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Timothy Lovenberg

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Li Zhang; Xiaohu Deng; Chester Kuei; Timothy W Lovenberg; Neelakandha S Mani; Taraneh Mirzadegan; Amy Y Shih; Siquan Sun; Jiejun Wu; Xia V Yang; Changlu Liu
Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.
Pascal Bonaventure; Nicholas I Carruthers; Wenying Chai; Peter De Boer; Jianing Di; Wilhelmus Drinkenburg; Christine Dugovic; Curt A Dvorak; Lisa Dvorak; Ian Fraser; Michelle Kramer; Brian Lord; Diane Nepomuceno; Steve Sands; Jonathan Shelton; Jaskaran Singh; Sue Wilson; Abdellah Ahnaou; Leah Aluisio; Kirk Bertelsen; Timothy W Lovenberg
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.
Changlu Liu; Nicholas Carruthers; Margery A Connelly; Chester Kuei; Grace Lee; Taraneh Mirzadegan; Jonathan Shelton; Amy Shih; Steven Sutton; Jiejun Wu; Jingxue Yu; Li Zhang; Jessica Zhu; Timothy W Lovenberg
3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes.

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All Publications

2012: Li Zhang; Xiaohu Deng; Chester Kuei; Timothy W Lovenberg; Neelakandha S Mani; Taraneh Mirzadegan; Amy Y Shih; Siquan Sun; Jiejun Wu; Xia V Yang; Changlu Liu
Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.
Molecular pharmacology 2012;82(6):1094-103.
2012: Pascal Bonaventure; Nicholas I Carruthers; Wenying Chai; Peter De Boer; Jianing Di; Wilhelmus Drinkenburg; Christine Dugovic; Curt A Dvorak; Lisa Dvorak; Ian Fraser; Michelle Kramer; Brian Lord; Diane Nepomuceno; Steve Sands; Jonathan Shelton; Jaskaran Singh; Sue Wilson; Abdellah Ahnaou; Leah Aluisio; Kirk Bertelsen; Timothy W Lovenberg
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.
The Journal of pharmacology and experimental therapeutics 2012;342(2):429-40.
2012: Changlu Liu; Nicholas Carruthers; Margery A Connelly; Chester Kuei; Grace Lee; Taraneh Mirzadegan; Jonathan Shelton; Amy Shih; Steven Sutton; Jiejun Wu; Jingxue Yu; Li Zhang; Jessica Zhu; Timothy W Lovenberg
3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes.
The Journal of pharmacology and experimental therapeutics 2012;341(3):794-801.
2011: Devin M Swanson; Victoria D Wong; John R Atack; Pascal Bonaventure; Curt A Dvorak; Lisa K Dvorak; JIll Jablonowski; Timothy W Lovenberg; Kirsten Morton; Diane Nepomuceno; Dale A Rudolph; Mark Seierstad; Chandra Shah; Nicholas I Carruthers
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.
Bioorganic & medicinal chemistry letters 2011;21(18):5552-6.
2011: Andrea Cippitelli; Lindsay Eisenberg; Markus Heilig; Edward D Levin; Timothy W Lovenberg; S Timothy Motley; Amir H Rezvani; J Elliott Robinson; Pascal Bonaventure; Annika Thorsell
The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.
Alcohol (Fayetteville, N.Y.) 2011;45(6):567-76.
2011: Changlu Liu; Homayon Banie; Lars Karlsson; Chester Kuei; Neelakandha S Mani; Ning Qin; Siquan Sun; Steven W Sutton; Jiejun Wu; Xia V Yang; Jingxue Yu; Li Zhang; Timothy W Lovenberg
Oxysterols direct B-cell migration through EBI2.
Nature 2011;475(7357):519-23.
2011: James R Shoblock; Natalie Welty; Leah Aluisio; Ian Fraser; S Timothy Motley; Kirsten Morton; James Palmer; Pascal Bonaventure; Nicholas I Carruthers; Timothy W Lovenberg; Jamin Boggs; Ruggero Galici
Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement.
Psychopharmacology 2011;215(1):191-203.
