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Bradford Lowell

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Jong-Woo Sohn; Linh Vong; Kevin W Williams; Nina Balthasar; Eric D Berglund; Louise E Harris; Tiemin Liu; Bradford B Lowell; Joel K Elmquist
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
Shan Lou; Bradford B Lowell; Bo Duan; Linh Vong; Qiufu Ma
Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors.
Syann Lee; Bradford B Lowell; Angie L Bookout; Carol F Elias; Laurent Gautron; Matthew J Harper; Charlotte E Lee; Joel K Elmquist
Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.

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2013: Jong-Woo Sohn; Linh Vong; Kevin W Williams; Nina Balthasar; Eric D Berglund; Louise E Harris; Tiemin Liu; Bradford B Lowell; Joel K Elmquist
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
Cell 2013;152(3):612-9.
2013: Shan Lou; Bradford B Lowell; Bo Duan; Linh Vong; Qiufu Ma
Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(3):870-82.
2012: Syann Lee; Bradford B Lowell; Angie L Bookout; Carol F Elias; Laurent Gautron; Matthew J Harper; Charlotte E Lee; Joel K Elmquist
Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.
The Journal of comparative neurology 2012;520(16):3617-32.
2012: Dong Kong; Michael J Krashes; Patrick M Fuller; Shuichi Koda; David P Olson; Russell S Ray; Qingchun Tong; Linh Vong; Chianping Ye; Bradford B Lowell
GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure.
Cell 2012;151(3):645-57.
2012: Yevgenia Kozorovitskiy; Bradford B Lowell; Caroline A Johnson; Arpiar Saunders; Bernardo L Sabatini
Recurrent network activity drives striatal synaptogenesis.
Nature 2012;485(7400):646-50.
2012: Tiemin Liu; Jun B Ding; Shuichi Koda; Dong Kong; Bernardo L Sabatini; Arpiar Saunders; Bhavik P Shah; Zongfang Yang; Chianping Ye; Bradford B Lowell
Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone.
Neuron 2012;73(3):511-22.
2011: Linh Vong; Zongfang Yang; Chianping Ye; Brian Choi; Streamson Chua Jr.; Bradford B Lowell
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.
Neuron 2011;71(1):142-54.
2011: Tim Klöckener; Peter Kloppenburg; Bradford B Lowell; Lars Paeger; Jong-Woo Sohn; Linda A W Verhagen; Kevin W Williams; Jeffrey M Zigman; Harveen Dhillon; Joel K Elmquist; Brigitte Hampel; Simon Hess; Tamas L Horvath; Andreas Husch; Bengt F Belgardt; Jens C Brüning
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.
Nature neuroscience 2011;14(7):911-8.
2011: Michael J Krashes; Shuichi Koda; Chianping Ye; Sarah C Rogan; Andrew C Adams; Daniel S Cusher; Eleftheria Maratos-Flier; Bryan L Roth; Bradford B Lowell
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.
The Journal of clinical investigation 2011;121(4):1424-8.
2011: Takatoshi Mochizuki; Elda Arrigoni; Jacob N Marcus; Erika L Clark; Mihoko Yamamoto; Michael Honer; Edilio Borroni; Bradford B Lowell; Joel K Elmquist; Thomas E Scammell
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4471-6.
2011: Jari Rossi; Nina Balthasar; David P Olson; Michael Scott; Eric Berglund; Charlotte E Lee; Michelle J Choi; Danielle Lauzon; Bradford B Lowell; Joel K Elmquist
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.
Cell metabolism 2011;13(2):195-204.
2011: Martina Krenzer; Bradford B Lowell; Christelle Anaclet; Patrick M Fuller; Ramalingam Vetrivelan; Linh Vong; Nishang Wang; Jun Lu
Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia.
PloS one 2011;6(10):e24998.
2011: Michael J Higley; Aryn H Gittis; Ian A Oldenburg; Nina Balthasar; Rebecca P Seal; Robert H Edwards; Bradford B Lowell; Anatol C Kreitzer; Bernardo L Sabatini
Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
PloS one 2011;6(4):e19155.
