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Michael Barrett

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Chemicals & Drugs

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Trypanosomiasis, African

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TOP 3
Michael P Barrett; Curtis G Gemmell; Colin J Suckling
Minor groove binders as anti-infective agents.
Darren J Creek; Dong-Hyun Kim; Keith R Matthews; Brunda Nijagal; Federico Rojas; Michael P Barrett
Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei.
Achuthanunni Chokkathukalam; Darren J Creek; Andris Jankevics; Fiona Achcar; Michael P Barrett; Rainer Breitling
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data.

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All Publications

2013: Michael P Barrett; Curtis G Gemmell; Colin J Suckling
Minor groove binders as anti-infective agents.
Pharmacology & therapeutics 2013;139(1):12-23.
2013: Darren J Creek; Dong-Hyun Kim; Keith R Matthews; Brunda Nijagal; Federico Rojas; Michael P Barrett
Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei.
Antimicrobial agents and chemotherapy 2013;57(6):2768-79.
2013: Achuthanunni Chokkathukalam; Darren J Creek; Andris Jankevics; Fiona Achcar; Michael P Barrett; Rainer Breitling
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data.
Bioinformatics (Oxford, England) 2013;29(2):281-3.
2012: Darren J Creek; Andris Jankevics; Rainer Breitling; Karl E V Burgess; Achuthanunni Chokkathukalam; Michael P Barrett
Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation.
Analytical chemistry 2012;84(20):8442-7.
2012: Darren J Creek; Andris Jankevics; Rainer Breitling; Karl E V Burgess; Michael P Barrett
IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data.
Bioinformatics (Oxford, England) 2012;28(7):1048-9.
2012: Darren J Creek; Malcolm J McConville; Jana Anderson; Michael P Barrett
Metabolomic analysis of trypanosomatid protozoa.
Molecular and biochemical parasitology 2012;181(2):73-84.
2012: Anoop Menachery; Steven L Neale; Pui E Wong; Michael P Barrett; Allan Carlsson; Clemens Kremer; Jonathan M Cooper
Counterflow dielectrophoresis for trypanosome enrichment and detection in blood.
Scientific reports 2012;2():775.
2012: Isabel M Vincent; Debra J Woods; Richard J S Burchmore; Karl Burgess; Darren J Creek; Michael P Barrett
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.
PLoS neglected tropical diseases 2012;6(5):e1618.
2012: Fiona Achcar; Barbara M Bakker; Michael P Barrett; Eduard J Kerkhoven; Rainer Breitling
Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism.
PLoS computational biology 2012;8(1):e1002352.
2011: Karl Burgess; Ken Cook; Darren Creek; Paul Dewsbury; Michael P Barrett
Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry.
Rapid communications in mass spectrometry : RCM 2011;25(22):3447-52.
2011: David P Leader; Karl Burgess; Darren Creek; Michael P Barrett
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry.
Rapid communications in mass spectrometry : RCM 2011;25(22):3422-6.
2011: Darren J Creek; Andris Jankevics; David G Watson; Michael P Barrett; Rainer Breitling; Karl E V Burgess
Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction.
Analytical chemistry 2011;83(22):8703-10.
2011: Michael P Barrett; Richard J S Burchmore; Anne J N Kazibwe; Isabel M Vincent; Enock Matovu
Drug resistance in human African trypanosomiasis.
Future microbiology 2011;6(9):1037-47.
2011: Jean Rodgers; Christopher McCabe; Michael P Barrett; Barbara Bradley; George Gettinby; Stéphane Gibaud; Amy Jones; Peter G E Kennedy
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
PLoS neglected tropical diseases 2011;5(9):e1308.
2011: Sabine A Stoffel; Vincent P Alibu; Frédéric Bringaud; Charles Ebikeme; Jane Hubert; Jean-Charles Portais; M Ernst Schweingruber; Michael P Barrett
Transketolase in Trypanosoma brucei.
Molecular and biochemical parasitology 2011;179(1):1-7.
2011: Ibrahim A Teka; Christopher P Ward; Mohammed I Al-Salabi; Michael P Barrett; Nasser El-Sabbagh; Anthonius A Eze; Anne J N Kazibwe; Pascal Mäser; Enock Matovu; Jane C Munday; Harry P De Koning
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
Molecular pharmacology 2011;80(1):110-6.
2011: Christopher P Ward; Pui Ee Wong; Richard J Burchmore; Harry P de Koning; Michael P Barrett
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.
