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Mark Louder

Research Profile

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HIV-1

Chemicals & Drugs

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Publications

TOP 3
Ivelin S Georgiev; Young Do Kwon; Han R Altae-Tran; Robert T Bailer; Gwo-Yu Chuang; Mark Connors; Nicole A Doria-Rose; Mark K Louder; Malcolm A Martin; John R Mascola; Krisha McKee; Stephen A Migueles; Stephanie Moquin; Lynn Morris; Martha Nason; Yoshiaki Nishimura; Sijy O'Dell; Gilad Ofek; Marie Pancera; Stephen D Schmidt; Lawrence Shapiro; Sanjay Srivatsan; Ryan P Staupe; Tongqing Zhou; Peter D Kwong
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Jiang Zhu; S Munir Alam; Julie Blinn; Dennis R Burton; Joshua Eudailey; Barton F Haynes; Wayne C Koff; Krissey E Lloyd; Mark K Louder; Gabriel Lu; John R Mascola; Krisha McKee; James C Mullikin; Gilad Ofek; Marie Pancera; Robert Parks; Lawrence Shapiro; Melissa Simek; Jeff Skinner; Yongping Yang; Baoshan Zhang; Zhenhai Zhang; Peter D Kwong
Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
Marie Pancera; Jonathan Stuckey; Yongping Yang; Jiang Zhu; Dennis R Burton; Jason Gorman; Wayne C Koff; Mark K Louder; Gabriel Lu; John R Mascola; Jason S McLellan; Peter D Kwong
N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.

