Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Richard LoPachin

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Chemicals & Drugs

Anatomy

Procedures

Electron Probe Microanalysis

Disorders

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
29
Lehning, Ellen
11
Barber, David
7
Eichberg, Joseph
7
Stys, Peter
6
Gaughan, Christopher
6
Jortner, Bernard
6
Ross, JF
6
Das, Soma
5
Reid, Maria
4
Balaban, CD
4
Opanashuk, Lisa
4
He, Deke
3
Aschner, Michael
2
Ehrich, Marion
2
Peterson, Richard

Sign-in to see all Coauthors

Publications

TOP 3
LoPachin Richard M; Gavin Terrence; Petersen Dennis R; Barber David S
Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.
Lopachin Richard M; Geohagen Brian C; Gavin Terrence
Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.
DeCaprio Anthony P; Kinney Elizabeth A; LoPachin Richard M
Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Richard LoPachin (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: LoPachin Richard M; Gavin Terrence; Petersen Dennis R; Barber David S
Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.
Chemical research in toxicology 2009;22(9):1499-508.
2009: Lopachin Richard M; Geohagen Brian C; Gavin Terrence
Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.
Toxicological sciences : an official journal of the Society of Toxicology 2009;107(1):171-81.
2009: DeCaprio Anthony P; Kinney Elizabeth A; LoPachin Richard M
Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat.
Journal of toxicology and environmental health. Part A 2009;72(14):861-9.
2008: Lopachin Richard M; Gavin Terrence; Barber David S
Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases.
Neurotoxicology 2008;29(5):871-82.
2008: Lopachin Richard M; Gavin Terrence
Acrylamide-induced nerve terminal damage: relevance to neurotoxic and neurodegenerative mechanisms.
Journal of agricultural and food chemistry 2008;56(15):5994-6003.
2008: LoPachin Richard M; Barber David S; Gavin Terrence
Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):235-49.
2008: LoPachin Richard M; Gavin Terrence
Response to "Paraquat: the red herring of Parkinson's disease research".
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):219-21; author reply 222-3.
2007: Barber David S; Stevens Stanley; LoPachin Richard M
Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):156-67.
2007: LoPachin Richard M; Gavin Terrence; Geohagen Brian C; Das Soma
Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parameters.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):561-70.
2007: Lopachin Richard M; Barber David S; Geohagen Brian C; Gavin Terrence; He Deke; Das Soma
Structure-toxicity analysis of type-2 alkenes: in vitro neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):136-46.
2006: LoPachin Richard M; Barber David S
Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):240-55.
2006: LoPachin Richard M; Barber David S; He Deke; Das Soma
Acrylamide inhibits dopamine uptake in rat striatal synaptic vesicles.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(1):224-34.
2005: Lopachin Richard M; Jortner Bernard S; Reid Maria L; Monir Alim
Gamma-Diketone central neuropathy: quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract.
Neurotoxicology 2005;26(6):1021-30.
2005: Lopachin Richard M; Decaprio Anthony P
Protein adduct formation as a molecular mechanism in neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):214-25.
2005: LoPachin Richard M; He Deke; Reid Maria L
2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve.
Neurotoxicology 2005;26(2):229-40.
2005: LoPachin Richard M
Acrylamide neurotoxicity: neurological, morhological and molecular endpoints in animal models.
Advances in experimental medicine and biology 2005;561():21-37.
2004: Barber David S; LoPachin Richard M
Proteomic analysis of acrylamide-protein adduct formation in rat brain synaptosomes.
Toxicology and applied pharmacology 2004;201(2):120-36.
2004: LoPachin Richard M; DeCaprio Anthony P
gamma-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction.
Toxicology and applied pharmacology 2004;199(1):20-34.
2004: LoPachin Richard M; He Deke; Reid Maria L; Opanashuk Lisa A
