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Jon Lorsch

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Saccharomyces cerevisiae

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Jagpreet S Nanda; Adesh K Saini; Alan G Hinnebusch; Antonio M Muñoz; Jon R Lorsch
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.
Sarah E Walker; Fujun Zhou; Alan G Hinnebusch; Victoria S Larson; Sarah F Mitchell; Leos Valasek; Jon R Lorsch
Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.
Eun-Hee Park; Vaishnavi Rajagopal; Sarah E Walker; Fujun Zhou; Joseph M Lee; Jon R Lorsch; Alan G Hinnebusch
Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo.

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All Publications

2013: Jagpreet S Nanda; Adesh K Saini; Alan G Hinnebusch; Antonio M Muñoz; Jon R Lorsch
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.
The Journal of biological chemistry 2013;288(8):5316-29.
2013: Sarah E Walker; Fujun Zhou; Alan G Hinnebusch; Victoria S Larson; Sarah F Mitchell; Leos Valasek; Jon R Lorsch
Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.
RNA (New York, N.Y.) 2013;19(2):191-207.
2013: Eun-Hee Park; Vaishnavi Rajagopal; Sarah E Walker; Fujun Zhou; Joseph M Lee; Jon R Lorsch; Alan G Hinnebusch
Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo.
The Journal of biological chemistry 2013;288(4):2340-54.
2013: Rachel C Allen; Alexander S Bobbs; Joseph W Friesen; Jon R Lorsch; John A McCauley; Michael J Nevarez; Yen-Kuei Tu; Judith G Voet; Nancy V Hamlett
The mercury resistance (mer) operon in a marine gliding flavobacterium, Tenacibaculum discolor 9A5.
FEMS microbiology ecology 2013;83(1):135-48.
2012: Rafael E Luna; Assen Marintchev; Michelle A Markus; Pilar Martin-Marcos; Alexander G Milbradt; David Miles; Jagpreet S Nanda; Elizabeth M O'Day; Mikhail Reibarkh; Hee-Chan Seo; Barak Akabayov; Haribabu Arthanari; Katsura Asano; Amr Fahmy; Patrick R Hagner; Alan G Hinnebusch; Hiroyuki Hiraishi; Sven G Hyberts; Jon R Lorsch; Lunet E Luna; Tingfang Yi; Gerhard Wagner
The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.
Cell reports 2012;1(6):689-702.
2012: Vaishnavi Rajagopal; Eun-Hee Park; Alan G Hinnebusch; Jon R Lorsch
Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.
The Journal of biological chemistry 2012;287(24):20301-12.
2012: Colin Echeverría Aitken; Jon R Lorsch
A mechanistic overview of translation initiation in eukaryotes.
Nature structural & molecular biology 2012;19(6):568-76.
2012: Alan G Hinnebusch; Jon R Lorsch
The mechanism of eukaryotic translation initiation: new insights and challenges.
Cold Spring Harbor perspectives in biology 2012;4(10):.
2011: Byung-Sik Shin; Sarah E Walker; Jinsheng Dong; Joo-Ran Kim; Jon R Lorsch; Thomas E Dever
Initiation factor eIF2γ promotes eIF2-GTP-Met-tRNAi(Met) ternary complex binding to the 40S ribosome.
Nature structural & molecular biology 2011;18(11):1227-34.
2011: Jon R Lorsch; David G Nichols
Organizing graduate life sciences education around nodes and connections.
Cell 2011;146(4):506-9.
2011: Byung-Sik Shin; Michael G Acker; Joo-Ran Kim; Kathryn N Maher; Shamsul M Arefin; Jon R Lorsch; Thomas E Dever
Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.
RNA (New York, N.Y.) 2011;17(4):687-96.
2011: Julie E Takacs; Timothy B Neary; Nicholas T Ingolia; Adesh K Saini; Pilar Martin-Marcos; Jerry Pelletier; Alan G Hinnebusch; Jon R Lorsch
Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.
RNA (New York, N.Y.) 2011;17(3):439-52.
2011: Eun-Hee Park; Sarah E Walker; Joseph M Lee; Stefan Rothenburg; Jon R Lorsch; Alan G Hinnebusch
Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo.
The EMBO journal 2011;30(2):302-16.
2010: Sarah F Mitchell; Sarah E Walker; Mikkel A Algire; Eun-Hee Park; Alan G Hinnebusch; Jon R Lorsch
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.
