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Gary Lopaschuk

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Anatomy

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Myocardial Reperfusion

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TOP 3
Jun Mori; Osama Abo Alrob; Robert A Harris; Gary D Lopaschuk; Cory S Wagg; Gavin Y Oudit
ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4.
Natasha Fillmore; Gary D Lopaschuk
Targeting mitochondrial oxidative metabolism as an approach to treat heart failure.
Pavel Zhabyeyev; Ratnadeep Basu; Alexander Clanachan; Manoj Gandhi; Zamaneh Kassiri; Gary D Lopaschuk; Jun Mori; Gavin Y Oudit
Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload.

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All Publications

2013: Jun Mori; Osama Abo Alrob; Robert A Harris; Gary D Lopaschuk; Cory S Wagg; Gavin Y Oudit
ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4.
American journal of physiology. Heart and circulatory physiology 2013;304(8):H1103-13.
2013: Natasha Fillmore; Gary D Lopaschuk
Targeting mitochondrial oxidative metabolism as an approach to treat heart failure.
Biochimica et biophysica acta 2013;1833(4):857-65.
2013: Pavel Zhabyeyev; Ratnadeep Basu; Alexander Clanachan; Manoj Gandhi; Zamaneh Kassiri; Gary D Lopaschuk; Jun Mori; Gavin Y Oudit
Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload.
Cardiovascular research 2013;97(4):676-85.
2013: Lin Piao; John J Ryan; Vaninder K Sidhu; Peter T Toth; Yong-Hu Fang; Zhigang Hong; Shelby Kutty; Gary D Lopaschuk; Erik Morrow; Kishan S Parikh; Stephen L Archer
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Journal of molecular medicine (Berlin, Germany) 2013;91(3):333-46.
2013: Wendy Keung; Victoria H M Lam; Monique Raubenheimer; John R Ussher; Cory S Wagg; Jagdip S Jaswal; Gary D Lopaschuk
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.
Diabetes 2013;62(3):711-20.
2013: Gengshu Wu; Liyan Zhang; Azeret Zuniga; René L Jacobs; Liang Li; Tete Li; Gary D Lopaschuk; Dennis E Vance
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
The Journal of biological chemistry 2013;288(2):837-47.
2013: E Douglas Lewandowski; Gary D Lopaschuk; Lori A Walker; Xuerong Wang; Natasha Hausler Banke; Matthew Fasano; Susan K Fischer; Alda Huqi; J Michael O'Donnell
Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy.
Circulation research 2013;112(1):57-65.
2013: Dukgyu Lee; Peter E Light; Gary D Lopaschuk; Kimitoshi Nakamura; Barbara E Nickel; Tatsujiro Oka; Michal Opas; Sylvia Papp; Alison Robinson; Wattamon Srisakuldee; Jason R B Dyck; Beth Hunter; Elissavet Kardami; Marek Michalak
Calreticulin induces dilated cardiomyopathy.
PloS one 2013;8(2):e56387.
2012: Victor Samokhvalov; John M Seubert; John R Ussher; Daniel Moroz; Ian K G Armstrong; Natasha Fillmore; Wendy Keung; David G Lopaschuk; Gary D Lopaschuk
Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.
American journal of physiology. Endocrinology and metabolism 2012;303(12):E1459-68.
2012: Jagdip S Jaswal; Gary D Lopaschuk; John R Ussher; David E Johnstone
Something old holds potential to be something new in heart failure: allopurinol revisited.
The Canadian journal of cardiology 2012;28(6):626-8.
2012: Sam Cherian; Gary D Lopaschuk; Eugenia Carvalho
Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease.
American journal of physiology. Endocrinology and metabolism 2012;303(8):E937-49.
2012: John R Ussher; Jagdip S Jaswal; Gary D Lopaschuk
Pyridine nucleotide regulation of cardiac intermediary metabolism.
Circulation research 2012;111(5):628-41.
2012: Gary D Lopaschuk; Jagdip S Jaswal
A role for period 2 in cardioprotection.
Cell metabolism 2012;16(1):2-4.
2012: Jun Mori; Vaibhav B Patel; Cory S Wagg; Liyan Zhang; Ratnadeep Basu; Subhash K Das; Zamaneh Kassiri; Gary D Lopaschuk; Brent A McLean; Gavin Y Oudit
Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction.
Circulation. Heart failure 2012;5(4):493-503.
2012: Virgilio J J Cadete; Jagdip S Jaswal; Gary D Lopaschuk; Jolanta Sawicka; Richard Schulz; Danuta Szczesna-Cordary; Grzegorz Sawicki
Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2.
The FEBS journal 2012;279(13):2444-54.
2012: Faye Borthwick; Larry Hryshko; Sandra Elizabeth Kelly; Candace Y Lee; Gary D Lopaschuk; John C L Mamo; Rabban Mangat; James C Russell; Kerry-Anne Rye; Richard R E Uwiera; Samantha Warnakula; Spencer D Proctor
ApoA-1 infusion reduces arterial cholesterol and myocardial lesions in a rat model of cardiac dysfunction and insulin resistance.
Atherosclerosis 2012;222(2):402-8.
2012: John R Ussher; Gary D Lopaschuk
An ACE up your sleeve: 2 is better than 1.
Circulation research 2012;110(10):1270-2.
2012: John R Ussher; Cory S Wagg; Wei Wang; Tatsujiro Oka; Victor Samokhvalov; Alexander S Clanachan; Jason R B Dyck; Manoj Gandhi; Robert A Harris; Jagdip S Jaswal; Wendy Keung; Gary D Lopaschuk
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.
Cardiovascular research 2012;94(2):359-69.
2012: Tatsujiro Oka; Ivan M Rebeyka; Victor Samokhvalov; Brandon A Tanner; John R Ussher; Liyan Zhang; Donna L Beker; Virgilio J J Cadete; Alda Huqi; Jagdip S Jaswal; Wendy Keung; Victoria H Lam; Gary D Lopaschuk
Cardiac hypertrophy in the newborn delays the maturation of fatty acid β-oxidation and compromises postischemic functional recovery.
American journal of physiology. Heart and circulatory physiology 2012;302(9):H1784-94.
2012: Liyan Zhang; Jun Mori; Cory Wagg; Gary D Lopaschuk
Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding.
FEBS letters 2012;586(7):996-1003.
2012: Gary D Lopaschuk; Jagdip S Jaswal
Hypoxia-induced adaptation to mitral regurgitation: a role for K ATP channel up-regulation?
Journal of the American College of Cardiology 2012;59(4):397-9.
2012: John R Ussher; Liyan Zhang; Donna L Beker; Virgilio J Cadete; Natasha Fillmore; Clifford D L Folmes; Jagdip S Jaswal; Wendy Keung; Victoria H Lam; Gary D Lopaschuk
Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.
PloS one 2012;7(5):e37703.
2011: Raymond K Kudej; Mathew Fasano; Susan K Fischer; Gary D Lopaschuk; Dorothy E Vatner; Stephen F Vatner; Xin Zhao; E Douglas Lewandowski
Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia.
Cardiovascular research 2011;92(3):394-400.
2011: Wendy Keung; Arivazhagan Palaniyappan; Gary D Lopaschuk
Chronic central leptin decreases food intake and improves glucose tolerance in diet-induced obese mice independent of hypothalamic malonyl CoA levels and skeletal muscle insulin sensitivity.
