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Yi-Jia Lou

Research Profile

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Anatomy

Physiology

Cell Differentiation

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Publications

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Rong-rong Tao; Yun Tian; Wei-feng Ye; Xue-jing Shao; Kohji Fukunaga; Feng Han; Ji-Yun Huang; Mei-hua Liao; Yi-Jia Lou; Ying-mei Lu
Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin.
Yi-Jia Lou
CEBPA-CEBPG axis as a novel promising therapeutic target in acute myeloid leukemia.
Gen-Sheng Zhang; Kohji Fukunaga; Ji-Yun Huang; Mei-Hua Liao; Yi-Jia Lou; Ying-Mei Lu; Rong-Rong Tao; Yun Tian; Rui Wang; Wei-Feng Ye; Feng Han
The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia.

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All Publications

2013: Rong-rong Tao; Yun Tian; Wei-feng Ye; Xue-jing Shao; Kohji Fukunaga; Feng Han; Ji-Yun Huang; Mei-hua Liao; Yi-Jia Lou; Ying-mei Lu
Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin.
Journal of pineal research 2013;54(3):271-81.
2013: Yi-Jia Lou
CEBPA-CEBPG axis as a novel promising therapeutic target in acute myeloid leukemia.
Acta pharmacologica Sinica 2013;34(2):185-6.
2013: Gen-Sheng Zhang; Kohji Fukunaga; Ji-Yun Huang; Mei-Hua Liao; Yi-Jia Lou; Ying-Mei Lu; Rong-Rong Tao; Yun Tian; Rui Wang; Wei-Feng Ye; Feng Han
The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia.
CNS neuroscience & therapeutics 2013;19(1):53-60.
2012: Dan-Yan Zhu; Jia-Qi Huang; Xing Pan; Ying-Ying Zhang; Li-Min Zhou; Yi-Jia Lou
Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells.
Stem cells and development 2012;21(12):2130-41.
2012: Wei-feng Ye; Gen-sheng Zhang; Ji-yun Huang; Mei-hua Liao; Yi-Jia Lou; Rong-rong Tao; Yun Tian; Feng Han
[Effect of chronic lead exposure on expression of autophagy-associated proteins in rat hippocampus].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2012;41(4):402-9.
2012: Jia-ying Wu; Da-Yuan Zhu; Wei-jie Zhu; Mei-yuan Chen; Yan Liu; Yuan-yuan Shen; Zhi-qiang Wang; Yi-Jia Lou
[Ginsenoside Rg1 antagonizes β-amyloid peptide-induced apoptosis in primarily cultured rat neurons via mitochondrial pathway].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2012;41(4):393-401.
2012: Yu-qin Mei; Yong-ping Yu; Xing-guang Liang; Yi-Jia Lou; Da-Yuan Zhu
[Establishment of optimized neuronal differentiation-promoting model derived from P19 embryonic carcinoma cells].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2012;41(4):381-5.
2012: Yi-ning Gao; Yu-qin Mei; Zong-fu Pan; Dan-ying Wang; Zhi-qiang Wang; Da-Yuan Zhu; Yi-Jia Lou
[Phenotype-based primary screening for drugs promoting neuronal subtype differentiation in embryonic stem cells with light microscope].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2012;41(4):373-80.
2012: Xing-guang Liang; Bo-wen Wu; Wei-chen Zhang; Li-min Zhou; Da-Yuan Zhu; Yi-Jia Lou
[Expression of Junctophilin 1 during cardiogenesis of mouse embryonic stem cells and rat embryos].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2012;41(4):359-65.
2012: Yi-Jia Lou; Lu Li; Bo-wen Wu
[Embryonic stem cells and regeneration-promoting drug research & development].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2012;41(4):353-8.
2011: Dan-Yan Zhu; Rong Cui; Huan Li; Ying-Ying Zhang; Li-Min Zhou; Yi-Jia Lou
Involvement of ubiquitin-proteasome system in icariin-induced cardiomyocyte differentiation of embryonic stem cells using two-dimensional gel electrophoresis.
Journal of cellular biochemistry 2011;112(11):3343-53.
2011: H Y Yang; X H Zheng; Y Du; Z Chen; D Y Zhu; Yi-Jia Lou
Kinetics of aristolochic acid I after oral administration of Radix Aristolochiae or Guanxinsuhe preparation in canines.
Journal of ethnopharmacology 2011;135(2):569-74.
2011: Dan-yin Wang; Yu-zhe Hu; Si-si Kong; Yong-ping Yu; Dan-yan Zhu; Yi-Jia Lou
Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation.
Acta pharmacologica Sinica 2011;32(4):425-32.
2011: Feng Han; Rong-rong Tao; Gen-sheng Zhang; Ying-mei Lu; Lu-lu Liu; Ying-xian Chen; Yi-Jia Lou; Kohji Fukunaga; Ze-Hui Hong
Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.
Journal of pineal research 2011;50(3):281-91.
2011: Yi-Jia Lou; Xing-guang Liang
Embryonic stem cell application in drug discovery.
Acta pharmacologica Sinica 2011;32(2):152-9.
2010: Qi-Bing Liu; Lu-Lu Liu; Ying-Mei Lu; Rong-Rong Tao; Ji-Yun Huang; Norifumi Shioda; Shigeki Moriguchi; Kohji Fukunaga; Feng Han; Yi-Jia Lou
The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells.
Toxicology and applied pharmacology 2010;244(3):374-84.
2010: Da-Yuan Zhu; Jia-Ying Wu; Huan Li; Jie-Ping Yan; Mei-Yuan Guo; Yan-Bo Wo; Yi-Jia Lou
PPAR-beta facilitating maturation of hepatic-like tissue derived from mouse embryonic stem cells accompanied by mitochondriogenesis and membrane potential retention.
Journal of cellular biochemistry 2010;109(3):498-508.
2010: Zi-qi Ye; Wen-bo Ding; Zhe Chen; Yan-dong Zhang; Yue-Ping Yu; Yi-Jia Lou
[4, 8-disubstituted-8, 9-dihydro-pyrazine[2,3-g]quinazoline-7(6H)-ketones: a novel class of antitumor agents].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2010;39(1):49-56.
2009: Hao-shu Wu; Di-Feng Zhu; Chang-xin Zhou; Chu-Rui Feng; Yi-Jia Lou; Bo Yang; Qiao-jun He
Insulin sensitizing activity of ethyl acetate fraction of Acorus calamus L. in vitro and in vivo.
Journal of ethnopharmacology 2009;123(2):288-92.
2009: Xian-Ning Zhang; Lou-Yang Qi; Da-Yuan Zhu; Yi-Jia Lou
[Effect of concanavalin A on expression of MAPEG mRNA in Balb/c mouse brain].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2009;38(3):255-9.
2009: Min-Hua Xu; Jia-Ying Wu; Li-Li Ou; Da-Yuan Zhu; Yue-Ping Yu; Yi-Jia Lou
[Transcription of cytoskeleton protein genes in differentiation of neurons from mouse embryonic stem cells induced by small molecules].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2009;38(3):242-8.
2008: Dan-Yan Zhu; Yue Du; Xin Huang; Mei-Yuan Guo; Kui-Fen Ma; Yong-Ping Yu; Yi-Jia Lou
MAPEG expression in mouse embryonic stem cell-derived hepatic tissue system.
Stem cells and development 2008;17(4):775-83.
2008: Ling Ding; Xing-Guang Liang; Ying Hu; Dan-Yan Zhu; Yi-Jia Lou
Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.
Stem cells and development 2008;17(4):751-60.
2008: Kui-Fen Ma; Hong-Yu Yang; Zhe Chen; Luo-Yang Qi; Da-Yuan Zhu; Yi-Jia Lou
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.
World journal of gastroenterology : WJG 2008;14(17):2748-56.
2008: Yan-bo Wo; Da-Yuan Zhu; Ying Hu; Zhi-Qiang Wang; Jian Liu; Yi-Jia Lou
Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells.
Journal of cellular biochemistry 2008;103(5):1536-50.
2007: Yao-Dong Wu; Yi-Jia Lou
A steroid fraction of chloroform extract from bee pollen of Brassica campestris induces apoptosis in human prostate cancer PC-3 cells.
Phytotherapy research : PTR 2007;21(11):1087-91.
2007: Ling Ding; Xing-Guang Liang; Da-Yuan Zhu; Yi-Jia Lou
Icariin promotes expression of PGC-1alpha, PPARalpha, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro.
Acta pharmacologica Sinica 2007;28(10):1541-9.
2007: Qing-wei Zhao; Xin Huang; Yi-Jia Lou; Nadine Weber; Peter Proksch
Effects of ethanol extracts from Adzuki bean (Phaseolus angularis Wight.) and Lima bean (Phaseolus lunatus L.) on estrogen and progesterone receptor phenotypes of MCF-7/BOS cells.
Phytotherapy research : PTR 2007;21(7):648-52.
2007: Shu-Long Yang; Xin Huang; Hai-Fei Chen; Dan Xu; Li-Jun Chen; Yin Kong; Yi-Jia Lou
Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats.
The Journal of surgical research 2007;140(1):36-44.
2007: Hao-shu Wu; Ying-yin Li; Lin-jia Weng; Chang-xin Zhou; Qiao-jun He; Yi-Jia Lou
A fraction of Acorus calamus L. extract devoid of beta-asarone enhances adipocyte differentiation in 3T3-L1 cells.
Phytotherapy research : PTR 2007;21(6):562-4.
2007: Yi-Jia Lou; Zhe Chen
[Cytomics: a new chance and promise for pharmacology and toxicology research].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2007;36(3):209-16.
2007: Yao-Dong Wu; Yi-Jia Lou
Brassinolide, a plant sterol from pollen of Brassica napus L., induces apoptosis in human prostate cancer PC-3 cells.
Die Pharmazie 2007;62(5):392-5.
2007: Ling Ding; Xing-Guang Liang; Yi-Jia Lou
Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor alpha inhibitor GW6471 in murine embryonic stem cells in vitro.
Acta pharmacologica Sinica 2007;28(5):634-42.
2007: Hao-shu Wu; Juan-Hong Yu; Ying-Yin Li; Yu-She Yang; Qiao-jun He; Yi-Jia Lou; Ru-yun Ji
Insulin-sensitizing effects of a novel alpha-methyl- alpha -phenoxylpropionate derivative in vitro.
Acta pharmacologica Sinica 2007;28(3):417-22.
2007: Shu-Long Yang; Yi-Jia Lou
Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats.
Biochemical pharmacology 2007;73(5):724-35.
2007: Shu-Long Yang; Li-jun Chen; Yin Kong; Dan Xu; Yi-Jia Lou
Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway.
Pharmacology 2007;80(1):11-20.
2006: Qiang Shi; Hai-Fei Chen; Yi-Jia Lou
Further evidence that rat liver microsomal glutathione transferase 1 is not a cellular protein target for S-nitrosylation.
Chemico-biological interactions 2006;162(3):228-36.
2006: Ping Huang; Su-Wen Yang; Wei-Hua Huang; Fan-Zhi Kong; Yi-Jia Lou
[Effect of Rongshi granule on renal stone formation and osteopontin expression in rat urolithiasis model].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2006;31(14):1188-91.
2006: Lin-hai Qu; Ming Zheng; Yi-Jia Lou
[Studies on extraction process optimization of Panax notogingseng saponins].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2006;29(6):593-5.
2006: Qing-wei Zhao; Yi-Jia Lou
[Estrogenic activity and its mechanism of ethanol extract from black soybean].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2006;31(10):825-8.
2006: Zhi-qiang Wang; Nadine Weber; Yi-Jia Lou; Peter Proksch
Prenylflavonoids as nonsteroidal phytoestrogens and related structure-activity relationships.
ChemMedChem 2006;1(4):482-8.
2006: Da-Yuan Zhu; Yi-Jia Lou
Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro.
Acta pharmacologica Sinica 2006;27(3):311-20.
2006: Bo Yang; Qiao-jun He; Da-Yuan Zhu; Yi-Jia Lou; Rui-ying Fang
Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo.
Cancer chemotherapy and pharmacology 2006;57(2):268-73.
2005: Qiao-jun He; Bo Yang; Yi-Jia Lou; Rui-ying Fang
Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo.
Asian journal of andrology 2005;7(4):389-93.
2005: Hua-ying Ye; Yi-Jia Lou
Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2005;12(10):735-41.
2005: Hai-yong Chen; Chang-xin Zhou; Yi-Jia Lou; Zhi-hong Duan; Yu Zhao
[Chemical constituents from Elsholtzia blanda].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2005;30(20):1589-91.
2005: Da-Yuan Zhu; Yi-Jia Lou
Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro.
Acta pharmacologica Sinica 2005;26(4):477-85.
2005: Qiang Shi; Yi-Jia Lou
Microsomal glutathione transferase 1 is not S-nitrosylated in rat liver microsomes or in endotoxin challenged rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;51(4):303-10.
2005: Hua-ying Ye; Jian Liu; Yi-Jia Lou
[Preparation of two derivatives from icariin and investigation of their estrogen-like effects].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 2005;34(2):131-6.
2004: Zhi-qiang Wang; Yi-Jia Lou
Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells.
European journal of pharmacology 2004;504(3):147-53.
2004: Jian Liu; Yi-Jia Lou
Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin.
Journal of pharmaceutical and biomedical analysis 2004;36(2):365-70.
2003: Jie Zhang; Yi-Jia Lou
Relationship between activation of microsomal glutathione S-transferase and metabolism behavior of chlorambucil.
Pharmacological research : the official journal of the Italian Pharmacological Society 2003;48(6):623-30.
2003: Qin-Zhu Zheng; Yi-Jia Lou
Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and protective effect of glycyrrhizin in vitro.
Acta pharmacologica Sinica 2003;24(8):771-7.
2000: Y Hong; Yi-Jia Lou
Effects of cyclophosphamide on protein expression of rat embryo at end of pre-gastrulation stage in vivo.
Acta pharmacologica Sinica 2000;21(6):554-6.
1997: Yi-Jia Lou; Y Hong
Immunosurgical studies on cytological and cytogenetic toxicity analysis of rat blastocysts after in vivo exposure to cyclophosphamide.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1997;18(3):259-62.