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Clifford Lowell

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Laura Fumagalli; Giulia Germena; Emilio Hirsch; Clifford A Lowell; Carlo C Campa; Giorgio Berton
Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.
Clare L Abram; Benjamin G Neel; Lily I Pao; Gray L Roberge; Clifford A Lowell
Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.
S Séverin; Y Zhao; Clare L Abram; Clifford A Lowell; J Mori; C A Nash; Yotis A Senis; Steve P Watson
Distinct and overlapping functional roles of Src family kinases in mouse platelets.

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2013: Laura Fumagalli; Giulia Germena; Emilio Hirsch; Clifford A Lowell; Carlo C Campa; Giorgio Berton
Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(7):3648-60.
2013: Clare L Abram; Benjamin G Neel; Lily I Pao; Gray L Roberge; Clifford A Lowell
Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.
Immunity 2013;38(3):489-501.
2012: S Séverin; Y Zhao; Clare L Abram; Clifford A Lowell; J Mori; C A Nash; Yotis A Senis; Steve P Watson
Distinct and overlapping functional roles of Src family kinases in mouse platelets.
Journal of thrombosis and haemostasis : JTH 2012;10(8):1631-45.
2012: Richard B Weiskopf; John Feiner; Jeremy Lieberman; Mark R Looney; Clifford A Lowell; David Shimabukuro; Pearl Toy; Jenifer Twiford; Michael A Gropper
Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.
Anesthesia and analgesia 2012;114(3):511-9.
2012: Pearl Toy; Richard B Weiskopf; Gregory Wilson; Jeffrey L Winters; Ping Wu; Peter Bacchetti; ognjen gajic; Manish J Gandhi; Barbara Grimes; Michael A Gropper; Nora Hirschler; Rolf Hubmayr; Monique Koenigsberg; Deanna Lee; Mark R Looney; Clifford A Lowell; David Mair; Michael A Matthay; Edward L Murphy; Philip J Norris; Rosa Sanchez Rosen; Randy Schuller
Transfusion-related acute lung injury: incidence and risk factors.
Blood 2012;119(7):1757-67.
2012: Clifford A Lowell; Tanya N Mayadas
Overview: studying integrins in vivo.
Methods in molecular biology (Clifton, N.J.) 2012;757():369-97.
2011: Jing W Zhu; Hong Zhang; Angela H Chau; Kristin Doan; Clifford A Lowell; Jason Park; Arthur Weiss
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
Immunity 2011;35(5):757-69.
2011: Emily R Elliott; Richard M Locksley; Patrizia Scapini; Brandon M Sullivan; Jessica A Van Ziffle; Clifford A Lowell
Deletion of Syk in neutrophils prevents immune complex arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4319-30.
2011: Patrizia Scapini; Qizhi Tang; Anthony L DeFranco; Yongmei Hu; Chrystelle Lamagna; Karim Lee; Clifford A Lowell
B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):E823-32.
2011: Clifford A Lowell
Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.
Cold Spring Harbor perspectives in biology 2011;3(3):.
2011: Lynn A Kamen; Joseph Schlessinger; Clifford A Lowell
Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1656-65.
2010: Rita M Tavares; Emre E Turer; Chih L Liu; Rommel Advincula; Patrizia Scapini; Lesley Rhee; Julio Barrera; Clifford A Lowell; Paul J Utz; Barbara A Malynn; Averil Ma
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
Immunity 2010;33(2):181-91.
2010: Patrizia Scapini; Yongmei Hu; Ching-Liang Chu; Thi-Sau Migone; Anthony L DeFranco; Marco A Cassatella; Clifford A Lowell
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
The Journal of experimental medicine 2010;207(8):1757-73.
2010: Anna Baruzzi; Ilaria Iacobucci; Simona Soverini; Clifford A Lowell; Giovanni Martinelli; Giorgio Berton
c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
FEBS letters 2010;584(1):15-21.
