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Richard LoPachin

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Christopher J Martyniuk; David S Barber; Bin Fang; April Feswick; Terrence Gavin; John M Koomen; Richard M LoPachin
Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells.
Richard M LoPachin; Terrence Gavin
Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry.
Richard M LoPachin; Anthony P Decaprio; Terrence Gavin; David S Barber
Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.

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All Publications

2013: Christopher J Martyniuk; David S Barber; Bin Fang; April Feswick; Terrence Gavin; John M Koomen; Richard M LoPachin
Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells.
Toxicology letters 2013;219(3):279-87.
2012: Richard M LoPachin; Terrence Gavin
Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry.
Environmental health perspectives 2012;120(12):1650-7.
2012: Richard M LoPachin; Anthony P Decaprio; Terrence Gavin; David S Barber
Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant--target interactions.
Chemical research in toxicology 2012;25(2):239-51.
2011: Christopher J Martyniuk; David S Barber; Lihai Zhang; Bin Fang; John M Koomen; Terrence Gavin; Richard M LoPachin
Molecular mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by α,β-unsaturated carbonyl derivatives.
Chemical research in toxicology 2011;24(12):2302-11.
2011: Lihai Zhang; David S Barber; Terrence Gavin; Richard M LoPachin
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.
Toxicology letters 2011;205(1):1-7.
2011: Richard M LoPachin; Terrence Gavin; Brian C Geohagen; Lihai Zhang; Diana Casper; Rukmani Lekhraj; David S Barber
β-Dicarbonyl enolates: a new class of neuroprotectants.
Journal of neurochemistry 2011;116(1):132-43.
2010: Lihai Zhang; Terrence Gavin; Anthony P Decaprio; Richard M LoPachin
Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(1):180-9.
2009: Richard M LoPachin; Terrence Gavin; Dennis R Petersen; David S Barber
Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.
Chemical research in toxicology 2009;22(9):1499-508.
2009: Anthony P DeCaprio; Elizabeth A Kinney; Richard M LoPachin
Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat.
Journal of toxicology and environmental health. Part A 2009;72(14):861-9.
2009: Richard M LoPachin; Brian C Geohagen; Terrence Gavin
Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.
Toxicological sciences : an official journal of the Society of Toxicology 2009;107(1):171-81.
2008: Richard M LoPachin; Terrence Gavin; David S Barber
Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases.
Neurotoxicology 2008;29(5):871-82.
2008: Richard M LoPachin; Terrence Gavin
Acrylamide-induced nerve terminal damage: relevance to neurotoxic and neurodegenerative mechanisms.
Journal of agricultural and food chemistry 2008;56(15):5994-6003.
2008: Richard M LoPachin; David S Barber; Terrence Gavin
Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):235-49.
2008: Richard M LoPachin; Terrence Gavin
Response to "Paraquat: the red herring of Parkinson's disease research".
Toxicological sciences : an official journal of the Society of Toxicology 2008;103(1):219-21; author reply 222-3.
2007: David S Barber; Stanley Stevens; Richard M LoPachin
Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):156-67.
2007: Richard M LoPachin; Terrence Gavin; Brian C Geohagen; Soma Das
Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parameters.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):561-70.
2007: Richard M LoPachin; David S Barber; Brian C Geohagen; Terrence Gavin; Deke He; Soma Das
Structure-toxicity analysis of type-2 alkenes: in vitro neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2007;95(1):136-46.
2006: Richard M LoPachin; David S Barber
Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(2):240-55.
2006: Richard M LoPachin; David S Barber; Deke He; Soma Das
Acrylamide inhibits dopamine uptake in rat striatal synaptic vesicles.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(1):224-34.
2005: Richard M LoPachin; Bernard S Jortner; Maria L Reid; Alim Monir
Gamma-Diketone central neuropathy: quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract.
Neurotoxicology 2005;26(6):1021-30.
2005: Richard M LoPachin; Anthony P Decaprio
Protein adduct formation as a molecular mechanism in neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):214-25.
