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Reuben Lotan

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
84
Hong, Waun Ki
50
Lippman, Scott
31
Xu, Xiao-Chun
30
Lee, Jack
29
Lotan, Dafna
21
Sun, Shi-Yong
19
Yue, Ping
17
Hittelman, Walter
16
Lee, Jin
14
Mao, Li
14
Khuri, Fadlo
13
El-Naggar, Adel
12
Oridate, Nobuhiko
10
Hail, Numsen
9
Clayman, Gary

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Publications

TOP 3
Kadara Humam; Lacroix Ludovic; Behrens Carmen; Solis Luisa; Gu Xuemin; Lee J Jack; Tahara Eiji; Lotan Dafna; Hong Waun Ki; Wistuba Ignacio I; Lotan Reuben
Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.
Wu Xifeng; Spitz Margaret R; Lee J Jack; Lippman Scott M; Ye Yuanqing; Yang Hushan; Khuri Fadlo R; Kim Edward; Gu Jian; Lotan Reuben; Hong Waun K
Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.
Brannan Jennifer M; Dong Wenli; Prudkin Ludmila; Behrens Carmen; Lotan Reuben; Bekele B Nebiyou; Wistuba Ignacio; Johnson Faye M
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.

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All Publications

2009: Kadara Humam; Lacroix Ludovic; Behrens Carmen; Solis Luisa; Gu Xuemin; Lee J Jack; Tahara Eiji; Lotan Dafna; Hong Waun Ki; Wistuba Ignacio I; Lotan Reuben
Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.
Cancer prevention research (Philadelphia, Pa.) 2009;2(8):702-11.
2009: Wu Xifeng; Spitz Margaret R; Lee J Jack; Lippman Scott M; Ye Yuanqing; Yang Hushan; Khuri Fadlo R; Kim Edward; Gu Jian; Lotan Reuben; Hong Waun K
Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.
Cancer prevention research (Philadelphia, Pa.) 2009;2(7):617-24.
2009: Brannan Jennifer M; Dong Wenli; Prudkin Ludmila; Behrens Carmen; Lotan Reuben; Bekele B Nebiyou; Wistuba Ignacio; Johnson Faye M
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4423-30.
2009: Tahara Eiji; Kadara Humam; Lacroix Ludovic; Lotan Dafna; Lotan Reuben
Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction.
Cancer biology & therapy 2009;8(9):801-7.
2009: Ye Xiaofeng; Tao Qingguo; Wang Yafan; Cheng Yijun; Lotan Reuben
Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid.
Cancer biology & therapy 2009;8(10):951-62.
2009: Zinner Ralph G; Barrett Brittany L; Popova Elmira; Damien Paul; Volgin Andrei Y; Gelovani Juri G; Lotan Reuben; Tran Hai T; Pisano Claudio; Mills Gordon B; Mao Li; Hong Waun K; Lippman Scott M; Miller John H
Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
Molecular cancer therapeutics 2009;8(3):521-32.
2009: Song Shumei; Guan Baoxiang; Men Taoyan; Hoque Ashraful; Lotan Reuben; Xu Xiao-Chun
Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2.
Cancer prevention research (Philadelphia, Pa.) 2009;2(3):274-80.
2009: William William N; Lee J Jack; Lippman Scott M; Martin Jack W; Chakravarti Nitin; Tran Hai T; Sabichi Anita L; Kim Edward S; Feng Lei; Lotan Reuben; Papadimitrakopoulou Vassiliki A
High-dose fenretinide in oral leukoplakia.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):22-6.
2009: Hail Numsen; Lotan Reuben
Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state.
Molecular nutrition & food research 2009;53(1):49-67.
2008: Behrens Carmen; Lin Heather Y; Lee J Jack; Raso Maria Gabriela; Hong Waun Ki; Wistuba Ignacio I; Lotan Reuben
Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):6014-22.
2008: Ye Xiaofeng; Lotan Reuben
Potential misinterpretation of data on differential gene expression in normal and malignant cells in vitro.
Briefings in functional genomics & proteomics 2008;7(4):322-6.
2008: Kadara Humam; Tahara Eiji; Kim Hyun-Jung; Lotan Dafna; Myers Jeffrey; Lotan Reuben
Involvement of Rac in fenretinide-induced apoptosis.
Cancer research 2008;68(11):4416-23.
2007: Gillenwater Ann M; Zhong Meiling; Lotan Reuben
Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells.
Molecular cancer therapeutics 2007;6(11):2967-75.
2007: Tao Qingguo; Fujimoto Junya; Men Taoyan; Ye Xiaofeng; Deng Jiong; Lacroix Ludovic; Clifford John L; Mao Li; Van Pelt Carolyn S; Lee J Jack; Lotan Dafna; Lotan Reuben
Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene.
Journal of the National Cancer Institute 2007;99(22):1668-82.
2007: Hittelman Walter N; Liu Diane D; Kurie Jonathan M; Lotan Reuben; Lee Jin Soo; Khuri Fadlo; Ibarguen Heladio; Morice Rodolfo C; Walsh Garrett; Roth Jack A; Minna John; Ro Jae Y; Broxson Anita; Hong Waun Ki; Lee J Jack
Proliferative changes in the bronchial epithelium of former smokers treated with retinoids.
Journal of the National Cancer Institute 2007;99(21):1603-12.
2007: Chakravarti Nitin; Lotan Reuben; Diwan Abdul H; Warneke Carla L; Johnson Marcella M; Prieto Victor G
Decreased expression of retinoid receptors in melanoma: entailment in tumorigenesis and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(16):4817-24.
2007: Kim Seung-Wook; Cheon Kyounga; Kim Chang-Hoon; Yoon Joo-Heon; Hawke David H; Kobayashi Ryuji; Prudkin Ludmila; Wistuba Ignacio I; Lotan Reuben; Hong Waun Ki; Koo Ja Seok
Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method.
Cancer research 2007;67(14):6565-73.
2007: Kadara Humam; Lacroix Ludovic; Lotan Dafna; Lotan Reuben
Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells.
Cancer biology & therapy 2007;6(5):705-11.
2007: Schroeder Claudia P; Yang Peiying; Newman Robert A; Lotan Reuben
Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines.
Journal of experimental therapeutics & oncology 2007;6(3):183-92.
