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Michael Lord

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
86
Roberts, Lynne
22
Salmon, Mike
20
Scheel-Toellner, Dagmar
16
Smith, Daniel
13
Brown, Geoffrey
13
Bunce, Christopher
11
Akbar, Arne
11
Buckley, Christopher
10
Frigerio, Lorenzo
9
Ceriotti, Aldo
9
Pilling, Darrell
8
Pongracz, Judit
8
Marsden, Catherine
8
Simpson, JC
7
Johannes, Ludger

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Publications

TOP 3
Wong S H; Francis N; Chahal H; Raza K; Salmon M; Scheel-Toellner D; Lord J M
Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid.
Spooner Robert A; Hart Philip J; Cook Jonathan P; Pietroni Paola; Rogon Christian; Höhfeld Jörg; Roberts Lynne M; Lord J Michael
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum.
Chamberlain Kerry L; Marshall Richard S; Jolliffe Nicholas A; Frigerio Lorenzo; Ceriotti Aldo; Lord J Michael; Roberts Lynne M
Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism.

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All Publications

2009: Wong S H; Francis N; Chahal H; Raza K; Salmon M; Scheel-Toellner D; Lord J M
Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid.
Rheumatology (Oxford, England) 2009;48(1):39-44.
2008: Spooner Robert A; Hart Philip J; Cook Jonathan P; Pietroni Paola; Rogon Christian; Höhfeld Jörg; Roberts Lynne M; Lord J Michael
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17408-13.
2008: Chamberlain Kerry L; Marshall Richard S; Jolliffe Nicholas A; Frigerio Lorenzo; Ceriotti Aldo; Lord J Michael; Roberts Lynne M
Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism.
The Journal of biological chemistry 2008;283(48):33276-86.
2008: Spooner Robert A; Watson Peter; Smith Daniel C; Boal Frédéric; Amessou Mohammed; Johannes Ludger; Clarkson Guy J; Lord J Michael; Stephens David J; Roberts Lynne M
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.
The Biochemical journal 2008;414(3):471-84.
2008: Marshall Richard S; Jolliffe Nicholas A; Ceriotti Aldo; Snowden Christopher J; Lord J Michael; Frigerio Lorenzo; Roberts Lynne M
The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells.
The Journal of biological chemistry 2008;283(23):15869-77.
2008: Scheel-Toellner Dagmar; Raza Karim; Assi Lakhvir; Pilling Darrell; Ross Emma J; Lee Wing Yiu; Curnow S John; Buckley Christopher D; Akbar Arne N; Lord Janet M; Salmon Mike
Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.
Apoptosis : an international journal on programmed cell death 2008;13(1):109-17.
2007: Allen Stuart C H; Moore Katherine A H; Marsden Catherine J; Fülöp Vilmos; Moffat Kevin G; Lord J Michael; Ladds Graham; Roberts Lynne M
The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae.
The FEBS journal 2007;274(21):5586-99.
2007: Assi Lakhvir K; Wong See Heng; Ludwig Andreas; Raza Karim; Gordon Caroline; Salmon Michael; Lord Janet M; Scheel-Toellner Dagmar
Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint.
Arthritis and rheumatism 2007;56(6):1776-86.
2007: Amessou Mohamed; Fradagrada Alexandre; Falguières Thomas; Lord J Michael; Smith Daniel C; Roberts Lynne M; Lamaze Christophe; Johannes Ludger
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins.
Journal of cell science 2007;120(Pt 8):1457-68.
2007: Jarvis Rosemary M; Chamba Anita; Holder Michelle J; Challa Anita; Smith Daniel C; Hodgkin Matthew N; Lord J Michael; Gordon John
Dynamic interplay between the neutral glycosphingolipid CD77/Gb3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells.
Biochemical and biophysical research communications 2007;355(4):944-9.
2007: Phillips Anna C; Burns Victoria E; Lord Janet M
Stress and exercise: Getting the balance right for aging immunity.
Exercise and sport sciences reviews 2007;35(1):35-9.
2007: Raza Karim; Scheel-Toellner Dagmar; Lord Janet M; Akbar Arne N; Buckley Christopher D; Salmon Mike
The assessment of T-cell apoptosis in synovial fluid.
Methods in molecular medicine 2007;136():117-38.
2006: Jolliffe Nicholas A; Di Cola Alessandra; Marsden Catherine J; Lord J Michael; Ceriotti Aldo; Frigerio Lorenzo; Roberts Lynne M
The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts.
The Journal of biological chemistry 2006;281(33):23377-85.
2006: Arlt Wiebke; Hammer Fabian; Sanning Petra; Butcher Stephen K; Lord Janet M; Allolio Bruno; Annane Djillali; Stewart Paul M
Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.