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All Publications

2013: Ivelin S Georgiev; Young Do Kwon; Han R Altae-Tran; Robert T Bailer; Gwo-Yu Chuang; Mark Connors; Nicole A Doria-Rose; Mark K Louder; Malcolm A Martin; John R Mascola; Krisha McKee; Stephen A Migueles; Stephanie Moquin; Lynn Morris; Martha Nason; Yoshiaki Nishimura; Sijy O'Dell; Gilad Ofek; Marie Pancera; Stephen D Schmidt; Lawrence Shapiro; Sanjay Srivatsan; Ryan P Staupe; Tongqing Zhou; Peter D Kwong
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Science (New York, N.Y.) 2013;340(6133):751-6.
2013: Jiang Zhu; S Munir Alam; Julie Blinn; Dennis R Burton; Joshua Eudailey; Barton F Haynes; Wayne C Koff; Krissey E Lloyd; Mark K Louder; Gabriel Lu; John R Mascola; Krisha McKee; James C Mullikin; Gilad Ofek; Marie Pancera; Robert Parks; Lawrence Shapiro; Melissa Simek; Jeff Skinner; Yongping Yang; Baoshan Zhang; Zhenhai Zhang; Peter D Kwong
Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6470-5.
2013: Marie Pancera; Jonathan Stuckey; Yongping Yang; Jiang Zhu; Dennis R Burton; Jason Gorman; Wayne C Koff; Mark K Louder; Gabriel Lu; John R Mascola; Jason S McLellan; Peter D Kwong
N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.
PloS one 2013;8(2):e55701.
2012: Jinghe Huang; Hiromi Imamichi; Peter D Kwong; Leo Laub; Nancy S Longo; Mark K Louder; John R Mascola; Stephen A Migueles; Gilad Ofek; Shailendra K Sharma; Tao Wang; Richard Wyatt; Yongping Yang; Baoshan Zhang; S Munir Alam; Robert T Bailer; Bimal Chakrabarti; Nicole A Doria-Rose; Barton F Haynes; Mark Connors
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Nature 2012;491(7424):406-12.
2012: Yuxing Li; Nancy S Longo; Mark K Louder; John R Mascola; Sijy O'Dell; Christian Poulsen; Mario Roederer; Stephen D Schmidt; Richard Wilson; Xueling Wu; Bimal K Chakrabarti; Mark Connors; Nicole Doria-Rose; Javier Guenaga; Carl-Magnus Hogerkorp; Richard Wyatt
HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins.
Journal of virology 2012;86(20):11231-41.
2012: Rebecca M Lynch; Salim Abdool Karim; Myron Cohen; Rebecca DerSimonian; Zelda Euler; Elin S Gray; Barton F Haynes; Jennifer Kirchherr; Mark K Louder; David C Montefiori; Lynn Morris; Gary Nabel; Stephen D Schmidt; Hanneke Schuitemaker; Sengeziwe Sibeko; Kelly Soderberg; Georgia D Tomaras; Lillian Tran; Zhi-Yong Yang; John R Mascola
The development of CD4 binding site antibodies during HIV-1 infection.
Journal of virology 2012;86(14):7588-95.
2012: Nicole A Doria-Rose; Mark K Louder; Robert T Bailer; Krisha McKee; Martha Nason; Sijy O'Dell; Stephen D Schmidt; Michael S Seaman; Zhongjia Yang; John R Mascola
HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes.
Journal of virology 2012;86(6):3393-7.
2011: Zhongyu Zhu; Weizao Chen; Genevieve G Fouda; Barton F Haynes; Kristina-Ana Klaric; Peter D Kwong; Hua-Xin Liao; Mark K Louder; John R Mascola; David Montefiori; M Anthony Moody; Gilad Ofek; John Owens; Prabakaran Ponraj; Haiyan Rebekah Qin; Robert Schutte; Jamie K Scott; Xiaoying Shen; Emily Streaker; Georgia D Tomaras; Yanping Wang; Yongping Yang; Qi Zhao; Dimiter S Dimitrov
Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies.
Journal of virology 2011;85(21):11401-8.
2011: Priyamvada Acharya; Carole A Bewley; Asim K Debnath; Cajetan Dogo-Isonagie; Leah L Frye; Jeremy R Greenwood; James A Hoxie; Judith M LaLonde; Son N Lam; George J Leslie; Mark K Louder; Timothy S Luongo; Loic MARTIN; John R Mascola; K Shawn Watts; Peter D Kwong
Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry.
ACS chemical biology 2011;6(10):1069-77.
2011: Yuxing Li; Mark K Louder; Dennis R Burton; Yu Feng; Barney S Graham; Javier Guenaga; Barton F Haynes; Julie E Ledgerwood; Krisha McKee; Sijy O'Dell; Stephen D Schmidt; Laura M Walker; Xueling Wu; Richard Wyatt; John R Mascola
Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.
Journal of virology 2011;85(17):8954-67.
