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Carlos López-Otín

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
López-Otín Carlos; Palavalli Lavanya H; Samuels Yardena
Protective roles of matrix metalloproteinases: from mouse models to human cancer.
Laxton Ross C; Hu Yanhua; Duchene Johan; Zhang Feng; Zhang Zhongyi; Leung Kit-Yi; Xiao Qingzhong; Scotland Ramona S; Hodgkinson Conrad P; Smith Katherine; Willeit Johann; López-Otín Carlos; Simpson Iain A; Kiechl Stefan; Ahluwalia Amrita; Xu Qingbo; Ye Shu
A role of matrix metalloproteinase-8 in atherosclerosis.
Ramsay Andrew J; Quesada Victor; Sanchez Mayka; Garabaya Cecilia; Sardà María P; Baiget Montserrat; Remacha Angel; Velasco Gloria; López-Otín Carlos
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.

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All Publications

2009: López-Otín Carlos; Palavalli Lavanya H; Samuels Yardena
Protective roles of matrix metalloproteinases: from mouse models to human cancer.
Cell cycle (Georgetown, Tex.) 2009;8(22):3657-62.
2009: Laxton Ross C; Hu Yanhua; Duchene Johan; Zhang Feng; Zhang Zhongyi; Leung Kit-Yi; Xiao Qingzhong; Scotland Ramona S; Hodgkinson Conrad P; Smith Katherine; Willeit Johann; López-Otín Carlos; Simpson Iain A; Kiechl Stefan; Ahluwalia Amrita; Xu Qingbo; Ye Shu
A role of matrix metalloproteinase-8 in atherosclerosis.
Circulation research 2009;105(9):921-9.
2009: Ramsay Andrew J; Quesada Victor; Sanchez Mayka; Garabaya Cecilia; Sardà María P; Baiget Montserrat; Remacha Angel; Velasco Gloria; López-Otín Carlos
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.
Human molecular genetics 2009;18(19):3673-83.
2009: Folgueras Alicia R; Valdés-Sánchez Teresa; Llano Elena; Menéndez Luis; Baamonde Ana; Denlinger Bristol L; Belmonte Carlos; Juárez Lucía; Lastra Ana; García-Suárez Olivia; Astudillo Aurora; Kirstein Martina; Pendás Alberto M; Fariñas Isabel; López-Otín Carlos
Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16451-6.
2009: Alvarez-Díaz Silvia; Valle Noelia; García José Miguel; Peña Cristina; Freije José M P; Quesada Víctor; Astudillo Aurora; Bonilla Félix; López-Otín Carlos; Muñoz Alberto
Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.
The Journal of clinical investigation 2009;119(8):2343-58.
2009: Moncada-Pazos Angela; Obaya Alvaro J; Fraga Mario F; Viloria Cristina G; Capellá Gabriel; Gausachs Mireia; Esteller Manel; López-Otín Carlos; Cal Santiago
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
Journal of cell science 2009;122(Pt 16):2906-13.
2009: Viloria Cristina G; Obaya Alvaro J; Moncada-Pazos Angela; Llamazares María; Astudillo Aurora; Capellá Gabriel; Cal Santiago; López-Otín Carlos
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.
Cancer research 2009;69(11):4926-34.
2009: Ramsay Andrew J; Hooper John D; Folgueras Alicia R; Velasco Gloria; López-Otín Carlos
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis.
Haematologica 2009;94(6):840-9.
2009: Osorio Fernando G; Obaya Alvaro J; López-Otín Carlos; Freije José M P
Accelerated ageing: from mechanism to therapy through animal models.
Transgenic research 2009;18(1):7-15.
2009: Ordóñez Gonzalo R; Puente Xose S; Quesada Víctor; López-Otín Carlos
Proteolytic systems: constructing degradomes.
Methods in molecular biology (Clifton, N.J.) 2009;539():33-47.
2008: López-Otín Carlos; Bond Judith S
Proteases: multifunctional enzymes in life and disease.
The Journal of biological chemistry 2008;283(45):30433-7.
2008: Folgueras Alicia R; de Lara Fernando Martín; Pendás Alberto M; Garabaya Cecilia; Rodríguez Francisco; Astudillo Aurora; Bernal Teresa; Cabanillas Rubén; López-Otín Carlos; Velasco Gloria
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.
Blood 2008;112(6):2539-45.
2008: Lizarbe Tania R; García-Rama Concepción; Tarín Carlos; Saura Marta; Calvo Enrique; López Juan Antonio; López-Otín Carlos; Folgueras Alicia R; Lamas Santiago; Zaragoza Carlos
Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3207-15.
2008: Mariño Guillermo; López-Otín Carlos
Autophagy and aging: new lessons from progeroid mice.
