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Karen Lounsbury

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Tamara F Williams; Christopher S Francklyn; Adam C Mirando; Barrie Wilkinson; Karen M Lounsbury
Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.
Jessica M Cassavaugh; Sarah A Hale; Alan K Howe; Theresa L Wellman; Cheung Wong; Karen M Lounsbury
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
Nels Olson; Nicholas H Heintz; Milena Hristova; Karen M Lounsbury; Albert van der Vliet
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.

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All Publications

2013: Tamara F Williams; Christopher S Francklyn; Adam C Mirando; Barrie Wilkinson; Karen M Lounsbury
Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.
Scientific reports 2013;3():1317.
2011: Jessica M Cassavaugh; Sarah A Hale; Alan K Howe; Theresa L Wellman; Cheung Wong; Karen M Lounsbury
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
Journal of cellular biochemistry 2011;112(12):3882-90.
2011: Nels Olson; Nicholas H Heintz; Milena Hristova; Karen M Lounsbury; Albert van der Vliet
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
American journal of physiology. Lung cellular and molecular physiology 2011;301(6):L993-L1002.
2011: Jessica Cassavaugh; Karen M Lounsbury
Hypoxia-mediated biological control.
Journal of cellular biochemistry 2011;112(3):735-44.
2009: SA Buder-Hoffmann; Arti Shukla; Trisha F Barrett; Maximmilian MacPherson; Karen M Lounsbury; Brooke T Mossman
A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos.
The American journal of pathology 2009;174(2):449-59.
2008: Peter F Bove; Milena Hristova; Umadevi V Wesley; Nels Olson; Karen M Lounsbury; Albert van der Vliet
Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha.
The Journal of biological chemistry 2008;283(26):17919-28.
2008: Karen M Lounsbury
Preventing stenosis by local inhibition of KCa3.1: a finger on the phenotypic switch.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(6):1036-8.
2008: Christy A Barlow; Kajorn Kitiphongspattana; Nazli Siddiqui; Michael W Roe; Brooke T Mossman; Karen M Lounsbury
Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells.
Apoptosis : an international journal on programmed cell death 2008;13(5):681-92.
2008: Patricia Rose; Jeffrey Bond; Scott Tighe; Michael J Toth; Theresa L Wellman; Eva Maria Briso de Montiano; Martin M LeWinter; Karen M Lounsbury
Genes overexpressed in cerebral arteries following salt-induced hypertensive disease are regulated by angiotensin II, JunB, and CREB.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H1075-85.
2007: Christy A Barlow; Trisha F Barrett; Arti Shukla; Brooke T Mossman; Karen M Lounsbury
Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.
American journal of physiology. Lung cellular and molecular physiology 2007;292(6):L1361-9.
2007: Ketki M Hatle; Wendy Neveu; Oliver Dienz; Stacia Rymarchyk; Ramiro Barrantes; Sarah Hale; Nicholas Farley; Karen M Lounsbury; Jeffrey P Bond; Douglas J Taatjes; Mercedes Rincón
Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression.
Molecular and cellular biology 2007;27(8):2952-66.
2007: Arti Shukla; Karen M Lounsbury; Trisha F Barrett; Joanna Gell; Mercedes Rincon; Kelly J Butnor; Douglas J Taatjes; Gerald S Davis; Pamela M Vacek; Keiichi I Nakayama; Keiko Nakayama; Chad Steele; Brooke T Mossman
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.
The American journal of pathology 2007;170(1):140-51.
2006: Renee A Pulver-Kaste; Christy A Barlow; Jeffery Bond; Anjanette Watson; Paul L Penar; Bruce I Tranmer; Karen M Lounsbury
Ca2+ source-dependent transcription of CRE-containing genes in vascular smooth muscle.
American journal of physiology. Heart and circulatory physiology 2006;291(1):H97-105.
2006: Brooke T Mossman; Karen M Lounsbury; SEKHAR POTHIREDDY
Oxidants and signaling by mitogen-activated protein kinases in lung epithelium.
American journal of respiratory cell and molecular biology 2006;34(6):666-9.
2006: Arti Shukla; Trisha F Barrett; Keiichi I Nakayama; Kieko Nakayama; Brooke T Mossman; Karen M Lounsbury
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):997-9.
2006: Sarah A Hale; Cheung Wong; Karen M Lounsbury
Erythropoietin disrupts hypoxia-inducible factor signaling in ovarian cancer cells.
Gynecologic oncology 2006;100(1):14-9.
2006: Christy A Barlow; Patricia Rose; Renee A Pulver-Kaste; Karen M Lounsbury
Excitation-transcription coupling in smooth muscle.
The Journal of physiology 2006;570(Pt 1):59-64.
2006: Christy A Barlow; Arti Shukla; Brooke T Mossman; Karen M Lounsbury
Oxidant-mediated cAMP response element binding protein activation: calcium regulation and role in apoptosis of lung epithelial cells.