2010: B G Irani; J Donato; David P Olson; Bradford B Lowell; T C Sacktor; M E Reyland; K P Tolson; A R Zinn; Y Ueta; I Sakata; Jeffrey M Zigman; C F Elias; D J Clegg
Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus.
Neuroscience 2010;170(4):1065-79.
2010: Yang Liu; Omar Abdel Samad; Ling Zhang; Bo Duan; Qingchun Tong; Claudia Lopes; Ru-Rong Ji; Bradford B Lowell; Qiufu Ma
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
Neuron 2010;68(3):543-56.
2010: Yong Xu; Juli E Jones; Danielle A Lauzon; Jason G Anderson; Nina Balthasar; Lora K Heisler; Andrew R Zinn; Bradford B Lowell; Joel K Elmquist
A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(44):14630-4.
2010: Dong Kong; Linh Vong; Laura E Parton; Chianping Ye; Qingchun Tong; Xiaoxia Hu; Brian Choi; Jens C Brüning; Bradford B Lowell
Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis.
Cell metabolism 2010;12(5):545-52.
2010: Yong Xu; Jennifer W Hill; Makoto Fukuda; Laurent Gautron; Jong-Woo Sohn; Ki-Woo Kim; Charlotte E Lee; Michelle J Choi; Danielle A Lauzon; Harveen Dhillon; Bradford B Lowell; Jeffrey M Zigman; Jean J Zhao; Joel K Elmquist
PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.
Cell metabolism 2010;12(1):88-95.
2010: Jennifer W Hill; Carol F Elias; Makoto Fukuda; Kevin W Williams; Eric D Berglund; William L Holland; You-Ree Cho; Jen-Chieh Chuang; Yong Xu; Michelle Choi; Danielle Lauzon; Charlotte E Lee; Roberto Coppari; James A Richardson; Jeffrey M Zigman; Streamson Chua Jr.; Philipp E Scherer; Bradford B Lowell; Jens C Brüning; Joel K Elmquist
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
Cell metabolism 2010;11(4):286-97.
2009: Zoe Hawke; Tina R Ivanov; David A Bechtold; Harveen Dhillon; Bradford B Lowell; Simon M Luckman
PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(47):14828-35.
2009: Ichiro Sakata; Yoshihide Nakano; Sherri Osborne-Lawrence; Sherry A Rovinsky; Charlotte E Lee; Mario Perello; Jason G Anderson; Roberto Coppari; Guanghua Xiao; Bradford B Lowell; Joel K Elmquist; Jeffrey M Zigman
Characterization of a novel ghrelin cell reporter mouse.
Regulatory peptides 2009;155(1-3):91-8.
2009: Anthony N van den Pol; Yang Yao; Li-Ying Fu; Kylie Foo; Hao Huang; Roberto Coppari; Bradford B Lowell; Christian Broberger
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(14):4622-39.
2008: Yong Xu; Juli E Jones; Daisuke Kohno; Kevin W Williams; Charlotte E Lee; Michelle J Choi; Jason G Anderson; Lora K Heisler; Jeffrey M Zigman; Bradford B Lowell; Joel K Elmquist
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.
Neuron 2008;60(4):582-9.
2008: Ren Zhang; Harveen Dhillon; Huali Yin; Akihiko Yoshimura; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
Endocrinology 2008;149(11):5654-61.
2008: Qingchun Tong; Chian Ping Ye; Juli E Jones; Joel K Elmquist; Bradford B Lowell
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.
Nature neuroscience 2008;11(9):998-1000.
2008: Jennifer W Hill; Kevin W Williams; Chianping Ye; Ji Luo; Nina Balthasar; Roberto Coppari; Michael Alexander cowley; Lewis C Cantley; Bradford B Lowell; Joel K Elmquist
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
The Journal of clinical investigation 2008;118(5):1796-805.
2008: Esther van de Wall; Rebecca Leshan; Allison W Xu; Nina Balthasar; Roberto Coppari; Shun Mei Liu; Young-Hwan Jo; Robert George MacKenzie; David Allison; Nae J Dun; Joel K Elmquist; Bradford B Lowell; Gregory S Barsh; Carl de Luca; Martin G Myers Jr; Gary J Schwartz; Streamson Chua Jr.
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.
Endocrinology 2008;149(4):1773-85.