The Journal of clinical endocrinology and metabolism 2006;91(7):2548-54.
2006: Smith Daniel C; Spooner Robert A; Watson Peter D; Murray James L; Hodge Thomas W; Amessou Mohamed; Johannes Ludger; Lord J Michael; Roberts Lynne M
Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum.
Traffic (Copenhagen, Denmark) 2006;7(4):379-93.
2006: McGettrick Helen M; Lord Janet M; Wang Ke-Qing; Rainger G Ed; Buckley Christopher D; Nash Gerard B
Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium.
Journal of leukocyte biology 2006;79(4):779-88.
2006: Smith Daniel C; Sillence Daniel J; Falguières Thomas; Jarvis Rosemary M; Johannes Ludger; Lord J Michael; Platt Frances M; Roberts Lynne M
The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.
Molecular biology of the cell 2006;17(3):1375-87.
2006: Ross Ewan A; Douglas Mike R; Wong See Heng; Ross Emma J; Curnow S John; Nash Gerard B; Rainger Ed; Scheel-Toellner Dagmar; Lord Janet M; Salmon Mike; Buckley Christopher D
Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis.
Blood 2006;107(3):1178-83.
2006: Raza Karim; Scheel-Toellner Dagmar; Lee Chi-Yeung; Pilling Darrell; Curnow S John; Falciani Francesco; Trevino Victor; Kumar Kanta; Assi Lakhvir K; Lord Janet M; Gordon Caroline; Buckley Christopher D; Salmon Mike
Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis.
Arthritis research & therapy 2006;8(4):R120.
2006: Spooner Robert A; Smith Daniel C; Easton Andrew J; Roberts Lynne M; Lord J Michael
Retrograde transport pathways utilised by viruses and protein toxins.
Virology journal 2006;3():26.
2005: Allen Stuart C H; Byron Adam; Lord J Michael; Davey John; Roberts Lynne M; Ladds Graham
Utilisation of the budding yeast Saccharomyces cerevisiae for the generation and isolation of non-lethal ricin A chain variants.
Yeast (Chichester, England) 2005;22(16):1287-97.
2005: Lord J Michael; Roberts Lynne M; Stirling Colin J
Quality control: another player joins the ERAD cast.
Current biology : CB 2005;15(23):R963-4.
2005: Butcher Stephen K; Killampalli Vijay; Lascelles David; Wang Keqing; Alpar E Kaya; Lord Janet M
Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity.
Aging cell 2005;4(6):319-24.
2005: Vago Riccardo; Marsden Catherine J; Lord J Michael; Ippoliti Rodolfo; Flavell David J; Flavell Sopsamorn-U; Ceriotti Aldo; Fabbrini M Serena
Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.
The FEBS journal 2005;272(19):4983-95.
2005: Hampson Peter; Chahal Hema; Khanim Farhat; Hayden Rachel; Mulder Anneke; Assi Lakhvir Kaur; Bunce Christopher M; Lord Janet M
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Blood 2005;106(4):1362-8.
2005: Marsden Catherine J; Smith Daniel C; Roberts Lynne M; Lord J Michael
Ricin: current understanding and prospects for an antiricin vaccine.
Expert review of vaccines 2005;4(2):229-37.
2005: Lord J Michael; High Stephen
Polytopic proteins: preventing aggregation in the membrane.
Current biology : CB 2005;15(5):R169-71.
2005: Di Cola Alessandra; Frigerio Lorenzo; Lord J Michael; Roberts Lynne M; Ceriotti Aldo
Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features.
Plant physiology 2005;137(1):287-96.
2005: Lord J M; Roberts L M; Lencer W I
Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation.
Current topics in microbiology and immunology 2005;300():149-68.
2005: Raza Karim; Falciani Francesco; Curnow S John; Ross Emma J; Lee Chi-Yeung; Akbar Arne N; Lord Janet M; Gordon Caroline; Buckley Christopher D; Salmon Mike
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.
Arthritis research & therapy 2005;7(4):R784-95.
2004: Scheel-Toellner D; Wang K; Assi L K; Webb P R; Craddock R M; Salmon M; Lord J M
Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis.
Biochemical Society transactions 2004;32(Pt 5):679-81.
2004: Scheel-Toellner Dagmar; Wang Keqing; Craddock Rachel; Webb Paul R; McGettrick Helen M; Assi Lakhvir Kaur; Parkes Neal; Clough Louise E; Gulbins Erich; Salmon Mike; Lord Janet M
Reactive oxygen species limit neutrophil life span by activating death receptor signaling.
Blood 2004;104(8):2557-64.
2004: Spooner Robert A; Watson Peter D; Marsden Catherine J; Smith Daniel C; Moore Katherine A H; Cook Jonathon P; Lord J Michael; Roberts Lynne M
Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum.