2005: Richard M LoPachin; Deke He; Maria L Reid
2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve.
Neurotoxicology 2005;26(2):229-40.
2005: Richard M LoPachin
Acrylamide neurotoxicity: neurological, morhological and molecular endpoints in animal models.
Advances in experimental medicine and biology 2005;561():21-37.
2004: David S Barber; Richard M LoPachin
Proteomic analysis of acrylamide-protein adduct formation in rat brain synaptosomes.
Toxicology and applied pharmacology 2004;201(2):120-36.
2004: Richard M LoPachin; Anthony P Decaprio
gamma-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction.
Toxicology and applied pharmacology 2004;199(1):20-34.
2004: Richard M LoPachin; Deke He; Maria L Reid; Lisa A Opanashuk
2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions.
Toxicology and applied pharmacology 2004;198(1):61-73.
2004: Richard M LoPachin; Richard A Canady
Acrylamide toxicities and food safety: Session IV summary and research needs.
Neurotoxicology 2004;25(4):507-9.
2004: Richard M LoPachin
The changing view of acrylamide neurotoxicity.
Neurotoxicology 2004;25(4):617-30.
2004: Richard M LoPachin; Aron I Schwarcz; Christopher L Gaughan; Shirley Mansukhani; Soma Das
In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and release.
Neurotoxicology 2004;25(3):349-63.
2003: Richard M LoPachin; Richard C Jones; Patterson Tucker; William Slikker; David S Barber
Application of proteomics to the study of molecular mechanisms in neurotoxicology.
Neurotoxicology 2003;24(6):761-75.
2003: Richard M LoPachin; Bernard S Jortner; Maria L Reid; Soma Das
gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots.
Toxicology and applied pharmacology 2003;193(1):29-46.
2003: Richard M LoPachin; CD Balaban; JF Ross
Acrylamide axonopathy revisited.
Toxicology and applied pharmacology 2003;188(3):135-53.
2003: Ellen J Lehning; CD Balaban; JF Ross; Richard M LoPachin
Acrylamide neuropathy. III. Spatiotemporal characteristics of nerve cell damage in forebrain.
Neurotoxicology 2003;24(1):125-36.
2003: Ellen J Lehning; CD Balaban; JF Ross; Richard M LoPachin
Acrylamide neuropathy. II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord.
Neurotoxicology 2003;24(1):109-23.
2002: Ellen J Lehning; CD Balaban; JF Ross; M A Reid; Richard M LoPachin
Acrylamide neuropathy. I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum.
Neurotoxicology 2002;23(3):397-414.
2002: Richard M LoPachin
The role of fast axonal transport in acrylamide pathophysiology: mechanism or epiphenomenon?
Neurotoxicology 2002;23(2):253-7; discussion 265-70.
2002: Richard M LoPachin; JF Ross; Maria L Reid; Soma Das; S Mansukhani; Ellen J Lehning
Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione.
Neurotoxicology 2002;23(1):95-110.
2002: Richard M LoPachin; JF Ross; Ellen J Lehning
Nerve terminals as the primary site of acrylamide action: a hypothesis.
Neurotoxicology 2002;23(1):43-59.
2001: David S Barber; J Hunt; Richard M LoPachin; Marion Ehrich
Determination of acrylamide and glycidamide in rat plasma by reversed-phase high performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;758(2):289-93.
2001: David S Barber; J R Hunt; Marion Ehrich; Ellen J Lehning; Richard M LoPachin
Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing.
Neurotoxicology 2001;22(3):341-53.
2001: Lisa A Opanashuk; D K He; Ellen J Lehning; Richard M LoPachin
Gamma-diketone peripheral neuropathy III. Neurofilament gene expression.
Neurotoxicology 2001;22(2):215-20.
2001: Richard M LoPachin; Christopher L Gaughan; Ellen J Lehning; Mark L Weber; Charles P Taylor
Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons.
