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Thomas Look

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Rie Suganuma; Larry L Wang; Gabriele Amann; Klaus Beiske; Susan Cohn; Catherine J Cullinane; Emanuele S G d'Amore; Claudio Gambini; Julie M Gastier-Foster; Michael D Hogarty; JA Jarzembowski; Vijay V Joshi; Wendy B London; A Thomas Look; John M Maris; Arlene Naranjo; Samuel Navarro; Julie R Park; Michel Peuchmaur; Hideki Sano; Robert C Seeger; Hiroyuki Shimada
Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.
J Etchin; A Farmer; M Kauffman; Alex Kentsis; Andrew L Kung; M R Mansour; D McCauley; S J Rodig; T Sanda; Sharon Shacham; Q Sun; Z C Zhang; C Barcelo; Y M Chook; A L Christie; A Thomas Look
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Shuyun Rao; Michele Rhodes; Joseph R Testa; Roshan J Thapa; Roman A Timakhov; Zhigang Tu; Gerard P Zambetti; Rugang Zhang; Stephen Anderson; Siddharth Balachandran; Alejandro Gutierrez; Stephen P Hunger; John R Jeffers; Sang-Yun Lee; A Thomas Look; Tamas Oravecz; Jacqueline Perrigoue; David L Wiest
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

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All Publications

2013: Rie Suganuma; Larry L Wang; Gabriele Amann; Klaus Beiske; Susan Cohn; Catherine J Cullinane; Emanuele S G d'Amore; Claudio Gambini; Julie M Gastier-Foster; Michael D Hogarty; JA Jarzembowski; Vijay V Joshi; Wendy B London; A Thomas Look; John M Maris; Arlene Naranjo; Samuel Navarro; Julie R Park; Michel Peuchmaur; Hideki Sano; Robert C Seeger; Hiroyuki Shimada
Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.
Pediatric blood & cancer 2013;60(3):363-70.
2013: J Etchin; A Farmer; M Kauffman; Alex Kentsis; Andrew L Kung; M R Mansour; D McCauley; S J Rodig; T Sanda; Sharon Shacham; Q Sun; Z C Zhang; C Barcelo; Y M Chook; A L Christie; A Thomas Look
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Leukemia 2013;27(1):66-74.
2012: Shuyun Rao; Michele Rhodes; Joseph R Testa; Roshan J Thapa; Roman A Timakhov; Zhigang Tu; Gerard P Zambetti; Rugang Zhang; Stephen Anderson; Siddharth Balachandran; Alejandro Gutierrez; Stephen P Hunger; John R Jeffers; Sang-Yun Lee; A Thomas Look; Tamas Oravecz; Jacqueline Perrigoue; David L Wiest
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
Blood 2012;120(18):3764-73.
2012: Jimann Shin; Lilianna Solnica-Krezel; Scot A Wolfe; Marc A Wolman; Arun Padmanabhan; Suzanne Dahlberg; Eric D de Groh; Jonathan A Epstein; Michael Granato; Feng Guo; Sam Haidar; Shuning He; John P Kanki; Seok-Hyung Kim; Nathan D Lawson; Jeong-Soo Lee; Keith L Ligon; A Thomas Look
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
Disease models & mechanisms 2012;5(6):881-94.
2012: Yoon Jong Choi; Amanda L Christie; Per Hydbring; Andrew L Kung; Xiaoyu Li; A Thomas Look; Takaomi Sanda; Sabina Signoretti; Joanna Stefano; Harald von Boehmer; Piotr Sicinski
The requirement for cyclin D function in tumor maintenance.
Cancer cell 2012;22(4):438-51.
2012: Kiyohiro Ando; Lisa Bouchier-Hayes; Jennifer L Kernan; Peter H Liu; Emmanuelle Logette; A Thomas Look; Takaomi Sanda; Jurg Tschopp; Jianlong Wang; Samuel Sidi
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
Molecular cell 2012;47(5):681-93.
2012: Elspeth M Payne; Hong Sun; Maria Virgilio; Nancy Berliner; Benjamin L Ebert; Michelle Levine; A Thomas Look; Anupama Narla; Barry H Paw; Arati Khanna-Gupta
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.
Blood 2012;120(11):2214-24.
2012: Alex Kentsis; A Thomas Look
Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis.
Cell stem cell 2012;11(3):281-2.
2012: J S Blackburn; H Feng; J Gentry; A Bernards; S Liu; A Thomas Look; S A Martinez; N D Meeker; Donna Neuberg; D M Raiser; S Ramaswamy; Nikolaus S Trede; David M Langenau
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.
Leukemia 2012;26(9):2069-78.
2012: Takaomi Sanda; Louis M Staudt; Jessica Tatarek; Richard A Young; Wenxue Ma; Yebin Ahn; M Inmaculada Barrasa; Zi Peng Fan; Alejandro Gutierrez; Catriona H M Jamieson; Michelle A Kelliher; Holger Kohlhammer; Lee N Lawton; A Thomas Look
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Cancer cell 2012;22(2):209-21.
2012: Alex Kentsis; Andrew L Kung; Jeffery L Kutok; Jonathan D Licht; Richard J Byers; James G Christensen; Amanda Christie; Suzanne E Dahlberg; Ruud Delwel; Lisa A Moreau; Vu Ngo; Casie Reed; Kim L Rice; Scott J Rodig; Takaomi Sanda; Louis M Staudt; Eleni Tholouli; Peter J M Valk; George Vande Woude; A Thomas Look
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
Nature medicine 2012;18(7):1118-22.
2012: Qingsong Liu; A Thomas Look; Jing Ni; Mario Niepel; Matthew P Patricelli; Steve Riddle; David M Sabatini; Takaomi Sanda; Peter K Sorger; Carson C Thoreen; Ryan Traynor; Kurt Vogel; David L Waller; Jinhua Wang; Kenneth Westover; Jean Zhao; Zheng Zhao; Wooyoung Hur; Seong A Kang; Sivapriya Kirubakaran; Nathanael S Gray
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
The Journal of biological chemistry 2012;287(13):9742-52.
2012: Shizhen Zhu; Donna Neuberg; Antonio R Perez-Atayde; Scott J Rodig; Jimann Shin; Rodney A Stewart; Wenchao Wang; Hui Feng; Rani E George; Feng Guo; Daniel Helman; John P Kanki; Jeffery L Kutok; Jeong-Soo Lee; A Thomas Look
Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.
Cancer cell 2012;21(3):362-73.
2012: Shelly Sorrells; Rodney A Stewart; Yi Zhou; Leonard I Zon; Seth Carbonneau; Aye T Chen; Erik Harrington; Bridgid Hast; A Thomas Look; Michael Ben Major; Brett Milash; Ujwal Pyati; Cicely Jette
Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.
PLoS genetics 2012;8(8):e1002922.
2012: Wenxue Ma; Sheldon R Morris; Anil Sadarangani; Alice Y Shih; Kristen M Smith; Ping Wei; Christina C Wu; QINGFEI JIANG; Kang Li; A Thomas Look; Dennis A Carson; Angela C Court; Leslie Crews; Ida Deichaite; Ifat Geron; Neil W Gibson; Daniel J Goff; Alejandro Gutierrez; Christina A M Jamieson; Catriona H M Jamieson
NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.
PloS one 2012;7(6):e39725.
2011: Marc R Mansour; A Thomas Look
Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.
Cancer cell 2011;20(5):559-61.
2011: Alejandro Gutierrez; Linda Holmfeldt; Stephen P Hunger; Alex Kentsis; Frederick W Alt; Shann-Ching Chen; Lynda Chin; Suzanne E Dahlberg; James R Downing; Charles G Mullighan; Donna Neuberg; Alexei Protopopov; Stephen E Sallan; Takaomi Sanda; Lewis B Silverman; Stuart S Winter; Shan Zha; Jianhua Zhang; A Thomas Look
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Blood 2011;118(15):4169-73.
2011: L A Rudner; Joshua Schiffman; A C H Smith; Nikolaus S Trede; D F Bradley; K H Brown; K P Dobrinski; J M Downie; J R Downing; M I Garcia; A Gutierrez; C Lee; A Thomas Look; N D Meeker; Charles G Mullighan; J K Frazer
Shared acquired genomic changes in zebrafish and human T-ALL.