2008: Nika N Danial; Loren D Walensky; Chen-Yu zhang; Cheol Soo Choi; Jill K Fisher; Anthony J A Molina; Sandeep Robert Datta; Kenneth L Pitter; Gregory H Bird; Jakob D Wikstrom; Jude T Deeney; Kirsten Robertson; Joel Morash; Ameya Kulkarni; Susanne Neschen; Sheene Kim; Michael E Greenberg; Barbara E Corkey; orian shirihai; Gerald I Shulman; Bradford B Lowell; Stanley J Korsmeyer
Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Nature medicine 2008;14(2):144-53.
2007: Laura E Parton; Chian Ping Ye; Roberto Coppari; Pablo J Enriori; Brian Choi; Chen-Yu zhang; Chun Xu; Claudia R Vianna; Nina Balthasar; Charlotte E Lee; Joel K Elmquist; Michael Alexander cowley; Bradford B Lowell
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
Nature 2007;449(7159):228-32.
2007: Michael Lazarus; Kyoko Yoshida; Roberto Coppari; Caroline E Bass; Takatoshi Mochizuki; Bradford B Lowell; Clifford B Saper
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.
Nature neuroscience 2007;10(9):1131-3.
2007: Thomas McHugh; Matthew W Jones; Jennifer J Quinn; Nina Balthasar; Roberto Coppari; Joel K Elmquist; Bradford B Lowell; Michael S Fanselow; Matthew A Wilson; Susumu Tonegawa
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.
Science (New York, N.Y.) 2007;317(5834):94-9.
2007: Qingchun Tong; Chianping Ye; Rory J McCrimmon; Harveen Dhillon; Brian Choi; Melissa D Kramer; Jia Yu; Zongfang Yang; Lauryn M Christiansen; Charlotte E Lee; Cheol Soo Choi; Jeffrey M Zigman; Gerald I Shulman; Robert S Sherwin; Joel K Elmquist; Bradford B Lowell
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
Cell metabolism 2007;5(5):383-93.
2006: Claudia R Vianna; Michael Huntgeburth; Roberto Coppari; Cheol Soo Choi; Jiandie Lin; Stefan Krauss; Giorgio Barbatelli; Iphigenia Tzameli; Young-Bum Kim; Saverio Cinti; Gerald I Shulman; Bruce M Spiegelman; Bradford B Lowell
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Cell metabolism 2006;4(6):453-64.
2006: Lora K Heisler; Erin E Jobst; Gregory M Sutton; Ligang Zhou; Erzsebet Borok; Zoe Thornton-Jones; Hong Yan Liu; Jeffrey M Zigman; Nina Balthasar; Toshiro Kishi; Charlotte E Lee; Carl J Aschkenasi; Chen-Yu zhang; Jia Yu; Olivier Boss; Kathleen G Mountjoy; Peter G Clifton; Bradford B Lowell; Jeffrey M Friedman; Tamas L Horvath; Andrew A Butler; Joel K Elmquist; Michael Alexander cowley
Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
Neuron 2006;51(2):239-49.
2006: Chen-Yu zhang; Laura E Parton; Chian Ping Ye; Stefan Krauss; Ruichao Shen; Cheng-Ting Lin; John A Porco; Bradford B Lowell
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.
Cell metabolism 2006;3(6):417-27.
2006: Harveen Dhillon; Jeffrey M Zigman; Chianping Ye; Charlotte E Lee; Robert A McGovern; Vinsee Tang; Christopher D Kenny; Lauryn M Christiansen; Ryan D White; Elisabeth A Edelstein; Roberto Coppari; Nina Balthasar; Michael Alexander cowley; Streamson Chua Jr.; Joel K Elmquist; Bradford B Lowell
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
Neuron 2006;49(2):191-203.
2005: Joel K Elmquist; Roberto Coppari; Nina Balthasar; Masumi Ichinose; Bradford B Lowell
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis.
The Journal of comparative neurology 2005;493(1):63-71.