Neuroscience 2001;103(4):971-83.
2000: Richard M LoPachin; Ellen J Lehning; Lisa A Opanashuk; Bernard S Jortner
Rate of neurotoxicant exposure determines morphologic manifestations of distal axonopathy.
Toxicology and applied pharmacology 2000;167(2):75-86.
2000: Fungchow A Chiu; Lisa A Opanashuk; D K He; Ellen J Lehning; Richard M LoPachin
gamma-diketone peripheral neuropathy. II. Neurofilament subunit content.
Toxicology and applied pharmacology 2000;165(2):141-7.
2000: Ellen J Lehning; Bernard S Jortner; J H Fox; Joseph C Arezzo; T Kitano; Richard M LoPachin
gamma-diketone peripheral neuropathy. I. Quality morphometric analyses of axonal atrophy and swelling.
Toxicology and applied pharmacology 2000;165(2):127-40.
2000: Richard M LoPachin
Redefining toxic distal axonopathies.
Toxicology letters 2000;112-113():23-33.
1999: Richard M LoPachin; Christopher L Gaughan; Ellen J Lehning; Y Kaneko; T M Kelly; Andrew R Blight
Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia.
Journal of neurophysiology 1999;82(5):2143-53.
1999: Gerald Audesirk; T Burbacher; Tomás R Guilarte; N K Laughlin; Richard M LoPachin; J Suszkiw; H Tilson
Understanding the NIH review process: a brief guide to writing grant proposals in neurotoxicology.
Neurotoxicology 1999;20(1):91-7.
1999: Charles P Taylor; Mark L Weber; Christopher L Gaughan; Ellen J Lehning; Richard M LoPachin
Oxygen/glucose deprivation in hippocampal slices: altered intraneuronal elemental composition predicts structural and functional damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):619-29.
1999: Richard M LoPachin; Christopher L Gaughan
Electron probe x-ray microanalysis: a quantitative electron microscopy technique for measurement of elements and water in nervous tissue cells.
Methods in molecular medicine 1999;22():289-99.
1999: Richard M LoPachin
Intraneuronal ion distribution during experimental oxygen/glucose deprivation. Routes of ion flux as targets of neuroprotective strategies.
Annals of the New York Academy of Sciences 1999;890():191-203.
1999: Michael Aschner; J W Allen; H K Kimelberg; Richard M LoPachin; W J Streit
Glial cells in neurotoxicity development.
Annual review of pharmacology and toxicology 1999;39():151-73.
1998: Ellen J Lehning; A Persaud; K R Dyer; Bernard S Jortner; Richard M LoPachin
Biochemical and morphologic characterization of acrylamide peripheral neuropathy.
Toxicology and applied pharmacology 1998;151(2):211-21.
1998: Peter K Stys; Richard M LoPachin
Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons.
Neuroscience 1998;82(1):21-32.
1997: Ellen J Lehning; Christopher L Gaughan; J Eichberg; Richard M LoPachin
Rubidium uptake and accumulation in peripheral myelinated internodal axons and Schwann cells.
Journal of neurochemistry 1997;69(3):968-77.
1997: Peter K Stys; Ellen J Lehning; A J Saubermann; Richard M LoPachin
Intracellular concentrations of major ions in rat myelinated axons and glia: calculations based on electron probe X-ray microanalyses.
Journal of neurochemistry 1997;68(5):1920-8.
1997: Richard M LoPachin; Ellen J Lehning
Mechanism of calcium entry during axon injury and degeneration.
Toxicology and applied pharmacology 1997;143(2):233-44.
1997: Ellen J Lehning; Christopher L Gaughan; Richard M LoPachin
Acrylamide intoxication modifies in vitro responses of peripheral nerve axons to anoxia.
Journal of the peripheral nervous system : JPNS 1997;2(2):165-74.
1997: Richard M LoPachin; Ellen J Lehning
The relevance of axonal swellings and atrophy to gamma-diketone neurotoxicity: a forum position paper.