2011: Ruggero Galici; Amir H Rezvani; Leah Aluisio; Brian Lord; Edward D Levin; Ian Fraser; Jamin Boggs; Natalie Welty; James R Shoblock; S Timothy Motley; Michael A Letavic; Nicholas I Carruthers; Christine Dugovic; Timothy W Lovenberg; Pascal Bonaventure
JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.
Psychopharmacology 2011;214(4):829-41.
2011: Pascal Bonaventure; Ian C Fraser; Leah Aluisio; Jamin D Boggs; Brian Lord; Timothy W Lovenberg; James R Shoblock; Ruggero Galici
Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.
PloS one 2011;6(6):e20210.
2011: Dale A Rudolph; Curt A Dvorak; Lisa Dvorak; Diane Nepomuceno; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.
Bioorganic & medicinal chemistry letters 2011;21(1):42-4.
2010: Alejandro Santillan; Kelly J McClure; Brett D Allison; Brian Lord; Jamin D Boggs; Kirsten L Morton; Anita M Everson; Diane Nepomuceno; Michael A Letavic; Alice Lee-Dutra; Timothy W Lovenberg; Nicholas I Carruthers; Cheryl A Grice
Indole- and benzothiophene-based histamine H3 antagonists.
Bioorganic & medicinal chemistry letters 2010;20(21):6226-30.
2010: Michael A Letavic; Leah Aluisio; John R Atack; Pascal Bonaventure; Nicholas I Carruthers; Christine Dugovic; Anita Everson; Mark A Feinstein; Ian C Fraser; Kenway Hoey; Xiaohui Jiang; John M Keith; Tatiana Koudriakova; Perry Leung; Brian Lord; Timothy W Lovenberg; Kiev S Ly; Kirsten L Morton; S Timothy Motley; Diane Nepomuceno; Michele Rizzolio; Raymond Rynberg; Kia Sepassi; Jonathan Shelton
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorganic & medicinal chemistry letters 2010;20(14):4210-4.
2010: Diane Nepomuceno; Steve Sutton; Jingxue Yu; Jessica Zhu; Changlu Liu; Timothy W Lovenberg; Pascal Bonaventure
Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor.
European journal of pharmacology 2010;635(1-3):27-33.
2010: James R Shoblock; Natalie Welty; Diane Nepomuceno; Brian Lord; Leah Aluisio; Ian Fraser; S Timothy Motley; Steve W Sutton; Kirsten Morton; Ruggero Galici; John R Atack; Lisa Dvorak; Devin M Swanson; Nicholas I Carruthers; Curt Dvorak; Timothy W Lovenberg; Pascal Bonaventure
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.
Psychopharmacology 2010;208(2):265-77.
2009: Devin M Swanson; Chandra R Shah; Brian Lord; Kirsten Morton; Lisa K Dvorak; Curt Mazur; Richard Apodaca; Wei Xiao; Jamin D Boggs; Mark Feinstein; Sandy J Wilson; Ann J Barbier; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.
European journal of medicinal chemistry 2009;44(11):4413-25.
2009: Curt A Dvorak; Richard Apodaca; Wei Xiao; JIll Jablonowski; Pascal Bonaventure; Christine Dugovic; Jonathan Shelton; Brian Lord; Kirsten Miller; Lisa K Dvorak; Timothy W Lovenberg; Nicholas I Carruthers
Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.
European journal of medicinal chemistry 2009;44(10):4098-106.
2009: Christine Dugovic; Jonathan E Shelton; Leah E Aluisio; Ian C Fraser; Xiaohui Jiang; Steven W Sutton; Pascal Bonaventure; su jin yun; Xiaorong Li; Brian Lord; Curt A Dvorak; Nicholas I Carruthers; Timothy W Lovenberg
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.
The Journal of pharmacology and experimental therapeutics 2009;330(1):142-51.
2009: Ruggero Galici; Jamin D Boggs; Leah Aluisio; Ian C Fraser; Pascal Bonaventure; Brian Lord; Timothy W Lovenberg
JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.
Neuropharmacology 2009;56(8):1131-7.
