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Richard Look

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TOP 3
Min Amy Xiang; Philip J Rybczynski; Mona Patel; Robert H Chen; David F McComsey; Han-Cheng Zhang; Joseph W Gunnet; Richard Look; Yuanping Wang; Lisa K Minor; H Marlon Zhong; Frank J Villani; Keith T Demarest; Bruce Damiano; Bruce E Maryanoff
Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Joseph W Gunnet; Jay M Matthews; Bruce E Maryanoff; Lawrence de Garavilla; Patricia Andrade-Gordon; Bruce Damiano; William Hageman; Richard Look; Paul Stahle; Anthony J Streeter; Pamela G Wines; Keith T Demarest
Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist.
Joseph Dudash; Yongzheng Zhang; John B Moore; Richard Look; Yin Liang; Mary Pat Beavers; Bruce R Conway; Philip J Rybczynski; Keith T Demarest
Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.

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All Publications

2007: Min Amy Xiang; Philip J Rybczynski; Mona Patel; Robert H Chen; David F McComsey; Han-Cheng Zhang; Joseph W Gunnet; Richard Look; Yuanping Wang; Lisa K Minor; H Marlon Zhong; Frank J Villani; Keith T Demarest; Bruce Damiano; Bruce E Maryanoff
Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Bioorganic & medicinal chemistry letters 2007;17(23):6623-8.
2006: Joseph W Gunnet; Jay M Matthews; Bruce E Maryanoff; Lawrence de Garavilla; Patricia Andrade-Gordon; Bruce Damiano; William Hageman; Richard Look; Paul Stahle; Anthony J Streeter; Pamela G Wines; Keith T Demarest
Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist.
Clinical and experimental pharmacology & physiology 2006;33(4):320-6.
2005: Joseph Dudash; Yongzheng Zhang; John B Moore; Richard Look; Yin Liang; Mary Pat Beavers; Bruce R Conway; Philip J Rybczynski; Keith T Demarest
Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(21):4790-3.
2004: Han-Cheng Zhang; Hong Ye; Bruce R Conway; Claudia K Derian; Michael F Addo; Gee-Hong Kuo; Leonard R Hecker; Diane R Croll; Jian Li; Lori Westover; Jun Z Xu; Richard Look; Keith T Demarest; Patricia Andrade-Gordon; Bruce Damiano; Bruce E Maryanoff
3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.
Bioorganic & medicinal chemistry letters 2004;14(12):3245-50.
2004: Min Amy Xiang; Robert H Chen; Keith T Demarest; Joseph W Gunnet; Richard Look; William Hageman; William V Murray; Donald W Combs; Philip J Rybczynski; Mona Patel
Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists.
Bioorganic & medicinal chemistry letters 2004;14(12):3143-6.
2004: Min Amy Xiang; Robert H Chen; Keith T Demarest; Joseph W Gunnet; Richard Look; William Hageman; William V Murray; Donald W Combs; Mona Patel
Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(11):2987-9.
2004: Jay M Matthews; William J Hoekstra; Alexey B Dyatkin; Leonard R Hecker; Dennis J Hlasta; Brenda L Poulter; Patricia Andrade-Gordon; Lawrence de Garavilla; Keith T Demarest; Eric Ericson; Joseph W Gunnet; William Hageman; Richard Look; John B Moore; Charles H Reynolds; Bruce E Maryanoff
Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.
Bioorganic & medicinal chemistry letters 2004;14(11):2747-52.
2004: Lan Shen; Catherine Prouty; Bruce R Conway; Lori Westover; Jun Z Xu; Richard Look; Xin Chen; Mary Pat Beavers; Jerry Roberts; William V Murray; Keith T Demarest; Gee-Hong Kuo
Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors.
Bioorganic & medicinal chemistry 2004;12(5):1239-55.
2003: Maud Urbanski; Robert H Chen; Keith T Demarest; Joseph W Gunnet; Richard Look; Eric Ericson; William V Murray; Philip J Rybczynski; Xiaoyan Zhang
2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(22):4031-4.
2003: Han-Cheng Zhang; Kimberly B White; Hong Ye; David F McComsey; Claudia K Derian; Michael F Addo; Patricia Andrade-Gordon; Annette J Eckardt; Bruce R Conway; Lori Westover; Jun Z Xu; Richard Look; Keith T Demarest; Stuart Emanuel; Bruce E Maryanoff
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Bioorganic & medicinal chemistry letters 2003;13(18):3049-53.
2003: Gee-Hong Kuo; Catherine Prouty; Alan DeAngelis; Lan Shen; David J O'Neill; Chandra Shah; Peter J Connolly; William V Murray; Bruce R Conway; Peter Cheung; Lori Westover; Jun Z Xu; Richard Look; Keith T Demarest; Stuart Emanuel; Steven A Middleton; Linda Jolliffe; Mary Pat Beavers; Xin Chen
Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.
Journal of medicinal chemistry 2003;46(19):4021-31.
2003: Jay M Matthews; Michael N Greco; Leonard R Hecker; William J Hoekstra; Patricia Andrade-Gordon; Lawrence de Garavilla; Keith T Demarest; Eric Ericson; Joseph W Gunnet; William Hageman; Richard Look; John B Moore; Bruce E Maryanoff
Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(4):753-6.
2002: Alexey B Dyatkin; William J Hoekstra; Dennis J Hlasta; Patricia Andrade-Gordon; Lawrence de Garavilla; Keith T Demarest; Joseph W Gunnet; William Hageman; Richard Look; Bruce E Maryanoff
Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.
Bioorganic & medicinal chemistry letters 2002;12(21):3081-4.