Molecular cell 2010;39(6):950-62.
2010: Jon R Lorsch; Thomas E Dever
Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.
The Journal of biological chemistry 2010;285(28):21203-7.
2010: Shinya Kurata; Klaus H Nielsen; Sarah F Mitchell; Jon R Lorsch; Akira Kaji; Hideko Kaji
Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):10854-9.
2010: Sarah E Kolitz; Jon R Lorsch
Eukaryotic initiator tRNA: finely tuned and ready for action.
FEBS letters 2010;584(2):396-404.
2010: Adesh Saini; Jagpreet S Nanda; Jon R Lorsch; Alan G Hinnebusch
Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.
Genes & development 2010;24(1):97-110.
2009: Jagpreet S Nanda; Yuen-Nei Cheung; Julie E Takacs; Pilar Martin-Marcos; Adesh Saini; Alan G Hinnebusch; Jon R Lorsch
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.
Journal of molecular biology 2009;394(2):268-85.
2009: Byung-Sik Shin; Joo-Ran Kim; Michael Acker; Kathryn N Maher; Jon R Lorsch; Thomas E Dever
rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.
Molecular and cellular biology 2009;29(3):808-21.
2009: Michael Acker; Byung-Sik Shin; Jagpreet S Nanda; Adesh Saini; Thomas E Dever; Jon R Lorsch
Kinetic analysis of late steps of eukaryotic translation initiation.
Journal of molecular biology 2009;385(2):491-506.
2009: Sarah E Kolitz; Julie E Takacs; Jon R Lorsch
Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiation.
RNA (New York, N.Y.) 2009;15(1):138-52.
2008: Sarah F Mitchell; Jon R Lorsch
Should I stay or should I go? Eukaryotic translation initiation factors 1 and 1A control start codon recognition.
The Journal of biological chemistry 2008;283(41):27345-9.
2008: Jinsheng Dong; Jagpreet S Nanda; Hafsa Rahman; Margaret R Pruitt; Byung-Sik Shin; Chi-Ming Wong; Jon R Lorsch; Alan G Hinnebusch
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection.
Genes & development 2008;22(16):2242-55.
2008: Michael Acker; Jon R Lorsch
Mechanism of ribosomal subunit joining during eukaryotic translation initiation.
Biochemical Society transactions 2008;36(Pt 4):653-7.
2007: Yuen-Nei Cheung; David Maag; Sarah F Mitchell; Christie A Fekete; Mikkel A Algire; Julie E Takacs; Nikolay Shirokikh; Tatyana V Pestova; Jon R Lorsch; Alan G Hinnebusch
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.
Genes & development 2007;21(10):1217-30.
2007: Lori A Passmore; T Martin Schmeing; David Maag; Drew J Applefield; Michael Acker; Mikkel A Algire; Jon R Lorsch; Venki Ramakrishnan
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.
Molecular cell 2007;26(1):41-50.
2007: Christie A Fekete; Sarah F Mitchell; Vera A Cherkasova; Drew J Applefield; Mikkel A Algire; David Maag; Adesh Saini; Jon R Lorsch; Alan G Hinnebusch
N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection.
The EMBO journal 2007;26(6):1602-14.
2007: Jeanne M Fringer; Michael Acker; Christie A Fekete; Jon R Lorsch; Thomas E Dever
Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.
Molecular and cellular biology 2007;27(6):2384-97.
2007: Byung-Sik Shin; Michael Acker; David Maag; Joo-Ran Kim; Jon R Lorsch; Thomas E Dever
Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant.
Molecular and cellular biology 2007;27(5):1677-85.
2007: Michael Acker; Sarah E Kolitz; Sarah F Mitchell; Jagpreet S Nanda; Jon R Lorsch
Reconstitution of yeast translation initiation.
Methods in enzymology 2007;430():111-45.
2006: Francis Robert; Lee Kapp; Shakila N Khan; Michael Acker; Sarah E Kolitz; Shirin Kazemi; Randal J Kaufman; William C Merrick; Antonis E Koromilas; Jon R Lorsch; Jerry Pelletier
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability.
Molecular biology of the cell 2006;17(11):4632-44.
2006: Mikkel A Algire; Jon R Lorsch
Where to begin? The mechanism of translation initiation codon selection in eukaryotes.
Current opinion in chemical biology 2006;10(5):480-6.
2006: Lee Kapp; Sarah E Kolitz; Jon R Lorsch
Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation.