Autophagy 2008;4(6):807-9.
2008: Varela Ignacio; Pereira Sandrine; Ugalde Alejandro P; Navarro Claire L; Suárez María F; Cau Pierre; Cadiñanos Juan; Osorio Fernando G; Foray Nicolas; Cobo Juan; de Carlos Félix; Lévy Nicolas; Freije José M P; López-Otín Carlos
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.
Nature medicine 2008;14(7):767-72.
2008: Mariño Guillermo; Ugalde Alejandro P; Salvador-Montoliu Natalia; Varela Ignacio; Quirós Pedro M; Cadiñanos Juan; van der Pluijm Ingrid; Freije José M P; López-Otín Carlos
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
Human molecular genetics 2008;17(14):2196-211.
2008: Gutiérrez-Fernández Ana; Fueyo Antonio; Folgueras Alicia R; Garabaya Cecilia; Pennington Caroline J; Pilgrim Simon; Edwards Dylan R; Holliday Deborah L; Jones J Louise; Span Paul N; Sweep Fred C G J; Puente Xose S; López-Otín Carlos
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Cancer research 2008;68(8):2755-63.
2008: Espada Jesús; Varela Ignacio; Flores Ignacio; Ugalde Alejandro P; Cadiñanos Juan; Pendás Alberto M; Stewart Colin L; Tryggvason Karl; Blasco María A; Freije José M P; López-Otín Carlos
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.
The Journal of cell biology 2008;181(1):27-35.
2008: Folgueras Alicia R; Fueyo Antonio; García-Suárez Olivia; Cox Jennifer; Astudillo Aurora; Tortorella Paolo; Campestre Cristina; Gutiérrez-Fernández Ana; Fanjul-Fernández Miriam; Pennington Caroline J; Edwards Dylan R; Overall Christopher M; López-Otín Carlos
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
The Journal of biological chemistry 2008;283(14):9465-74.
2008: Ordoñez Gonzalo R; Hillier Ladeana W; Warren Wesley C; Grützner Frank; López-Otín Carlos; Puente Xose S
Loss of genes implicated in gastric function during platypus evolution.
Genome biology 2008;9(5):R81.
2007: Llamazares María; Obaya Alvaro J; Moncada-Pazos Angela; Heljasvaara Ritva; Espada Jesús; López-Otín Carlos; Cal Santiago
The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway.
Journal of cell science 2007;120(Pt 20):3544-52.
2007: López-Otín Carlos; Matrisian Lynn M
Emerging roles of proteases in tumour suppression.
Nature reviews. Cancer 2007;7(10):800-8.
2007: Gutiérrez-Fernández Ana; Inada Masaki; Balbín Milagros; Fueyo Antonio; Pitiot Ana S; Astudillo Aurora; Hirose Kenji; Hirata Michiko; Shapiro Steven D; Noël Agnès; Werb Zena; Krane Stephen M; López-Otín Carlos; Puente Xose S
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2580-91.
2007: Mariño Guillermo; Salvador-Montoliu Natalia; Fueyo Antonio; Knecht Erwin; Mizushima Noboru; López-Otín Carlos
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3.
The Journal of biological chemistry 2007;282(25):18573-83.
2007: Ramírez C L; Cadiñanos J; Varela I; Freije J M P; López-Otín C
Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions.
Cellular and molecular life sciences : CMLS 2007;64(2):155-70.
2007: Tester Angus M; Cox Jennifer H; Connor Andrea R; Starr Amanda E; Dean Richard A; Puente Xose S; López-Otín Carlos; Overall Christopher M
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.
PloS one 2007;2(3):e312.
2006: González L; Freije J M P; Cal S; López-Otín C; Serrano M; Palmero I
A functional link between the tumour suppressors ARF and p33ING1.
Oncogene 2006;25(37):5173-9.
2006: Jost Maud; Folgueras Alicia R; Frérart Françoise; Pendas Alberto M; Blacher Silvia; Houard Xavier; Berndt Sarah; Munaut Carine; Cataldo Didier; Alvarez Jesus; Melen-Lamalle Laurence; Foidart Jean-Michel; López-Otín Carlos; Noël Agnès
Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice.
Cancer research 2006;66(10):5234-41.
2006: Cal Santiago; Peinado Juan R; Llamazares María; Quesada Víctor; Moncada-Pazos Angela; Garabaya Cecilia; López-Otín Carlos
Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain.
BMC biochemistry 2006;7():9.
2006: Puente Xose S; Velasco Gloria; Gutiérrez-Fernández Ana; Bertranpetit Jaume; King Mary-Claire; López-Otín Carlos
Comparative analysis of cancer genes in the human and chimpanzee genomes.