2006: Williams Michelle D; Chakravarti Nitin; Kies Merrill S; Maruya Shin-ichiro; Myers Jeffrey N; Haviland Joie C; Weber Randal S; Lotan Reuben; El-Naggar Adel K
Implications of methylation patterns of cancer genes in salivary gland tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7353-8.
2006: Shen Jie; Behrens Carmen; Wistuba Ignacio I; Feng Lei; Lee J Jack; Hong Waun Ki; Lotan Reuben
Identification and validation of differences in protein levels in normal, premalignant, and malignant lung cells and tissues using high-throughput Western Array and immunohistochemistry.
Cancer research 2006;66(23):11194-206.
2006: Schroeder Claudia P; Kadara Humam; Lotan Dafna; Woo Jong K; Lee Ho-Young; Hong Waun Ki; Lotan Reuben
Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells.
Cancer research 2006;66(19):9762-70.
2006: Hail N; Kim H J; Lotan R
Mechanisms of fenretinide-induced apoptosis.
Apoptosis : an international journal on programmed cell death 2006;11(10):1677-94.
2006: Liang Zheng D; Lippman Scott M; Wu Tsung-Teh; Lotan Reuben; Xu Xiao-Chun
RRIG1 mediates effects of retinoic acid receptor beta2 on tumor cell growth and gene expression through binding to and inhibition of RhoA.
Cancer research 2006;66(14):7111-8.
2006: Lacroix Ludovic; Feng Gang; Lotan Reuben
Identification of genes expressed differentially in an in vitro human lung carcinogenesis model.
Cancer biology & therapy 2006;5(6):665-73.
2006: Lippman Scott M; Lee J Jack; Martin Jack W; El-Naggar Adel K; Xu Xiaochun; Shin Dong M; Thomas Margaret; Mao Li; Fritsche Herbert A; Zhou Xian; Papadimitrakopoulou Vassiliki; Khuri Fadlo R; Tran Hai; Clayman Gary L; Hittelman Walter N; Hong Waun Ki; Lotan Reuben
Fenretinide activity in retinoid-resistant oral leukoplakia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3109-14.
2006: Kadara Humam; Schroeder Claudia P; Lotan Dafna; Pisano Claudio; Lotan Reuben
Induction of GDF-15/NAG-1/MIC-1 in human lung carcinoma cells by retinoid-related molecules and assessment of its role in apoptosis.
Cancer biology & therapy 2006;5(5):518-22.
2006: Kim H-J; Chakravarti N; Oridate N; Choe C; Claret F-X; Lotan R
N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.
Oncogene 2006;25(19):2785-94.
2006: Chakravarti Nitin; El-Naggar Adel K; Lotan Reuben; Anderson James; Diwan Abdul H; Saadati Hossein G; Diba Roxana; Prieto Victor G; Esmaeli Bita
Expression of retinoid receptors in sebaceous cell carcinoma.
Journal of cutaneous pathology 2006;33(1):10-7.
2005: Shishodia Shishir; Gutierrez Angelica M; Lotan Reuben; Aggarwal Bharat B
N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
Cancer research 2005;65(20):9555-65.
2005: Kim Hyun-Jung; Oridate Nobuhiko; Lotan Reuben
Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.
International journal of oncology 2005;27(3):787-90.
2005: Ju Z; Kapoor M; Newton K; Cheon K; Ramaswamy A; Lotan R; Strong L C; Koo J S
Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells.
Molecular genetics and genomics : MGG 2005;274(2):141-54.
2005: Chakravarti Nitin; Saadati Hossein G; El-Naggar Adel K; Lotan Reuben; Diba Roxanna E; Esmaeli Bita
Retinoid receptor subtypes in sebaceous cell carcinoma of the eyelid.
Ophthalmic plastic and reconstructive surgery 2005;21(4):292-7.
2005: Lee Ho-Young; Chang Yoon Soo; Han Ji-Youn; Liu Diane D; Lee J Jack; Lotan Reuben; Spitz Margaret R; Hong Waun Ki
Effects of 9-cis-retinoic acid on the insulin-like growth factor axis in former smokers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(19):4439-49.
2005: Maruya S I; Myers J N; Weber R S; Rosenthal D I; Lotan R; El-Naggar A K
ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!
Oral oncology 2005;41(6):580-8.
2005: Chun Kyung-Hee; Pfahl Magnus; Lotan Reuben
Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells.
Oncogene 2005;24(22):3669-77.
2005: Sun Shi-Yong; Schroeder Claudia P; Yue Ping; Lotan Dafna; Hong Waun K; Lotan Reuben
Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations.
Cancer biology & therapy 2005;4(4):407-13.
2005: Oridate Nobuhiko; Kim Hyun-Jung; Xu Xiaochun; Lotan Reuben
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
Cancer biology & therapy 2005;4(3):318-23.
2005: Han Ji-Youn; Liu Diane D; Lee J Jack; Kurie Jonathan; Lotan Reuben; Hong Waun K; Lee Ho-Young
9-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(6):2305-11.
2005: Oridate Nobuhiko; Lotan Reuben
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
International journal of oncology 2005;26(3):757-61.
2005: Kim Hyun-Jung; Lotan Reuben
Identification of protein modulation by the synthetic retinoid CD437 in lung carcinoma cells using high throughput immunoblotting.
International journal of oncology 2005;26(2):483-91.
2005: Zou Changping; Ramakumar Sanjay; Qian Lixin; Zou Changchun; Zang Rongyu; Wang Jian; Grossman H Barton; Lotan Reuben; Liebert Monica
Effect of retinoic acid and interferon alpha-2a on transitional cell carcinoma of bladder.
The Journal of urology 2005;173(1):247-51.
2004: Hsi Linda C; Xi Xiaopei; Lotan Reuben; Shureiqi Imad; Lippman Scott M
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Cancer research 2004;64(23):8778-81.
2004: Lu Charles; Soria Jean-Charles; Tang Ximing; Xu Xiao-Chun; Wang Luo; Mao Li; Lotan Reuben; Kemp Bonnie; Bekele B Nebiyou; Feng Lei; Hong Waun K; Khuri Fadlo R
Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(22):4575-83.
2004: Lee Ho-Young; Moon Hojin; Chun Kyung-Hee; Chang Yoon-Soo; Hassan Khaled; Ji Lin; Lotan Reuben; Khuri Fadlo R; Hong Waun Ki
Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells.
Journal of the National Cancer Institute 2004;96(20):1536-48.
2004: Youssef Emile M; Issa Jean-Pierre J; Lotan Reuben
Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling.
