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John Louis

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TOP 3
Nils-Alexander Lakomek; John M Louis; Stephen J Stahl; Paul T Wingfield; Alexander Grishaev; Joshua D Kaufman; Ad Bax
Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales.
Justin L Lorieau; John M Louis; Alexander S Maltsev; Ad Bax
Modulating alignment of membrane proteins in liquid-crystalline and oriented gel media by changing the size and charge of phospholipid bicelles.
Justin L Lorieau; John M Louis; Ad Bax
The impact of influenza hemagglutinin fusion peptide length and viral subtype on its structure and dynamics.

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2013: Nils-Alexander Lakomek; John M Louis; Stephen J Stahl; Paul T Wingfield; Alexander Grishaev; Joshua D Kaufman; Ad Bax
Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales.
Angewandte Chemie (International ed. in English) 2013;52(14):3911-5.
2013: Justin L Lorieau; John M Louis; Alexander S Maltsev; Ad Bax
Modulating alignment of membrane proteins in liquid-crystalline and oriented gel media by changing the size and charge of phospholipid bicelles.
Journal of biomolecular NMR 2013;55(4):369-77.
2013: Justin L Lorieau; John M Louis; Ad Bax
The impact of influenza hemagglutinin fusion peptide length and viral subtype on its structure and dynamics.
Biopolymers 2013;99(3):189-95.
2012: Justin Lorieau; John M Louis; Charles D Schwieters; Adriaan Bax
pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(49):19994-9.
2012: Johnson Agniswamy; Annie Aniana; John M Louis; Jane M Sayer; Chen-Hsiang Shen; Irene T Weber
HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Biochemistry 2012;51(13):2819-28.
2012: Yunfeng Tie; Jozsef Tozser; Yuan-Fang Wang; Peter I Boross; Ting-Yi Chiu; Arun K Ghosh; Robert W Harrison; John M Louis; Irene T Weber
Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
Protein science : a publication of the Protein Society 2012;21(3):339-50.
2012: Hoi Sung Chung; John M Louis; Kevin McHale; William A Eaton
Single-molecule fluorescence experiments determine protein folding transition path times.
Science (New York, N.Y.) 2012;335(6071):981-4.
2012: Johnson Agniswamy; Jane M Sayer; Irene T Weber; John M Louis
Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.
Biochemistry 2012;51(5):1041-50.
2011: Justin Lorieau; John M Louis; Ad Bax
Whole-body rocking motion of a fusion peptide in lipid bilayers from size-dispersed 15N NMR relaxation.
Journal of the American Chemical Society 2011;133(36):14184-7.
2011: John M Louis; Annie Aniana; Irene T Weber; Jane M Sayer
Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(22):9072-7.
2011: John M Louis; Ying Zhang; Jane M Sayer; Yuan-Fang Wang; Robert W Harrison; Irene T Weber
The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.
Biochemistry 2011;50(21):4786-95.
2011: Elena Matei; John M Louis; JunGoo Jee; Angela M Gronenborn
NMR solution structure of a cyanovirin homolog from wheat head blight fungus.
Proteins 2011;79(5):1538-49.
2011: Hoi Sung Chung; Irina V Gopich; Kevin McHale; Troy Cellmer; John M Louis; William Eaton
Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein.
The journal of physical chemistry. A 2011;115(16):3642-56.
2011: Justin Lorieau; John M Louis; Adriaan Bax
Helical hairpin structure of influenza hemagglutinin fusion peptide stabilized by charge-dipole interactions between the N-terminal amino group and the second helix.
Journal of the American Chemical Society 2011;133(9):2824-7.
2010: Jane M Sayer; Johnson Agniswamy; Irene T Weber; John M Louis
Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.
Protein science : a publication of the Protein Society 2010;19(11):2055-72.
2010: Justin Lorieau; John M Louis; Adriaan Bax
The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11341-6.
2010: Rieko Ishima; Qingguo Gong; Yunfeng Tie; Irene T Weber; John M Louis
Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease.
Proteins 2010;78(4):1015-25.