Endocrinology 2011;152(11):4127-37.
2011: Su Gao; Fausto G Hegardt; Wendy Keung; Patricia Carrasco; Núria Casals; Timothy H Moran; Dolors Serra; Wei Wang; Gary D Lopaschuk
Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(1):R209-17.
2011: Jagdip S Jaswal; Wendy Keung; Wei Wang; John R Ussher; Gary D Lopaschuk
Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.
Biochimica et biophysica acta 2011;1813(7):1333-50.
2011: Su Gao; Xuefei Gao; Fausto G Hegardt; Patricia Carrasco; Núria Casals; Timothy H Moran; Donghai Wu; Guangjing Zhu; Gary D Lopaschuk
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9691-6.
2011: Christian Rueda-Clausen; Jude S Morton; Gary D Lopaschuk; Sandra T Davidge
Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia/reperfusion.
Cardiovascular research 2011;90(2):285-94.
2011: Kari T Chambers; Teresa C Leone; Nandakumar Sambandam; Attila Kovacs; Cory S Wagg; Gary D Lopaschuk; Brian N Finck; Daniel P Kelly
Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response.
The Journal of biological chemistry 2011;286(13):11155-62.
2011: Wendy Keung; Virgilio J J Cadete; Arivazhagan Palaniyappan; Amissa Jablonski; Melanie Fischer; Gary D Lopaschuk
Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet.
Journal of cardiovascular pharmacology 2011;57(1):103-13.
2011: Fatima Mraiche; Cory S Wagg; Gary D Lopaschuk; Larry Fliegel
Elevated levels of activated NHE1 protect the myocardium and improve metabolism following ischemia/reperfusion injury.
Journal of molecular and cellular cardiology 2011;50(1):157-64.
2011: Liyan Zhang; John R Ussher; Tatsujiro Oka; Virgilio J J Cadete; Cory Wagg; Gary D Lopaschuk
Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation.
Cardiovascular research 2011;89(1):148-56.
2010: Vijay Kandalam; Ratnadeep Basu; Thomas Abraham; Xiuhua Wang; Ahmed Awad; Wei Wang; Gary D Lopaschuk; Nobuyo Maeda; Gavin Y Oudit; Zamaneh Kassiri
Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2010;299(4):H1012-23.
2010: Jagdip S Jaswal; Chad R Lund; Wendy Keung; Donna L Beker; Ivan M Rebeyka; Gary D Lopaschuk
Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts.
American journal of physiology. Heart and circulatory physiology 2010;299(4):H1135-45.
2010: John R Ussher; Timothy R Koves; Virgilio J J Cadete; Liyan Zhang; Jagdip S Jaswal; Suzanne J Swyrd; David G Lopaschuk; Spencer D Proctor; Wendy Keung; Deborah M Muoio; Gary D Lopaschuk
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
Diabetes 2010;59(10):2453-64.
2010: Vernon W Dolinsky; Jude S Morton; Tatsujiro Oka; Isabelle Robillard-Frayne; Mariel Bagdan; Gary D Lopaschuk; Christine Des Rosiers; Kenneth Walsh; Sandra T Davidge; Jason R B Dyck
Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat.
Hypertension 2010;56(3):412-21.
2010: Lianguo Wang; Kerry W S Ko; Eliana Lucchinetti; Liyan Zhang; Heinz Troxler; Martin Hersberger; Mohamed A Omar; Elena I Posse de Chaves; Gary D Lopaschuk; Alexander S Clanachan; Michael Zaugg
Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation: CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift.
Anesthesiology 2010;113(3):541-51.
2010: Gopinath Sutendra; Sebastien Bonnet; Gael Rochefort; Alois Haromy; Karalyn D Folmes; Gary D Lopaschuk; Jason R B Dyck; Evangelos D Michelakis
Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.
Science translational medicine 2010;2(44):44ra58.
2010: Gary D Lopaschuk; Jagdip S Jaswal
Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation.
Journal of cardiovascular pharmacology 2010;56(2):130-40.
2010: Jessica M Scott; Ben T A Esch; Mark J Haykowsky; Ian Paterson; Darren E R Warburton; Kira Chow; June Cheng Baron; Gary D Lopaschuk; Richard B Thompson
Effects of high intensity exercise on biventricular function assessed by cardiac magnetic resonance imaging in endurance trained and normally active individuals.
The American journal of cardiology 2010;106(2):278-83.
2010: Niels Jessen; Ho-Jin Koh; Clifford D Folmes; Cory Wagg; Nobuharu Fujii; Bo Løfgren; Cordula M Wolf; Charles I Berul; Michael F Hirshman; Gary D Lopaschuk; Laurie J Goodyear
Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.
Biochimica et biophysica acta 2010;1802(7-8):593-600.
2010: Gary D Lopaschuk; John R Ussher; Jagdip S Jaswal
Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.
Pharmacological reviews 2010;62(2):237-64.
2010: Wenyan Niu; Philip J Bilan; Shuhei Ishikura; Jonathan D Schertzer; Ariel Contreras-Ferrat; Zhengxiang Fu; Jie Liu; Shlomit Boguslavsky; Kevin P Foley; Zhi Liu; Jinru Li; Guilan Chu; Thomas Panakkezhum; Gary D Lopaschuk; Sergio Lavandero; Zhi Yao; Amira Klip
Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells.
American journal of physiology. Endocrinology and metabolism 2010;298(5):E1058-71.
2010: Masayoshi Ito; Jagdip S Jaswal; Victoria H Lam; Tatsujiro Oka; Liyan Zhang; Donna L Beker; Gary D Lopaschuk; Ivan M Rebeyka
High levels of fatty acids increase contractile function of neonatal rabbit hearts during reperfusion following ischemia.
American journal of physiology. Heart and circulatory physiology 2010;298(5):H1426-37.
2010: Rui A Carvalho; Rui P B Sousa; Virgilio J J Cadete; Gary D Lopaschuk; Carlos M Palmeira; James A Bjork; Kendall B Wallace
Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.
Toxicology 2010;270(2-3):92-8.
2010: Clifford Dl Folmes; Grzegorz Sawicki; Virgilio Jj Cadete; Grant Masson; Amy J Barr; Gary D Lopaschuk
Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury.
Proteome science 2010;8():38.
2010: Gary D Lopaschuk; John R Ussher; Clifford D L Folmes; Jagdip S Jaswal; William C Stanley
Myocardial fatty acid metabolism in health and disease.
Physiological reviews 2010;90(1):207-58.
2010: Lin Piao; Yong-Hu Fang; Virgilio J J Cadete; Christian Wietholt; Dalia Urboniene; Peter T Toth; Glenn Marsboom; Hannah J Zhang; Idith Haber; Jalees Rehman; Gary D Lopaschuk; Stephen L Archer
The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.
Journal of molecular medicine (Berlin, Germany) 2010;88(1):47-60.
2010: Liyan Zhang; Wendy Keung; Victor Samokhvalov; Wei Wang; Gary D Lopaschuk
Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle.
Biochimica et biophysica acta 2010;1801(1):1-22.
2009: Ratnadeep Basu; Gavin Y Oudit; Xiuhua Wang; Liyan Zhang; John R Ussher; Gary D Lopaschuk; Zamaneh Kassiri
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
American journal of physiology. Heart and circulatory physiology 2009;297(6):H2096-108.