2009: Steven W Sutton; Jonathan Shelton; Craig Smith; John Williams; su jin yun; Timothy Motley; Chester Kuei; Pascal Bonaventure; Andrew L Gundlach; Changlu Liu; Timothy W Lovenberg
Metabolic and neuroendocrine responses to RXFP3 modulation in the central nervous system.
Annals of the New York Academy of Sciences 2009;1160():242-9.
2009: Andrew L Gundlach; Sherie Ma; Qian Sang; Pei-Juan Shen; Loretta Piccenna; Katayoun Sedaghat; Craig M Smith; Ross A D Bathgate; Andrew J Lawrence; Geoffrey W Tregear; John D Wade; David Finkelstein; Pascal Bonaventure; Changlu Liu; Timothy W Lovenberg; Steven W Sutton
Relaxin family peptides and receptors in mammalian brain.
Annals of the New York Academy of Sciences 2009;1160():226-35.
2009: Changlu Liu; Chester Kuei; Steven Sutton; Jonathan Shelton; Jessica Zhu; Diane Nepomuceno; Mohammed Akhter Hossain; John D Wade; Ross A D Bathgate; Pascal Bonaventure; Timothy W Lovenberg
Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.
Annals of the New York Academy of Sciences 2009;1160():31-7.
2009: JIll Jablonowski; Kiev S Ly; Michael Bogenstaetter; Curt A Dvorak; Jamin D Boggs; Lisa K Dvorak; Brian Lord; Kirsten L Miller; Curt Mazur; Sandy J Wilson; Timothy W Lovenberg; Nicholas I Carruthers
Novel imidazole-based histamine H3 antagonists.
Bioorganic & medicinal chemistry letters 2009;19(3):903-7.
2009: Jonathan Shelton; Pascal Bonaventure; Xiaorong Li; su jin yun; Timothy W Lovenberg; Christine Dugovic
5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor.
Neuropharmacology 2009;56(2):448-54.
2009: Changlu Liu; Jiejun Wu; Jessica Zhu; Chester Kuei; Jingxue Yu; Jonathan Shelton; Steven W Sutton; Xiaorong Li; su jin yun; Taraneh Mirzadegan; Curt Mazur; Fredrik Kamme; Timothy W Lovenberg
Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.
The Journal of biological chemistry 2009;284(5):2811-22.
2008: Jessica Zhu; Chester Kuei; Steven Sutton; Fredrik Kamme; Jingxue Yu; Pascal Bonaventure; John R Atack; Timothy W Lovenberg; Changlu Liu
Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135).
European journal of pharmacology 2008;590(1-3):43-52.
2008: Leah Aluisio; Brian Lord; Ann J Barbier; Ian C Fraser; Sandy J Wilson; Jamin D Boggs; Lisa K Dvorak; Michael A Letavic; Bruce E Maryanoff; Nicholas I Carruthers; Pascal Bonaventure; Timothy W Lovenberg
In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
European journal of pharmacology 2008;587(1-3):141-6.
2008: Brock T Shireman; Curt A Dvorak; Dale A Rudolph; Pascal Bonaventure; Diane Nepomuceno; Lisa Dvorak; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
Bioorganic & medicinal chemistry letters 2008;18(6):2103-8.
2008: Scott D Bembenek; John M Keith; Michael A Letavic; Richard Apodaca; Ann J Barbier; Lisa Dvorak; Leah Aluisio; Kirsten L Miller; Timothy W Lovenberg; Nicholas I Carruthers
Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Bioorganic & medicinal chemistry 2008;16(6):2968-73.
2008: Changlu Liu; Timothy W Lovenberg
Relaxin-3, INSL5, and their receptors.
Results and problems in cell differentiation 2008;46():213-37.
2007: Ann J Barbier; Leah Aluisio; Brian Lord; Ying Qu; Sandy J Wilson; Jamin D Boggs; Pascal Bonaventure; Kirsten Miller; Ian Fraser; Lisa Dvorak; Cindy Pudiak; Christine Dugovic; Jonathan Shelton; Curt Mazur; Michael A Letavic; Nicholas I Carruthers; Timothy W Lovenberg
Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.
