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Gary Lopaschuk

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Chemicals & Drugs

Living Beings

Phenomena

Oxidation-Reduction

Disorders

Myocardial Ischemia

Physiology

Procedures

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Publications

TOP 3
Wang Xiang; Oka Tatsujiro; Chow Fung L; Cooper Stephan B; Odenbach Jeff; Lopaschuk Gary D; Kassiri Zamaneh; Fernandez-Patron Carlos
Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.
Ussher John R; Jaswal Jagdip S; Wagg Cory S; Armstrong Heather E; Lopaschuk David G; Keung Wendy; Lopaschuk Gary D
Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.
Ussher John R; Koves Timothy R; Jaswal Jagdip S; Zhang Liyan; Ilkayeva Olga; Dyck Jason R B; Muoio Deborah M; Lopaschuk Gary D
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.

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All Publications

2009: Wang Xiang; Oka Tatsujiro; Chow Fung L; Cooper Stephan B; Odenbach Jeff; Lopaschuk Gary D; Kassiri Zamaneh; Fernandez-Patron Carlos
Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.
Hypertension 2009;54(3):575-82.
2009: Ussher John R; Jaswal Jagdip S; Wagg Cory S; Armstrong Heather E; Lopaschuk David G; Keung Wendy; Lopaschuk Gary D
Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E349-57.
2009: Ussher John R; Koves Timothy R; Jaswal Jagdip S; Zhang Liyan; Ilkayeva Olga; Dyck Jason R B; Muoio Deborah M; Lopaschuk Gary D
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
Diabetes 2009;58(8):1766-75.
2009: Folmes Clifford D L; Wagg Cory S; Shen Mei; Clanachan Alexander S; Tian Rong; Lopaschuk Gary D
Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H313-21.
2009: Folmes Clifford D L; Sowah Daniel; Clanachan Alexander S; Lopaschuk Gary D
High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.
Journal of molecular and cellular cardiology 2009;47(1):142-8.
2009: Yan Jie; Young Martin E; Cui Lei; Lopaschuk Gary D; Liao Ronglih; Tian Rong
Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.
Circulation 2009;119(21):2818-28.
2009: Wang Xiang; Chow Fung Lan; Oka Tatsujiro; Hao Li; Lopez-Campistrous Ana; Kelly Sandra; Cooper Stephan; Odenbach Jeffrey; Finegan Barry A; Schulz Richard; Kassiri Zamaneh; Lopaschuk Gary D; Fernandez-Patron Carlos
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Circulation 2009;119(18):2480-9.
2009: Abraham Theodore P; Jones Michelle; Kazmierczak Katarzyna; Liang Hsin-Yueh; Pinheiro Aurelio C; Wagg Cory S; Lopaschuk Gary D; Szczesna-Cordary Danuta
Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.
Cardiovascular research 2009;82(1):84-92.
2009: Ussher John R; Lopaschuk Gary D
Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion.
Basic research in cardiology 2009;104(2):203-10.
2008: Wang Lianguo; Lopaschuk Gary D; Clanachan Alexander S
H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation.
Journal of molecular and cellular cardiology 2008;45(6):787-95.
2008: Yatscoff Michael A; Jaswal Jagdip S; Grant Meghan R; Greenwood Rachel; Lukat Trish; Beker Donna L; Rebeyka Ivan M; Lopaschuk Gary D
Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart.
Pediatric research 2008;64(6):643-7.
2008: Fert-Bober Justyna; Sawicki Grzegorz; Lopaschuk Gary D; Cheung Po-Yin
Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets.
Molecular and cellular biochemistry 2008;318(1-2):13-21.
2008: Lopaschuk G D
AMP-activated protein kinase control of energy metabolism in the ischemic heart.
International journal of obesity (2005) 2008;32 Suppl 4():S29-35.
2008: Lei Biao; Chess David J; Keung Wendy; O'Shea Karen M; Lopaschuk Gary D; Stanley William C
Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK.
Journal of molecular and cellular cardiology 2008;45(3):404-10.
2008: Khairallah Ramzi J; Khairallah Maya; Gélinas Roselle; Bouchard Bertrand; Young Martin E; Allen Bruce G; Lopaschuk Gary D; Deschepper Christian F; Des Rosiers Christine
Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation.
Journal of molecular and cellular cardiology 2008;45(2):230-9.
2008: Lopaschuk Gary D; Kelly Daniel P
Signalling in cardiac metabolism.
Cardiovascular research 2008;79(2):205-7.
2008: Ussher John R; Lopaschuk Gary D
The malonyl CoA axis as a potential target for treating ischaemic heart disease.
Cardiovascular research 2008;79(2):259-68.
2008: Zhou Lufang; Huang Hazel; Yuan Celvie L; Keung Wendy; Lopaschuk Gary D; Stanley William C
Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H954-60.
2008: Koves Timothy R; Ussher John R; Noland Robert C; Slentz Dorothy; Mosedale Merrie; Ilkayeva Olga; Bain James; Stevens Robert; Dyck Jason R B; Newgard Christopher B; Lopaschuk Gary D; Muoio Deborah M
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Cell metabolism 2008;7(1):45-56.
2007: Szczesna-Cordary Danuta; Jones Michelle; Moore Jeffrey R; Watt James; Kerrick W Glenn L; Xu Yuanyuan; Wang Ying; Wagg Cory; Lopaschuk Gary D
Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(14):3974-85.
2007: Wang Wei; Lopaschuk Gary D
Metabolic therapy for the treatment of ischemic heart disease: reality and expectations.