2009: Xiang Wang; Tatsujiro Oka; Fung L Chow; Stephan B Cooper; Jeff Odenbach; Gary D Lopaschuk; Zamaneh Kassiri; Carlos Fernandez-Patron
Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.
Hypertension 2009;54(3):575-82.
2009: John R Ussher; Jagdip S Jaswal; Cory S Wagg; Heather E Armstrong; David G Lopaschuk; Wendy Keung; Gary D Lopaschuk
Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E349-57.
2009: John R Ussher; Timothy R Koves; Jagdip S Jaswal; Liyan Zhang; Olga Ilkayeva; Jason R B Dyck; Deborah M Muoio; Gary D Lopaschuk
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
Diabetes 2009;58(8):1766-75.
2009: Clifford D L Folmes; Cory S Wagg; Mei Shen; Alexander S Clanachan; Rong Tian; Gary D Lopaschuk
Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H313-21.
2009: Clifford D L Folmes; Daniel Sowah; Alexander S Clanachan; Gary D Lopaschuk
High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.
Journal of molecular and cellular cardiology 2009;47(1):142-8.
2009: Jie Yan; Martin E Young; Lei Cui; Gary D Lopaschuk; Ronglih Liao; Rong Tian
Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.
Circulation 2009;119(21):2818-28.
2009: Xiang Wang; Fung Lan Chow; Tatsujiro Oka; Li Hao; Ana Lopez-Campistrous; Sandra Kelly; Stephan Cooper; Jeffrey Odenbach; Barry A Finegan; Richard Schulz; Zamaneh Kassiri; Gary D Lopaschuk; Carlos Fernandez-Patron
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Circulation 2009;119(18):2480-9.
2009: Theodore P Abraham; Michelle Jones; Katarzyna Kazmierczak; Hsin-Yueh Liang; Aurelio C Pinheiro; Cory S Wagg; Gary D Lopaschuk; Danuta Szczesna-Cordary
Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.
Cardiovascular research 2009;82(1):84-92.
2009: John R Ussher; Gary D Lopaschuk
Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion.
Basic research in cardiology 2009;104(2):203-10.
2008: Lianguo Wang; Gary D Lopaschuk; Alexander S Clanachan
H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation.
Journal of molecular and cellular cardiology 2008;45(6):787-95.
2008: Michael A Yatscoff; Jagdip S Jaswal; Meghan R Grant; Rachel Greenwood; Trish Lukat; Donna L Beker; Ivan M Rebeyka; Gary D Lopaschuk
Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart.
Pediatric research 2008;64(6):643-7.
2008: Justyna Fert-Bober; Grzegorz Sawicki; Gary D Lopaschuk; Po-Yin Cheung
Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets.
Molecular and cellular biochemistry 2008;318(1-2):13-21.
2008: Gary D Lopaschuk
AMP-activated protein kinase control of energy metabolism in the ischemic heart.
International journal of obesity (2005) 2008;32 Suppl 4():S29-35.
2008: Biao Lei; David J Chess; Wendy Keung; Karen M O'Shea; Gary D Lopaschuk; William C Stanley
Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK.
Journal of molecular and cellular cardiology 2008;45(3):404-10.
2008: Ramzi J Khairallah; Maya Khairallah; Roselle Gélinas; Bertrand Bouchard; Martin E Young; Bruce G Allen; Gary D Lopaschuk; Christian Deschepper; Christine Des Rosiers
Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation.
Journal of molecular and cellular cardiology 2008;45(2):230-9.
2008: Gary D Lopaschuk; Daniel P Kelly
Signalling in cardiac metabolism.
Cardiovascular research 2008;79(2):205-7.
2008: John R Ussher; Gary D Lopaschuk
The malonyl CoA axis as a potential target for treating ischaemic heart disease.
Cardiovascular research 2008;79(2):259-68.
2008: Lufang Zhou; Hazel Huang; Celvie L Yuan; Wendy Keung; Gary D Lopaschuk; William C Stanley
Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H954-60.
2008: Timothy R Koves; John R Ussher; Robert C Noland; Dorothy H Slentz; Merrie Mosedale; Olga Ilkayeva; James R Bain; Robert Stevens; Jason R B Dyck; Christopher B Newgard; Gary D Lopaschuk; Deborah M Muoio
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Cell metabolism 2008;7(1):45-56.
2007: Danuta Szczesna-Cordary; Michelle Jones; Jeffrey R Moore; James Watt; W Glenn L Kerrick; Yuanyuan Xu; Ying Wang; Cory Wagg; Gary D Lopaschuk
Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(14):3974-85.
2007: Wei Wang; Gary D Lopaschuk
Metabolic therapy for the treatment of ischemic heart disease: reality and expectations.
Expert review of cardiovascular therapy 2007;5(6):1123-34.
2007: Su Gao; Kimberly P Kinzig; Susan Aja; Karen A Scott; Wendy Keung; Sandra Kelly; Ken Strynadka; Shigeru Chohnan; Wanli Smith; Kellie L K Tamashiro; Ellen E Ladenheim; Gabriele V Ronnett; Yajun Tu; Morris J Birnbaum; Gary D Lopaschuk; Timothy H Moran
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17358-63.
2007: Gareth A Wallis; Anne L Friedlander; Kevin A Jacobs; Michael A Horning; Jill A Fattor; Eugene E Wolfel; Gary D Lopaschuk; George A Brooks
Substantial working muscle glycerol turnover during two-legged cycle ergometry.
American journal of physiology. Endocrinology and metabolism 2007;293(4):E950-7.
2007: Charles T Putman; Karen J B Martins; Maria E Gallo; Gary D Lopaschuk; Jean A Pearcey; Ian M MacLean; Ryan J Saranchuk; Dirk Pette
Alpha-catalytic subunits of 5'AMP-activated protein kinase display fiber-specific expression and are upregulated by chronic low-frequency stimulation in rat muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1325-34.
2007: Arzu Onay Besikci; Cory Wagg; Timothy P Lopaschuk; Wendy Keung; Gary D Lopaschuk
Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts.
Basic research in cardiology 2007;102(5):436-44.
2007: Gary D Lopaschuk; Clifford D L Folmes; William C Stanley
Cardiac energy metabolism in obesity.
Circulation research 2007;101(4):335-47.
2007: Anna Lam; Gary D Lopaschuk
Anti-anginal effects of partial fatty acid oxidation inhibitors.
Current opinion in pharmacology 2007;7(2):179-85.
2007: Anna A Noga; Carrie-Lynn M Soltys; Amy J Barr; Suzanne Kovacic; Gary D Lopaschuk; Jason R B Dyck
Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy.
American journal of physiology. Heart and circulatory physiology 2007;292(3):H1460-9.
2007: Clifford D L Folmes; Gary D Lopaschuk
Role of malonyl-CoA in heart disease and the hypothalamic control of obesity.
Cardiovascular research 2007;73(2):278-87.
2007: Maysa Taha; Gary D Lopaschuk
Alterations in energy metabolism in cardiomyopathies.
Annals of medicine 2007;39(8):594-607.
2007: Sebastien Bonnet; Stephen L Archer; Joan Allalunis-Turner; Alois Haromy; Christian Beaulieu; Richard Thompson; Christopher T Lee; Gary D Lopaschuk; Lakshmi Puttagunta; Sandra Bonnet; Gwyneth Harry; Kyoko Hashimoto; Christopher J Porter; Miguel Andrade; Bernard Thebaud; Evangelos D Michelakis
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Cancer cell 2007;11(1):37-51.