Oncogene 2011;30(41):4289-96.
2011: Cong Zhu; Matthew Buffardi; Daniel Cifuentes; Jonathan A Epstein; Antonio J Giraldez; Abirami Lakshmanan; Nathan D Lawson; A Thomas Look; Joseph McNulty; Xiangdong Meng; Arun Padmanabhan; Amy L Rayla; Jimann Shin; Arndt F Siekmann; Tom Smith; Scot A Wolfe
Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
Development (Cambridge, England) 2011;138(20):4555-64.
2011: A Michael Forrester; Clemens Grabher; Fui-Boon Kai; A Thomas Look; Eileen R McBride; Elspeth Payne; Märta H Vigerstad; Ellen R Boyd; Sahar I Da'as; Alexander Edgar; Jason N Berman
NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis.
British journal of haematology 2011;155(2):167-81.
2011: Alejandro Gutierrez; Elena Kozakewich; George D Demetri; Christopher D M Fletcher; Jonathan A Fletcher; Ruta Grebliunaite; Adrian Marino-Enriquez; Wen-Bin Ou; Antonio R Perez-Atayde; Chandrajit P Raut; Ewa Sicinska; Stefano Sioletic; Eric L Snyder; Andrew J Wagner; Yi-Xiang Zhang; A Thomas Look
Aberrant AKT activation drives well-differentiated liposarcoma.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16386-91.
2011: Ujwal J Pyati; Seth Carbonneau; Evisa Gjini; Feng Guo; Cicely Jette; David P Kelsell; Jeong-Soo Lee; A Thomas Look
p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis.
Developmental cell 2011;21(3):492-505.
2011: Elspeth M Payne; Jennifer Rhodes; Richard Stone; Hong Sun; Omar I Abdel-Wahab; Alan H Beggs; Niccolò Bolli; Finbarr E Cotter; Hanna T Gazda; Cyrus V Hedvat; John P Kanki; Arati Khanna-Gupta; Ross Levine; A Thomas Look
Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.
Blood 2011;118(4):903-15.
2011: Niccolò Bolli; Elspeth M Payne; Jennifer Rhodes; Evisa Gjini; Adam B Johnston; Feng Guo; Jeong-Soo Lee; Rodney A Stewart; John P Kanki; Aye T Chen; Yi Zhou; Leonard I Zon; A Thomas Look
cpsf1 is required for definitive HSC survival in zebrafish.
Blood 2011;117(15):3996-4007.
2011: Xiaoyu Li; Takaomi Sanda; A Thomas Look; Carl D Novina; Harald von Boehmer
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.
The Journal of experimental medicine 2011;208(4):663-75.
2011: Clemens Grabher; E M Payne; A B Johnston; N Bolli; E Lechman; J E Dick; John P Kanki; A Thomas Look
Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.
Leukemia 2011;25(3):506-14.
2011: Blaine W Robinson; Giuseppe Germano; Yuanquan Song; Joshua Abrams; Marion Scott; Ilaria Guariento; Natascia Tiso; Francesco Argenton; Giuseppe Basso; Jennifer Rhodes; John P Kanki; A Thomas Look; Rita J Balice-Gordon; Carolyn A Felix
mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
British journal of haematology 2011;152(3):307-21.
2011: Julia Etchin; John P Kanki; A Thomas Look
Zebrafish as a model for the study of human cancer.
Methods in cell biology 2011;105():309-37.
2010: Jeong-Soo Lee; Arun Padmanabhan; Jimann Shin; Shizhen Zhu; Feng Guo; John P Kanki; Jonathan A Epstein; A Thomas Look
Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.
Human molecular genetics 2010;19(23):4643-53.
2010: Hui Feng; David L Stachura; Richard M White; Alejandro Gutierrez; Lu Zhang; Takaomi Sanda; Cicely A Jette; Joseph R Testa; Donna S Neuberg; David M Langenau; Jeffery L Kutok; Leonard I Zon; David Traver; Mark D Fleming; John P Kanki; A Thomas Look
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
Cancer cell 2010;18(4):353-66.
2010: David L Baker; Mary Lou Schmidt; Susan Cohn; John M Maris; Wendy B London; Allen Buxton; Daniel Stram; Robert P Castleberry; Hiroyuki Shimada; Anthony Sandler; Robert C Shamberger; A Thomas Look; Charles Patrick Reynolds; Robert C Seeger; Katherine K Matthay
Outcome after reduced chemotherapy for intermediate-risk neuroblastoma.
The New England journal of medicine 2010;363(14):1313-23.
2010: Alejandro Gutierrez; Suzanne E Dahlberg; Donna S Neuberg; Jianhua Zhang; Ruta Grebliunaite; Takaomi Sanda; Alexei Protopopov; Valeria Tosello; Jeffery L Kutok; Richard Larson; Michael J Borowitz; Mignon L Loh; Adolfo Ferrando; Stuart S Winter; Charles G Mullighan; Lewis B Silverman; Lynda Chin; Stephen P Hunger; Stephen E Sallan; A Thomas Look
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(24):3816-23.
2010: Kinuko Hirose; Takeshi Inukai; Jiro Kikuchi; Yusuke Furukawa; Tomokatsu Ikawa; Hiroshi Kawamoto; S Helen Oram; Berthold Göttgens; Nobutaka Kiyokawa; Yoshitaka Miyagawa; Hajime Okita; Koshi Akahane; Xiaochun Zhang; Itaru Kuroda; Hiroko Honna; Keiko Kagami; Kumiko Goi; Hidemitsu Kurosawa; A Thomas Look; Hirotaka Matsui; Toshiya Inaba; Kanji Sugita
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 2010;116(6):962-70.
2010: Shan Zha; Craig H Bassing; Takaomi Sanda; James W Brush; Harin Patel; Peter H Goff; Michael M Murphy; Suprawee Tepsuporn; Richard A Gatti; A Thomas Look; Frederick W Alt
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
The Journal of experimental medicine 2010;207(7):1369-80.
2010: Lijian Shao; Yan Sun; Zhonghui Zhang; Wei Feng; Yongxing Gao; Zailong Cai; Zack Z Wang; A Thomas Look; Wen-Shu Wu
Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.
Blood 2010;115(23):4707-14.
2010: Stefan Heinrichs; Cheng Li; A Thomas Look
SNP array analysis in hematologic malignancies: avoiding false discoveries.
Blood 2010;115(21):4157-61.
2010: Rodney A Stewart; Takaomi Sanda; Hans R Widlund; Shizhen Zhu; Kenneth D Swanson; Aeron D Hurley; Mohamed Bentires-Alj; David E Fisher; Maria I Kontaridis; A Thomas Look; Benjamin G Neel
Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
Developmental cell 2010;18(5):750-62.
2010: Alejandro Gutierrez; Takaomi Sanda; Wenxue Ma; Jianhua Zhang; Ruta Grebliunaite; Suzanne Dahlberg; Donna Neuberg; Alexei Protopopov; Stuart S Winter; Richard Larson; Michael J Borowitz; Lewis B Silverman; Lynda Chin; Stephen P Hunger; Catriona Jamieson; Stephen E Sallan; A Thomas Look
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
Blood 2010;115(14):2845-51.
2010: Takaomi Sanda; Xiaoyu Li; Alejandro Gutierrez; Yebin Ahn; Donna S Neuberg; Jennifer O'Neil; Peter R Strack; Christopher G Winter; Stuart S Winter; Richard Larson; Harald von Boehmer; A Thomas Look
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.
Blood 2010;115(9):1735-45.
2010: Mayuko Okuya; Hidemitsu Kurosawa; Jiro Kikuchi; Yusuke Furukawa; Hirotaka Matsui; Daisuke Aki; Takayuki Matsunaga; Takeshi Inukai; Hiroaki Goto; Rachel A Altura; Kenich Sugita; Osamu Arisaka; A Thomas Look; Toshiya Inaba
Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.
The Journal of biological chemistry 2010;285(3):1850-60.
2010: Rodney A Stewart; Jeong-Soo Lee; Martina Lachnit; A Thomas Look; John P Kanki; Paul D Henion
Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish.
Methods in cell biology 2010;100():127-52.