2010: Xueling Wu; Zhi-Yong Yang; Yuxing Li; Carl-Magnus Hogerkorp; William R Schief; Michael S Seaman; Tongqing Zhou; Stephen D Schmidt; Lan Wu; Ling Xu; Nancy S Longo; Krisha McKee; Sijy O'Dell; Mark K Louder; Diane L Wycuff; Yu Feng; Martha Nason; Nicole Doria-Rose; Mark Connors; Peter D Kwong; Mario Roederer; Richard Wyatt; Gary Nabel; John R Mascola
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.
Science (New York, N.Y.) 2010;329(5993):856-61.
2009: Lan Wu; Tongqing Zhou; Zhi-Yong Yang; Krisha Svehla; Sijy O'Dell; Mark K Louder; Ling Xu; John R Mascola; Dennis R Burton; James A Hoxie; Robert W Doms; Peter D Kwong; Gary Nabel
Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.
Journal of virology 2009;83(10):5077-86.
2009: Yuxing Li; Krisha Svehla; Mark K Louder; Diane Wycuff; Sanjay Phogat; Min Tang; Stephen A Migueles; Xueling Wu; Adhuna Phogat; George M Shaw; Mark Connors; James A Hoxie; John R Mascola; Richard Wyatt
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals.
Journal of virology 2009;83(2):1045-59.
2008: Julie E Martin; Mark K Louder; LaSonji A Holman; Ingelise J Gordon; Mary E Enama; Brenda D Larkin; Charla A Andrews; Leatrice Vogel; Richard A Koup; Mario Roederer; Robert T Bailer; Phillip L Gomez; Martha Nason; John R Mascola; Gary Nabel; Barney S Graham
A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial.
Vaccine 2008;26(50):6338-43.
2007: Yuxing Li; Stephen A Migueles; Brent Welcher; Krisha Svehla; Adhuna Phogat; Mark K Louder; Xueling Wu; George M Shaw; Mark Connors; Richard Wyatt; John R Mascola
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Nature medicine 2007;13(9):1032-4.
2007: Jae-Ouk Kim; Bimal K Chakrabarti; Anuradha Guha-Niyogi; Mark K Louder; John R Mascola; Lakshmanan Ganesh; Gary Nabel
Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2.
Journal of virology 2007;81(3):1444-50.
2005: Mark K Louder; Anna Sambor; Elena Chertova; Tai Hunte; Sarah Barrett; Fallon Ojong; eric sanders-buell; Susan Zolla-Pazner; Francine E McCutchan; James D Roser; Dana Gabuzda; Jeffrey D Lifson; John R Mascola
HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.
Virology 2005;339(2):226-38.
2005: Anna Smed-Sörensen; Karin Loré; Jayanand Vasudevan; Mark K Louder; Jan Andersson; John R Mascola; Anna-Lena Spetz; Richard A Koup
Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells.
Journal of virology 2005;79(14):8861-9.
2005: Bimal K Chakrabarti; Xu Ling; Zhi-Yong Yang; David C Montefiori; Amos Panet; Wing-Pui Kong; Brent Welcher; Mark K Louder; John R Mascola; Gary Nabel
Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate.
Vaccine 2005;23(26):3434-45.
2005: Christoph Grundner; Yuxing Li; Mark K Louder; John R Mascola; Xinzhen Yang; Joseph Sodroski; Richard Wyatt
Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.
Virology 2005;331(1):33-46.
2005: John R Mascola; Anna Sambor; Kristin Beaudry; Sampa Santra; Brent Welcher; Mark K Louder; Thomas C VanCott; Yue Huang; Bimal K Chakrabarti; Wing-Pui Kong; Zhi-Yong Yang; Ling Xu; David C Montefiori; Gary Nabel; Norman L Letvin
Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins.
Journal of virology 2005;79(2):771-9.
2004: Miroslaw K Gorny; Kathy Revesz; Constance Williams; Barbara Volsky; Mark K Louder; Christopher A Anyangwe; Chavdar Krachmarov; Samuel C Kayman; Abraham Pinter; Arthur Nadas; Phillipe N Nyambi; John R Mascola; Susan Zolla-Pazner
The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.
Journal of virology 2004;78(5):2394-404.
2003: Lakshmanan Ganesh; Ezra Burstein; Anuradha Guha-Niyogi; Mark K Louder; John R Mascola; Leo W J Klomp; Cisca Wijmenga; Colin S Duckett; Gary Nabel
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.
Nature 2003;426(6968):853-7.
2002: Mary A Marovich; John R Mascola; Michael A Eller; Mark K Louder; Pierre A Caudrelier; Raphaelle El Habib; Silvia Ratto-Kim; Josephine H Cox; Jeffrey R Currier; Bruce L Levine; Carl H June; Wendy B Bernstein; Merlin L Robb; Beatrice Schuler-Thurner; Ralph M Steinman; Deborah L Birx; Sarah Schlesinger-Frankel
Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells.