2005: Jeffrey M Zigman; Yoshihide Nakano; Roberto Coppari; Nina Balthasar; Jacob N Marcus; Charlotte E Lee; Juli E Jones; Amy E Deysher; Amanda R Waxman; Ryan D White; Todd D Williams; Jennifer L Lachey; Randy J Seeley; Bradford B Lowell; Joel K Elmquist
Mice lacking ghrelin receptors resist the development of diet-induced obesity.
The Journal of clinical investigation 2005;115(12):3564-72.
2005: Nina Balthasar; Louise Torp Dalgaard; Charlotte E Lee; Jia Yu; Hisayuki Funahashi; Todd Williams; Manuel Ferreira; Vinsee Tang; Robert A McGovern; Christopher D Kenny; Lauryn M Christiansen; Elizabeth Edelstein; Brian Choi; Olivier Boss; Carl J Aschkenasi; Chen-Yu zhang; Kathleen G Mountjoy; Toshiro Kishi; Joel K Elmquist; Bradford B Lowell
Divergence of melanocortin pathways in the control of food intake and energy expenditure.
Cell 2005;123(3):493-505.
2005: Gemma Solanes; Neus Pedraza; Verónica Calvo; Antonio Vidal-Puig; Bradford B Lowell; Francesc Villarroya
Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region.
The Biochemical journal 2005;386(Pt 3):505-13.
2005: Stefan Krauss; Chen-Yu zhang; Bradford B Lowell
The mitochondrial uncoupling-protein homologues.
Nature reviews. Molecular cell biology 2005;6(3):248-61.
2005: Bradford B Lowell; Gerald I Shulman
Mitochondrial dysfunction and type 2 diabetes.
Science (New York, N.Y.) 2005;307(5708):384-7.
2005: Roberto Coppari; Masumi Ichinose; Charlotte E Lee; Abigail E Pullen; Christopher D Kenny; Robert A McGovern; Vinsee Tang; Shun Mei Liu; Thomas Ludwig; Streamson Chua Jr.; Bradford B Lowell; Joel K Elmquist
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.
Cell metabolism 2005;1(1):63-72.
2004: Jiandie Lin; Pei-Hsuan Wu; Paul T Tarr; Katrin S Lindenberg; Julie St-Pierre; Chen-Yu zhang; Vamsi K Mootha; Sibylle Jäger; Claudia R Vianna; Richard M Reznick; Libin Cui; Monia Manieri; Mi X Donovan; Zhidan Wu; Marcus P Cooper; Melina C Fan; Lindsay M Rohas; Ann Marie Zavacki; Saverio Cinti; Gerald I Shulman; Bradford B Lowell; Dimitri Krainc; Bruce M Spiegelman
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell 2004;119(1):121-35.
2004: Nina Balthasar; Roberto Coppari; Julie E McMinn; Shun Mei Liu; Charlotte E Lee; Vinsee Tang; Christopher D Kenny; Robert A McGovern; Streamson Chua Jr.; Joel K Elmquist; Bradford B Lowell
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.
Neuron 2004;42(6):983-91.
2003: Stefan Krauss; Chen-Yu zhang; LUCA SCORRANO; Louise Torp Dalgaard; Julie St-Pierre; Shane T Grey; Bradford B Lowell
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.
The Journal of clinical investigation 2003;112(12):1831-42.
2003: Bradford B Lowell; Eric S Bachman
Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity.
The Journal of biological chemistry 2003;278(32):29385-8.
2003: J Cliff Yoon; Gang Xu; Jude T Deeney; Shao-Nian Yang; James Rhee; Pere Puigserver; Adah R Levens; Ruojing Yang; Chen-Yu zhang; Bradford B Lowell; Per-Olof Berggren; Christopher B Newgard; Susan Bonner-Weir; Gordon Weir; Bruce M Spiegelman
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
Developmental cell 2003;5(1):73-83.
2003: Akira Nakayama; Antonio Bianco; Chen-Yu zhang; Bradford B Lowell; John V Frangioni
Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.
Molecular imaging 2003;2(1):37-49.
2002: Jeremie Boucher; Isabelle Castan-Laurell; Soazig Le Lay; D Grujic; David Sibrac; Stéphane Krief; Max Lafontan; Bradford B Lowell; Isabelle Dugail; Jean Sébastien Saulnier-Blache; Philippe Valet
Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements.