The Biochemical journal 2004;383(Pt 2):285-93.
2004: Hartley M R; Lord J M
Cytotoxic ribosome-inactivating lectins from plants.
Biochimica et biophysica acta 2004;1701(1-2):1-14.
2004: Butcher Stephen K; Lord Janet M
Stress responses and innate immunity: aging as a contributory factor.
Aging cell 2004;3(4):151-60.
2004: Smith Daniel C; Salio Mariolina; Lord J Michael; Roberts Lynne M; Cerundolo Vincenzo
Lack of dendritic cell maturation by the plant toxin ricin.
European journal of immunology 2004;34(8):2149-57.
2004: Smith Daniel C; Lord J Michael; Roberts Lynne M; Johannes Ludger
Glycosphingolipids as toxin receptors.
Seminars in cell & developmental biology 2004;15(4):397-408.
2004: Marsden Catherine J; Knight Simon; Smith Daniel C; Day Philip J; Roberts Lynne M; Phillips Gary J; Lord J Michael
Insertional mutagenesis of ricin A chain: a novel route to an anti-ricin vaccine.
Vaccine 2004;22(21-22):2800-5.
2004: Roberts Lynne M; Lord J Michael
Ribosome-inactivating proteins: entry into mammalian cells and intracellular routing.
Mini reviews in medicinal chemistry 2004;4(5):505-12.
2004: Hartley Martin R; Lord J Michael
Genetics of ribosome-inactivating proteins.
Mini reviews in medicinal chemistry 2004;4(5):487-92.
2004: Scheel-Toellner D; Wang K-Q; Webb P R; Wong S H; Craddock R; Assi L K; Salmon M; Lord J M
Early events in spontaneous neutrophil apoptosis.
Biochemical Society transactions 2004;32(Pt3):461-4.
2004: Marsden Catherine J; Fülöp Vilmos; Day Philip J; Lord J Michael
The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain.
European journal of biochemistry / FEBS 2004;271(1):153-62.
2003: Lord J M; Deeks E; Marsden C J; Moore K; Pateman C; Smith D C; Spooner R A; Watson P; Roberts L M
Retrograde transport of toxins across the endoplasmic reticulum membrane.
Biochemical Society transactions 2003;31(Pt 6):1260-2.
2003: Lord Janet M
A physiological role for alpha2-HS glycoprotein: stimulation of macrophage uptake of apoptotic cells.
Clinical science (London, England : 1979) 2003;105(3):267-8.
2003: Wang KeQing; Scheel-Toellner Dagmar; Wong See Heng; Craddock Rachel; Caamano Jorge; Akbar Arne N; Salmon Mike; Lord Janet M
Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):1035-41.
2003: Butcher S K; Killampalli V; Chahal H; Kaya Alpar E; Lord J M
Effect of age on susceptibility to post-traumatic infection in the elderly.
Biochemical Society transactions 2003;31(2):449-51.
2002: Lord J Michael; Frigerio Lorenzo
ER quality control: a function for sugars in the cytosol.
Current biology : CB 2002;12(19):R663-5.
2002: Scheel-Toellner D; Wang K; Singh R; Majeed S; Raza K; Curnow S J; Salmon M; Lord J M
The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis.
Biochemical and biophysical research communications 2002;297(4):876-9.
2002: Smith Daniel C; Lord J Michael; Roberts Lynne M; Tartour Eric; Johannes Ludger
1st class ticket to class I: protein toxins as pathfinders for antigen presentation.
Traffic (Copenhagen, Denmark) 2002;3(10):697-704.
2002: Smith Daniel C; Gallimore Awen; Jones Emma; Roberts Brenda; Lord J Michael; Deeks Emma; Cerundolo Vincenzo; Roberts Lynne M
Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):99-107.
2002: Lord Janet M; Akbar Arne N; Kipling David
Telomere-based therapy for immunosenescence.
Trends in immunology 2002;23(4):175-6.
2002: Lord J Michael; Ceriotti Aldo; Roberts Lynne M
ER dislocation: Cdc48p/p97 gets into the AAAct.
Current biology : CB 2002;12(5):R182-4.
2002: Deeks Emma D; Cook Jonathan P; Day Philip J; Smith Daniel C; Roberts Lynne M; Lord J Michael
The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol.
Biochemistry 2002;41(10):3405-13.
2002: Deacon Elizabeth M; Pettitt Trevor R; Webb Paul; Cross Timothy; Chahal Hema; Wakelam Michael J O; Lord Janet M
Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.
Journal of cell science 2002;115(Pt 5):983-9.
2002: Day Philip J; Pinheiro Teresa J T; Roberts Lynne M; Lord J Michael
Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer.