BMC genomics 2006;7():15.
2005: Cadiñanos Juan; Varela Ignacio; López-Otín Carlos; Freije José M P
From immature lamin to premature aging: molecular pathways and therapeutic opportunities.
Cell cycle (Georgetown, Tex.) 2005;4(12):1732-5.
2005: Puente Xose S; Gutiérrez-Fernández Ana; Ordóñez Gonzalo R; Hillier LaDeana W; López-Otín Carlos
Comparative genomic analysis of human and chimpanzee proteases.
Genomics 2005;86(6):638-47.
2005: Levy Nicolas; López-Otín Carlos; Hennekam Raoul C M
Defective prelamin A processing resulting from LMNA or ZMPSTE24 mutations as the cause of restrictive dermopathy.
Archives of dermatology 2005;141(11):1473-4; author reply 1474.
2005: Kennedy Ann M; Inada Masaki; Krane Stephen M; Christie Paul T; Harding Brian; López-Otín Carlos; Sánchez Luis M; Pannett Anna A J; Dearlove Andrew; Hartley Claire; Byrne Michael H; Reed Anita A C; Nesbit M Andrew; Whyte Michael P; Thakker Rajesh V
MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO).
The Journal of clinical investigation 2005;115(10):2832-42.
2005: Varela Ignacio; Cadiñanos Juan; Pendás Alberto M; Gutiérrez-Fernández Ana; Folgueras Alicia R; Sánchez Luis M; Zhou Zhongjun; Rodríguez Francisco J; Stewart Colin L; Vega José A; Tryggvason Karl; Freije José M P; López-Otín Carlos
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
Nature 2005;437(7058):564-8.
2005: Díaz-Perales Araceli; Quesada Víctor; Peinado Juan R; Ugalde Alejandro P; Alvarez Jesús; Suárez María F; Gomis-Rüth F Xavier; López-Otín Carlos
Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea.
The Journal of biological chemistry 2005;280(34):30367-75.
2005: Liu Baohua; Wang Jianming; Chan Kui Ming; Tjia Wai Mui; Deng Wen; Guan Xinyuan; Huang Jian-dong; Li Kai Man; Chau Pui Yin; Chen David J; Pei Duanqing; Pendas Alberto M; Cadiñanos Juan; López-Otín Carlos; Tse Hung Fat; Hutchison Chris; Chen Junjie; Cao Yihai; Cheah Kathryn S E; Tryggvason Karl; Zhou Zhongjun
Genomic instability in laminopathy-based premature aging.
Nature medicine 2005;11(7):780-5.
2005: Navarro Claire L; Cadiñanos Juan; De Sandre-Giovannoli Annachiara; Bernard Rafaëlle; Courrier Sébastien; Boccaccio Irène; Boyer Amandine; Kleijer Wim J; Wagner Anja; Giuliano Fabienne; Beemer Frits A; Freije Jose M; Cau Pierre; Hennekam Raoul C M; López-Otín Carlos; Badens Catherine; Lévy Nicolas
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.
Human molecular genetics 2005;14(11):1503-13.
2005: Puente X S; Sánchez L M; Gutiérrez-Fernández A; Velasco G; López-Otín C
A genomic view of the complexity of mammalian proteolytic systems.
Biochemical Society transactions 2005;33(Pt 2):331-4.
2005: Díaz-Perales Araceli; Quesada Víctor; Sánchez Luis M; Ugalde Alejandro P; Suárez María F; Fueyo Antonio; López-Otín Carlos
Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase.
The Journal of biological chemistry 2005;280(14):14310-7.
2005: Cal Santiago; Quesada Víctor; Llamazares María; Díaz-Perales Araceli; Garabaya Cecilia; López-Otín Carlos
Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain.
The Journal of biological chemistry 2005;280(3):1953-61.
2004: Inada Masaki; Wang Yingmin; Byrne Michael H; Rahman Mahboob U; Miyaura Chisato; López-Otín Carlos; Krane Stephen M
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17192-7.
2004: Overall Christopher M; Tam Eric M; Kappelhoff Reinhild; Connor Andrea; Ewart Tom; Morrison Charlotte J; Puente Xose; López-Otín Carlos; Seth Arun
Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.
Biological chemistry 2004;385(6):493-504.
2004: Mariño G; López-Otín C
Autophagy: molecular mechanisms, physiological functions and relevance in human pathology.
Cellular and molecular life sciences : CMLS 2004;61(12):1439-54.
2004: Pendás Alberto M; Folgueras Alicia R; Llano Elena; Caterina John; Frerard Françoise; Rodríguez Francisco; Astudillo Aurora; Noël Agnès; Birkedal-Hansen Henning; López-Otín Carlos
Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice.
