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Francisco López

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Eric G Vajda; Francisco J López; Peter Rix; Robert Hill; Yanling Chen; Kyoung-Jin Lee; Z O'Brien; William Y Chang; Martin D Meglasson; Yong-Hee Lee
Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator.
Eric G Vajda; Aimee Hogue; Kimberly N Griffiths; William Y Chang; Kelven Burnett; Yanling Chen; Keith B Marschke; Dale E Mais; Bijan Pedram; Yixing Shen; Arjan van Oeveren; Lin Zhi; Francisco J López; Martin D Meglasson
Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats.
Yun Oliver Long; Robert I Higuchi; Thomas R Caferro; Thomas L S Lau; Min Wu; Marquis L Cummings; Esther Martinborough; Keith B Marschke; William Y Chang; Francisco J López; Donald S Karanewsky; Lin Zhi
Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity.

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All Publications

2009: Eric G Vajda; Francisco J López; Peter Rix; Robert Hill; Yanling Chen; Kyoung-Jin Lee; Z O'Brien; William Y Chang; Martin D Meglasson; Yong-Hee Lee
Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator.
The Journal of pharmacology and experimental therapeutics 2009;328(2):663-70.
2009: Eric G Vajda; Aimee Hogue; Kimberly N Griffiths; William Y Chang; Kelven Burnett; Yanling Chen; Keith B Marschke; Dale E Mais; Bijan Pedram; Yixing Shen; Arjan van Oeveren; Lin Zhi; Francisco J López; Martin D Meglasson
Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(2):231-40.
2008: Yun Oliver Long; Robert I Higuchi; Thomas R Caferro; Thomas L S Lau; Min Wu; Marquis L Cummings; Esther Martinborough; Keith B Marschke; William Y Chang; Francisco J López; Donald S Karanewsky; Lin Zhi
Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity.
Bioorganic & medicinal chemistry letters 2008;18(9):2967-71.
2008: Francisco J López; Robert J Ardecky; Bruce Bebo; Khalid Benbatoul; Louise De Grandpre; Sha Liu; Mark D Leibowitz; Keith B Marschke; Jon Rosen; Deepa Rungta; Humberto O Viveros; Wan-Ching Yen; Lin Zhi; Andrés Negro-Vilar; Jeffrey N Miner
LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo.
Endocrinology 2008;149(5):2080-9.
2008: Brian J Arey; Stephen D Yanofsky; M Claudia Pérez; Christopher P Holmes; Jay Wrobel; Ariamala Gopalsamy; Panayiotis E Stevis; Francisco J López; Richard Winneker
Differing pharmacological activities of thiazolidinone analogs at the FSH receptor.
Biochemical and biophysical research communications 2008;368(3):723-8.
2007: Esther Martinborough; Yixing Shen; Arjan van Oeveren; Yun Oliver Long; Thomas L S Lau; Keith B Marschke; William Y Chang; Francisco J López; Eric G Vajda; Peter J Rix; O Humberto Viveros; Andrés Negro-Vilar; Lin Zhi
Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.
Journal of medicinal chemistry 2007;50(21):5049-52.
2007: Robert I Higuchi; Anthony W Thompson; Jyun-Hung Chen; Thomas R Caferro; Marquis L Cummings; Charlotte P Deckhut; Mark E Adams; Christopher M Tegley; James P Edwards; Francisco J López; E Adam Kallel; Donald S Karanewsky; William T Schrader; Keith B Marschke; Lin Zhi
Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.
Bioorganic & medicinal chemistry letters 2007;17(19):5442-6.
2007: Robert I Higuchi; Kristen L Arienti; Francisco J López; Neelakandha S Mani; Dale E Mais; Thomas R Caferro; Yun Oliver Long; Todd K Jones; James P Edwards; Lin Zhi; William T Schrader; Andrés Negro-Vilar; Keith B Marschke
Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.
Journal of medicinal chemistry 2007;50(10):2486-96.
2007: Arjan van Oeveren; Mehrnouch Motamedi; Esther Martinborough; Shuo Zhao; Yixing Shen; Sarah West; William Chang; Adam Kallel; Keith B Marschke; Francisco J López; Andrés Negro-Vilar; Lin Zhi
Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones.
Bioorganic & medicinal chemistry letters 2007;17(6):1527-31.