2009: Arun Padmanabhan; Jeong-Soo Lee; Fraz A Ismat; Min Min Lu; Nathan D Lawson; John P Kanki; A Thomas Look; Jonathan A Epstein
Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22305-10.
2009: Shintaro Kamizono; Gordon S Duncan; Markus G Seidel; Akira Morimoto; Koichi Hamada; Gerard Grosveld; Koichi Akashi; Evan F Lind; Jillian P Haight; Pamela S Ohashi; A Thomas Look; Tak W Mak
Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.
The Journal of experimental medicine 2009;206(13):2977-86.
2009: Jennifer Rhodes; Adam Amsterdam; Takaomi Sanda; Lisa A Moreau; Keith McKenna; Stefan Heinrichs; Neil J Ganem; Karen W Ho; Donna S Neuberg; Adam Johnston; Yebin Ahn; Jeffery L Kutok; Robert Hromas; Justin Wray; Charles Lee; Carly Murphy; Ina Radtke; James R Downing; Mark D Fleming; Laura E MacConaill; James F Amatruda; Alejandro Gutierrez; Ilene Galinsky; Richard M Stone; Eric A Ross; David S Pellman; John P Kanki; A Thomas Look
Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.
Molecular and cellular biology 2009;29(21):5911-22.
2009: Chizuko Okamatsu; Wendy B London; Arlene Naranjo; Michael D Hogarty; Julie M Gastier-Foster; A Thomas Look; Michael P LaQuaglia; John M Maris; Susan Cohn; Katherine K Matthay; Robert C Seeger; Tsutomu Saji; Hiroyuki Shimada
Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.
Pediatric blood & cancer 2009;53(4):563-9.
2009: S Heinrichs; R V Kulkarni; C E Bueso-Ramos; Ross Levine; Mignon L Loh; Cheng Li; Donna Neuberg; Steven M Kornblau; Jean-Pierre J Issa; D Gary Gilliland; G Garcia-Manero; H M Kantarjian; Elihu H Estey; A Thomas Look
Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.
Leukemia 2009;23(9):1605-13.
2009: M Ernest Dodd; Julia Hatzold; Jonathan R Mathias; Kevin B Walters; David A Bennin; Jennifer Rhodes; John P Kanki; A Thomas Look; Matthias Hammerschmidt; Anna Huttenlocher
The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.
Development (Cambridge, England) 2009;136(15):2591-600.
2009: Alejandro Gutierrez; Takaomi Sanda; Ruta Grebliunaite; Arkaitz Carracedo; Leonardo Salmena; Yebin Ahn; Suzanne Dahlberg; Donna Neuberg; Lisa A Moreau; Stuart S Winter; Richard Larson; Jianhua Zhang; Alexei Protopopov; Lynda Chin; Pier Paolo Pandolfi; Lewis B Silverman; Stephen P Hunger; Stephen E Sallan; A Thomas Look
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Blood 2009;114(3):647-50.
2009: Philipp Niethammer; Clemens Grabher; A Thomas Look; Timothy J Mitchison
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
Nature 2009;459(7249):996-9.
2009: Samuel Louis Volchenboum; Cheng Li; Shuli Li; Edward F Attiyeh; Charles Patrick Reynolds; John M Maris; A Thomas Look; Rani E George
Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis.
Cancer research 2009;69(10):4143-9.
2009: Sudhir S Rao; Jennifer O'Neil; Cole D Liberator; James S Hardwick; Xudong Dai; Theresa Zhang; Edyta Tyminski; Jing Yuan; Nancy E Kohl; Victoria M Richon; Lex H T Van Der Ploeg; Pamela M Carroll; Giulio F Draetta; A Thomas Look; Peter R Strack; Christopher G Winter
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
Cancer research 2009;69(7):3060-8.
2009: Thomas R Webb; Jake Slavish; Rani E George; A Thomas Look; Liquan Xue; Qin Jiang; Xiaoli Cui; Walter B Rentrop; Stephan W Morris
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.
Expert review of anticancer therapy 2009;9(3):331-56.
2009: Clark C Chen; Richard D Kennedy; Samuel Sidi; A Thomas Look; Alan D'Andrea
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors.
Molecular cancer 2009;8():24.
2009: Kevin B Walters; M Ernest Dodd; Jonathan R Mathias; Andrea J Gallagher; David A Bennin; Jennifer Rhodes; John P Kanki; A Thomas Look; Yevgenya Grinblat; Anna Huttenlocher
Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(1):86-99.
2008: Rani E George; Takaomi Sanda; Megan Hanna; Stefan Fröhling; William Luther; Jianming Zhang; Yebin Ahn; Wenjun Zhou; Wendy B London; Patrick McGrady; Liquan Xue; Sergey Zozulya; Vlad E Gregor; Thomas R Webb; Nathanael S Gray; D Gary Gilliland; Lisa Diller; Heidi Greulich; Stephan W Morris; Matthew Meyerson; A Thomas Look
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Nature 2008;455(7215):975-8.
2008: Yong Zhang; Xue-Tao Bai; Kang-Yong Zhu; Yi Jin; Min Deng; Huang-Ying Le; Yan-Fang Fu; Yi Chen; Jiang Zhu; A Thomas Look; John Kanki; Zhu Chen; Sai-Juan Chen; Ting Xi Liu
In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2155-64.
2008: David M Langenau; M D Keefe; N Y Storer; Cicely Jette; A C H Smith; C J Ceol; C Bourque; A Thomas Look; Leonard I Zon
Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.
Oncogene 2008;27(30):4242-8.
2008: Samuel Sidi; Takaomi Sanda; Richard D Kennedy; Andreas T Hagen; Cicely Jette; Raymond Hoffmans; Jennifer Pascual; Shintaro Imamura; Shuji Kishi; James F Amatruda; John P Kanki; Douglas R Green; Alan D D'Andrea; A Thomas Look
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Cell 2008;133(5):864-77.
2008: Woo Jae Kim; Ross A Okimoto; Louise E Purton; Meagan Goodwin; Sara M Haserlat; Farshid Dayyani; David A Sweetser; Andrea I McClatchey; Olivier A Bernard; A Thomas Look; Daphne W Bell; David T Scadden; Daniel A Haber
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Blood 2008;111(9):4716-22.
2008: Suzanne Schlisio; Rajappa S Kenchappa; Liesbeth C W Vredeveld; Rani E George; Rodney A Stewart; Heidi Greulich; Kristina Shahriari; Nguyen V Nguyen; Pascal Pigny; Patricia Dahia; Scott L Pomeroy; John M Maris; A Thomas Look; Matthew Meyerson; Daniel S Peeper; Bruce D Carter; William G Kaelin
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
Genes & development 2008;22(7):884-93.
2008: Ching-Hon Pui; Leslie L Robison; A Thomas Look
Acute lymphoblastic leukaemia.
Lancet 2008;371(9617):1030-43.
2008: Kenneth D Swanson; Jordan M Winter; Marcelo Reis; Mohamed Bentires-Alj; Heidi Greulich; Rupinder Grewal; Ralph Hruban; Charles J Yeo; Yosuf Yassin; Oleg Iartchouk; Kate Montgomery; Susan P Whitman; Michael A Caligiuri; Mignon L Loh; D Gary Gilliland; A Thomas Look; Raju Kucherlapati; Scott E Kern; Matthew Meyerson; Benjamin G Neel
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Genes, chromosomes & cancer 2008;47(3):253-9.
2008: Jennifer Schneiderman; Wendy B London; Garrett M Brodeur; Robert P Castleberry; A Thomas Look; Susan Cohn
Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(6):913-8.
2007: Jennifer O'Neil; Joëlle Tchinda; Alejandro Gutierrez; Lisa A Moreau; richard s maser; Kwok-Kin Wong; Wei Li; Keith McKenna; Xiaole (Shirley) Liu; Bin Feng; Donna Neuberg; Lewis B Silverman; Daniel J DeAngelo; Jeffery L Kutok; Rodney Rothstein; Ronald A DePinho; Lynda Chin; Charles Lee; A Thomas Look
Alu elements mediate MYB gene tandem duplication in human T-ALL.
The Journal of experimental medicine 2007;204(13):3059-66.