Molecular and cellular biology 2004;24(12):5304-13.
2004: Quesada Víctor; Sánchez Luis M; Alvarez Jesús; López-Otín Carlos
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
The Journal of biological chemistry 2004;279(25):26627-34.
2004: Puente Xose S; López-Otín Carlos
A genomic analysis of rat proteases and protease inhibitors.
Genome research 2004;14(4):609-22.
2004: Quesada Víctor; Díaz-Perales Araceli; Gutiérrez-Fernández Ana; Garabaya Cecilia; Cal Santiago; López-Otín Carlos
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.
Biochemical and biophysical research communications 2004;314(1):54-62.
2004: Folgueras Alicia R; Pendás Alberto M; Sánchez Luis M; López-Otín Carlos
Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.
The International journal of developmental biology 2004;48(5-6):411-24.
2003: Hieta Niina; Impola Ulla; López-Otín Carlos; Saarialho-Kere Ulpu; Kähäri Veli-Matti
Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture.
The Journal of investigative dermatology 2003;121(5):997-1004.
2003: Balbín Milagros; Fueyo Antonio; Tester Angus M; Pendás Alberto M; Pitiot Ana S; Astudillo Aurora; Overall Christopher M; Shapiro Steven D; López-Otín Carlos
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.
Nature genetics 2003;35(3):252-7.
2003: Cadiñanos Juan; Varela Ignacio; Mandel Daniel A; Schmidt Walter K; Díaz-Perales Araceli; López-Otín Carlos; Freije José M P
AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.
The Journal of biological chemistry 2003;278(43):42091-7.
2003: Puente Xose S; Sánchez Luis M; Overall Christopher M; López-Otín Carlos
Human and mouse proteases: a comparative genomic approach.
Nature reviews. Genetics 2003;4(7):544-58.
2003: Llamazares Maria; Cal Santiago; Quesada Víctor; López-Otín Carlos
Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.
The Journal of biological chemistry 2003;278(15):13382-9.
2003: Cadiñanos Juan; Schmidt Walter K; Fueyo Antonio; Varela Ignacio; López-Otín Carlos; Freije José M P
Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.
The Biochemical journal 2003;370(Pt 3):1047-54.
2003: Mariño Guillermo; Uría José A; Puente Xose S; Quesada Víctor; Bordallo Javier; López-Otín Carlos
Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
The Journal of biological chemistry 2003;278(6):3671-8.
2003: Freije José M P; Balbín Milagros; Pendás Alberto M; Sánchez Luis M; Puente Xose S; López-Otín Carlos
Matrix metalloproteinases and tumor progression.
Advances in experimental medicine and biology 2003;532():91-107.
2002: Zaragoza Carlos; Soria Estrella; López Esther; Browning Darren; Balbín Milagros; López-Otín Carlos; Lamas Santiago
Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells.
Molecular pharmacology 2002;62(4):927-35.
2002: Velasco Gloria; Cal Santiago; Quesada Victor; Sánchez Luis M; López-Otín Carlos
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.
The Journal of biological chemistry 2002;277(40):37637-46.
2002: Overall Christopher Mark; López-Otín Carlos
Strategies for MMP inhibition in cancer: innovations for the post-trial era.
Nature reviews. Cancer 2002;2(9):657-72.
2002: López-Otín Carlos; Overall Christopher M
Protease degradomics: a new challenge for proteomics.
Nature reviews. Molecular cell biology 2002;3(7):509-19.
2002: Llano Elena; Adam Geza; Pendás Alberto M; Quesada Víctor; Sánchez Luis M; Santamariá Iñigo; Noselli Stéphane; López-Otín Carlos
Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.
The Journal of biological chemistry 2002;277(26):23321-9.
2002: Pendás Alberto M; Zhou Zhongjun; Cadiñanos Juan; Freije José M P; Wang Jianming; Hultenby Kjell; Astudillo Aurora; Wernerson Annika; Rodríguez Francisco; Tryggvason Karl; López-Otín Carlos
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
Nature genetics 2002;31(1):94-9.
2002: Zaragoza Carlos; Balbín Milagros; López-Otín Carlos; Lamas Santiago
Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium.
Kidney international 2002;61(3):804-8.
2002: Cal Santiago; Obaya Alvaro J; Llamazares María; Garabaya Cecilia; Quesada Víctor; López-Otín Carlos
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Gene 2002;283(1-2):49-62.
2001: Jiménez M J; Balbín M; Alvarez J; Komori T; Bianco P; Holmbeck K; Birkedal-Hansen H; López J M; López-Otín C
A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation.
The Journal of cell biology 2001;155(7):1333-44.
2001: Cal S; Arguelles J M; Fernandez P L; López-Otín C
Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats.