2006: Gary D Lopaschuk; William C Stanley
Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(6):433-9.
2006: Jason R B Dyck; Teresa A Hopkins; Sebastien Bonnet; Evangelos D Michelakis; Martin E Young; Miho Watanabe; Yosuke Kawase; Kou-ichi Jishage; Gary D Lopaschuk
Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.
Circulation 2006;114(16):1721-8.
2006: Gary D Lopaschuk
Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.
Seminars in cardiothoracic and vascular anesthesia 2006;10(3):228-30.
2006: Gary D Lopaschuk
Cardiac energy metabolism alterations in angiotensin II induced hypertrophy.
Journal of molecular and cellular cardiology 2006;41(3):418-20.
2006: Jie-Fei Cheng; Yujin Huang; Richard Penuliar; Masahiro Nishimoto; Larry Liu; Thomas Arrhenius; Guang Yang; Eoin O'leary; Miguel Barbosa; Rick Barr; Jason R B Dyck; Gary D Lopaschuk; Alex M Nadzan
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
Journal of medicinal chemistry 2006;49(14):4055-8.
2006: Clifford D L Folmes; Alexander S Clanachan; Gary D Lopaschuk
Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia.
Circulation research 2006;99(1):61-8.
2006: Jason R B Dyck; Gary D Lopaschuk
AMPK alterations in cardiac physiology and pathology: enemy or ally?
The Journal of physiology 2006;574(Pt 1):95-112.
2006: Jie-Fei Cheng; Chi Ching Mak; Yujin Huang; Richard Penuliar; Masahiro Nishimoto; Lin Zhang; Mi Chen; David Wallace; Thomas Arrhenius; Donald Chu; Guang Yang; Miguel Barbosa; Rick Barr; Jason R B Dyck; Gary D Lopaschuk; Alex M Nadzan
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(13):3484-8.
2006: Cheryl A Collier; Clinton R Bruce; Angela C Smith; Gary D Lopaschuk; David J Dyck
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E182-9.
2006: Gabriele Fragasso; Chiara Montano; Gianluca Perseghin; Altin Palloshi; Giliola Calori; Guido Lattuada; Silvia Oggionni; Giorgio Bassanelli; Massimo Locatelli; Gary D Lopaschuk; Alberto Margonato
The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.
American heart journal 2006;151(6):1238.e1-8.
2006: Jie-Fei Cheng; Mi Chen; David Wallace; Souvothy Tith; Masayuki Haramura; Bin Liu; Chi Ching Mak; Thomas Arrhenius; Sean Reily; Steven Brown; Vicki Thorn; Charles Harmon; Rick Barr; Jason R B Dyck; Gary D Lopaschuk; Alex M Nadzan
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Journal of medicinal chemistry 2006;49(5):1517-25.
2006: Wan Huang; Nikolas Dedousis; Archana Bandi; Gary D Lopaschuk; Robert M O'Doherty
Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo.
Endocrinology 2006;147(3):1480-7.
2006: Timothy R DeGrado; Mehmet T Kitapci; Shuyan Wang; Jun Ying; Gary D Lopaschuk
Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(1):173-81.
2006: Nandakumar Sambandam; Dominique Morabito; Cory Wagg; Brian N Finck; Daniel P Kelly; Gary D Lopaschuk
Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H87-95.
2005: William C Stanley; Eric E Morgan; Hazel Huang; Tracy A McElfresh; Joseph P Sterk; Isidore C Okere; Margaret P Chandler; Jiefei Cheng; Jason R B Dyck; Gary D Lopaschuk
Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2304-9.
2005: Kristen L King; Isidore C Okere; Naveen Sharma; Jason R B Dyck; Aneta E Reszko; Tracy A McElfresh; Janos Kerner; Margaret P Chandler; Gary D Lopaschuk; William C Stanley
Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1033-7.
2005: William C Stanley; Fabio A Recchia; Gary D Lopaschuk
Myocardial substrate metabolism in the normal and failing heart.
Physiological reviews 2005;85(3):1093-129.
2005: Abdul Al-Hesayen; Eduardo R Azevedo; John S Floras; Shauna Hollingshead; Gary D Lopaschuk; John D Parker
Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization.
European journal of heart failure 2005;7(4):618-23.
2005: Clifford D L Folmes; Alexander S Clanachan; Gary D Lopaschuk
Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis.
Current atherosclerosis reports 2005;7(1):63-70.
2005: Judith Y Altarejos; Masayuki Taniguchi; Alexander S Clanachan; Gary D Lopaschuk
Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase.
The Journal of biological chemistry 2005;280(1):183-90.
2005: Sonal S Sheth; Lawrence W Castellani; Soumya Chari; Cory Wagg; Christopher K Thipphavong; Jackie S Bodnar; Peter Tontonoz; Alan D Attie; Gary D Lopaschuk; Aldons J Lusis
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Journal of lipid research 2005;46(1):123-34.
2004: Tong Dai; George A Abou-Rjaily; Qusai Y Al-Share'; Yan Yang; Mats A Fernström; Anthony M Deangelis; Abraham D Lee; Lawrence Sweetman; Antonino Amato; Marzia Pasquali; Gary D Lopaschuk; Sandra K Erickson; Sonia M Najjar
Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice.
The Journal of biological chemistry 2004;279(43):45155-61.
2004: Arzu Onay Besikci; Judith Y Altarejos; Gary D Lopaschuk
gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts.
The Journal of biological chemistry 2004;279(43):44320-6.
2004: Aneta E Reszko; Takhar Kasumov; France David; Katherine R Thomas; Kathryn A Jobbins; Jie-Fei Cheng; Gary D Lopaschuk; Jason R B Dyck; Mireya Diaz; Christine Des Rosiers; William C Stanley; Henri Brunengraber
Regulation of malonyl-CoA concentration and turnover in the normal heart.
The Journal of biological chemistry 2004;279(33):34298-301.
2004: Gary D Lopaschuk
Glutamate transport in the heart: lessons learned from the brain.
Journal of molecular and cellular cardiology 2004;37(1):5-6.
2004: Nandakumar Sambandam; Michael Steinmetz; Angel Chu; Judith Y Altarejos; Jason R B Dyck; Gary D Lopaschuk
Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique.
European journal of biochemistry / FEBS 2004;271(13):2831-40.
2004: Hernando Leon; Laura L Atkinson; Jolanta Sawicka; Ken Strynadka; Gary D Lopaschuk; Richard Schulz
Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts.
Canadian journal of physiology and pharmacology 2004;82(6):409-16.
2004: Jason R B Dyck; Jie-Fei Cheng; William C Stanley; Rick Barr; Margaret P Chandler; Steven Brown; David Wallace; Thomas Arrhenius; Charles Harmon; Guang Yang; Alex M Nadzan; Gary D Lopaschuk
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.
Circulation research 2004;94(9):e78-84.
2004: Demin Zhou; Phoebe Yuen; Donald Chu; Vicki Thon; Steve McConnell; Steven Brown; Andria Tsang; Michael Pena; Anna Russell; Jie-Fei Cheng; Alex M Nadzan; Miguel S Barbosa; Jason R B Dyck; Gary D Lopaschuk; Guang Yang
Expression, purification, and characterization of human malonyl-CoA decarboxylase.