Neurotoxicology 1997;18(1):7-22.
1996: Peter K Stys; Richard M LoPachin
Elemental composition and water content of rat optic nerve myelinated axons during in vitro post-anoxia reoxygenation.
Neuroscience 1996;73(4):1081-90.
1996: Ellen J Lehning; Peter K Stys; Richard M LoPachin
Reoxygenation of anoxic peripheral nerve myelinated axons promotes re-establishment of normal elemental composition.
Brain research 1996;715(1-2):189-96.
1996: Ellen J Lehning; R Doshi; N Isaksson; Peter K Stys; Richard M LoPachin
Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: role of reverse sodium-calcium exchange.
Journal of neurochemistry 1996;66(2):493-500.
1995: Ellen J Lehning; K S Dyer; Bernard S Jortner; Richard M LoPachin
Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy.
Toxicology and applied pharmacology 1995;135(1):58-66.
1995: Ellen J Lehning; R Doshi; Peter K Stys; Richard M LoPachin
Mechanisms of injury-induced calcium entry into peripheral nerve myelinated axons: in vitro anoxia and ouabain exposure.
Brain research 1995;694(1-2):158-66.
1995: Richard M LoPachin; Peter K Stys
Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(10):6735-46.
1994: Richard M LoPachin; Ellen J Lehning; E C Stack; S J Hussein; A J Saubermann
2,5-Hexanedione alters elemental composition and water content of rat peripheral nerve myelinated axons.
Journal of neurochemistry 1994;63(6):2266-78.
1994: Ellen J Lehning; Richard M LoPachin; J Mathew; Joseph Eichberg
Changes in Na-K ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats.
Journal of toxicology and environmental health 1994;42(3):331-42.
1994: Richard M LoPachin; Ellen J Lehning
Acrylamide-induced distal axon degeneration: a proposed mechanism of action.
Neurotoxicology 1994;15(2):247-59.
1994: Richard M LoPachin; Ellen J Lehning; E C Stack; A J Saubermann
Disruption of Schwann cell elemental composition is not a primary neurotoxic effect of 2,5-hexanedione.
Neurotoxicology 1994;15(4):927-34.
1993: Richard M LoPachin; Ellen J Lehning; C M Castiglia; A J Saubermann
Acrylamide disrupts elemental composition and water content of rat tibial nerve. III. Recovery.
Toxicology and applied pharmacology 1993;122(1):54-60.
1993: Richard M LoPachin; C M Castiglia; Ellen J Lehning; A J Saubermann
Effects of acrylamide on subcellular distribution of elements in rat sciatic nerve myelinated axons and Schwann cells.
Brain research 1993;608(2):238-46.
1993: Michael Aschner; Richard M LoPachin
Astrocytes: targets and mediators of chemical-induced CNS injury.
Journal of toxicology and environmental health 1993;38(3):329-42.
1993: Richard M LoPachin; Michael Aschner
Glial-neuronal interactions: relevance to neurotoxic mechanisms.
Toxicology and applied pharmacology 1993;118(2):141-58.
1993: Richard M LoPachin; C M Castiglia; A J Saubermann; Joseph Eichberg
Ganglioside treatment modifies abnormal elemental composition in peripheral nerve myelinated axons of experimentally diabetic rats.
Journal of neurochemistry 1993;60(2):477-86.
1993: Joseph Eichberg; R Bianchi; M G Fiori; C Triban; X Zhu; Richard M LoPachin
Diabetic neuropathy and the pharmacology of gangliosides.
Diabetic medicine : a journal of the British Diabetic Association 1993;10 Suppl 2():98S-102S.
1992: Richard M LoPachin; C M Castiglia; A J Saubermann
Acrylamide disrupts elemental composition and water content of rat tibial nerve. II. Schwann cells and myelin.
Toxicology and applied pharmacology 1992;115(1):35-43.