The Journal of biological chemistry 2001;276(21):17932-40.
2001: Balbín M; Fueyo A; Knäuper V; López J M; Alvarez J; Sánchez L M; Quesada V; Bordallo J; Murphy G; López-Otín C
Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.
The Journal of biological chemistry 2001;276(13):10253-62.
2001: Velasco G; López-Otín C
Strategies for cloning new MMPs and TIMPs.
Methods in molecular biology (Clifton, N.J.) 2001;151():25-44.
2000: Llano E; Pendás A M; Aza-Blanc P; Kornberg T B; López-Otín C
Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development.
The Journal of biological chemistry 2000;275(46):35978-85.
2000: Uría J A; López-Otín C
Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity.
Cancer research 2000;60(17):4745-51.
2000: Cal S; Freije J M; López J M; Takada Y; López-Otín C
ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism.
Molecular biology of the cell 2000;11(4):1457-69.
2000: Velasco G; Cal S; Merlos-Suárez A; Ferrando A A; Alvarez S; Nakano A; Arribas J; López-Otín C
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.
Cancer research 2000;60(4):877-82.
2000: Pendás A M; Uría J A; Jiménez M G; Balbín M; Freije J P; López-Otín C
An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.
Clinica chimica acta; international journal of clinical chemistry 2000;291(2):137-55.
2000: Ala-aho R; Johansson N; Grénman R; Fusenig N E; López-Otín C; Kähäri V M
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1.
Oncogene 2000;19(2):248-57.
2000: Johansson N; Ala-aho R; Uitto V; Grénman R; Fusenig N E; López-Otín C; Kähäri V M
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.
Journal of cell science 2000;113 Pt 2():227-35.
1999: Murphy G; Knäuper V; Cowell S; Hembry R; Stanton H; Butler G; Freije J; Pendás A M; López-Otín C
Evaluation of some newer matrix metalloproteinases.
Annals of the New York Academy of Sciences 1999;878():25-39.
1999: Freije J M; Blay P; Pendás A M; Cadiñanos J; Crespo P; López-Otín C
Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.
Genomics 1999;58(3):270-80.
1999: Jiménez M J; Balbín M; López J M; Alvarez J; Komori T; López-Otín C
Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation.
Molecular and cellular biology 1999;19(6):4431-42.
1999: Santamaría I; Velasco G; Pendás A M; Paz A; López-Otín C
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.
The Journal of biological chemistry 1999;274(20):13800-9.
1999: Velasco G; Pendás A M; Fueyo A; Knäuper V; Murphy G; López-Otín C
Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members.
The Journal of biological chemistry 1999;274(8):4570-6.
1999: Balbín M; Pendás A M; Uría J A; Jiménez M G; Freije J P; López-Otín C
Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999;107(1):45-53.
1999: Ravanti L; Heino J; López-Otín C; Kähäri V M
Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.
The Journal of biological chemistry 1999;274(4):2446-55.
1998: Puente X S; Pendás A M; Llano E; López-Otín C
Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24.
Genomics 1998;54(3):578-9.
1998: Cazorla M; Hernández L; Nadal A; Balbín M; López J M; Vizoso F; Fernández P L; Iwata K; Cardesa A; López-Otín C; Campo E
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
The Journal of pathology 1998;186(2):144-50.
1998: Santamaría I; Pendás A M; Velasco G; López-Otín C
Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
Genomics 1998;53(2):231-4.
1998: Balbín M; Fueyo A; Knäuper V; Pendás A M; López J M; Jiménez M G; Murphy G; López-Otín C
Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus.
The Journal of biological chemistry 1998;273(37):23959-68.
1998: Puente X S; Pendás A M; López-otín C
Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL).
Genomics 1998;51(3):459-62.
1998: Uría J A; Balbín M; López J M; Alvarez J; Vizoso F; Takigawa M; López-Otín C
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
The American journal of pathology 1998;153(1):91-101.
1998: Santamaría I; Velasco G; Pendás A M; Fueyo A; López-Otín C
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.
The Journal of biological chemistry 1998;273(27):16816-23.
1998: Uitto V J; Airola K; Vaalamo M; Johansson N; Putnins E E; Firth J D; Salonen J; López-Otín C; Saarialho-Kere U; Kähäri V M
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.
The American journal of pathology 1998;152(6):1489-99.
1998: Santamaría I; Velasco G; Cazorla M; Fueyo A; Campo E; López-Otín C
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
Cancer research 1998;58(8):1624-30.
1998: Uría J A; Jiménez M G; Balbín M; Freije J M; López-Otín C
Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts.
The Journal of biological chemistry 1998;273(16):9769-77.
1998: Cowell S; Knäuper V; Stewart M L; D'Ortho M P; Stanton H; Hembry R M; López-Otín C; Reynolds J J; Murphy G
Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.
