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Michael Lord

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Shuyu Li; J Michael Lord; Randolph Y Hampton; Robert A Spooner; Lynne M Roberts
Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p.
Robert A Spooner; J Michael Lord
How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum.
J Michael Lord; Robert A Spooner
Ricin trafficking in plant and mammalian cells.

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All Publications

2012: Shuyu Li; J Michael Lord; Randolph Y Hampton; Robert A Spooner; Lynne M Roberts
Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p.
PloS one 2012;7(7):e41119.
2012: Robert A Spooner; J Michael Lord
How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum.
Current topics in microbiology and immunology 2012;357():19-40.
2011: J Michael Lord; Robert A Spooner
Ricin trafficking in plant and mammalian cells.
Toxins 2011;3(7):787-801.
2011: Douglas Carroll; J Michael Lord; Anna C Phillips; Wiebke Arlt; G D Batty
Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study.
Journal of human hypertension 2011;25(7):418-24.
2011: Vidya Pawar; Antara De; Laura Briggs; Mahmoud M Omar; Sean T Sweeney; J Michael Lord; Lynne M Roberts; Robert Spooner; Kevin G Moffat
RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance.
Journal of biomolecular screening 2011;16(4):436-42.
2011: Mina-Olga Aletrari; Sabine L Flitsch; Stephen High; J Michael Lord; Craig McKibbin; Vidya Pawar; Paola Pietroni; Eileithyia Swanton; Roger Whitehead; Helen Williams; Robert Spooner
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.
PloS one 2011;6(7):e22713.
2010: Lucie J Guetzoyan; Robert Spooner; Frédéric Boal; David J Stephens; J Michael Lord; Lynne M Roberts; Guy J Clarkson
Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells.
Molecular bioSystems 2010;6(10):2030-8.
2010: Shuyu Li; Robert Spooner; Stuart C H Allen; Christopher P Guise; Graham Ladds; Tina Schnöder; Manfred J Schmitt; J Michael Lord; Lynne M Roberts
Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
Molecular biology of the cell 2010;21(15):2543-54.
2009: See Heng Wong; N Francis; Hema Chahal; Karim Raza; Mike Salmon; Dagmar Scheel-Toellner; J Michael Lord
Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid.
Rheumatology (Oxford, England) 2009;48(1):39-44.
2008: Kerry L Chamberlain; Richard S Marshall; Nicholas A Jolliffe; Lorenzo Frigerio; Aldo Ceriotti; J Michael Lord; Lynne M Roberts
Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism.
The Journal of biological chemistry 2008;283(48):33276-86.
2008: Robert Spooner; Philip J Hart; Jonathan P Cook; Paola Pietroni; Christian Rogon; Jörg Höhfeld; Lynne M Roberts; J Michael Lord
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17408-13.
2008: Robert Spooner; Peter Watson; Daniel C Smith; Frédéric Boal; Mohamed Amessou; Ludger Johannes; Guy J Clarkson; J Michael Lord; David J Stephens; Lynne M Roberts
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.
The Biochemical journal 2008;414(3):471-84.
2008: Richard S Marshall; Nicholas A Jolliffe; Aldo Ceriotti; Christopher J Snowden; J Michael Lord; Lorenzo Frigerio; Lynne M Roberts
The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells.
The Journal of biological chemistry 2008;283(23):15869-77.
2008: Dagmar Scheel-Toellner; Karim Raza; Lakhvir Assi; Darrell Pilling; Emma J Ross; Wing Yiu Lee; S John Curnow; Christopher D Buckley; Arne N Akbar; J Michael Lord; Mike Salmon
Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.
Apoptosis : an international journal on programmed cell death 2008;13(1):109-17.
2007: Stuart C H Allen; Katherine A H Moore; Catherine J Marsden; Vilmos Fülöp; Kevin G Moffat; J Michael Lord; Graham Ladds; Lynne M Roberts
The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae.
The FEBS journal 2007;274(21):5586-99.
2007: Lakhvir Kaur Assi; See Heng Wong; Andreas Ludwig; Karim Raza; Caroline Gordon; Mike Salmon; J Michael Lord; Dagmar Scheel-Toellner
Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint.
Arthritis and rheumatism 2007;56(6):1776-86.
2007: Rosemary M Jarvis; Anita Chamba; Michelle J Holder; Anita Challa; Daniel C Smith; Matthew N Hodgkin; J Michael Lord; John Gordon
Dynamic interplay between the neutral glycosphingolipid CD77/Gb3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells.
Biochemical and biophysical research communications 2007;355(4):944-9.
2007: Mohamed Amessou; Alexandre Fradagrada; Thomas Falguières; J Michael Lord; Daniel C Smith; Lynne M Roberts; Christophe Lamaze; Ludger Johannes
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins.
Journal of cell science 2007;120(Pt 8):1457-68.
2007: Karim Raza; Dagmar Scheel-Toellner; J Michael Lord; Arne N Akbar; Christopher D Buckley; Mike Salmon
The assessment of T-cell apoptosis in synovial fluid.
Methods in molecular medicine 2007;136():117-38.
2007: Anna C Phillips; Victoria E Burns; J Michael Lord
Stress and exercise: Getting the balance right for aging immunity.