Protein expression and purification 2004;34(2):261-9.
2004: Michael Kuang; Maria Febbraio; Cory Wagg; Gary D Lopaschuk; Jason R B Dyck
Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia.
Circulation 2004;109(12):1550-7.
2004: Gary D Lopaschuk
Targets for modulation of fatty acid oxidation in the heart.
Current opinion in investigational drugs (London, England : 2000) 2004;5(3):290-4.
2004: Toshiyuki Fukao; Gary D Lopaschuk; Grant A Mitchell
Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.
Prostaglandins, leukotrienes, and essential fatty acids 2004;70(3):243-51.
2004: Paul W Armstrong; Christina Ezekowitz; Evangelos D Michelakis; Todd Anderson; Stephen Archer; William Ghali; Robert Hayward; Louise Jensen; Gary D Lopaschuk; Robert Sheldon
Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH).
Clinical and investigative medicine. Médecine clinique et experimentale 2004;27(1):33-41.
2003: Jeremy Bamford; Gary D Lopaschuk; Ian M MacLean; Marcia L Reinhart; Walter T Dixon; Charles T Putman
Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles.
Canadian journal of physiology and pharmacology 2003;81(11):1072-82.
2003: Gabriele Fragasso; P M Piatti Md; Lucilla D Monti; Altin Palloshi; Emanuela Setola; Patrizia Puccetti; Giliola Calori; Gary D Lopaschuk; Alberto Margonato
Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
American heart journal 2003;146(5):E18.
2003: William C Stanley; Steven R Meadows; Krista M Kivilo; Bridgette A Roth; Gary D Lopaschuk
beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content.
American journal of physiology. Heart and circulatory physiology 2003;285(4):H1626-31.
2003: Gary D Lopaschuk; Rick Barr; Panakkezhum D Thomas; Jason R B Dyck
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
Circulation research 2003;93(3):e33-7.
2003: Teresa A Hopkins; Mary C Sugden; Mark J Holness; Ray Kozak; Jason R B Dyck; Gary D Lopaschuk
Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H270-6.
2003: Nandakumar Sambandam; Gary D Lopaschuk
AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart.
Progress in lipid research 2003;42(3):238-56.
2003: Laura L Atkinson; Ray Kozak; Sandra Elizabeth Kelly; Arzu Onay Besikci; James C Russell; Gary D Lopaschuk
Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats.
American journal of physiology. Endocrinology and metabolism 2003;284(5):E923-30.
2003: Teresa A Hopkins; Jason R B Dyck; Gary D Lopaschuk
AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart.
Biochemical Society transactions 2003;31(Pt 1):207-12.
2003: Arzu Onay-Besikci; Fiona M Campbell; Teresa A Hopkins; Jason R B Dyck; Gary D Lopaschuk; Arzu Onay Besikci
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H283-9.
2002: Jason R B Dyck; Gary D Lopaschuk
Malonyl CoA control of fatty acid oxidation in the ischemic heart.
Journal of molecular and cellular cardiology 2002;34(9):1099-109.
2002: Gary D Lopaschuk; Lionel Henry Opie
Introduction to JMCC symposium on myocardial energy metabolism in health and disease.
Journal of molecular and cellular cardiology 2002;34(9):1075-6.
2002: Laura L Atkinson; Melanie A Fischer; Gary D Lopaschuk
Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis.
The Journal of biological chemistry 2002;277(33):29424-30.
2002: Juan Carlos Osorio; William C Stanley; Axel Linke; michele castellari; Quy N Diep; Ashish R Panchal; Thomas H Hintze; Gary D Lopaschuk; Fabio A Recchia
Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure.
Circulation 2002;106(5):606-12.
2002: Laura L Atkinson; Sandra Elizabeth Kelly; James C Russell; Jacob Bar-Tana; Gary D Lopaschuk
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.
Diabetes 2002;51(5):1548-55.
2002: Hon Sing Leong; Mark Grist; Hannah L Parsons; Richard B Wambolt; Gary D Lopaschuk; Roger Brownsey; Michael F Allard
Accelerated rates of glycolysis in the hypertrophied heart: are they a methodological artifact?
American journal of physiology. Endocrinology and metabolism 2002;282(5):E1039-45.
2002: Nandakumar Sambandam; Gary D Lopaschuk; Roger Brownsey; Michael F Allard
Energy metabolism in the hypertrophied heart.
Heart failure reviews 2002;7(2):161-73.
2002: Gary D Lopaschuk
Metabolic abnormalities in the diabetic heart.
Heart failure reviews 2002;7(2):149-59.
2002: Yi Xu; Dinender Kumar; Jason R B Dyck; William R Ford; Alexander S Clanachan; Gary D Lopaschuk; Bodh I Jugdutt
AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1206-15.
2002: Que Liu; John C Docherty; John C T Rendell; Alexander S Clanachan; Gary D Lopaschuk
High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation.
Journal of the American College of Cardiology 2002;39(4):718-25.
2002: Fiona M Campbell; Ray Kozak; Alese Wagner; Judith Y Altarejos; Jason R B Dyck; Darrell D Belke; David L Severson; Daniel P Kelly; Gary D Lopaschuk
A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase.
The Journal of biological chemistry 2002;277(6):4098-103.
2002: Evangelos D Michelakis; M Sean McMurtry; Xi-Chen Wu; Jason R B Dyck; Rohit Moudgil; Teresa A Hopkins; Gary D Lopaschuk; Lakshmi Puttagunta; Ross Waite; Stephen L Archer
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Circulation 2002;105(2):244-50.
2002: Gary D Lopaschuk; Ivan M Rebeyka; Michael F Allard
Metabolic modulation: a means to mend a broken heart.
Circulation 2002;105(2):140-2.
2002: Brian N Finck; John J Lehman; Teresa C Leone; Michael J Welch; Michael J Bennett; Attila Kovacs; Xianlin Han; Richard W Gross; Ray Kozak; Gary D Lopaschuk; Daniel P Kelly
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
The Journal of clinical investigation 2002;109(1):121-30.
2002: Fabio A Recchia; Juan Carlos Osorio; Margaret P Chandler; Xiaobin Xu; Ashish R Panchal; Gary D Lopaschuk; Thomas H Hintze; William C Stanley
Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs.
American journal of physiology. Endocrinology and metabolism 2002;282(1):E197-206.
2001: Sarah L Longnus; Richard B Wambolt; R L Barr; Gary D Lopaschuk; Michael F Allard
Regulation of myocardial fatty acid oxidation by substrate supply.
American journal of physiology. Heart and circulatory physiology 2001;281(4):H1561-7.
2001: M Taniguchi; C Wilson; C A Hunter; Daniel J Pehowich; Alexander S Clanachan; Gary D Lopaschuk
Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1762-9.
2001: Gary D Lopaschuk
Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?
Coronary artery disease 2001;12 Suppl 1():S8-11.
2001: Gary D Lopaschuk
Malonyl CoA control of fatty acid oxidation in the diabetic rat heart.
Advances in experimental medicine and biology 2001;498():155-65.
2000: Richard B Wambolt; Gary D Lopaschuk; Roger Brownsey; Michael F Allard
Dichloroacetate improves postischemic function of hypertrophied rat hearts.
Journal of the American College of Cardiology 2000;36(4):1378-85.