The Biochemical journal 1998;331 ( Pt 2)():453-8.
1997: Ferrando A A; Pendás A M; Llano E; Velasco G; Lidereau R; López-Otín C
Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase.
The Journal of biological chemistry 1997;272(52):33298-304.
1997: Llano E; Pendás A M; Knäuper V; Sorsa T; Salo T; Salido E; Murphy G; Simmer J P; Bartlett J D; López-Otín C
Identification and structural and functional characterization of human enamelysin (MMP-20).
Biochemistry 1997;36(49):15101-8.
1997: Uría J A; Ståhle-Bäckdahl M; Seiki M; Fueyo A; López-Otín C
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.
Cancer research 1997;57(21):4882-8.
1997: López-Boado Y S; Puente X S; Alvarez S; Tolivia J; Binderup L; López-Otín C
Growth inhibition of human breast cancer cells by 1,25-dihydroxyvitamin D3 is accompanied by induction of apolipoprotein D expression.
Cancer research 1997;57(18):4091-7.
1997: Ståhle-Bäckdahl M; Sandstedt B; Bruce K; Lindahl A; Jiménez M G; Vega J A; López-Otín C
Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.
Laboratory investigation; a journal of technical methods and pathology 1997;76(5):717-28.
1997: Puente X S; López-Otín C
The PLEES proteins: a family of structurally related enzymes widely distributed from bacteria to humans.
The Biochemical journal 1997;322 ( Pt 3)():947-9.
1997: Pendás A M; Balbín M; Llano E; Jiménez M G; López-Otín C
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13).
Genomics 1997;40(2):222-33.
1997: Johansson N; Westermarck J; Leppä S; Häkkinen L; Koivisto L; López-Otín C; Peltonen J; Heino J; Kähäri V M
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(2):243-50.
1997: Pendás A M; Knäuper V; Puente X S; Llano E; Mattei M G; Apte S; Murphy G; López-Otín C
Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution.
The Journal of biological chemistry 1997;272(7):4281-6.
1996: López-Boado Y S; Klaus M; Dawson M I; López-Otín C
Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RARalpha-dependent signaling pathway.
The Journal of biological chemistry 1996;271(50):32105-11.
1996: Pendás A M; Santamaría I; Alvarez M V; Pritchard M; López-Otín C
Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.
Genomics 1996;37(2):266-8.
1996: Balbín M; Fueyo A; López J M; Díez-Itza I; Velasco G; López-Otín C
Expression of collagenase-3 in the rat ovary during the ovulatory process.
The Journal of endocrinology 1996;149(3):405-15.
1996: Balbín M; Hannon G J; Pendás A M; Ferrando A A; Vizoso F; Fueyo A; López-Otín C
Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.
The Journal of biological chemistry 1996;271(26):15782-6.
1996: Balbín M; López-Otín C
Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone.
The Journal of biological chemistry 1996;271(25):15175-81.
1996: Uría J A; Fueyo A; Balbín M; Velasco G; Pendás A M; López-Otín C
Alternative splicing gives rise to two novel long isoforms of Zn-alpha 2-glycoprotein, a member of the immunoglobulin superfamily.
Gene 1996;169(2):233-6.
1996: Puente X S; Pendás A M; Llano E; Velasco G; López-Otín C
Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.
Cancer research 1996;56(5):944-9.
1996: Ferrando A A; Balbín M; Pendás A M; Vizoso F; Velasco G; López-Otín C
Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas.
Human genetics 1996;97(1):91-4.
1995: Ferreras M; Gavilanes J G; López-Otín C; García-Segura J M
Thiol-disulfide exchange of ribonuclease inhibitor bound to ribonuclease A. Evidence of active inhibitor-bound ribonuclease.
The Journal of biological chemistry 1995;270(48):28570-8.
1995: Puente X S; López-Otín C
Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds.
The Journal of biological chemistry 1995;270(21):12926-32.
1995: Pendás A M; Matilla T; Estivill X; López-Otín C
The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family.
Genomics 1995;26(3):615-8.
1995: Simón-Mateo C; Freije J M; Andrés G; López-Otín C; Viñuela E
Mapping and sequence of the gene encoding protein p17, a major African swine fever virus structural protein.
Virology 1995;206(2):1140-4.
1995: Vizoso F; Sánchez L M; Díez-Itza I; Merino A M; López-Otín C
Pepsinogen C is a new prognostic marker in primary breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(1):54-61.
1994: Velasco G; Ferrando A A; Puente X S; Sánchez L M; López-Otín C
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
The Journal of biological chemistry 1994;269(43):27136-42.