Antimicrobial agents and chemotherapy 2011;55(5):2352-61.
2011: Richard J A Goodwin; Andrew Pitt; David Harrison; Stefan K Weidt; Pat R R Langridge-Smith; Michael P Barrett; C Logan Mackay
Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry.
Rapid communications in mass spectrometry : RCM 2011;25(7):969-72.
2010: Michael P Barrett
Potential new drugs for human African trypanosomiasis: some progress at last.
Current opinion in infectious diseases 2010;23(6):603-8.
2010: Christopher P Ward; Karl E V Burgess; Richard J S Burchmore; Michael P Barrett; Harry P De Koning
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.
Molecular and biochemical parasitology 2010;174(2):145-9.
2010: Gian Filippo Ruda; Pui Ee Wong; Vincent P Alibu; Suzanne Norval; Kevin D Read; Michael P Barrett; Ian H Gilbert
Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.
Journal of medicinal chemistry 2010;53(16):6071-8.
2010: Nina Klee; Pui Ee Wong; Beatriz Baragaña; Farah El Mazouni; Margaret A Phillips; Michael P Barrett; Ian H Gilbert
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.
Bioorganic & medicinal chemistry letters 2010;20(15):4364-6.
2010: Michael P Barrett; Barbara M Bakker; Rainer Breitling
Metabolomic systems biology of trypanosomes.
Parasitology 2010;137(9):1285-90.
2010: Gian Filippo Ruda; Gordon Campbell; Vincent P Alibu; Michael P Barrett; Ruth Brenk; Ian H Gilbert
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
Bioorganic & medicinal chemistry 2010;18(14):5056-62.
2010: Mhairi L Stewart; Richard J S Burchmore; Caroline Clucas; Christiane Hertz-Fowler; Karen Brooks; Andy Tait; Annette MacLeod; C Michael R Turner; Harry P De Koning; Pui Ee Wong; Michael P Barrett
Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.
Eukaryotic cell 2010;9(2):336-43.
2010: Isabel M Vincent; Darren Creek; David G Watson; Mohammed A Kamleh; Debra J Woods; Pui Ee Wong; Richard J S Burchmore; Michael P Barrett
A molecular mechanism for eflornithine resistance in African trypanosomes.
PLoS pathogens 2010;6(11):e1001204.
2009: Catharine J Collar; Mohammed I Al-Salabi; Mhairi L Stewart; Michael P Barrett; W David Wilson; Harry P de Koning
Predictive computational models of substrate binding by a nucleoside transporter.
The Journal of biological chemistry 2009;284(49):34028-35.
2009: A Mukhopadhyay; C-Y Chen; C Doerig; F L Henriquez; Craig William Roberts; Michael P Barrett
The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.
Parasitology 2009;136(7):747-55.
2009: Jean Rodgers; Trevor W Stone; Michael P Barrett; Barbara Bradley; Peter G E Kennedy
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
Brain : a journal of neurology 2009;132(Pt 5):1259-67.
2009: Alessandro Baliani; Valerie Peal; Ludovic Gros; Reto Brun; Marcel Kaiser; Michael P Barrett; Ian H Gilbert
Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites.
Organic & biomolecular chemistry 2009;7(6):1154-66.
2009: Constance Chollet; Alessandro Baliani; Pui Ee Wong; Michael P Barrett; Ian H Gilbert
Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
Bioorganic & medicinal chemistry 2009;17(6):2512-23.
2009: Anne J N Kazibwe; Barbara Nerima; Harry P De Koning; Pascal Mäser; Michael P Barrett; Enock Matovu
Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.
PLoS neglected tropical diseases 2009;3(9):e523.
2008: Caroline M Reid; Charles Ebikeme; Michael P Barrett; Eva-Maria Patzewitz; Sylke Müller; David J Robins; Andrew Sutherland
Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis.
Bioorganic & medicinal chemistry letters 2008;18(20):5399-401.
2008: Virginie Coustou; Marc Biran; Marc Breton; Fabien Guegan; Loïc Rivière; Nicolas Plazolles; Derek Nolan; Michael P Barrett; Jean-Michel Franconi; Frédéric Bringaud
Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei.
The Journal of biological chemistry 2008;283(24):16342-54.
2008: Christina Naula; Vincent P Alibu; Janice M Brock; Nicola J Veitch; Richard J S Burchmore; Michael P Barrett
A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase.