Biochemistry 2002;41(8):2836-43.
2002: Scheel-Toellner Dagmar; Wang Keqing; Henriquez Nico V; Webb Paul R; Craddock Rachel; Pilling Darrell; Akbar Arne N; Salmon Mike; Lord Janet M
Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation.
European journal of immunology 2002;32(2):486-93.
2002: Brown William L; Mastico Robert A; Wu Min; Heal Karen G; Adams Chris J; Murray James B; Simpson Jeremy C; Lord J Michael; Taylor-Robinson Andrew W; Stockley Peter G
RNA bacteriophage capsid-mediated drug delivery and epitope presentation.
Intervirology 2002;45(4-6):371-80.
2001: Butcher S K; Chahal H; Nayak L; Sinclair A; Henriquez N V; Sapey E; O'Mahony D; Lord J M
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans.
Journal of leukocyte biology 2001;70(6):881-6.
2001: Di Cola A; Frigerio L; Lord J M; Ceriotti A; Roberts L M
Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14726-31.
2001: Frigerio L; Jolliffe N A; Di Cola A; Felipe D H; Paris N; Neuhaus J M; Lord J M; Ceriotti A; Roberts L M
The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting.
Plant physiology 2001;126(1):167-75.
2001: Buckley C D; Pilling D; Lord J M; Akbar A N; Scheel-Toellner D; Salmon M
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation.
Trends in immunology 2001;22(4):199-204.
2001: Day P J; Owens S R; Wesche J; Olsnes S; Roberts L M; Lord J M
An interaction between ricin and calreticulin that may have implications for toxin trafficking.
The Journal of biological chemistry 2001;276(10):7202-8.
2000: Webb P R; Wang K Q; Scheel-Toellner D; Pongracz J; Salmon M; Lord J M
Regulation of neutrophil apoptosis: a role for protein kinase C and phosphatidylinositol-3-kinase.
Apoptosis : an international journal on programmed cell death 2000;5(5):451-8.
2000: Lombardi G; Dunne P J; Scheel-Toellner D; Sanyal T; Pilling D; Taams L S; Life P; Lord J M; Salmon M; Akbar A N
Type 1 IFN maintains the survival of anergic CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3782-9.
2000: Gordon J; Challa A; Levens J M; Gregory C D; Williams J M; Armitage R J; Cook J P; Roberts L M; Lord J M
CD40 ligand, Bcl-2, and Bcl-xL spare group I Burkitt lymphoma cells from CD77-directed killing via Verotoxin-1 B chain but fail to protect against the holotoxin.
Cell death and differentiation 2000;7(9):785-94.
2000: Frigerio L; Lord J M
Glycoprotein degradation: do sugars hold the key?
Current biology : CB 2000;10(18):R674-7.
2000: Buckley C D; Amft N; Bradfield P F; Pilling D; Ross E; Arenzana-Seisdedos F; Amara A; Curnow S J; Lord J M; Scheel-Toellner D; Salmon M
Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3423-9.
2000: Lord J M; Davey J; Frigerio L; Roberts L M
Endoplasmic reticulum-associated protein degradation.
Seminars in cell & developmental biology 2000;11(3):159-64.
2000: McMillan L; Butcher S; Wallis Y; Neoptolemos J P; Lord J M
Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis.
Biochemical and biophysical research communications 2000;273(1):45-9.
2000: Cross T; Griffiths G; Deacon E; Sallis R; Gough M; Watters D; Lord J M
PKC-delta is an apoptotic lamin kinase.
Oncogene 2000;19(19):2331-7.
2000: Cross T G; Scheel-Toellner D; Henriquez N V; Deacon E; Salmon M; Lord J M
Serine/threonine protein kinases and apoptosis.
Experimental cell research 2000;256(1):34-41.
2000: Argent R H; Parrott A M; Day P J; Roberts L M; Stockley P G; Lord J M; Radford S E
Ribosome-mediated folding of partially unfolded ricin A-chain.
The Journal of biological chemistry 2000;275(13):9263-9.
2000: Scheel-Toellner D; Akbar A N; Pilling D; Orteu C H; Buckley C D; Wang K; Webb P R; Lord J M; Salmon M
Type I interferons inhibit the resolution of chronic inflammation.
Symposia of the Society for Experimental Biology 2000;52():277-88.
1999: Pongracz J; Webb P; Wang K; Deacon E; Lunn O J; Lord J M
Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta.
The Journal of biological chemistry 1999;274(52):37329-34.
1999: Girod A; Storrie B; Simpson J C; Johannes L; Goud B; Roberts L M; Lord J M; Nilsson T; Pepperkok R
Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum.
Nature cell biology 1999;1(7):423-30.