2007: Loen M Hansford; Amy E McKee; Libo Zhang; Rani E George; J Ted Gerstle; Paul S Thorner; Kristen M Smith; A Thomas Look; Herman Yeger; Freda D Miller; Meredith S. Irwin; Carol Jeanne Thiele; David R Kaplan
Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.
Cancer research 2007;67(23):11234-43.
2007: Alejandro Gutierrez; A Thomas Look
NOTCH and PI3K-AKT pathways intertwined.
Cancer cell 2007;12(5):411-3.
2007: Jennifer O'Neil; A Thomas Look
Mechanisms of transcription factor deregulation in lymphoid cell transformation.
Oncogene 2007;26(47):6838-49.
2007: Jonathan R Mathias; M Ernest Dodd; Kevin B Walters; Jennifer Rhodes; John P Kanki; A Thomas Look; Anna Huttenlocher
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
Journal of cell science 2007;120(Pt 19):3372-83.
2007: Gromoslaw A Smolen; Benjamin J Schott; Rodney A Stewart; Sven Diederichs; Beth Muir; Heather Provencher; A Thomas Look; Dennis C Sgroi; Randall T Peterson; Daniel A Haber
A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.
Genes & development 2007;21(17):2131-6.
2007: Jennifer O'Neil; Jonathan Grim; Peter Strack; Sudhir Rao; Deanne Tibbitts; Christopher Winter; James Hardwick; Markus Welcker; Jules P P Meijerink; Rob Pieters; Giulio F Draetta; Rosalie C Pelz; Bruce E Clurman; A Thomas Look
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
The Journal of experimental medicine 2007;204(8):1813-24.
2007: Hui Feng; David M Langenau; Jennifer A Madge; Andre Quinkertz; Alejandro Gutierrez; Donna Neuberg; John P Kanki; A Thomas Look
Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.
British journal of haematology 2007;138(2):169-75.
2007: Zhuyan Guo; Marei Dose; Damian Kovalovsky; Rui Chang; Jennifer O'Neil; A Thomas Look; Harald von Boehmer; Khashayarsha Khazaie; Fotini Gounari
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.
Blood 2007;109(12):5463-72.
2007: Jason N Berman; A Thomas Look
Targeting transcription factors in acute leukemia in children.
Current drug targets 2007;8(6):727-37.
2007: Ujwal J Pyati; A Thomas Look; Matthias Hammerschmidt
Zebrafish as a powerful vertebrate model system for in vivo studies of cell death.
Seminars in cancer biology 2007;17(2):154-65.
2007: J Chen; Cicely Jette; John P Kanki; Jon C Aster; A Thomas Look; James D Griffin
NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Leukemia 2007;21(3):462-71.
2007: Huw D Lewis; Matthew Leveridge; Peter R Strack; Christine D Haldon; Jennifer O'Neil; Hellen Kim; Andrew Madin; Joanne C Hannam; A Thomas Look; Nancy Kohl; Giulio F Draetta; Timothy Harrison; Julie A Kerby; Mark S Shearman; Dirk Beher
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
Chemistry & biology 2007;14(2):209-19.
2007: Ting Xi Liu; Jennifer Rhodes; Min Deng; Karl Hsu; Hanna S Radomska; John P Kanki; Daniel G Tenen; A Thomas Look
Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
Experimental hematology 2007;35(2):230-9.
2007: Stefan Heinrichs; A Thomas Look
Identification of structural aberrations in cancer by SNP array analysis.
Genome biology 2007;8(7):219.
2007: Rani E George; Edward F Attiyeh; Shuli Li; Lisa A Moreau; Donna Neuberg; Cheng Li; Edward A Fox; Matthew Meyerson; Lisa Diller; Paolo Fortina; A Thomas Look; John M Maris
Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.
PloS one 2007;2(2):e255.
2007: Ting Xi Liu; Michael W Becker; Jaroslav Jelinek; Wen-Shu Wu; Min Deng; Natallia Mikhalkevich; Karl Hsu; Clara D Bloomfield; Richard M Stone; Daniel J DeAngelo; Ilene Galinsky; Jean-Pierre J Issa; Michael F Clarke; A Thomas Look
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
Nature medicine 2007;13(1):78-83.
2006: Jonathan R Mathias; Benjamin J Perrin; Ting Xi Liu; John P Kanki; A Thomas Look; Anna Huttenlocher
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.
Journal of leukocyte biology 2006;80(6):1281-8.
2006: Teresa Palomero; Wei Keat Lim; Duncan T Odom; Maria Luisa Sulis; Pedro J Real; Adam A Margolin; Kelly C Barnes; Jennifer O'Neil; Donna Neuberg; Andrew P Weng; Jon C Aster; François Sigaux; Jean Soulier; A Thomas Look; Richard A Young; Andrea Califano; Adolfo Ferrando
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18261-6.
2006: Teresa Palomero; K McKenna; J O-Neil; Ilene Galinsky; R Stone; K Suzukawa; E Stiakaki; M Kalmanti; Edward A Fox; M A Caligiuri; Jon C Aster; A Thomas Look; Adolfo Ferrando
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.
Leukemia 2006;20(11):1963-6.
2006: Lisa A Moreau; Patrick McGrady; Wendy B London; Hiroyuki Shimada; Susan Cohn; John M Maris; Lisa Diller; A Thomas Look; Rani E George
Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5693-7.
2006: Teresa Palomero; Duncan T Odom; Jennifer O'Neil; Adolfo Ferrando; Adam A Margolin; Donna Neuberg; Stuart S Winter; Richard Larson; Wei Li; Xiaole (Shirley) Liu; Richard A Young; A Thomas Look
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.
Blood 2006;108(3):986-92.
2006: Clemens Grabher; Harald von Boehmer; A Thomas Look
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
Nature reviews. Cancer 2006;6(5):347-59.
2006: Rodney A Stewart; Brigitte L Arduini; Stephane Berghmans; Rani E George; John P Kanki; Paul D Henion; A Thomas Look
Zebrafish foxd3 is selectively required for neural crest specification, migration and survival.
Developmental biology 2006;292(1):174-88.
2006: Jennifer O'Neil; Jennifer Calvo; Keith McKenna; Veena Krishnamoorthy; Jon C Aster; Craig H Bassing; Frederick W Alt; Michelle A Kelliher; A Thomas Look
Activating Notch1 mutations in mouse models of T-ALL.
Blood 2006;107(2):781-5.
2006: Clemens Grabher; A Thomas Look
Fishing for cancer models.
Nature biotechnology 2006;24(1):45-6.
2005: Samuel Sidi; A Thomas Look
Small molecules thwart crash and burn.
Nature chemical biology 2005;1(7):351-3.
2005: Rochelle Bagatell; Pavlina Rumcheva; Wendy B London; Susan Cohn; A Thomas Look; Garrett M Brodeur; Christopher Frantz; Vijay Joshi; Paul Thorner; P V Rao; Robert P Castleberry; Laura C Bowman
Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(34):8819-27.
2005: Edward F Attiyeh; Wendy B London; Yael P Mossé; Qun Wang; Cynthia Winter; Deepa Khazi; Patrick W McGrady; Robert C Seeger; A Thomas Look; Hiroyuki Shimada; Garrett M Brodeur; Susan Cohn; Katherine K Matthay; John M Maris
Chromosome 1p and 11q deletions and outcome in neuroblastoma.
The New England journal of medicine 2005;353(21):2243-53.
2005: Wen-Shu Wu; Stefan Heinrichs; Dong Xu; Sean P Garrison; Gerard P Zambetti; Jerry M Adams; A Thomas Look
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma.
Cell 2005;123(4):641-53.
2005: Ross Levine; Marc Loriaux; Brian J P Huntly; Mignon L Loh; Miroslav Beran; Eric P Stoffregen; Roland Berger; Jennifer J Clark; Stephanie G Willis; Kim T Nguyen; Nikki J Flores; Elihu Estey; Norbert Gattermann; Scott A Armstrong; A Thomas Look; James D Griffin; Olivier A Bernard; Michael C Heinrich; D Gary Gilliland; Brian J Druker; Michael W N Deininger
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
Blood 2005;106(10):3377-9.