2010: Hoi Sung Chung; John M Louis; William A Eaton
Distinguishing between protein dynamics and dye photophysics in single-molecule FRET experiments.
Biophysical journal 2010;98(4):696-706.
2010: Elena Gustchina; Mi Li; John M Louis; D Eric Anderson; John Lloyd; Christian Frisch; Carole A Bewley; Alla Gustchina; Alexander Wlodawer; G Marius Clore
Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.
PLoS pathogens 2010;6(11):e1001182.
2009: John M Louis; Rieko Ishima; Annie Aniana; Jane M Sayer
Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease.
Protein science : a publication of the Protein Society 2009;18(12):2442-53.
2009: Elena Gustchina; John M Louis; Christian Frisch; Francisco Ylera; Annette Lechner; Carole A Bewley; G Marius Clore
Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth.
Virology 2009;393(1):112-9.
2009: Liangqun Huang; Jane M Sayer; Marie Swinford; John M Louis; Chaoping Chen
Modulation of human immunodeficiency virus type 1 protease autoprocessing by charge properties of surface residue 69.
Journal of virology 2009;83(15):7789-93.
2009: Hoi Sung Chung; John M Louis; William Eaton
Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):11837-44.
2009: Jane M Sayer; John M Louis
Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
Proteins 2009;75(3):556-68.
2008: Andrey Yu Kovalevsky; John M Louis; Annie Aniana; Arun K Ghosh; Irene T Weber
Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease.
Journal of molecular biology 2008;384(1):178-92.
2008: Chun Tang; John M Louis; Annie Aniana; Jeong-Yong Suh; G Marius Clore
Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease.
Nature 2008;455(7213):693-6.
2008: Gabriella Miklóssy; József Tözsér; János Kádas; Rieko Ishima; John M Louis; Péter Bagossi
Novel macromolecular inhibitors of human immunodeficiency virus-1 protease.
Protein engineering, design & selection : PEDS 2008;21(7):453-61.
2008: JunGoo Jee; In-Ja L Byeon; John M Louis; Angela M Gronenborn
The point mutation A34F causes dimerization of GB1.
Proteins 2008;71(3):1420-31.
2008: Jane M Sayer; Fengling Liu; Rieko Ishima; Irene T Weber; John M Louis
Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease.
The Journal of biological chemistry 2008;283(19):13459-70.
2008: Rieko Ishima; John M Louis
A diverse view of protein dynamics from NMR studies of HIV-1 protease flaps.
Proteins 2008;70(4):1408-15.
2007: Andrey Yu Kovalevsky; Alexander A Chumanevich; Fengling Liu; John M Louis; Irene T Weber
Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate.
Biochemistry 2007;46(51):14854-64.
2007: Jordan H Chill; John M Louis; Frank Delaglio; Adriaan Bax
Local and global structure of the monomeric subunit of the potassium channel KcsA probed by NMR.
Biochimica et biophysica acta 2007;1768(12):3260-70.
2007: Elena Gustchina; John M Louis; Son N Lam; Carole A Bewley; G Marius Clore
A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.
Journal of virology 2007;81(23):12946-53.
2007: Rieko Ishima; Dennis A Torchia; John M Louis
Mutational and structural studies aimed at characterizing the monomer of HIV-1 protease and its precursor.
The Journal of biological chemistry 2007;282(23):17190-9.
2007: Mengli Cai; Ying Huang; Jeong-Yong Suh; John M Louis; Rodolfo Ghirlando; Robert Craigie; G Marius Clore
Solution NMR structure of the barrier-to-autointegration factor-Emerin complex.
The Journal of biological chemistry 2007;282(19):14525-35.
2007: Jinfa Ying; Jordan H Chill; John M Louis; Adriaan Bax
Mixed-time parallel evolution in multiple quantum NMR experiments: sensitivity and resolution enhancement in heteronuclear NMR.
Journal of biomolecular NMR 2007;37(3):195-204.
2007: Kusai A Merchant; Robert B Best; John M Louis; Irina V Gopich; William Eaton
Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1528-33.