2009: Jessica Van Ziffle; Clifford A Lowell
Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
Blood 2009;114(23):4871-82.
2009: Clare L Abram; Clifford A Lowell
Leukocyte adhesion deficiency syndrome: a controversy solved.
Immunology and cell biology 2009;87(6):440-2.
2009: Cigall Kadoch; Eduard B Dinca; Ramona Voicu; Lingjing Chen; Diana Nguyen; Seema Parikh; Juliana Karrim; Marc A Shuman; Clifford A Lowell; Patrick A Treseler; C David James; James L Rubenstein
Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):1989-97.
2009: Patrizia Scapini; Shalini Pereira; Hong Zhang; Clifford A Lowell
Multiple roles of Lyn kinase in myeloid cell signaling and function.
Immunological reviews 2009;228(1):23-40.
2009: Allison L Miller; Chao Zhang; Kevan M Shokat; Clifford A Lowell
Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):988-98.
2009: Clare L Abram; Clifford A Lowell
The ins and outs of leukocyte integrin signaling.
Annual review of immunology 2009;27():339-62.
2008: Melissa R Sarantos; Hong Zhang; Ulrich Y Schaff; Neha Dixit; Heather Hayenga; Clifford A Lowell; Scott I Simon
Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8660-9.
2008: Wenbin Xiao; Hong Hong; Yuko Kawakami; Clifford A Lowell; Toshiaki Kawakami
Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.
The Journal of clinical investigation 2008;118(3):924-34.
2008: Clare L Abram; Clifford A Lowell
The diverse functions of Src family kinases in macrophages.
Frontiers in bioscience : a journal and virtual library 2008;13():4426-50.
2008: Ching-Liang Chu; Yen-Ling Yu; Kuan-Yin Shen; Clifford A Lowell; Lewis L Lanier; Jessica A Hamerman
Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
European journal of immunology 2008;38(1):166-73.
2007: Zoltan Jakus; Szabina Fodor; Clare L Abram; Clifford A Lowell; Attila Mócsai
Immunoreceptor-like signaling by beta 2 and beta 3 integrins.
Trends in cell biology 2007;17(10):493-501.
2007: Hong Hong; Jiro Kitaura; Wenbin Xiao; Vaclav Horejsi; Chisei Ra; Clifford A Lowell; Yuko Kawakami; Toshiaki Kawakami
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
Blood 2007;110(7):2511-9.
2007: Clare L Abram; Clifford A Lowell
Convergence of immunoreceptor and integrin signaling.
Immunological reviews 2007;218():29-44.
2007: Laura Fumagalli; Hong Zhang; Anna Baruzzi; Clifford A Lowell; Giorgio Berton
The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3874-85.
2007: Clare L Abram; Clifford A Lowell
The expanding role for ITAM-based signaling pathways in immune cells.
Science's STKE : signal transduction knowledge environment 2007;2007(377):re2.
2006: Xiang Xu; Dongji Zhang; Hong Zhang; Paul wolters; Nigel Killeen; Brandon M Sullivan; Richard M Locksley; Clifford A Lowell; George H Caughey
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
The Journal of experimental medicine 2006;203(13):2907-17.
2006: Attila Mócsai; Clare L Abram; Zoltan Jakus; Yongmei Hu; Lewis L Lanier; Clifford A Lowell
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
Nature immunology 2006;7(12):1326-33.
2006: Hong Zhang; Ulrich Y Schaff; Chad E Green; Hua Chen; Melissa R Sarantos; Yongmei Hu; Diane Wara; Scott I Simon; Clifford A Lowell
Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.
Immunity 2006;25(2):285-95.
2006: Cinzia Giagulli; Linda Ottoboni; Elena Caveggion; Barbara Rossi; Clifford A Lowell; Gabriela Constantin; Carlo Laudanna; Giorgio Berton
The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):604-11.