Expert review of cardiovascular therapy 2007;5(6):1123-34.
2007: Gao Su; Kinzig Kimberly P; Aja Susan; Scott Karen A; Keung Wendy; Kelly Sandra; Strynadka Ken; Chohnan Shigeru; Smith Wanli W; Tamashiro Kellie L K; Ladenheim Ellen E; Ronnett Gabriele V; Tu Yajun; Birnbaum Morris J; Lopaschuk Gary D; Moran Timothy H
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17358-63.
2007: Wallis Gareth A; Friedlander Anne L; Jacobs Kevin A; Horning Michael A; Fattor Jill A; Wolfel Eugene E; Lopaschuk Gary D; Brooks George A
Substantial working muscle glycerol turnover during two-legged cycle ergometry.
American journal of physiology. Endocrinology and metabolism 2007;293(4):E950-7.
2007: Putman Charles T; Martins Karen J B; Gallo Maria E; Lopaschuk Gary D; Pearcey Jean A; MacLean Ian M; Saranchuk Ryan J; Pette Dirk
Alpha-catalytic subunits of 5'AMP-activated protein kinase display fiber-specific expression and are upregulated by chronic low-frequency stimulation in rat muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1325-34.
2007: Onay-Besikci Arzu; Wagg Cory; Lopaschuk Timothy P; Keung Wendy; Lopaschuk Gary D
Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts.
Basic research in cardiology 2007;102(5):436-44.
2007: Lopaschuk Gary D; Folmes Clifford D L; Stanley William C
Cardiac energy metabolism in obesity.
Circulation research 2007;101(4):335-47.
2007: Lam Anna; Lopaschuk Gary D
Anti-anginal effects of partial fatty acid oxidation inhibitors.
Current opinion in pharmacology 2007;7(2):179-85.
2007: Noga Anna A; Soltys Carrie-Lynn M; Barr Amy J; Kovacic Suzanne; Lopaschuk Gary D; Dyck Jason R B
Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy.
American journal of physiology. Heart and circulatory physiology 2007;292(3):H1460-9.
2007: Bonnet Sébastien; Archer Stephen L; Allalunis-Turner Joan; Haromy Alois; Beaulieu Christian; Thompson Richard; Lee Christopher T; Lopaschuk Gary D; Puttagunta Lakshmi; Bonnet Sandra; Harry Gwyneth; Hashimoto Kyoko; Porter Christopher J; Andrade Miguel A; Thebaud Bernard; Michelakis Evangelos D
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Cancer cell 2007;11(1):37-51.
2007: Folmes Clifford D L; Lopaschuk Gary D
Role of malonyl-CoA in heart disease and the hypothalamic control of obesity.
Cardiovascular research 2007;73(2):278-87.
2007: Taha Maysa; Lopaschuk Gary D
Alterations in energy metabolism in cardiomyopathies.
Annals of medicine 2007;39(8):594-607.
2006: Lopaschuk Gary D; Stanley William C
Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(6):433-9.
2006: Dyck Jason R B; Hopkins Teresa A; Bonnet Sebastien; Michelakis Evangelos D; Young Martin E; Watanabe Miho; Kawase Yosuke; Jishage Kou-ichi; Lopaschuk Gary D
Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.
Circulation 2006;114(16):1721-8.
2006: Lopaschuk Gary D
Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.
Seminars in cardiothoracic and vascular anesthesia 2006;10(3):228-30.
2006: Lopaschuk Gary D
Cardiac energy metabolism alterations in angiotensin II induced hypertrophy.
Journal of molecular and cellular cardiology 2006;41(3):418-20.
2006: Cheng Jie-Fei; Huang Yujin; Penuliar Richard; Nishimoto Masahiro; Liu Larry; Arrhenius Thomas; Yang Guang; O'leary Eoin; Barbosa Miguel; Barr Rick; Dyck Jason R B; Lopaschuk Gary D; Nadzan Alex M
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
Journal of medicinal chemistry 2006;49(14):4055-8.
2006: Folmes Clifford D L; Clanachan Alexander S; Lopaschuk Gary D
Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia.
Circulation research 2006;99(1):61-8.
2006: Dyck Jason R B; Lopaschuk Gary D
AMPK alterations in cardiac physiology and pathology: enemy or ally?
The Journal of physiology 2006;574(Pt 1):95-112.
2006: Cheng Jie-Fei; Mak Chi Ching; Huang Yujin; Penuliar Richard; Nishimoto Masahiro; Zhang Lin; Chen Mi; Wallace David; Arrhenius Thomas; Chu Donald; Yang Guang; Barbosa Miguel; Barr Rick; Dyck Jason R B; Lopaschuk Gary D; Nadzan Alex M
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(13):3484-8.
2006: Collier Cheryl A; Bruce Clinton R; Smith Angela C; Lopaschuk Gary; Dyck David J
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E182-9.
2006: Fragasso Gabriele; Montano Chiara; Perseghin Gianluca; Palloshi Altin; Calori Giliola; Lattuada Guido; Oggionni Silvia; Bassanelli Giorgio; Locatelli Massimo; Lopaschuk Gary; Margonato Alberto
The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.
American heart journal 2006;151(6):1238.e1-8.
2006: Cheng Jie-Fei; Chen Mi; Wallace David; Tith Souvothy; Haramura Masayuki; Liu Bin; Mak Chi Ching; Arrhenius Thomas; Reily Sean; Brown Steven; Thorn Vicki; Harmon Charles; Barr Rick; Dyck Jason R B; Lopaschuk Gary D; Nadzan Alex M
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Journal of medicinal chemistry 2006;49(5):1517-25.