2005: Nyla A Heerema; Alain BERNHEIM; Megan S Lim; A Thomas Look; Laura Pasqualucci; Elizabeth A Raetz; Warren G Sanger; Mitchell S Cairo
State of the Art and Future Needs in Cytogenetic/Molecular Genetics/Arrays in childhood lymphoma: summary report of workshop at the First International Symposium on childhood and adolescent non-Hodgkin lymphoma, April 9, 2003, New York City, NY.
Pediatric blood & cancer 2005;45(5):616-22.
2005: Wendy B London; Robert P Castleberry; K K Matthay; A Thomas Look; Robert C Seeger; H Shimada; Paul Thorner; Garrett M Brodeur; John M Maris; Charles Patrick Reynolds; Susan Cohn
Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(27):6459-65.
2005: Rani E George; Wendy B London; Susan Cohn; John M Maris; Cynthia S Kretschmar; Lisa Diller; Garrett M Brodeur; Robert P Castleberry; A Thomas Look
Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(27):6466-73.
2005: Scott A Armstrong; A Thomas Look
Molecular genetics of acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(26):6306-15.
2005: Jason N Berman; John P Kanki; A Thomas Look
Zebrafish as a model for myelopoiesis during embryogenesis.
Experimental hematology 2005;33(9):997-1006.
2005: Stefan Heinrichs; Jason N Berman; Taylor M Ortiz; Steven M Kornblau; Donna Neuberg; Elihu H Estey; A Thomas Look
CD34+ cell selection is required to assess HOXA9 expression levels in patients with myelodysplastic syndrome.
British journal of haematology 2005;130(1):83-6.
2005: Takeshi Inukai; Toshiya Inaba; Jinjun Dang; Ryoko Kuribara; Keiya Ozawa; Atsushi Miyajima; Wenshu Wu; A Thomas Look; Yojiro Arinobu; Hiromi Iwasaki; Koichi Akashi; Keiko Kagami; Kumiko Goi; Kanji Sugita; Shinpei Nakazawa
TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.
Blood 2005;105(11):4437-44.
2005: David M Langenau; Hui Feng; Stephane Berghmans; John P Kanki; Jeffery L Kutok; A Thomas Look
Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6068-73.
2005: David M Langenau; Cicely Jette; Stephane Berghmans; Teresa Palomero; John P Kanki; Jeffery L Kutok; A Thomas Look
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.
Blood 2005;105(8):3278-85.
2005: Malay Mandal; Christine Borowski; Teresa Palomero; Adolfo Ferrando; Philipp Oberdoerffer; Fanyong Meng; Antonio Ruiz-Vela; Maria Ciofani; Juan Carlos Zuniga-Pflucker; Isabella Screpanti; A Thomas Look; Stanley J Korsmeyer; Klaus Rajewsky; Harald von Boehmer; Ioannis Aifantis
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
The Journal of experimental medicine 2005;201(4):603-14.
2005: E Elizabeth Patton; Hans R Widlund; Jeffery L Kutok; Kamden R Kopani; James F Amatruda; Ryan D Murphey; Stephane Berghmans; Elizabeth A Mayhall; David Traver; Christopher D M Fletcher; Jon C Aster; Scott R Granter; A Thomas Look; Charles Lee; David E Fisher; Leonard I Zon
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
Current biology : CB 2005;15(3):249-54.
2005: Stephane Berghmans; Ryan D Murphey; Erno Wienholds; Donna Neuberg; Jeffery L Kutok; Christopher D M Fletcher; John P Morris; Ting Xi Liu; Stefan Schulte-Merker; John P Kanki; Ronald H Plasterk; Leonard I Zon; A Thomas Look
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):407-12.
2005: A Thomas Look
Molecular Pathogenesis of MDS.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005;():156-60.
2005: Jennifer Rhodes; Andreas Hagen; Karl Hsu; Min Deng; Ting Xi Liu; A Thomas Look; John P Kanki
Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.
Developmental cell 2005;8(1):97-108.
2004: A Thomas Look
Molecular pathways in T-cell acute lympho-blastic leukemia: ramifications for therapy.
Clinical advances in hematology & oncology : H&O 2004;2(12):779-80.
2004: Adolfo Ferrando; A Thomas Look
DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia.
International journal of hematology 2004;80(5):395-400.
2004: Huai-Dong Song; Xiao-Jian Sun; Min Deng; Guo-Wei Zhang; Yi Zhou; Xin-Yan Wu; Yan Sheng; Yi Chen; Zheng Ruan; Chun-Lei Jiang; Hui-Yong Fan; Leonard I Zon; John P Kanki; Ting Xi Liu; A Thomas Look; Zhu Chen
Hematopoietic gene expression profile in zebrafish kidney marrow.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(46):16240-5.
2004: hongwei yang; Jeffery L Kutok; Nam Hyuk Lee; Hui Ying Piao; Christopher D M Fletcher; John P Kanki; A Thomas Look
Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish.
Cancer research 2004;64(20):7256-62.
2004: Andrew P Weng; Adolfo Ferrando; Woojoong Lee; John P Morris; Lewis B Silverman; Cheryll Sanchez-Irizarry; Stephen C Blacklow; A Thomas Look; Jon C Aster
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science (New York, N.Y.) 2004;306(5694):269-71.
2004: David Traver; Alissa Winzeler; Howard M Stern; Elizabeth A Mayhall; David M Langenau; Jeffery L Kutok; A Thomas Look; Leonard I Zon
Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.
Blood 2004;104(5):1298-305.
2004: Karl Hsu; David Traver; Jeffery L Kutok; Andreas Hagen; Ting Xi Liu; Barry H Paw; Jennifer Rhodes; Jason N Berman; Leonard I Zon; John P Kanki; A Thomas Look
The pu.1 promoter drives myeloid gene expression in zebrafish.
Blood 2004;104(5):1291-7.
2004: Elisabeth Paietta; Adolfo Ferrando; Donna Neuberg; John M Bennett; Janis Racevskis; Hillard Lazarus; Gordon Dewald; Jacob M Rowe; Peter H Wiernik; Martin S Tallman; A Thomas Look
Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
Blood 2004;104(2):558-60.
2004: David M Langenau; Adolfo Ferrando; David Traver; Jeffery L Kutok; John-Paul D Hezel; John P Kanki; Leonard I Zon; A Thomas Look; Nikolaus S Trede
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(19):7369-74.
2004: Takayuki Matsunaga; Toshiya Inaba; Hirotaka Matsui; Mayuko Okuya; Atsushi Miyajima; Takeshi Inukai; Tetsunori Funabiki; Mikiya Endo; A Thomas Look; Hidemitsu Kurosawa
Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.
Blood 2004;103(8):3185-91.
2004: Nikolaus S Trede; David M Langenau; David Traver; A Thomas Look; Leonard I Zon
The use of zebrafish to understand immunity.
Immunity 2004;20(4):367-79.
2004: Joao T Barata; Vassiliki A Boussiotis; Jose A Yunes; Adolfo Ferrando; Lisa A Moreau; J Pedro Veiga; Stephen E Sallan; A Thomas Look; Lee M Nadler; Angelo A Cardoso
IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.
Blood 2004;103(5):1891-900.
2004: Adolfo Ferrando; Sabine Herblot; Teresa Palomero; Mark Hansen; Trang Hoang; Edward A Fox; A Thomas Look
Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
Blood 2004;103(5):1909-11.
2004: Adolfo Ferrando; Donna Neuberg; Richard K Dodge; Elisabeth Paietta; Richard A Larson; Peter H Wiernik; Jacob M Rowe; Michael A Caligiuri; Clara D Bloomfield; A Thomas Look
Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.
Lancet 2004;363(9408):535-6.
2004: Stephane Berghmans; John P Morris; John P Kanki; A Thomas Look
Zebrafish sperm cryopreservation.
Methods in cell biology 2004;77():645-59.
2004: Karl Hsu; A Thomas Look; John P Kanki
Lessons from transgenic zebrafish expressing the green fluorescent protein (GFP) in the myeloid lineage.
Methods in cell biology 2004;77():333-47.
2004: Rodney A Stewart; A Thomas Look; John P Kanki; Paul D Henion
Development of the peripheral sympathetic nervous system in zebrafish.
Methods in cell biology 2004;76():237-60.
2003: Ting Xi Liu; Niall G Howlett; Min Deng; David M Langenau; Karl Hsu; Jennifer Rhodes; John P Kanki; Alan D D'Andrea; A Thomas Look
Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.