Cancer biology & therapy 2004;3(10):1002-6.
2004: Schroeder Claudia P; Yang Peiying; Newman Robert A; Lotan Reuben
Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib.
Cancer biology & therapy 2004;3(9):847-52.
2004: Hail N; Lotan R
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.
Apoptosis : an international journal on programmed cell death 2004;9(4):437-47.
2004: Maruya Shin-ichiro; Issa Jean-Pierre J; Weber Randal S; Rosenthal David I; Haviland Joie C; Lotan Reuben; El-Naggar Adel K
Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3825-30.
2004: Choi Jin-Hyuk; Chun Kyung-Hee; Raz Avraham; Lotan Reuben
Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3.
Cancer biology & therapy 2004;3(5):447-52.
2004: Sun Shi-Yong; Hail Numsen; Lotan Reuben
Apoptosis as a novel target for cancer chemoprevention.
Journal of the National Cancer Institute 2004;96(9):662-72.
2004: Kim Hyun-Jung; Lotan Reuben
Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting.
Cancer research 2004;64(7):2439-48.
2004: Youssef Emile M; Chen Xu-qi; Higuchi Eisaku; Kondo Yutaka; Garcia-Manero Guillermo; Lotan Reuben; Issa Jean-Pierre J
Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers.
Cancer research 2004;64(7):2411-7.
2004: Alberts David; Ranger-Moore James; Einspahr Janine; Saboda Kathylynn; Bozzo Paul; Liu Yun; Xu Xiao-Chun; Lotan Reuben; Warneke James; Salasche Stuart; Stratton Suzanne; Levine Norman; Goldman Rayna; Islas Marcy; Duckett Laura; Thompson Deborah; Bartels Peter; Foote Janet
Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):1875-80.
2004: Youssef Emile M; Lotan Dafna; Issa Jean-Pierre; Wakasa Kenichi; Fan You-Hong; Mao Li; Hassan Khaled; Feng Lei; Lee J Jack; Lippman Scott M; Hong Waun K; Lotan Reuben
Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1733-42.
2004: Hail Numsen; Konopleva Marina; Sporn Michael; Lotan Reuben; Andreeff Michael
Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).
The Journal of biological chemistry 2004;279(12):11179-87.
2004: Tao Qingguo; Cheng Yijun; Clifford John; Lotan Reuben
Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid.
Genomics 2004;83(2):270-80.
2004: Yang Zhibo; Bagheri-Yarmand Rozita; Wang Rui-An; Adam Liana; Papadimitrakopoulou Vali Vassiliki; Clayman Gary L; El-Naggar Adel; Lotan Reuben; Barnes Christopher J; Hong Waun Ki; Kumar Rakesh
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):658-67.
2003: Sabichi Anita L; Xu Hui; Fischer Susan; Zou Changchan; Yang Xiulan; Steele Vernon E; Kelloff Gary J; Lotan Reuben; Clifford John L
Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(12):4606-13.
2003: Chun Kyung-Hee; Lee Ho-Young; Hassan Khaled; Khuri Fadlo; Hong Waun Ki; Lotan Reuben
Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells.
Cancer research 2003;63(16):4796-800.
2003: Higuchi Eisaku; Chandraratna Roshantha A S; Hong Waun K; Lotan Reuben
Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype.
Oncogene 2003;22(30):4627-35.
2003: Chun Kyung-Hee; Benbrook Doris M; Berlin K Darrell; Hong Waun Ki; Lotan Reuben
The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway.
Cancer research 2003;63(13):3826-32.
2003: Sokolov Konstantin; Follen Michele; Aaron Jesse; Pavlova Ina; Malpica Anais; Lotan Reuben; Richards-Kortum Rebecca
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.
Cancer research 2003;63(9):1999-2004.
2003: Huh Julie J; Wolf Judith K; Fightmaster Diane L; Lotan Reuben; Follen Michele
Transduction of adenovirus-mediated wild-type p53 after radiotherapy in human cervical cancer cells.
Gynecologic oncology 2003;89(2):243-50.
2003: Faderl Stefan; Lotan Reuben; Kantarjian Hagop M; Harris David; Van Quin; Estrov Zeev
N-(4-Hydroxylphenyl)retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL).
Leukemia research 2003;27(3):259-66.
2003: Chun Kyung-Hee; Kosmeder Jerome W; Sun Shihua; Pezzuto John M; Lotan Reuben; Hong Waun Ki; Lee Ho-Young
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Journal of the National Cancer Institute 2003;95(4):291-302.
2003: Kurie Jonathan M; Lotan Reuben; Lee J Jack; Lee Jin Soo; Morice Rodolfo C; Liu Diane D; Xu Xiao-Chun; Khuri Fadlo R; Ro Jae Y; Hittelman Walter N; Walsh Garrett L; Roth Jack A; Minna John D; Hong Waun Ki
Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial.
Journal of the National Cancer Institute 2003;95(3):206-14.
2003: Lotan R
Receptor-independent induction of apoptosis by synthetic retinoids.
Journal of biological regulators and homeostatic agents 2003;17(1):13-28.
2003: Soria Jean-Charles; Xu Xiaochun; Liu Diane D; Lee J Jack; Kurie Jonathan; Morice Rodolfo C; Khuri Fadlo; Mao Li; Hong Waun K; Lotan Reuben
Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers.
Journal of the National Cancer Institute 2003;95(2):165-8.
2002: Singletary S Eva; Atkinson Edward N; Hoque Ashraful; Sneige Nour; Sahin Ayse A; Fritsche Herbert A; Lotan Reuben; Lu Tao; Hittelman Walter N; Bevers Therese B; Stelling Carol B; Lippman Scott M
Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(9):2835-42.
2002: Hail Numsen; Lotan Reuben
Examining the role of mitochondrial respiration in vanilloid-induced apoptosis.
Journal of the National Cancer Institute 2002;94(17):1281-92.
2002: Zuluaga Andrés F; Drezek Rebekah; Collier Tom; Lotan Reuben; Follen Michele; Richards-Kortum Rebecca
Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspension.
Journal of biomedical optics 2002;7(3):398-403.
2002: Clifford John L; Walch Eugene; Yang Xiulan; Xu Xiaochun; Alberts David S; Clayman Gary L; El-Naggar Adel K; Lotan Reuben; Lippman Scott M
Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2067-72.