2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions.
Toxicology and applied pharmacology 2004;198(1):61-73.
2004: LoPachin Richard M; Canady Richard A
Acrylamide toxicities and food safety: Session IV summary and research needs.
Neurotoxicology 2004;25(4):507-9.
2004: LoPachin Richard M
The changing view of acrylamide neurotoxicity.
Neurotoxicology 2004;25(4):617-30.
2004: LoPachin Richard M; Schwarcz Aron I; Gaughan Christopher L; Mansukhani Shirley; Das Soma
In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and release.
Neurotoxicology 2004;25(3):349-63.
2003: LoPachin Richard M; Jones Richard C; Patterson Tucker A; Slikker William; Barber David S
Application of proteomics to the study of molecular mechanisms in neurotoxicology.
Neurotoxicology 2003;24(6):761-75.
2003: LoPachin Richard M; Jortner Bernard S; Reid Maria L; Das Soma
gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots.
Toxicology and applied pharmacology 2003;193(1):29-46.
2003: LoPachin R M; Balaban C D; Ross J F
Acrylamide axonopathy revisited.
Toxicology and applied pharmacology 2003;188(3):135-53.
2003: Lehning E J; Balaban C D; Ross J F; LoPachin R M
Acrylamide neuropathy. III. Spatiotemporal characteristics of nerve cell damage in forebrain.
Neurotoxicology 2003;24(1):125-36.
2003: Lehning E J; Balaban C D; Ross J F; LoPachin R M
Acrylamide neuropathy. II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord.
Neurotoxicology 2003;24(1):109-23.
2002: Lehning E J; Balaban C D; Ross J F; Reid M A; LoPachin R M
Acrylamide neuropathy. I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum.
Neurotoxicology 2002;23(3):397-414.
2002: LoPachin Richard M
The role of fast axonal transport in acrylamide pathophysiology: mechanism or epiphenomenon?
Neurotoxicology 2002;23(2):253-7; discussion 265-70.
2002: LoPachin R M; Ross J F; Reid M L; Das S; Mansukhani S; Lehning E J
Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione.
Neurotoxicology 2002;23(1):95-110.
2002: LoPachin R M; Ross J F; Lehning E J
Nerve terminals as the primary site of acrylamide action: a hypothesis.
Neurotoxicology 2002;23(1):43-59.
2001: Barber D S; Hunt J; LoPachin R M; Ehrich M
Determination of acrylamide and glycidamide in rat plasma by reversed-phase high performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;758(2):289-93.
2001: Barber D S; Hunt J R; Ehrich M F; Lehning E J; LoPachin R M
Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing.
Neurotoxicology 2001;22(3):341-53.
2001: Opanashuk L A; He D K; Lehning E J; LoPachin R M
Gamma-diketone peripheral neuropathy III. Neurofilament gene expression.
Neurotoxicology 2001;22(2):215-20.
2001: LoPachin R M; Gaughan C L; Lehning E J; Weber M L; Taylor C P
Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons.
Neuroscience 2001;103(4):971-83.
2000: LoPachin R M; Lehning E J; Opanashuk L A; Jortner B S
Rate of neurotoxicant exposure determines morphologic manifestations of distal axonopathy.
Toxicology and applied pharmacology 2000;167(2):75-86.
2000: Chiu F C; Opanashuk L A; He D K; Lehning E J; LoPachin R M
gamma-diketone peripheral neuropathy. II. Neurofilament subunit content.
Toxicology and applied pharmacology 2000;165(2):141-7.
2000: Lehning E J; Jortner B S; Fox J H; Arezzo J C; Kitano T; LoPachin R M
gamma-diketone peripheral neuropathy. I. Quality morphometric analyses of axonal atrophy and swelling.
Toxicology and applied pharmacology 2000;165(2):127-40.
2000: LoPachin R M
Redefining toxic distal axonopathies.
Toxicology letters 2000;112-113():23-33.
1999: LoPachin R M; Gaughan C L; Lehning E J; Kaneko Y; Kelly T M; Blight A
Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia.
Journal of neurophysiology 1999;82(5):2143-53.
1999: Audesirk G; Burbacher T; Guilarte T R; Laughlin N K; Lopachin R; Suszkiw J; Tilson H
Understanding the NIH review process: a brief guide to writing grant proposals in neurotoxicology.
Neurotoxicology 1999;20(1):91-7.
1999: Taylor C P; Weber M L; Gaughan C L; Lehning E J; LoPachin R M
Oxygen/glucose deprivation in hippocampal slices: altered intraneuronal elemental composition predicts structural and functional damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):619-29.