Developmental cell 2003;5(6):903-14.
2003: John P Morris; Stephane Berghmans; David Zahrieh; Donna Neuberg; John P Kanki; A Thomas Look
Zebrafish sperm cryopreservation with N,N-dimethylacetamide.
BioTechniques 2003;35(5):956-8, 960, 962 passim.
2003: Jason Berman; Karl Hsu; A Thomas Look
Zebrafish as a model organism for blood diseases.
British journal of haematology 2003;123(4):568-76.
2003: Adolfo Ferrando; A Thomas Look
Gene expression profiling in T-cell acute lymphoblastic leukemia.
Seminars in hematology 2003;40(4):274-80.
2003: Karl Hsu; A Thomas Look
Turning on a dimer: new insights into MLL chimeras.
Cancer cell 2003;4(2):81-3.
2003: Adolfo Ferrando; Scott A Armstrong; Donna Neuberg; Stephen E Sallan; Lewis B Silverman; Stanley J Korsmeyer; A Thomas Look
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
Blood 2003;102(1):262-8.
2003: David M Langenau; David Traver; Adolfo Ferrando; Jeffery L Kutok; Jon C Aster; John P Kanki; Shuo Lin; Ed Prochownik; Nikolaus S Trede; Leonard I Zon; A Thomas Look
Myc-induced T cell leukemia in transgenic zebrafish.
Science (New York, N.Y.) 2003;299(5608):887-90.
2002: Michael D Hogarty; Cynthia L Winter; Xueyuan Liu; Chun Guo; Peter White; A Thomas Look; Garrett M Brodeur; John M Maris
No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.
Cancer research 2002;62(22):6481-4.
2002: Akira Inoue; Markus G Seidel; Wenshu Wu; Shintaro Kamizono; Adolfo Ferrando; Roderick T Bronson; Hiromi Iwasaki; Koichi Akashi; akira morimoto; Johann K Hitzler; Tamara I Pestina; Carl W Jackson; Ryuhei Tanaka; Miriam J Chong; Peter J McKinnon; Takeshi Inukai; Gerard C Grosveld; A Thomas Look
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.
Cancer cell 2002;2(4):279-88.
2002: David M Langenau; Teresa Palomero; John P Kanki; Adolfo Ferrando; Y Zhou; Leonard I Zon; A Thomas Look
Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).
Mechanisms of development 2002;117(1-2):243-8.
2002: A Thomas Look
A leukemogenic twist for GATA1.
Nature genetics 2002;32(1):83-4.
2002: Ting Xi Liu; Yi Zhou; John P Kanki; Min Deng; Jennifer Rhodes; hongwei yang; Xiao Ming Sheng; Leonard I Zon; A Thomas Look
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6136-41.
2002: Adolfo Ferrando; Donna Neuberg; Jane Staunton; Mignon L Loh; Christine Huard; Susana C Raimondi; Frederick G. Behm; Ching-Hon Pui; James R Downing; D Gary Gilliland; Eric S Lander; Todd R Golub; A Thomas Look
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Cancer cell 2002;1(1):75-87.
2001: M G Seidel; A Thomas Look
E2A-HLF usurps control of evolutionarily conserved survival pathways.
Oncogene 2001;20(40):5718-25.
2001: Jinjun Dang; Takeshi Inukai; H Kurosawa; Kumiko Goi; Toshiya Inaba; Noel Lenny; J R Downing; Stefano Stifani; A Thomas Look
The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.
Molecular and cellular biology 2001;21(17):5935-45.
2001: C M Bennett; John P Kanki; Jennifer Rhodes; Ting Xi Liu; Barry H Paw; Mark W Kieran; David M Langenau; A Delahaye-Brown; Leonard I Zon; Mark D Fleming; A Thomas Look
Myelopoiesis in the zebrafish, Danio rerio.
Blood 2001;98(3):643-51.
2001: Karl Hsu; John P Kanki; A Thomas Look
Zebrafish myelopoiesis and blood cell development.
Current opinion in hematology 2001;8(4):245-51.
2001: Prasad Mathew; Marcus B Valentine; Laura C Bowman; ST Rowe; MB Nash; Virginia Valentine; Susan Cohn; Robert P Castleberry; Garrett M Brodeur; A Thomas Look
Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study.
Neoplasia (New York, N.Y.) 2001;3(2):105-9.
2001: Garrett M Brodeur; A Thomas Look; H Shimada; V M Hamilton; John M Maris; H W Hann; Jean-Marie Leclerc; Mark Bernstein; LC Brisson; Jean-Hugues Brossard; Bernard Lemieux; Mendel Tuchman; William G Woods
Biological aspects of neuroblastomas identified by mass screening in Quebec.
Medical and pediatric oncology 2001;36(1):157-9.
2000: Adolfo Ferrando; A Thomas Look
Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia.
Seminars in hematology 2000;37(4):381-95.
2000: CS Alvarado; Wendy B London; A Thomas Look; Garrett M Brodeur; D H Altmiller; Paul Thorner; Vijay V Joshi; ST Rowe; MB Nash; E Ide Smith; Robert P Castleberry; Susan Cohn
Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study.
Journal of pediatric hematology/oncology 2000;22(3):197-205.
2000: Tal Teitz; Tie Wei; Marcus B Valentine; E F Vanin; Jose Grenet; Virginia Valentine; Frederick G. Behm; A Thomas Look; Jill Lahti; Vincent J Kidd
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN.
Nature medicine 2000;6(5):529-35.
1999: Patricia Shearer; Marcus B Valentine; P Grundy; J M DeCou; S D Banavali; H Komuro; Daniel M Green; J Bruce Beckwith; A Thomas Look
Hemizygous deletions of chromosome band 16q24 in Wilms tumor: detection by fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1999;115(2):100-5.
1999: Takeshi Inukai; A Inoue; H Kurosawa; Kumiko Goi; T Shinjyo; K Ozawa; M Mao; Toshiya Inaba; A Thomas Look
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
Molecular cell 1999;4(3):343-52.
1999: H Komuro; Marcus B Valentine; J E Rubnitz; M Saito; Susana C Raimondi; A J Carroll; T Yi; C J Sherr; A Thomas Look
p27KIP1 deletions in childhood acute lymphoblastic leukemia.
Neoplasia (New York, N.Y.) 1999;1(3):253-61.
1999: Johann K Hitzler; D P Witte; N A Jenkins; N G Copeland; D J Gilbert; Clayton W Naeve; A Thomas Look; Stephan W Morris
cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia.
The American journal of pathology 1999;155(1):53-9.
1999: X T Kong; Virginia Valentine; ST Rowe; Marcus B Valentine; ST Ragsdale; B G Jones; D A Wilkinson; Garrett M Brodeur; Susan Cohn; A Thomas Look
Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines.
Neoplasia (New York, N.Y.) 1999;1(1):80-9.
1999: S M Bodner; Clayton W Naeve; Karen M Rakestraw; B G Jones; Virginia Valentine; Marcus B Valentine; Frederick W Luthardt; C L Willman; Susana C Raimondi; James R Downing; M F Roussel; C J Sherr; A Thomas Look
Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1).
Gene 1999;229(1-2):223-8.
1999: DA Reardon; RE Entrekin; JE Sublett; ST Ragsdale; H Li; James M Boyett; J L Kepner; A Thomas Look
Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma.
Genes, chromosomes & cancer 1999;24(3):230-7.
1999: Johann K Hitzler; HD Soares; D W Drolet; Toshiya Inaba; S O'Connel; James I Morgan; A Thomas Look
Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice.
Brain research 1999;820(1-2):1-11.
1999: H Kurosawa; Kumiko Goi; T Inukai; T Inaba; K S Chang; T Shinjyo; Karen M Rakestraw; Clayton W Naeve; A Thomas Look
Two candidate downstream target genes for E2A-HLF.
Blood 1999;93(1):321-32.
1998: Kim E Nichols; D P Harkin; S Levitz; michael krainer; KA Kolquist; C Genovese; A Bernard; M Ferguson; L Zuo; Eric Snyder; AJ Buckler; C Wise; J Ashley; Michael Lovett; M B Valentine; A Thomas Look; William Gerald; David E Housman; Daniel A Haber
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13765-70.