Exercise and sport sciences reviews 2007;35(1):35-9.
2006: Nicholas A Jolliffe; Alessandra Di Cola; Catherine J Marsden; J Michael Lord; Aldo Ceriotti; Lorenzo Frigerio; Lynne M Roberts
The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts.
The Journal of biological chemistry 2006;281(33):23377-85.
2006: Wiebke Arlt; Fabian Hammer; Petra Sanning; Stephen K Butcher; J Michael Lord; Bruno Allolio; Djillali Annane; Paul M Stewart
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
The Journal of clinical endocrinology and metabolism 2006;91(7):2548-54.
2006: Daniel C Smith; Robert Spooner; Peter D Watson; James L Murray; Thomas W Hodge; Mohamed Amessou; Ludger Johannes; J Michael Lord; Lynne M Roberts
Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum.
Traffic (Copenhagen, Denmark) 2006;7(4):379-93.
2006: Helen M McGettrick; J Michael Lord; Ke-Qing Wang; G Ed Rainger; Christopher D Buckley; Gerard B Nash
Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium.
Journal of leukocyte biology 2006;79(4):779-88.
2006: Daniel C Smith; Dan J Sillence; Thomas Falguières; Rosemary M Jarvis; Ludger Johannes; J Michael Lord; Frances M Platt; Lynne M Roberts
The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.
Molecular biology of the cell 2006;17(3):1375-87.
2006: Ewan A Ross; Michael R Douglas; See Heng Wong; Emma J Ross; S John Curnow; Gerard B Nash; Ed Rainger; Dagmar Scheel-Toellner; J Michael Lord; Mike Salmon; Christopher D Buckley
Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis.
Blood 2006;107(3):1178-83.
2006: Karim Raza; Dagmar Scheel-Toellner; Chi-Yeung Lee; Darrell Pilling; S John Curnow; Francesco Falciani; Victor Trevino; Kanta Kumar; Lakhvir Kaur Assi; J Michael Lord; Caroline Gordon; Christopher D Buckley; Mike Salmon
Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis.
Arthritis research & therapy 2006;8(4):R120.
2006: Robert Spooner; Daniel C Smith; Andrew J Easton; Lynne M Roberts; J Michael Lord
Retrograde transport pathways utilised by viruses and protein toxins.
Virology journal 2006;3():26.
2005: J Michael Lord; Lynne M Roberts; Colin J Stirling
Quality control: another player joins the ERAD cast.
Current biology : CB 2005;15(23):R963-4.
2005: Stuart C H Allen; Adam Byron; J Michael Lord; John Davey; Lynne M Roberts; Graham Ladds
Utilisation of the budding yeast Saccharomyces cerevisiae for the generation and isolation of non-lethal ricin A chain variants.
Yeast (Chichester, England) 2005;22(16):1287-97.
2005: Stephen K Butcher; Vijay Vardhan Killampalli; David Lascelles; Keqing Wang; E Kaya Alpar; J Michael Lord
Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity.
Aging cell 2005;4(6):319-24.
2005: Riccardo Vago; Catherine J Marsden; J Michael Lord; Rodolfo Ippoliti; David Flavell; Sopsamorn U Flavell; Aldo Ceriotti; Maura Fabbrini
Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.
The FEBS journal 2005;272(19):4983-95.
2005: Peter Hampson; Hema Chahal; Farhat L Khanim; Rachel E Hayden; Anneke Mulder; Lakhvir Kaur Assi; Christopher M Bunce; J Michael Lord
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Blood 2005;106(4):1362-8.
2005: Catherine J Marsden; Daniel C Smith; Lynne M Roberts; J Michael Lord
Ricin: current understanding and prospects for an antiricin vaccine.
Expert review of vaccines 2005;4(2):229-37.
2005: J Michael Lord; Stephen High
Polytopic proteins: preventing aggregation in the membrane.
Current biology : CB 2005;15(5):R169-71.
2005: J Michael Lord; Lynne M Roberts; W I Lencer
Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation.
Current topics in microbiology and immunology 2005;300():149-68.
2005: Karim Raza; Francesco Falciani; S John Curnow; Emma J Ross; Chi-Yeung Lee; Arne N Akbar; J Michael Lord; Caroline Gordon; Christopher D Buckley; Mike Salmon
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.
Arthritis research & therapy 2005;7(4):R784-95.
2005: Alessandra Di Cola; Lorenzo Frigerio; J Michael Lord; Lynne M Roberts; Aldo Ceriotti
Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features.
Plant physiology 2005;137(1):287-96.
2004: Dagmar Scheel-Toellner; Keqing Wang; Lakhvir Kaur Assi; Paul Webb; Rachel Craddock; Mike Salmon; J Michael Lord
Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis.
Biochemical Society transactions 2004;32(Pt 5):679-81.
2004: Dagmar Scheel-Toellner; Keqing Wang; Rachel Craddock; Paul Webb; Helen M McGettrick; Lakhvir Kaur Assi; Neal Parkes; Louise E Clough; Erich Gulbins; Mike Salmon; J Michael Lord
Reactive oxygen species limit neutrophil life span by activating death receptor signaling.
Blood 2004;104(8):2557-64.