2006: Huang Wan; Dedousis Nikolas; Bandi Archana; Lopaschuk Gary D; O'Doherty Robert M
Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo.
Endocrinology 2006;147(3):1480-7.
2006: DeGrado Timothy R; Kitapci Mehmet T; Wang Shuyan; Ying Jun; Lopaschuk Gary D
Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(1):173-81.
2006: Sambandam Nandakumar; Morabito Dominique; Wagg Cory; Finck Brian N; Kelly Daniel P; Lopaschuk Gary D
Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H87-95.
2005: Stanley William C; Morgan Eric E; Huang Hazel; McElfresh Tracy A; Sterk Joseph P; Okere Isidore C; Chandler Margaret P; Cheng Jiefei; Dyck Jason R B; Lopaschuk Gary D
Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2304-9.
2005: King Kristen L; Okere Isidore C; Sharma Naveen; Dyck Jason R B; Reszko Aneta E; McElfresh Tracy A; Kerner Janos; Chandler Margaret P; Lopaschuk Gary D; Stanley William C
Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1033-7.
2005: Stanley William C; Recchia Fabio A; Lopaschuk Gary D
Myocardial substrate metabolism in the normal and failing heart.
Physiological reviews 2005;85(3):1093-129.
2005: Al-Hesayen Abdul; Azevedo Eduardo R; Floras John S; Hollingshead Shauna; Lopaschuk Gary D; Parker John D
Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2005;7(4):618-23.
2005: Folmes Clifford D L; Clanachan Alexander S; Lopaschuk Gary D
Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis.
Current atherosclerosis reports 2005;7(1):63-70.
2005: Sheth Sonal S; Castellani Lawrence W; Chari Soumya; Wagg Cory; Thipphavong Christopher K; Bodnar Jackie S; Tontonoz Peter; Attie Alan D; Lopaschuk Gary D; Lusis Aldons J
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition.
Journal of lipid research 2005;46(1):123-34.
2005: Altarejos Judith Y; Taniguchi Masayuki; Clanachan Alexander S; Lopaschuk Gary D
Myocardial ischemia differentially regulates LKB1 and an alternate 5'-AMP-activated protein kinase kinase.
The Journal of biological chemistry 2005;280(1):183-90.
2004: Dai Tong; Abou-Rjaily George A; Al-Share' Qusai Y; Yang Yan; Fernström Mats A; Deangelis Anthony M; Lee Abraham D; Sweetman Lawrence; Amato Antonino; Pasquali Marzia; Lopaschuk Gary D; Erickson Sandra K; Najjar Sonia M
Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice.
The Journal of biological chemistry 2004;279(43):45155-61.
2004: Onay-Besikci Arzu; Altarejos Judith Y; Lopaschuk Gary D
gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts.
The Journal of biological chemistry 2004;279(43):44320-6.
2004: Reszko Aneta E; Kasumov Takhar; David France; Thomas Katherine R; Jobbins Kathryn A; Cheng Jie-Fei; Lopaschuk Gary D; Dyck Jason R B; Diaz Mireya; Des Rosiers Christine; Stanley William C; Brunengraber Henri
Regulation of malonyl-CoA concentration and turnover in the normal heart.
The Journal of biological chemistry 2004;279(33):34298-301.
2004: Lopaschuk Gary D
Glutamate transport in the heart: lessons learned from the brain.
Journal of molecular and cellular cardiology 2004;37(1):5-6.
2004: Sambandam Nandakumar; Steinmetz Michael; Chu Angel; Altarejos Judith Y; Dyck Jason R B; Lopaschuk Gary D
Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique.
European journal of biochemistry / FEBS 2004;271(13):2831-40.
2004: Leon Hernando; Atkinson Laura L; Sawicka Jolanta; Strynadka Ken; Lopaschuk Gary D; Schulz Richard
Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts.
Canadian journal of physiology and pharmacology 2004;82(6):409-16.
2004: Dyck Jason R B; Cheng Jie-Fei; Stanley William C; Barr Rick; Chandler Margaret P; Brown Steven; Wallace David; Arrhenius Thomas; Harmon Charles; Yang Guang; Nadzan Alex M; Lopaschuk Gary D
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.
Circulation research 2004;94(9):e78-84.
2004: Zhou Demin; Yuen Phoebe; Chu Donald; Thon Vicki; McConnell Steve; Brown Steven; Tsang Andria; Pena Michael; Russell Anna; Cheng Jie-Fei; Nadzan Alex M; Barbosa Miguel S; Dyck Jason R B; Lopaschuk Gary D; Yang Guang
Expression, purification, and characterization of human malonyl-CoA decarboxylase.
Protein expression and purification 2004;34(2):261-9.
2004: Lopaschuk Gary D
Targets for modulation of fatty acid oxidation in the heart.
Current opinion in investigational drugs (London, England : 2000) 2004;5(3):290-4.
2004: Kuang Michael; Febbraio Maria; Wagg Cory; Lopaschuk Gary D; Dyck Jason R B
Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia.
Circulation 2004;109(12):1550-7.
2004: Fukao Toshiyuki; Lopaschuk Gary D; Mitchell Grant A
Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.
Prostaglandins, leukotrienes, and essential fatty acids 2004;70(3):243-51.