Journal of molecular endocrinology 2002;29(2):251-64.
2002: Jiandie Lin; Hai Wu; Paul T Tarr; Chen-Yu zhang; Zhidan Wu; Olivier Boss; Laura F Michael; Pere Puigserver; Eiji Isotani; Eric N Olson; Bradford B Lowell; Rhonda Bassel-Duby; Bruce M Spiegelman
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature 2002;418(6899):797-801.
2002: Eric S Bachman; Harveen Dhillon; Chen-Yu zhang; Saverio Cinti; Antonio Bianco; Brian K Kobilka; Bradford B Lowell
betaAR signaling required for diet-induced thermogenesis and obesity resistance.
Science (New York, N.Y.) 2002;297(5582):843-5.
2002: György Baffy; Chen-Yu zhang; Jonathan N Glickman; Bradford B Lowell
Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.
Hepatology (Baltimore, Md.) 2002;35(4):753-61.
2002: Stefan Krauss; Chen-Yu zhang; Bradford B Lowell
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):118-22.
2001: Laurence M Dumont; Chia-Shan Jenny Wu; Carl J Aschkenasi; Joel K Elmquist; Bradford B Lowell; Kathleen G Mountjoy
Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro.
Molecular and cellular endocrinology 2001;184(1-2):173-85.
2001: Pere Puigserver; James Rhee; Jiandie Lin; Zhidan Wu; J Cliff Yoon; Chen-Yu zhang; S Krauss; Vamsi K Mootha; Bradford B Lowell; Bruce M Spiegelman
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Molecular cell 2001;8(5):971-82.
2001: Chen-Yu zhang; György Baffy; P Perret; S Krauss; Odile D Peroni; D Grujic; T Hagen; Antonio Vidal-Puig; Olivier Boss; Y B Kim; X X Zheng; M B Wheeler; Gerald I Shulman; C B Chan; Bradford B Lowell
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Cell 2001;105(6):745-55.
2001: C Huppertz; B M Fischer; Y B Kim; K Kotani; antonio vidal-puig; Lawrence J Slieker; KW Sloop; Bradford B Lowell; B B Kahn
Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.
The Journal of biological chemistry 2001;276(16):12520-9.
2001: Cláudia R Vianna; T Hagen; Chen-Yu zhang; Eric S Bachman; Olivier Boss; Balázs Gereben; Anselmo S Moriscot; Bradford B Lowell; José Eduardo P W Bicudo; Antonio Bianco
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
Physiological genomics 2001;5(3):137-45.
2001: DS Ludwig; Nicholas A Tritos; Jason W Mastaitis; R Kulkarni; Efi Kokkotou; Joel K Elmquist; Bradford B Lowell; Jeffrey S Flier; Eleftheria Maratos-Flier
Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.
The Journal of clinical investigation 2001;107(3):379-86.
2000: Philippe Valet; D Grujic; J Wade; M Ito; Maria Cristina Zingaretti; V Soloveva; S R Ross; R A Graves; Saverio Cinti; Max Lafontan; Bradford B Lowell
Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity.
The Journal of biological chemistry 2000;275(44):34797-802.
2000: Michael Ristow; M F Pfister; Andrew J Yee; M Schubert; L Michael; Chen-Yu zhang; Kohjiro Ueki; M Dodson Michael; Bradford B Lowell; C Ronald Kahn
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12239-43.
2000: Ariel Zisman; Odile D Peroni; E Dale Abel; M Dodson Michael; Franck Mauvais-Jarvis; Bradford B Lowell; J F Wojtaszewski; Michael F Hirshman; A Virkamaki; Laurie J Goodyear; C Ronald Kahn; Barbara B Kahn
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.
Nature medicine 2000;6(8):924-8.
2000: Antonio Vidal-Puig; D Grujic; Chen-Yu zhang; T Hagen; Olivier Boss; Y Ido; A Szczepanik; J Wade; Vamsi K Mootha; Ronald N Cortright; D M Muoio; Bradford B Lowell
Energy metabolism in uncoupling protein 3 gene knockout mice.
The Journal of biological chemistry 2000;275(21):16258-66.
