wiedeman; Thomas H Lubben; Bradley A Zinker; Kent Stewart; Stephen J Ballaron; Michael Stashko; Amanda K Mika; David W A Beno; Michelle Long; Heidi Wells; Anita J Kempf-Grote; David J Madar; Todd S McDermott; Lakshmi Bhagavatula; Michael G Fickes; Daisy Pireh; Larry R Solomon; Marc R Lake; Rohinton Edalji; Elizabeth H Fry; Hing L Sham; James M Trevillyan
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
Journal of medicinal chemistry 2006;49(12):3520-35.
2006: Geoffrey F Stamper; Kenton Longenecker; Elizabeth H Fry; Clarissa Jakob; Alan S Florjancic; Yu Gui Gu; David D Anderson; Curt S Cooper; Tianyuan Zhang; Richard F Clark; Yingna Cia; Candace Black-Schaefer; J Owen McCall; Claude G Lerner; Philip J Hajduk; Bruce A Beutel; Vincent S Stoll
Structure-based optimization of MurF inhibitors.
Chemical biology & drug design 2006;67(1):58-65.
2005: Kenton Longenecker; Geoffrey F Stamper; Philip J Hajduk; Elizabeth H Fry; Clarissa Jakob; John Harlan; Rohinton Edalji; Diane M Bartley; Karl A Walter; Larry R Solomon; Thomas F Holzman; Yu Gui Gu; Claude G Lerner; Bruce A Beutel; Vincent S Stoll
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.
Protein science : a publication of the Protein Society 2005;14(12):3039-47.