1994: López-Boado Y S; Tolivia J; López-Otín C
Apolipoprotein D gene induction by retinoic acid is concomitant with growth arrest and cell differentiation in human breast cancer cells.
The Journal of biological chemistry 1994;269(43):26871-8.
1994: Balbín M; Hall A; Grubb A; Mason R W; López-Otín C; Abrahamson M
Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases.
The Journal of biological chemistry 1994;269(37):23156-62.
1994: Fueyo A; Uría J A; Freije J M; López-Otín C
Cloning and expression analysis of the cDNA encoding rat Zn-alpha 2-glycoprotein.
Gene 1994;145(2):245-9.
1994: Vizoso F; Díez-Itza I; Sánchez L M; Tuya A F; Ruibal A; López-Otín C
Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women.
The Journal of clinical endocrinology and metabolism 1994;79(2):525-9.
1994: Freije J M; Díez-Itza I; Balbín M; Sánchez L M; Blasco R; Tolivia J; López-Otín C
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
The Journal of biological chemistry 1994;269(24):16766-73.
1994: Lacadena J; Martínez del Pozo A; Barbero J L; Mancheño J M; Gasset M; Oñaderra M; López-Otín C; Ortega S; García J; Gavilanes J G
Overproduction and purification of biologically active native fungal alpha-sarcin in Escherichia coli.
Gene 1994;142(1):147-51.
1994: Uría J A; Ferrando A A; Velasco G; Freije J M; López-Otín C
Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.
Cancer research 1994;54(8):2091-4.
1994: Batanero E; Villalba M; López-Otín C; Rodríguez R
Isolation and characterization of an olive allergen-like protein from lilac pollen. Sequence analysis of three cDNA encoding protein isoforms.
European journal of biochemistry / FEBS 1994;221(1):187-93.
1994: Díez-Itza I; Vizoso F; Merino A M; Sánchez L M; Tolivia J; Fernández J; Ruibal A; López-Otín C
Expression and prognostic significance of apolipoprotein D in breast cancer.
The American journal of pathology 1994;144(2):310-20.
1994: Pendás A M; Matilla T; Uría J A; Freije J P; Fueyo A; Estivill X; López-Otín C
Mapping of the human Zn-alpha 2-glycoprotein gene (AZGP1) to chromosome 7q22 by in situ hybridization.
Cytogenetics and cell genetics 1994;66(4):263-6.
1994: López-Boado Y S; Díez-Itza I; Tolivia J; López-Otín C
Glucocorticoids and androgens up-regulate the Zn-alpha 2-glycoprotein messenger RNA in human breast cancer cells.
Breast cancer research and treatment 1994;29(3):247-58.
1993: Freije J P; Fueyo A; Uría J A; Velasco G; Sánchez L M; López-Boado Y S; López-Otín C
Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes.
Genomics 1993;18(3):575-87.
1993: Freije J M; Laín S; Viñuela E; López-Otín C
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Virus research 1993;30(1):63-72.
1993: Villalba M; Batanero E; López-Otín C; Sánchez L M; Monsalve R I; González de la Peña M A; Lahoz C; Rodríguez R
The amino acid sequence of Ole e I, the major allergen from olive tree (Olea europaea) pollen.
European journal of biochemistry / FEBS 1993;216(3):863-9.
1993: Diez-Itza I; Merino A M; Tolivia J; Vizoso F; Sánchez L M; López-Otín C
Expression of pepsinogen C in human breast tumours and correlation with clinicopathologic parameters.
British journal of cancer 1993;68(3):637-40.
1993: García J A; Cervera M T; Riechmann J L; López-Otín C
Inhibitory effects of human cystatin C on plum pox potyvirus proteases.
Plant molecular biology 1993;22(4):697-701.
1993: Freije J P; Balbín M; Abrahamson M; Velasco G; Dalbøge H; Grubb A; López-Otín C
Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva.
The Journal of biological chemistry 1993;268(21):15737-44.
1993: Balbín M; Freije J P; Abrahamson M; Velasco G; Grubb A; López-Otín C
A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level.
Human genetics 1993;90(6):668-9.
1993: Freije J M; Muñoz M; Viñuela E; López-Otín C
High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.
Gene 1993;123(2):259-62.
1993: Muñoz M; Freije J M; Salas M L; Viñuela E; López-Otín C
Structure and expression in E. coli of the gene coding for protein p10 of African swine fever virus.
Archives of virology 1993;130(1-2):93-107.
1993: Freije J P; Pendás A M; Velasco G; Roca A; Abrahamson M; López-Otín C
Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization.
Cytogenetics and cell genetics 1993;62(1):29-31.
1993: Díez-Itza I; Sánchez L M; Allende M T; Vizoso F; Ruibal A; López-Otín C
Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters.