2002: Guan Baoxiang; Yue Ping; Lotan Reuben; Sun Shi-Yong
Evidence that the human death receptor 4 is regulated by activator protein 1.
Oncogene 2002;21(20):3121-9.
2002: Sun Shi-Yong; Yue Ping; Chen Xueyun; Hong Waun K; Lotan Reuben
The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.
Cancer research 2002;62(8):2430-6.
2002: Shureiqi Imad; Jiang Wei; Fischer Susan M; Xu Xiaochun; Chen Dongning; Lee J Jack; Lotan Reuben; Lippman Scott M
GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells.
Cancer research 2002;62(4):1178-83.
2002: Kim Kevin B; Lotan Reuben; Yue Ping; Sporn Michael B; Suh Nanjoo; Gribble Gordon W; Honda Tadashi; Wu Gen Sheng; Hong Waun Ki; Sun Shi-Yong
Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.
Molecular cancer therapeutics 2002;1(3):177-84.
2002: Li Ming; Song Shumei; Lippman Scott M; Zhang Xiao-kun; Liu Xiaoming; Lotan Reuben; Xu Xiao-Chun
Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells.
Oncogene 2002;21(3):411-8.
2002: Sun Shi-Yong; Lotan Reuben
Retinoids and their receptors in cancer development and chemoprevention.
Critical reviews in oncology/hematology 2002;41(1):41-55.
2002: Shin Dong M; Glisson Bonnie S; Khuri Fadlo R; Clifford John L; Clayman Gary; Benner Steven E; Forastiere Arlene A; Ginsberg Lawrence; Liu Diane; Lee J Jack; Myers Jeffrey; Goepfert Helmuth; Lotan Reuben; Hong Waun Ki; Lippman Scott M
Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(2):364-70.
2002: Wu Weiguo; Tang Ximing; Hu Wei; Lotan Reuben; Hong Waun Ki; Mao Li
Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry.
Clinical & experimental metastasis 2002;19(4):319-26.
2001: Hail N; Lotan R
Mitochondrial respiration is uniquely associated with the prooxidant and apoptotic effects of N-(4-hydroxyphenyl)retinamide.
The Journal of biological chemistry 2001;276(49):45614-21.
2001: Follen M; Atkinson E N; Schottenfeld D; Malpica A; West L; Lippman S; Zou C; Hittelman W N; Lotan R; Hong W K
A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3356-65.
2001: Feng G; Xu X; Youssef E M; Lotan R
Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis.
Cancer research 2001;61(21):7999-8004.
2001: Zou C P; Youssef E M; Zou C C; Carey T E; Lotan R
Differential effects of chromosome 3p deletion on the expression of the putative tumor suppressor RAR beta and on retinoid resistance in human squamous carcinoma cells.
Oncogene 2001;20(47):6820-7.
2001: Hail N; Youssef E M; Lotan R
Evidence supporting a role for mitochondrial respiration in apoptosis induction by the synthetic retinoid CD437.
Cancer research 2001;61(18):6698-702.
2001: Drezek R; Brookner C; Pavlova I; Boiko I; Malpica A; Lotan R; Follen M; Richards-Kortum R
Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with dysplasia.
Photochemistry and photobiology 2001;73(6):636-41.
2001: Shureiqi I; Xu X; Chen D; Lotan R; Morris J S; Fischer S M; Lippman S M
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Cancer research 2001;61(12):4879-84.
2001: Sun S Y; Yue P; Kelloff G J; Steele V E; Lippman S M; Hong W K; Lotan R
Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(6):595-601.
2001: Xu X C; Wong W Y; Goldberg L; Baer S C; Wolf J E; Ramsdell W M; Alberts D S; Lippman S M; Lotan R
Progressive decreases in nuclear retinoid receptors during skin squamous carcinogenesis.
Cancer research 2001;61(11):4306-10.
2001: Clifford J L; Sabichi A L; Zou C; Yang X; Steele V E; Kelloff G J; Lotan R; Lippman S M
Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(4):391-5.
2001: Lippman S M; Lee J J; Karp D D; Vokes E E; Benner S E; Goodman G E; Khuri F R; Marks R; Winn R J; Fry W; Graziano S L; Gandara D R; Okawara G; Woodhouse C L; Williams B; Perez C; Kim H W; Lotan R; Roth J A; Hong W K
Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer.
Journal of the National Cancer Institute 2001;93(8):605-18.
2001: Khuri F R; Wu H; Lee J J; Kemp B L; Lotan R; Lippman S M; Feng L; Hong W K; Xu X C
Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):861-7.
2001: Zou C; Liebert M; Zou C; Grossman H B; Lotan R
Identification of effective retinoids for inhibiting growth and inducing apoptosis in bladder cancer cells.
The Journal of urology 2001;165(3):986-92.
2001: Wan H; Hong W K; Lotan R
Increased retinoic acid responsiveness in lung carcinoma cells that are nonresponsive despite the presence of endogenous retinoic acid receptor (RAR) beta by expression of exogenous retinoid receptors retinoid X receptor alpha, RAR alpha, and RAR gamma.
Cancer research 2001;61(2):556-64.
2001: Sun S Y; Yue P; Zhou J Y; Wang Y; Choi Kim H R; Lotan R; Wu G S
Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells.
Biochemical and biophysical research communications 2001;280(3):788-97.
2001: Hail N; Lotan R
Synthetic retinoid CD437 promotes rapid apoptosis in malignant human epidermal keratinocytes and G1 arrest in their normal counterparts.
Journal of cellular physiology 2001;186(1):24-34.
2000: Sun S Y; Yue P; Hong W K; Lotan R
Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells.
Cancer research 2000;60(24):7149-55.
2000: Shureiqi I; Chen D; Lotan R; Yang P; Newman R A; Fischer S M; Lippman S M
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Cancer research 2000;60(24):6846-50.
2000: Hail N; Lotan R
Mitochondrial permeability transition is a central coordinating event in N-(4-hydroxyphenyl)retinamide-induced apoptosis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(12):1293-301.
2000: Sun S Y; Yue P; Hong W K; Lotan R
Induction of Fas expression and augmentation of Fas/Fas ligand-mediated apoptosis by the synthetic retinoid CD437 in human lung cancer cells.
Cancer research 2000;60(22):6537-43.
2000: Clifford J L; Menter D G; Yang X; Walch E; Zou C; Clayman G L; Schaefer T S; El-Naggar A K; Lotan R; Lippman S M
Expression of protein mediators of type I interferon signaling in human squamous cell carcinoma of the skin.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(9):993-7.
