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John Lorenz

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Tara N Rindler; Valerie M Lasko; John N Lorenz; Michelle L Nieman; Motoi Okada; Jerry B Lingrel
Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction.
Mannix Auger-Messier; Orlando F Bueno; Sanjeewa A Goonasekera; John N Lorenz; Jop H van Berlo; Robert N Willette; Federica Accornero; Jeffery D Molkentin
Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.
Sheryl E Koch; Valerie M Lasko; Yong Liu; John N Lorenz; Xiaoping Ren; Nathan Robbins; Cole Brokamp; Wenfeng Cai; Xiaoqian Gao; Lauren Haar; Min Jiang; W Keith Jones; Michael Tranter; Priyanka Varma; Hong-Sheng Wang; Jack Rubinstein
Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.

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2013: Tara N Rindler; Valerie M Lasko; John N Lorenz; Michelle L Nieman; Motoi Okada; Jerry B Lingrel
Knockout of the Na,K-ATPase α2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction.
American journal of physiology. Heart and circulatory physiology 2013;304(8):H1147-58.
2013: Mannix Auger-Messier; Orlando F Bueno; Sanjeewa A Goonasekera; John N Lorenz; Jop H van Berlo; Robert N Willette; Federica Accornero; Jeffery D Molkentin
Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.
Circulation research 2013;112(1):48-56.
2012: Sheryl E Koch; Valerie M Lasko; Yong Liu; John N Lorenz; Xiaoping Ren; Nathan Robbins; Cole Brokamp; Wenfeng Cai; Xiaoqian Gao; Lauren Haar; Min Jiang; W Keith Jones; Michael Tranter; Priyanka Varma; Hong-Sheng Wang; Jack Rubinstein
Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.
Journal of molecular and cellular cardiology 2012;53(1):134-44.
2012: Jeffrey M Lynch; Kaari A Lynch; Marjorie Maillet; Bruce J Aronow; N Scott Blair; Jack Lawler; John N Lorenz; Kazutoshi Mori; Tetsuya Okada; Hanna Osinska; Ron Prywes; Jeffrey Robbins; Michelle A Sargent; Aryn Schloemer; Davy Vanhoutte; Jeffery D Molkentin
A thrombospondin-dependent pathway for a protective ER stress response.
Cell 2012;149(6):1257-68.
2012: John N Lorenz; Naomi Oshiro; Elizabeth L Loreaux; Jerry B Lingrel
DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.
American journal of hypertension 2012;25(4):421-9.
2011: Tara N Rindler; Iva Dostanic; Valerie M Lasko; John N Lorenz; Jonathan C Neumann; Michelle L Nieman; Jerry B Lingrel
Knockout of the Na,K-ATPase α₂-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1396-404.
2011: John N Lorenz; Michelle L Nieman; Vikram Prasad; William H Beierwaltes; Thomas Damhoff; Valerie M Lasko; Jerry B Lingrel
Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the α1 or α2 Na-K-ATPase ouabain-binding site.
American journal of physiology. Renal physiology 2011;301(3):F615-21.
2011: Federica Accornero; Matthew J Benard; Peter Carmeliet; John N Lorenz; Jop H van Berlo; Jeffery D Molkentin
Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism.
Circulation research 2011;109(3):272-80.
2011: Sakthivel Sadayappan; Metin Avkiran; David Barefield; Donald M Bers; Joan Heller Brown; Friederike Cuello; James Gulick; Jeanne James; Valerie M Lasko; John N Lorenz; Marjorie Maillet; Jody L Martin; Jeffery D Molkentin; Hanna Osinska; Jeffrey Robbins
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.
Circulation research 2011;109(2):141-50.
2011: Izhak Kehat; Jennifer Davis; Malte Tiburcy; Federica Accornero; Marc K Saba-El-Leil; Marjorie Maillet; Allen York; John N Lorenz; Wolfram H Zimmermann; Sylvain Meloche; Jeffery D Molkentin
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.
Circulation research 2011;108(2):176-83.