2004: Armstrong Paul W; Ezekowitz Christina; Michelakis Evangelos; Anderson Todd; Archer Stephen; Ghali William; Hayward Robert; Jensen Louise; Lopaschuk Gary; Sheldon Robert
Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH).
Clinical and investigative medicine. Médecine clinique et experimentale 2004;27(1):33-41.
2003: Bamford Jeremy A; Lopaschuk Gary D; MacLean Ian M; Reinhart Marcia L; Dixon Walter T; Putman Charles T
Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles.
Canadian journal of physiology and pharmacology 2003;81(11):1072-82.
2003: Fragasso G; Piatti Md P M; Monti L; Palloshi A; Setola E; Puccetti P; Calori G; Lopaschuk G D; Margonato A
Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.
American heart journal 2003;146(5):E18.
2003: Stanley William C; Meadows Steven R; Kivilo Krista M; Roth Bridgette A; Lopaschuk Gary D
beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content.
American journal of physiology. Heart and circulatory physiology 2003;285(4):H1626-31.
2003: Lopaschuk Gary D; Barr Rick; Thomas Panakkezhum D; Dyck Jason R B
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
Circulation research 2003;93(3):e33-7.
2003: Hopkins Teresa A; Sugden Mary C; Holness Mark J; Kozak Ray; Dyck Jason R B; Lopaschuk Gary D
Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H270-6.
2003: Sambandam Nandakumar; Lopaschuk Gary D
AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart.
Progress in lipid research 2003;42(3):238-56.
2003: Atkinson Laura L; Kozak Ray; Kelly Sandra E; Onay Besikci Arzu; Russell James C; Lopaschuk Gary D
Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats.
American journal of physiology. Endocrinology and metabolism 2003;284(5):E923-30.
2003: Hopkins T A; Dyck J R B; Lopaschuk G D
AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart.
Biochemical Society transactions 2003;31(Pt 1):207-12.
2003: Onay-Besikci Arzu; Campbell Fiona M; Hopkins Teresa A; Dyck Jason R B; Lopaschuk Gary D;
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H283-9.
2002: Dyck Jason R B; Lopaschuk Gary D
Malonyl CoA control of fatty acid oxidation in the ischemic heart.
Journal of molecular and cellular cardiology 2002;34(9):1099-109.
2002: Lopaschuk Gary D; Opie Lionel H
Introduction to JMCC symposium on myocardial energy metabolism in health and disease.
Journal of molecular and cellular cardiology 2002;34(9):1075-6.
2002: Atkinson Laura L; Fischer Melanie A; Lopaschuk Gary D
Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis.
The Journal of biological chemistry 2002;277(33):29424-30.
2002: Osorio Juan Carlos; Stanley William C; Linke Axel; Castellari Michele; Diep Quy N; Panchal Ashish R; Hintze Thomas H; Lopaschuk Gary D; Recchia Fabio A
Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure.
Circulation 2002;106(5):606-12.
2002: Atkinson Laura L; Kelly Sandra E; Russell James C; Bar-Tana Jacob; Lopaschuk Gary D
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.
Diabetes 2002;51(5):1548-55.
2002: Leong Hon Sing; Grist Mark; Parsons Hannah; Wambolt Richard B; Lopaschuk Gary D; Brownsey Roger; Allard Michael F
Accelerated rates of glycolysis in the hypertrophied heart: are they a methodological artifact?
American journal of physiology. Endocrinology and metabolism 2002;282(5):E1039-45.
2002: Sambandam Nandakumar; Lopaschuk Gary D; Brownsey Roger W; Allard Michael F
Energy metabolism in the hypertrophied heart.
Heart failure reviews 2002;7(2):161-73.
2002: Lopaschuk Gary D
Metabolic abnormalities in the diabetic heart.
Heart failure reviews 2002;7(2):149-59.
2002: Xu Yi; Kumar Dinender; Dyck Jason R B; Ford William R; Clanachan Alexander S; Lopaschuk Gary D; Jugdutt Bodh I
AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1206-15.
2002: Liu Que; Docherty John C; Rendell John C T; Clanachan Alexander S; Lopaschuk Gary D
High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation.
Journal of the American College of Cardiology 2002;39(4):718-25.
2002: Campbell Fiona M; Kozak Ray; Wagner Alese; Altarejos Judith Y; Dyck Jason R B; Belke Darrell D; Severson David L; Kelly Daniel P; Lopaschuk Gary D
A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase.
The Journal of biological chemistry 2002;277(6):4098-103.
2002: Michelakis Evangelos D; McMurtry M Sean; Wu Xi-Chen; Dyck Jason R B; Moudgil Rohit; Hopkins Teresa A; Lopaschuk Gary D; Puttagunta Lakshmi; Waite Ross; Archer Stephen L
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Circulation 2002;105(2):244-50.
2002: Lopaschuk Gary D; Rebeyka Ivan M; Allard Michael F
Metabolic modulation: a means to mend a broken heart.
Circulation 2002;105(2):140-2.
2002: Finck Brian N; Lehman John J; Leone Teresa C; Welch Michael J; Bennett Michael J; Kovacs Attila; Han Xianlin; Gross Richard W; Kozak Ray; Lopaschuk Gary D; Kelly Daniel P
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
The Journal of clinical investigation 2002;109(1):121-30.
2002: Recchia Fabio A; Osorio Juan Carlos; Chandler Margaret P; Xu Xiaobin; Panchal Ashish R; Lopaschuk Gary D; Hintze Thomas H; Stanley William C
Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs.
American journal of physiology. Endocrinology and metabolism 2002;282(1):E197-206.