2000: T Hagen; Chen-Yu zhang; Cláudia R Vianna; Bradford B Lowell
Uncoupling proteins 1 and 3 are regulated differently.
Biochemistry 2000;39(19):5845-51.
2000: Olivier Boss; T Hagen; Bradford B Lowell
Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.
Diabetes 2000;49(2):143-56.
1999: Johannes Klein; Mathias Fasshauer; M Ito; Bradford B Lowell; M Benito; C Ronald Kahn
beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes.
The Journal of biological chemistry 1999;274(49):34795-802.
1999: Bradford B Lowell
PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.
Cell 1999;99(3):239-42.
1999: Olivier Boss; Eric S Bachman; Antonio Vidal-Puig; Chen-Yu zhang; Odile D Peroni; Bradford B Lowell
Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1.
Biochemical and biophysical research communications 1999;261(3):870-6.
1999: T Hagen; Chen-Yu zhang; Lawrence J Slieker; W K Chung; R L Leibel; Bradford B Lowell
Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system.
FEBS letters 1999;454(3):201-6.
1999: Zhidan Wu; Pere Puigserver; Ulf Andersson; C Zhang; G Adelmant; Vamsi K Mootha; AE Troy; Saverio Cinti; Bradford B Lowell; R C Scarpulla; Bruce M Spiegelman
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Cell 1999;98(1):115-24.
1999: Bradford B Lowell
Uncoupling protein-3 (UCP3): a mitochondrial carrier in search of a function.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23 Suppl 6():S43-5.
1999: Chen-Yu zhang; T Hagen; Vamsi K Mootha; Lawrence J Slieker; Bradford B Lowell
Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system.
FEBS letters 1999;449(2-3):129-34.
1999: Ronald N Cortright; Donghai Zheng; JP Jones; James D Fluckey; Stephen E DiCarlo; D Grujic; Bradford B Lowell; G Lynis Dohm
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation.
The American journal of physiology 1999;276(1 Pt 1):E217-21.
1998: M Shimada; Nicholas A Tritos; Bradford B Lowell; Jeffrey S Flier; Eleftheria Maratos-Flier
Mice lacking melanin-concentrating hormone are hypophagic and lean.
Nature 1998;396(6712):670-4.
1998: Daniel S Fletcher; Mari Rios Candelore; D Grujic; Bradford B Lowell; Silvi Luell; VS Susulic; D Euan MacIntyre
Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor.
The Journal of pharmacology and experimental therapeutics 1998;287(2):720-4.
1998: Bert Boyer; Brian Barnes; Bradford B Lowell; D Grujic
Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels.
The American journal of physiology 1998;275(4 Pt 2):R1232-8.
1998: M Ito; D Grujic; E Dale Abel; Antonio Vidal-Puig; VS Susulic; JA Lawitts; Mary-Ellen Harper; Jean Himms-Hagen; A D Strosberg; Bradford B Lowell
Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.
Diabetes 1998;47(9):1464-71.
1998: Bradford B Lowell
Adaptive thermogenesis: turning on the heat.
Current biology : CB 1998;8(15):R517-20.
1998: Bradford B Lowell
Using gene knockout and transgenic techniques to study the physiology and pharmacology of beta3-adrenergic receptors.
Endocrine journal 1998;45 Suppl():S9-13.
1998: Christos S Mantzoros; RC Frederich; D Qu; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations.
Diabetes 1998;47(2):230-8.
1998: J B Kim; pasha sarraf; Margaret E. Wright; K M Yao; E Mueller; Gemma Solanes; Bradford B Lowell; Bruce M Spiegelman
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
The Journal of clinical investigation 1998;101(1):1-9.
1997: Gemma Solanes; Antonio Vidal-Puig; D Grujic; Jeffrey S Flier; Bradford B Lowell
The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.
The Journal of biological chemistry 1997;272(41):25433-6.
1997: D Grujic; VS Susulic; Mary-Ellen Harper; Jean Himms-Hagen; B A Cunningham; Barbara E Corkey; Bradford B Lowell
Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice.
The Journal of biological chemistry 1997;272(28):17686-93.
1997: Antonio Vidal-Puig; Gemma Solanes; D Grujic; Jeffrey S Flier; Bradford B Lowell
UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.