1998: H Komuro; Marcus B Valentine; ST Rowe; Vincent J Kidd; S Makino; Garrett M Brodeur; Susan Cohn; A Thomas Look
Fluorescence in situ hybridization analysis of chromosome 1p36 deletions in human MYCN amplified neuroblastoma.
Journal of pediatric surgery 1998;33(11):1695-8.
1998: Takeshi Inukai; Toshiya Inaba; S Ikushima; A Thomas Look
The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.
Molecular and cellular biology 1998;18(10):6035-43.
1998: R A Altura; T Inukai; RA Ashmun; G P Zambetti; Martine F Roussel; A Thomas Look
The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells.
Blood 1998;92(4):1397-405.
1998: Jeffrey E Rubnitz; A Thomas Look
Molecular basis of leukemogenesis.
Current opinion in hematology 1998;5(4):264-70.
1998: Howard M Katzenstein; Laura C Bowman; Garrett M Brodeur; Paul Thorner; Vijay V Joshi; E Ide Smith; A Thomas Look; ST Rowe; MB Nash; T Holbrook; C Alvarado; P V Rao; Robert P Castleberry; Susan Cohn
Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: the pediatric oncology group experience--a pediatric oncology group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(6):2007-17.
1998: JE Sublett; RE Entrekin; A Thomas Look; DA Reardon
Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping.
Genomics 1998;50(1):112-4.
1998: Jeffrey E Rubnitz; A Thomas Look
Molecular genetics of childhood leukemias.
Journal of pediatric hematology/oncology 1998;20(1):1-11.
1997: A Thomas Look
Oncogenic transcription factors in the human acute leukemias.
Science (New York, N.Y.) 1997;278(5340):1059-64.
1997: Martin U Kuefer; A Thomas Look; Karen Pulford; Frederick G. Behm; P K Pattengale; David Y Mason; Stephan W Morris
Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice.
Blood 1997;90(8):2901-10.
1997: DA Reardon; Edson Michalkiewicz; James M Boyett; JE Sublett; RE Entrekin; ST Ragsdale; Marcus B Valentine; Frederick G. Behm; H Li; Richard L Heideman; Larry E Kun; DN Shapiro; A Thomas Look
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.
Cancer research 1997;57(18):4042-7.
1997: R A Altura; John M Maris; H Li; J M Boyett; Garrett M Brodeur; A Thomas Look
Novel regions of chromosomal loss in familial neuroblastoma by comparative genomic hybridization.
Genes, chromosomes & cancer 1997;19(3):176-84.
1997: S Ikushima; Takeshi Inukai; Toshiya Inaba; Stephen D Nimer; J L Cleveland; A Thomas Look
Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2609-14.
1997: X Gong; Sunjay Kaushal; E Ceccarelli; N Bogdanova; C Neville; T Nguyen; H Clark; Z A Khatib; M Valentine; A Thomas Look; Nadia Rosenthal
Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family.
Developmental biology 1997;183(2):166-82.
1997: Laura C Bowman; Robert P Castleberry; A Cantor; Vijay Joshi; Susan Cohn; E Ide Smith; Alice L Yu; Garrett M Brodeur; F A Hayes; A Thomas Look
Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Journal of the National Cancer Institute 1997;89(5):373-80.
1997: Takeshi Inukai; Toshiya Inaba; T Yoshihara; A Thomas Look
Cell transformation mediated by homodimeric E2A-HLF transcription factors.
Molecular and cellular biology 1997;17(3):1417-24.
1997: A Thomas Look
E2A-HLF chimeric transcription factors in pro-B cell acute lymphoblastic leukemia.
Current topics in microbiology and immunology 1997;220():45-53.
1996: R A Altura; M Valentine; H Li; J M Boyett; Patricia Shearer; P Grundy; DN Shapiro; A Thomas Look
Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization.
Cancer research 1996;56(16):3837-41.
1996: T Inaba; T Inukai; T Yoshihara; H Seyschab; R A Ashmun; Shilpy Sharma; S J Laken; Michael B Kastan; A Thomas Look
Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
Nature 1996;382(6591):541-4.
1996: M U Kuefer; A Thomas Look; D C Williams; Virginia Valentine; Clayton W Naeve; Frederick G. Behm; J E Mullersman; N Yoneda-Kato; K Montgomery; R Kucherlapati; Stephan W Morris
cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2).
Genomics 1996;35(2):392-6.
1996: H Li; Jill Lahti; M Valentine; M Saito; S I Reed; A Thomas Look; Vincent J Kidd
Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors.
Genomics 1996;32(2):253-9.
1996: N Yoneda-Kato; A Thomas Look; M N Kirstein; Marcus B Valentine; Susana C Raimondi; K J Cohen; A J Carroll; Stephan W Morris
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
Oncogene 1996;12(2):265-75.
1995: M Saito; M Kumagai; T Okazaki; S Nakazawa; Linda H. Shapiro; A Thomas Look; D Campana
Stromal cell-mediated transcriptional regulation of the CD13/aminopeptidase N gene in leukemic cells.
Leukemia 1995;9(9):1508-16.
1995: A Thomas Look
Fusion genes and their hybrid proteins in human leukemias and lymphomas.
Proceedings of the Association of American Physicians 1995;107(2):175-80.
1995: T Yoshihara; Toshiya Inaba; Linda H. Shapiro; J Y Kato; A Thomas Look
E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.
Molecular and cellular biology 1995;15(6):3247-55.
1995: Susan Cohn; A Thomas Look; Vijay V Joshi; T Holbrook; Helen R Salwen; D Chagnovich; L Chesler; ST Rowe; Marcus B Valentine; H Komuro
Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: a Pediatric Oncology Group study.
Cancer research 1995;55(4):721-6.
1995: J A Morris; S J Shcochat; E Ide Smith; A Thomas Look; Garrett M Brodeur; A B Cantor; Robert P Castleberry
Biological variables in thoracic neuroblastoma: a Pediatric Oncology Group study.
Journal of pediatric surgery 1995;30(2):296-302; discussion 302-3.
1995: Stephan W Morris; M N Kirstein; Marcus B Valentine; K Dittmer; DN Shapiro; A Thomas Look; D L Saltman
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
Science (New York, N.Y.) 1995;267(5196):316-7.
1995: A Thomas Look
Oncogenic role of "master" transcription factors in human leukemias and sarcomas: a developmental model.
Advances in cancer research 1995;67():25-57.
1995: M Saito; K Helin; Marcus B Valentine; B B Griffith; Cheryl L Willman; E Harlow; A Thomas Look
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.
Genomics 1995;25(1):130-8.
1994: Z A Khatib; Toshiya Inaba; M Valentine; A Thomas Look
Chromosomal localization and cDNA cloning of the human DBP and TEF genes.
Genomics 1994;23(2):344-51.
1994: Jill Lahti; M Valentine; J Xiang; B Jones; J Amann; Jose Grenet; G Richmond; A Thomas Look; Vincent J Kidd
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.
Nature genetics 1994;7(3):370-5.
1994: Toshiya Inaba; Linda H. Shapiro; T Funabiki; A E Sinclair; B G Jones; RA Ashmun; A Thomas Look
DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
Molecular and cellular biology 1994;14(5):3403-13.
1994: Stephan W Morris; M N Kirstein; Marcus B Valentine; K G Dittmer; DN Shapiro; D L Saltman; A Thomas Look
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
Science (New York, N.Y.) 1994;263(5151):1281-4.
1994: K W Jolly; David Malkin; E C Douglass; T F Brown; A E Sinclair; A Thomas Look
Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer.
Oncogene 1994;9(1):97-102.
1993: M Koehler; Frederick G. Behm; J Shuster; William M Crist; Michael J Borowitz; A Thomas Look; D Head; Andrew J Carroll; Vita J Land; P Steuber
Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study.
Leukemia 1993;7(12):2064-8.
1993: Z A Khatib; H Matsushime; M Valentine; DN Shapiro; Charles J Sherr; A Thomas Look
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.
Cancer research 1993;53(22):5535-41.
1993: Amar Gajjar; Richard L Heideman; E C Douglass; Larry E Kun; E H Kovnar; Robert A Sanford; D L Fairclough; D Ayers; A Thomas Look
Relation of tumor-cell ploidy to survival in children with medulloblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(11):2211-7.