2011: Nabeel J Al Moamen; Vikram Prasad; Ilona Bodi; Marian L Miller; Michelle L Neiman; Valerie M Lasko; Seth L Alper; David F Wieczorek; John N Lorenz; Gary E Shull
Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
Journal of molecular and cellular cardiology 2011;50(1):137-46.
2011: Arshani N Wansapura; Valerie M Lasko; Jerry B Lingrel; John N Lorenz
Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology 2011;300(1):H347-55.
2010: Hiroyuki Nakayama; Ilona Bodi; Marjorie Maillet; Jaime DeSantiago; Timothy L Domeier; Katsuhiko Mikoshiba; John N Lorenz; Lothar A Blatter; Donald M Bers; Jeffery D Molkentin
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.
Circulation research 2010;107(5):659-66.
2010: Emily M Bradford; Marian L Miller; Vikram Prasad; Michelle L Nieman; Lara R Gawenis; Mark Berryman; John N Lorenz; Patrick Tso; Gary E Shull
CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;298(6):R1531-42.
2009: Alina Maloyan; Hanna Osinska; Jan Lammerding; Richard T Lee; Oscar Horacio Cingolani; David A Kass; John N Lorenz; Jeffrey Robbins
Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy.
Circulation research 2009;104(8):1021-8.
2009: Sakthivel Sadayappan; James Gulick; Raisa Klevitsky; John N Lorenz; Michelle Sargent; Jeffery D Molkentin; Jeffrey Robbins
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.
Circulation 2009;119(9):1253-62.
2008: Vikram Prasad; Ilona Bodi; Jamie W Meyer; Yigang Wang; Muhammad Ashraf; Sandra J Engle; Thomas Doetschman; Karena Sisco; Michelle L Nieman; Marian L Miller; John N Lorenz; Gary E Shull
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
The Journal of biological chemistry 2008;283(46):31303-14.
2008: Elizabeth L Loreaux; Baksho Kaul; John N Lorenz; Jerry B Lingrel
Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load.
Journal of the American Society of Nephrology : JASN 2008;19(10):1947-54.
2008: John N Lorenz; Elizabeth L Loreaux; Iva Dostanic-Larson; Valerie Lasko; J Renee Schnetzer; Richard J Paul; Jerry B Lingrel
ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H273-80.
2008: Sakthivel Sadayappan; Natosha L Finley; Jack W Howarth; Hanna Osinska; Raisa Klevitsky; John N Lorenz; Paul R Rosevear; Jeffrey Robbins
Role of the acidic N' region of cardiac troponin I in regulating myocardial function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(4):1246-57.
2008: Abhinav Diwan; Janaka Wansapura; Faisal M Syed; Scot J Matkovich; John N Lorenz; Gerald W Dorn
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation.
Circulation 2008;117(3):396-404.
2007: Michael Hambleton; Allen York; Michelle A Sargent; Robert A Kaiser; John N Lorenz; Jeffrey Robbins; Jeffery D Molkentin
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3768-71.
2007: Tracy J Pritchard; Michelle Parvatiyar; Daniel P Bullard; Ronald M Lynch; John N Lorenz; Richard J Paul
Transgenic mice expressing Na+-K+-ATPase in smooth muscle decreases blood pressure.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H1172-82.
2007: Lara R Gawenis; Emily M Bradford; Vikram Prasad; John N Lorenz; Janet E Simpson; Lane L Clarke; Alison L Woo; Christina Grisham; L Philip Sanford; Thomas Doetschman; Marian L Miller; Gary E Shull
Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter.
The Journal of biological chemistry 2007;282(12):9042-52.
2007: JITESH KAWEDIA; Michelle L Nieman; Gregory P Boivin; James E Melvin; Ken-Ichiro Kikuchi; Arthur R Hand; John N Lorenz; Anil G Menon
Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3621-6.
2007: John N Lorenz; Lois J Arend; Rachel Robitz; Richard J Paul; A John MacLennan
Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(1):R440-6.
