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Bob Löwenberg

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Martin H van Vliet; Henk Viëtor; Jaap P L Brand; Pia Burgmer; Leonie C M de Best; Linda de Quartel; Bob Löwenberg; Peter J M Valk; Erik H van Beers
Detection of CEBPA Double Mutants in Acute Myeloid Leukemia Using a Custom Gene Expression Array.
Dimitri A Breems; Wim L J van Putten; Bob Löwenberg
The impact of abn(17p) and monosomy -5/del(5q) on the prognostic value of the monosomal karyotype in acute myeloid leukemia.
Martin H van Vliet; Henk Viëtor; Lars Bullinger; Hartmut Döhner; Konstanze Döhner; Belinda Dumee; Bob Löwenberg; Erik Simons; Peter J M Valk; Erik H van Beers
Detection of mutant NPM1 mRNA in acute myeloid leukemia using custom gene expression arrays.

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2013: Martin H van Vliet; Henk Viëtor; Jaap P L Brand; Pia Burgmer; Leonie C M de Best; Linda de Quartel; Bob Löwenberg; Peter J M Valk; Erik H van Beers
Detection of CEBPA Double Mutants in Acute Myeloid Leukemia Using a Custom Gene Expression Array.
Genetic testing and molecular biomarkers 2013;17(5):395-400.
2013: Dimitri A Breems; Wim L J van Putten; Bob Löwenberg
The impact of abn(17p) and monosomy -5/del(5q) on the prognostic value of the monosomal karyotype in acute myeloid leukemia.
Blood 2013;121(15):3056-7.
2013: Martin H van Vliet; Henk Viëtor; Lars Bullinger; Hartmut Döhner; Konstanze Döhner; Belinda Dumee; Bob Löwenberg; Erik Simons; Peter J M Valk; Erik H van Beers
Detection of mutant NPM1 mRNA in acute myeloid leukemia using custom gene expression arrays.
Genetic testing and molecular biomarkers 2013;17(4):295-300.
2013: Roland B Walter; Frederick R Appelbaum; Alan K Burnett; Anna Evans; Robert K Hills; Hagop M Kantarjian; Bob Löwenberg; Gert J Ossenkoppele; Megan Othus; Sherry R Pierce; Farhad Ravandi; Kees G M van Montfort; Elihu H Estey
Significance of FAB subclassification of "acute myeloid leukemia, NOS" in the 2008 WHO classification: analysis of 5848 newly diagnosed patients.
Blood 2013;121(13):2424-31.
2013: Eduardo M Rego; Raul C Ribeiro; Guillermo J Ruiz-Argüelles; Stanley L Schrier; Martin Tallman; Maria Soledad Undurraga; Maria del Rosario Uriarte; Nancy Berliner; Rosane Bittencourt; Maria de Lourdes L F Chauffaille; Carlos Sergio Chiattone; Evandro M Fagundes; Robert Gallagher; Arnold Ganser; Javier Garcés-Eisele; David Gómez-Almaguer; David Grimwade; Homero Gutiérrez-Aguirre; Rafael H Jacomo; Haesook T Kim; Hau C Kwaan; Francesco Lo Coco; Bob Löwenberg; Lem Martinez; Luis A Meillón; Raul A M Melo; Charlotte M Niemeyer; Katia Pagnano; Ricardo Pasquini; Miguel A Sanz
Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL.
Blood 2013;121(11):1935-43.
2013: Zejuan Li; Paul P Liu; Bob Löwenberg; Richard Morgan; Mary Beth Neilly; Haomin Ren; Janet D Rowley; Peter J M Valk; Chong-Zhi Wang; Chun-Su Yuan; Zhiyu Zhang; Ping Chen; Ruud Delwel; Konstanze Döhner; Abdel G Elkahloun; Chunjiang He; Gia-Ming Hong; Hao Huang; Xi Jiang; Rejani B Kunjamma; Yuanyuan Li; Stephen Arnovitz; Lars Bullinger; Jianjun Chen
PBX3 is an important cofactor of HOXA9 in leukemogenesis.
Blood 2013;121(8):1422-31.
2013: Bob Löwenberg
Sense and nonsense of high-dose cytarabine for acute myeloid leukemia.
Blood 2013;121(1):26-8.
2013: Bob Löwenberg; Nancy Berliner
Changing of the guard.
Blood 2013;121(1):1.
2013: Jaap Brand; Leonie de Best; Bob Löwenberg; Peter Jm Valk; Martin H van Vliet; Henk E Viëtor; Erik H van Beers
A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC.
Experimental hematology & oncology 2013;2(1):7.
2013: Stefan Gröschel; Marije Havermans; Jürgen Krauter; Michael W M Kühn; Bob Löwenberg; Michael Lübbert; Gert J Ossenkoppele; Thomas Pabst; Veronika Rockova; Brigitte Schlegelberger; Richard F Schlenk; Ingo G H Schmidt-Wolf; Gerrit J Schuurhuis; Veronica Teleanu; Peter J M Valk; Peter Vandenberghe; Edo Vellenga; Leo F Verdonck; Gregor Verhoef; Hartmut Döhner; Konstanze Döhner; Karina Eiwen; Jan Engelmann; Claudia Erpelinck; Arnold Ganser; Ulrich Germing; Mario Bargetzi; Berna Beverloo; Ruud Delwel
Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: a study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(1):95-103.
2013: Su Ming Sun; Bob Löwenberg; V Rockova; L Bullinger; M K Dijkstra; Hartmut Döhner; M Jongen-Lavrencic
The prognostic relevance of miR-212 expression with survival in cytogenetically and molecularly heterogeneous AML.
Leukemia 2013;27(1):100-6.
2012: Gert J Ossenkoppele; Thomas Pabst; Jakob R Passweg; Harry C Schouten; Georg Stussi; Arjan A van de Loosdrecht; Marinus van Marwijk Kooij; Kees van Montfort; Yvette van Norden; Edo Vellenga; Gregor Verhoef; Pierre W Wijermans; Bart J Biemond; Dimitri Breems; Georgine E De Greef; Okke de Weerdt; August Ferrant; Carlos Graux; C J M Halkes; Rene M Hollestein; Mels Hoogendoorn; Mojca Jongen-Lavrencic; Mark D Levin; Johan Maertens; Bob Löwenberg
Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK).
Blood 2012;120(24):4706-11.
2012: Cyrus Khandanpour; Joseph Krongold; Bob Löwenberg; Sara E Meyer; Chandrashekhar V Patel; Justine K Peeters; Judith Schütte; Bert A van der Reijden; Lothar Vassen; Frederique Bouwman; Fernando J Calero-Nieto; Riyan Chen; Evangelia Diamanti; Ulrich Dührsen; Marie-Claude Gaudreau; Bertie Göttgens; H Leighton Grimes; Rebecca Hannah; Joop H Jansen; Tarik Möröy
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Blood 2012;120(19):4006-17.
2012: Jan J Cornelissen; Alois Gratwohl; Gunnar Juliusson; Bob Löwenberg; Mohamad Mohty; Dietger Niederwieser; Zdenek Råcil; Jacob M Rowe; Nigel Russell; Richard F Schlenk; Jorge Sierra; Gerard Socie; Martin Bornhäuser; Gert J Ossenkoppele
The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach.
Nature reviews. Clinical oncology 2012;9(10):579-90.
2012: Frederik Damm; Ruud Delwel; Arnold Ganser; Kerstin Görlich; Michael Heuser; Bob Löwenberg; Michael Morgan; Felicitas Thol; Peter J M Valk; Katharina Wagner; Haiyang Yun; Jürgen Krauter
ID1 expression associates with other molecular markers and is not an independent prognostic factor in cytogenetically normal acute myeloid leukaemia.
British journal of haematology 2012;158(2):208-15.
2012: Ana Flávia Tibúrcio Ribeiro; Veronika Rockova; Mathijs Sanders; Peter J M Valk; Annelieke Zeilemaker; Claudia Erpelinck-Verschueren; Maria E Figueroa; Bob Löwenberg; Ari Melnick; Marta Pratcorona; Saman Abbas; Ruud Delwel
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia.
Blood 2012;119(24):5824-31.
2012: Jan J Cornelissen; Alois A Gratwohl; Berna Beverloo; Bart J Biemond; Dimitri Breems; Johan Maertens; Gert J Ossenkoppele; Thomas Pabst; Jakob R Passweg; Marinus van Marwijk Kooy; Wim L J van Putten; Edo Vellenga; Leo F Verdonck; Pierre W Wijermans; Bob Löwenberg
Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(17):2140-6.
2012: Thomas Pabst; Jakob Passweg; Harry C Schouten; Peter Sonneveld; Matthias Theobald; Wim van Putten; Marie-Christiane Vekemans; Edo Vellenga; Leo Verdonck; Mario Bargetzi; Bart Biemond; Carlos Graux; Emanuel Jacky; Marie-Cecile Legdeur; Bob Löwenberg; Johan Maertens; Gert Jan Ossenkoppele
Favorable effect of priming with granulocyte colony-stimulating factor in remission induction of acute myeloid leukemia restricted to dose escalation of cytarabine.