Journal of biochemical and biophysical methods 2008;70(6):1185-7.
2008: Caroline M Reid; Charles Ebikeme; Michael P Barrett; Eva-Maria Patzewitz; Sylke Müller; David J Robins; Andrew Sutherland
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.
Bioorganic & medicinal chemistry letters 2008;18(7):2455-8.
2007: Jennifer M Wilson; Federica Giordani; Louis J Farrugia; Michael P Barrett; David J Robins; Andrew Sutherland
Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.
Organic & biomolecular chemistry 2007;5(22):3651-6.
2007: Gian Filippo Ruda; Vincent P Alibu; Christos Mitsos; Olivier Bidet; Marcel Kaiser; Reto Brun; Michael P Barrett; Ian H Gilbert
Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.
ChemMedChem 2007;2(8):1169-80.
2007: Patrick O J Ogbunude; Nadia Lamour; Michael P Barrett
Molecular cloning, expression and characterization of ribokinase of Leishmania major.
Acta biochimica et biophysica Sinica 2007;39(6):462-6.
2007: Ramasubramanian Sundaramoorthy; Jorge Iulek; Michael P Barrett; Olivier Bidet; Gian Filippo Ruda; Ian H Gilbert; William N Hunter
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates.
The FEBS journal 2007;274(1):275-86.
2006: Charlotte A Lanteri; Mhairi L Stewart; Janice M Brock; Vincent P Alibu; Steven R Meshnick; Richard R Tidwell; Michael P Barrett
Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance.
Molecular pharmacology 2006;70(5):1585-92.
2006: Christophe Dardonville; Michael P Barrett; Reto Brun; Marcel Kaiser; Farial A Tanious; David W. Wilson
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.
Journal of medicinal chemistry 2006;49(12):3748-52.
2006: Michael P Barrett
The rise and fall of sleeping sickness.
Lancet 2006;367(9520):1377-8.
2006: Michael P Barrett; Ian H Gilbert
Targeting of toxic compounds to the trypanosome's interior.
Advances in parasitology 2006;63():125-83.
2006: B M Anene; RC Ezeokonkwo; T I Mmesirionye; Justice Tettey; Janice M Brock; Michael P Barrett; Harry P De Koning
A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.
Parasitology 2006;132(Pt 1):127-33.
2005: Mhairi L Stewart; Cyrille Boussard; Reto Brun; Ian H Gilbert; Michael P Barrett
Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.
Antimicrobial agents and chemotherapy 2005;49(12):5169-71.
2005: Alessandro Baliani; Gorka Jimenez Bueno; Mhairi L Stewart; Vanessa Yardley; Reto Brun; Michael P Barrett; Ian H Gilbert
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
Journal of medicinal chemistry 2005;48(17):5570-9.
2005: Mhairi L Stewart; Sanjeev Krishna; Richard J S Burchmore; Reto Brun; Harry P De Koning; David W Boykin; Richard R Tidwell; J Ed Hall; Michael P Barrett
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.
Lancet 2005;366(9484):486-7.
2005: Fiona Seow; Shigeharu Sato; Christoph S Janssen; Mathis O. Riehle; Arunima Mukhopadhyay; R Stephen Phillips; R J M Iain Wilson; Michael P Barrett
The plastidic DNA replication enzyme complex of Plasmodium falciparum.
Molecular and biochemical parasitology 2005;141(2):145-153.
2005: Sébastien Besteiro; Michael P Barrett; Loïc Rivière; Frédéric Bringaud
Energy generation in insect stages of Trypanosoma brucei: metabolism in flux.
Trends in parasitology 2005;21(4):185-91.
2005: Nadia Lamour; Loïc Rivière; Virginie Coustou; Graham H Coombs; Michael P Barrett; Frédéric Bringaud
Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose.
The Journal of biological chemistry 2005;280(12):11902-10.
2004: Stefania Hanau; Eliana Rinaldi; Franco Dallocchio; Ian H Gilbert; Christophe Dardonville; Margaret J Adams; Sheila Gover; Michael P Barrett
6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.
Current medicinal chemistry 2004;11(19):2639-50.
2004: Nicola J Veitch; Dante Maugeri; Juan J Cazzulo; Ylva Lindqvist; Michael P Barrett
Transketolase from Leishmania mexicana has a dual subcellular localization.
The Biochemical journal 2004;382(Pt 2):759-67.