The Journal of infectious diseases 2002;186(9):1242-52.
2002: John R Mascola; Mark K Louder; Christine Winter; Ranjani Prabhakara; Stephen C De Rosa; Daniel C Douek; Brenna J Hill; Dana Gabuzda; Mario Roederer
Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells.
Journal of virology 2002;76(10):4810-21.
2001: Mary A Marovich; G Grouard-Vogel; Mark K Louder; Michael A Eller; Wellington Sun; Shuenn-Jue Wu; R Putvatana; G Murphy; B Tassaneetrithep; Timothy Burgess; Deborah L Birx; C Hayes; S Schlesinger-Frankel; John R Mascola
Human dendritic cells as targets of dengue virus infection.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2001;6(3):219-24.
2000: Mika Salminen; Philip K Ehrenberg; John R Mascola; Debora Elizabeth Sites (Dayhoff); R Merling; B Blake; Mark K Louder; S Hegerich; Victoria R Polonis; Deborah L Birx; Merlin L Robb; Francine E McCutchan; Nelson L Michael
Construction and biological characterization of infectious molecular clones of HIV-1 subtypes B and E (CRF01_AE) generated by the polymerase chain reaction.
Virology 2000;278(1):103-10.
2000: Shuenn-Jue Wu; G Grouard-Vogel; Wellington Sun; John R Mascola; Elena F Brachtel; R Putvatana; Mark K Louder; Luis Filgueira; Mary A Marovich; Henry K Wong; Andrew Blauvelt; Gerald S Murphy; Merlin L Robb; B L Innes; Deborah L Birx; Curtis G Hayes; Sarah Schlesinger Frankel
Human skin Langerhans cells are targets of dengue virus infection.
Nature medicine 2000;6(7):816-20.
1999: Stephanie K Brodine; Richard A Shaffer; Monica J Starkey; Sybil A Tasker; J L Gilcrest; Mark K Louder; Anthony J Barile; Thomas C VanCott; Maryanne Vahey; Francine E McCutchan; Deborah L Birx; D D Richman; John R Mascola
Drug resistance patterns, genetic subtypes, clinical features, and risk factors in military personnel with HIV-1 seroconversion.
Annals of internal medicine 1999;131(7):502-6.
1999: John R Mascola; Mark G Lewis; Gabriela Stiegler; D Harris; Thomas C VanCott; D Hayes; Mark K Louder; C R Brown; Christine V Sapan; Sarah Schlesinger Frankel; Y Lu; Merlin L Robb; H Katinger; Deborah L Birx
Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.
Journal of virology 1999;73(5):4009-18.
1998: Sarah Schlesinger Frankel; Ralph M Steinman; Nelson L Michael; S R Kim; N Bhardwaj; Melissa Pope; Mark K Louder; Philip K Ehrenberg; P W Parren; D R Burton; H Katinger; Thomas C VanCott; Merlin L Robb; Deborah L Birx; John R Mascola
Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells.
Journal of virology 1998;72(12):9788-94.
1998: Nicholas M Stamatos; John R Mascola; VS Kalyanaraman; Mark K Louder; L M Frampton; Deborah L Birx; Thomas C VanCott
Neutralizing antibodies from the sera of human immunodeficiency virus type 1-infected individuals bind to monomeric gp120 and oligomeric gp140.
Journal of virology 1998;72(12):9656-67.
1998: Nelson L Michael; Julie A E Nelson; Vineet N KewalRamani; G Chang; S J O'Brien; John R Mascola; Barbara Volsky; Mark K Louder; Gilbert C White; Dan R Littman; Ronald Swanstrom; Thomas R O'Brien
Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32.
Journal of virology 1998;72(7):6040-7.
1997: John R Mascola; Mark K Louder; Thomas C VanCott; Christine V Sapan; John S Lambert; L R Muenz; B Bunow; Deborah L Birx; Merlin L Robb
Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12.
Journal of virology 1997;71(10):7198-206.
1997: Nelson L Michael; Arthur E Brown; R F Voigt; Sarah Schlesinger Frankel; John R Mascola; K S Brothers; Mark K Louder; Deborah L Birx; Sharon Cassol
Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.
The Journal of infectious diseases 1997;175(6):1352-9.
1996: John R Mascola; Mark K Louder; S R Surman; Thomas C VanCott; XIAOFANG YU; J Bradac; Kevin R Porter; Kenrad E Nelson; M Girard; John G McNeil; Francine E McCutchan; Deborah L Birx; Donald S. Burke
Human immunodeficiency virus type 1 neutralizing antibody serotyping using serum pools and an infectivity reduction assay.
AIDS research and human retroviruses 1996;12(14):1319-28.