2006: Sakthivel Sadayappan; Hanna Osinska; Raisa Klevitsky; John N Lorenz; Michelle A Sargent; Jeffery D Molkentin; Christine E Seidman; Jonathan G Seidman; Jeffrey Robbins
Cardiac myosin binding protein C phosphorylation is cardioprotective.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16918-23.
2006: John N Lorenz; Iva Dostanic-Larson; Gary E Shull; Jerry B Lingrel
Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase.
Journal of the American Society of Nephrology : JASN 2006;17(9):2457-63.
2006: Noeet Elitsur; John N Lorenz; Jennifer A Hawkins; Jeffrey A Rudolph; David Witte; Li E Yang; Alicia A McDonough; Mitchell B Cohen
The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response.
Journal of pediatric gastroenterology and nutrition 2006;43 Suppl 1():S74-81.
2006: Iva Dostanic-Larson; John N Lorenz; James W Van Huysse; Jonathan C Neumann; Amy E Moseley; Jerry B Lingrel
Physiological role of the alpha1- and alpha2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(3):R524-8.
2006: Jian Xu; Thomas R Kimball; John N Lorenz; David A Brown; Asne R Bauskin; Raisa Klevitsky; Timothy E Hewett; Samuel N Breit; Jeffery D Molkentin
GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.
Circulation research 2006;98(3):342-50.
2006: Susan M Wall; Mark A Knepper; Kathryn A Hassell; Michael P Fischer; Adetola Shodeinde; Wonkyong Shin; Truyen Derek Pham; Jamie W Meyer; John N Lorenz; William H Beierwaltes; John R Dietz; Gary E Shull; Young-Hee Kim
Hypotension in NKCC1 null mice: role of the kidneys.
American journal of physiology. Renal physiology 2006;290(2):F409-16.
2005: Iva Dostanic-Larson; James W Van Huysse; John N Lorenz; Jerry B Lingrel
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15845-50.
2005: Anand Pathak; Federica del Monte; Wen Zhao; Jo-El Schultz; John N Lorenz; Ilona Bodi; Doug Weiser; Harvey Hahn; Andrew N Carr; Faisal M Syed; Nirmala Mavila; Leena Jha; Jiang Qian; Yehia Marreez; Guoli Chen; Dennis W McGraw; E Kevin Heist; J Luis Guerrero; Anna A DePaoli-Roach; Roger J Hajjar; Evangelia G Kranias
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.
Circulation research 2005;96(7):756-66.
2005: William T Noonan; Alison L Woo; Michelle L Nieman; Vikram Prasad; Patrick J Schultheis; Gary E Shull; John N Lorenz
Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(3):R685-91.
2005: Iva Dostanic; Richard J Paul; John N Lorenz; Steven Theriault; James W Van Huysse; Jerry B Lingrel
The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.
American journal of physiology. Heart and circulatory physiology 2005;288(2):H477-85.
2005: Sadayappan Sakthivel; Natosha L Finley; Paul R Rosevear; John N Lorenz; James Gulick; Scott Kim; Peter VanBuren; Lisa A Martin; Jeffrey Robbins
In vivo and in vitro analysis of cardiac troponin I phosphorylation.
The Journal of biological chemistry 2005;280(1):703-14.
2005: Amy E Moseley; Justin P Huddleson; Cynthia S Bohanan; Paul F James; John N Lorenz; Bruce Aronow; Jerry B Lingrel
Genetic profiling reveals global changes in multiple biological pathways in the hearts of Na, K-ATPase alpha 1 isoform haploinsufficient mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;15(1-4):145-58.
2004: Iva Dostanic; Jo El J Schultz; John N Lorenz; Jerry B Lingrel
The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart.
The Journal of biological chemistry 2004;279(52):54053-61.
2004: A Kumar; K Crawford; R Flick; Raisa Klevitsky; John N Lorenz; K E Bove; Jeffrey Robbins; James L Lessard
Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression.
Transgenic research 2004;13(6):531-40.