2006: Mark R Looney; Xiao Su; Jessica Van Ziffle; Clifford A Lowell; Michael A Matthay
Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
The Journal of clinical investigation 2006;116(6):1615-23.
2006: Clifford A Lowell
Rewiring phagocytic signal transduction.
Immunity 2006;24(3):243-5.
2006: Lucia De Franceschi; Emma Villa-Moruzzi; Andrea Biondani; Angela Siciliano; Carlo Brugnara; Seth L Alper; Clifford A Lowell; Giorgio Berton
Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.
Pflügers Archiv : European journal of physiology 2006;451(6):760-8.
2005: Valerie Hernandez-Hansen; Julie D J Bard; Christy A Tarleton; Julie A Wilder; Clifford A Lowell; Bridget S Wilson; Janet M Oliver
Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7880-8.
2005: Wenbin Xiao; Hajime Nishimoto; Hong Hong; Jiro Kitaura; Satoshi Nunomura; Mari Maeda-Yamamoto; Yuko Kawakami; Clifford A Lowell; Chisei Ra; Toshiaki Kawakami
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6885-92.
2005: Ching-Liang Chu; Clifford A Lowell
The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2880-9.
2005: Jessica A Hamerman; Nadia K Tchao; Clifford A Lowell; Lewis L Lanier
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
Nature immunology 2005;6(6):579-86.
2005: Jiro Kitaura; Koji Eto; Tatsuya Kinoshita; Yuko Kawakami; Michael Leitges; Clifford A Lowell; Toshiaki Kawakami
Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4495-504.
2005: Jiro Kitaura; Tatsuya Kinoshita; Masaaki Matsumoto; Shaun Chung; Yuko Kawakami; Michael Leitges; Dianqing Wu; Clifford A Lowell; Toshiaki Kawakami
IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.
Blood 2005;105(8):3222-9.
2005: Giorgio Berton; Attila Mócsai; Clifford A Lowell
Src and Syk kinases: key regulators of phagocytic cell activation.
Trends in immunology 2005;26(4):208-14.
2005: Hong Zhang; Fanying Meng; Ching-Liang Chu; Toshiyuki Takai; Clifford A Lowell
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
Immunity 2005;22(2):235-46.
2005: Silvia Continolo; Anna Baruzzi; Meytham Majeed; Elena Caveggion; Laura Fumagalli; Clifford A Lowell; Giorgio Berton
The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
Experimental cell research 2005;302(2):253-69.
2004: Shalini Pereira; Hong Zhang; Toshiyuki Takai; Clifford A Lowell
The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5757-65.
2004: Jiro Kitaura; Wenbin Xiao; Mari Maeda-Yamamoto; Yuko Kawakami; Clifford A Lowell; Toshiaki Kawakami
Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4317-23.
2004: Zoltan Jakus; Giorgio Berton; Erzsébet Ligeti; Clifford A Lowell; Attila Mócsai
Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2068-77.
2004: Clifford A Lowell
Src-family kinases: rheostats of immune cell signaling.
Molecular immunology 2004;41(6-7):631-43.
2004: Valerie Hernandez-Hansen; Alexander J Smith; Zurab Surviladze; Alexandre Chigaev; Tomas Mazel; Janet Kalesnikoff; Clifford A Lowell; Gerald Krystal; Larry A Sklar; Bridget S Wilson; Janet M Oliver
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):100-12.
2004: Attila Mócsai; Mary Beth Humphrey; Jessica Van Ziffle; Yongmei Hu; Andrew Burghardt; Steven C Spusta; Sharmila Majumdar; Lewis L Lanier; Clifford A Lowell; Mary C Nakamura
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6158-63.
2004: Patrizia Scapini; Monica Morini; Cristina Tecchio; Simona Minghelli; Emma Di Carlo; Elena Tanghetti; Adriana Albini; Clifford A Lowell; Giorgio Berton; Douglas M Noonan; Marco A Cassatella
CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):5034-40.