1999: McCloskey N; Pound J D; Holder M J; Williams J M; Roberts L M; Lord J M; Gordon J
The extrafollicular-to-follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40.
European journal of immunology 1999;29(10):3236-44.
1999: Radford D J; Lord J M; Savage C O
The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation.
Clinical and experimental immunology 1999;118(1):171-9.
1999: Simpson J C; Roberts L M; Römisch K; Davey J; Wolf D H; Lord J M
Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast.
FEBS letters 1999;459(1):80-4.
1999: Scheel-Toellner D; Pilling D; Akbar A N; Hardie D; Lombardi G; Salmon M; Lord J M
Inhibition of T cell apoptosis by IFN-beta rapidly reverses nuclear translocation of protein kinase C-delta.
European journal of immunology 1999;29(8):2603-12.
1999: Noakes K L; Teisserenc H T; Lord J M; Dunbar P R; Cerundolo V; Roberts L M
Exploiting retrograde transport of Shiga-like toxin 1 for the delivery of exogenous antigens into the MHC class I presentation pathway.
FEBS letters 1999;453(1-2):95-9.
1999: Lea N; Lord J M; Roberts L M
Proteolytic cleavage of the A subunit is essential for maximal cytotoxicity of Escherichia coli O157:H7 Shiga-like toxin-1.
Microbiology (Reading, England) 1999;145 ( Pt 5)():999-1004.
1999: Pumphrey N J; Taylor V; Freeman S; Douglas M R; Bradfield P F; Young S P; Lord J M; Wakelam M J; Bird I N; Salmon M; Buckley C D
Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.
FEBS letters 1999;450(1-2):77-83.
1999: de Sousa M; Roberts L M; Lord J M
Restoration of lectin activity to an inactive abrin B chain by substitution and mutation of the 2 gamma subdomain.
European journal of biochemistry / FEBS 1999;260(2):355-61.
1999: Pongracz J; Lord J M
The lipoxygenase product 13-hydroxyoctadecadienoic acid (13-HODE) is a selective inhibitor of classical PKC isoenzymes.
Biochemical and biophysical research communications 1999;256(2):269-72.
1999: Buckley C D; Pilling D; Henriquez N V; Parsonage G; Threlfall K; Scheel-Toellner D; Simmons D L; Akbar A N; Lord J M; Salmon M
RGD peptides induce apoptosis by direct caspase-3 activation.
Nature 1999;397(6719):534-9.
1999: Jackson M E; Simpson J C; Girod A; Pepperkok R; Roberts L M; Lord J M
The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum.
Journal of cell science 1999;112 ( Pt 4)():467-75.
1998: Day P J; Lord J M; Roberts L M
The deoxyribonuclease activity attributed to ribosome-inactivating proteins is due to contamination.
European journal of biochemistry / FEBS 1998;258(2):540-5.
1998: Pongracz J; Lord J M
Superoxide production in human neutrophils: evidence for signal redundancy and the involvement of more than one PKC isoenzyme class.
Biochemical and biophysical research communications 1998;247(3):624-9.
1998: Frigerio L; Vitale A; Lord J M; Ceriotti A; Roberts L M
Free ricin A chain, proricin, and native toxin have different cellular fates when expressed in tobacco protoplasts.
The Journal of biological chemistry 1998;273(23):14194-9.
1998: Simpson J C; Smith D C; Roberts L M; Lord J M
Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin.
Experimental cell research 1998;239(2):293-300.
1998: Lord J M; Roberts L M
Toxin entry: retrograde transport through the secretory pathway.
The Journal of cell biology 1998;140(4):733-6.
1998: Lord J M; Roberts L M
Retrograde transport: going against the flow.
Current biology : CB 1998;8(2):R56-8.
1997: Argent R H; Roberts L M; Lord J M
Proteolytic processing of ricin A chain is not required for cytotoxicity.
Biochemical and biophysical research communications 1997;241(3):617-21.
1997: Sylvester I D; Roberts L M; Lord J M
Characterization of prokaryotic recombinant Aspergillus ribotoxin alpha-sarcin.
Biochimica et biophysica acta 1997;1358(1):53-60.
1997: Pettitt T R; Martin A; Horton T; Liossis C; Lord J M; Wakelam M J
Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells.
The Journal of biological chemistry 1997;272(28):17354-9.
1997: Deacon E M; Pongracz J; Griffiths G; Lord J M
Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.
Molecular pathology : MP 1997;50(3):124-31.
1997: Zhan J; de Sousa M; Chaddock J A; Roberts L M; Lord J M
Restoration of lectin activity to a non-glycosylated ricin B chain mutant by the introduction of a novel N-glycosylation site.
FEBS letters 1997;407(3):271-4.
1996: Simpson J C; Roberts L M; Lord J M
Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol.