2000: William R Ford; Bodh I Jugdutt; Gary D Lopaschuk; Richard Schulz; Alexander S Clanachan
Influence of beta-adrenoceptor tone on the cardioprotective efficacy of adenosine A(1) receptor activation in isolated working rat hearts.
British journal of pharmacology 2000;131(3):537-45.
2000: Jason R B Dyck; Luc G Berthiaume; Panakkezhum D Thomas; PF Kantor; Amy J Barr; Rick Barr; D Singh; Teresa A Hopkins; N Voilley; Marc Prentki; Gary D Lopaschuk
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism.
The Biochemical journal 2000;350 Pt 2():599-608.
2000: J Sakamoto; RL Barr; Katherine M Kavanagh; Gary D Lopaschuk
Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1196-204.
2000: PF Kantor; A Lucien; Ray Kozak; Gary D Lopaschuk
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Circulation research 2000;86(5):580-8.
2000: RL Barr; Gary D Lopaschuk
Methodology for measuring in vitro/ex vivo cardiac energy metabolism.
Journal of pharmacological and toxicological methods 2000;43(2):141-52.
2000: Gary D Lopaschuk
Regulation of carbohydrate metabolism in ischemia and reperfusion.
American heart journal 2000;139(2 Pt 3):S115-9.
1999: Heather Fraser; Gary D Lopaschuk; Alexander S Clanachan
Alteration of glycogen and glucose metabolism in ischaemic and post-ischaemic working rat hearts by adenosine A1 receptor stimulation.
British journal of pharmacology 1999;128(1):197-205.
1999: PF Kantor; Jason R B Dyck; Gary D Lopaschuk
Fatty acid oxidation in the reperfused ischemic heart.
The American journal of the medical sciences 1999;318(1):3-14.
1999: N Voilley; Raphael Roduit; R Vicaretti; C Bonny; Gerard Waeber; Jason R B Dyck; Gary D Lopaschuk; Marc Prentki
Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase.
The Biochemical journal 1999;340 ( Pt 1)():213-7.
1999: PF Kantor; Murray A Robertson; J Y Coe; Gary D Lopaschuk
Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism.
Journal of the American College of Cardiology 1999;33(6):1724-34.
1999: Jason R B Dyck; N Kudo; Amy J Barr; S P Davies; D G Hardie; Gary D Lopaschuk
Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase.
European journal of biochemistry / FEBS 1999;262(1):184-90.
1999: Richard B Wambolt; SL Henning; Dean R English; Yulia Dyachkova; Gary D Lopaschuk; Michael F Allard
Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia.
Journal of molecular and cellular cardiology 1999;31(3):493-502.
1998: Gary D Lopaschuk
[Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism].
Presse médicale (Paris, France : 1983) 1998;27(39):2100-4.
1998: Jason R B Dyck; Amy J Barr; RL Barr; Pappachan Kolattukudy; Gary D Lopaschuk
Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation.
The American journal of physiology 1998;275(6 Pt 2):H2122-9.
1998: A O Makinde; PF Kantor; Gary D Lopaschuk
Maturation of fatty acid and carbohydrate metabolism in the newborn heart.
Molecular and cellular biochemistry 1998;188(1-2):49-56.
1998: Heather Fraser; Gary D Lopaschuk; Alexander S Clanachan
Assessment of glycogen turnover in aerobic, ischemic, and reperfused working rat hearts.
The American journal of physiology 1998;275(5 Pt 2):H1533-41.
1998: Yoshikatsu Saiki; Gary D Lopaschuk; K Dodge; Kazuhiro Yamaya; C Morgan; Ivan M Rebeyka
Pyruvate augments mechanical function via activation of the pyruvate dehydrogenase complex in reperfused ischemic immature rabbit hearts.
The Journal of surgical research 1998;79(2):164-9.
1998: Gary D Lopaschuk
Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism.
The American journal of cardiology 1998;82(5A):14K-17K.
1998: Q Liu; Alexander S Clanachan; Gary D Lopaschuk
Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts.
The American journal of physiology 1998;275(3 Pt 1):E392-9.
1998: William R Ford; Gary D Lopaschuk; Richard Schulz; Alexander S Clanachan
K(ATP)-channel activation: effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation.
British journal of pharmacology 1998;124(4):639-46.
1998: William R Ford; Alexander S Clanachan; Gary D Lopaschuk; Richard Schulz; Bodh I Jugdutt
Intrinsic ANG II type 1 receptor stimulation contributes to recovery of postischemic mechanical function.
The American journal of physiology 1998;274(5 Pt 2):H1524-31.
1998: Darrell D Belke; Lawrence C H Wang; Gary D Lopaschuk
Acetyl-CoA carboxylase control of fatty acid oxidation in hearts from hibernating Richardson's ground squirrels.
Biochimica et biophysica acta 1998;1391(1):25-36.
1998: Jason R B Dyck; Gary D Lopaschuk
Glucose metabolism, H+ production and Na+/H+-exchanger mRNA levels in ischemic hearts from diabetic rats.
Molecular and cellular biochemistry 1998;180(1-2):85-93.
1997: J Gamble; Gary D Lopaschuk
Insulin inhibition of 5' adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation.
Metabolism: clinical and experimental 1997;46(11):1270-4.
1997: B O Schönekess; Michael F Allard; SL Henning; Richard B Wambolt; Gary D Lopaschuk
Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart.
Circulation research 1997;81(4):540-9.
1997: RL Barr; Gary D Lopaschuk
Direct measurement of energy metabolism in the isolated working rat heart.
Journal of pharmacological and toxicological methods 1997;38(1):11-7.
1997: Gary D Lopaschuk
Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia.
The American journal of cardiology 1997;80(3A):11A-16A.
1997: Michael F Allard; SL Henning; Richard B Wambolt; S R Granleese; Dean R English; Gary D Lopaschuk
Glycogen metabolism in the aerobic hypertrophied rat heart.
Circulation 1997;96(2):676-82.
1997: Gary D Lopaschuk
Advantages and limitations of experimental techniques used to measure cardiac energy metabolism.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1997;4(4):316-28.
1997: Gary D Lopaschuk; RL Barr
Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart.
Molecular and cellular biochemistry 1997;172(1-2):137-47.
1997: William C Stanley; Gary D Lopaschuk; J G McCormack
Regulation of energy substrate metabolism in the diabetic heart.
Cardiovascular research 1997;34(1):25-33.
1997: A O Makinde; J Gamble; Gary D Lopaschuk
Upregulation of 5'-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit.
Circulation research 1997;80(4):482-9.
1997: Darrell D Belke; Lawrence C H Wang; Gary D Lopaschuk
Effects of hypothermia on energy metabolism in rat and Richardson's ground squirrel hearts.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(4):1210-8.
1997: Richard Schulz; K L Dodge; Gary D Lopaschuk; Alexander S Clanachan
Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency.
The American journal of physiology 1997;272(3 Pt 2):H1212-9.
1996: Barry A Finegan; Manoj Gandhi; Gary D Lopaschuk; Alexander S Clanachan
Antecedent ischemia reverses effects of adenosine on glycolysis and mechanical function of working hearts.
The American journal of physiology 1996;271(5 Pt 2):H2116-25.
1996: B Liu; Alexander S Clanachan; Richard Schulz; Gary D Lopaschuk
Cardiac efficiency is improved after ischemia by altering both the source and fate of protons.