American journal of respiratory cell and molecular biology 2006;34(1):7-14.
2005: Andrew C Stanley; Karen M Lounsbury; Kim Corrow; Peter W Callas; Rima Zhar; Alan K Howe; Michael A Ricci
Pressure elevation slows the fibroblast response to wound healing.
Journal of vascular surgery 2005;42(3):546-51.
2005: Andrew C Stanley; Nathanial N Fernandez; Karen M Lounsbury; Kim Corrow; Turner M Osler; Christopher Healey; Patrick Forgione; Steven R Shackford; Michael A Ricci
Pressure-induced cellular senescence: a mechanism linking venous hypertension to venous ulcers.
The Journal of surgical research 2005;124(1):112-7.
2004: Karina Ckless; Niki L Reynaert; Douglas J Taatjes; Karen M Lounsbury; Albert van der Vliet; Yvonne M W Janssen-Heininger
In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2004;11(3):216-27.
2004: Arti Shukla; Trisha Flanders; Karen M Lounsbury; Brooke T Mossman
The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity.
Cancer research 2004;64(21):7780-6.
2004: Renee A Pulver; Patricia Rose-Curtis; Michael W Roe; George C Wellman; Karen M Lounsbury
Store-operated Ca2+ entry activates the CREB transcription factor in vascular smooth muscle.
Circulation research 2004;94(10):1351-8.
2004: Theresa L Wellman; Joshua Jenkins; Paul L Penar; Bruce I Tranmer; Rima Zahr; Karen M Lounsbury
Nitric oxide and reactive oxygen species exert opposing effects on the stability of hypoxia-inducible factor-1alpha (HIF-1alpha) in explants of human pial arteries.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):379-81.
2003: Cheung Wong; Theresa L Wellman; Karen M Lounsbury
VEGF and HIF-1alpha expression are increased in advanced stages of epithelial ovarian cancer.
Gynecologic oncology 2003;91(3):513-7.
2003: Christopher Healey; Patrick Forgione; Karen M Lounsbury; Kim Corrow; Turner M Osler; Michael A Ricci; Andrew Stanley
A new in vitro model of venous hypertension: the effect of pressure on dermal fibroblasts.
Journal of vascular surgery 2003;38(5):1099-105.
2003: Arti Shukla; Maria Stern; Karen M Lounsbury; Trisha Flanders; Brooke T Mossman
Asbestos-induced apoptosis is protein kinase C delta-dependent.
American journal of respiratory cell and molecular biology 2003;29(2):198-205.
2002: Karen M Lounsbury; Maria Stern; Douglas J Taatjes; Susan Jaken; Brooke T Mossman
Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos.
The American journal of pathology 2002;160(6):1991-2000.
2001: Andra S Stevenson; L Cartin; Theresa L Wellman; M H Dick; Mark T Nelson; Karen M Lounsbury
Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells.
Experimental cell research 2001;263(1):118-30.
2000: Karen M Lounsbury; Qinghua Hu; Roy C Ziegelstein
Calcium signaling and oxidant stress in the vasculature.
Free radical biology & medicine 2000;28(9):1362-9.
2000: L Cartin; Karen M Lounsbury; Mark T Nelson
Coupling of Ca(2+) to CREB activation and gene expression in intact cerebral arteries from mouse : roles of ryanodine receptors and voltage-dependent Ca(2+) channels.
Circulation research 2000;86(7):760-7.
1999: Harry Knot; Karen M Lounsbury; Joseph E Brayden; Mark T Nelson
Gender differences in coronary artery diameter reflect changes in both endothelial Ca2+ and ecNOS activity.
The American journal of physiology 1999;276(3 Pt 2):H961-9.
1997: Karen M Lounsbury; I G Macara
Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta.
The Journal of biological chemistry 1997;272(1):551-5.
1996: Karen M Lounsbury; S A Richards; Kimberly L Carey; Ian G Macara
Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization.
The Journal of biological chemistry 1996;271(51):32834-41.
1996: S A Richards; Karen M Lounsbury; Kimberly L Carey; Ian G Macara
A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.
The Journal of cell biology 1996;134(5):1157-68.
1996: Kimberly L Carey; S A Richards; Karen M Lounsbury; Ian G Macara
Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import.
The Journal of cell biology 1996;133(5):985-96.
1996: Ian G Macara; Karen M Lounsbury; S A Richards; C McKiernan; D Bar-Sagi
The Ras superfamily of GTPases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(5):625-30.
1996: Karen M Lounsbury; S A Richards; R R Perlungher; Ian G Macara
Ran binding domains promote the interaction of Ran with p97/beta-karyopherin, linking the docking and translocation steps of nuclear import.
The Journal of biological chemistry 1996;271(5):2357-60.
1995: S A Richards; Karen M Lounsbury; Ian G Macara
The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1.
The Journal of biological chemistry 1995;270(24):14405-11.
1994: Karen M Lounsbury; A L Beddow; Ian G Macara
A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation.
The Journal of biological chemistry 1994;269(15):11285-90.