2004: Christophe Dardonville; Eliana Rinaldi; Michael P Barrett; Reto Brun; Ian H Gilbert; Stefania Hanau
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
Journal of medicinal chemistry 2004;47(13):3427-37.
2004: Mhairi L Stewart; Gorka Jimenez Bueno; Alessandro Baliani; Burkhard Klenke; Reto Brun; Janice M Brock; Ian H Gilbert; Michael P Barrett
Trypanocidal activity of melamine-based nitroheterocycles.
Antimicrobial agents and chemotherapy 2004;48(5):1733-8.
2004: Harry P De Koning; Laura F Anderson; Mhairi Stewart; Richard J S Burchmore; Lynsey J M Wallace; Michael P Barrett
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.
Antimicrobial agents and chemotherapy 2004;48(5):1515-9.
2004: Laurent Azema; Samantha Claustre; Isabelle Alric; Casimir Blonski; Michèle Willson; Jacques Perié; Théo Baltz; Emmanuel Tetaud; Frédéric Bringaud; Dominique Cottem; Fred R Opperdoes; Michael P Barrett
Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter.
Biochemical pharmacology 2004;67(3):459-67.
2004: Christoph S Janssen; R Stephen Phillips; C Michael R Turner; Michael P Barrett
Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites.
Nucleic acids research 2004;32(19):5712-20.
2003: Michael P Barrett; Richard J S Burchmore; August Stich; Julio O Lazzari; Alberto C C Frasch; Juan J Cazzulo; Sanjeev Krishna
The trypanosomiases.
Lancet 2003;362(9394):1469-80.
2003: Enock Matovu; Mhairi L Stewart; Federico Geiser; Reto Brun; Pascal Mäser; Lynsey J M Wallace; Richard J S Burchmore; John C K Enyaru; Michael P Barrett; Ronald Kaminsky; Thomas Seebeck; Harry P De Koning
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Eukaryotic cell 2003;2(5):1003-8.
2003: Bertin Enanga; Mark R Ariyanayagam; Mhairi L Stewart; Michael P Barrett
Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.
Antimicrobial agents and chemotherapy 2003;47(10):3368-70.
2003: Dante Maugeri; Juan J Cazzulo; Richard J S Burchmore; Michael P Barrett; Patrick O J Ogbunude
Pentose phosphate metabolism in Leishmania mexicana.
Molecular and biochemical parasitology 2003;130(2):117-25.
2003: Burkhard Klenke; Michael P Barrett; Reto Brun; Ian H Gilbert
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines.
The Journal of antimicrobial chemotherapy 2003;52(2):290-3.
2003: Christophe Dardonville; Eliana Rinaldi; Stefania Hanau; Michael P Barrett; Reto Brun; Ian H Gilbert
Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.
Bioorganic & medicinal chemistry 2003;11(14):3205-14.
2003: Richard J S Burchmore; Lynsey J M Wallace; Denise Candlish; Mohammed I Al-Salabi; Paul R Beal; Michael P Barrett; Stephen A Baldwin; Harry P De Koning
Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan.
The Journal of biological chemistry 2003;278(26):23502-7.
2003: Patrick G Bray; Michael P Barrett; Stephen A Ward; Harry P De Koning
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
Trends in parasitology 2003;19(5):232-9.
2003: August Stich; Michael P Barrett; Sanjeev Krishna
Waking up to sleeping sickness.
Trends in parasitology 2003;19(5):195-7.
2003: Richard J S Burchmore; Dayana D Rodriguez; Kathleen McBride; Patrick Merkel; Michael P Barrett; Govind Modi; David Sacks; Scott M Landfear
Genetic characterization of glucose transporter function in Leishmania mexicana.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3901-6.
2002: Mireille Basselin; Hubert Denise; Graham H Coombs; Michael P Barrett
Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.
Antimicrobial agents and chemotherapy 2002;46(12):3731-8.
2002: Bertin Enanga; Richard J S Burchmore; Mhairi L Stewart; Michael P Barrett
Sleeping sickness and the brain.
Cellular and molecular life sciences : CMLS 2002;59(5):845-58.
2002: Michael P Barrett; Ian H Gilbert
Perspectives for new drugs against trypanosomiasis and leishmaniasis.
Current topics in medicinal chemistry 2002;2(5):471-82.
2002: Christoph S Janssen; Michael P Barrett; C Michael R Turner; R Stephen Phillips
A large gene family for putative variant antigens shared by human and rodent malaria parasites.