2004: Michael E Christe; Najia Jin; Xushan Wang; Kenneth E Gould; Philip W Iversen; Xiaohong Yu; John N Lorenz; Vivek J Kadambi; Steve H Zuckerman; Laura J Bloem
Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.
Journal of molecular and cellular cardiology 2004;37(3):705-15.
2004: John G Quinlan; Harvey S Hahn; Brenda L Wong; John N Lorenz; Alexandra Wenisch; Linda S Levin
Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings.
Neuromuscular disorders : NMD 2004;14(8-9):491-6.
2004: Daniel J Lips; Orlando F Bueno; Benjamin J Wilkins; Nicole H Purcell; Robert A Kaiser; John N Lorenz; Laure Voisin; Marc K Saba-El-Leil; Sylvain Meloche; Jacques Pouysségur; Gilles Pagès; Leon J De Windt; Pieter A Doevendans; Jeffery D Molkentin
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.
Circulation 2004;109(16):1938-41.
2004: Julian C Braz; Kimberly Gregory; Anand Pathak; Wen Zhao; Bogachan Sahin; Raisa Klevitsky; Thomas F Kimball; John N Lorenz; Angus Nairn; Stephen B Liggett; Ilona Bodi; Su Wang; Arnold Schwartz; Edward G Lakatta; Anna A DePaoli-Roach; Jeffrey Robbins; Timothy E Hewett; James A Bibb; Margaret V Westfall; Evangelia G Kranias; Jeffery D Molkentin
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Nature medicine 2004;10(3):248-54.
2004: Jo El J Schultz; Betty J Glascock; Sandra A Witt; Michelle L Nieman; Kalpana J Nattamai; Lynne H Liu; John N Lorenz; Gary E Shull; Thomas R Kimball; Muthu Periasamy
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.
American journal of physiology. Heart and circulatory physiology 2004;286(3):H1146-53.
2003: Iva Dostanic; John N Lorenz; Jo El J Schultz; Ingrid L Grupp; Jonathan C Neumann; Maqsood Wani; Jerry B Lingrel
The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice.
The Journal of biological chemistry 2003;278(52):53026-34.
2003: William T Noonan; Jin Qian; William D Stuart; Thomas Landes Clemens; John N Lorenz
Altered renal hemodynamics in mice overexpressing the parathyroid hormone (PTH)/PTH-related peptide type 1 receptor in smooth muscle.
Endocrinology 2003;144(11):4931-8.
2003: John N Lorenz; Michelle L Nieman; Jenine Sabo; L Philip Sanford; Jennifer A Hawkins; Noeet Elitsur; Lara R Gawenis; Lane L Clarke; Mitchell B Cohen
Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load.
The Journal of clinical investigation 2003;112(8):1244-54.
2003: Mary Donoghue; Hiroko Wakimoto; Colin T Maguire; Susan Acton; Paul Hales; Nancy Stagliano; Victoria Fairchild-Huntress; Jian Xu; John N Lorenz; Vivek J Kadambi; Charles I Berul; Roger E Breitbart
Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins.
Journal of molecular and cellular cardiology 2003;35(9):1043-53.
2003: Yong Ji; Bailing Li; Thomas D Reed; John N Lorenz; Marcia A Kaetzel; John R Dedman
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
The Journal of biological chemistry 2003;278(27):25063-71.
2003: Alison L Woo; William T Noonan; Patrick J Schultheis; Jonathan C Neumann; Patrice A Manning; John N Lorenz; Gary E Shull
Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect.
American journal of physiology. Renal physiology 2003;284(6):F1190-8.
2003: Maike Krenz; Atsushi Sanbe; Florence Bouyer-Dalloz; James Gulick; Raisa Klevitsky; Timothy E Hewett; Hanna Osinska; John N Lorenz; Christine Brosseau; Andrea Federico; Norman R Alpert; David M Warshaw; M Benjamin Perryman; Steve M Helmke; Jeffrey Robbins
Analysis of myosin heavy chain functionality in the heart.
The Journal of biological chemistry 2003;278(19):17466-74.