2007: Jeffrey N Miner; William Chang; Mark S Chapman; Patricia D Finn; Mei Hua Hong; Francisco J López; Keith B Marschke; Jon Rosen; William T Schrader; Russell Turner; Arjan van Oeveren; Humberto Viveros; Lin Zhi; Andrés Negro-Vilar
An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate.
Endocrinology 2007;148(1):363-73.
2006: Arjan van Oeveren; Mehrnouch Motamedi; Neelakandha S Mani; Keith B Marschke; Francisco J López; William T Schrader; Andrés Negro-Vilar; Lin Zhi
Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.
Journal of medicinal chemistry 2006;49(21):6143-6.
2006: Stephen D Yanofsky; Emily S Shen; Frank Holden; Erik Whitehorn; Barbara Aguilar; Emily Tate; Christopher P Holmes; Randall A Scheuerman; Derek Maclean; May M Wu; Donald E Frail; Francisco J López; Richard Winneker; Brian J Arey; Ronald W Barrett
Allosteric activation of the follicle-stimulating hormone (FSH) receptor by selective, nonpeptide agonists.
The Journal of biological chemistry 2006;281(19):13226-33.
2002: Brian J Arey; Darlene C Deecher; Emily S Shen; Panayiotis E Stevis; Edwin H Meade; Jay Wrobel; Donald E Frail; Francisco J López
Identification and characterization of a selective, nonpeptide follicle-stimulating hormone receptor antagonist.
Endocrinology 2002;143(10):3822-9.
2002: Darlene C Deecher; Francisco J López
Discrimination of galanin receptor subtypes in RINm5F cells by structurally different galanin radioligands.
Peptides 2002;23(3):545-53.
2002: Jay Wrobel; Daniel Green; James Jetter; Wenling Kao; John Rogers; M Claudia Pérez; Jill Hardenburg; Darlene C Deecher; Francisco J López; Brian J Arey; Emily S Shen
Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists.
Bioorganic & medicinal chemistry 2002;10(3):639-56.
1999: Emily S Shen; Jill Hardenburg; Edwin H Meade; Brian J Arey; Istvan Merchenthaler; Francisco J López
Estradiol induces galanin gene expression in the pituitary of the mouse in an estrogen receptor alpha-dependent manner.
Endocrinology 1999;140(6):2628-31.
1998: K Ghosh; Emily S Shen; Brian J Arey; Francisco J López
A global model to define the behavior of partial agonists (bell-shaped dose-response inducers) in pharmacological evaluation of activity in the presence of the full agonist.
Journal of biopharmaceutical statistics 1998;8(4):645-65.
1998: Emily S Shen; Edwin H Meade; M C Pérez; Darlene C Deecher; Andrés Negro-Vilar; Francisco J López
Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: estrogenic control of galanin gene expression.
Endocrinology 1998;139(3):939-48.
1998: Francisco J López; Istvan Merchenthaler; M Moretto; Andrés Negro-Vilar
Modulating mechanisms of neuroendocrine cell activity: the LHRH pulse generator.
Cellular and molecular neurobiology 1998;18(1):125-46.
1996: Francisco J López; Istvan Merchenthaler; Zsolt Liposits; andres negro vilar
Steroid imprinting and modulation of sexual dimorphism in the luteinizing hormone-releasing hormone neuronal system.
Cellular and molecular neurobiology 1996;16(2):129-41.
1994: A O Donoso; A M Seltzer; C E Navarro; R J Cabrera; Francisco J López; andres negro vilar
Regulation of luteinizing hormone-releasing hormone and luteinizing hormone secretion by hypothalamic amino acids.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(4):921-32.
1993: Istvan Merchenthaler; D E Lennard; Francisco J López; Andrés Negro-Vilar
Neonatal imprinting predetermines the sexually dimorphic, estrogen-dependent expression of galanin in luteinizing hormone-releasing hormone neurons.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10479-83.
1993: M Moretto; Francisco J López; Andrés Negro-Vilar
Nitric oxide regulates luteinizing hormone-releasing hormone secretion.
Endocrinology 1993;133(5):2399-402.
1993: Istvan Merchenthaler; Francisco J López; Andrés Negro-Vilar
Anatomy and physiology of central galanin-containing pathways.
Progress in neurobiology 1993;40(6):711-69.