Blood 2012;119(23):5367-73.
2012: Rüdiger Liersch; Bob Löwenberg; Carsten Müller-Tidow; Christoph Schliemann; Christian Schwöppe; Iris Appelmann; Michael Bayer; Wolfgang E Berdel; Christoph Biermann; Thomas Büchner; Joachim Gerss; Wolfgang Hiddemann; Torsten Kessler; Rolf M Mesters
Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients.
Blood 2012;119(22):5215-20.
2012: Renée Beekman; Lianne Broeders; Wendy M Geertsma-Kleinekoort; Jurgen Haanstra; Bob Löwenberg; Mathijs A Sanders; Peter J M Valk; Marijke Valkhof; Paulette M H van Strien; Anjo J P Veerman; Roel G W Verhaak; Ivo P Touw
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia.
Blood 2012;119(22):5071-7.
2012: Elena A Federzoni; Martin F Fey; Torsten Haferlach; Bob Löwenberg; Bruce E Torbett; Peter J M Valk; Mario P Tschan
PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.
Blood 2012;119(21):4963-70.
2012: Veronika Rockova; Jolanda Luime; Emmanuel Lesaffre; Bob Löwenberg
Hierarchical Bayesian formulations for selecting variables in regression models.
Statistics in medicine 2012;31(11-12):1221-37.
2012: Marta Pratcorona; Mathijs A Sanders; Annelieke Zeilemakers; Saman Abbas; Claudia A J Erpelinck-Verschueren; François G Kavelaars; Jasper E Koenders; Bob Löwenberg; Peter J M Valk
Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value.
Haematologica 2012;97(3):388-92.
2012: Altuna Akalin; C David Allis; Debabrata Biswas; Jennifer Busuttil; Ruud Delwel; Hugo F Fernandez; Francine E Garrett-Bakelman; Jay L Hess; Yongsheng Huang; Irina Khrebtukova; Matthias Kormaksson; Bob Löwenberg; Christopher E Mason; Ari Melnick; Thomas A Milne; Elisabeth Paietta; Robert G Roeder; Gary P Schroth; Martin S Tallman; Peter J M Valk; Lu Zhang; Maria E Figueroa
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.
PLoS genetics 2012;8(6):e1002781.
2011: Bob Löwenberg; Giovanni Martinelli; Petra Muus; Gert Ossenkoppele; Sophie Rigaudeau; Philippe Rousselot; Pieter Sonneveld; Paul Stockman; Sergio Amadori; Ellin Berman; Jean-Yves Cahn; Stefan Faderl; Alison Goudie; Norbert Ifrah; Elias Jabbour; Mojca Jongen-Lavrencic; Hagop Kantarjian
Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia.
Blood 2011;118(23):6030-6.
2011: Su Ming Sun; Peter J M Valk; Bob Löwenberg; André C Bijkerk; Rik A Brooimans; Menno K Dijkstra; Stefan J Erkeland; Mojca Jongen-Lavrencic
Transition of highly specific microRNA expression patterns in association with discrete maturation stages of human granulopoiesis.
British journal of haematology 2011;155(3):395-8.
2011: Annemarie Meenhuis; Phillip A Sharp; Patrick Stern; Su Ming Sun; Erdogan Taskesen; Ivo P Touw; Arjan J van Adrichem; Nicole van Boxtel; Iris J van den Berge; Peter A van Veelen; Hans de Looper; Arnoud H de Ru; Jeroen A A Demmers; Mojca Jongen-Lavrencic; Bob Löwenberg; Stefan J Erkeland
MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice.
Blood 2011;118(4):916-25.
2011: Veronika Rockova; Wim L J van Putten; Bas J Wouters; Saman Abbas; Berna Beverloo; Ruud Delwel; Claudia Erpelinck; Bob Löwenberg; Peter J M Valk
Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers.
Blood 2011;118(4):1069-76.
2011: Frederik Damm; Ruud Delwel; Walter Fiedler; Kerstin Görlich; Anika Grosshennig; Iyas Hamwi; Gerhard Heil; Michael Heuser; Lothar Kanz; Jürgen Krauter; Bob Löwenberg; Michael Lübbert; Michael Morgan; Christoph Reuter; Ewa Surdziel; Felicitas Thol; Peter J M Valk; Katharina Wagner; Arnold Ganser
Integrative prognostic risk score in acute myeloid leukemia with normal karyotype.
Blood 2011;117(17):4561-8.
2011: Dimitri A Breems; Bob Löwenberg
Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum.
Haematologica 2011;96(4):491-3.
2011: Bob Löwenberg; Thomas Pabst; Edo Vellenga; Wim L J van Putten; Harry C Schouten; Carlos Graux; Augustin Ferrant; Pieter Sonneveld; Bart J Biemond; Alois Gratwohl; Georgine E De Greef; Leo F Verdonck; M Ronald Schaafsma; Michael Gregor; Matthias Theobald; Urs Schanz; Johan Maertens; Gert Ossenkoppele
Cytarabine dose for acute myeloid leukemia.
The New England journal of medicine 2011;364(11):1027-36.
2011: Erdogan Taskesen; Lars Bullinger; Andrea Corbacioglu; Mathijs A Sanders; Claudia Erpelinck; Bas J Wouters; Sonja C van der Poel-van de Luytgaarde; Frederik Damm; Jürgen Krauter; Arnold Ganser; Richard F Schlenk; Bob Löwenberg; Ruud Delwel; Hartmut Döhner; Peter J M Valk; Konstanze Döhner
Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity.
Blood 2011;117(8):2469-75.
2011: Alan Burnett; Meir Wetzler; Bob Löwenberg
Therapeutic advances in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(5):487-94.
2011: Sanne Lugthart; Maria E Figueroa; Eric Bindels; Lucy Skrabanek; Peter J M Valk; Yushan Li; Stefan Meyer; Claudia Erpelinck-Verschueren; John M Greally; Bob Löwenberg; Ari Melnick; Ruud Delwel
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.
Blood 2011;117(1):234-41.
2011: Renée Beekman; Stefan J Erkeland; Bob Löwenberg; Justine K Peeters; Veronika Rockova; Erdogan Taskesen; Peter J M Valk; Marijke Valkhof; Ivo P Touw
Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator.
PloS one 2011;6(10):e26537.
2010: Maria E Figueroa; Omar Abdel-Wahab; Chao Lu; Patrick S Ward; Jay Patel; Alan Shih; Yushan Li; Neha Bhagwat; Aparna Vasanthakumar; Hugo F Fernandez; Martin S Tallman; Zhuoxin Sun; Kristy Wolniak; Justine K Peeters; Wei Liu; Sung E Choe; Valeria R Fantin; Elisabeth Paietta; Bob Löwenberg; Jonathan D Licht; Lucy A Godley; Ruud Delwel; Peter J M Valk; Craig Thompson; Ross L Levine; Ari Melnick
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Cancer cell 2010;18(6):553-67.
2010: Marieke Bruinsma; Evert-Jan Wils; Bob Löwenberg; Jan J Cornelissen; Eric Braakman
The impact of CD4+Foxp3+ Treg on immunity to murine cytomegalovirus after bone marrow transplantation depends on the peripheral or thymic source of T cell regeneration.
Transplant immunology 2010;24(1):9-16.
2010: Bob Löwenberg; Gareth Morgan; Gert Ossenkoppele; Alan K Burnett; Pierre Zachée; Ulrich Dührsen; Daan Dierickx; Carsten Müller-Tidow; Pieter Sonneveld; Utz Krug; Elisabeth Bone; Nicolas Flores; Alison F Richardson; Leon Hooftman; Chris Jenkins; Sonja Zweegman; Faith Davies
Phase I/II clinical study of Tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(28):4333-8.
2010: Saman Abbas; Sanne Lugthart; François G Kavelaars; Anita Schelen; Jasper E Koenders; Annelieke Zeilemaker; Wim J L van Putten; Anita W Rijneveld; Bob Löwenberg; Peter J M Valk
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.
Blood 2010;116(12):2122-6.
2010: Hendrik J M de Jonge; Peter J M Valk; Nic J G M Veeger; Arja ter Elst; Monique L den Boer; Jacqueline Cloos; Valérie de Haas; Marry M van den Heuvel-Eibrink; G J L Kaspers; Christian M Zwaan; Willem A Kamps; Bob Löwenberg; Eveline S J M de Bont
High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.
Blood 2010;116(10):1747-54.
2010: Sanne Lugthart; Stefan Gröschel; Berna Beverloo; Sabine Kayser; Peter J M Valk; Shama Lydia van Zelderen-Bhola; Gert Jan Ossenkoppele; Edo Vellenga; Eva van den Berg-de Ruiter; Urs Schanz; Gregor Verhoef; Peter Vandenberghe; Augustin Ferrant; Claus-Henning Köhne; Michael Pfreundschuh; Heinz A Horst; Elisabeth Koller; Marie von Lilienfeld-Toal; Martin Bentz; Arnold Ganser; Brigitte Schlegelberger; Martine Jotterand; Jürgen Krauter; Thomas Pabst; Matthias Theobald; Richard F Schlenk; Ruud Delwel; Konstanze Döhner; Bob Löwenberg; Hartmut Döhner
Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(24):3890-8.