Biochemical and biophysical research communications 1997;235(1):79-82.
1997: A N Hollenberg; VS Susulic; J P Madura; Bin Zhang; D E Moller; P Tontonoz; pasha sarraf; Bruce M Spiegelman; Bradford B Lowell
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
The Journal of biological chemistry 1997;272(8):5283-90.
1997: Saverio Cinti; RC Frederich; Maria Cristina Zingaretti; Rita De Matteis; Jeffrey S Flier; Bradford B Lowell
Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue.
Endocrinology 1997;138(2):797-804.
1997: Bradford B Lowell; Jeffrey S Flier
Brown adipose tissue, beta 3-adrenergic receptors, and obesity.
Annual review of medicine 1997;48():307-16.
1996: Rexford S Ahima; D Prabakaran; C Mantzoros; D Qu; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Role of leptin in the neuroendocrine response to fasting.
Nature 1996;382(6588):250-2.
1996: C S Mantzoros; D Qu; RC Frederich; VS Susulic; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.
Diabetes 1996;45(7):909-14.
1996: Antonio Vidal-Puig; M Jimenez-Liñan; Bradford B Lowell; A Hamann; E Hu; B Spiegelman; Jeffrey S Flier; D E Moller
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
The Journal of clinical investigation 1996;97(11):2553-61.
1996: A Hamann; Jeffrey S Flier; Bradford B Lowell
Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.
Endocrinology 1996;137(1):21-9.
1995: VS Susulic; RC Frederich; J Lawitts; E Tozzo; Barbara B Kahn; Mary-Ellen Harper; Jean Himms-Hagen; Jeffrey S Flier; Bradford B Lowell
Targeted disruption of the beta 3-adrenergic receptor gene.
The Journal of biological chemistry 1995;270(49):29483-92.
1995: RC Frederich; A Hamann; S Anderson; B Löllmann; Bradford B Lowell; Jeffrey S Flier
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action.
Nature medicine 1995;1(12):1311-4.
1995: Andreas Hamann; H Benecke; Y Le Marchand-Brustel; VS Susulic; Bradford B Lowell; Jeffrey S Flier
Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat.
Diabetes 1995;44(11):1266-73.
1995: RC Frederich; B Löllmann; A Hamann; A Napolitano-Rosen; Barbara B Kahn; Bradford B Lowell; Jeffrey S Flier
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.
The Journal of clinical investigation 1995;96(3):1658-63.
1994: A Napolitano; Bradford B Lowell; D Damm; R L Leibel; E Ravussin; D C Jimerson; M D Lesem; D C Van Dyke; P A Daly; P Chatis
Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1994;18(4):213-8.
1993: Bradford B Lowell; V S-Susulic; A Hamann; J A Lawitts; J Himms-Hagen; Bert Boyer; Leslie P Kozak; Jeffrey S Flier
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.
Nature 1993;366(6457):740-2.
1992: R T White; D Damm; N Hancock; B S Rosen; Bradford B Lowell; P Usher; Jeffrey S Flier; Bruce M Spiegelman
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
The Journal of biological chemistry 1992;267(13):9210-3.
1991: A Napolitano; Bradford B Lowell; Jeffrey S Flier
Alterations in sympathetic nervous system activity do not regulate adipsin gene expression in mice.
International journal of obesity 1991;15(3):227-35.
1990: Bradford B Lowell; Jeffrey S Flier
Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes.
Endocrinology 1990;127(6):2898-906.
1990: Bradford B Lowell; A Napolitano; P Usher; A G Dulloo; B S Rosen; Bruce M Spiegelman; Jeffrey S Flier
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Endocrinology 1990;126(3):1514-20.
1989: Bruce M Spiegelman; Bradford B Lowell; A Napolitano; P Dubuc; D Barton; U Francke; D L Groves; K S Cook; Jeffrey S Flier
Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
The Journal of biological chemistry 1989;264(3):1811-5.
1989: Jeffrey S Flier; Bradford B Lowell; A Napolitano; P Usher; B Rosen; K S Cook; Bruce M Spiegelman
Adipsin: regulation and dysregulation in obesity and other metabolic states.
Recent progress in hormone research 1989;45():567-80; discussion 580-1.