2000: Sun S Y; Yue P; Lotan R
Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells.
Oncogene 2000;19(39):4513-22.
2000: Sun S Y; Yue P; Chandraratna R A; Tesfaigzi Y; Hong W K; Lotan R
Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells.
Molecular pharmacology 2000;58(3):508-14.
2000: Kurie J M; Lee J S; Khuri F R; Mao L; Morice R C; Lee J J; Walsh G L; Broxson A; Lippman S M; Ro J Y; Kemp B L; Liu D; Fritsche H A; Xu X; Lotan R; Hong W K
N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):2973-9.
2000: Khuri F R; Lotan R; Kemp B L; Lippman S M; Wu H; Feng L; Lee J J; Cooksley C S; Parr B; Chang E; Walsh G L; Lee J S; Hong W K; Xu X C
Retinoic acid receptor-beta as a prognostic indicator in stage I non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(15):2798-804.
2000: Xu X C; Sola Gallego J J; Lotan R; El-Naggar A K
Differential expression of galectin-1 and galectin-3 in benign and malignant salivary gland neoplasms.
International journal of oncology 2000;17(2):271-6.
2000: Shureiqi I; Chen D; Lee J J; Yang P; Newman R A; Brenner D E; Lotan R; Fischer S M; Lippman S M
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Journal of the National Cancer Institute 2000;92(14):1136-42.
2000: Li M; Lotan R; Levin B; Tahara E; Lippman S M; Xu X C
Aspirin induction of apoptosis in esophageal cancer: a potential for chemoprevention.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(6):545-9.
2000: Brookner C K; Follen M; Boiko I; Galvan J; Thomsen S; Malpica A; Suzuki S; Lotan R; Richards-Kortum R
Autofluorescence patterns in short-term cultures of normal cervical tissue.
Photochemistry and photobiology 2000;71(6):730-6.
2000: Qiu H; Lotan R; Lippman S M; Xu X C
Lack of correlation between expression of retinoic acid receptor-beta and loss of heterozygosity on chromosome band 3p24 in esophageal cancer.
Genes, chromosomes & cancer 2000;28(2):196-202.
2000: Sun S Y; Wan H; Yue P; Hong W K; Lotan R
Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition.
The Journal of biological chemistry 2000;275(22):17149-53.
2000: Drezek R A; Collier T; Brookner C K; Malpica A; Lotan R; Richards-Kortum R R; Follen M
Laser scanning confocal microscopy of cervical tissue before and after application of acetic acid.
American journal of obstetrics and gynecology 2000;182(5):1135-9.
2000: Lee J J; Hong W K; Hittelman W N; Mao L; Lotan R; Shin D M; Benner S E; Xu X C; Lee J S; Papadimitrakopoulou V M; Geyer C; Perez C; Martin J W; El-Naggar A K; Lippman S M
Predicting cancer development in oral leukoplakia: ten years of translational research.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1702-10.
2000: Gillenwater A; Zou C P; Zhong M; Lotan R
Effects of sodium butyrate on growth, differentiation, and apoptosis in head and neck squamous carcinoma cell lines.
Head & neck 2000;22(3):247-56.
2000: Sun S Y; Yue P; Mao L; Dawson M I; Shroot B; Lamph W W; Heyman R A; Chandraratna R A; Shudo K; Hong W K; Lotan R
Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1563-73.
2000: Heintzelman D L; Lotan R; Richards-Kortum R R
Characterization of the autofluorescence of polymorphonuclear leukocytes, mononuclear leukocytes and cervical epithelial cancer cells for improved spectroscopic discrimination of inflammation from dysplasia.
Photochemistry and photobiology 2000;71(3):327-32.
2000: Lippman S M; Lotan R
Advances in the development of retinoids as chemopreventive agents.
The Journal of nutrition 2000;130(2S Suppl):479S-482S.
1999: Suzuki S; Higuchi M; Proske R J; Oridate N; Hong W K; Lotan R
Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells.
Oncogene 1999;18(46):6380-7.
1999: Ellerhorst J; Troncoso P; Xu X C; Lee J; Lotan R
Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer.
Urological research 1999;27(5):362-7.
1999: Xu X C; Lee J S; Lee J J; Morice R C; Liu X; Lippman S M; Hong W K; Lotan R
Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention.
Journal of the National Cancer Institute 1999;91(15):1317-21.
1999: Sun S Y; Yue P; Shroot B; Hong W K; Lotan R
Implication of c-Myc in apoptosis induced by the retinoid CD437 in human lung carcinoma cells.
Oncogene 1999;18(26):3894-901.
1999: Wan H; Oridate N; Lotan D; Hong W K; Lotan R
Overexpression of retinoic acid receptor beta in head and neck squamous cell carcinoma cells increases their sensitivity to retinoid-induced suppression of squamous differentiation by retinoids.
Cancer research 1999;59(14):3518-26.
1999: Xu X C; Mitchell M F; Silva E; Jetten A; Lotan R
Decreased expression of retinoic acid receptors, transforming growth factor beta, involucrin, and cornifin in cervical intraepithelial neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1503-8.
1999: Sun S Y; Yue P; Wu G S; El-Deiry W S; Shroot B; Hong W K; Lotan R
Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells.
Cancer research 1999;59(12):2829-33.
1999: Sun S Y; Li W; Yue P; Lippman S M; Hong W K; Lotan R
Mediation of N-(4-hydoxyphenyl)retinamide-induced apoptosis in human cancer cells by different mechanisms.
Cancer research 1999;59(10):2493-8.
1999: Xu X C; Liu X; Tahara E; Lippman S M; Lotan R
Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines.
Cancer research 1999;59(10):2477-83.
1999: Sun S Y; Yue P; Wu G S; El-Deiry W S; Shroot B; Hong W K; Lotan R
Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells.
Oncogene 1999;18(14):2357-65.
1999: Sun S Y; Yue P; Lotan R
Induction of apoptosis by N-(4-hydroxyphenyl)retinamide and its association with reactive oxygen species, nuclear retinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.
Molecular pharmacology 1999;55(3):403-10.
1999: Sun S Y; Kurie J M; Yue P; Dawson M I; Shroot B; Chandraratna R A; Hong W K; Lotan R
Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):431-7.