2001: Longnus S L; Wambolt R B; Barr R L; Lopaschuk G D; Allard M F
Regulation of myocardial fatty acid oxidation by substrate supply.
American journal of physiology. Heart and circulatory physiology 2001;281(4):H1561-7.
2001: Taniguchi M; Wilson C; Hunter C A; Pehowich D J; Clanachan A S; Lopaschuk G D
Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1762-9.
2001: Lopaschuk G D
Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?
Coronary artery disease 2001;12 Suppl 1():S8-11.
2001: Lopaschuk G D
Malonyl CoA control of fatty acid oxidation in the diabetic rat heart.
Advances in experimental medicine and biology 2001;498():155-65.
2000: Wambolt R B; Lopaschuk G D; Brownsey R W; Allard M F
Dichloroacetate improves postischemic function of hypertrophied rat hearts.
Journal of the American College of Cardiology 2000;36(4):1378-85.
2000: Ford W R; Jugdutt B I; Lopaschuk G D; Schulz R; Clanachan A S
Influence of beta-adrenoceptor tone on the cardioprotective efficacy of adenosine A(1) receptor activation in isolated working rat hearts.
British journal of pharmacology 2000;131(3):537-45.
2000: Dyck J R; Berthiaume L G; Thomas P D; Kantor P F; Barr A J; Barr R; Singh D; Hopkins T A; Voilley N; Prentki M; Lopaschuk G D
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism.
The Biochemical journal 2000;350 Pt 2():599-608.
2000: Sakamoto J; Barr R L; Kavanagh K M; Lopaschuk G D
Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart.
American journal of physiology. Heart and circulatory physiology 2000;278(4):H1196-204.
2000: Barr R L; Lopaschuk G D
Methodology for measuring in vitro/ex vivo cardiac energy metabolism.
Journal of pharmacological and toxicological methods 2000;43(2):141-52.
2000: Kantor P F; Lucien A; Kozak R; Lopaschuk G D
The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Circulation research 2000;86(5):580-8.
2000: Lopaschuk G
Regulation of carbohydrate metabolism in ischemia and reperfusion.
American heart journal 2000;139(2 Pt 3):S115-9.
1999: Fraser H; Lopaschuk G D; Clanachan A S
Alteration of glycogen and glucose metabolism in ischaemic and post-ischaemic working rat hearts by adenosine A1 receptor stimulation.
British journal of pharmacology 1999;128(1):197-205.
1999: Kantor P F; Dyck J R; Lopaschuk G D
Fatty acid oxidation in the reperfused ischemic heart.
The American journal of the medical sciences 1999;318(1):3-14.
1999: Kantor P F; Robertson M A; Coe J Y; Lopaschuk G D
Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism.
Journal of the American College of Cardiology 1999;33(6):1724-34.
1999: Dyck J R; Kudo N; Barr A J; Davies S P; Hardie D G; Lopaschuk G D
Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase.
European journal of biochemistry / FEBS 1999;262(1):184-90.
1999: Voilley N; Roduit R; Vicaretti R; Bonny C; Waeber G; Dyck J R; Lopaschuk G D; Prentki M
Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase.
The Biochemical journal 1999;340 ( Pt 1)():213-7.
1999: Wambolt R B; Henning S L; English D R; Dyachkova Y; Lopaschuk G D; Allard M F
Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia.
Journal of molecular and cellular cardiology 1999;31(3):493-502.
1998: Lopaschuk G D
[Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism]
Presse médicale (Paris, France : 1983) 1998;27(39):2100-4.
1998: Dyck J R; Barr A J; Barr R L; Kolattukudy P E; Lopaschuk G D
Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation.
The American journal of physiology 1998;275(6 Pt 2):H2122-9.
1998: Makinde A O; Kantor P F; Lopaschuk G D
Maturation of fatty acid and carbohydrate metabolism in the newborn heart.
Molecular and cellular biochemistry 1998;188(1-2):49-56.
1998: Fraser H; Lopaschuk G D; Clanachan A S
Assessment of glycogen turnover in aerobic, ischemic, and reperfused working rat hearts.
The American journal of physiology 1998;275(5 Pt 2):H1533-41.
1998: Saiki Y; Lopaschuk G D; Dodge K; Yamaya K; Morgan C; Rebeyka I M
Pyruvate augments mechanical function via activation of the pyruvate dehydrogenase complex in reperfused ischemic immature rabbit hearts.
The Journal of surgical research 1998;79(2):164-9.
1998: Lopaschuk G D
Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism.
The American journal of cardiology 1998;82(5A):14K-17K.
1998: Liu Q; Clanachan A S; Lopaschuk G D
Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts.
The American journal of physiology 1998;275(3 Pt 1):E392-9.
1998: Ford W R; Lopaschuk G D; Schulz R; Clanachan A S
K(ATP)-channel activation: effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation.
British journal of pharmacology 1998;124(4):639-46.
1998: Ford W R; Clanachan A S; Lopaschuk G D; Schulz R; Jugdutt B I
Intrinsic ANG II type 1 receptor stimulation contributes to recovery of postischemic mechanical function.
The American journal of physiology 1998;274(5 Pt 2):H1524-31.
1998: Dyck J R; Lopaschuk G D
Glucose metabolism, H+ production and Na+/H+-exchanger mRNA levels in ischemic hearts from diabetic rats.
Molecular and cellular biochemistry 1998;180(1-2):85-93.