1993: M Moretto; Francisco J López; Andrés Negro-Vilar
Endothelin-3 stimulates luteinizing hormone-releasing hormone (LHRH) secretion from LHRH neurons by a prostaglandin-dependent mechanism.
Endocrinology 1993;132(2):789-94.
1993: Francisco J López; Edwin H Meade; Andrés Negro-Vilar
Endogenous galanin modulates the gonadotropin and prolactin proestrous surges in the rat.
Endocrinology 1993;132(2):795-800.
1992: A O Donoso; Francisco J López; Andrés Negro-Vilar
Cross-talk between excitatory and inhibitory amino acids in the regulation of luteinizing hormone-releasing hormone secretion.
Endocrinology 1992;131(3):1559-61.
1992: José E Sánchez-Criado; Carmina Bellido; Francisco J López; F Galiot
Antiprogesterone RU486 induces dissociation of LH and FSH secretion in the cyclic rat: effect of anti-inhibin serum.
The Journal of endocrinology 1992;134(1):43-9.
1992: William C Wetsel; marcelo valenca; Istvan Merchenthaler; Zsolt Liposits; Francisco J López; R I Weiner; Pamela L Mellon; Andrés Negro-Vilar
Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):4149-53.
1992: Francisco J López; A O Donoso; Andrés Negro-Vilar
Endogenous excitatory amino acids and glutamate receptor subtypes involved in the control of hypothalamic luteinizing hormone-releasing hormone secretion.
Endocrinology 1992;130(4):1986-92.
1992: Francisco J López; Zsolt Liposits; Istvan Merchenthaler
Evidence for a negative ultrashort loop feedback regulating galanin release from the arcuate nucleus-median eminence functional unit.
Endocrinology 1992;130(3):1499-507.
1991: Istvan Merchenthaler; Francisco J López; D E Lennard; Andrés Negro-Vilar
Sexual differences in the distribution of neurons coexpressing galanin and luteinizing hormone-releasing hormone in the rat brain.
Endocrinology 1991;129(4):1977-86.
1991: Francisco J López; José E Sánchez-Criado; Andrés Negro-Vilar
A physiological role for sporadic interruptions of the dopaminergic tone in the genesis of big mass prolactin pulses.
Endocrinology 1991;129(3):1471-80.
1991: Francisco J López; Istvan Merchenthaler; M Ching; M G Wisniewski; Andrés Negro-Vilar
Galanin: a hypothalamic-hypophysiotropic hormone modulating reproductive functions.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4508-12.
1990: José E Sánchez-Criado; Carmina Bellido; F Galiot; Francisco J López; Francisco Gaytán
A possible dual mechanism of the anovulatory action of antiprogesterone RU486 in the rat.
Biology of reproduction 1990;42(5-6):877-86.
1990: Francisco J López; A O Donoso; Andrés Negro-Vilar
Endogenous excitatory amino acid neurotransmission regulates the estradiol-induced LH surge in ovariectomized rats.
Endocrinology 1990;126(3):1771-3.
1990: Leonor Pinilla; Francisco J López; Enrique Aguilar
The effect of orchidectomy on rat pituitary responsiveness to GHRH depends on age.
Acta endocrinologica 1990;122(3):349-53.
1990: Francisco J López; Edwin H Meade; Andrés Negro-Vilar
Development and characterization of a specific and sensitive radioimmunoassay for rat galanin: measurement in brain tissue, hypophyseal portal and peripheral serum.
Brain research bulletin 1990;24(3):395-9.
1990: A O Donoso; Francisco J López; Andrés Negro-Vilar
Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone-releasing hormone release by excitatory amino acids in vitro.
Endocrinology 1990;126(1):414-20.
1989: Francisco J López; J R Dominguez; José E Sánchez-Criado; Andrés Negro-Vilar
Distinct pulsatile prolactin secretory patterns during the estrous cycle: possible encoding for diverse physiological responses.
Endocrinology 1989;124(1):536-42.
1989: Francisco J López; J R Dominguez; F Sánchez-Franco; Andrés Negro-Vilar
Role of dopamine and vasoactive intestinal peptide in the control of pulsatile prolactin secretion.
Endocrinology 1989;124(1):527-35.
1988: Francisco J López; Andrés Negro-Vilar
Estimation of endogenous adrenocorticotropin half-life using pulsatility patterns: a physiological approach to the evaluation of secretory episodes.
Endocrinology 1988;123(2):740-6.