2004: Robert Spooner; Peter D Watson; Catherine J Marsden; Daniel C Smith; Katherine A H Moore; Jonathan P Cook; J Michael Lord; Lynne M Roberts
Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum.
The Biochemical journal 2004;383(Pt 2):285-93.
2004: M R Hartley; J Michael Lord
Cytotoxic ribosome-inactivating lectins from plants.
Biochimica et biophysica acta 2004;1701(1-2):1-14.
2004: Stephen K Butcher; J Michael Lord
Stress responses and innate immunity: aging as a contributory factor.
Aging cell 2004;3(4):151-60.
2004: Daniel C Smith; Mariolina Salio; J Michael Lord; Lynne M Roberts; Vincenzo Cerundolo
Lack of dendritic cell maturation by the plant toxin ricin.
European journal of immunology 2004;34(8):2149-57.
2004: Daniel C Smith; J Michael Lord; Lynne M Roberts; Ludger Johannes
Glycosphingolipids as toxin receptors.
Seminars in cell & developmental biology 2004;15(4):397-408.
2004: Catherine J Marsden; Simon Knight; Daniel C Smith; Philip J Day; Lynne M Roberts; Gary J Phillips; J Michael Lord
Insertional mutagenesis of ricin A chain: a novel route to an anti-ricin vaccine.
Vaccine 2004;22(21-22):2800-5.
2004: Lynne M Roberts; J Michael Lord
Ribosome-inactivating proteins: entry into mammalian cells and intracellular routing.
Mini reviews in medicinal chemistry 2004;4(5):505-12.
2004: Martin R Hartley; J Michael Lord
Genetics of ribosome-inactivating proteins.
Mini reviews in medicinal chemistry 2004;4(5):487-92.
2004: Dagmar Scheel-Toellner; Ke-Qing Wang; Paul Webb; See Heng Wong; Rachel Craddock; Lakhvir Kaur Assi; Mike Salmon; J Michael Lord
Early events in spontaneous neutrophil apoptosis.
Biochemical Society transactions 2004;32(Pt3):461-4.
2004: Catherine J Marsden; Vilmos Fülöp; Philip J Day; J Michael Lord
The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain.
European journal of biochemistry / FEBS 2004;271(1):153-62.
2003: J Michael Lord; Emma D Deeks; Catherine J Marsden; K Moore; Cassandra S Pateman; Daniel C Smith; Robert Spooner; P Watson; Lynne M Roberts
Retrograde transport of toxins across the endoplasmic reticulum membrane.
Biochemical Society transactions 2003;31(Pt 6):1260-2.
2003: J Michael Lord
A physiological role for alpha2-HS glycoprotein: stimulation of macrophage uptake of apoptotic cells.
Clinical science (London, England : 1979) 2003;105(3):267-8.
2003: KeQing Wang; Dagmar Scheel-Toellner; See Heng Wong; Rachel Craddock; Jorge Caamano; Arne N Akbar; Mike Salmon; J Michael Lord
Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):1035-41.
2003: Stephen K Butcher; Vijay Vardhan Killampalli; Hema Chahal; E Kaya Alpar; J Michael Lord
Effect of age on susceptibility to post-traumatic infection in the elderly.
Biochemical Society transactions 2003;31(2):449-51.
2002: Dagmar Scheel-Toellner; Keqing Wang; R Singh; S Majeed; Karim Raza; S John Curnow; Mike Salmon; J Michael Lord
The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis.
Biochemical and biophysical research communications 2002;297(4):876-9.
2002: J Michael Lord; Lorenzo Frigerio
ER quality control: a function for sugars in the cytosol.
Current biology : CB 2002;12(19):R663-5.
2002: Daniel C Smith; J Michael Lord; Lynne M Roberts; Eric Tartour; Ludger Johannes
1st class ticket to class I: protein toxins as pathfinders for antigen presentation.
Traffic (Copenhagen, Denmark) 2002;3(10):697-704.
2002: Daniel C Smith; Awen Gallimore; Emma Jones; Brenda Roberts; J Michael Lord; Emma D Deeks; Vincenzo Cerundolo; Lynne M Roberts
Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):99-107.
2002: J Michael Lord; Arne N Akbar; David Kipling
Telomere-based therapy for immunosenescence.
Trends in immunology 2002;23(4):175-6.
2002: Emma D Deeks; Jonathan P Cook; Philip J Day; Daniel C Smith; Lynne M Roberts; J Michael Lord
The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol.
Biochemistry 2002;41(10):3405-13.
2002: J Michael Lord; Aldo Ceriotti; Lynne M Roberts
ER dislocation: Cdc48p/p97 gets into the AAAct.
Current biology : CB 2002;12(5):R182-4.
2002: Elizabeth M Deacon; Trevor R Pettitt; Paul Webb; Timothy Cross; Hema Chahal; Michael J O Wakelam; J Michael Lord
Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.
Journal of cell science 2002;115(Pt 5):983-9.
2002: Philip J Day; Teresa J T Pinheiro; Lynne M Roberts; J Michael Lord
Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer.
Biochemistry 2002;41(8):2836-43.