2003: Gary E Shull; Gbolahan Okunade; Lynne H Liu; Peter J Kozel; Muthu Periasamy; John N Lorenz; Vikram Prasad
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.
Annals of the New York Academy of Sciences 2003;986():453-60.
2003: William T Noonan; John N Lorenz
Clearance studies in genetically altered mice.
Methods in molecular medicine 2003;86():315-27.
2002: Albrecht G Schmidt; Jing Zhai; Andrew N Carr; Michael J Gerst; John N Lorenz; Piero Pollesello; Arto Annila; Brian D Hoit; Evangelia G Kranias
Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure.
Cardiovascular research 2002;56(2):248-59.
2002: Jamie W Meyer; Michael Flagella; Roy L Sutliff; John N Lorenz; Michelle L Nieman; Craig S Weber; Richard J Paul; Gary E Shull
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter.
American journal of physiology. Heart and circulatory physiology 2002;283(5):H1846-55.
2002: John N Lorenz; Nancy R Baird; Louise M Judd; William T Noonan; Anastasia Andringa; Thomas Doetschman; Patrice A Manning; Lynne H Liu; Marian L Miller; Gary E Shull
Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.
The Journal of biological chemistry 2002;277(40):37871-80.
2002: Kathy Pieples; Grace M Arteaga; R John Solaro; Ingrid L Grupp; John N Lorenz; Gregory P Boivin; Ganapathy Jagatheesan; Erin Hall (Maiden: Labitzke); Pieter DeTombe; John P Konhilas; Thomas C Irving; David F Wieczorek
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1344-53.
2002: Sabine Huke; Vikram Prasad; Michelle L Nieman; Kalpana J Nattamai; Ingrid L Grupp; John N Lorenz; Muthu Periasamy
Altered dose response to beta-agonists in SERCA1a-expressing hearts ex vivo and in vivo.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H958-65.
2002: Martin G Yussman; Tsuyoshi Toyokawa; Amy Odley; Roy A Lynch; Guangyu Wu; Melissa C Colbert; Bruce Aronow; John N Lorenz; Gerald W Dorn
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy.
Nature medicine 2002;8(7):725-30.
2002: John N Lorenz
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(6):R1565-82.
2002: Orlando F Bueno; Benjamin J Wilkins; Kevin M Tymitz; Betty J Glascock; Thomas F Kimball; John N Lorenz; Jeffery D Molkentin
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4586-91.
2001: Carissa M Krane; CN Fortner; A R Hand; Dennis W McGraw; John N Lorenz; Susan E Wert; JE Towne; Richard J Paul; Jeffrey A Whitsett; Anil G Menon
Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14114-9.
2001: Clara Ledoussal; John N Lorenz; Michelle L Nieman; Manoocher Soleimani; Patrick J Schultheis; Gary E Shull
Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2.
American journal of physiology. Renal physiology 2001;281(4):F718-27.
2001: Xuejun Wang; Hanna Osinska; Gerald W Dorn; Michelle L Nieman; John N Lorenz; A Martin Gerdes; Sandra Witt; T Kimball; James Gulick; Jeffrey Robbins
Mouse model of desmin-related cardiomyopathy.
Circulation 2001;103(19):2402-7.
2001: Rajesh Dash; Vivek J Kadambi; Albrecht G Schmidt; NM Tepe; Danuta Biniakiewicz; Michael J Gerst; AM Canning; William T Abraham; Brian D Hoit; Stephen B Liggett; John N Lorenz; Gerald W Dorn; Evangelia G Kranias
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Circulation 2001;103(6):889-96.
2001: CN Fortner; John N Lorenz; Richard J Paul
Chloride channel function is linked to epithelium-dependent airway relaxation.
American journal of physiology. Lung cellular and molecular physiology 2001;280(2):L334-41.
2001: Heddwen L Brooks; A M Sorensen; James M Terris; Patrick J Schultheis; John N Lorenz; Gary E Shull; Mark A Knepper
Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics.