Proceedings. Biological sciences / The Royal Society 2002;269(1489):431-6.
2002: Richard J S Burchmore; Patrick O J Ogbunude; Bertin Enanga; Michael P Barrett
Chemotherapy of human African trypanosomiasis.
Current pharmaceutical design 2002;8(4):256-67.
2001: Burkhard Klenke; M Stewart; Michael P Barrett; Reto Brun; Ian H Gilbert
Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.
Journal of medicinal chemistry 2001;44(21):3440-52.
2001: Richard J S Burchmore; Michael P Barrett
Life in vacuoles--nutrient acquisition by Leishmania amastigotes.
International journal for parasitology 2001;31(12):1311-20.
2001: Michael P Barrett
Veterinary link to drug resistance in human African trypanosomiasis?
Lancet 2001;358(9282):603-4.
2001: M Bertelli; E El-Bastawissy; Michael Knaggs; Michael P Barrett; Stefania Hanau; Ian H Gilbert
Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.
Journal of computer-aided molecular design 2001;15(5):465-75.
2001: Christoph S Janssen; Michael P Barrett; Daniel Lawson; Michael A Quail; David Harris; Sharen Bowman; R Stephen Phillips; C Michael R Turner
Gene discovery in Plasmodium chabaudi by genome survey sequencing.
Molecular and biochemical parasitology 2001;113(2):251-60.
2001: Hubert Denise; Michael P Barrett
Uptake and mode of action of drugs used against sleeping sickness.
Biochemical pharmacology 2001;61(1):1-5.
2000: M P Hasne; Michael P Barrett
Transport of methionine in Trypanosoma brucei brucei.
Molecular and biochemical parasitology 2000;111(2):299-307.
2000: M Hasne; Michael P Barrett
Drug uptake via nutrient transporters in Trypanosoma brucei.
Journal of applied microbiology 2000;89(4):697-701.
2000: Cécile Vedrenne; Frédéric Bringaud; Michael P Barrett; Emmanuel Tetaud; Théo Baltz
The structure-function relationship of functionally distinct but structurally similar hexose transporters from Trypanosoma congolense.
European journal of biochemistry / FEBS 2000;267(15):4850-60.
2000: Mireille Basselin; Graham H Coombs; Michael P Barrett
Putrescine and spermidine transport in Leishmania.
Molecular and biochemical parasitology 2000;109(1):37-46.
2000: Michael P Barrett; Alan H Fairlamb; B Rousseau; G Chauvière; J Perié
Uptake of the nitroimidazole drug megazol by African trypanosomes.
Biochemical pharmacology 2000;59(6):615-20.
2000: Harry P De Koning; A MacLeod; Michael P Barrett; B Cover; Simon M Jarvis
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
Molecular and biochemical parasitology 2000;106(1):181-5.
2000: S V Barrett; Michael P Barrett
Anti-sleeping sickness drugs and cancer chemotherapy.
Parasitology today (Personal ed.) 2000;16(1):7-9.
1999: Nicola S Carter; Michael P Barrett; Harry P De Koning
A drug resistance determinant in Trypanosoma brucei.
Trends in microbiology 1999;7(12):469-71.
1999: Michael P Barrett; Adrian R Walmsley; Gwyn W Gould
Structure and function of facilitative sugar transporters.
Current opinion in cell biology 1999;11(4):496-502.
1999: Michael P Barrett
The fall and rise of sleeping sickness.
Lancet 1999;353(9159):1113-4.
1999: Michael P Barrett; Alan H Fairlamb
The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.
Parasitology today (Personal ed.) 1999;15(4):136-40.
1999: Emmanuel Tetaud; Stefania Hanau; Jerry M Wells; Richard Le Page; Margaret J Adams; S Arkison; Michael P Barrett
6-Phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme.
The Biochemical journal 1999;338 ( Pt 1)():55-60.
1999: Hubert Denise; K Matthews; G Lindergård; S Croft; Michael P Barrett
Trypanosomiasis and leishmaniasis: between the idea and the reality of control.
Parasitology today (Personal ed.) 1999;15(2):43-5.
1999: Michael P Barrett; Jeremy C Mottram; Graham H Coombs
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.
Trends in microbiology 1999;7(2):82-8.
1999: Hubert Denise; Christiane Giroud; Michael P Barrett; Théo Baltz
Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan.