2002: Dagmar Scheel-Toellner; Keqing Wang; Nico Henriquez; Paul Webb; Rachel Craddock; Darrell Pilling; Arne N Akbar; Mike Salmon; J Michael Lord
Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation.
European journal of immunology 2002;32(2):486-93.
2002: William L Brown; Robert A Mastico; Min Wu; Karen G Heal; Chris J Adams; James B Murray; Jeremy C Simpson; J Michael Lord; Andrew W Taylor-Robinson; Peter G Stockley
RNA bacteriophage capsid-mediated drug delivery and epitope presentation.
Intervirology 2002;45(4-6):371-80.
2001: Alessandra Di Cola; Lorenzo Frigerio; J Michael Lord; Aldo Ceriotti; Lynne M Roberts
Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14726-31.
2001: Stephen K Butcher; Hema Chahal; L Nayak; A Sinclair; Nico Henriquez; E Sapey; D O'Mahony; J Michael Lord
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans.
Journal of leukocyte biology 2001;70(6):881-6.
2001: Lorenzo Frigerio; Nicholas A Jolliffe; Alessandra Di Cola; D H Felipe; Nadine Paris; Jean-Marc Neuhaus; J Michael Lord; Aldo Ceriotti; Lynne M Roberts
The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting.
Plant physiology 2001;126(1):167-75.
2001: Christopher D Buckley; Darrell Pilling; J Michael Lord; Arne N Akbar; Dagmar Scheel-Toellner; Mike Salmon
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation.
Trends in immunology 2001;22(4):199-204.
2001: Philip J Day; S R Owens; Jørgen Wesche; Sjur Olsnes; Lynne M Roberts; J Michael Lord
An interaction between ricin and calreticulin that may have implications for toxin trafficking.
The Journal of biological chemistry 2001;276(10):7202-8.
2000: Paul Webb; Ke-Qing Wang; Dagmar Scheel-Toellner; Judit Pongracz; Mike Salmon; J Michael Lord
Regulation of neutrophil apoptosis: a role for protein kinase C and phosphatidylinositol-3-kinase.
Apoptosis : an international journal on programmed cell death 2000;5(5):451-8.
2000: G Lombardi; Padraic J Dunne; Dagmar Scheel-Toellner; T Sanyal; Darrell Pilling; Leonie S Taams; P Life; J Michael Lord; Mike Salmon; Arne N Akbar
Type 1 IFN maintains the survival of anergic CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3782-9.
2000: Lorenzo Frigerio; J Michael Lord
Glycoprotein degradation: do sugars hold the key?
Current biology : CB 2000;10(18):R674-7.
2000: Christopher D Buckley; Nicole Amft; Paul F Bradfield; Darrell Pilling; E Ross; Fernando Arenzana-Seisdedos; Ali Amara; S John Curnow; J Michael Lord; Dagmar Scheel-Toellner; Mike Salmon
Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3423-9.
2000: John Gordon; Anita Challa; JM Levens; Christopher D Gregory; Julie Williams; Richard J Armitage; Jonathan P Cook; Lynne M Roberts; J Michael Lord
CD40 ligand, Bcl-2, and Bcl-xL spare group I Burkitt lymphoma cells from CD77-directed killing via Verotoxin-1 B chain but fail to protect against the holotoxin.
Cell death and differentiation 2000;7(9):785-94.
2000: L McMillan; S Butcher; Yvonne Wallis; J P Neoptolemos; J Michael Lord
Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis.
Biochemical and biophysical research communications 2000;273(1):45-9.
2000: J Michael Lord; John Davey; Lorenzo Frigerio; Lynne M Roberts
Endoplasmic reticulum-associated protein degradation.
Seminars in cell & developmental biology 2000;11(3):159-64.
2000: T Cross; G Griffiths; Elizabeth M Deacon; R Sallis; Michael Gough; D Watters; J Michael Lord
PKC-delta is an apoptotic lamin kinase.
Oncogene 2000;19(19):2331-7.
2000: T G Cross; Dagmar Scheel-Toellner; Nico Henriquez; E Deacon; Mike Salmon; J Michael Lord
Serine/threonine protein kinases and apoptosis.
Experimental cell research 2000;256(1):34-41.
2000: R H Argent; AM Parrott; Philip J Day; Lynne M Roberts; Peter G Stockley; J Michael Lord; Sheena E Radford
Ribosome-mediated folding of partially unfolded ricin A-chain.
The Journal of biological chemistry 2000;275(13):9263-9.
2000: Dagmar Scheel-Toellner; Arne N Akbar; Darrell Pilling; Catherine H Orteu; Christopher D Buckley; Keqing Wang; Paul Webb; J Michael Lord; Mike Salmon
Type I interferons inhibit the resolution of chronic inflammation.
Symposia of the Society for Experimental Biology 2000;52():277-88.
1999: Judit Pongracz; P Webb; K Wang; Elizabeth M Deacon; O J Lunn; J Michael Lord
Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta.
The Journal of biological chemistry 1999;274(52):37329-34.
1999: Anne Girod; Brian Storrie; JC Simpson; Ludger Johannes; Bruno Goud; Lynne M Roberts; J Michael Lord; T Nilsson; Rainer Pepperkok
Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum.
Nature cell biology 1999;1(7):423-30.