Experimental cell research 1996;229(2):447-51.
1996: Lord J M
Go outside and see the proteasome. Protein degradation.
Current biology : CB 1996;6(9):1067-9.
1996: Owen P J; Johnson G D; Lord J M
Protein kinase C-delta associates with vimentin intermediate filaments in differentiated HL60 cells.
Experimental cell research 1996;225(2):366-73.
1996: Pongracz J; Deacon E M; Johnson G D; Burnett D; Lord J M
Doppa induces cell death but not differentiation of U937 cells: evidence for the involvement of PKC-beta 1 in the regulation of apoptosis.
Leukemia research 1996;20(4):319-26.
1996: Walker D; Chaddock A M; Chaddock J A; Roberts L M; Lord J M; Robinson C
Ricin A chain fused to a chloroplast-targeting signal is unfolded on the chloroplast surface prior to import across the envelope membranes.
The Journal of biological chemistry 1996;271(8):4082-5.
1996: Chaddock J A; Monzingo A F; Robertus J D; Lord J M; Roberts L M
Major structural differences between pokeweed antiviral protein and ricin A-chain do not account for their differing ribosome specificity.
European journal of biochemistry / FEBS 1996;235(1-2):159-66.
1995: Chaddock J A; Roberts L M; Jungnickel B; Lord J M
A hydrophobic region of ricin A chain which may have a role in membrane translocation can function as an efficient noncleaved signal peptide.
Biochemical and biophysical research communications 1995;217(1):68-73.
1995: Simpson J C; Roberts L M; Lord J M
Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus.
Protein expression and purification 1995;6(5):665-70.
1995: Pitcher C; Roberts L; Fawell S; Zdanovsky A G; FitzGerald D J; Lord J M
Generation of a potent chimeric toxin by replacement of domain III of Pseudomonas exotoxin with ricin A chain KDEL.
Bioconjugate chemistry 1995;6(5):624-9.
1995: Sphyris N; Lord J M; Wales R; Roberts L M
Mutational analysis of the Ricinus lectin B-chains. Galactose-binding ability of the 2 gamma subdomain of Ricinus communis agglutinin B-chain.
The Journal of biological chemistry 1995;270(35):20292-7.
1995: Simpson J C; Lord J M; Roberts L M
Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation.
European journal of biochemistry / FEBS 1995;232(2):458-63.
1995: Simpson J C; Dascher C; Roberts L M; Lord J M; Balch W E
Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.
The Journal of biological chemistry 1995;270(34):20078-83.
1995: Pongracz J; Tuffley W; Johnson G D; Deacon E M; Burnett D; Stockley R A; Lord J M
Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells.
Experimental cell research 1995;218(2):430-8.
1995: Pongracz J; Clark P; Neoptolemos J P; Lord J M
Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids.
International journal of cancer. Journal international du cancer 1995;61(1):35-9.
1995: Argent R H; Roberts L M; Lord J M
Purification of recombinant ricin A chain after reassociation with ricin B chain.
Analytical biochemistry 1995;224(1):459-60.
1994: Argent R H; Roberts L M; Wales R; Robertus J D; Lord J M
Introduction of a disulfide bond into ricin A chain decreases the cytotoxicity of the ricin holotoxin.
The Journal of biological chemistry 1994;269(43):26705-10.
1994: Wales R; Gorham H C; Hussain K; Roberts L M; Lord J M
Ricin B chain fragments expressed in Escherichia coli are able to bind free galactose in contrast to the full length polypeptide.
Glycoconjugate journal 1994;11(4):274-81.
1994: Pongracz J; Johnson G D; Crocker J; Burnett D; Lord J M
The role of protein kinase C in myeloid cell apoptosis.
Biochemical Society transactions 1994;22(3):593-7.
1994: Taylor S; Massiah A; Lomonossoff G; Roberts L M; Lord J M; Hartley M
Correlation between the activities of five ribosome-inactivating proteins in depurination of tobacco ribosomes and inhibition of tobacco mosaic virus infection.
The Plant journal : for cell and molecular biology 1994;5(6):827-35.
1994: Chaddock J A; Lord J M; Hartley M R; Roberts L M
Pokeweed antiviral protein (PAP) mutations which permit E.coli growth do not eliminate catalytic activity towards prokaryotic ribosomes.
Nucleic acids research 1994;22(9):1536-40.
1994: Eggo M C; Sheppard M C; Evans F J; Lord J M
Phorbol esters showing selective activation of PKC isozymes in vitro regulate thyroid function and insulin-like growth factor binding protein secretion.
Cellular signalling 1994;6(4):439-48.
1994: Lord J M; Roberts L M; Robertus J D
Ricin: structure, mode of action, and some current applications.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(2):201-8.
