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Régine Losson

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

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Publications

TOP 3
Benjamin Herquel; Bernard Jost; Céline Keime; Stéphanie Le Gras; Thierry Lerouge; Régine Losson; Igor Martianov; Khalid Ouararhni; Tao Ye; Florence Cammas; Irwin Davidson
Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA.
Florence Cammas; Pierre Chambon; Konstantin Khetchoumian; Régine Losson
TRIM involvement in transcriptional regulation.
Johan Tisserand; Christelle Thibault; Pierre Chambon; Doulaye Dembélé; Konstantin Khetchoumian; Régine Losson
Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition.

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All Publications

2013: Benjamin Herquel; Bernard Jost; Céline Keime; Stéphanie Le Gras; Thierry Lerouge; Régine Losson; Igor Martianov; Khalid Ouararhni; Tao Ye; Florence Cammas; Irwin Davidson
Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA.
Nature structural & molecular biology 2013;20(3):339-46.
2012: Florence Cammas; Pierre Chambon; Konstantin Khetchoumian; Régine Losson
TRIM involvement in transcriptional regulation.
Advances in experimental medicine and biology 2012;770():59-76.
2011: Johan Tisserand; Christelle Thibault; Pierre Chambon; Doulaye Dembélé; Konstantin Khetchoumian; Régine Losson
Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition.
The Journal of biological chemistry 2011;286(38):33369-79.
2011: Benjamin Herquel; Khalid Ouararhni; Konstantin Khetchoumian; Mihaela Ignat; Marius Teletin; Manuel Mark; Guillaume Béchade; Alain Van Dorsselaer; Sarah Sanglier-Cianférani; Ali Hamiche; Florence Cammas; Irwin Davidson; Régine Losson
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(20):8212-7.
2011: Marielle Herzog; Olivia Wendling; Florian Guillou; Pierre Chambon; Manuel Mark; Régine Losson; Florence Cammas
TIF1β association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.
Developmental biology 2011;350(2):548-58.
2010: Søren Kahns; Régine Losson; Anders Lade Nielsen
Nizp1 zinc finger protein localization is determined by SCAN-domain inclusion regulated through alternative splicing.
Biochimica et biophysica acta 2010;1799(8):539-45.
2010: Régine Losson; Anders L Nielsen
The NIZP1 KRAB and C2HR domains cross-talk for transcriptional regulation.
Biochimica et biophysica acta 2010;1799(5-6):463-8.
2009: Raphaël Riclet; Mariam Chendeb; Jean-Luc Vonesch; Dirk Koczan; Hans-Juergen Thiesen; Régine Losson; Florence Cammas
Disruption of the interaction between transcriptional intermediary factor 1{beta} and heterochromatin protein 1 leads to a switch from DNA hyper- to hypomethylation and H3K9 to H3K27 trimethylation on the MEST promoter correlating with gene reactivation.
Molecular biology of the cell 2009;20(1):296-305.
2008: Mihaela Ignat; Marius Teletin; Johan Tisserand; Konstantin Khetchoumian; Christine Dennefeld; Pierre Chambon; Régine Losson; Manuel Mark
Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2598-603.
2008: Anas Fadloun; Dominique Kobi; L Delacroix; Doulaye Dembélé; I Michel; A Lardenois; J Tisserand; Régine Losson; Mengus Gabrielle; Irwin Davidson
Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
Oncogene 2008;27(4):477-89.
2007: Konstantin Khetchoumian; Marius Teletin; Johan Tisserand; Manuel Mark; Benjamin Herquel; Mihaela Ignat; Jessica Zucman-Rossi; Florence Cammas; Thierry Lerouge; Christelle Thibault; Daniel Metzger; Pierre Chambon; Régine Losson
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.
Nature genetics 2007;39(12):1500-6.
2007: Florence Cammas; Agnes Janoshazi; Thierry Lerouge; Régine Losson
Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation.
Differentiation; research in biological diversity 2007;75(7):627-37.