2010: Pau Montesinos; José D González; José González; Chelo Rayón; Elena de Lisa; Maria L Amigo; Gert Ossenkoppele; María J Peñarrubia; Manuel Pérez-Encinas; Juan Bergua; Guillermo Deben; María J Sayas; Javier de la Serna; Josep M Ribera; Javier Bueno; Gustavo Milone; Concepción Rivas; Salut Brunet; Bob Löwenberg; Miguel Sanz
Therapy-related myeloid neoplasms in patients with acute promyelocytic leukemia treated with all-trans-retinoic Acid and anthracycline-based chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(24):3872-9.
2010: Wendy Deenik; J J W M Janssen; Bronno van der Holt; Gregor Verhoef; Willem M Smit; Marie José Kersten; Simon M G J Daenen; Leo F Verdonck; Augustin Ferrant; A V M B Schattenberg; Pieter Sonneveld; Marinus van Marwijk Kooy; Shulamiet Wittebol; Roelof Willemze; Pierre W Wijermans; Berna Beverloo; Bob Löwenberg; Peter J M Valk; Gert Ossenkoppele; Jan J Cornelissen
Efficacy of escalated imatinib combined with cytarabine in newly diagnosed patients with chronic myeloid leukemia.
Haematologica 2010;95(6):914-21.
2010: Stefan Gröschel; Sanne Lugthart; Richard F Schlenk; Peter J M Valk; Karina Eiwen; Chantal Goudswaard; Wim J L van Putten; Sabine Kayser; Leo F Verdonck; Michael Lübbert; Gert-Jan Ossenkoppele; Ulrich Germing; Ingo Schmidt-Wolf; Brigitte Schlegelberger; Jürgen Krauter; Arnold Ganser; Hartmut Döhner; Bob Löwenberg; Konstanze Döhner; Ruud Delwel
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(12):2101-7.
2010: Bob Löwenberg; Joachim Beck; Carlos Graux; Wim van Putten; Harry C Schouten; Leo F Verdonck; Augustin Ferrant; Pieter Sonneveld; Mojca Jongen-Lavrencic; Marie von Lilienfeld-Toal; Bart J Biemond; Edo Vellenga; Dimitri Breems; Hilde de Muijnck; Ron Schaafsma; Gregor Verhoef; Hartmut Döhner; Alois Gratwohl; Thomas Pabst; Gert Ossenkoppele; Johan Maertens
Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study.
Blood 2010;115(13):2586-91.
2010: S Abbas; Claudia A J Erpelinck-Verschueren; Chantal S Goudswaard; Bob Löwenberg; Peter J M Valk
Mutant Wilms' tumor 1 (WT1) mRNA with premature termination codons in acute myeloid leukemia (AML) is sensitive to nonsense-mediated RNA decay (NMD).
Leukemia 2010;24(3):660-3.
2010: Hartmut Döhner; Elihu H Estey; Sergio Amadori; Frederick R Appelbaum; Thomas Büchner; Alan K Burnett; Hervé Dombret; Pierre Fenaux; David Grimwade; Richard A Larson; Francesco Lo Coco; Tomoki Naoe; Dietger Niederwieser; Gert Ossenkoppele; MA Sanz; Jorge Sierra; Martin S Tallman; Bob Löwenberg; Clara D Bloomfield
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.
Blood 2010;115(3):453-74.
2010: Maria E Figueroa; Sanne Lugthart; Yushan Li; Claudia Erpelinck-Verschueren; Xutao Deng; Paul J Christos; Elizabeth Schifano; James Booth; Wim van Putten; Lucy Skrabanek; Fabien Campagne; Madhu Mazumdar; John M Greally; Peter J M Valk; Bob Löwenberg; Ruud Delwel; Ari Melnick
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.
Cancer cell 2010;17(1):13-27.
2009: Arati V Rao; Peter J M Valk; Klaus Metzeler; Chaitanya R Acharya; Sascha A Tuchman; Marvaretta M Stevenson; David A Rizzieri; Ruud Delwel; Christian Buske; Stefan K Bohlander; Anil Potti; Bob Löwenberg
Age-specific differences in oncogenic pathway dysregulation and anthracycline sensitivity in patients with acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(33):5580-6.
2009: Michael Heuser; Laura M Sly; Bob Argiropoulos; Florian Kuchenbauer; Courteney Lai; Andrew Weng; Malina Leung; Grace Lin; Christy Brookes; Stephen Fung; Peter J Valk; Ruud Delwel; Bob Löwenberg; Gerald Krystal; R Keith Humphries
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.
Blood 2009;114(19):3983-93.
2009: Miguel Sanz; Alan Burnett; Francesco Lo Coco; Bob Löwenberg
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
Current opinion in oncology 2009;21(6):594-600.
2009: Hendrik J M de Jonge; Eveline S J M de Bont; Peter J M Valk; Jan Jacob Schuringa; Marcel Kies; Carolien M Woolthuis; Ruud Delwel; Nic J G M Veeger; Edo Vellenga; Bob Löwenberg; Gerwin Huls
AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.
Blood 2009;114(14):2869-77.
2009: Bob Löwenberg; Gert Ossenkoppele; Wim L J van Putten; Harry C Schouten; Carlos Graux; Augustin Ferrant; Pieter Sonneveld; Johan Maertens; Mojca Jongen-Lavrencic; Marie von Lilienfeld-Toal; Bart J Biemond; Edo Vellenga; Marinus van Marwijk Kooy; Leo F Verdonck; Joachim Beck; Hartmut Döhner; Alois Gratwohl; Thomas Pabst; Gregor Verhoef
High-dose daunorubicin in older patients with acute myeloid leukemia.
The New England journal of medicine 2009;361(13):1235-48.
2009: Marieke Bruinsma; Peter L van Soest; Pieter J M Leenen; Bob Löwenberg; Jan J Cornelissen; Eric Braakman
Keratinocyte growth factor improves allogeneic bone marrow engraftment through a CD4+Foxp3+ regulatory T cell-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7364-9.
2009: Bas J Wouters; Bob Löwenberg; Claudia A J Erpelinck-Verschueren; Wim L J van Putten; Peter J M Valk; Ruud Delwel
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.
Blood 2009;113(13):3088-91.
2009: Maria E Figueroa; Bas J Wouters; Lucy Skrabanek; Jacob Glass; Yushan Li; Claudia A J Erpelinck-Verschueren; Anton W Langerak; Bob Löwenberg; Melissa Fazzari; John M Greally; Peter J M Valk; Ari Melnick; Ruud Delwel
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.
Blood 2009;113(12):2795-804.
2009: Jan J Cornelissen; Bronno van der Holt; Gregor Verhoef; Mars B van't Veer; Marinus H J van Oers; Harry C Schouten; Gert Ossenkoppele; Pieter Sonneveld; Johan Maertens; Marinus van Marwijk Kooy; M Ronald Schaafsma; Pierre W Wijermans; Douwe H Biesma; Shulamiet Wittebol; Paul J Voogt; Joke W Baars; Pierre Zachée; Leo F Verdonck; Bob Löwenberg; Adriaan W Dekker
Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison.
Blood 2009;113(6):1375-82.
2009: Bas J Wouters; Bob Löwenberg; Ruud Delwel
A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.
Blood 2009;113(2):291-8.
2009: R A Brooimans; Jan J Cornelissen; Jaco Kraan; Bob Löwenberg; W van Putten; Jan W Gratama
Flow cytometric differential of leukocyte populations in normal bone marrow: influence of peripheral blood contamination.
Cytometry. Part B, Clinical cytometry 2009;76(1):18-26.
2009: Roel G W Verhaak; Bas J Wouters; Claudia A J Erpelinck; Saman Abbas; Berna Beverloo; Sanne Lugthart; Bob Löwenberg; Ruud Delwel; Peter J M Valk
Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling.
Haematologica 2009;94(1):131-4.
2008: M E D Chamuleau; Arjan A van de Loosdrecht; Corine J Hess; J J W M Janssen; Adri Zevenbergen; Ruud Delwel; Peter J M Valk; Bob Löwenberg; Gert Ossenkoppele
High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.
Haematologica 2008;93(12):1894-8.
2008: Dimitri A Breems; Wim L J van Putten; Georgine E De Greef; Shama L van Zelderen-Bhola; Klasien B J Gerssen-Schoorl; Clemens H M Mellink; Aggie Nieuwint; Martine Jotterand; Anne Hagemeijer; Berna Beverloo; Bob Löwenberg
Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(29):4791-7.
2008: Saman Abbas; Gabriëlle Rotmans; Bob Löwenberg; Peter J M Valk
Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias.
Haematologica 2008;93(10):1595-7.
2008: Arcangelo Liso; Filippo Castiglione; Antonio Cappuccio; Fabrizio Stracci; Richard F Schlenk; Sergio Amadori; Christian Thiede; Susanne Schnittger; Peter J M Valk; Konstanze Döhner; Massimo F Martelli; Markus Schaich; Jürgen Krauter; Arnold Ganser; Maria P Martelli; Niccolò Bolli; Bob Löwenberg; Torsten Haferlach; Gerhard Ehninger; Franco Mandelli; Hartmut Döhner; Franziska Michor; Brunangelo Falini
A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).
