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Aurelio Lorico

Research Profile

Living Beings

Mouse

Chemicals & Drugs

Anatomy

Physiology

Disorders

Leukemia L1210

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Publications

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Germana Rappa; Michaela Wilsch-Bräuninger; Javier Mercapide; Fabio Anzanello; Denis Corbeil; Ronald R Fiscus; Mary G Johlfs; Thuc T Le; Aurelio Lorico
Wnt interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells.
Aurelio Lorico; Javier Mercapide; Germana Rappa
Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives.
Javier Mercapide; Germana Rappa; Aurelio Lorico
The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironment.

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All Publications

2013: Germana Rappa; Michaela Wilsch-Bräuninger; Javier Mercapide; Fabio Anzanello; Denis Corbeil; Ronald R Fiscus; Mary G Johlfs; Thuc T Le; Aurelio Lorico
Wnt interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells.
Experimental cell research 2013;319(6):810-9.
2013: Aurelio Lorico; Javier Mercapide; Germana Rappa
Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives.
Advances in experimental medicine and biology 2013;777():197-211.
2012: Javier Mercapide; Germana Rappa; Aurelio Lorico
The intrinsic fusogenicity of glioma cells as a factor of transformation and progression in the tumor microenvironment.
International journal of cancer. Journal international du cancer 2012;131(2):334-43.
2012: Germana Rappa; Javier Mercapide; Aurelio Lorico
Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity.
The American journal of pathology 2012;180(6):2504-15.
2012: Javier Mercapide; Germana Rappa; Fabio Anzanello; Aurelio Lorico
Relationship between tumor cell invasiveness and polyploidization.
PloS one 2012;7(12):e53364.
2011: Germana Rappa; Fabio Anzanello; Aurelio Lorico
Imatinib mesylate enhances the malignant behavior of human breast carcinoma cells.
Cancer chemotherapy and pharmacology 2011;67(4):919-26.
2011: Bo Lu; Shih-Hwa Chiou; Eric Deutsch; Aurelio Lorico
Cancer stem cells.
Journal of oncology 2011;2011():269437.
2011: Aurelio Lorico; Germana Rappa
Phenotypic heterogeneity of breast cancer stem cells.
Journal of oncology 2011;2011():135039.
2010: Germana Rappa; Aurelio Lorico
Phenotypic characterization of mammosphere-forming cells from the human MA-11 breast carcinoma cell line.
Experimental cell research 2010;316(9):1576-86.
2010: Javier Mercapide; Germana Rappa; Fabio Anzanello; Judy King; Oystein Fodstad; Aurelio Lorico
Primary gene-engineered neural stem/progenitor cells demonstrate tumor-selective migration and antitumor effects in glioma.
International journal of cancer. Journal international du cancer 2010;126(5):1206-15.
2008: Aurelio Lorico; Javier Mercapide; V Solodushko; V Soloduschko; M Alexeyev; Oystein Fodstad; G Rappa
Primary neural stem/progenitor cells expressing endostatin or cytochrome P450 for gene therapy of glioblastoma.
Cancer gene therapy 2008;15(9):605-15.
2008: Germana Rappa; Javier Mercapide; Fabio Anzanello; Lina Prasmickaite; Yaguang Xi; Jingfang Ju; Oystein Fodstad; Aurelio Lorico
Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets.
Experimental cell research 2008;314(10):2110-22.
2007: Germana Rappa; Fabio Anzanello; Mikhail Alexeyev; Oystein Fodstad; Aurelio Lorico
Gamma-glutamylcysteine synthetase-based selection strategy for gene therapy of chronic granulomatous disease and graft-vs.-host disease.
European journal of haematology 2007;78(5):440-8.
2005: Aurelio Lorico; Daniel Bratbak; Johann Meyer; David Kunke; Stefan Krauss; Walter E Plott; Viktoriya Solodushko; Christopher Baum; Oystein Fodstad; Germana Rappa