1999: Ellerhorst J; Nguyen T; Cooper D N; Estrov Y; Lotan D; Lotan R
Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1.
International journal of oncology 1999;14(2):225-32.
1999: Ellerhorst J; Nguyen T; Cooper D N; Lotan D; Lotan R
Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype.
International journal of oncology 1999;14(2):217-24.
1999: Zou C P; Hong W K; Lotan R
Expression of retinoic acid receptor beta is associated with inhibition of keratinization in human head and neck squamous carcinoma cells.
Differentiation; research in biological diversity 1999;64(2):123-32.
1999: Clifford J L; Menter D G; Wang M; Lotan R; Lippman S M
Retinoid receptor-dependent and -independent effects of N-(4-hydroxyphenyl)retinamide in F9 embryonal carcinoma cells.
Cancer research 1999;59(1):14-8.
1998: Cheng Y; Lotan R
Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor.
The Journal of biological chemistry 1998;273(52):35008-15.
1998: Zou C; Wang L; Liebert M; Grossman H B; Lotan R; Wei Q
Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines.
International journal of oncology 1998;13(5):1037-41.
1998: Wan H; Dawson M I; Hong W K; Lotan R
Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cells.
The Journal of biological chemistry 1998;273(41):26915-22.
1998: Zou C P; Kurie J M; Lotan D; Zou C C; Hong W K; Lotan R
Higher potency of N-(4-hydroxyphenyl)retinamide than all-trans-retinoic acid in induction of apoptosis in non-small cell lung cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1345-55.
1998: Mitchell M F; Tortolero-Luna G; Lee J J; Hittelman W N; Lotan R; Wharton J T; Hong W K; Nishioka K
Phase I dose de-escalation trial of alpha-difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(2):303-10.
1998: Gillenwater A; Xu X C; Estrov Y; Sacks P G; Lotan D; Lotan R
Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate.
International journal of cancer. Journal international du cancer 1998;75(2):217-24.
1997: Xu X C; Sneige N; Liu X; Nandagiri R; Lee J J; Lukmanji F; Hortobagyi G; Lippman S M; Dhingra K; Lotan R
Progressive decrease in nuclear retinoic acid receptor beta messenger RNA level during breast carcinogenesis.
Cancer research 1997;57(22):4992-6.
1997: Sun S Y; Yue P; Shroot B; Hong W K; Lotan R
Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437.
Journal of cellular physiology 1997;173(2):279-84.
1997: Sun S Y; Yue P; Dawson M I; Shroot B; Michel S; Lamph W W; Heyman R A; Teng M; Chandraratna R A; Shudo K; Hong W K; Lotan R
Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells.
Cancer research 1997;57(21):4931-9.
1997: Wan H; Dawson M I; Hong W K; Lotan R
Enhancement of Calu-1 human lung carcinoma cell growth in serum-free medium by retinoids: dependence on AP-1 activation, but not on retinoid response element activation.
Oncogene 1997;15(17):2109-18.
1997: Lotan R
Retinoids and chemoprevention of aerodigestive tract cancers.
Cancer metastasis reviews 1997;16(3-4):349-56.
1997: Oridate N; Suzuki S; Higuchi M; Mitchell M F; Hong W K; Lotan R
Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells.
Journal of the National Cancer Institute 1997;89(16):1191-8.
1997: Shin D M; Xu X C; Lippman S M; Lee J J; Lee J S; Batsakis J G; Ro J Y; Martin J W; Hittelman W N; Lotan R; Hong W K
Accumulation of p53 protein and retinoic acid receptor beta in retinoid chemoprevention.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):875-80.
1997: Lotan R
Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers.
Environmental health perspectives 1997;105 Suppl 4():985-8.
1997: Xu X C; Sozzi G; Lee J S; Lee J J; Pastorino U; Pilotti S; Kurie J M; Hong W K; Lotan R
Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development.
Journal of the National Cancer Institute 1997;89(9):624-9.
1997: Papadimitrakopoulou V; Izzo J; Lippman S M; Lee J S; Fan Y H; Clayman G; Ro J Y; Hittelman W N; Lotan R; Hong W K; Mao L
Frequent inactivation of p16INK4a in oral premalignant lesions.
Oncogene 1997;14(15):1799-803.
1997: Oridate N; Higuchi M; Suzuki S; Shroot B; Hong W K; Lotan R
Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl)hydroxyphenyl]-2-naphtalene carboxylic acid (CD437).
International journal of cancer. Journal international du cancer 1997;70(4):484-7.
1997: Lippman S M; Lotan R; Schleuniger U
Retinoid-interferon therapy of solid tumors.
International journal of cancer. Journal international du cancer 1997;70(4):481-3.
1997: Khuri F R; Lippman S M; Spitz M R; Lotan R; Hong W K
Molecular epidemiology and retinoid chemoprevention of head and neck cancer.
Journal of the National Cancer Institute 1997;89(3):199-211.
1997: Mitchell M F; Tortolero-Luna G; Lee J J; Hittelman W K; Lotan R; Wharton J T; Hong W K; Nishioka K
Polyamine measurements in the uterine cervix.
Journal of cellular biochemistry. Supplement 1997;28-29():125-32.
1996: Mao L; El-Naggar A K; Fan Y H; Lee J S; Lippman S M; Kayser S; Lotan R; Hong W K
Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues.
Cancer research 1996;56(24):5600-4.
1996: Eicher S A; Lotan R
Differential effects of retinoic acid and N-(4-hydroxyphenyl)retinamide on head and neck squamous cell carcinoma cells.
The Laryngoscope 1996;106(12 Pt 1):1471-5.
1996: Mao L; Fan Y H; Lotan R; Hong W K
Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines.
Cancer research 1996;56(22):5128-31.
1996: Eicher S A; Clayman G L; Liu T J; Shillitoe E J; Storthz K A; Roth J A; Lotan R
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(10):1659-64.
1996: Sacks P G; Amos B; Lotan R
Enhancement of glycosylation of cellular glycoconjugates in the squamous carcinoma cell line MDA886Ln by beta-all-trans retinoic acid.
Glycoconjugate journal 1996;13(5):791-6.
1996: Gillenwater A; Xu X C; el-Naggar A K; Clayman G L; Lotan R
Expression of galectins in head and neck squamous cell carcinoma.
Head & neck 1996;18(5):422-32.