Haematologica 2008;93(8):1219-26.
2008: Jan W Gratama; Rik A Brooimans; Bronno van der Holt; Kees Sintnicolaas; Gerard van Doornum; Hubertus G Niesters; Bob Löwenberg; Jan J Cornelissen
Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations.
Cytometry. Part B, Clinical cytometry 2008;74(4):211-20.
2008: Mojca Jongen-Lavrencic; Su Ming Sun; Menno K Dijkstra; Peter J M Valk; Bob Löwenberg
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia.
Blood 2008;111(10):5078-85.
2008: Bob Löwenberg
Diagnosis and prognosis in acute myeloid leukemia--the art of distinction.
The New England journal of medicine 2008;358(18):1960-2.
2008: Bart J A Rijnders; Jan J Cornelissen; Lennert Slobbe; Martin J Becker; Jeanette K Doorduijn; Wim C J Hop; Elisabeth J Ruijgrok; Bob Löwenberg; Arnold Vulto; Pieternella J Lugtenburg; Siem de Marie
Aerosolized liposomal amphotericin B for the prevention of invasive pulmonary aspergillosis during prolonged neutropenia: a randomized, placebo-controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1401-8.
2008: Sanne Lugthart; Ellen van Drunen; Yvette van Norden; Antoinette van Hoven; Claudia Erpelinck; Peter J M Valk; Berna Beverloo; Bob Löwenberg; Ruud Delwel
High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.
Blood 2008;111(8):4329-37.
2008: Wendy Deenik; Bronno van der Holt; Gregor Verhoef; Willem M Smit; Marie J Kersten; Hanneke C Kluin-Nelemans; Leo F Verdonck; Augustin Ferrant; A V M B Schattenberg; Jeroen J W M Janssen; Pieter Sonneveld; Marinus van Marwijk Kooy; Shulamiet Wittebol; Roelof Willemze; Pierre W Wijermans; Petra H M Westveer; Berna Beverloo; Peter Valk; Bob Löwenberg; Gert Ossenkoppele; Jan J Cornelissen
Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia.
Blood 2008;111(5):2581-8.
2008: mitch raponi; Jeffrey E Lancet; Hongtao Fan; Lesley Dossey; Grace Lee; Ivana Gojo; Eric J Feldman; Jason Gotlib; Lawrence E Morris; Peter L Greenberg; John J Wright; Jean-Luc Harousseau; Bob Löwenberg; Richard M Stone; Peter De Porre; Yixin Wang; Judith E Karp
A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia.
Blood 2008;111(5):2589-96.
2008: sake wageningen; Marleen C Breems-de Ridder; Jeannet Nigten; Gorica Nikoloski; Claudia A J Erpelinck-Verschueren; Bob Löwenberg; Theo de Witte; Daniel G Tenen; Bert A van der Reijden; Joop H Jansen
Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha.
Blood 2008;111(3):1634-43.
2008: Mathijs A Sanders; Roel G W Verhaak; Wendy M C Geertsma-Kleinekoort; Saman Abbas; Sebastiaan Horsman; Peter van der Spek; Bob Löwenberg; Peter J M Valk
SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels.
BMC genomics 2008;9():41.
2007: Marieke Bruinsma; Peter L van Soest; Pieter J M Leenen; Bart N Lambrecht; Tom Cupedo; Bob Löwenberg; Jan J Cornelissen; Eric Braakman
Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7424-30.
2007: Bas J Wouters; Meritxell Alberich Jordà; Karen Keeshan; Irene Louwers; Claudia A J Erpelinck-Verschueren; Dennis Tielemans; Anton Langerak; Yiping He; Yumi Yashiro-ohtani; Pu Zhang; Christopher J Hetherington; Roel G W Verhaak; Peter J M Valk; Bob Löwenberg; Daniel G Tenen; Warren S Pear; Ruud Delwel
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Blood 2007;110(10):3706-14.
2007: Bas J Wouters; Mathijs A Sanders; S Lugthart; W M C Geertsma-Kleinekoort; Ellen van Drunen; Berna Beverloo; Bob Löwenberg; Peter J M Valk; Ruud Delwel
Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia.
Leukemia 2007;21(11):2382-4.
2007: Dimitri A Breems; Bob Löwenberg
Acute myeloid leukemia and the position of autologous stem cell transplantation.
Seminars in hematology 2007;44(4):259-66.
2007: Annoek E C Broers; Marieke Bruinsma; Sandra J Posthumus-van Sluijs; Evert-Jan Wils; Hergen Spits; Bob Löwenberg; Eric Braakman; Jan J Cornelissen
IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells.
Haematologica 2007;92(8):1099-106.
2007: Nazik Rayman; King H Lam; Joost Van Leeuwen; Andries H Mulder; Leo M Budel; Bob Löwenberg; Pieter Sonneveld; Ruud Delwel
The expression of the peripheral cannabinoid receptor on cells of the immune system and non-Hodgkin's lymphomas.
Leukemia & lymphoma 2007;48(7):1389-99.
2007: Reinier M van Hest; Jeanette K Doorduijn; Brenda de Winter; Jan J Cornelissen; Arnold G Vulto; Michael Oellerich; Bob Löwenberg; Ron A A Mathot; Victor W Armstrong; Teun van Gelder
Pharmacokinetics of mycophenolate mofetil in hematopoietic stem cell transplant recipients.
Therapeutic drug monitoring 2007;29(3):353-60.
2007: Walbert J Bakker; Thamar B van Dijk; Martine Parren-van Amelsvoort; Andrea Kolbus; Kazuo Yamamoto; Peter Steinlein; Roel G W Verhaak; Tak W Mak; Hartmut Beug; Bob Löwenberg; Marieke von Lindern
Differential regulation of Foxo3a target genes in erythropoiesis.
Molecular and cellular biology 2007;27(10):3839-3854.
2007: Marry M van den Heuvel-Eibrink; Bronno van der Holt; Alan K Burnett; Wolfgang Knauf; Martin F Fey; Gregor Verhoef; Edo Vellenga; Gert Ossenkoppele; Bob Löwenberg; Pieter Sonneveld
CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age.
Annals of hematology 2007;86(5):329-37.
2007: mitch raponi; Jean-Luc Harousseau; Jeffrey E Lancet; Bob Löwenberg; Richard Stone; Yi Zhang; Wayne Rackoff; Yixin Wang; David Atkins
Identification of molecular predictors of response in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2254-60.
2007: Mark Schellings; Bob Löwenberg; Yigal M Pinto
Another look at imatinib mesylate.
The New England journal of medicine 2007;356(11):1183; author reply 1183.
2007: Evert-Jan Wils; Eric Braakman; Georges M G M Verjans; Elwin J C Rombouts; Annoek E C Broers; Hubert G M Niesters; Gerard Wagemaker; Frank Staal; Bob Löwenberg; Hergen Spits; Jan J Cornelissen
Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3551-7.
2007: Jean-Pierre Armand; Alan K Burnett; Johannes Drach; Jean-Luc Harousseau; Bob Löwenberg; Jesús San Miguel
The emerging role of targeted therapy for hematologic malignancies: update on bortezomib and tipifarnib.
The oncologist 2007;12(3):281-90.
2007: W Deenik; Bronno van der Holt; Gregor Verhoef; A V M B Schattenberg; Leo F Verdonck; S M G J Daenen; Pierre Zachée; Petra H M Westveer; W M Smit; Shulamiet Wittebol; Harry C Schouten; Bob Löwenberg; Gert Ossenkoppele; Jan J Cornelissen
High-vs low-dose cytarabine combined with interferon alfa in patients with first chronic phase chronic myeloid leukemia. A prospective randomized phase III study.
Annals of hematology 2007;86(2):117-25.
2007: Bas J Wouters; Irene Louwers; Peter J M Valk; Bob Löwenberg; Ruud Delwel
A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML.
Blood 2007;109(1):389-90.
2007: Bob Löwenberg
On the road to new drugs in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(1):1-2.
2007: Bronno van der Holt; Dimitri A Breems; H Berna Beverloo; Eva van den Berg; Alan K Burnett; Pieter Sonneveld; Bob Löwenberg
Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a prospective clinical trial.
British journal of haematology 2007;136(1):96-105.
2006: Bronno van der Holt; Marry M van den Heuvel-Eibrink; Ron van Schaik; Ilse P van der Heiden; Erik A C Wiemer; P J M Vossebeld; Bob Löwenberg; Pieter Sonneveld
ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients.
Clinical pharmacology and therapeutics 2006;80(5):427-39.
2006: P A W te Boekhorst; Cor H J Lamers; MR Schipperus; Rogier Q Hintzen; Bronno van der Holt; Jan J Cornelissen; Bob Löwenberg; Jan W Gratama
T-lymphocyte reconstitution following rigorously T-cell-depleted versus unmodified autologous stem cell transplants.
Bone marrow transplantation 2006;37(8):763-72.