Gamma-glutamylcysteine synthetase and L-buthionine-(S,R)-sulfoximine: a new selection strategy for gene-transduced neural and hematopoietic stem/progenitor cells.
Human gene therapy 2005;16(6):711-24.
2004: Germana Rappa; David Kunke; J Holter; Dzung B Diep; J Meyer; Christopher Baum; Oystein Fodstad; Stefan Krauss; Aurelio Lorico
Efficient expansion and gene transduction of mouse neural stem/progenitor cells on recombinant fibronectin.
Neuroscience 2004;124(4):823-30.
2003: salvatore cisternino; Christophe Rousselle; Aurelio Lorico; Germana Rappa; Jean-Michel Scherrmann
Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells.
Pharmaceutical research 2003;20(6):904-9.
2003: Germana Rappa; M P Gamcsik; R L Mitina; Christopher Baum; Oystein Fodstad; Aurelio Lorico
Retroviral transfer of MRP1 and gamma-glutamyl cysteine synthetase modulates cell sensitivity to L-buthionine-S,R-sulphoximine (BSO): new rationale for the use of BSO in cancer therapy.
European journal of cancer (Oxford, England : 1990) 2003;39(1):120-8.
2002: Aurelio Lorico; Antonella Bertola; Christopher Baum; Oystein Fodstad; Germana Rappa
Role of the Multidrug Resistance Protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice.
Biochemical and biophysical research communications 2002;291(3):617-22.
2002: Aurelio Lorico; Jahn Nesland; Elisabeth Emilsen; Oystein Fodstad; Germana Rappa
Role of the multidrug resistance protein 1 gene in the carcinogenicity of aflatoxin B1: investigations using mrp1-null mice.
Toxicology 2002;171(2-3):201-5.
2001: Germana Rappa; Aurelio Lorico; M Hildinger; Øystein Fodstad; Christopher Baum
Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents.
Human gene therapy 2001;12(14):1785-96.
2001: Edward H Abraham; Kenneth M Sterling; R J Kim; Anna Y Salikhova; H B Huffman; M A Crockett; N Johnston; H W Parker; W E Boyle; Alex Hartov; Eugene Demidenko; J Efird; J Kahn; Shelley A Grubman; Douglas M Jefferson; S C Robson; J H Thakar; Aurelio Lorico; Germana Rappa; Alan C Sartorelli; P Okunieff
Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis.
Blood cells, molecules & diseases 2001;27(1):165-80.
2000: John R Murren; Susan A DiStasio; Aurelio Lorico; Anne McKeon; E G Zuhowski; Merrill J Egorin; Alan C Sartorelli; Germana Rappa
Phase I and pharmacokinetic study of novobiocin in combination with VP-16 in patients with refractory malignancies.
Cancer journal (Sudbury, Mass.) 2000;6(4):256-65.
2000: Germana Rappa; John R Murren; L M Johnson; Aurelio Lorico; Alan C Sartorelli
Novobiocin-induced VP-16 accumulation and MRP expression in human leukemia and ovarian carcinoma cells.
Anti-cancer drug design 2000;15(2):127-34.
2000: Germana Rappa; Krishnamurthy Shyam; Aurelio Lorico; Oystein Fodstad; Alan C Sartorelli
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16).
Oncology research 2000;12(3):113-9.
1999: Germana Rappa; Rick A Finch; Alan C Sartorelli; Aurelio Lorico
New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models.
Biochemical pharmacology 1999;58(4):557-62.
1997: Aurelio Lorico; Germana Rappa; Rick A Finch; D Yang; Richard A Flavell; Alan C Sartorelli
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
Cancer research 1997;57(23):5238-42.
1997: Germana Rappa; Aurelio Lorico; Richard A Flavell; Alan C Sartorelli
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.
Cancer research 1997;57(23):5232-7.
1997: Germana Rappa; Aurelio Lorico; Mao-Chin Liu; Gary Kruh; Ann H Cory; Joseph G Cory; Alan C Sartorelli
Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase.
Biochemical pharmacology 1997;54(6):649-55.
1997: Joseph G Cory; Ann H Cory; Aurelio Lorico; Germana Rappa; Alan C Sartorelli
Altered efflux properties of mouse leukemia L1210 cells resistant to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone.
Anticancer research 1997;17(5A):3185-93.
1996: Aurelio Lorico; Germana Rappa; Richard A Flavell; Alan C Sartorelli