Circulation research 1996;79(5):940-8.
1996: B O Schönekess; Michael F Allard; Gary D Lopaschuk
Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts.
The American journal of physiology 1996;271(2 Pt 2):H798-805.
1996: T Itoi; Gary D Lopaschuk
Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated Bi-ventricular working hearts from immature rabbits.
Journal of molecular and cellular cardiology 1996;28(7):1501-14.
1996: N Kudo; J G Gillespie; L Kung; L A Witters; Richard Schulz; Alexander S Clanachan; Gary D Lopaschuk
Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia.
Biochimica et biophysica acta 1996;1301(1-2):67-75.
1996: P M Olley; J Kasserra; R Kozak; Gary D Lopaschuk
Synergism between prostaglandin E2 and isoproterenol in stimulating glucose oxidation in the heart.
Canadian journal of physiology and pharmacology 1996;74(5):590-7.
1996: Barry A Finegan; Gary D Lopaschuk; Manoj Gandhi; Alexander S Clanachan
Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A1 receptor stimulation during reperfusion following ischaemia.
British journal of pharmacology 1996;118(2):355-63.
1996: SL Henning; Richard B Wambolt; B O Schönekess; Gary D Lopaschuk; Michael F Allard
Contribution of glycogen to aerobic myocardial glucose utilization.
Circulation 1996;93(8):1549-55.
1996: Michael F Allard; Gary D Lopaschuk
Ischemia and reperfusion injury in the hypertrophied heart.
EXS 1996;76():423-41.
1996: B Liu; Z el Alaoui-Talibi; Alexander S Clanachan; Richard Schulz; Gary D Lopaschuk
Uncoupling of contractile function from mitochondrial TCA cycle activity and MVO2 during reperfusion of ischemic hearts.
The American journal of physiology 1996;270(1 Pt 2):H72-80.
1996: J G McCormack; RL Barr; A A Wolff; Gary D Lopaschuk
Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts.
Circulation 1996;93(1):135-42.
1995: B O Schönekess; Michael F Allard; Gary D Lopaschuk
Propionyl L-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency.
European journal of pharmacology 1995;286(2):155-66.
1995: B O Schönekess; P G Brindley; Gary D Lopaschuk
Calcium regulation of glycolysis, glucose oxidation, and fatty acid oxidation in the aerobic and ischemic heart.
Canadian journal of physiology and pharmacology 1995;73(11):1632-40.
1995: Barry A Finegan; Gary D Lopaschuk; Manoj Gandhi; Alexander S Clanachan
Ischemic preconditioning inhibits glycolysis and proton production in isolated working rat hearts.
The American journal of physiology 1995;269(5 Pt 2):H1767-75.
1995: B O Schönekess; Michael F Allard; Gary D Lopaschuk
Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation.
Circulation research 1995;77(4):726-34.
1995: N Kudo; Amy J Barr; RL Barr; Brenda Osborne; Gary D Lopaschuk
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase.
The Journal of biological chemistry 1995;270(29):17513-20.
1995: T L Broderick; H Arthur Quinney; Gary D Lopaschuk
L-carnitine increases glucose metabolism and mechanical function following ischaemia in diabetic rat heart.
Cardiovascular research 1995;29(3):373-8.
1995: Richard Schulz; D L Panas; R Catena; S Moncada; P M Olley; Gary D Lopaschuk
The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha.
British journal of pharmacology 1995;114(1):27-34.
1994: Ruth L Collins-Nakai; D Noseworthy; Gary D Lopaschuk
Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism.
The American journal of physiology 1994;267(5 Pt 2):H1862-71.
1994: Terrence J Montague; J DeAlmeida; Gary D Lopaschuk; FX Witkowski; D Walker; Margaret L Ackman; Dennis P Humen; Vladimir Dzavik; K Teo
Enhanced glucose oxidation in exercise-induced myocardial ischemia.
The Canadian journal of cardiology 1994;10(9):913-9.
1994: Gary D Lopaschuk; L A Witters; T Itoi; R Barr; A Barr
Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart.
The Journal of biological chemistry 1994;269(41):25871-8.
1994: M Saddik; Gary D Lopaschuk
Triacylglycerol turnover in isolated working hearts of acutely diabetic rats.
Canadian journal of physiology and pharmacology 1994;72(10):1110-9.
1994: Gary D Lopaschuk; J Gamble
The 1993 Merck Frosst Award. Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart.
Canadian journal of physiology and pharmacology 1994;72(10):1101-9.
1994: Gary D Lopaschuk; Darrell D Belke; J Gamble; T Itoi; B O Schönekess
Regulation of fatty acid oxidation in the mammalian heart in health and disease.
Biochimica et biophysica acta 1994;1213(3):263-76.
1994: Michael F Allard; B O Schönekess; SL Henning; Dean R English; Gary D Lopaschuk
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.
The American journal of physiology 1994;267(2 Pt 2):H742-50.
1994: Gary D Lopaschuk; Ruth L Collins-Nakai; P M Olley; Terrence J Montague; G McNeil; M Gayle; PA Penkoske; Barry A Finegan
Plasma fatty acid levels in infants and adults after myocardial ischemia.
American heart journal 1994;128(1):61-7.
1994: J Gamble; Gary D Lopaschuk
Glycolysis and glucose oxidation during reperfusion of ischemic hearts from diabetic rats.
Biochimica et biophysica acta 1994;1225(2):191-9.
1993: M Saddik; J Gamble; L A Witters; Gary D Lopaschuk
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.
The Journal of biological chemistry 1993;268(34):25836-45.
1993: Gary D Lopaschuk; Jonathan R T Lakey; R Barr; Richard B Wambolt; Alan B R Thomson; M Thomas Clandinin; Ray V Rajotte
Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts.
Canadian journal of physiology and pharmacology 1993;71(12):896-903.
1993: T Itoi; Gary D Lopaschuk
The contribution of glycolysis, glucose oxidation, lactate oxidation, and fatty acid oxidation to ATP production in isolated biventricular working hearts from 2-week-old rabbits.
Pediatric research 1993;34(6):735-41.
1993: Richard Schulz; K D Strynadka; D L Panas; P M Olley; Gary D Lopaschuk
Analysis of myocardial plasmalogen and diacyl phospholipids and their arachidonic acid content using high-performance liquid chromatography.
Analytical biochemistry 1993;213(1):140-6.
1993: T Itoi; L Huang; Gary D Lopaschuk
Glucose use in neonatal rabbit hearts reperfused after global ischemia.
The American journal of physiology 1993;265(2 Pt 2):H427-33.
1993: T L Broderick; H Arthur Quinney; C C Barker; Gary D Lopaschuk
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
Circulation 1993;87(3):972-81.
1993: Barry A Finegan; Gary D Lopaschuk; C S Coulson; Alexander S Clanachan
Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts.
Circulation 1993;87(3):900-8.
1993: G D Mao; Panakkezhum D Thomas; Gary D Lopaschuk; M J Poznansky
Superoxide dismutase (SOD)-catalase conjugates. Role of hydrogen peroxide and the Fenton reaction in SOD toxicity.
The Journal of biological chemistry 1993;268(1):416-20.
1993: Gary D Lopaschuk; Richard B Wambolt; RL Barr
An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.