European journal of pharmacology 2007;576(1-3):43-54.
2007: John M Keith; Ann J Barbier; Sandy J Wilson; Kirstin Miller; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.
Bioorganic & medicinal chemistry letters 2007;17(19):5325-9.
2007: Chester Kuei; Steven Sutton; Pascal Bonaventure; Cindy Pudiak; Jonathan Shelton; Jessica Zhu; Diane Nepomuceno; Jiejun Wu; Jingcai Chen; Fredrik Kamme; Mark Seierstad; Michael D Hack; Ross A D Bathgate; Mohammed Akhter Hossain; John D Wade; John Atack; Timothy W Lovenberg; Changlu Liu
R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.
The Journal of biological chemistry 2007;282(35):25425-35.
2007: John M Keith; Leslie A Gomez; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Brian Lord; Curt Mazur; Leah Aluisio; Timothy W Lovenberg; Nicholas I Carruthers
Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(15):4374-7.
2007: Emily M Stocking; Jennifer M Miller; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Heather M McAllister; Jiejun Wu; Timothy W Lovenberg; Nicholas I Carruthers; Ronald L Wolin
Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
Bioorganic & medicinal chemistry letters 2007;17(11):3130-5.
2007: John M Keith; Leslie A Gomez; Ronald L Wolin; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Curt Mazur; Ian C Fraser; Brian Lord; Leah Aluisio; Timothy W Lovenberg; Nicholas I Carruthers
Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2603-7.
2007: Pascal Bonaventure; Lisa Kelly; Leah Aluisio; Jonathan Shelton; Brian Lord; Ruggero Galici; Kirsten Miller; John Atack; Timothy W Lovenberg; Christine Dugovic
Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents.
The Journal of pharmacology and experimental therapeutics 2007;321(2):690-8.
2007: Michael A Letavic; John M Keith; Kiev S Ly; Ann J Barbier; Jamin D Boggs; Sandy J Wilson; Brian Lord; Timothy W Lovenberg; Nicholas I Carruthers
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2566-9.
2007: Pascal Bonaventure; Michael A Letavic; Christine Dugovic; S Wilson; Leah Aluisio; Cindy Pudiak; Brian Lord; Curt Mazur; Fredrik Kamme; S Nishino; Nicholas I Carruthers; Timothy W Lovenberg
Histamine H3 receptor antagonists: from target identification to drug leads.
Biochemical pharmacology 2007;73(8):1084-96.
2007: Michael A Letavic; John M Keith; JIll Jablonowski; Emily M Stocking; Leslie A Gomez; Kiev S Ly; Jennifer M Miller; Ann J Barbier; Pascal Bonaventure; Jamin D Boggs; Sandy J Wilson; Kirsten L Miller; Brian Lord; Heather M McAllister; D J Tognarelli; Jiejun Wu; Marta C Abad; Carsten Schubert; Timothy W Lovenberg; Nicholas I Carruthers
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(4):1047-51.
2007: John M Keith; Leslie A Gomez; Michael A Letavic; Kiev S Ly; JIll Jablonowski; Mark Seierstad; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Ian C Fraser; Curt Mazur; Timothy W Lovenberg; Nicholas I Carruthers
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Bioorganic & medicinal chemistry letters 2007;17(3):702-6.
2006: Feiyong Jia; Motohisa Kato; Hongmei Dai; Ajing Xu; Tomohiro Okuda; Eiko Sakurai; Nobuyuki Okamura; Timothy W Lovenberg; Ann J Barbier; Nicholas I Carruthers; Kazuie Iinuma; Kazuhiko Yanai
Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Neuropharmacology 2006;50(4):404-11.
2006: Devin M Swanson; Sandy J Wilson; Jamin D Boggs; Wei Xiao; Richard Apodaca; Ann J Barbier; Timothy W Lovenberg; Nicholas I Carruthers
Aplysamine-1 and related analogs as histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(4):897-900.