1999: Lopachin R M
Intraneuronal ion distribution during experimental oxygen/glucose deprivation. Routes of ion flux as targets of neuroprotective strategies.
Annals of the New York Academy of Sciences 1999;890():191-203.
1999: Aschner M; Allen J W; Kimelberg H K; LoPachin R M; Streit W J
Glial cells in neurotoxicity development.
Annual review of pharmacology and toxicology 1999;39():151-73.
1998: Lehning E J; Persaud A; Dyer K R; Jortner B S; LoPachin R M
Biochemical and morphologic characterization of acrylamide peripheral neuropathy.
Toxicology and applied pharmacology 1998;151(2):211-21.
1998: Stys P K; Lopachin R M
Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons.
Neuroscience 1998;82(1):21-32.
1997: Lehning E J; Gaughan C L; Eichberg J; LoPachin R M
Rubidium uptake and accumulation in peripheral myelinated internodal axons and Schwann cells.
Journal of neurochemistry 1997;69(3):968-77.
1997: Stys P K; Lehning E; Saubermann A J; LoPachin R M
Intracellular concentrations of major ions in rat myelinated axons and glia: calculations based on electron probe X-ray microanalyses.
Journal of neurochemistry 1997;68(5):1920-8.
1997: LoPachin R M; Lehning E J
Mechanism of calcium entry during axon injury and degeneration.
Toxicology and applied pharmacology 1997;143(2):233-44.
1997: Lehning E J; Gaughan C L; LoPachin R M
Acrylamide intoxication modifies in vitro responses of peripheral nerve axons to anoxia.
Journal of the peripheral nervous system : JPNS 1997;2(2):165-74.
1997: LoPachin R M; Lehning E J
The relevance of axonal swellings and atrophy to gamma-diketone neurotoxicity: a forum position paper.
Neurotoxicology 1997;18(1):7-22.
1996: Stys P K; Lopachin R M
Elemental composition and water content of rat optic nerve myelinated axons during in vitro post-anoxia reoxygenation.
Neuroscience 1996;73(4):1081-90.
1996: Lehning E J; Stys P K; LoPachin R M
Reoxygenation of anoxic peripheral nerve myelinated axons promotes re-establishment of normal elemental composition.
Brain research 1996;715(1-2):189-96.
1996: Lehning E J; Doshi R; Isaksson N; Stys P K; LoPachin R M
Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: role of reverse sodium-calcium exchange.
Journal of neurochemistry 1996;66(2):493-500.
1995: Lehning E J; Dyer K S; Jortner B S; LoPachin R M
Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy.
Toxicology and applied pharmacology 1995;135(1):58-66.
1995: Lehning E J; Doshi R; Stys P K; LoPachin R M
Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: in vitro anoxia and ouabain exposure.
Brain research 1995;694(1-2):158-66.
1995: LoPachin R M; Stys P K
Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(10):6735-46.
1994: LoPachin R M; Lehning E J; Stack E C; Hussein S J; Saubermann A J
2,5-Hexanedione alters elemental composition and water content of rat peripheral nerve myelinated axons.
Journal of neurochemistry 1994;63(6):2266-78.
1994: Lehning E J; LoPachin R M; Mathew J; Eichberg J
Changes in Na-K ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats.
Journal of toxicology and environmental health 1994;42(3):331-42.
1994: LoPachin R M; Lehning E J
Acrylamide-induced distal axon degeneration: a proposed mechanism of action.
Neurotoxicology 1994;15(2):247-59.
1994: LoPachin R M; Lehning E J; Stack E C; Saubermann A J
Disruption of Schwann cell elemental composition is not a primary neurotoxic effect of 2,5-hexanedione.
Neurotoxicology 1994;15(4):927-34.
1993: LoPachin R M; Lehning E J; Castiglia C M; Saubermann A J
Acrylamide disrupts elemental composition and water content of rat tibial nerve. III. Recovery.
Toxicology and applied pharmacology 1993;122(1):54-60.
1993: LoPachin R M; Castiglia C M; Lehning E; Saubermann A J
Effects of acrylamide on subcellular distribution of elements in rat sciatic nerve myelinated axons and Schwann cells.
Brain research 1993;608(2):238-46.
1993: Aschner M; LoPachin R M
Astrocytes: targets and mediators of chemical-induced CNS injury.
Journal of toxicology and environmental health 1993;38(3):329-42.
1993: LoPachin R M; Aschner M
Glial-neuronal interactions: relevance to neurotoxic mechanisms.