2007: John M Louis; Rieko Ishima; Dennis A Torchia; Irene T Weber
HIV-1 protease: structure, dynamics, and inhibition.
Advances in pharmacology (San Diego, Calif.) 2007;55():261-98.
2006: Elena Gustchina; John M Louis; Carole A Bewley; G Marius Clore
Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.
Journal of molecular biology 2006;364(3):283-9.
2006: Andrey Yu Kovalevsky; Fengling Liu; Sofiya Leshchenko; Arun K Ghosh; John M Louis; Robert W Harrison; Irene T Weber
Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.
Journal of molecular biology 2006;363(1):161-73.
2006: Jordan H Chill; John M Louis; James L Baber; Adriaan Bax
Measurement of 15N relaxation in the detergent-solubilized tetrameric KcsA potassium channel.
Journal of biomolecular NMR 2006;36(2):123-36.
2006: Fengling Liu; Andrey Yu Kovalevsky; John M Louis; Peter I Boross; Yuan-Fang Wang; Robert W Harrison; Irene T Weber
Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.
Journal of molecular biology 2006;358(5):1191-9.
2006: Jordan H Chill; John M Louis; Christopher Miller; Adriaan Bax
NMR study of the tetrameric KcsA potassium channel in detergent micelles.
Protein science : a publication of the Protein Society 2006;15(4):684-98.
2005: Fengling Liu; Peter I Boross; Yuan-Fang Wang; Jozsef Tozser; John M Louis; Robert W Harrison; Irene T Weber
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
Journal of molecular biology 2005;354(4):789-800.
2005: John M Louis; Carole A Bewley; Elena Gustchina; Annie Aniana; G Marius Clore
Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41.
Journal of molecular biology 2005;353(5):945-51.
2005: John M Louis; In-Ja L Byeon; Ulrich Baxa; Angela M Gronenborn
The GB1 amyloid fibril: recruitment of the peripheral beta-strands of the domain swapped dimer into the polymeric interface.
Journal of molecular biology 2005;348(3):687-98.
2005: Elliott Gozansky; John M Louis; Michael Caffrey; G Marius Clore
Mapping the binding of the N-terminal extracellular tail of the CXCR4 receptor to stromal cell-derived factor-1alpha.
Journal of molecular biology 2005;345(4):651-8.
2004: In-Ja L Byeon; John M Louis; Angela M Gronenborn
A captured folding intermediate involved in dimerization and domain-swapping of GB1.
Journal of molecular biology 2004;340(3):615-25.
2004: Rieko Ishima; James L Baber; John M Louis; Dennis A Torchia
Carbonyl carbon transverse relaxation dispersion measurements and ms-micros timescale motion in a protein hydrogen bond network.
Journal of biomolecular NMR 2004;29(2):187-98.
2004: Yunfeng Tie; Peter I Boross; Yuan-Fang Wang; Laquasha Gaddis; Azhar K Hussain; Sofiya Leshchenko; Arun K Ghosh; John M Louis; Robert W Harrison; Irene T Weber
High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.
Journal of molecular biology 2004;338(2):341-52.
2004: József Tözsér; Sergey Shulenin; John M Louis; Terry D Copeland; Stephen Oroszlan
In vitro processing of HIV-1 nucleocapsid protein by the viral proteinase: effects of amino acid substitutions at the scissile bond in the proximal zinc finger sequence.
Biochemistry 2004;43(14):4304-12.
2004: Bhuvaneshwari Mahalingam; Yuan-Fang Wang; Peter I Boross; Jozsef Tozser; John M Louis; Robert W Harrison; Irene T Weber
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site.
European journal of biochemistry / FEBS 2004;271(8):1516-24.
2004: Keyang Ding; John M Louis; Angela M Gronenborn
Insights into conformation and dynamics of protein GB1 during folding and unfolding by NMR.
Journal of molecular biology 2004;335(5):1299-307.
2003: Rieko Ishima; Dennis A Torchia; Shannon M Lynch; Angela M Gronenborn; John M Louis
Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor.
The Journal of biological chemistry 2003;278(44):43311-9.