2006: Catherine Teyssier; Chen-Yin Ou; Konstantin Khetchoumian; Régine Losson; Michael R Stallcup
Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators.
Molecular endocrinology (Baltimore, Md.) 2006;20(6):1276-86.
2005: Marie J Lucey; Dongsheng Chen; Jorge Lopez-Garcia; Stephen M Hart; Fladia Phoenix; Rajai Al-Jehani; John P Alao; Roger White; Karin B Kindle; Régine Losson; Pierre Chambon; Malcolm G Parker; Primo Schär; David M Heery; Lakjaya Buluwela; Simak Ali
T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif.
Nucleic acids research 2005;33(19):6393-404.
2004: Konstantin Khetchoumian; Marius Teletin; Manuel Mark; Thierry Lerouge; Margarita Cerviño; Mustapha Oulad-Abdelghani; Pierre Chambon; Régine Losson
TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.
The Journal of biological chemistry 2004;279(46):48329-41.
2004: Florence Cammas; Marielle Herzog; Thierry Lerouge; Pierre Chambon; Régine Losson
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation.
Genes & development 2004;18(17):2147-60.
2004: Kai-Ping Yan; Pascal Dollé; Manuel Mark; Thierry Lerouge; Olivia Wendling; Pierre Chambon; Régine Losson
Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene.
Gene 2004;334():3-13.
2004: Anders Lade Nielsen; Poul Jørgensen; Thierry Lerouge; Margarita Cerviño; Pierre Chambon; Régine Losson
Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif.
Molecular and cellular biology 2004;24(12):5184-96.
2004: Julie Gates; Geanette Lam; José A Ortiz; Régine Losson; Carl S Thummel
rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.
Development (Cambridge, England) 2004;131(1):25-36.
2003: Dongsheng Chen; Marie J Lucey; Fladia Phoenix; Jorge Lopez-Garcia; Stephen M Hart; Régine Losson; Lakjaya Buluwela; R Charles Coombes; Pierre Chambon; Primo Schär; Simak Ali
T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha.
The Journal of biological chemistry 2003;278(40):38586-92.
2003: Geetha Vani Rayasam; Olivia Wendling; Pierre-Olivier Angrand; Manuel Mark; Karen Niederreither; Luyan Song; Thierry Lerouge; Gordon L Hager; Pierre Chambon; Régine Losson
NSD1 is essential for early post-implantation development and has a catalytically active SET domain.
The EMBO journal 2003;22(12):3153-63.
2002: Anders Lade Nielsen; Cecilia Sanchez; Hiroshi Ichinose; Margarita Cerviño; Thierry Lerouge; Pierre Chambon; Régine Losson
Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha.
The EMBO journal 2002;21(21):5797-806.
2002: Florence Cammas; Mustapha Oulad-Abdelghani; Jean-Luc Vonesch; Yolande Huss-Garcia; Pierre Chambon; Régine Losson
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction.
Journal of cell science 2002;115(Pt 17):3439-48.
2002: Arndt Benecke; Claudine Gaudon; Jean-Marie Garnier; Elmar vom Baur; Pierre Chambon; Régine Losson
ADA3-containing complexes associate with estrogen receptor alpha.
Nucleic acids research 2002;30(11):2508-14.
2002: Philipp Weber; Florence Cammas; Christelle Gerard; Daniel Metzger; Pierre Chambon; Régine Losson; Manuel Mark
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse.
Development (Cambridge, England) 2002;129(10):2329-37.
2001: Pierre-Olivier Angrand; F Apiou; A Francis Stewart; B Dutrillaux; Régine Losson; Pierre Chambon
NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.
Genomics 2001;74(1):79-88.
2001: RB Beckstead; José A Ortiz; C Sanchez; SN Prokopenko; Pierre Chambon; Régine Losson; Hugo J Bellen
Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription.
Molecular cell 2001;7(4):753-65.
2001: Anders Lade Nielsen; Mustapha Oulad-Abdelghani; José A Ortiz; Eumorphia Remboutsika; Pierre Chambon; Régine Losson
Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.