1999: N McCloskey; John D Pound; Michelle J Holder; Julie Williams; Lynne M Roberts; J Michael Lord; John Gordon
The extrafollicular-to-follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40.
European journal of immunology 1999;29(10):3236-44.
1999: DJ Radford; J Michael Lord; Caroline O S Savage
The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation.
Clinical and experimental immunology 1999;118(1):171-9.
1999: JC Simpson; Lynne M Roberts; Karin Römisch; John Davey; D H Wolf; J Michael Lord
Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast.
FEBS letters 1999;459(1):80-4.
1999: Dagmar Scheel-Toellner; Darrell Pilling; Arne N Akbar; D Hardie; G Lombardi; Mike Salmon; J Michael Lord
Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta.
European journal of immunology 1999;29(8):2603-12.
1999: K L Noakes; H T Teisserenc; J Michael Lord; P R Dunbar; Vincenzo Cerundolo; Lynne M Roberts
Exploiting retrograde transport of Shiga-like toxin 1 for the delivery of exogenous antigens into the MHC class I presentation pathway.
FEBS letters 1999;453(1-2):95-9.
1999: N Lea; J Michael Lord; Lynne M Roberts
Proteolytic cleavage of the A subunit is essential for maximal cytotoxicity of Escherichia coli O157:H7 Shiga-like toxin-1.
Microbiology (Reading, England) 1999;145 ( Pt 5)():999-1004.
1999: Nicholas Pumphrey; V Taylor; S Freeman; Michael R Douglas; Paul F Bradfield; Stephen Young; J Michael Lord; Michael J O Wakelam; I N Bird; Mike Salmon; Christopher D Buckley
Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.
FEBS letters 1999;450(1-2):77-83.
1999: Judit Pongracz; J Michael Lord
The lipoxygenase product 13-hydroxyoctadecadienoic acid (13-HODE) is a selective inhibitor of classical PKC isoenzymes.
Biochemical and biophysical research communications 1999;256(2):269-72.
1999: M de Sousa; Lynne M Roberts; J Michael Lord
Restoration of lectin activity to an inactive abrin B chain by substitution and mutation of the 2 gamma subdomain.
European journal of biochemistry / FEBS 1999;260(2):355-61.
1999: Christopher D Buckley; Darrell Pilling; Nico Henriquez; Greg Parsonage; K Threlfall; Dagmar Scheel-Toellner; David L Simmons; Arne N Akbar; J Michael Lord; Mike Salmon
RGD peptides induce apoptosis by direct caspase-3 activation.
Nature 1999;397(6719):534-9.
1999: M E Jackson; JC Simpson; Anne Girod; Rainer Pepperkok; Lynne M Roberts; J Michael Lord
The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum.
Journal of cell science 1999;112 ( Pt 4)():467-75.
1998: Philip J Day; J Michael Lord; Lynne M Roberts
The deoxyribonuclease activity attributed to ribosome-inactivating proteins is due to contamination.
European journal of biochemistry / FEBS 1998;258(2):540-5.
1998: Judit Pongracz; J Michael Lord
Superoxide production in human neutrophils: evidence for signal redundancy and the involvement of more than one PKC isoenzyme class.
Biochemical and biophysical research communications 1998;247(3):624-9.
1998: Lorenzo Frigerio; Alessandro Vitale; J Michael Lord; Aldo Ceriotti; Lynne M Roberts
Free ricin A chain, proricin, and native toxin have different cellular fates when expressed in tobacco protoplasts.
The Journal of biological chemistry 1998;273(23):14194-9.
1998: JC Simpson; Daniel C Smith; Lynne M Roberts; J Michael Lord
Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin.
Experimental cell research 1998;239(2):293-300.
1998: J Michael Lord; Lynne M Roberts
Toxin entry: retrograde transport through the secretory pathway.
The Journal of cell biology 1998;140(4):733-6.
1998: J Michael Lord; Lynne M Roberts
Retrograde transport: going against the flow.
Current biology : CB 1998;8(2):R56-8.
1997: R H Argent; Lynne M Roberts; J Michael Lord
Proteolytic processing of ricin A chain is not required for cytotoxicity.
Biochemical and biophysical research communications 1997;241(3):617-21.
1997: Ian D Sylvester; Lynne M Roberts; J Michael Lord
Characterization of prokaryotic recombinant Aspergillus ribotoxin alpha-sarcin.
Biochimica et biophysica acta 1997;1358(1):53-60.
1997: Trevor R Pettitt; A Martin; T Horton; C Liossis; J Michael Lord; Michael J O Wakelam
Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells.
The Journal of biological chemistry 1997;272(28):17354-9.
1997: Elizabeth M Deacon; J Pongracz; G Griffiths; J Michael Lord
Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.
Molecular pathology : MP 1997;50(3):124-31.
1997: J Zhan; M de Sousa; J A Chaddock; Lynne M Roberts; J Michael Lord
Restoration of lectin activity to a non-glycosylated ricin B chain mutant by the introduction of a novel N-glycosylation site.
FEBS letters 1997;407(3):271-4.
1996: JC Simpson; Lynne M Roberts; J Michael Lord
Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol.
Experimental cell research 1996;229(2):447-51.