Double knockout of the MRP gene leads to increased drug sensitivity in vitro.
Cancer research 1996;56(23):5351-5.
1995: Aurelio Lorico; Germana Rappa; S Srimatkandada; Carlo V Catapano; Daniel J Fernandes; J F Germino; Alan C Sartorelli
Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene.
Cancer research 1995;55(19):4352-60.
1995: Joseph G Cory; Ann H Cory; Germana Rappa; Aurelio Lorico; Mao-Chin Liu; T S Lin; Alan C Sartorelli
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo.
Advances in enzyme regulation 1995;35():55-68.
1994: Joseph G Cory; Ann H Cory; Germana Rappa; Aurelio Lorico; Mao-Chin Liu; T S Lin; Alan C Sartorelli
Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.
Biochemical pharmacology 1994;48(2):335-44.
1993: Germana Rappa; Aurelio Lorico; Alan C Sartorelli
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin.
Cancer research 1993;53(22):5487-93.
1993: Aurelio Lorico; Byron H Long
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II.
European journal of cancer (Oxford, England : 1990) 1993;29A(14):1985-91.
1992: Aurelio Lorico; Germana Rappa; Alan C Sartorelli
Novobiocin-induced accumulation of etoposide (VP-16) in WEHI-3B D+ leukemia cells.
International journal of cancer. Journal international du cancer 1992;52(6):903-9.
1992: Germana Rappa; Aurelio Lorico; Alan C Sartorelli
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
International journal of cancer. Journal international du cancer 1992;51(5):780-7.
1992: Germana Rappa; Aurelio Lorico; Alan C Sartorelli
Development and characterization of a WEHI-3B D+ monomyelocytic leukemia cell line resistant to novobiocin and cross-resistant to other topoisomerase II-targeted drugs.
Cancer research 1992;52(10):2782-90.
1992: Eugenio Erba; S Sen; Aurelio Lorico; Maurizio D'Incalci
Potentiation of etoposide cytotoxicity against a human ovarian cancer cell line by pretreatment with non-toxic concentrations of methotrexate or aphidicolin.
European journal of cancer (Oxford, England : 1990) 1992;28(1):66-71.
1991: Byron H Long; L Wang; Aurelio Lorico; R C Wang; M G Brattain; A M Casazza
Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines.
Cancer research 1991;51(19):5275-83.
1990: Germana Rappa; Aurelio Lorico; Alan C Sartorelli
Induction of the differentiation of WEHI-3B D+ monomyelocytic leukemia cells by inhibitors of topoisomerase II.
Cancer research 1990;50(20):6723-30.
1990: Aurelio Lorico; Mauro Boiocchi; Germana Rappa; S Sen; Eugenio Erba; M D'Incalci
Increase in topoisomerase-II-mediated DNA breaks and cytotoxicity of VP16 in human U937 lymphoma cells pretreated with low doses of methotrexate.
International journal of cancer. Journal international du cancer 1990;45(1):156-62.
1988: Aurelio Lorico; Giuseppe Toffoli; Mauro Boiocchi; Eugenio Erba; M Broggini; Germana Rappa; M D'Incalci
Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate.
Biochemical pharmacology 1988;37(9):1875-6.
1988: Aurelio Lorico; Germana Rappa; Mauro Boiocchi; F Anzanello; M D'Incalci
Increase in etoposide-induced topoisomerase II-mediated DNA breaks after cell synchronization induced by low doses of methotrexate.
Biochemical pharmacology 1988;37(9):1883-4.
1988: Aurelio Lorico; Giuseppe Toffoli; Mauro Boiocchi; Eugenio Erba; M Broggini; Germana Rappa; M D'Incalci
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.
Cancer research 1988;48(8):2036-41.
1988: Giuseppe Toffoli; Aurelio Lorico; Mauro Boiocchi
Changes in chemosensitivity of K 562 leukemia cells after induction of erythroid differentiation by hemin.
Tumori 1988;74(1):11-7.
1986: Eugenio Erba; S Pepe; Paolo Ubezio; Aurelio Lorico; L Morasca; C Mangioni; Fabio Landoni; M D'Incalci
Mitozolomide activity on human cancer cells in vitro.
British journal of cancer 1986;54(6):925-32.