2003: In-Ja L Byeon; John M Louis; Angela M Gronenborn
A protein contortionist: core mutations of GB1 that induce dimerization and domain swapping.
Journal of molecular biology 2003;333(1):141-52.
2003: Etsuko Katoh; John M Louis; Toshimasa Yamazaki; Angela M Gronenborn; Dennis A Torchia; Rieko Ishima
A solution NMR study of the binding kinetics and the internal dynamics of an HIV-1 protease-substrate complex.
Protein science : a publication of the Protein Society 2003;12(7):1376-85.
2003: John M Louis; Issa Nesheiwat; LengChee Chang; G Marius Clore; Carole A Bewley
Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.
The Journal of biological chemistry 2003;278(22):20278-85.
2003: John M Louis; Rieko Ishima; Issa Nesheiwat; Lewis K Pannell; Shannon M Lynch; Dennis A Torchia; Angela M Gronenborn
Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties.
The Journal of biological chemistry 2003;278(8):6085-92.
2003: Laura G Barrientos; John M Louis; Daniel M Ratner; Peter H Seeberger; Angela M Gronenborn
Solution structure of a circular-permuted variant of the potent HIV-inactivating protein cyanovirin-N: structural basis for protein stability and oligosaccharide interaction.
Journal of molecular biology 2003;325(1):211-23.
2002: Jaison Jacob; John M Louis; Issa Nesheiwat; Dennis A Torchia
Biosynthetically directed fractional 13C labeling facilitates identification of Phe and Tyr aromatic signals in proteins.
Journal of biomolecular NMR 2002;24(3):231-5.
2002: Ramón Campos-Olivas; John M Louis; Danielle Clérot; Bruno Gronenborn; Angela M Gronenborn
1H, 13C, and 15N assignment of the N-terminal, catalytic domain of the replication initiation protein from the geminivirus TYLCV.
Journal of biomolecular NMR 2002;24(1):73-4.
2002: Ramón Campos-Olivas; John M Louis; Danielle Clerot; Bruno Gronenborn; Angela M Gronenborn
The structure of a replication initiator unites diverse aspects of nucleic acid metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10310-5.
2002: Anita Fehér; Irene T Weber; Péter Bagossi; Peter I Boross; Bhuvaneshwari Mahalingam; John M Louis; Terry D Copeland; Ivan Y Torshin; Robert W Harrison; József Tözsér
Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites.
European journal of biochemistry / FEBS 2002;269(16):4114-20.
2002: Bindi Dangi; Anatoliy Dobrodumov; John M Louis; Angela M Gronenborn
Solution structure and dynamics of the human-Escherichia coli thioredoxin chimera: insights into thermodynamic stability.
Biochemistry 2002;41(30):9376-88.
2002: Bhuvaneshwari Mahalingam; Peter I Boross; Yuan-Fang Wang; John M Louis; Christopher C Fischer; Jozsef Tozser; Robert W Harrison; Irene T Weber
Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins 2002;48(1):107-16.
2002: Laura G Barrientos; John M Louis; Istvan Botos; Toshiyuki Mori; Zhaozhong Han; Barry R O'Keefe; Michael R Boyd; Alexander Wlodawer; Angela M Gronenborn
The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.
Structure (London, England : 1993) 2002;10(5):673-86.
2002: Carole A Bewley; John M Louis; Rodolfo Ghirlando; G Marius Clore
Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41.
The Journal of biological chemistry 2002;277(16):14238-45.
2002: Demetrios T Braddock; John M Louis; James L Baber; David Levens; G Marius Clore
Structure and dynamics of KH domains from FBP bound to single-stranded DNA.
Nature 2002;415(6875):1051-6.
2002: Laura G Barrientos; John M Louis; Jason Hung; Trent H Smith; Barry R O'Keefe; Roberta S Gardella; Toshiyuki Mori; Michael R Boyd; Angela M Gronenborn
Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N.
Proteins 2002;46(2):153-60.
2002: Darón I Freedberg; Rieko Ishima; Jaison Jacob; Yun-Xing Wang; Irina Kustanovich; John M Louis; Dennis A Torchia
Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations.