The Journal of physiology 2001;530(Pt 3):359-66.
2001: John N Lorenz
Considerations for the evaluation of renal function in genetically engineered mice.
Current opinion in nephrology and hypertension 2001;10(1):65-9.
2000: Daria Mochly-Rosen; Guangyu Wu; Harvey Hahn; Hanna Osinska; Tamar Liron; John N Lorenz; Atsuko Yatani; J Robbins; Gerald W Dorn
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation.
Circulation research 2000;86(11):1173-9.
2000: Stephen B Liggett; NM Tepe; John N Lorenz; AM Canning; T D Jantz; S Mitarai; Atsuko Yatani; Gerald W Dorn
Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level.
Circulation 2000;101(14):1707-14.
2000: K M Galvin; M J Donovan; CA Lynch; R I Meyer; R J Paul; John N Lorenz; Victoria Fairchild-Huntress; K L Dixon; Judy H Dunmore; Michael A Gimbrone; D Falb; Dennis Huszar
A role for smad6 in development and homeostasis of the cardiovascular system.
Nature genetics 2000;24(2):171-4.
1999: NM Tepe; John N Lorenz; Atsuko Yatani; Rajesh Dash; Evangelia G Kranias; Gerald W Dorn; Stephen B Liggett
Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling.
Biochemistry 1999;38(50):16706-13.
1999: Gerald W Dorn; M C Souroujon; Tamar Liron; CH Chen; Mary O Gray; Hui-Zhong Zhou; M Csukai; Guangyu Wu; John N Lorenz; Daria Mochly-Rosen
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12798-803.
1999: Michael Flagella; Lane L Clarke; Marian L Miller; Lawrence C Erway; Ralph A Giannella; Anastasia Andringa; Lara R Gawenis; J Kramer; JJ Duffy; Thomas Doetschman; John N Lorenz; Ebenezer N Yamoah; Emma Lou Cardell; Gary E Shull
Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf.
The Journal of biological chemistry 1999;274(38):26946-55.
1999: J E Schultz; Sandra A Witt; Michelle L Nieman; Peter J Reiser; Sandra J Engle; M Zhou; Sharon Pawlowski; John N Lorenz; Thomas R Kimball; Thomas Doetschman
Fibroblast growth factor-2 mediates pressure-induced hypertrophic response.
The Journal of clinical investigation 1999;104(6):709-19.
1999: John N Lorenz; Patrick J Schultheis; Tim R Traynor; Gary E Shull; Jurgen Schnermann
Micropuncture analysis of single-nephron function in NHE3-deficient mice.
The American journal of physiology 1999;277(3 Pt 2):F447-53.
1999: Gerald W Dorn; NM Tepe; John N Lorenz; Walter J Koch; Stephen B Liggett
Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6400-5.
1999: Jin Qian; John N Lorenz; S Maeda; Roy L Sutliff; C Weber; T Nakayama; Melissa C Colbert; Richard J Paul; James A Fagin; Thomas Landes Clemens
Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle.
Endocrinology 1999;140(4):1826-33.
1999: S Maeda; Roy L Sutliff; Jin Qian; John N Lorenz; J Wang; H Tang; T Nakayama; C Weber; David Witte; AR Strauch; Richard J Paul; James A Fagin; Thomas Landes Clemens
Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility.
Endocrinology 1999;140(4):1815-25.
1999: Muthu Periasamy; Thomas D Reed; Lynne H Liu; Yong Ji; EV Loukianov; Richard J Paul; Michelle L Nieman; Tara M Riddle; JJ Duffy; Thomas Doetschman; John N Lorenz; Gary E Shull
Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene.
The Journal of biological chemistry 1999;274(4):2556-62.
1999: John N Lorenz; Eric I Gruenstein
A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin.
The American journal of physiology 1999;276(1 Pt 2):F172-7.
1998: Patrick J Schultheis; John N Lorenz; Pierre Meneton; Michelle L Nieman; Tara M Riddle; Michael Flagella; JJ Duffy; Thomas Doetschman; Marian L Miller; Gary E Shull
Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule.