1993: Ching-Hon Pui; Michael L Hancock; D R Head; Jaime Rivera; A Thomas Look; John T Sandlund; Frederick G. Behm
Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia.
Blood 1993;82(3):889-94.
1993: Vijay V Joshi; A B Cantor; Garrett M Brodeur; A Thomas Look; Jonathan J Shuster; G Altshuler; E W Larkin; C T Holbrook; Jan F Silverman; H T Norris
Correlation between morphologic and other prognostic markers of neuroblastoma. A study of histologic grade, DNA index, N-myc gene copy number, and lactic dehydrogenase in patients in the Pediatric Oncology Group.
Cancer 1993;71(10):3173-81.
1993: DN Shapiro; Marcus B Valentine; ST Rowe; A E Sinclair; JE Sublett; W M Roberts; A Thomas Look
Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma.
The American journal of pathology 1993;142(5):1339-46.
1993: Michael J Borowitz; Andrew J Carroll; Jonathan J Shuster; A Thomas Look; Frederick G. Behm; D Jeanette Pullen; Vita J Land; P Steuber; W M Crist
Use of clinical and laboratory features to define prognostic subgroups in B-precursor acute lymphoblastic leukemia: experience of the Pediatric Oncology Group.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;131():257-67.
1993: Kathryn V Holmes; Gabriela S Dveksler; S Gagneten; C Yeager; S H Lin; Nicole Beauchemin; A Thomas Look; RA Ashmun; Carl W Dieffenbach
Coronavirus receptor specificity.
Advances in experimental medicine and biology 1993;342():261-6.
1992: Stephan W Morris; N Nelson; Marcus B Valentine; DN Shapiro; A Thomas Look; Carl J Kozlosky; M P Beckmann; Douglas Pat Cerretti
Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.
Genomics 1992;14(3):685-91.
1992: Stephan W Morris; J T Foust; Marcus B Valentine; W M Roberts; DN Shapiro; A Thomas Look
Sublocalization of the chromosome 5 breakpoint of the 3;5 translocation in myelodysplastic syndromes and acute myeloid leukemia.
Genes, chromosomes & cancer 1992;5(4):385-91.
1992: Toshiya Inaba; W M Roberts; Linda H. Shapiro; K W Jolly; Susana C Raimondi; S D Smith; A Thomas Look
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
Science (New York, N.Y.) 1992;257(5069):531-4.
1992: Toshiya Inaba; H Matsushime; M Valentine; Martine F Roussel; Charles J Sherr; A Thomas Look
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.
Genomics 1992;13(3):565-74.
1992: RA Ashmun; Linda H. Shapiro; A Thomas Look
Deletion of the zinc-binding motif of CD13/aminopeptidase N molecules results in loss of epitopes that mediate binding of inhibitory antibodies.
Blood 1992;79(12):3344-9.
1992: C L Yeager; RA Ashmun; R K Williams; C B Cardellichio; Linda H. Shapiro; A Thomas Look; Kathryn V Holmes
Human aminopeptidase N is a receptor for human coronavirus 229E.
Nature 1992;357(6377):420-2.
1992: David Malkin; K W Jolly; N Barbier; A Thomas Look; S H Friend; M C Gebhardt; Tone Ikdal Andersen; A L Børresen; Frederick P Li; Judy E Garber
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
The New England journal of medicine 1992;326(20):1309-15.
1992: DN Shapiro; Marcus B Valentine; JE Sublett; A E Sinclair; A M Tereba; H Scheffer; C H Buys; A Thomas Look
Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma.
Genes, chromosomes & cancer 1992;4(3):241-9.
1992: Frederick G. Behm; Susana C Raimondi; Michael J Schell; A Thomas Look; Jaime Rivera; Ching-Hon Pui
Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features.
Blood 1992;79(4):1011-6.
1992: W M Roberts; Linda H. Shapiro; RA Ashmun; A Thomas Look
Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters.
Blood 1992;79(3):586-93.
1991: Stephan W Morris; Marcus B Valentine; DN Shapiro; JE Sublett; L L Deaven; J T Foust; W M Roberts; Douglas Pat Cerretti; A Thomas Look
Reassignment of the human CSF1 gene to chromosome 1p13-p21.
Blood 1991;78(8):2013-20.
1991: Linda H. Shapiro; RA Ashmun; W M Roberts; A Thomas Look
Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.
The Journal of biological chemistry 1991;266(18):11999-2007.
1991: A Thomas Look; F A Hayes; Jonathan J Shuster; E C Douglass; Robert P Castleberry; Laura C Bowman; E Ide Smith; Garrett M Brodeur
Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(4):581-91.
1991: Jaime Rivera; Susana C Raimondi; Michael L Hancock; Frederick G. Behm; Ching-Hon Pui; M Abromowitch; J Mirro; J S Ochs; A Thomas Look; D L Williams
Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy.
Lancet 1991;337(8733):61-6.
1991: DN Shapiro; David M Parham; E C Douglass; RA Ashmun; B L Webber; WA Newton; Michael L Hancock; Harold M Maurer; A Thomas Look
Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(1):159-66.
1990: Ching-Hon Pui; William M Crist; A Thomas Look
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
Blood 1990;76(8):1449-63.
1990: Michael J Borowitz; Jonathan J Shuster; Curt I Civin; Andrew J Carroll; A Thomas Look; Frederick G. Behm; Vita J Land; D Jeanette Pullen; W M Crist
Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(8):1389-98.
1990: W H Meyer; J A Houghton; Peter J Houghton; B L Webber; E C Douglass; A Thomas Look
Development and characterization of pediatric osteosarcoma xenografts.
Cancer research 1990;50(9):2781-5.
1990: Victor M Santana; R K Dodge; W M Crist; Jaime Rivera; A Thomas Look; Frederick G. Behm; Susana C Raimondi; Ching-Hon Pui
Presenting features and treatment outcome of adolescents with acute lymphoblastic leukemia.
Leukemia 1990;4(2):87-90.
1989: W M Roberts; E C Douglass; Stephen Peiper; Peter J Houghton; A Thomas Look
Amplification of the gli gene in childhood sarcomas.
Cancer research 1989;49(19):5407-13.
1989: Ching-Hon Pui; Susana C Raimondi; R K Dodge; Jaime Rivera; L A Fuchs; M Abromowitch; A Thomas Look; Wayne L Furman; William M Crist; D L Williams
Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia.
Blood 1989;73(7):1963-7.
1989: A Thomas Look; RA Ashmun; Linda H. Shapiro; Stephen Peiper
Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
The Journal of clinical investigation 1989;83(4):1299-307.
1989: RA Ashmun; A Thomas Look; W M Roberts; Martine F Roussel; S Seremetis; M Ohtsuka; Charles J Sherr
Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells.
Blood 1989;73(3):827-37.
1989: M Valentine; E C Douglass; A Thomas Look
Closely linked loci on the long arm of chromosome 13 flank a specific 2;13 translocation breakpoint in childhood rhabdomyosarcoma.
Cytogenetics and cell genetics 1989;52(3-4):128-32.
1989: A Thomas Look
Constellations of genetic abnormalities predict clinical outcome in childhood malignancies.
Haematology and blood transfusion 1989;32():113-20.
1988: W M Roberts; A Thomas Look; Martine F Roussel; Charles J Sherr
Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.
Cell 1988;55(4):655-61.
1988: A Thomas Look; E C Douglass; W H Meyer
Clinical importance of near-diploid tumor stem lines in patients with osteosarcoma of an extremity.
The New England journal of medicine 1988;318(24):1567-72.
1988: M Abromowitch; J Ochs; Ching-Hon Pui; D Kalwinsky; Jaime Rivera; D Fairclough; A Thomas Look; H O Hustu; S B Murphy; William Evans
High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X.
Medical and pediatric oncology 1988;16(5):297-303.
1987: N Hakami; A Thomas Look; P C Steuber; J Krischer; R Castleberry; R Harris; Yaddanapudi Ravindranath; Teresa J Vietti
Combined etoposide and 5-azacitidine in children and adolescents with refractory or relapsed acute nonlymphocytic leukemia: a Pediatric Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(7):1022-5.