2006: Margreet C Vos; Hubert P Endtz; Deborah Horst-Kreft; Jeanette K Doorduijn; Elly Lugtenburg; Henri A Verbrugh; Bob Löwenberg; Siem de Marie; Cindy van Pelt; Alex Van Belkum
Candida krusei transmission among hematology patients resolved by adapted antifungal prophylaxis and infection control measures.
Journal of clinical microbiology 2006;44(3):1111-4.
2006: Stefan J Erkeland; Roel G W Verhaak; Peter J M Valk; Ruud Delwel; Bob Löwenberg; Ivo P Touw
Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia.
Cancer research 2006;66(2):622-6.
2006: Roel G W Verhaak; Mathijs A Sanders; Maarten A Bijl; Ruud Delwel; Sebastiaan Horsman; Michael J Moorhouse; Peter van der Spek; Bob Löwenberg; Peter J M Valk
HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics.
BMC bioinformatics 2006;7():337.
2006: J P A Samijn; P A W te Boekhorst; Tjeerd Mondria; Pieter A Van Doorn; H Zwenneke Flach; F G A Van der Meché; J Cornelissen; Wim C J Hop; Bob Löwenberg; Rogier Q Hintzen
Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2006;77(1):46-50.
2005: Jurgen A F Marteijn; Liesbeth van Emst; Claudia A J Erpelinck-Verschueren; Gorica Nikoloski; Aswin L Menke; Theo de Witte; Bob Löwenberg; Joop H Jansen; Bert A van der Reijden
The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.
Blood 2005;106(13):4114-23.
2005: Roel G W Verhaak; Chantal S Goudswaard; Wim L J van Putten; Maarten A Bijl; Mathijs A Sanders; Wendy Hugens; André G Uitterlinden; Claudia Erpelinck; Ruud Delwel; Bob Löwenberg; Peter J M Valk
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance.
Blood 2005;106(12):3747-54.
2005: Bronno van der Holt; Bob Löwenberg; Alan K Burnett; Wolfgang Knauf; John Shepherd; Pier Paolo Piccaluga; Gert Ossenkoppele; Gregor Verhoef; Augustin Ferrant; Michael Crump; Dominik Selleslag; Matthias Theobald; Martin F Fey; Edo Vellenga; Margaret Dugan; Pieter Sonneveld
The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis.
Blood 2005;106(8):2646-54.
2005: Richard A Larson; Eric L Sievers; Edward A Stadtmauer; Bob Löwenberg; Elihu H Estey; Hervé Dombret; Matthias Theobald; Dimitris Voliotis; John M Bennett; Maria Richie; Lance H Leopold; Mark S Berger; Matthew L Sherman; Michael R Loken; Jacques J M van Dongen; Irwin D Bernstein; Frederick R Appelbaum
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence.
Cancer 2005;104(7):1442-52.
2005: Dimitri A Breems; Bob Löwenberg
Autologous stem cell transplantation in the treatment of adults with acute myeloid leukaemia.
British journal of haematology 2005;130(6):825-33.
2005: Mies C Kappers-Klunne; Pierre W Wijermans; Rob Fijnheer; Alexandra J Croockewit; Bronno van der Holt; J T M de Wolf; Bob Löwenberg; A Brand
Splenectomy for the treatment of thrombotic thrombocytopenic purpura.
British journal of haematology 2005;130(5):768-76.
2005: Annoek E C Broers; Bronno van der Holt; Sebastiaan Haze; Eric Braakman; Jan W Gratama; Bob Löwenberg; Jan J Cornelissen
A comparison of postengraftment infectious morbidity and mortality after allogeneic partially T cell-depleted peripheral blood progenitor cell transplantation versus T cell-depleted bone marrow transplantation.
Experimental hematology 2005;33(8):912-9.
2005: Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Dominik Spensberger; Yvonne de Knegt; Michelle Tang; Bob Löwenberg; Ruud Delwel
Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.
Oncogene 2005;24(25):4129-37.
2005: Eric van den Akker; Yolanda Vankan-Berkhoudt; Peter J M Valk; Bob Löwenberg; Ruud Delwel
The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia.
Journal of virology 2005;79(9):5249-58.
2005: J Nigten; M C Breems-de Ridder; Claudia A J Erpelinck-Verschueren; G Nikoloski; Bert A van der Reijden; sake wageningen; P B van Hennik; Theo de Witte; Bob Löwenberg; Joop H Jansen
ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells.
Leukemia 2005;19(5):799-805.
2005: Dimitri A Breems; Wim L J van Putten; Peter C Huijgens; Gert Ossenkoppele; Gregor Verhoef; Leo F Verdonck; Edo Vellenga; Georgine E De Greef; Emanuel Jacky; Johannes Van Der Lelie; Marc Boogaerts; Bob Löwenberg
Prognostic index for adult patients with acute myeloid leukemia in first relapse.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(9):1969-78.
2005: Jan J Cornelissen; Bob Löwenberg
Role of allogeneic stem cell transplantation in current treatment of acute myeloid leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005;():151-5.
2005: Georgine E De Greef; Wim L J van Putten; Marc Boogaerts; Peter C Huijgens; Leo F Verdonck; Edo Vellenga; Matthias Theobald; Emanuel Jacky; Bob Löwenberg
Criteria for defining a complete remission in acute myeloid leukaemia revisited. An analysis of patients treated in HOVON-SAKK co-operative group studies.
British journal of haematology 2005;128(2):184-91.
2005: Dimitri A Breems; Marc Boogaerts; Adriaan W Dekker; Wim L J van Putten; Pieter Sonneveld; Peter C Huijgens; Johannes Van Der Lelie; Edo Vellenga; Alois Gratwohl; Gregor Verhoef; Leo F Verdonck; Bob Löwenberg
Autologous bone marrow transplantation as consolidation therapy in the treatment of adult patients under 60 years with acute myeloid leukaemia in first complete remission: a prospective randomized Dutch-Belgian Haemato-Oncology Co-operative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK) trial.
British journal of haematology 2005;128(1):59-65.
2005: Peter J M Valk; Ruud Delwel; Bob Löwenberg
Gene expression profiling in acute myeloid leukemia.
Current opinion in hematology 2005;12(1):76-81.
2004: S M G J Daenen; Bronno van der Holt; Gregor Verhoef; Bob Löwenberg; Pierre W Wijermans; Peter C Huijgens; Rien van Marwijk Kooy; Harry C Schouten; Mark H H Kramer; Augustin Ferrant; Eva van den Berg; Monique M C Steijaert; Leo F Verdonck; Pieter Sonneveld
Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia: a randomised phase II trial from HOVON, the Dutch-Belgian Haemato-Oncology Working Group for adults.
Leukemia research 2004;28(10):1057-67.
2004: Marieke Joosten; Montserrat Blázquez-Domingo; Fokke Lindeboom; Florence Boulmé; Antoinette Van Hoven-Beijen; Bianca Habermann; Bob Löwenberg; Hartmut Beug; Ernst W Müllner; Ruud Delwel; Marieke von Lindern
Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling.
The Journal of biological chemistry 2004;279(37):38169-76.
2004: Elwin J C Rombouts; Biljana Pavic; Bob Löwenberg; Rob E Ploemacher
Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia.
Blood 2004;104(2):550-7.
2004: Meritxell Alberich Jordà; Nazik Rayman; Marjolein Tas; Sandra E Verbakel; Natalia Battista; Kirsten van Lom; Bob Löwenberg; Mauro Maccarrone; Ruud Delwel
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner.
Blood 2004;104(2):526-34.
2004: emile van den akker; Thamar B van Dijk; Martine Parren-van Amelsvoort; Katja S Grossmann; Ute Schaeper; Kenya Toney-Earley; Susan E Waltz; Bob Löwenberg; Marieke von Lindern
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.
Blood 2004;103(12):4457-65.
2004: Karin A Mattern; Susan J J Swiggers; Alex L Nigg; Bob Löwenberg; Adriaan B Houtsmuller; J Mark J M Zijlmans
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.
Molecular and cellular biology 2004;24(12):5587-94.
2004: emile van den akker; Thamar B van Dijk; Uwe Schmidt; Lamberto Felida; Hartmut Beug; Bob Löwenberg; Marieke von Lindern
The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity.
Biological chemistry 2004;385(5):409-13.
2004: Peter J M Valk; Roel G W Verhaak; M Antoinette Beijen; Claudia Erpelinck; Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Judith M Boer; Berna Beverloo; Michael J Moorhouse; Peter van der Spek; Bob Löwenberg; Ruud Delwel
Prognostically useful gene-expression profiles in acute myeloid leukemia.
The New England journal of medicine 2004;350(16):1617-28.
2004: Gert Ossenkoppele; Wilfried J Graveland; Pieter Sonneveld; S M G J Daenen; Douwe H Biesma; Leo F Verdonck; M Ronald Schaafsma; Petra H M Westveer; Godefridus J Peters; Paul Noordhuis; Petra Muus; Dominik Selleslag; Bronno van der Holt; Michel Delforge; Bob Löwenberg; Gregor Verhoef
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
Blood 2004;103(8):2908-13.
