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Karim Lounes

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Karim C Lounes; Borries Demeler; David E Anderson; Aldrin Gomes; James D Potter; Rashid Nassar; Page A W Anderson
Cardiac troponin T forms a tetramer in vitro.
Michael S Kostelansky; Karim C Lounes; Li Fang Ping; Sarah K Dickerson; Oleg V Gorkun; Susan T Lord
Probing the gamma2 calcium-binding site: studies with gammaD298,301A fibrinogen reveal changes in the gamma294-301 loop that alter the integrity of the "a" polymerization site.
Susan E Wilhelm; Karim C Lounes; Susan T Lord
Investigation of residues in the fibrin(ogen) gamma chain involved in tissue plasminogen activator binding and plasminogen activation.

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2008: Karim C Lounes; Borries Demeler; David E Anderson; Aldrin Gomes; James D Potter; Rashid Nassar; Page A W Anderson
Cardiac troponin T forms a tetramer in vitro.
Biochemistry 2008;47(7):1970-6.
2007: Michael S Kostelansky; Karim C Lounes; Li Fang Ping; Sarah K Dickerson; Oleg V Gorkun; Susan T Lord
Probing the gamma2 calcium-binding site: studies with gammaD298,301A fibrinogen reveal changes in the gamma294-301 loop that alter the integrity of the "a" polymerization site.
Biochemistry 2007;46(17):5114-23.
2004: Susan E Wilhelm; Karim C Lounes; Susan T Lord
Investigation of residues in the fibrin(ogen) gamma chain involved in tissue plasminogen activator binding and plasminogen activation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2004;15(6):451-61.
2004: Phil Lefebvre; Pauline T Velasco; Amy Dear; Karim C Lounes; Susan T Lord; Stephen O Brennan; David Green; Laszlo Lorand
Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AalphaIVS4 + 1G>T mutation and an AalphaGln328 truncation (fibrinogen Keokuk).
Blood 2004;103(7):2571-6.
2004: Michael S Kostelansky; Karim C Lounes; Li Fang Ping; Sarah K Dickerson; Oleg V Gorkun; Susan T Lord
Calcium-binding site beta 2, adjacent to the "b" polymerization site, modulates lateral aggregation of protofibrils during fibrin polymerization.
Biochemistry 2004;43(9):2475-83.
2002: Jasper A Remijn; Martin J W IJsseldijk; Bettien M van Hemel; Dennis K Galanakis; Kelly A Hogan; Karim C Lounes; Susan T Lord; Jan J Sixma; Philip G de Groot
Reduced platelet adhesion in flowing blood to fibrinogen by alterations in segment gamma316-322, part of the fibrin-specific region.
British journal of haematology 2002;117(3):650-7.
2002: Karim C Lounes; Li Fang Ping; Oleg V Gorkun; Susan T Lord
Analysis of engineered fibrinogen variants suggests that an additional site mediates platelet aggregation and that "B-b" interactions have a role in protofibril formation.
Biochemistry 2002;41(16):5291-9.
2001: Karim C Lounes; Jerry B Lefkowitz; AH Henschen-Edman; AI Coates; Roy R Hantgan; Susan T Lord
The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.
Blood 2001;98(3):661-6.
2001: Jasper A Remijn; Karim C Lounes; Kelly A Hogan; Susan T Lord; Dennis K Galanakis; Jan J Sixma; Philip G de Groot
Mutations on fibrinogen (gamma 316-322) are associated with reduction in platelet adhesion under flow conditions.
Annals of the New York Academy of Sciences 2001;936():444-8.
2001: Karim C Lounes; Nobuo Okumura; Kelly A Hogan; Li Fang Ping; Susan T Lord
Polymerization site a function dependence on structural integrity of its nearby calcium binding site.
Annals of the New York Academy of Sciences 2001;936():205-9.
2001: Karim C Lounes; Jerry B Lefkowitz; AI Coates; Roy R Hantgan; AH Henschen-Edman; Susan T Lord
Fibrinogen Longmont. A heterozygous abnormal fibrinogen with B beta Arg-166 to Cys substitution associated with defective fibrin polymerization.
Annals of the New York Academy of Sciences 2001;936():129-32.
2000: Kelly A Hogan; Oleg V Gorkun; Karim C Lounes; AI Coates; John W Weisel; Roy R Hantgan; Susan T Lord
Recombinant fibrinogen Vlissingen/Frankfurt IV. The deletion of residues 319 and 320 from the gamma chain of firbinogen alters calcium binding, fibrin polymerization, cross-linking, and platelet aggregation.
The Journal of biological chemistry 2000;275(23):17778-85.