Protein science : a publication of the Protein Society 2002;11(2):221-32.
2001: Rieko Ishima; R Ghirlando; J Tözsér; Angela M Gronenborn; Dennis A Torchia; John M Louis
Folded monomer of HIV-1 protease.
The Journal of biological chemistry 2001;276(52):49110-6.
2001: James J Chou; S Gaemers; B Howder; John M Louis; Adriaan Bax
A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micelles.
Journal of biomolecular NMR 2001;21(4):377-82.
2001: Bindi Dangi; P Pelupessey; Robert G Martin; Judah L Rosner; John M Louis; Angela M Gronenborn
Structure and dynamics of MarA-DNA complexes: an NMR investigation.
Journal of molecular biology 2001;314(1):113-27.
2001: Rieko Ishima; John M Louis; Dennis A Torchia
Optimized labeling of 13CHD2 methyl isotopomers in perdeuterated proteins: potential advantages for 13C relaxation studies of methyl dynamics of larger proteins.
Journal of biomolecular NMR 2001;21(2):167-71.
2001: Elizabeth C Murphy; Victor B Zhurkin; John M Louis; Gabriel Cornilescu; G Marius Clore
Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation.
Journal of molecular biology 2001;312(3):481-99.
2001: John M Louis; RE Georgescu; María Luisa Tasayco; O Tcherkasskaya; Angela M Gronenborn
Probing the structure and stability of a hybrid protein: the human-E. coli thioredoxin chimera.
Biochemistry 2001;40(37):11184-92.
2001: John M Louis; Carole A Bewley; G Marius Clore
Design and properties of N(CCG)-gp41, a chimeric gp41 molecule with nanomolar HIV fusion inhibitory activity.
The Journal of biological chemistry 2001;276(31):29485-9.
2001: Rieko Ishima; A P Petkova; John M Louis; Dennis A Torchia
Comparison of methyl rotation axis order parameters derived from model-free analyses of (2)H and (13)C longitudinal and transverse relaxation rates measured in the same protein sample.
Journal of the American Chemical Society 2001;123(25):6164-71.
2001: Bhuvaneshwari Mahalingam; John M Louis; J Hung; Robert W Harrison; Irene T Weber
Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins 2001;43(4):455-64.
2001: Laura G Barrientos; Ramón Campos-Olivas; John M Louis; András Fiser; Andrej Sali; Angela M Gronenborn
1H, 13C, 15N resonance assignments and fold verification of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N.
Journal of biomolecular NMR 2001;19(3):289-90.
2001: Laura G Barrientos; John M Louis; Angela M Gronenborn
Characterization of the cholesteric phase of filamentous bacteriophage fd for molecular alignment.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2001;149(1):154-8.
2001: Rieko Ishima; John M Louis; Dennis A Torchia
Characterization of two hydrophobic methyl clusters in HIV-1 protease by NMR spin relaxation in solution.
Journal of molecular biology 2001;305(3):515-21.
2000: József Tözsér; Gábor Zahuczky; Péter Bagossi; John M Louis; Terry D Copeland; Stephen Oroszlan; Robert W Harrison; Irene T Weber
Comparison of the substrate specificity of the human T-cell leukemia virus and human immunodeficiency virus proteinases.
European journal of biochemistry / FEBS 2000;267(20):6287-95.
2000: Michael Caffrey; Demetrios T Braddock; John M Louis; M A Abu-Asab; D Kingma; Lance A Liotta; M Tsokos; N Tresser; Lewis K Pannell; N Watts; Alasdair C Steven; Martha N Simon; Stephen J Stahl; Paul T Wingfield; G Marius Clore
Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia.
The Journal of biological chemistry 2000;275(26):19877-82.
2000: D Serio; Satya P Singh; Maria Cartas; Irene T Weber; Robert W Harrison; John M Louis; Alagarsamy Srinivasan
Antiviral agent based on the non-structural protein targeting the maturation process of HIV-1: expression and susceptibility of chimeric Vpr as a substrate for cleavage by HIV-1 protease.
Protein engineering 2000;13(6):431-6.