1996: J Michael Lord
Go outside and see the proteasome. Protein degradation.
Current biology : CB 1996;6(9):1067-9.
1996: P J Owen; G D Johnson; J Michael Lord
Protein kinase C-delta associates with vimentin intermediate filaments in differentiated HL60 cells.
Experimental cell research 1996;225(2):366-73.
1996: Judit Pongracz; E M Deacon; G D Johnson; D Burnett; J Michael Lord
Doppa induces cell death but not differentiation of U937 cells: evidence for the involvement of PKC-beta 1 in the regulation of apoptosis.
Leukemia research 1996;20(4):319-26.
1996: D Walker; A M Chaddock; J A Chaddock; Lynne M Roberts; J Michael Lord; Colin Robinson
Ricin A chain fused to a chloroplast-targeting signal is unfolded on the chloroplast surface prior to import across the envelope membranes.
The Journal of biological chemistry 1996;271(8):4082-5.
1996: J A Chaddock; Arthur F Monzingo; Jon D Robertus; J Michael Lord; Lynne M Roberts
Major structural differences between pokeweed antiviral protein and ricin A-chain do not account for their differing ribosome specificity.
European journal of biochemistry / FEBS 1996;235(1-2):159-66.
1995: J A Chaddock; Lynne M Roberts; B Jungnickel; J Michael Lord
A hydrophobic region of ricin A chain which may have a role in membrane translocation can function as an efficient noncleaved signal peptide.
Biochemical and biophysical research communications 1995;217(1):68-73.
1995: JC Simpson; Lynne M Roberts; J Michael Lord
Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus.
Protein expression and purification 1995;6(5):665-70.
1995: C Pitcher; L Roberts; S Fawell; Alexey G Zdanovsky; D J FitzGerald; J Michael Lord
Generation of a potent chimeric toxin by replacement of domain III of Pseudomonas exotoxin with ricin A chain KDEL.
Bioconjugate chemistry 1995;6(5):624-9.
1995: N Sphyris; J Michael Lord; R Wales; Lynne M Roberts
Mutational analysis of the Ricinus lectin B-chains. Galactose-binding ability of the 2 gamma subdomain of Ricinus communis agglutinin B-chain.
The Journal of biological chemistry 1995;270(35):20292-7.
1995: JC Simpson; J Michael Lord; Lynne M Roberts
Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation.
European journal of biochemistry / FEBS 1995;232(2):458-63.
1995: JC Simpson; C Dascher; Lynne M Roberts; J Michael Lord; William E Balch
Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.
The Journal of biological chemistry 1995;270(34):20078-83.
1995: Judit Pongracz; W Tuffley; G D Johnson; E M Deacon; D Burnett; R A Stockley; J Michael Lord
Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells.
Experimental cell research 1995;218(2):430-8.
1995: J Michael Lord; Judit Pongracz
Protein kinase C: a family of isoenzymes with distinct roles in pathogenesis.
Clinical molecular pathology 1995;48(2):M57-64.
1995: Judit Pongracz; P Clark; John P Neoptolemos; J Michael Lord
Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids.
International journal of cancer. Journal international du cancer 1995;61(1):35-9.
1995: R H Argent; Lynne M Roberts; J Michael Lord
Purification of recombinant ricin A chain after reassociation with ricin B chain.
Analytical biochemistry 1995;224(1):459-60.
1994: R H Argent; Lynne M Roberts; R Wales; Jon D Robertus; J Michael Lord
Introduction of a disulfide bond into ricin A chain decreases the cytotoxicity of the ricin holotoxin.
The Journal of biological chemistry 1994;269(43):26705-10.
1994: R Wales; H C Gorham; K Hussain; Lynne M Roberts; J Michael Lord
Ricin B chain fragments expressed in Escherichia coli are able to bind free galactose in contrast to the full length polypeptide.
Glycoconjugate journal 1994;11(4):274-81.
1994: Judit Pongracz; G D Johnson; J Crocker; D Burnett; J Michael Lord
The role of protein kinase C in myeloid cell apoptosis.
Biochemical Society transactions 1994;22(3):593-7.
1994: S Taylor; A Massiah; G Lomonossoff; Lynne M Roberts; J Michael Lord; M Hartley
Correlation between the activities of five ribosome-inactivating proteins in depurination of tobacco ribosomes and inhibition of tobacco mosaic virus infection.
The Plant journal : for cell and molecular biology 1994;5(6):827-35.
1994: J A Chaddock; J Michael Lord; M R Hartley; Lynne M Roberts
Pokeweed antiviral protein (PAP) mutations which permit E.coli growth do not eliminate catalytic activity towards prokaryotic ribosomes.
Nucleic acids research 1994;22(9):1536-40.
1994: Sundaram Ramasamy; Michael C Sheppard; F J Evans; J Michael Lord
Phorbol esters showing selective activation of PKC isozymes in vitro regulate thyroid function and insulin-like growth factor binding protein secretion.
Cellular signalling 1994;6(4):439-48.
1994: J Michael Lord; Lynne M Roberts; Jon D Robertus
Ricin: structure, mode of action, and some current applications.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(2):201-8.
1993: R Wales; Lynne M Roberts; J Michael Lord
Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.