1998: Belke D D; Wang L C; Lopaschuk G D
Acetyl-CoA carboxylase control of fatty acid oxidation in hearts from hibernating Richardson's ground squirrels.
Biochimica et biophysica acta 1998;1391(1):25-36.
1997: Gamble J; Lopaschuk G D
Insulin inhibition of 5' adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation.
Metabolism: clinical and experimental 1997;46(11):1270-4.
1997: Schönekess B O; Allard M F; Henning S L; Wambolt R B; Lopaschuk G D
Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart.
Circulation research 1997;81(4):540-9.
1997: Barr R L; Lopaschuk G D
Direct measurement of energy metabolism in the isolated working rat heart.
Journal of pharmacological and toxicological methods 1997;38(1):11-7.
1997: Lopaschuk G D
Alterations in fatty acid oxidation during reperfusion of the heart after myocardial ischemia.
The American journal of cardiology 1997;80(3A):11A-16A.
1997: Lopaschuk G D
Advantages and limitations of experimental techniques used to measure cardiac energy metabolism.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1997;4(4):316-28.
1997: Lopaschuk G D; Barr R L
Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart.
Molecular and cellular biochemistry 1997;172(1-2):137-47.
1997: Allard M F; Henning S L; Wambolt R B; Granleese S R; English D R; Lopaschuk G D
Glycogen metabolism in the aerobic hypertrophied rat heart.
Circulation 1997;96(2):676-82.
1997: Stanley W C; Lopaschuk G D; McCormack J G
Regulation of energy substrate metabolism in the diabetic heart.
Cardiovascular research 1997;34(1):25-33.
1997: Makinde A O; Gamble J; Lopaschuk G D
Upregulation of 5'-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit.
Circulation research 1997;80(4):482-9.
1997: Belke D D; Wang L C; Lopaschuk G D
Effects of hypothermia on energy metabolism in rat and Richardson's ground squirrel hearts.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(4):1210-8.
1997: Schulz R; Dodge K L; Lopaschuk G D; Clanachan A S
Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency.
The American journal of physiology 1997;272(3 Pt 2):H1212-9.
1996: Finegan B A; Gandhi M; Lopaschuk G D; Clanachan A S
Antecedent ischemia reverses effects of adenosine on glycolysis and mechanical function of working hearts.
The American journal of physiology 1996;271(5 Pt 2):H2116-25.
1996: Liu B; Clanachan A S; Schulz R; Lopaschuk G D
Cardiac efficiency is improved after ischemia by altering both the source and fate of protons.
Circulation research 1996;79(5):940-8.
1996: Schönekess B O; Allard M F; Lopaschuk G D
Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts.
The American journal of physiology 1996;271(2 Pt 2):H798-805.
1996: Itoi T; Lopaschuk G D
Calcium improves mechanical function and carbohydrate metabolism following ischemia in isolated Bi-ventricular working hearts from immature rabbits.
Journal of molecular and cellular cardiology 1996;28(7):1501-14.
1996: Olley P M; Kasserra J; Kozak R; Lopaschuk G D
Synergism between prostaglandin E2 and isoproterenol in stimulating glucose oxidation in the heart.
Canadian journal of physiology and pharmacology 1996;74(5):590-7.
1996: Finegan B A; Lopaschuk G D; Gandhi M; Clanachan A S
Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A1 receptor stimulation during reperfusion following ischaemia.
British journal of pharmacology 1996;118(2):355-63.
1996: Kudo N; Gillespie J G; Kung L; Witters L A; Schulz R; Clanachan A S; Lopaschuk G D
Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia.
Biochimica et biophysica acta 1996;1301(1-2):67-75.
1996: Henning S L; Wambolt R B; Schönekess B O; Lopaschuk G D; Allard M F
Contribution of glycogen to aerobic myocardial glucose utilization.
Circulation 1996;93(8):1549-55.
1996: Liu B; el Alaoui-Talibi Z; Clanachan A S; Schulz R; Lopaschuk G D
Uncoupling of contractile function from mitochondrial TCA cycle activity and MVO2 during reperfusion of ischemic hearts.
The American journal of physiology 1996;270(1 Pt 2):H72-80.
1996: McCormack J G; Barr R L; Wolff A A; Lopaschuk G D
Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts.
Circulation 1996;93(1):135-42.
1996: Allard M F; Lopaschuk G D
Ischemia and reperfusion injury in the hypertrophied heart.
EXS 1996;76():423-41.
1995: Schönekess B O; Brindley P G; Lopaschuk G D
Calcium regulation of glycolysis, glucose oxidation, and fatty acid oxidation in the aerobic and ischemic heart.
Canadian journal of physiology and pharmacology 1995;73(11):1632-40.
1995: Schönekess B O; Allard M F; Lopaschuk G D
Propionyl L-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency.
European journal of pharmacology 1995;286(2):155-66.
1995: Finegan B A; Lopaschuk G D; Gandhi M; Clanachan A S
Ischemic preconditioning inhibits glycolysis and proton production in isolated working rat hearts.
The American journal of physiology 1995;269(5 Pt 2):H1767-75.
1995: Schönekess B O; Allard M F; Lopaschuk G D
Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation.
Circulation research 1995;77(4):726-34.
1995: Kudo N; Barr A J; Barr R L; Desai S; Lopaschuk G D
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase.
The Journal of biological chemistry 1995;270(29):17513-20.
1995: Broderick T L; Quinney H A; Lopaschuk G D
L-carnitine increases glucose metabolism and mechanical function following ischaemia in diabetic rat heart.
Cardiovascular research 1995;29(3):373-8.