2005: Jennifer D Venable; Hui Cai; Wenying Chai; Curt A Dvorak; Cheryl A Grice; JIll Jablonowski; Chandra R Shah; Annette K Kwok; Kiev S Ly; Barbara Pio; Jianmei Wei; Pragnya J Desai; Wendy Jiang; Steven Nguyen; Ping Ling; Sandy J Wilson; Paul J Dunford; Robin Thurmond; Timothy W Lovenberg; Lars Karlsson; Nicholas I Carruthers; James P Edwards
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Journal of medicinal chemistry 2005;48(26):8289-98.
2005: Elo Eriste; Ake Norberg; Diane Nepomuceno; Chester Kuei; Fredrik Kamme; Da-Thao Tran; Kerstin Strupat; Hans Jörnvall; Changlu Liu; Timothy W Lovenberg; Rannar Sillard
A novel form of neurotensin post-translationally modified by arginylation.
The Journal of biological chemistry 2005;280(42):35089-97.
2005: Jingcai Chen; Chester Kuei; Steven Sutton; Sandy Wilson; Jingxue Yu; Fredrik Kamme; Curt Mazur; Timothy W Lovenberg; Changlu Liu
Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
Molecular pharmacology 2005;67(6):2070-6.
2005: Changlu Liu; Pascal Bonaventure; Steven W Sutton; Jingcai Chen; Chester Kuei; Diane Nepomuceno; Timothy W Lovenberg
Recent progress in relaxin-3-related research.
Annals of the New York Academy of Sciences 2005;1041():47-60.
2005: Pascal Bonaventure; Diane Nepomuceno; Kirsten Miller; Jingcai Chen; Chester Kuei; Fredrik Kamme; Da-Thao Tran; Timothy W Lovenberg; Changlu Liu
Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog.
European journal of pharmacology 2005;513(3):181-92.
2005: Curt A Dvorak; Richard Apodaca; Ann J Barbier; Craig W Berridge; Sandy J Wilson; Jamin D Boggs; Wei Xiao; Timothy W Lovenberg; Nicholas I Carruthers
4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists.
Journal of medicinal chemistry 2005;48(6):2229-38.
2005: Changlu Liu; Chester Kuei; Steven Sutton; Jingcai Chen; Pascal Bonaventure; Jiejun Wu; Diane Nepomuceno; Fredrik Kamme; Da-Thao Tran; Jessica Zhu; Tracey Wilkinson; Ross A D Bathgate; Elo Eriste; Rannar Sillard; Timothy W Lovenberg
INSL5 is a high affinity specific agonist for GPCR142 (GPR100).
The Journal of biological chemistry 2005;280(1):292-300.
2005: Steven W Sutton; Pascal Bonaventure; Chester Kuei; Diane Nepomuceno; Jiejun Wu; Jessica Zhu; Timothy W Lovenberg; Changlu Liu
G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135.
Neuroendocrinology 2005;82(3-4):139-50.
2005: Changlu Liu; Jingcai Chen; Chester Kuei; Steven Sutton; Diane Nepomuceno; Pascal Bonaventure; Timothy W Lovenberg
Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.
Molecular pharmacology 2005;67(1):231-40.
2005: Jingcai Chen; Chester Kuei; Steven W Sutton; Pascal Bonaventure; Diane Nepomuceno; Elo Eriste; Rannar Sillard; Timothy W Lovenberg; Changlu Liu
Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species.
The Journal of pharmacology and experimental therapeutics 2005;312(1):83-95.
2004: Ann J Barbier; C Berridge; Christine Dugovic; Aaron D Laposky; Sandy J Wilson; Jamin D Boggs; Leah Aluisio; Brian Lord; Curt Mazur; Cindy Pudiak; Xavier Langlois; Wei Xiao; Richard Apodaca; Nicholas I Carruthers; Timothy W Lovenberg
Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.
British journal of pharmacology 2004;143(5):649-61.
2004: Laura C McAtee; Steven W Sutton; Dale A Rudolph; Xiaobing Li; Leah Aluisio; Victor K Phuong; Curt A Dvorak; Timothy W Lovenberg; Nicholas I Carruthers; Todd K Jones
Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(16):4225-9.