European journal of biochemistry / FEBS 1999;259(1-2):339-46.
1998: M Rippa; P P Giovannini; Michael P Barrett; Franco Dallocchio; Stefania Hanau
6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species.
Biochimica et biophysica acta 1998;1429(1):83-92.
1998: Adrian R Walmsley; Michael P Barrett; Frédéric Bringaud; Gwyn W Gould
Sugar transporters from bacteria, parasites and mammals: structure-activity relationships.
Trends in biochemical sciences 1998;23(12):476-81.
1998: Emmanuel Tetaud; David Hall; David G Gourley; Gordon A Leonard; S Arkison; Michael P Barrett; William N Hunter
Crystallization and preliminary X-ray diffraction studies of 6-phosphogluconate dehydrogenase from Lactococcus lactis.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1422-4.
1998: C Phillips; J Dohnalek; Sheila Gover; Michael P Barrett; Margaret J Adams
A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues.
Journal of molecular biology 1998;282(3):667-81.
1998: Emmanuel Tetaud; F Manai; Michael P Barrett; K Nadeau; C T Walsh; Alan H Fairlamb
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
The Journal of biological chemistry 1998;273(31):19383-90.
1998: Michael P Barrett; Emmanuel Tetaud; A Seyfang; Frédéric Bringaud; Théo Baltz
Trypanosome glucose transporters.
Molecular and biochemical parasitology 1998;91(1):195-205.
1997: P P Giovannini; M Rippa; Franco Dallocchio; M Tetaud; Michael P Barrett; Stefania Hanau
The cross-linking by o-phthalaldehyde of two amino acid residues at the active site of 6-phosphogluconate dehydrogenase.
Biochemistry and molecular biology international 1997;43(1):153-60.
1997: Emmanuel Tetaud; Michael P Barrett; Frédéric Bringaud; Théo Baltz
Kinetoplastid glucose transporters.
The Biochemical journal 1997;325 ( Pt 3)():569-80.
1997: Michael P Barrett; Annette MacLeod; J Tovar; J P Sweetman; Andy Tait; Richard Le Page; Sara E Melville
A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates.
Molecular and biochemical parasitology 1997;86(1):95-9.
1997: Michael P Barrett
The pentose phosphate pathway and parasitic protozoa.
Parasitology today (Personal ed.) 1997;13(1):11-6.
1996: Stefania Hanau; M Rippa; M Bertelli; Franco Dallocchio; Michael P Barrett
6-Phosphogluconate dehydrogenase from Trypanosoma brucei. Kinetic analysis and inhibition by trypanocidal drugs.
European journal of biochemistry / FEBS 1996;240(3):592-9.
1996: Emmanuel Tetaud; S Chabas; Christiane Giroud; Michael P Barrett; Théo Baltz
Hexose uptake in Trypanosoma cruzi: structure-activity relationship between substrate and transporter.
The Biochemical journal 1996;317 ( Pt 2)():353-9.
1995: Michael P Barrett; Emmanuel Tetaud; A Seyfang; Frédéric Bringaud; Théo Baltz
Functional expression and characterization of the Trypanosoma brucei procyclic glucose transporter, THT2.
The Biochemical journal 1995;312 ( Pt 3)():687-91.
1995: Michael P Barrett; Z Q Zhang; Hubert Denise; Christiane Giroud; Théo Baltz
A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.
Molecular and biochemical parasitology 1995;73(1-2):223-9.
1994: Emmanuel Tetaud; Frédéric Bringaud; S Chabas; Michael P Barrett; Théo Baltz
Characterization of glucose transport and cloning of a hexose transporter gene in Trypanosoma cruzi.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8278-82.
1994: Michael P Barrett; C Phillips; Margaret J Adams; Richard Le Page
Overexpression in Escherichia coli and purification of the 6-phosphogluconate dehydrogenase of Trypanosoma brucei.
Protein expression and purification 1994;5(1):44-9.
1993: C Phillips; Michael P Barrett; Sheila Gover; Richard Le Page; Margaret J Adams
Preliminary crystallographic study of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.
Journal of molecular biology 1993;233(2):317-21.
1993: Michael P Barrett; Richard Le Page
A 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei.
Molecular and biochemical parasitology 1993;57(1):89-99.
1990: R W LePage; Michael P Barrett
Cloning of the 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei by complementation in Escherichia coli.
Biochemical Society transactions 1990;18(5):724-7.