2000: Gábor Zahuczky; Peter I Boross; Péter Bagossi; G Emri; Terry D Copeland; Stephen Oroszlan; John M Louis; József Tözsér
Cloning of the bovine leukemia virus proteinase in Escherichia coli and comparison of its specificity to that of human T-cell leukemia virus proteinase.
Biochimica et biophysica acta 2000;1478(1):1-8.
2000: John M Louis; Irene T Weber; József Tözsér; G Marius Clore; Angela M Gronenborn
HIV-1 protease: maturation, enzyme specificity, and drug resistance.
Advances in pharmacology (San Diego, Calif.) 2000;49():111-46.
1999: József Tözsér; Péter Bagossi; Peter I Boross; John M Louis; Eva Majerova; Stephen Oroszlan; Terry D Copeland
Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.
European journal of biochemistry / FEBS 1999;265(1):423-9.
1999: Rieko Ishima; Darón I Freedberg; Yun-Xing Wang; John M Louis; Dennis A Torchia
Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function.
Structure (London, England : 1993) 1999;7(9):1047-55.
1999: Peter I Boross; Péter Bagossi; Terry D Copeland; Stephen Oroszlan; John M Louis; József Tözsér
Effect of substrate residues on the P2' preference of retroviral proteinases.
European journal of biochemistry / FEBS 1999;264(3):921-9.
1999: John M Louis; G Marius Clore; Angela M Gronenborn
Autoprocessing of HIV-1 protease is tightly coupled to protein folding.
Nature structural biology 1999;6(9):868-75.
1999: John M Louis; EM Wondrak; Alan R Kimmel; Paul T Wingfield; N T Nashed
Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism.
The Journal of biological chemistry 1999;274(33):23437-42.
1999: Bhuvaneshwari Mahalingam; John M Louis; Charles C Reed; JM Adomat; J Krouse; Yuan-Fang Wang; Robert W Harrison; Irene T Weber
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
European journal of biochemistry / FEBS 1999;263(1):238-45.
1999: John M Louis; Stephen Oroszlan; József Tözsér
Stabilization from autoproteolysis and kinetic characterization of the human T-cell leukemia virus type 1 proteinase.
The Journal of biological chemistry 1999;274(10):6660-6.
1999: Rieko Ishima; John M Louis; Dennis A Torchia
Transverse 1H cross relaxation in 1H-15N correlated 1H CPMG experiments.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1999;137(1):289-92.
1999: Angela M Gronenborn; G Marius Clore; John M Louis; Paul T Wingfield
Is human thioredoxin monomeric or dimeric?
Protein science : a publication of the Protein Society 1999;8(2):426-9.
1999: D Serio; Irene T Weber; Robert W Harrison; John M Louis; Alagarsamy Srinivasan
Epitope-based assay to determine the efficiency of cleavage by HIV-1 protease.
BioTechniques 1999;26(2):242-4, 246.
1998: J Wu; JM Adomat; todd ridky; John M Louis; Jonathan Leis; Robert W Harrison; Irene T Weber
Structural basis for specificity of retroviral proteases.
Biochemistry 1998;37(13):4518-26.
1998: John M Louis; Fred Dyda; N T Nashed; Alan R Kimmel; David Davies
Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.
Biochemistry 1998;37(8):2105-10.
1998: John M Louis; Robert G Martin; G Marius Clore; Angela M Gronenborn
Preparation of uniformly isotope-labeled DNA oligonucleotides for NMR spectroscopy.
The Journal of biological chemistry 1998;273(4):2374-8.
1997: Irene T Weber; J Wu; JM Adomat; Robert W Harrison; Alan R Kimmel; EM Wondrak; John M Louis
Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates.
European journal of biochemistry / FEBS 1997;249(2):523-30.
1997: József Tözsér; Péter Bagossi; Irene T Weber; John M Louis; Terry D Copeland; Stephen Oroszlan
Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity.
The Journal of biological chemistry 1997;272(27):16807-14.
1996: EM Wondrak; John M Louis
Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease.
Biochemistry 1996;35(39):12957-62.