Molecular cell 2001;7(4):729-39.
2001: Magnus Abrink; J A Ortiz; Charlotta Mark; C Sanchez; Camilla Looman; Lars Hellman; P Chambon; Régine Losson
Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1422-6.
2001: B Le Douarin; David M Heery; Claudine Gaudon; Elmar vom Baur; Régine Losson
Yeast two-hybrid screening for proteins that interact with nuclear hormone receptors.
Methods in molecular biology (Clifton, N.J.) 2001;176():227-48.
2000: Florence Cammas; J Garnier; Pierre Chambon; Régine Losson
Correlation of the exon/intron organization to the conserved domains of the mouse transcriptional corepressor TIF1beta.
Gene 2000;253(2):231-5.
2000: Florence Cammas; Manuel Mark; Pascal Dollé; Andrée Dierich; Pierre Chambon; Régine Losson
Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.
Development (Cambridge, England) 2000;127(13):2955-63.
1999: Anders Lade Nielsen; José A Ortiz; J You; Mustapha Oulad-Abdelghani; R Khechumian; Anne Gansmuller; Pierre Chambon; Régine Losson
Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.
The EMBO journal 1999;18(22):6385-95.
1999: Karen Niederreither; Eumorphia Remboutsika; Anne Gansmuller; Régine Losson; Pascal Dollé
Expression of the transcriptional intermediary factor TIF1alpha during mouse development and in the reproductive organs.
Mechanisms of development 1999;88(1):111-7.
1999: M Géhin; Valerie Vivat Hannah; Jean-Marie Wurtz; Régine Losson; Pierre Chambon; Dino Moras; Hinrich Gronemeyer
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Chemistry & biology 1999;6(8):519-29.
1999: Eumorphia Remboutsika; Yves Lutz; Anne Gansmuller; Jean-Luc Vonesch; Régine Losson; Pierre Chambon
The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin.
Journal of cell science 1999;112 ( Pt 11)():1671-83.
1999: Claudine Gaudon; Pierre Chambon; Régine Losson
Role of the essential yeast protein PSU1 in p6anscriptional enhancement by the ligand-dependent activation function AF-2 of nuclear receptors.
The EMBO journal 1999;18(8):2229-40.
1998: S Um; Matthias Harbers; Arndt Benecke; Benoit Pierrat; Régine Losson; Pierre Chambon
Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase.
The Journal of biological chemistry 1998;273(33):20728-36.
1998: RA Fraser; David Heard; S Adam; Anne-Claire Lavigne; B Le Douarin; Làszlò Tora; Régine Losson; Cécile Rochette-Egly; Pierre Chambon
The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors.
The Journal of biological chemistry 1998;273(26):16199-204.
1998: N Huang; Elmar vom Baur; Jean-Marie Garnier; Thierry Lerouge; Jean-Luc Vonesch; Yves Lutz; Pierre Chambon; Régine Losson
Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators.
The EMBO journal 1998;17(12):3398-412.
1998: Elmar vom Baur; Matthias Harbers; S J Um; Arndt Benecke; Pierre Chambon; Régine Losson
The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors.
Genes & development 1998;12(9):1278-89.
1998: B Le Douarin; J You; Anders Lade Nielsen; Pierre Chambon; Régine Losson
TIF1alpha: a possible link between KRAB zinc finger proteins and nuclear receptors.
The Journal of steroid biochemistry and molecular biology 1998;65(1-6):43-50.
1997: B Le Douarin; Anders Lade Nielsen; J You; Pierre Chambon; Régine Losson
TIF1 alpha: a chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors?
Biochemical Society transactions 1997;25(2):605-12.
1997: F Jeanmougin; Jean-Marie Wurtz; B Le Douarin; P Chambon; Régine Losson
The bromodomain revisited.
Trends in biochemical sciences 1997;22(5):151-3.
1997: H Ichinose; Jean-Marie Garnier; Pierre Chambon; Régine Losson
Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2.