Toxicology and applied pharmacology 1993;118(2):141-58.
1993: LoPachin R M; Castiglia C M; Saubermann A J; Eichberg J
Ganglioside treatment modifies abnormal elemental composition in peripheral nerve myelinated axons of experimentally diabetic rats.
Journal of neurochemistry 1993;60(2):477-86.
1993: Eichberg J; Bianchi R; Fiori M G; Triban C; Zhu X; LoPachin R M
Diabetic neuropathy and the pharmacology of gangliosides.
Diabetic medicine : a journal of the British Diabetic Association 1993;10 Suppl 2():98S-102S.
1992: LoPachin R M; Castiglia C M; Saubermann A J
Acrylamide disrupts elemental composition and water content of rat tibial nerve. II. Schwann cells and myelin.
Toxicology and applied pharmacology 1992;115(1):35-43.
1992: LoPachin R M; Castiglia C M; Saubermann A J
Acrylamide disrupts elemental composition and water content of rat tibial nerve. I. Myelinated axons.
Toxicology and applied pharmacology 1992;115(1):21-34.
1992: LoPachin R M; Castiglia C M; Saubermann A J
Perturbation of axonal elemental composition and water content: implication for neurotoxic mechanisms.
Neurotoxicology 1992;13(1):123-37.
1991: LoPachin R M; Castiglia C M; Saubermann A J
Elemental composition and water content of myelinated axons and glial cells in rat central nervous system.
Brain research 1991;549(2):253-9.
1990: Lowery J M; Eichberg J; Saubermann A J; LoPachin R M
Distribution of elements and water in peripheral nerve of streptozocin-induced diabetic rats.
Diabetes 1990;39(12):1498-503.
1990: LoPachin R M; Saubermann A J
Disruption of cellular elements and water in neurotoxicity: studies using electron probe X-ray microanalysis.
Toxicology and applied pharmacology 1990;106(3):355-74.
1990: Berti-Mattera L N; Eichberg J; Schrama L; LoPachin R M
Acrylamide administration alters protein phosphorylation and phospholipid metabolism in rat sciatic nerve.
Toxicology and applied pharmacology 1990;103(3):502-11.
1990: LoPachin R M; LoPachin V R; Saubermann A J
Effects of axotomy on distribution and concentration of elements in rat sciatic nerve.
Journal of neurochemistry 1990;54(1):320-32.
1989: Horan K L; Eichberg J; Berti-Mattera L N; LoPachin R M
Hexanedione effects on protein phosphorylation in rat peripheral nerve.
Brain research 1989;491(2):366-70.
1989: Medrano C J; LoPachin R M
Effects of acrylamide and 2,5-hexanedione on brain mitochondrial respiration.
Neurotoxicology 1989;10(2):249-55.
1988: LoPachin R M; Lowery J; Eichberg J; Kirkpatrick J B; Cartwright J; Saubermann A J
Distribution of elements in rat peripheral axons and nerve cell bodies determined by x-ray microprobe analysis.
Journal of neurochemistry 1988;51(3):764-75.
1986: Williams K D; Lopachin R M; Atchison W D; Peterson R E
Antagonism of dithiobiuret toxicity in rats.
Neurotoxicology 1986;7(1):33-49.
1984: LoPachin R M; Weiler M S; Williams K D; Peterson R E
Evaluation of the ability of d-penicillamine to protect rats against the neurotoxicity induced by zinc pyridinethione, acrylamide, 2,5-hexanedione and p-bromophenylacetylurea.
Neurotoxicology 1984;5(2):37-41.
1984: LoPachin R M; Moore R W; Menahan L A; Peterson R E
Glucose-dependent lactate production by homogenates of neuronal tissues prepared from rats treated with 2,4-dithiobiuret, acrylamide, p-bromophenylacetylurea and 2,5-hexanedione.
Neurotoxicology 1984;5(2):25-35.
1983: LoPachin R M; Rudy T A
Sites and mechanism of action for the effects of intrathecal noradrenaline on thermoregulation in the rat.
The Journal of physiology 1983;341():527-44.
1982: Lopachin R M; Rudy T A
The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space.
The Journal of physiology 1982;333():511-29.
1981: LoPachin R M; Rudy T A
The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats.
Brain research 1981;224(1):195-8.
1981: LoPachin R M; Rudy T A; Yaksh T L
An improved method for chronic catheterization of the rat spinal subarachnoid space.
Physiology & behavior 1981;27(3):559-61.
1978: LoPachin R M; Reigle T G
The effects of several narcotic analgesics on brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate in the rat.
The Journal of pharmacology and experimental therapeutics 1978;207(1):151-8.

Sign-in to see more