1996: Lee H Y; Dawson M I; Walsh G L; Nesbitt J C; Eckert R L; Fuchs E; Hong W K; Lotan R; Kurie J M
Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(8):997-1004.
1996: Lotan R
Retinoids and their receptors in modulation of differentiation, development, and prevention of head and neck cancers.
Anticancer research 1996;16(4C):2415-9.
1996: Lotan R
Retinoids in cancer chemoprevention.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(9):1031-9.
1996: Hamada K; Alemany R; Zhang W W; Hittelman W N; Lotan R; Roth J A; Mitchell M F
Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.
Cancer research 1996;56(13):3047-54.
1996: Kim S K; Fan Y; Papadimitrakopoulou V; Clayman G; Hittelman W N; Hong W K; Lotan R; Mao L
DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.
Cancer research 1996;56(11):2519-21.
1996: Oridate N; Lotan D; Xu X C; Hong W K; Lotan R
Differential induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in human head and neck squamous cell carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(5):855-63.
1996: Oridate N; Esumi N; Lotan D; Hing W K; Rochette-Egly C; Chambon P; Lotan R
Implication of retinoic acid receptor gamma in squamous differentiation and response to retinoic acid in head and neck SqCC/Y1 squamous carcinoma cells.
Oncogene 1996;12(9):2019-28.
1996: Lippman S M; Kalvakolanu D V; Lotan R
Retinoids and interferons in non-melanoma skin cancer.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):219-22.
1995: Xu X C; Lee J S; Lippman S M; Ro J Y; Hong W K; Lotan R
Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1995;4(8):871-6.
1995: Kim Y H; Dohi D F; Han G R; Zou C P; Oridate N; Walsh G L; Nesbitt J C; Xu X C; Hong W K; Lotan R
Retinoid refractoriness occurs during lung carcinogenesis despite functional retinoid receptors.
Cancer research 1995;55(23):5603-10.
1995: Xu X C; Zile M H; Lippman S M; Lee J S; Lee J J; Hong W K; Lotan R
Anti-retinoic acid (RA) antibody binding to human premalignant oral lesions, which occurs less frequently than binding to normal tissue, increases after 13-cis-RA treatment in vivo and is related to RA receptor beta expression.
Cancer research 1995;55(23):5507-11.
1995: Mitchell M F; Hittelman W K; Lotan R; Nishioka K; Tortolero-Luna G; Richards-Kortum R; Wharton J T; Hong W K
Chemoprevention trials and surrogate end point biomarkers in the cervix.
Cancer 1995;76(10 Suppl):1956-77.
1995: Xu X C; el-Naggar A K; Lotan R
Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications.
The American journal of pathology 1995;147(3):815-22.
1995: Ki Hong W; Lippman S M; Hittelman W N; Lotan R
Retinoid chemoprevention of aerodigestive cancer: from basic research to the clinic.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(7):677-86.
1995: Ohannesian D W; Lotan D; Thomas P; Jessup J M; Fukuda M; Gabius H J; Lotan R
Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells.
Cancer research 1995;55(10):2191-9.
1995: Lotan R; Xu X C; Lippman S M; Ro J Y; Lee J S; Lee J J; Hong W K
Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin.
The New England journal of medicine 1995;332(21):1405-10.
1995: Lotan R; Dawson M I; Zou C C; Jong L; Lotan D; Zou C P
Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.
Cancer research 1995;55(2):232-6.
1995: Lippman S M; Shin D M; Lee J J; Batsakis J G; Lotan R; Tainsky M A; Hittelman W N; Hong W K
p53 and retinoid chemoprevention of oral carcinogenesis.
Cancer research 1995;55(1):16-9.
1995: Mitchell M F; Hittelman W N; Lotan R; Nishioka K; Tortolero-Luna G; Richards-Kortum R; Hong W K
Chemoprevention trials in the cervix: design, feasibility, and recruitment.
Journal of cellular biochemistry. Supplement 1995;23():104-12.
1995: Oridate N; Lotan D; Mitchell M F; Hong W K; Lotan R
Inhibition of proliferation and induction of apoptosis in cervical carcinoma cells by retinoids: implications for chemoprevention.
Journal of cellular biochemistry. Supplement 1995;23():80-6.
1995: Lotan R M
Squamous differentiation and retinoids.
Cancer treatment and research 1995;74():43-72.
1994: Ohannesian D W; Lotan D; Lotan R
Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate.
Cancer research 1994;54(22):5992-6000.
1994: Mitchell M F; Hittelman W N; Hong W K; Lotan R; Schottenfeld D
The natural history of cervical intraepithelial neoplasia: an argument for intermediate endpoint biomarkers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1994;3(7):619-26.
1994: Lotan R; Belloni P N; Tressler R J; Lotan D; Xu X C; Nicolson G L
Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion.
Glycoconjugate journal 1994;11(5):462-8.
1994: Zou C P; Clifford J L; Xu X C; Sacks P G; Chambon P; Hong W K; Lotan R
Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines.
Cancer research 1994;54(20):5479-87.
1994: Xu X C; Ro J Y; Lee J S; Shin D M; Hong W K; Lotan R
Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues.
Cancer research 1994;54(13):3580-7.
1994: Xu X C; Clifford J L; Hong W K; Lotan R
Detection of nuclear retinoic acid receptor mRNA in histological tissue sections using nonradioactive in situ hybridization histochemistry.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1994;3(2):122-31.
1994: Lotan R
Suppression of squamous cell carcinoma growth and differentiation by retinoids.
Cancer research 1994;54(7 Suppl):1987s-1990s.
1994: Lotan R; Ito H; Yasui W; Yokozaki H; Lotan D; Tahara E
Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomas.
International journal of cancer. Journal international du cancer 1994;56(4):474-80.
1993: Dhingra K; Papadopoulos N; Lippman S; Lotan R; Legha S S
Phase II study of alpha-interferon and 13-cis-retinoic acid in metastatic melanoma.
Investigational new drugs 1993;11(1):39-43.
1993: Lotan R
Squamous cell differentiation markers in normal, premalignant, and malignant epithelium: effects of retinoids.
Journal of cellular biochemistry. Supplement 1993;17F():167-74.
1992: Lotan R; Amos B; Watanabe H; Raz A
Suppression of melanoma cell motility factor receptor expression by retinoic acid.
Cancer research 1992;52(18):4878-84.
1992: Lee J S; Lippman S M; Hong W K; Ro J Y; Kim S Y; Lotan R; Hittelman W N
Determination of biomarkers for intermediate end points in chemoprevention trials.