2004: Uwe Schmidt; emile van den akker; Martine Parren-van Amelsvoort; Gabi Litos; Marella de Bruijn; Laura Gutiérrez; Rudolf W Hendriks; Wilfried Ellmeier; Bob Löwenberg; Hartmut Beug; Marieke von Lindern
Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.
The Journal of experimental medicine 2004;199(6):785-95.
2004: Martijn T Groot; Michel van Agthoven; Bob Löwenberg; R Willemze; Carin A Uyl-de Groot
[The role of cost analysis in the evaluation of the development of medical technology. The case of allogenic stem-cell transplantation].
Nederlands tijdschrift voor geneeskunde 2004;148(10):480-4.
2004: Nazik Rayman; King H Lam; Jon D Laman; Peter J Simons; Bob Löwenberg; Pieter Sonneveld; Ruud Delwel
Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2111-7.
2004: Walbert J Bakker; Montserrat Blázquez-Domingo; Andrea Kolbus; Janey Besooyen; Peter Steinlein; Hartmut Beug; Paul J Coffer; Bob Löwenberg; Marieke von Lindern; Thamar B van Dijk
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.
The Journal of cell biology 2004;164(2):175-84.
2004: Peter J M Valk; David T Bowen; Marion E Frew; Anne C Goodeve; Bob Löwenberg; John T Reilly
Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16).
Haematologica 2004;89(1):106.
2004: Mark-David Levin; Mies C Kappers-Klunne; Kees Sintnicolaas; Bronno van der Holt; Huub H D M van Vliet; Bob Löwenberg; Mars B van't Veer
The value of alloantibody detection in predicting response to HLA-matched platelet transfusions.
British journal of haematology 2004;124(2):244-50.
2003: Bruce D Cheson; John M Bennett; Kenneth J Kopecky; Thomas Büchner; Cheryl L Willman; Elihu H Estey; Charles Alan Schiffer; Hartmut Doehner; Martin S Tallman; T Andrew Lister; Francesco Lo Coco; Rein Willemze; Andrea Biondi; Wolfgang Hiddemann; Richard A Larson; Bob Löwenberg; Miguel A Sanz; David R Head; Ryuzo Ohno; Clara D Bloomfield; Francesco LoCocco
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(24):4642-9.
2003: Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Claudia Erpelinck; Bob Löwenberg; Ruud Delwel
Low expression of MDS1-EVI1-like-1 (MEL1) and EVI1-like-1 (EL1) genes in favorable-risk acute myeloid leukemia.
Experimental hematology 2003;31(11):1066-72.
2003: Ellen Meijer; Jan J Cornelissen; Bob Löwenberg; Leo F Verdonck
Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell-depleted grafts from matched unrelated donors: a dose-finding study.
Experimental hematology 2003;31(11):1026-30.
2003: Bob Löwenberg
Minimal residual disease in chronic myeloid leukemia.
The New England journal of medicine 2003;349(15):1399-401.
2003: Jan J Cornelissen; Bronno van der Holt; Eefke J Petersen; Lars Vindelov; Charlotte A Russel; Martin Höglund; Johan Maertens; Harry C Schouten; Eric Braakman; Monique M C Steijaert; Mark J M Zijlmans; Ineke Slaper-Cortenbach; Marc Boogaerts; Bob Löwenberg; Leo F Verdonck
A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies.
Experimental hematology 2003;31(10):855-64.
2003: Dianne L Commeren; Peter L Van Soest; Khalil Karimi; Bob Löwenberg; Jan J Cornelissen; Eric Braakman
Paradoxical effects of interleukin-10 on the maturation of murine myeloid dendritic cells.
Immunology 2003;110(2):188-96.
2003: Cindy van Pelt; Jan Nouwen; Elly Lugtenburg; Cindy van der Schee; Siem de Marie; Paula Schuijff; Henri A Verbrugh; Bob Löwenberg; Alex Van Belkum; Margreet Vos
Strict infection control measures do not prevent clonal spread of coagulase negative staphylococci colonizing central venous catheters in neutropenic hemato-oncologic patients.
FEMS immunology and medical microbiology 2003;38(2):153-8.
2003: Bob Löwenberg; Wim L J van Putten; Matthias Theobald; Jürg Gmür; Leo F Verdonck; Pieter Sonneveld; Martin Fey; Harry Schouten; Georgine E De Greef; Augustin Ferrant; Tibor J Kovacsovics; Alois Gratwohl; S M G J Daenen; Peter C Huijgens; Marc Boogaerts
Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia.
The New England journal of medicine 2003;349(8):743-52.
2003: Annoek E C Broers; Sandra J Posthumus-van Sluijs; Hergen Spits; Bronno van der Holt; Bob Löwenberg; Eric Braakman; Jan J Cornelissen
Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants.
Blood 2003;102(4):1534-40.
2003: Rory S Care; Peter J M Valk; Anne C Goodeve; Faisel M Abu-Duhier; Wendy M C Geertsma-Kleinekoort; Gill A Wilson; Mamdooh A Gari; Ian R Peake; Bob Löwenberg; John T Reilly
Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.
British journal of haematology 2003;121(5):775-7.
2003: Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Claudia Erpelinck; Wim L J van Putten; Peter J M Valk; Sonja van der Poel-van de Luytgaarde; Ronald Hack; Rosalyn Slater; Elisabeth M E Smit; Berna Beverloo; Gregor Verhoef; Leo F Verdonck; Gert Ossenkoppele; Pieter Sonneveld; Georgine E De Greef; Bob Löwenberg; Ruud Delwel
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.
Blood 2003;101(3):837-45.
2003: Bob Löwenberg; James D Griffin; Martin S Tallman
Acute myeloid leukemia and acute promyelocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():82-101.
2003: Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Claudia Erpelinck; Joost Meijer; Susanna van Oosterhoud; Wim L J van Putten; Peter J M Valk; H Berna Beverloo; Daniel G Tenen; Bob Löwenberg; Ruud Delwel
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.
The hematology journal : the official journal of the European Haematology Association / EHA 2003;4(1):31-40.
2002: Marieke Joosten; Yolanda Vankan-Berkhoudt; Marjolein Tas; Monja Lunghi; Yvonne Bastiaansen-Jenniskens; Evan Parganas; Peter J M Valk; Bob Löwenberg; Eric van den Akker; Ruud Delwel
Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites.
Oncogene 2002;21(47):7247-55.
2002: Michel van Agthoven; Martijn T Groot; Leo F Verdonck; Bob Löwenberg; A V M B Schattenberg; Machteld Oudshoorn; Anton Hagenbeek; Jan J Cornelissen; Carin A Uyl-de Groot; R Willemze
Cost analysis of HLA-identical sibling and voluntary unrelated allogeneic bone marrow and peripheral blood stem cell transplantation in adults with acute myelocytic leukaemia or acute lymphoblastic leukaemia.
Bone marrow transplantation 2002;30(4):243-51.
2002: Bert A van der Reijden; Annet Simons; Erna Luiten; Sonja C van der Poel; Pauline E Hogenbirk; Evelyn Tönnissen; Peter J M Valk; Bob Löwenberg; Georgine E De Greef; Martijn H Breuning; Joop H Jansen
Minimal residual disease quantification in patients with acute myeloid leukaemia and inv(16)/CBFB-MYH11 gene fusion.
British journal of haematology 2002;118(2):411-8.
2002: Annoek E C Broers; Jules P P Meijerink; Jacques J M van Dongen; Sandra J Posthumus; Bob Löwenberg; Eric Braakman; Jan J Cornelissen
Quantification of newly developed T cells in mice by real-time quantitative PCR of T-cell receptor rearrangement excision circles.
Experimental hematology 2002;30(7):745-50.
2002: Joost W J van Esser; Hubert G M Niesters; Bronno van der Holt; Ellen Meijer; Albert D M E Osterhaus; Jan W Gratama; Leo F Verdonck; Bob Löwenberg; Jan J Cornelissen
Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation.
Blood 2002;99(12):4364-9.
2002: Meritxell Alberich Jordà; Sandra E Verbakel; Peter J M Valk; Yolanda Vankan-Berkhoudt; Mauro Maccarrone; Allessandro Finazzi-Agrò; Bob Löwenberg; Ruud Delwel
Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol.
Blood 2002;99(8):2786-93.
2002: Marieke Joosten; Peter J M Valk; Meritxell Alberich Jordà; Yolanda Vankan-Berkhoudt; Sandra E Verbakel; Marion van den Broek; Antoinette Beijen; Bob Löwenberg; Ruud Delwel
Leukemic predisposition of pSca-1/Cb2 transgenic mice.
Experimental hematology 2002;30(2):142-9.
2002: Sigrid P M A Oomen; Paula B van Hennik; Claudia Antonissen; Elgin G R Lichtenauer-Kaligis; Leo J Hofland; Steven W J Lamberts; Bob Löwenberg; Ivo P Touw
Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells.
Experimental hematology 2002;30(2):116-25.
2002: J A E Somers; S O A Shamelian; Bob Löwenberg; Gert Ossenkoppele; Jan J Cornelissen
[STI571: a new dimension in the treatment of chronic myeloid leukemia].