The Journal of pharmacology and experimental therapeutics 1993;264(1):135-44.
1992: Gary D Lopaschuk; M Saddik; R Barr; L Huang; C C Barker; R A Muzyka
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats.
The American journal of physiology 1992;263(6 Pt 1):E1046-53.
1992: R Wong; Gary D Lopaschuk; G Zhu; D Walker; Diane J Catellier; D Burton; K Teo; Ruth L Collins-Nakai; Terrence J Montague
Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.
Chest 1992;102(6):1716-22.
1992: Gary D Lopaschuk; Ruth L Collins-Nakai; T Itoi
Developmental changes in energy substrate use by the heart.
Cardiovascular research 1992;26(12):1172-80.
1992: Gary D Lopaschuk; M Saddik
The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia.
Molecular and cellular biochemistry 1992;116(1-2):111-6.
1992: Jason R B Dyck; Gary D Lopaschuk; Larry Fliegel
Identification of a small Na+/H+ exchanger-like message in the rabbit myocardium.
FEBS letters 1992;310(3):255-9.
1992: Gary D Lopaschuk; M A Spafford
Differences in myocardial ischemic tolerance between 1- and 7-day-old rabbits.
Canadian journal of physiology and pharmacology 1992;70(10):1315-23.
1992: R Wong; Gary D Lopaschuk; K Teo; D Walker; Diane J Catellier; G Zhu; D Burton; Ruth L Collins-Nakai; Terrence J Montague
In vivo skeletal muscle metabolism during dynamic exercise and recovery: assessment by nuclear magnetic resonance spectroscopy.
The Canadian journal of cardiology 1992;8(8):819-24.
1992: N J Davies; Ray Lovlin; Gary D Lopaschuk
Effect of exogenous fatty acids on reperfusion arrhythmias in isolated working perfused hearts.
The American journal of physiology 1992;262(6 Pt 2):H1796-801.
1992: N J Davies; Richard Schulz; P M Olley; K D Strynadka; D L Panas; Gary D Lopaschuk
Lysoplasmenylethanolamine accumulation in ischemic/reperfused isolated fatty acid-perfused hearts.
Circulation research 1992;70(6):1161-8.
1992: Barry A Finegan; Alexander S Clanachan; C S Coulson; Gary D Lopaschuk
Adenosine modification of energy substrate use in isolated hearts perfused with fatty acids.
The American journal of physiology 1992;262(5 Pt 2):H1501-7.
1992: R W Lerner; Gary D Lopaschuk; R C Catena; P M Olley
[3H]iloprost and prostaglandin E2 compete for the same receptor site on cardiac sarcolemmal membranes.
Biochimica et biophysica acta 1992;1105(2):189-92.
1992: Gary D Lopaschuk; R Barr; Richard B Wambolt
Effects of diltiazem on glycolysis and oxidative metabolism in the ischemic and ischemic/reperfused heart.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1220-8.
1992: T L Broderick; RL Barr; H Arthur Quinney; Gary D Lopaschuk
Acute insulin withdrawal from diabetic BB rats decreases myocardial glycolysis during low-flow ischemia.
Metabolism: clinical and experimental 1992;41(3):332-8.
1992: M Saddik; Gary D Lopaschuk
Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia.
The Journal of biological chemistry 1992;267(6):3825-31.
1992: T L Broderick; H Arthur Quinney; Gary D Lopaschuk
Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart.
The Journal of biological chemistry 1992;267(6):3758-63.
1992: R W Lerner; Gary D Lopaschuk; P M Olley
Prostaglandin E2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein.
Canadian journal of physiology and pharmacology 1992;70(1):77-84.
1991: Gary D Lopaschuk; M A Spafford; D R Marsh
Glycolysis is predominant source of myocardial ATP production immediately after birth.
The American journal of physiology 1991;261(6 Pt 2):H1698-705.
1991: M Saddik; Gary D Lopaschuk
The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A.
Biochimica et biophysica acta 1991;1086(2):217-24.
1991: T A Nicholl; Gary D Lopaschuk; John H McNeill
Effects of free fatty acids and dichloroacetate on isolated working diabetic rat heart.
The American journal of physiology 1991;261(4 Pt 2):H1053-9.
1991: Gary D Lopaschuk; James C Russell
Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(4):1302-8.
1991: M Saddik; Gary D Lopaschuk
Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts.
The Journal of biological chemistry 1991;266(13):8162-70.
1991: N J Davies; J J McVeigh; Gary D Lopaschuk
Effects of TA-3090, a new calcium channel blocker, on myocardial substrate utilization in ischemic and nonischemic isolated working fatty acid-perfused rat hearts.
Circulation research 1991;68(3):807-17.
1990: R W Lerner; Gary D Lopaschuk; P M Olley
High-affinity prostaglandin E receptors attenuate adenylyl cyclase activity in isolated bovine myometrial membrane.
Canadian journal of physiology and pharmacology 1990;68(12):1574-80.
1990: R Wong; N Davies; D Marshall; P Allen; G Zhu; Gary D Lopaschuk; Terrence J Montague
Metabolism of normal skeletal muscle during dynamic exercise to clinical fatigue: in vivo assessment by nuclear magnetic resonance spectroscopy.
The Canadian journal of cardiology 1990;6(9):391-5.
1990: J J McVeigh; Gary D Lopaschuk
Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts.
The American journal of physiology 1990;259(4 Pt 2):H1079-85.
1990: Terrence J Montague; Gary D Lopaschuk; N J Davies
Viral heart disease.
Chest 1990;98(1):190-9.
1990: Gary D Lopaschuk; M A Spafford
Energy substrate utilization by isolated working hearts from newborn rabbits.
The American journal of physiology 1990;258(5 Pt 2):H1274-80.
1990: Gary D Lopaschuk; M A Spafford
Acute insulin withdrawal contributes to ischemic heart failure in spontaneously diabetic BB Wistar rats.
Canadian journal of physiology and pharmacology 1990;68(3):462-6.
1990: Gary D Lopaschuk; M A Spafford; N J Davies; S R Wall
Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia.
Circulation research 1990;66(2):546-53.
1989: S R Wall; Gary D Lopaschuk
Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats.
Biochimica et biophysica acta 1989;1006(1):97-103.
1989: Gary D Lopaschuk
Alterations in myocardial fatty acid metabolism contribute to ischemic injury in the diabetic.
The Canadian journal of cardiology 1989;5(6):315-20.
1989: Gary D Lopaschuk; Marek Michalak; E L Wandler; R W Lerner; T D Piscione; F Coceani; P M Olley
Prostaglandin E receptors in cardiac sarcolemma. Identification and coupling to adenylate cyclase.
Circulation research 1989;65(3):538-45.
1989: Gary D Lopaschuk; M Spafford
Response of isolated working hearts to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow in acutely and chronically diabetic rats.
Circulation research 1989;65(2):378-87.
1989: Gary D Lopaschuk; G F McNeil; J J McVeigh
Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir.
Molecular and cellular biochemistry 1989;88(1-2):175-9.
1988: Gary D Lopaschuk; S R Wall; P M Olley; N J Davies
Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine.
Circulation research 1988;63(6):1036-43.
1987: Gary D Lopaschuk; H Tsang
Metabolism of palmitate in isolated working hearts from spontaneously diabetic "BB" Wistar rats.
Circulation research 1987;61(6):853-8.