1996: EM Wondrak; N T Nashed; M T Haber; Donald M Jerina; John M Louis
A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation.
The Journal of biological chemistry 1996;271(8):4477-81.
1995: G T Ginsburg; R Gollop; Y Yu; John M Louis; Charles Saxe; Alan R Kimmel
The regulation of Dictyostelium development by transmembrane signalling.
The Journal of eukaryotic microbiology 1995;42(3):200-5.
1994: EM Wondrak; Kazuyasu Sakaguchi; William G Rice; Ernest Kun; Alan R Kimmel; John M Louis
Removal of zinc is required for processing of the mature nucleocapsid protein of human immunodeficiency virus, type 1, by the viral protease.
The Journal of biological chemistry 1994;269(35):21948-50.
1994: John M Louis; G T Ginsburg; Alan R Kimmel
The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.
Genes & development 1994;8(17):2086-96.
1994: John M Louis; N T Nashed; K D Parris; Alan R Kimmel; Donald M Jerina
Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):7970-4.
1993: EM Wondrak; John M Louis; H de Rocquigny; J C Chermann; B P Roques
The gag precursor contains a specific HIV-1 protease cleavage site between the NC (P7) and P1 proteins.
FEBS letters 1993;333(1-2):21-4.
1993: John M Louis; Charles Saxe; Alan R Kimmel
Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):5969-73.
1993: Charles Saxe; G T Ginsburg; John M Louis; R Johnson; Peter N Devreotes; Alan R Kimmel
CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.
Genes & development 1993;7(2):262-72.
1992: József Tözsér; Irene T Weber; Alla Gustchina; I Bláha; T D Copeland; John M Louis; Stephen Oroszlan
Kinetic and modeling studies of S3-S3' subsites of HIV proteinases.
Biochemistry 1992;31(20):4793-800.
1991: John M Louis; R A McDonald; N T Nashed; EM Wondrak; Donald M Jerina; Stephen Oroszlan; P T Mora
Autoprocessing of the HIV-1 protease using purified wild-type and mutated fusion proteins expressed at high levels in Escherichia coli.
European journal of biochemistry / FEBS 1991;199(2):361-9.
1991: EM Wondrak; John M Louis; P T Mora; Stephen Oroszlan
Purification of HIV-1 wild-type protease and characterization of proteolytically inactive HIV-1 protease mutants by pepstatin A affinity chromatography.
FEBS letters 1991;280(2):347-50.
1991: EM Wondrak; John M Louis; Stephen Oroszlan
The effect of salt on the Michaelis Menten constant of the HIV-1 protease correlates with the Hofmeister series.
FEBS letters 1991;280(2):344-6.
1991: John M Louis; Stephen Oroszlan; P T Mora
Studies of the autoprocessing of the HIV-1 protease using cleavage site mutants.
Advances in experimental medicine and biology 1991;306():499-502.
1990: EM Wondrak; T D Copeland; John M Louis; Stephen Oroszlan
A solid phase assay for the protease of human immunodeficiency virus.
Analytical biochemistry 1990;188(1):82-5.
1989: John M Louis; C A Smith; EM Wondrak; P T Mora; Stephen Oroszlan
Substitution mutations of the highly conserved arginine 87 of HIV-1 protease result in loss of proteolytic activity.
Biochemical and biophysical research communications 1989;164(1):30-8.
1989: N T Nashed; John M Louis; Jane M Sayer; EM Wondrak; P T Mora; Stephen Oroszlan; Donald M Jerina
Continuous spectrophotometric assay for retroviral proteases of HIV-1 and AMV.
Biochemical and biophysical research communications 1989;163(2):1079-85.
1989: John M Louis; EM Wondrak; T D Copeland; C A Smith; P T Mora; Stephen Oroszlan
Chemical synthesis and expression of the HIV-1 protease gene in E. coli.
Biochemical and biophysical research communications 1989;159(1):87-94.
1988: John M Louis; V W McFarland; P May; P T Mora
The phosphoprotein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates.
Biochimica et biophysica acta 1988;950(3):395-402.