The Journal of biological chemistry 1998;273(44):29150-5.
1998: Ingrid L Grupp; John N Lorenz; Richard A Walsh; Gregory P Boivin; H Rindt
Overexpression of alpha1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy.
The American journal of physiology 1998;275(4 Pt 2):H1338-50.
1998: M G Stockelman; John N Lorenz; Frost N L Smith; Gregory P Boivin; Amrik Sahota; Jay A Tischfield; Peter J Stambrook
Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency.
The American journal of physiology 1998;275(1 Pt 2):F154-63.
1998: Patrick J Schultheis; Lane L Clarke; Pierre Meneton; Marian L Miller; Manoocher Soleimani; Lara R Gawenis; Tara M Riddle; JJ Duffy; Thomas Doetschman; T Wang; Gerhard Giebisch; Peter S Aronson; John N Lorenz; Gary E Shull
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger.
Nature genetics 1998;19(3):282-5.
1998: R V Williams; John N Lorenz; Sandra A Witt; D T Hellard; P R Khoury; Thomas R Kimball
End-systolic stress-velocity and pressure-dimension relationships by transthoracic echocardiography in mice.
The American journal of physiology 1998;274(5 Pt 2):H1828-35.
1998: M Zhou; Roy L Sutliff; Richard J Paul; John N Lorenz; James B Hoying; Christian Haudenschild; M Yin; J D Coffin; L Kong; Evangelia G Kranias; W Luo; Gregory P Boivin; JJ Duffy; Sharon Pawlowski; Thomas Doetschman
Fibroblast growth factor 2 control of vascular tone.
Nature medicine 1998;4(2):201-7.
1998: Pierre Meneton; Patrick J Schultheis; J Greeb; Michelle L Nieman; Lynne H Liu; Lane L Clarke; JJ Duffy; Thomas Doetschman; John N Lorenz; Gary E Shull
Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice.
The Journal of clinical investigation 1998;101(3):536-42.
1997: John N Lorenz; Evangelia G Kranias
Regulatory effects of phospholamban on cardiac function in intact mice.
The American journal of physiology 1997;273(6 Pt 2):H2826-31.
1997: Lynne H Liu; Richard J Paul; Roy L Sutliff; Marian L Miller; John N Lorenz; Raymund Y K Pun; JJ Duffy; Thomas Doetschman; Y Kimura; David H MacLennan; James B Hoying; Gary E Shull
Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3.
The Journal of biological chemistry 1997;272(48):30538-45.
1997: Melissa C Colbert; DG Hall; Thomas R Kimball; Sandra A Witt; John N Lorenz; M L Kirby; T E Hewett; Raisa Klevitsky; Jeffrey Robbins
Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.
The Journal of clinical investigation 1997;100(8):1958-68.
1997: D D D'Angelo; Y Sakata; John N Lorenz; Gregory P Boivin; R A Walsh; Stephen B Liggett; Gerald W Dorn
Transgenic Galphaq overexpression induces cardiac contractile failure in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8121-6.
1997: John N Lorenz; Jeffrey Robbins
Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse.
The American journal of physiology 1997;272(3 Pt 2):H1137-46.
1997: E S Tam; DG Ferguson; D R Bielefeld; John N Lorenz; R M Cohen; Raymund Y K Pun
Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat.
Cell calcium 1997;21(2):143-50.
1997: John N Lorenz; Richard J Paul
Dependence of Ca2+ channel currents on endogenous and exogenous sources of ATP in portal vein smooth muscle.
The American journal of physiology 1997;272(2 Pt 2):H987-94.
1996: J Turki; John N Lorenz; Stuart A Green; E T Donnelly; M Jacinto; Stephen B Liggett
Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10483-8.
1994: John N Lorenz; D R Bielefeld; Nicholas Sperelakis
Regulation of calcium channel current in A7r5 vascular smooth muscle cells by cyclic nucleotides.
The American journal of physiology 1994;266(6 Pt 1):C1656-63.