European journal of cancer (Oxford, England : 1990) 1993;29A(9):1256-60.
1992: Sánchez L M; Freije J P; Merino A M; Vizoso F; Foltmann B; López-Otín C
Isolation and characterization of a pepsin C zymogen produced by human breast tissues.
The Journal of biological chemistry 1992;267(34):24725-31.
1992: Alcamí A; Angulo A; López-Otín C; Muñoz M; Freije J M; Carrascosa A L; Viñuela E
Amino acid sequence and structural properties of protein p12, an African swine fever virus attachment protein.
Journal of virology 1992;66(6):3860-8.
1992: García-Beato R; Freije J M; López-Otín C; Blasco R; Viñuela E; Salas M L
A gene homologous to topoisomerase II in African swine fever virus.
Virology 1992;188(2):938-47.
1992: Sánchez L M; Díez-Itza I; Vizoso F; López-Otín C
Cholesterol and apolipoprotein D in gross cystic disease of the breast.
Clinical chemistry 1992;38(5):695-8.
1992: Sánchez L M; Vizoso F; Díez-Itza I; López-Otín C
Identification of the major protein components in breast secretions from women with benign and malignant breast diseases.
Cancer research 1992;52(1):95-100.
1992: Sánchez L M; Vizoso F; Allende M T; Ruibal A; López-Otín C
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
European journal of cancer (Oxford, England : 1990) 1992;28A(4-5):828-32.
1992: Vizoso F; Sánchez L M; Díez-Itza I; Luz Lamelas M; López-Otín C
Factors affecting protein composition of breast secretions from nonlactating women.
Breast cancer research and treatment 1992;23(3):251-8.
1991: Freije J P; Abrahamson M; Olafsson I; Velasco G; Grubb A; López-Otín C
Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor.
The Journal of biological chemistry 1991;266(30):20538-43.
1991: Freije J M; Muñoz M; López-Otín C; Viñuela E
A general method to cleave a known DNA sequence at any site.
BioTechniques 1991;11(4):432-4, 436.
1991: Freije J P; Fueyo A; Uría J; López-Otín C
Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues.
FEBS letters 1991;290(1-2):247-9.
1991: Monsalve R I; Villalba M; López-Otín C; Rodríguez R
Structural analysis of the small chain of the 2S albumin, napin nIII, from rapeseed. Chemical and spectroscopic evidence of an intramolecular bond formation.
Biochimica et biophysica acta 1991;1078(2):265-72.
1991: Nieto A; Correas I; López-Otín C; Avila J
Tau-related protein present in paired helical filaments has a decreased tubulin binding capacity as compared with microtubule-associated protein tau.
Biochimica et biophysica acta 1991;1096(3):197-204.
1991: Balbín M; Vizoso F; Sánchez L M; Venta R; Ruibal A; Fueyo A; López-Otín C
GCDFP-70 protein in cyst fluid identified as albumin and used to classify cysts in women with breast gross cystic disease.
Clinical chemistry 1991;37(4):547-51.
1990: Balbín M; Freije J M; Fueyo A; Sánchez L M; López-Otín C
Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease.
The Biochemical journal 1990;271(3):803-7.
1990: Villalba M; López-Otín C; Martín-Orozco E; Monsalve R I; Palomino P; Lahoz C; Rodríguez R
Isolation of three allergenic fractions of the major allergen from Olea europea pollen and N-terminal amino acid sequence.
Biochemical and biophysical research communications 1990;172(2):523-8.
1990: Blasco R; López-Otín C; Muñóz M; Bockamp E O; Simón-Mateo C; Viñuela E
Sequence and evolutionary relationships of African swine fever virus thymidine kinase.
Virology 1990;178(1):301-4.
1990: López-Otín C; Freije J M; Parra F; Méndez E; Viñuela E
Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus.
Virology 1990;175(2):477-84.
1990: Monsalve R I; Menéndez-Arias L; López-Otín C; Rodríguez R
Beta-turns as structural motifs for the proteolytic processing of seed proteins.
FEBS letters 1990;263(2):209-12.
1990: Martín M T; López Otín C; Laín S; García J A
Determination of polyprotein processing sites by amino terminal sequencing of nonstructural proteins encoded by plum pox potyvirus.
Virus research 1990;15(2):97-106.
1989: López-Otín C; Simón-Mateo C; Martínez L; Viñuela E
Gly-Gly-X, a novel consensus sequence for the proteolytic processing of viral and cellular proteins.
The Journal of biological chemistry 1989;264(16):9107-10.
1988: López-Otín C; Simón C; Méndez E; Viñuela E
Mapping and sequence of the gene encoding protein p37, a major structural protein of African swine fever virus.
Virus genes 1988;1(3):291-303.

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