1995: Schulz R; Panas D L; Catena R; Moncada S; Olley P M; Lopaschuk G D
The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha.
British journal of pharmacology 1995;114(1):27-34.
1994: Collins-Nakai R L; Noseworthy D; Lopaschuk G D
Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism.
The American journal of physiology 1994;267(5 Pt 2):H1862-71.
1994: Montague T; DeAlmeida J; Lopaschuk G; Witkowski F; Walker D; Ackman M; Humen D; Dzavik V; Teo K
Enhanced glucose oxidation in exercise-induced myocardial ischemia.
The Canadian journal of cardiology 1994;10(9):913-9.
1994: Lopaschuk G D; Witters L A; Itoi T; Barr R; Barr A
Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart.
The Journal of biological chemistry 1994;269(41):25871-8.
1994: Saddik M; Lopaschuk G D
Triacylglycerol turnover in isolated working hearts of acutely diabetic rats.
Canadian journal of physiology and pharmacology 1994;72(10):1110-9.
1994: Lopaschuk G D; Gamble J
The 1993 Merck Frosst Award. Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart.
Canadian journal of physiology and pharmacology 1994;72(10):1101-9.
1994: Allard M F; Schönekess B O; Henning S L; English D R; Lopaschuk G D
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.
The American journal of physiology 1994;267(2 Pt 2):H742-50.
1994: Lopaschuk G D; Belke D D; Gamble J; Itoi T; Schönekess B O
Regulation of fatty acid oxidation in the mammalian heart in health and disease.
Biochimica et biophysica acta 1994;1213(3):263-76.
1994: Lopaschuk G D; Collins-Nakai R; Olley P M; Montague T J; McNeil G; Gayle M; Penkoske P; Finegan B A
Plasma fatty acid levels in infants and adults after myocardial ischemia.
American heart journal 1994;128(1):61-7.
1994: Gamble J; Lopaschuk G D
Glycolysis and glucose oxidation during reperfusion of ischemic hearts from diabetic rats.
Biochimica et biophysica acta 1994;1225(2):191-9.
1993: Lopaschuk G D; Lakey J R; Barr R; Wambolt R; Thomson A B; Clandinin M T; Rajotte R V
Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts.
Canadian journal of physiology and pharmacology 1993;71(12):896-903.
1993: Itoi T; Lopaschuk G D
The contribution of glycolysis, glucose oxidation, lactate oxidation, and fatty acid oxidation to ATP production in isolated biventricular working hearts from 2-week-old rabbits.
Pediatric research 1993;34(6):735-41.
1993: Saddik M; Gamble J; Witters L A; Lopaschuk G D
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.
The Journal of biological chemistry 1993;268(34):25836-45.
1993: Itoi T; Huang L; Lopaschuk G D
Glucose use in neonatal rabbit hearts reperfused after global ischemia.
The American journal of physiology 1993;265(2 Pt 2):H427-33.
1993: Schulz R; Strynadka K D; Panas D L; Olley P M; Lopaschuk G D
Analysis of myocardial plasmalogen and diacyl phospholipids and their arachidonic acid content using high-performance liquid chromatography.
Analytical biochemistry 1993;213(1):140-6.
1993: Broderick T L; Quinney H A; Barker C C; Lopaschuk G D
Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.
Circulation 1993;87(3):972-81.
1993: Finegan B A; Lopaschuk G D; Coulson C S; Clanachan A S
Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts.
Circulation 1993;87(3):900-8.
1993: Lopaschuk G D; Wambolt R B; Barr R L
An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.
The Journal of pharmacology and experimental therapeutics 1993;264(1):135-44.
1993: Mao G D; Thomas P D; Lopaschuk G D; Poznansky M J
Superoxide dismutase (SOD)-catalase conjugates. Role of hydrogen peroxide and the Fenton reaction in SOD toxicity.
The Journal of biological chemistry 1993;268(1):416-20.
1992: Lopaschuk G D; Saddik M; Barr R; Huang L; Barker C C; Muzyka R A
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats.
The American journal of physiology 1992;263(6 Pt 1):E1046-53.
1992: Wong R; Lopaschuk G; Zhu G; Walker D; Catellier D; Burton D; Teo K; Collins-Nakai R; Montague T
Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.
Chest 1992;102(6):1716-22.
1992: Lopaschuk G D; Collins-Nakai R L; Itoi T
Developmental changes in energy substrate use by the heart.
Cardiovascular research 1992;26(12):1172-80.
1992: Lopaschuk G D; Spafford M A
Differences in myocardial ischemic tolerance between 1- and 7-day-old rabbits.
Canadian journal of physiology and pharmacology 1992;70(10):1315-23.
1992: Lopaschuk G D; Saddik M
The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia.
Molecular and cellular biochemistry 1992;116(1-2):111-6.
1992: Wong R; Lopaschuk G; Teo K; Walker D; Catellier D; Zhu G; Burton D; Collins-Nakai R; Montague T
In vivo skeletal muscle metabolism during dynamic exercise and recovery: assessment by nuclear magnetic resonance spectroscopy.
The Canadian journal of cardiology 1992;8(8):819-24.
1992: Dyck J R; Lopaschuk G D; Fliegel L
Identification of a small Na+/H+ exchanger-like message in the rabbit myocardium.
FEBS letters 1992;310(3):255-9.
1992: Davies N J; Lovlin R E; Lopaschuk G D
Effect of exogenous fatty acids on reperfusion arrhythmias in isolated working perfused hearts.