The Journal of biological chemistry 1993;268(32):23986-90.
1993: J P Cook; P M Savage; J Michael Lord; Lynne M Roberts
Biologically active interleukin 2-ricin A chain fusion proteins may require intracellular proteolytic cleavage to exhibit a cytotoxic effect.
Bioconjugate chemistry 1993;4(6):440-7.
1993: G Legname; G Gromo; J Michael Lord; N Monzini; Daniela Modena
Expression and activity of pre-dianthin 30 and dianthin 30.
Biochemical and biophysical research communications 1993;192(3):1230-7.
1992: J Michael Lord; R Wales; C Pitcher; Lynne M Roberts
Cell surface and intracellular functions for galactose binding in ricin cytotoxicity.
Biochemical Society transactions 1992;20(4):734-8.
1992: R Wales; J A Chaddock; Lynne M Roberts; J Michael Lord
Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin.
Experimental cell research 1992;203(1):1-4.
1992: M Westby; R H Argent; C Pitcher; J Michael Lord; Lynne M Roberts
Preparation and characterization of recombinant proricin containing an alternative protease-sensitive linker sequence.
Bioconjugate chemistry 1992;3(5):375-81.
1992: Lynne M Roberts; J Michael Lord
Cytotoxic proteins.
Current opinion in biotechnology 1992;3(4):422-9.
1992: Dianne L Newton; R Wales; P T Richardson; Stuart Walbridge; S K Saxena; E J Ackerman; Lynne M Roberts; J Michael Lord; Richard J Youle
Cell surface and intracellular functions for ricin galactose binding.
The Journal of biological chemistry 1992;267(17):11917-22.
1992: R Wales; P T Richardson; Lynne M Roberts; J Michael Lord
Recombinant ricin B chain fragments containing a single galactose binding site retain lectin activity.
Archives of biochemistry and biophysics 1992;294(1):291-6.
1992: M O'Hare; Lynne M Roberts; J Michael Lord
Biological activity of recombinant Ricinus communis agglutinin A chain produced in Escherichia coli.
FEBS letters 1992;299(3):209-12.
1992: Lynne M Roberts; J W Tregear; J Michael Lord
Molecular cloning of ricin.
Targeted diagnosis and therapy 1992;7():81-97.
1992: J Michael Lord; Lynne M Roberts; Philip E Thorpe
Chimeric proteins containing ricin A chain.
Targeted diagnosis and therapy 1992;7():183-90.
1992: N A Jones; J Michael Lord; Geoffrey Brown
Changes in the phosphorylation status of a 19 kD cytosolic protein are linked to the growth arrest of HL-60 cells.
Leukemia research 1992;16(4):353-61.
1991: J H Gould; M R Hartley; P C Welsh; D K Hoshizaki; A Frankel; Lynne M Roberts; J Michael Lord
Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes.
Molecular & general genetics : MGG 1991;230(1-2):81-90.
1991: R Wales; P T Richardson; Lynne M Roberts; Hugh R Woodland; J Michael Lord
Mutational analysis of the galactose binding ability of recombinant ricin B chain.
The Journal of biological chemistry 1991;266(29):19172-9.
1991: M R Hartley; G Legname; R Osborn; Z Chen; J Michael Lord
Single-chain ribosome inactivating proteins from plants depurinate Escherichia coli 23S ribosomal RNA.
FEBS letters 1991;290(1-2):65-8.
1991: P J French; Christopher M Bunce; Len R Stephens; J Michael Lord; F M McConnell; Geoffrey Brown; J A Creba; Robert H Michell
Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes.
Proceedings. Biological sciences / The Royal Society 1991;245(1314):193-201.
1991: G Legname; P Bellosta; G Gromo; Daniela Modena; J N Keen; Lynne M Roberts; J Michael Lord
Nucleotide sequence of cDNA coding for dianthin 30, a ribosome inactivating protein from Dianthus caryophyllus.
Biochimica et biophysica acta 1991;1090(1):119-22.
1991: P T Richardson; K Hussain; Hugh R Woodland; J Michael Lord; Lynne M Roberts
The effects of N-glycosylation on the lectin activity of recombinant ricin B chain.
Carbohydrate research 1991;213():19-25.
1991: K A Wood; J Michael Lord; E J Wawrzynczak; M Piatak
Preproabrin: genomic cloning, characterisation and the expression of the A-chain in Escherichia coli.
European journal of biochemistry / FEBS 1991;198(3):723-32.
1991: M A Baxter; G Grafton; Christopher M Bunce; J Michael Lord; Robert H Michell; Geoffrey Brown
The role of inositol transport in cellular differentiation.
Biochemical Society transactions 1991;19(2):86S.
1991: J Michael Lord; Christopher M Bunce; P J French; N A Jones; M A Baxter; G Grafton; Robert H Michell; Geoffrey Brown
Protein phosphorylation events and changes in inositol metabolism during HL60 cell differentiation.
Biochemical Society transactions 1991;19(2):315-20.
1991: J Michael Lord; M R Hartley; Lynne M Roberts
Ribosome inactivating proteins of plants.
Seminars in cell biology 1991;2(1):15-22.