2004: Ronald L Wolin; Alejandro Santillán; Liu Tang; Charles Huang; Xiaoxia Jiang; Timothy W Lovenberg
Inhibitors of the glycine transporter type-2 (GlyT-2): synthesis and biological activity of benzoylpiperidine derivatives.
Bioorganic & medicinal chemistry 2004;12(16):4511-32.
2004: Ronald L Wolin; Alejandro Santillán; Tristin Barclay; Liu Tang; Hariharan Venkatesan; Sandy Wilson; Doo H Lee; Timothy W Lovenberg
Novel glycine transporter type-2 reuptake inhibitors. Part 2: beta- and gamma-amino acid derivatives.
Bioorganic & medicinal chemistry 2004;12(16):4493-509.
2004: Ronald L Wolin; Hariharan Venkatesan; Liu Tang; Alejandro Santillán; Tristin Barclay; Sandy Wilson; Doo H Lee; Timothy W Lovenberg
Novel glycine transporter type-2 reuptake inhibitors. Part 1: alpha-amino acid derivatives.
Bioorganic & medicinal chemistry 2004;12(16):4477-92.
2004: Peter B Hedlund; Lisa Kelly; Curt Mazur; Timothy W Lovenberg; J Gregor Sutcliffe; Pascal Bonaventure
8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents.
European journal of pharmacology 2004;487(1-3):125-32.
2004: JIll Jablonowski; Wenying Chai; Xiaobing Li; Dale A Rudolph; William V Murray; Mark A Youngman; Scott L Dax; Diane Nepomuceno; Pascal Bonaventure; Timothy W Lovenberg; Nicholas I Carruthers
Novel non-peptidic neuropeptide Y Y2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(5):1239-42.
2004: Pascal Bonaventure; Diane Nepomuceno; Curt Mazur; Brian Lord; Dale A Rudolph; JIll Jablonowski; Nicholas I Carruthers; Timothy W Lovenberg
Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1130-7.
2004: Steven W Sutton; Pascal Bonaventure; Chester Kuei; Barbara Roland; Jingcai Chen; Diane Nepomuceno; Timothy W Lovenberg; Changlu Liu
Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.
Neuroendocrinology 2004;80(5):298-307.
2004: Pascal Bonaventure; Diane Nepomuceno; L Hein; J Gregor Sutcliffe; Timothy W Lovenberg; Peter B Hedlund
Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors.
Neuroscience 2004;124(4):901-11.
2003: Changlu Liu; Elo Eriste; Steven Sutton; Jingcai Chen; Barbara Roland; Chester Kuei; Niven Farmer; Hans Jörnvall; Rannar Sillard; Timothy W Lovenberg
Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.
The Journal of biological chemistry 2003;278(50):50754-64.
2003: Changlu Liu; Jingcai Chen; Steven Sutton; Barbara Roland; Chester Kuei; Niven Farmer; Rannar Sillard; Timothy W Lovenberg
Identification of relaxin-3/INSL7 as a ligand for GPCR142.
The Journal of biological chemistry 2003;278(50):50765-70.
2003: JIll Jablonowski; Cheryl A Grice; Wenying Chai; Curt A Dvorak; Jennifer D Venable; Annette K Kwok; Kiev S Ly; Jianmei Wei; Sherry M Baker; Pragnya J Desai; Wendy Jiang; Sandy J Wilson; Robin Thurmond; Lars Karlsson; James P Edwards; Timothy W Lovenberg; Nicholas I Carruthers
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Journal of medicinal chemistry 2003;46(19):3957-60.
2003: Richard Apodaca; Curt A Dvorak; Wei Xiao; Ann J Barbier; Jamin D Boggs; Sandy J Wilson; Timothy W Lovenberg; Nicholas I Carruthers
A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.
Journal of medicinal chemistry 2003;46(18):3938-44.
2003: Sandy J Wilson; Timothy W Lovenberg; Ann J Barbier
A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase.
Analytical biochemistry 2003;318(2):270-5.
2003: Wenying Chai; J Guy Breitenbucher; Annette Kwok; Xiaobing Li; Victoria Wong; Nicholas I Carruthers; Timothy W Lovenberg; Curt Mazur; Sandy J Wilson; Frank U Axe; Todd K Jones
Non-imidazole heterocyclic histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(10):1767-70.