2004: Valerie Hernandez-Hansen; Graham A Mackay; Clifford A Lowell; Bridget S Wilson; Janet M Oliver
The Src kinase Lyn is a negative regulator of mast cell proliferation.
Journal of leukocyte biology 2004;75(1):143-51.
2003: Sally A Newbrough; Attila Mócsai; Regina A Clemens; Jennifer Nan-Wah Wu; Michael A Silverman; ANDREW SINGER; Clifford A Lowell; Gary A Koretzky
SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils.
Immunity 2003;19(5):761-9.
2003: Jiro Kitaura; Jinming Song; Mindy Tsai; Koichi Asai; Mari Maeda-Yamamoto; Attila Mócsai; Yuko Kawakami; Fu-Tong Liu; Clifford A Lowell; B George Barisas; Stephen J Galli; Toshiaki Kawakami
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12911-6.
2003: Shalini Pereira; Clifford A Lowell
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1319-27.
2003: Hua Chen; Attila Mócsai; Hong Zhang; Rong-Xian Ding; J Hiroshi Morisaki; Michael White; Jacob M Rothfork; Patrick Heiser; Emma Colucci-Guyon; Clifford A Lowell; Hattie D Gresham; Paul M Allen; Eric J Brown
Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.
Immunity 2003;19(1):95-104.
2003: Attila Mócsai; Hong Zhang; Zoltan Jakus; Jiro Kitaura; Toshiaki Kawakami; Clifford A Lowell
G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.
Blood 2003;101(10):4155-63.
2003: Elena Caveggion; Silvia Continolo; Fiona J Pixley; E Richard Stanley; David D L Bowtell; Clifford A Lowell; Giorgio Berton
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
Journal of cellular physiology 2003;195(2):276-89.
2003: Farhad Abtahian; Anastasia Guerriero; Eric Sebzda; Min Min Lu; Rong Zhou; Attila Mócsai; Erin E Myers; Bin Huang; David G Jackson; Victor A Ferrari; Victor L J Tybulewicz; Clifford A Lowell; John J Lepore; Gary A Koretzky; Mark L Kahn
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
Science (New York, N.Y.) 2003;299(5604):247-51.
2002: Lucia Vicentini; Paola Mazzi; Elena Caveggion; Silvia Continolo; Laura Fumagalli; José A Lapinet-Vera; Clifford A Lowell; Giorgio Berton
Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6446-54.
2002: Achim Obergfell; Koji Eto; Attila Mócsai; Charito S Buensuceso; Sheri L Moores; Joan S Brugge; Clifford A Lowell; Sanford J Shattil
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
The Journal of cell biology 2002;157(2):265-75.
2002: Attila Mócsai; Meijuan Zhou; Fanying Meng; Victor L J Tybulewicz; Clifford A Lowell
Syk is required for integrin signaling in neutrophils.
Immunity 2002;16(4):547-58.
2002: Susan J Stafford; Clifford A Lowell; Sanjiv Sur; Rafeul Alam
Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1978-83.
2001: Meytham Majeed; Elena Caveggion; Clifford A Lowell; Giorgio Berton
Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.
Journal of leukocyte biology 2001;70(5):801-11.
2001: Charlotte Vines; Jeffrey W Potter; Y Xu; Robert L Geahlen; P S Costello; Victor L J Tybulewicz; Clifford A Lowell; P W Chang; Hattie D Gresham; Cheryl L Willman
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
Immunity 2001;15(4):507-19.
2001: Shalini Pereira; M Zhou; Attila Mócsai; Clifford A Lowell
Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4115-23.
2001: C C Yu; T S Benedict Yen; Clifford A Lowell; Anthony L DeFranco
Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.
Current biology : CB 2001;11(1):34-8.
2000: Attila Mócsai; Zoltan Jakus; Tibor Vantus; Giorgio Berton; Clifford A Lowell; Erzsébet Ligeti
Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4321-31.