Gene 1997;188(1):95-100.
1996: B Le Douarin; Anders Lade Nielsen; Jean-Marie Garnier; H Ichinose; F Jeanmougin; Régine Losson; Pierre Chambon
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
The EMBO journal 1996;15(23):6701-15.
1996: B Le Douarin; Elmar vom Baur; C Zechel; D Heery; M Heine; Valerie Vivat Hannah; Hinrich Gronemeyer; Régine Losson; Pierre Chambon
Ligand-dependent interaction of nuclear receptors with potential transcriptional intermediary factors (mediators).
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1339):569-78.
1996: Elmar vom Baur; C Zechel; D Heery; M J Heine; Jean-Marie Garnier; Valerie Vivat Hannah; B Le Douarin; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.
The EMBO journal 1996;15(1):110-24.
1995: B Le Douarin; C Zechel; Jean-Marie Garnier; Yves Lutz; Làszlò Tora; P Pierrat; D Heery; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
The EMBO journal 1995;14(9):2020-33.
1995: B Le Douarin; Benoit Pierrat; Elmar vom Baur; Pierre Chambon; Régine Losson
A new version of the two-hybrid assay for detection of protein-protein interactions.
Nucleic acids research 1995;23(5):876-8.
1994: B Durand; M Saunders; C Gaudon; B Roy; Régine Losson; Pierre Chambon
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.
The EMBO journal 1994;13(22):5370-82.
1994: Benoit Pierrat; D M Heery; Pierre Chambon; Régine Losson
A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast.
Gene 1994;143(2):193-200.
1994: D M Heery; Benoit Pierrat; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Homo- and heterodimers of the retinoid X receptor (RXR) activated transcription in yeast.
Nucleic acids research 1994;22(5):726-31.
1993: Benoit Pierrat; François Lacroute; Régine Losson
The 5' untranslated region of the PPR1 regulatory gene dictates rapid mRNA decay in yeast.
Gene 1993;131(1):43-51.
1993: D M Heery; Timothy R Zacharewski; Benoit Pierrat; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4281-5.
1993: David M Gilbert; D M Heery; Régine Losson; Pierre Chambon; Yves LEMOINE
Estradiol-inducible squelching and cell growth arrest by a chimeric VP16-estrogen receptor expressed in Saccharomyces cerevisiae: suppression by an allele of PDR1.
Molecular and cellular biology 1993;13(1):462-72.
1992: Benoit Pierrat; D M Heery; Yves LEMOINE; Régine Losson
Functional analysis of the human estrogen receptor using a phenotypic transactivation assay in yeast.
Gene 1992;119(2):237-45.
1992: David M Gilbert; Régine Losson; Pierre Chambon
Ligand dependence of estrogen receptor induced changes in chromatin structure.
Nucleic acids research 1992;20(17):4525-31.
1992: Daniel Metzger; Régine Losson; J M Bornert; Yves LEMOINE; Pierre Chambon
Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast.
Nucleic acids research 1992;20(11):2813-7.
1985: Régine Losson; Robert Fuchs; François Lacroute
Yeast promoters URA1 and URA3. Examples of positive control.
Journal of molecular biology 1985;185(1):65-81.
1984: P Liljelund; Régine Losson; B Kammerer; François Lacroute
Yeast regulatory gene PPR1. II. Chromosomal localization, meiotic map, suppressibility, dominance/recessivity and dosage effect.
Journal of molecular biology 1984;180(2):251-65.
1983: Régine Losson; François Lacroute
Plasmids carrying the yeast OMP decarboxylase structural and regulatory genes: transcription regulation in a foreign environment.
Cell 1983;32(2):371-7.
1983: Régine Losson; Robert Fuchs; François Lacroute
In vivo transcription of a eukaryotic regulatory gene.
The EMBO journal 1983;2(12):2179-84.
1981: Régine Losson; François Lacroute
Cloning of a eukaryotic regulatory gene.
Molecular & general genetics : MGG 1981;184(3):394-9.