2003: Jingcai Chen; Changlu Liu; Timothy W Lovenberg
Molecular and pharmacological characterization of the mouse histamine H3 receptor.
European journal of pharmacology 2003;467(1-3):57-65.
2003: Motohiro Koyama; Nahid Seyedi; Wai-Ping Fung-Leung; Timothy W Lovenberg; Roberto Levi
Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors.
Molecular pharmacology 2003;63(2):378-82.
2002: Chandra Shah; Laura C McAtee; J Guy Breitenbucher; Dale A Rudolph; Xiaobing Li; Timothy W Lovenberg; Curt Mazur; Sandy J Wilson; Nicholas I Carruthers
Novel human histamine H(3) receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(22):3309-12.
2002: Hiroshi Toyota; Christine Dugovic; Muriel Koehl; Aaron D Laposky; China Weber; Karen Ngo; Ying Wu; Doo H Lee; Kazuhiko Yanai; Eiko Sakurai; Takehiko Watanabe; Changlu Liu; Jingcai Chen; Ann J Barbier; Fred W Turek; Wai-Ping Fung-Leung; Timothy W Lovenberg
Behavioral characterization of mice lacking histamine H(3) receptors.
Molecular pharmacology 2002;62(2):389-97.
2002: Thomas Krucker; George R Siggins; Robert K McNamara; Kristen A Lindsley; Alan Dao; David Allison; Luis de Lecea; Timothy W Lovenberg; J Gregor Sutcliffe; Dan Gerendasy
Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(13):5525-35.
2002: Pascal Bonaventure; Diane Nepomuceno; Annette Kwok; Wenying Chai; Xavier Langlois; René Hen; Kimberly Stark; Nicholas I Carruthers; Timothy W Lovenberg
Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice.
The Journal of pharmacology and experimental therapeutics 2002;302(1):240-8.
2002: Randi B Silver; Kumar S Poonwasi; Nahid Seyedi; Sandy J Wilson; Timothy W Lovenberg; Roberto Levi
Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):501-6.
2001: Changlu Liu; SJ Wilson; Chester Kuei; Timothy W Lovenberg
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation.
The Journal of pharmacology and experimental therapeutics 2001;299(1):121-30.
2001: Cheryl P Kordik; Chi Luo; B C Zanoni; Timothy W Lovenberg; SJ Wilson; Anil Vaidya; Jeffrey J Crooke; Daniel I Rosenthal; Allen B Reitz
Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity.
Bioorganic & medicinal chemistry letters 2001;11(17):2287-90.
2001: Cheryl P Kordik; Chi Luo; B C Zanoni; Scott L Dax; James J McNally; Timothy W Lovenberg; SJ Wilson; Allen B Reitz
Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor.
Bioorganic & medicinal chemistry letters 2001;11(17):2283-6.
2001: Z Chen; Elo Eriste; AP Jonsson; Ake Norberg; Diane Nepomuceno; Timothy W Lovenberg; Tomas Bergman; S Efendic; Hans Jörnvall; Rannar Sillard
Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity.
FEBS letters 2001;492(1-2):119-22.
2001: Changlu Liu; X Ma; X Jiang; SJ Wilson; C L Hofstra; J Blevitt; J Pyati; X Li; W Chai; Nicholas I Carruthers; Timothy W Lovenberg
Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
Molecular pharmacology 2001;59(3):420-6.
2001: Randi B Silver; Christina J Mackins; N C Smith; I L Koritchneva; K Lefkowitz; Timothy W Lovenberg; Roberto Levi
Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2855-9.
2000: C Liu; X J Ma; Timothy W Lovenberg
Alternative splicing of the histamine H(3) receptor mRNA at the third cytoplasmic loop is not detectable in humans.
Brain research. Molecular brain research 2000;83(1-2):145-50.
2000: James J McNally; Mark A Youngman; Timothy W Lovenberg; Diane Nepomuceno; S Wilson; Scott L Dax
N-acylated alpha-(3-pyridylmethyl)-beta-aminotetralin antagoinists of the human neuropeptide Y Y5 receptor.