Nederlands tijdschrift voor geneeskunde 2002;146(3):128-32.
2001: Alex Van Belkum; W H F Goessens; Cindy van der Schee; Nicole Lemmens-Den Toom; Margreet C Vos; J Cornelissen; Elly Lugtenburg; Siem de Marie; Henri A Verbrugh; Bob Löwenberg; Hubert P Endtz
Rapid emergence of ciprofloxacin-resistant enterobacteriaceae containing multiple gentamicin resistance-associated integrons in a Dutch hospital.
Emerging infectious diseases 2001;7(5):862-71.
2001: Jan W Gratama; Joost W J van Esser; Cor H J Lamers; C Tournay; Bob Löwenberg; Reinder L H Bolhuis; Jan J Cornelissen
Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection.
Blood 2001;98(5):1358-64.
2001: Sigrid P M A Oomen; Leo J Hofland; Steven W J Lamberts; Bob Löwenberg; Ivo P Touw
Internalization-defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells.
FEBS letters 2001;503(2-3):163-7.
2001: Joost W J van Esser; Bronno van der Holt; Ellen Meijer; Hubert G M Niesters; Rudolf Trenschel; S F T Thijsen; Anton M van Loon; F Frassoni; A Bacigalupo; Ulrich W Schaefer; Albert D M E Osterhaus; Jan W Gratama; Bob Löwenberg; Leo F Verdonck; Jan J Cornelissen
Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell--depleted SCT.
Blood 2001;98(4):972-8.
2001: Bob Löwenberg
Managing therapy in older adult patients with acute myeloid leukemia.
Seminars in hematology 2001;38(3 Suppl 6):10-6.
2001: W J C Rombouts; Bob Löwenberg; Wim L J van Putten; Rob E Ploemacher
Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene.
Leukemia 2001;15(7):1046-53.
2001: Eric L Sievers; Richard A Larson; Edward A Stadtmauer; E Estey; Bob Löwenberg; Hervé Dombret; Chatchada Karanes; M Theobald; John M Bennett; Matthew L Sherman; Mark S Berger; Catharine B Eten; Michael R Loken; Jacques J M van Dongen; Irwin D Bernstein; Frederick R Appelbaum
Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(13):3244-54.
2001: Joost W J van Esser; Hubert G M Niesters; S F T Thijsen; Ellen Meijer; Albert D M E Osterhaus; K C Wolthers; C A Boucher; Jan W Gratama; L M Budel; Bronno van der Holt; Anton M van Loon; Bob Löwenberg; Leo F Verdonck; Jan J Cornelissen
Molecular quantification of viral load in plasma allows for fast and accurate prediction of response to therapy of Epstein-Barr virus-associated lymphoproliferative disease after allogeneic stem cell transplantation.
British journal of haematology 2001;113(3):814-21.
2001: Sigrid P M A Oomen; Elgin G R Lichtenauer-Kaligis; N Verplanke; J Hofland; Steven W J Lamberts; Bob Löwenberg; Ivo P Touw
Somatostatin induces migration of acute myeloid leukemia cells via activation of somatostatin receptor subtype 2.
Leukemia 2001;15(4):621-7.
2001: Pieternella J Lugtenburg; Eric P Krenning; Roelf Valkema; Hong-Yoe Oei; Steven W J Lamberts; Marinus Eijkemans; Wim L J van Putten; Bob Löwenberg
Somatostatin receptor scintigraphy useful in stage I-II Hodgkin's disease: more extended disease identified.
British journal of haematology 2001;112(4):936-44.
2001: Pieternella J Lugtenburg; Bob Löwenberg; Roelf Valkema; Hong-Yoe Oei; Steven W J Lamberts; Marinus Eijkemans; Wim L J van Putten; Eric P Krenning
Somatostatin receptor scintigraphy in the initial staging of low-grade non-Hodgkin's lymphomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(2):222-9.
2001: Sigrid P M A Oomen; Alister Ward; Leo J Hofland; Steven W J Lamberts; Bob Löwenberg; Ivo P Touw
Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(5):322-9.
2001: Bert A van der Reijden; L de Wit; Sonja C van der Poel; E B Luiten; Marina Lafage-Pochitaloff; Nicole Dastugue; Jean Gabert; Bob Löwenberg; Joop H Jansen
Identification of a novel CBFB-MYH11 transcript: implications for RT-PCR diagnosis.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(3):206-9.
2001: Joop H Jansen; Bob Löwenberg
Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein.
Seminars in hematology 2001;38(1):37-41.
2000: Thamar B van Dijk; emile van den akker; M P Amelsvoort; H Mano; Bob Löwenberg; Marieke von Lindern
Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.
Blood 2000;96(10):3406-13.
2000: Marieke von Lindern; Martine Parren-van Amelsvoort; Thamar B van Dijk; Eva Maria Deiner ; emile van den akker; Sjenet E van Emst-De Vries; Peter Willems; Hartmut Beug; Bob Löwenberg
Protein kinase C alpha controls erythropoietin receptor signaling.
The Journal of biological chemistry 2000;275(44):34719-27.
2000: D Louz; M van den Broek; Sandra E Verbakel; Y Vankan; Kirsten van Lom; Marieke Joosten; Dies Meijer; Bob Löwenberg; Ruud Delwel
Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice.
Leukemia 2000;14(11):1876-84.
2000: M P de Vetten; Joop H Jansen; Bert A van der Reijden; M S Berger; J M Zijlmans; Bob Löwenberg
Molecular remission of Philadelphia/bcr-abl-positive acute myeloid leukaemia after treatment with anti-CD33 calicheamicin conjugate (gemtuzumab ozogamicin, CMA-676).
British journal of haematology 2000;111(1):277-9.
2000: Jeanette K Doorduijn; P Spruit; Bronno van der Holt; Mars B van't Veer; L Budel; Bob Löwenberg; Pieter Sonneveld
Etoposide, mitoxantrone and prednisone: a salvage regimen with low toxicity for refractory or relapsed non-Hodgkin's lymphoma.
Haematologica 2000;85(8):814-9.
2000: M C Breems-de Ridder; Bob Löwenberg; Joop H Jansen
Retinoic acid receptor fusion proteins: friend or foe.
Molecular and cellular endocrinology 2000;165(1-2):1-6.
2000: JP de Koning; AA Soede-Bobok; Alister Ward; AM Schelen; Claudia Antonissen; Daphne van Leeuwen; Bob Löwenberg; Ivo P Touw
STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1).
Oncogene 2000;19(29):3290-8.
2000: Henk J Broxterman; Pieter Sonneveld; W J van Putten; Jan Lankelma; CA Eekman; Gert Ossenkoppele; HERBERT PINEDO; Bob Löwenberg; Gerrit J Schuurhuis
P-glycoprotein in primary acute myeloid leukemia and treatment outcome of idarubicin/cytosine arabinoside-based induction therapy.
Leukemia 2000;14(6):1018-24.
2000: W J C Rombouts; I Blokland; Bob Löwenberg; Rob E Ploemacher
Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene.
Leukemia 2000;14(4):675-83.
2000: Annoek E C Broers; R van Der Holt; Joost W J van Esser; Jan W Gratama; SC Henzen-Logmans; V Kuenen-Boumeester; Bob Löwenberg; Jan J Cornelissen
Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation.
Blood 2000;95(7):2240-5.
2000: Marieke Joosten; Peter J M Valk; Y Vankan; NJ de Both; Bob Löwenberg; Ruud Delwel
Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from a novel panel of cas-Br-M murine leukemia virus-infected mice.
Virology 2000;268(2):308-18.
2000: Pieter Sonneveld; A Burnett; P Vossebeld; Monique Ben-Am; G Rosenkranz; C Pfister; G Verhoef; A Dekker; G Ossenkoppele; C Ferrant; L Yin; Alois Gratwohl; Tibor J Kovacsovics; E Vellenga; Renaud Capdeville; Bob Löwenberg
Dose-finding study of valspodar (PSC 833) with daunorubicin and cytarabine to reverse multidrug resistance in elderly patients with previously untreated acute myeloid leukemia.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(6):411-21.
2000: Peter J M Valk; Sandra E Verbakel; Marieke von Lindern; Bob Löwenberg; Ruud Delwel
Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(4):254-63.
2000: JP de Koning; Alister Ward; E Caldenhoven; RP de Groot; Bob Löwenberg; Ivo P Touw
STAT3beta does not interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiation.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(4):220-5.
1999: Bob Löwenberg; J R Downing; A Burnett
Acute myeloid leukemia.
The New England journal of medicine 1999;341(14):1051-62.
1999: Gert Ossenkoppele; Bronno van der Holt; Gregor Verhoef; S M G J Daenen; Leo F Verdonck; Pieter Sonneveld; Pierre W Wijermans; Johannes Van Der Lelie; Wim L J van Putten; Bob Löwenberg
A randomized study of granulocyte colony-stimulating factor applied during and after chemotherapy in patients with poor risk myelodysplastic syndromes: a report from the HOVON Cooperative Group. Dutch-Belgian Hemato-Oncology Cooperative Group.