1992: Richard M LoPachin; C M Castiglia; A J Saubermann
Acrylamide disrupts elemental composition and water content of rat tibial nerve. I. Myelinated axons.
Toxicology and applied pharmacology 1992;115(1):21-34.
1992: Richard M LoPachin; C M Castiglia; A J Saubermann
Perturbation of axonal elemental composition and water content: implication for neurotoxic mechanisms.
Neurotoxicology 1992;13(1):123-37.
1991: Richard M LoPachin; C M Castiglia; A J Saubermann
Elemental composition and water content of myelinated axons and glial cells in rat central nervous system.
Brain research 1991;549(2):253-9.
1990: J M Lowery; Joseph Eichberg; A J Saubermann; Richard M LoPachin
Distribution of elements and water in peripheral nerve of streptozocin-induced diabetic rats.
Diabetes 1990;39(12):1498-503.
1990: Richard M LoPachin; A J Saubermann
Disruption of cellular elements and water in neurotoxicity: studies using electron probe X-ray microanalysis.
Toxicology and applied pharmacology 1990;106(3):355-74.
1990: L N Berti-Mattera; Joseph Eichberg; L Schrama; Richard M LoPachin
Acrylamide administration alters protein phosphorylation and phospholipid metabolism in rat sciatic nerve.
Toxicology and applied pharmacology 1990;103(3):502-11.
1990: Richard M LoPachin; V R LoPachin; A J Saubermann
Effects of axotomy on distribution and concentration of elements in rat sciatic nerve.
Journal of neurochemistry 1990;54(1):320-32.
1989: K L Horan; Joseph Eichberg; L N Berti-Mattera; Richard M LoPachin
Hexanedione effects on protein phosphorylation in rat peripheral nerve.
Brain research 1989;491(2):366-70.
1989: C J Medrano; Richard M LoPachin
Effects of acrylamide and 2,5-hexanedione on brain mitochondrial respiration.
Neurotoxicology 1989;10(2):249-55.
1988: Richard M LoPachin; J Lowery; Joseph Eichberg; J B Kirkpatrick; J Cartwright; A J Saubermann
Distribution of elements in rat peripheral axons and nerve cell bodies determined by x-ray microprobe analysis.
Journal of neurochemistry 1988;51(3):764-75.
1986: K D Williams; Richard M LoPachin; William D Atchison; Richard E Peterson
Antagonism of dithiobiuret toxicity in rats.
Neurotoxicology 1986;7(1):33-49.
1984: Richard M LoPachin; M S Weiler; K D Williams; Richard E Peterson
Evaluation of the ability of d-penicillamine to protect rats against the neurotoxicity induced by zinc pyridinethione, acrylamide, 2,5-hexanedione and p-bromophenylacetylurea.
Neurotoxicology 1984;5(2):37-41.
1984: Richard M LoPachin; R W Moore; L A Menahan; R E Peterson
Glucose-dependent lactate production by homogenates of neuronal tissues prepared from rats treated with 2,4-dithiobiuret, acrylamide, p-bromophenylacetylurea and 2,5-hexanedione.
Neurotoxicology 1984;5(2):25-35.
1983: Richard M LoPachin; T A Rudy
Sites and mechanism of action for the effects of intrathecal noradrenaline on thermoregulation in the rat.
The Journal of physiology 1983;341():527-44.
1982: Richard M LoPachin; T A Rudy
The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space.
The Journal of physiology 1982;333():511-29.
1981: Richard M LoPachin; T A Rudy
The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats.
Brain research 1981;224(1):195-8.
1981: Richard M LoPachin; T A Rudy; T L Yaksh
An improved method for chronic catheterization of the rat spinal subarachnoid space.
Physiology & behavior 1981;27(3):559-61.
1978: Richard M LoPachin; T G Reigle
The effects of several narcotic analgesics on brain levels of 3-methoxy-4-hydroxyphenylethylene glycol sulfate in the rat.
The Journal of pharmacology and experimental therapeutics 1978;207(1):151-8.