The American journal of physiology 1992;262(6 Pt 2):H1796-801.
1992: Davies N J; Schulz R; Olley P M; Strynadka K D; Panas D L; Lopaschuk G D
Lysoplasmenylethanolamine accumulation in ischemic/reperfused isolated fatty acid-perfused hearts.
Circulation research 1992;70(6):1161-8.
1992: Finegan B A; Clanachan A S; Coulson C S; Lopaschuk G D
Adenosine modification of energy substrate use in isolated hearts perfused with fatty acids.
The American journal of physiology 1992;262(5 Pt 2):H1501-7.
1992: Lerner R W; Lopaschuk G D; Catena R C; Olley P M
[3H]iloprost and prostaglandin E2 compete for the same receptor site on cardiac sarcolemmal membranes.
Biochimica et biophysica acta 1992;1105(2):189-92.
1992: Lopaschuk G D; Barr R; Wambolt R
Effects of diltiazem on glycolysis and oxidative metabolism in the ischemic and ischemic/reperfused heart.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1220-8.
1992: Broderick T L; Barr R L; Quinney H A; Lopaschuk G D
Acute insulin withdrawal from diabetic BB rats decreases myocardial glycolysis during low-flow ischemia.
Metabolism: clinical and experimental 1992;41(3):332-8.
1992: Saddik M; Lopaschuk G D
Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia.
The Journal of biological chemistry 1992;267(6):3825-31.
1992: Broderick T L; Quinney H A; Lopaschuk G D
Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart.
The Journal of biological chemistry 1992;267(6):3758-63.
1992: Lerner R W; Lopaschuk G D; Olley P M
Prostaglandin E2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein.
Canadian journal of physiology and pharmacology 1992;70(1):77-84.
1991: Lopaschuk G D; Spafford M A; Marsh D R
Glycolysis is predominant source of myocardial ATP production immediately after birth.
The American journal of physiology 1991;261(6 Pt 2):H1698-705.
1991: Saddik M; Lopaschuk G D
The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A.
Biochimica et biophysica acta 1991;1086(2):217-24.
1991: Nicholl T A; Lopaschuk G D; McNeill J H
Effects of free fatty acids and dichloroacetate on isolated working diabetic rat heart.
The American journal of physiology 1991;261(4 Pt 2):H1053-9.
1991: Lopaschuk G D; Russell J C
Myocardial function and energy substrate metabolism in the insulin-resistant JCR:LA corpulent rat.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(4):1302-8.
1991: Saddik M; Lopaschuk G D
Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts.
The Journal of biological chemistry 1991;266(13):8162-70.
1991: Davies N J; McVeigh J J; Lopaschuk G D
Effects of TA-3090, a new calcium channel blocker, on myocardial substrate utilization in ischemic and nonischemic isolated working fatty acid-perfused rat hearts.
Circulation research 1991;68(3):807-17.
1990: Lerner R W; Lopaschuk G D; Olley P M
High-affinity prostaglandin E receptors attenuate adenylyl cyclase activity in isolated bovine myometrial membrane.
Canadian journal of physiology and pharmacology 1990;68(12):1574-80.
1990: Wong R; Davies N; Marshall D; Allen P; Zhu G; Lopaschuk G; Montague T
Metabolism of normal skeletal muscle during dynamic exercise to clinical fatigue: in vivo assessment by nuclear magnetic resonance spectroscopy.
The Canadian journal of cardiology 1990;6(9):391-5.
1990: McVeigh J J; Lopaschuk G D
Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts.
The American journal of physiology 1990;259(4 Pt 2):H1079-85.
1990: Montague T J; Lopaschuk G D; Davies N J
Viral heart disease.
Chest 1990;98(1):190-9.
1990: Lopaschuk G D; Spafford M A
Energy substrate utilization by isolated working hearts from newborn rabbits.
The American journal of physiology 1990;258(5 Pt 2):H1274-80.
1990: Lopaschuk G D; Spafford M A
Acute insulin withdrawal contributes to ischemic heart failure in spontaneously diabetic BB Wistar rats.
Canadian journal of physiology and pharmacology 1990;68(3):462-6.
1990: Lopaschuk G D; Spafford M A; Davies N J; Wall S R
Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia.
Circulation research 1990;66(2):546-53.
1989: Wall S R; Lopaschuk G D
Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats.
Biochimica et biophysica acta 1989;1006(1):97-103.
1989: Lopaschuk G D
Alterations in myocardial fatty acid metabolism contribute to ischemic injury in the diabetic.
The Canadian journal of cardiology 1989;5(6):315-20.
1989: Lopaschuk G D; Michalak M; Wandler E L; Lerner R W; Piscione T D; Coceani F; Olley P M
Prostaglandin E receptors in cardiac sarcolemma. Identification and coupling to adenylate cyclase.
Circulation research 1989;65(3):538-45.
1989: Lopaschuk G D; Spafford M
Response of isolated working hearts to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow in acutely and chronically diabetic rats.
Circulation research 1989;65(2):378-87.
1989: Lopaschuk G D; McNeil G F; McVeigh J J
Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir.
Molecular and cellular biochemistry 1989;88(1-2):175-9.
1988: Lopaschuk G D; Wall S R; Olley P M; Davies N J
Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine.
Circulation research 1988;63(6):1036-43.
1987: Lopaschuk G D; Tsang H
Metabolism of palmitate in isolated working hearts from spontaneously diabetic "BB" Wistar rats.
Circulation research 1987;61(6):853-8.

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