1993: Cook J P; Savage P M; Lord J M; Roberts L M
Biologically active interleukin 2-ricin A chain fusion proteins may require intracellular proteolytic cleavage to exhibit a cytotoxic effect.
Bioconjugate chemistry 1993;4(6):440-7.
1993: Wales R; Roberts L M; Lord J M
Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.
The Journal of biological chemistry 1993;268(32):23986-90.
1993: Legname G; Gromo G; Lord J M; Monzini N; Modena D
Expression and activity of pre-dianthin 30 and dianthin 30.
Biochemical and biophysical research communications 1993;192(3):1230-7.
1992: Lord J M; Wales R; Pitcher C; Roberts L M
Cell surface and intracellular functions for galactose binding in ricin cytotoxicity.
Biochemical Society transactions 1992;20(4):734-8.
1992: Wales R; Chaddock J A; Roberts L M; Lord J M
Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin.
Experimental cell research 1992;203(1):1-4.
1992: Westby M; Argent R H; Pitcher C; Lord J M; Roberts L M
Preparation and characterization of recombinant proricin containing an alternative protease-sensitive linker sequence.
Bioconjugate chemistry 1992;3(5):375-81.
1992: Roberts L M; Lord J M
Cytotoxic proteins.
Current opinion in biotechnology 1992;3(4):422-9.
1992: Newton D L; Wales R; Richardson P T; Walbridge S; Saxena S K; Ackerman E J; Roberts L M; Lord J M; Youle R J
Cell surface and intracellular functions for ricin galactose binding.
The Journal of biological chemistry 1992;267(17):11917-22.
1992: Wales R; Richardson P T; Roberts L M; Lord J M
Recombinant ricin B chain fragments containing a single galactose binding site retain lectin activity.
Archives of biochemistry and biophysics 1992;294(1):291-6.
1992: O'Hare M; Roberts L M; Lord J M
Biological activity of recombinant Ricinus communis agglutinin A chain produced in Escherichia coli.
FEBS letters 1992;299(3):209-12.
1992: Roberts L M; Tregear J W; Lord J M
Molecular cloning of ricin.
Targeted diagnosis and therapy 1992;7():81-97.
1992: Lord J M; Roberts L M; Thorpe P E
Chimeric proteins containing ricin A chain.
Targeted diagnosis and therapy 1992;7():183-90.
1992: Jones N A; Lord J M; Brown G
Changes in the phosphorylation status of a 19 kD cytosolic protein are linked to the growth arrest of HL-60 cells.
Leukemia research 1992;16(4):353-61.
1991: Gould J H; Hartley M R; Welsh P C; Hoshizaki D K; Frankel A; Roberts L M; Lord J M
Alteration of an amino acid residue outside the active site of the ricin A chain reduces its toxicity towards yeast ribosomes.
Molecular & general genetics : MGG 1991;230(1-2):81-90.
1991: Wales R; Richardson P T; Roberts L M; Woodland H R; Lord J M
Mutational analysis of the galactose binding ability of recombinant ricin B chain.
The Journal of biological chemistry 1991;266(29):19172-9.
1991: Hartley M R; Legname G; Osborn R; Chen Z; Lord J M
Single-chain ribosome inactivating proteins from plants depurinate Escherichia coli 23S ribosomal RNA.
FEBS letters 1991;290(1-2):65-8.
1991: French P J; Bunce C M; Stephens L R; Lord J M; McConnell F M; Brown G; Creba J A; Michell R H
Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes.
Proceedings. Biological sciences / The Royal Society 1991;245(1314):193-201.
1991: Legname G; Bellosta P; Gromo G; Modena D; Keen J N; Roberts L M; Lord J M
Nucleotide sequence of cDNA coding for dianthin 30, a ribosome inactivating protein from Dianthus caryophyllus.
Biochimica et biophysica acta 1991;1090(1):119-22.
1991: Wood K A; Lord J M; Wawrzynczak E J; Piatak M
Preproabrin: genomic cloning, characterisation and the expression of the A-chain in Escherichia coli.
European journal of biochemistry / FEBS 1991;198(3):723-32.
1991: Richardson P T; Hussain K; Woodland H R; Lord J M; Roberts L M
The effects of N-glycosylation on the lectin activity of recombinant ricin B chain.
Carbohydrate research 1991;213():19-25.
1991: Baxter M A; Grafton G; Bunce C M; Lord J M; Michell R H; Brown G
The role of inositol transport in cellular differentiation.
Biochemical Society transactions 1991;19(2):86S.
1991: Lord J M; Bunce C M; French P J; Jones N A; Baxter M A; Grafton G; Michell R H; Brown G
Protein phosphorylation events and changes in inositol metabolism during HL60 cell differentiation.