Bioorganic & medicinal chemistry letters 2000;10(15):1641-3.
2000: Timothy W Lovenberg; J Pyati; H Chang; SJ Wilson; Mark G Erlander
Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.
The Journal of pharmacology and experimental therapeutics 2000;293(3):771-8.
2000: Mark A Youngman; James J McNally; Timothy W Lovenberg; Allen B Reitz; N M Willard; Diane Nepomuceno; SJ Wilson; Jeffrey J Crooke; Daniel Rosenthal; Anil Vaidya; Scott L Dax
alpha-Substituted N-(sulfonamido)alkyl-beta-aminotetralins: potent and selective neuropeptide Y Y5 receptor antagonists.
Journal of medicinal chemistry 2000;43(3):346-50.
2000: James J McNally; Mark A Youngman; Timothy W Lovenberg; Diane Nepomuceno; SJ Wilson; Scott L Dax
N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor.
Bioorganic & medicinal chemistry letters 2000;10(3):213-6.
1999: Barbara Roland; Steven W Sutton; SJ Wilson; Lin Luo; J Pyati; R Huvar; Mark G Erlander; Timothy W Lovenberg
Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery.
Endocrinology 1999;140(12):5736-45.
1999: Elo Eriste; Ake Norberg; V Bonetto; Diane Nepomuceno; Timothy W Lovenberg; Rannar Sillard; Hans Jörnvall
A C-terminally elongated form of PHI from porcine intestine.
Cellular and molecular life sciences : CMLS 1999;56(7-8):709-13.
1999: A E Dubin; R Huvar; Michael R D'Andrea; J Pyati; J Y Zhu; K C Joy; SJ Wilson; Jose Galindo; C A Glass; Lin Luo; MR Jackson; Timothy W Lovenberg; Mark G Erlander
The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.
The Journal of biological chemistry 1999;274(43):30799-810.
1999: Timothy W Lovenberg; Barbara Roland; SJ Wilson; X Jiang; J Pyati; A Huvar; MR Jackson; Mark G Erlander
Cloning and functional expression of the human histamine H3 receptor.
Molecular pharmacology 1999;55(6):1101-7.
1994: Patria E Danielson; Joseph B Watson; Dan Gerendasy; Mark G Erlander; Timothy W Lovenberg; Luis de Lecea; J Gregor Sutcliffe; Wayne N Frankel
Chromosomal mapping of mouse genes expressed selectively within the central nervous system.
Genomics 1994;19(3):454-61.
1993: Timothy W Lovenberg; Mark G Erlander; B M Baron; J Gregor Sutcliffe
Cloning of new 5-HT receptors.
International clinical psychopharmacology 1993;8 Suppl 2():19-23.
1993: Timothy W Lovenberg; B M Baron; Luis de Lecea; J D Miller; R A Prosser; M A Rea; Pamela E Foye; M Racke; A L Slone; B W Siegel
A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms.
Neuron 1993;11(3):449-58.
1993: Mark G Erlander; Timothy W Lovenberg; B M Baron; Luis de Lecea; Patria E Danielson; M Racke; A L Slone; B W Siegel; Pamela E Foye; K Cannon
Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3452-6.
1993: Timothy W Lovenberg; Mark G Erlander; B M Baron; M Racke; A L Slone; B W Siegel; C M Craft; J E Burns; Patria E Danielson; J Gregor Sutcliffe
Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2184-8.
1993: Mark G Erlander; Timothy W Lovenberg; B M Baron; Luis de Lecea; J Gregor Sutcliffe
Molecular approach to hypothalamic rhythms: isolation of novel indoleamine receptor genes.
Journal of biological rhythms 1993;8 Suppl():S25-31.
1993: A Dopazo; Timothy W Lovenberg; Patria E Danielson; H P Ottiger; J Gregor Sutcliffe
Primary structure of mouse secretogranin III and its absence from deficient mice.
Journal of molecular neuroscience : MN 1993;4(4):225-33.