RNA (New York, N.Y.) 2006;12(5):751-64.
2006: Michael Acker; Byung-Sik Shin; Thomas E Dever; Jon R Lorsch
Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.
The Journal of biological chemistry 2006;281(13):8469-75.
2006: David Maag; Mikkel A Algire; Jon R Lorsch
Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selection.
Journal of molecular biology 2006;356(3):724-37.
2005: Mikkel A Algire; David Maag; Jon R Lorsch
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.
Molecular cell 2005;20(2):251-62.
2005: Christie A Fekete; Drew J Applefield; Stephen A Blakely; Nikolay Shirokikh; Tatyana V Pestova; Jon R Lorsch; Alan G Hinnebusch
The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.
The EMBO journal 2005;24(20):3588-601.
2005: Jennifer A Doudna; Jon R Lorsch
Ribozyme catalysis: not different, just worse.
Nature structural & molecular biology 2005;12(5):395-402.
2005: David Maag; Christie A Fekete; Zygmunt Gryczynski; Jon R Lorsch
A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon.
Molecular cell 2005;17(2):265-75.
2004: Lee Kapp; Jon R Lorsch
GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2.
Journal of molecular biology 2004;335(4):923-36.
2004: Lee Kapp; Jon R Lorsch
The molecular mechanics of eukaryotic translation.
Annual review of biochemistry 2004;73():657-704.
2003: David Maag; Jon R Lorsch
Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit.
Journal of molecular biology 2003;330(5):917-24.
2002: Byung-Sik Shin; David Maag; Antonina Roll-Mecak; M Shamsul Arefin; Stephen K Burley; Jon R Lorsch; Thomas E Dever
Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.
Cell 2002;111(7):1015-25.
2002: Marjolaine Carriere; Veerappan Vijayabaskar; Drew J Applefield; Isabelle Harvey; Philippe Garneau; Jon R Lorsch; Aviva Lapidot; Jerry Pelletier
Inhibition of protein synthesis by aminoglycoside-arginine conjugates.
RNA (New York, N.Y.) 2002;8(10):1267-79.
2002: Rachel Green; Jon R Lorsch
The path to perdition is paved with protons.
Cell 2002;110(6):665-8.
2002: Jon R Lorsch
RNA chaperones exist and DEAD box proteins get a life.
Cell 2002;109(7):797-800.
2002: Mikkel A Algire; David Maag; Peter Savio; Michael Acker; Salvador Z Tarun; Alan B Sachs; Katsura Asano; Klaus H Nielsen; Deanne S Olsen; Lon Phan; Alan G Hinnebusch; Jon R Lorsch
Development and characterization of a reconstituted yeast translation initiation system.
RNA (New York, N.Y.) 2002;8(3):382-97.
2001: Jeremy Berg; Jon R Lorsch
Mechanism of ribosomal peptide bond formation.
Science (New York, N.Y.) 2001;291(5502):203.
1999: Jon R Lorsch; Daniel Herschlag
Kinetic dissection of fundamental processes of eukaryotic translation initiation in vitro.
The EMBO journal 1999;18(23):6705-17.
1998: Jon R Lorsch; Daniel Herschlag
The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes.
Biochemistry 1998;37(8):2194-206.
1998: Jon R Lorsch; Daniel Herschlag
The DEAD box protein eIF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide.
Biochemistry 1998;37(8):2180-93.
1996: Jon R Lorsch; Jack W Szostak
Chance and necessity in the selection of nucleic acid catalysts.
Accounts of chemical research 1996;29(2):103-10.
1995: Jon R Lorsch; Jack W Szostak
Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme.
Biochemistry 1995;34(46):15315-27.
1995: Jon R Lorsch; D P Bartel; Jack W Szostak
Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template.
Nucleic acids research 1995;23(15):2811-4.
1994: Jon R Lorsch; Jack W Szostak
In vitro evolution of new ribozymes with polynucleotide kinase activity.
Nature 1994;371(6492):31-6.
1994: Jon R Lorsch; Jack W Szostak
In vitro selection of RNA aptamers specific for cyanocobalamin.
Biochemistry 1994;33(4):973-82.
1986: Ruth Ruprecht; Jon R Lorsch; D H Trites
Analysis of suramin plasma levels by ion-pair high-performance liquid chromatography under isocratic conditions.
Journal of chromatography 1986;378(2):498-502.