Biochemical Society transactions 1991;19(2):315-20.
1991: Lord J M; Hartley M R; Roberts L M
Ribosome inactivating proteins of plants.
Seminars in cell biology 1991;2(1):15-22.
1991: Baxter M A; Bunce C M; Lord J M; French P J; Michell R H; Brown G
Changes in inositol transport during DMSO-induced differentiation of HL60 cells towards neutrophils.
Biochimica et biophysica acta 1991;1091(2):158-64.
1990: Irwin S D; Lord J M
Nucleotide sequence of a Ricinus communis 2S albumin precursor gene.
Nucleic acids research 1990;18(19):5890.
1990: O'Hare M; Brown A N; Hussain K; Gebhardt A; Watson G; Roberts L M; Vitetta E S; Thorpe P E; Lord J M
Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically-cleavable spacer sequence.
FEBS letters 1990;273(1-2):200-4.
1990: Irwin S D; Keen J N; Findlay J B; Lord J M
The Ricinus communis 2S albumin precursor: a single preproprotein may be processed into two different heterodimeric storage proteins.
Molecular & general genetics : MGG 1990;222(2-3):400-8.
1990: Michell R H; Conroy L A; Finney M; French P J; Brown G; Creba J A; Bunce C M; Lord J M
Inositol lipids and phosphates in the regulation of the growth and differentiation of haemopoietic and other cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):193-207.
1990: Bunce C M; Patton W N; Pound J D; Lord J M; Brown G
Phorbol myristate acetate treatment of normal human myeloid blast cells promotes monopoiesis and inhibits granulopoiesis.
Leukemia research 1990;14(11-12):1007-17.
1990: Brown G; Bunce C M; Lord J M
Models of haemopoiesis.
Leukemia research 1990;14(6):495-9.
1990: Michell R H; Conroy L A; French P J; Bunce C M; Lord J M; Brown G; Baxter M A; McConnell F; Creba J A
Inositol lipids and phosphates in the differentiation of blood cells.
Advances in second messenger and phosphoprotein research 1990;24():147-51.
1989: Richardson P T; Westby M; Roberts L M; Gould J H; Colman A; Lord J M
Recombinant proricin binds galactose but does not depurinate 28 S ribosomal RNA.
FEBS letters 1989;255(1):15-20.
1989: Hussain K; Bowler C; Roberts L M; Lord J M
Expression of ricin B chain in Escherichia coli.
FEBS letters 1989;244(2):383-7.
1989: May M J; Hartley M R; Roberts L M; Krieg P A; Osborn R W; Lord J M
Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild-type and mutant polypeptides.
The EMBO journal 1989;8(1):301-8.
1989: Lord J M; Spooner R A; Roberts L M
Immunotoxins: monoclonal antibody-toxin conjugates--a new approach to cancer therapy.
Advances in biotechnological processes 1989;11():193-211.
1988: Brown G; Bunce C M; Lord J M; McConnell F M
The development of cell lineages: a sequential model.
Differentiation; research in biological diversity 1988;39(2):83-9.
1988: Lord J M; Bunce C M; Duncan R J; Phillips I D; Shennan K I; Docherty K; Brown G
Changes in insulin receptor expression in HL60 cells induced to differentiate towards neutrophils or monocytes.
Journal of molecular endocrinology 1988;1(3):197-201.
1988: Bunce C M; Thick J A; Lord J M; Mills D; Brown G
A rapid procedure for isolating hemopoietic cell nuclei.
Analytical biochemistry 1988;175(1):67-73.
1988: Lord J M; Halpin C
Formation of protein bodies and glyoxysomes.
Biochemical Society transactions 1988;16(5):706-8.
1988: Richardson P T; Roberts L M; Gould J H; Lord J M
The expression of functional ricin B-chain in Saccharomyces cerevisiae.
Biochimica et biophysica acta 1988;950(3):385-94.
1988: Lord J M; Thick J A; Bunce C M; Taylor A M; Gallimore P H; Mills D; Brown G
Characterization of a novel nuclear envelope protein restricted to certain cell types.
Journal of cell science 1988;90 ( Pt 2)():237-45.
1987: Lord J M; Roberts L M
Plant toxins.
Microbiological sciences 1987;4(12):376-8.
1987: O'Hare M; Roberts L M; Thorpe P E; Watson G J; Prior B; Lord J M
Expression of ricin A chain in Escherichia coli.
FEBS letters 1987;216(1):73-8.
1987: Lord J M; Gould J; Griffiths D; O'Hare M; Prior B; Richardson P T; Roberts L M
Ricin: cytotoxicity, biosynthesis and use in immunoconjugates.
Progress in medicinal chemistry 1987;24():1-28.

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