Cancer research 1992;52(9 Suppl):2707s-2710s.
1992: Lotan R; Pieniazek J; George M D; Jetten A M
Identification of a new squamous cell differentiation marker and its suppression by retinoids.
Journal of cellular physiology 1992;151(1):94-102.
1991: Lotan R; Matsushita Y; Ohannesian D; Carralero D; Ota D M; Cleary K R; Nicolson G L; Irimura T
Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression.
Carbohydrate research 1991;213():47-57.
1991: Lotan R
Retinoids as modulators of tumor cells invasion and metastasis.
Seminars in cancer biology 1991;2(3):197-208.
1991: Poddar S; Hong W K; Thacher S M; Lotan R
Retinoic acid suppression of squamous differentiation in human head-and-neck squamous carcinoma cells.
International journal of cancer. Journal international du cancer 1991;48(2):239-47.
1991: Irimura T; Matsushita Y; Sutton R C; Carralero D; Ohannesian D W; Cleary K R; Ota D M; Nicolson G L; Lotan R
Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages.
Cancer research 1991;51(1):387-93.
1991: Lotan R; Clifford J L
Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1991;45(4-5):145-56.
1990: Amos B; Lotan R
Modulation of lysosomal-associated membrane glycoproteins during retinoic acid-induced embryonal carcinoma cell differentiation.
The Journal of biological chemistry 1990;265(31):19192-8.
1990: Clifford J L; Petkovich M; Chambon P; Lotan R
Modulation by retinoids of mRNA levels for nuclear retinoic acid receptors in murine melanoma cells.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1546-55.
1990: Hong W K; Lippman S M; Itri L M; Karp D D; Lee J S; Byers R M; Schantz S P; Kramer A M; Lotan R; Peters L J
Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.
The New England journal of medicine 1990;323(12):795-801.
1990: Amos B; Lotan D; Lotan R
Increased fucosylation of high-molecular-weight glycoproteins accompanies retinoic-acid-induced differentiation of F-9 embryonal carcinoma cells.
International journal of cancer. Journal international du cancer 1990;46(1):86-94.
1990: Lotan R; Francis G E; Freeman C S; Waxman S
Differentiation therapy.
Cancer research 1990;50(11):3453-64.
1990: Lippman S M; Lee J S; Lotan R; Hittelman W; Wargovich M J; Hong W K
Biomarkers as intermediate end points in chemoprevention trials.
Journal of the National Cancer Institute 1990;82(7):555-60.
1990: Shin D M; Gimenez I B; Lee J S; Nishioka K; Wargovich M J; Thacher S; Lotan R; Slaga T J; Hong W K
Expression of epidermal growth factor receptor, polyamine levels, ornithine decarboxylase activity, micronuclei, and transglutaminase I in a 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis model.
Cancer research 1990;50(8):2505-10.
1990: Wood W R; Seftor E A; Lotan D; Nakajima M; Misiorowski R L; Seftor R E; Lotan R; Hendrix M J
Retinoic acid inhibits human melanoma tumor cell invasion.
Anticancer research 1990;10(2A):423-32.
1990: Steck P A; Hadi A; Lotan R; Yung W K
Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells.
Journal of cellular biochemistry 1990;42(2):83-94.
1990: Lippman S M; Lee J S; Lotan R; Hong W K
Chemoprevention of upper aerodigestive tract cancers: a report of the third Upper Aerodigestive Cancer Task Force workshop.
Head & neck 1990;12(1):5-20.
1990: Amos B; Deutsch V; Lotan R
Modulation by all-trans retinoic acid of glycoprotein glycosylation in murine melanoma cells: enhancement of fucosyl- and galactosyltransferase activities.
Cancer biochemistry biophysics 1990;11(1):31-43.
1990: Lippman S M; Toth B B; Batsakis J G; Weber R S; McCarthy K S; Hays G L; Wargovich M J; Lee J S; Thacher S; Lotan R
Modulation by 13-cis retinoic acid of biologic markers as indicators of intermediate endpoints in human oral carcinogenesis.
Progress in clinical and biological research 1990;339():179-91.
1989: Lotan R; Lotan D; Carralero D M
Modulation of galactoside-binding lectins in tumor cells by differentiation-inducing agents.
Cancer letters 1989;48(2):115-22.
1989: Sacks P G; Oke V; Amos B; Vasey T; Lotan R
Modulation of growth, differentiation and glycoprotein synthesis by beta-all-trans retinoic acid in a multicellular tumor spheroid model for squamous carcinoma of the head and neck.
International journal of cancer. Journal international du cancer 1989;44(5):926-33.
1989: Sacks P G; Oke V; Vasey T; Lotan R
Retinoic acid inhibition of a head and neck multicellular tumor spheroid model.
Head & neck 1989;11(3):219-25.
1989: Nakajima M; Lotan D; Baig M M; Carralero R M; Wood W R; Hendrix M J; Lotan R
Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells.
Cancer research 1989;49(7):1698-706.
1989: Lotan R; Carralero D; Lotan D; Raz A
Biochemical and immunological characterization of K-1735P melanoma galactoside-binding lectins and their modulation by differentiation inducers.
Cancer research 1989;49(5):1261-8.
1989: Yung W K; Lotan R; Lee P; Lotan D; Steck P A
Modulation of growth and epidermal growth factor receptor activity by retinoic acid in human glioma cells.
Cancer research 1989;49(4):1014-9.
1988: Lotan R; Lotan D; Amos B
Enhancement of sialyltransferase in two melanoma cell lines that are growth-inhibited by retinoic acid results in increased sialylation of different cell-surface glycoproteins.
Experimental cell research 1988;177(2):284-94.
1988: Lotan R; Raz A
Endogenous lectins as mediators of tumor cell adhesion.
Journal of cellular biochemistry 1988;37(1):107-17.
1988: Lotan R
Vitamin A analogs (retinoids) as biological response modifiers.
Progress in clinical and biological research 1988;259():261-71.
1988: Lotan R; Raz A
Lectins in cancer cells.
Annals of the New York Academy of Sciences 1988;551():385-96; discussion 396-8.
1987: Lotan R; Irimura T
Enhanced glycosylation of a melanoma cell surface glycoprotein by retinoic acid: carbohydrate chain analysis by lectin binding.
Cancer biochemistry biophysics 1987;9(3):211-21.

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