1991: M A Baxter; Christopher M Bunce; J Michael Lord; P J French; Robert H Michell; Geoffrey Brown
Changes in inositol transport during DMSO-induced differentiation of HL60 cells towards neutrophils.
Biochimica et biophysica acta 1991;1091(2):158-64.
1990: M O'Hare; A N Brown; K Hussain; A Gebhardt; G Watson; Lynne M Roberts; E S Vitetta; Philip E Thorpe; J Michael Lord
Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically-cleavable spacer sequence.
FEBS letters 1990;273(1-2):200-4.
1990: S D Irwin; J Michael Lord
Nucleotide sequence of a Ricinus communis 2S albumin precursor gene.
Nucleic acids research 1990;18(19):5890.
1990: S D Irwin; J N Keen; J B Findlay; J Michael Lord
The Ricinus communis 2S albumin precursor: a single preproprotein may be processed into two different heterodimeric storage proteins.
Molecular & general genetics : MGG 1990;222(2-3):400-8.
1990: Robert H Michell; L A Conroy; M Finney; P J French; Geoffrey Brown; J A Creba; Christopher M Bunce; J Michael Lord
Inositol lipids and phosphates in the regulation of the growth and differentiation of haemopoietic and other cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):193-207.
1990: Christopher M Bunce; W N Patton; John D Pound; J Michael Lord; Geoffrey Brown
Phorbol myristate acetate treatment of normal human myeloid blast cells promotes monopoiesis and inhibits granulopoiesis.
Leukemia research 1990;14(11-12):1007-17.
1990: Geoffrey Brown; Christopher M Bunce; J Michael Lord
Models of haemopoiesis.
Leukemia research 1990;14(6):495-9.
1990: Robert H Michell; L A Conroy; P J French; Christopher M Bunce; J Michael Lord; Geoffrey Brown; M A Baxter; F McConnell; J A Creba
Inositol lipids and phosphates in the differentiation of blood cells.
Advances in second messenger and phosphoprotein research 1990;24():147-51.
1989: P T Richardson; M Westby; Lynne M Roberts; J H Gould; A Colman; J Michael Lord
Recombinant proricin binds galactose but does not depurinate 28 S ribosomal RNA.
FEBS letters 1989;255(1):15-20.
1989: K Hussain; C Bowler; Lynne M Roberts; J Michael Lord
Expression of ricin B chain in Escherichia coli.
FEBS letters 1989;244(2):383-7.
1989: J Michael Lord; Robert Spooner; Lynne M Roberts
Immunotoxins: monoclonal antibody-toxin conjugates--a new approach to cancer therapy.
Advances in biotechnological processes 1989;11():193-211.
1989: M J May; M R Hartley; Lynne M Roberts; P A Krieg; R W Osborn; J Michael Lord
Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild-type and mutant polypeptides.
The EMBO journal 1989;8(1):301-8.
1988: Geoffrey Brown; Christopher M Bunce; J Michael Lord; F M McConnell
The development of cell lineages: a sequential model.
Differentiation; research in biological diversity 1988;39(2):83-9.
1988: Christopher M Bunce; J A Thick; J Michael Lord; D Mills; Geoffrey Brown
A rapid procedure for isolating hemopoietic cell nuclei.
Analytical biochemistry 1988;175(1):67-73.
1988: J Michael Lord; Christopher M Bunce; R J Duncan; I D Phillips; Kathleen I J Shennan; Kevin Docherty; Geoffrey Brown
Changes in insulin receptor expression in HL60 cells induced to differentiate towards neutrophils or monocytes.
Journal of molecular endocrinology 1988;1(3):197-201.
1988: J Michael Lord; C Halpin
Formation of protein bodies and glyoxysomes.
Biochemical Society transactions 1988;16(5):706-8.
1988: P T Richardson; Lynne M Roberts; J H Gould; J Michael Lord
The expression of functional ricin B-chain in Saccharomyces cerevisiae.
Biochimica et biophysica acta 1988;950(3):385-94.
1988: J Michael Lord; J A Thick; Christopher M Bunce; A Malcolm R Taylor; P H Gallimore; D Mills; Geoffrey Brown
Characterization of a novel nuclear envelope protein restricted to certain cell types.
Journal of cell science 1988;90 ( Pt 2)():237-45.
1987: J Michael Lord; Lynne M Roberts
Plant toxins.
Microbiological sciences 1987;4(12):376-8.
1987: J Michael Lord
The use of cytotoxic plant lectins in cancer therapy.
Plant physiology 1987;85(1):1-3.
1987: M O'Hare; Lynne M Roberts; Philip E Thorpe; G J Watson; B Prior; J Michael Lord
Expression of ricin A chain in Escherichia coli.
FEBS letters 1987;216(1):73-8.
1987: J Michael Lord; J Gould; D Griffiths; M O'Hare; B Prior; P T Richardson; Lynne M Roberts
Ricin: cytotoxicity, biosynthesis and use in immunoconjugates.
Progress in medicinal chemistry 1987;24():1-28.
1983: M J Conder; J Michael Lord
Heterogeneous distribution of glycosyltransferases in the endoplasmic reticulum of castor bean endosperm.
Plant physiology 1983;72(2):547-52.