2000: S L Weinstein; A J Finn; S H Davé; Fanying Meng; Clifford A Lowell; J S Sanghera; Anthony L DeFranco
Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta.
Journal of leukocyte biology 2000;67(3):405-14.
2000: Cheryl Fitzer-Attas; M Lowry; MT Crowley; A J Finn; Fanying Meng; Anthony L DeFranco; Clifford A Lowell
Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.
The Journal of experimental medicine 2000;191(4):669-82.
2000: Hattie D Gresham; B M Dale; Jeffrey W Potter; P W Chang; Charlotte Vines; Clifford A Lowell; Carl F Lagenaur; Cheryl L Willman
Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.
The Journal of experimental medicine 2000;191(3):515-28.
1999: K A Brady; S K Atwater; Clifford A Lowell
Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates.
British journal of haematology 1999;107(4):712-5.
1999: P W Suen; Dusko Ilic; Elena Caveggion; Giorgio Berton; Caroline Damsky; Clifford A Lowell
Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
Journal of cell science 1999;112 ( Pt 22)():4067-78.
1999: Giorgio Berton; Clifford A Lowell
Integrin signalling in neutrophils and macrophages.
Cellular signalling 1999;11(9):621-35.
1999: Clifford A Lowell; G Berton
Integrin signal transduction in myeloid leukocytes.
Journal of leukocyte biology 1999;65(3):313-20.
1999: Attila Mócsai; Erzsébet Ligeti; Clifford A Lowell; Giorgio Berton
Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1120-6.
1998: Fanying Meng; Clifford A Lowell
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
The EMBO journal 1998;17(15):4391-403.
1998: Anthony L DeFranco; VW Chan; Clifford A Lowell
Positive and negative roles of the tyrosine kinase Lyn in B cell function.
Seminars in immunology 1998;10(4):299-307.
1998: Vivien Chan; Ingrid Mecklenbräuker; Irene Su; G Texido; Michael Leitges; R Carsetti; Clifford A Lowell; Klaus Rajewsky; Kensuke Miyake; Alexander Tarakhovsky
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
The Journal of experimental medicine 1998;188(1):93-101.
1998: Clifford A Lowell; G Berton
Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7580-4.
1998: VW Chan; Clifford A Lowell; Anthony L DeFranco
Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
Current biology : CB 1998;8(10):545-53.
1997: MT Crowley; P S Costello; Cheryl Fitzer-Attas; M Turner; Fanying Meng; Clifford A Lowell; Victor L J Tybulewicz; Anthony L DeFranco
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.
The Journal of experimental medicine 1997;186(7):1027-39.
1997: VW Chan; Fanying Meng; P Soriano; Anthony L DeFranco; Clifford A Lowell
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
Immunity 1997;7(1):69-81.
1997: Fanying Meng; Clifford A Lowell
Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.
The Journal of experimental medicine 1997;185(9):1661-70.
1997: Lucia De Franceschi; Laura Fumagalli; Oliviero Olivieri; Roberto Corrocher; Clifford A Lowell; Giorgio Berton
Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.
The Journal of clinical investigation 1997;99(2):220-7.
1996: Clifford A Lowell; P Soriano
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.
Genes & development 1996;10(15):1845-57.
1996: Clifford A Lowell; L Fumagalli; Giorgio Berton
Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.
The Journal of cell biology 1996;133(4):895-910.
1996: Clifford A Lowell; M Niwa; P Soriano; Harold Varmus
Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.
Blood 1996;87(5):1780-92.
1996: Giorgio Berton; S R Yan; L Fumagalli; Clifford A Lowell
Neutrophil activation by adhesion: mechanisms and pathophysiological implications.
International journal of clinical & laboratory research 1996;26(3):160-77.
1994: Clifford A Lowell; P Soriano; Harold Varmus
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
Genes & development 1994;8(4):387-98.
1994: Harold Varmus; Clifford A Lowell
Cancer genes and hematopoiesis.
Blood 1994;83(1):5-9.