Leukemia 1999;13(8):1207-13.
1999: Kirsten van Lom; A B Houtsmuller; W L van Putten; Rosalyn M Slater; Bob Löwenberg
Cytogenetic clonality analysis of megakaryocytes in myelodysplastic syndrome by dual-color fluorescence in situ hybridization and confocal laser scanning microscopy.
Genes, chromosomes & cancer 1999;25(4):332-8.
1999: Marieke von Lindern; W Zauner; G Mellitzer; Peter Steinlein; G Fritsch; K Huber; Bob Löwenberg; Hartmut Beug
The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro.
Blood 1999;94(2):550-9.
1999: M C de Ridder; A J van der Plas; Claudia A J Erpelinck-Verschueren; Bob Löwenberg; Joop H Jansen
Dexamethasone does not counteract the response of acute promyelocytic leukaemia cells to all-trans retinoic acid.
British journal of haematology 1999;106(1):107-10.
1999: Bert A van der Reijden; Claudia A J Erpelinck-Verschueren; Bob Löwenberg; Joop H Jansen
TRIADs: a new class of proteins with a novel cysteine-rich signature.
Protein science : a publication of the Protein Society 1999;8(7):1557-61.
1999: Joop H Jansen; M C de Ridder; W M Geertsma; Claudia Erpelinck; Kirsten van Lom; Elisabeth M E Smit; Rosalyn Slater; B A vd Reijden; Georgine E De Greef; Pieter Sonneveld; Bob Löwenberg
Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor.
Blood 1999;94(1):39-45.
1999: Edo Vellenga; Wim L J van Putten; Marc Boogaerts; S M G J Daenen; Gregor Verhoef; Anton Hagenbeek; Andries R Jonkhoff; Peter C Huijgens; Leo F Verdonck; Johannes Van Der Lelie; Harry C Schouten; Jürg Gmür; Pierre W Wijermans; Alois Gratwohl; U Hess; M F Fey; Bob Löwenberg
Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?
Bone marrow transplantation 1999;23(12):1279-82.
1999: Peter J M Valk; Y Vankan; Marieke Joosten; N A Jenkins; N G Copeland; Bob Löwenberg; Ruud Delwel
Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.
Journal of virology 1999;73(5):3595-602.
1999: Christine M Segeren; Pieter Sonneveld; Bronno van der Holt; Joke W Baars; Douwe H Biesma; J J Cornellissen; Alexandra J Croockewit; Adriaan W Dekker; W E Fibbe; Bob Löwenberg; Marinus van Marwijk Kooy; Marinus H J van Oers; D J Richel; H C Schouten; Edo Vellenga; Gregor Verhoef; Pierre W Wijermans; Shulamiet Wittebol; Henk M Lokhorst
Vincristine, doxorubicin and dexamethasone (VAD) administered as rapid intravenous infusion for first-line treatment in untreated multiple myeloma.
British journal of haematology 1999;105(1):127-30.
1999: Henk J Broxterman; Pieter Sonneveld; Rob Pieters; Jan Lankelma; CA Eekman; Anne H Loonen; M Schoester; Gert Ossenkoppele; Bob Löwenberg; HERBERT PINEDO; Gerrit J Schuurhuis
Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia?
Leukemia 1999;13(2):258-65.
1998: Henk Rozemuller; W Terpstra; Elwin J C Rombouts; Mark Lawler; C Byrne; DJ FitzGerald; Robert J Kreitman; JJ Wielenga; Bob Löwenberg; Ivo P Touw; Anton Hagenbeek; Anton Martens
GM-CSF receptor targeted treatment of primary AML in SCID mice using Diphtheria toxin fused to huGM-CSF.
Leukemia 1998;12(12):1962-70.
1998: Mirjam H A Hermans; Alister Ward; Claudia Antonissen; Alar Karis; Bob Löwenberg; Ivo P Touw
Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia.
Blood 1998;92(1):32-9.
1998: Jan J Cornelissen; Willem E Fibbe; A V M B Schattenberg; Eefke J Petersen; Rein Willemze; Theo de Witte; Bob Löwenberg; Leo F Verdonck; A vd Biezen; Ronald Brand
A retrospective Dutch study comparing T cell-depleted allogeneic blood stem cell transplantation vs T cell-depleted allogeneic bone marrow transplantation.
Bone marrow transplantation 1998;21 Suppl 3():S66-70.
1998: Pieter Sonneveld; J S Laméris; J Cornelissen; A Ogilvie; Bob Löwenberg
Color-flow imaging sonography of portal and hepatic vein flow to monitor fibrinolytic therapy with r-TPA for veno-occlusive disease following myeloablative treatment.
Bone marrow transplantation 1998;21(7):731-4.
1998: Carin A Uyl-de Groot; Bob Löwenberg; Edo Vellenga; Stefan Suciu; R Willemze; Frans F H Rutten
Cost-effectiveness and quality-of-life assessment of GM-CSF as an adjunct to intensive remission induction chemotherapy in elderly patients with acute myeloid leukemia.
British journal of haematology 1998;100(4):629-36.
1998: Bob Löwenberg; Stefan Suciu; Eric Archimbaud; H Haak; Pierre Stryckmans; R de Cataldo; Adriaan W Dekker; Z N Berneman; Antoine Thyss; Johannes Van Der Lelie; Pieter Sonneveld; G Visani; George Fillet; M Hayat; Anne Hagemeijer; G Solbu; Robert Zittoun
Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy--the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(3):872-81.
1998: Bob Löwenberg; W Terpstra
Maturation hierarchy of leukemic stem cells.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():85-8; discussion 89.
1997: Bob Löwenberg; Marc Boogaerts; S M G J Daenen; Gregor Verhoef; Anton Hagenbeek; Edo Vellenga; Gert Ossenkoppele; Peter C Huijgens; Leo F Verdonck; Johannes Van Der Lelie; JJ Wielenga; Harry C Schouten; Jürg Gmür; Alois Gratwohl; U Hess; M F Fey; Wim L J van Putten
Value of different modalities of granulocyte-macrophage colony-stimulating factor applied during or after induction therapy of acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(12):3496-506.
1997: W Terpstra; Henk Rozemuller; DA Breems; Elwin J C Rombouts; A Prins; DJ FitzGerald; Robert J Kreitman; JJ Wielenga; Rob E Ploemacher; Bob Löwenberg; Anton Hagenbeek; Anton Martens
Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells.
Blood 1997;90(9):3735-42.
1997: Peter J M Valk; Marieke Joosten; Y Vankan; Bob Löwenberg; Ruud Delwel
A rapid RT-PCR based method to isolate complementary DNA fragments flanking retrovirus integration sites.
Nucleic acids research 1997;25(21):4419-21.
1997: Bob Löwenberg; Stefan Suciu; Eric Archimbaud; Gert Ossenkoppele; Gregor Verhoef; E Vellenga; Pierre W Wijermans; Zwi Berneman; Adriaan W Dekker; Pierre Stryckmans; Harry Schouten; Ulrich Jehn; Petra Muus; Pieter Sonneveld; M Dardenne; Robert Zittoun
Use of recombinant GM-CSF during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia: final report of AML-11, a phase III randomized study of the Leukemia Cooperative Group of European Organisation for the Research and Treatment of Cancer and the Dutch Belgian Hemato-Oncology Cooperative Group.
Blood 1997;90(8):2952-61.
1997: Marry M van den Heuvel-Eibrink; Bronno van der Holt; P A W te Boekhorst; Rob Pieters; Martijn Schoester; Bob Löwenberg; Pieter Sonneveld
MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia.
British journal of haematology 1997;99(1):76-83.
1997: Peter J M Valk; S Hol; Y Vankan; J N Ihle; D Askew; N A Jenkins; D J Gilbert; N G Copeland; NJ de Both; Bob Löwenberg; Ruud Delwel
The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.
Journal of virology 1997;71(9):6796-804.
1997: Peter J M Valk; Sandra E Verbakel; Y Vankan; S Hol; S Mancham; Rob E Ploemacher; AE Mayen; Bob Löwenberg; Ruud Delwel
Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells.
Blood 1997;90(4):1448-57.
1997: G S Liem; J J Cornelissen; Machteld Oudshoorn; Kees Sintnicolaas; Bob Löwenberg; A Hagenbeek
[Allogeneic bone marrow transplantation of unrelated donors; fewer complication, more donors].
Nederlands tijdschrift voor geneeskunde 1997;141(32):1553-6.
1997: W Terpstra; Pieter J M Leenen; C van den Bos; A Prins; W A Loenen; Monique M A Verstegen; S van Wyngaardt; N van Rooijen; Albertus W Wognum; Gerard Wagemaker; JJ Wielenga; Bob Löwenberg
Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes.
Leukemia 1997;11(7):1049-54.
1997: W Terpstra; Bob Löwenberg
Application of myeloid growth factors in the treatment of acute myeloid leukemia.
Leukemia 1997;11(3):315-27.
1997: Lies Hoefsloot; M P van Amelsvoort; L C Broeders; D C van der Plas; Kirsten van Lom; H Hoogerbrugge; Ivo P Touw; Bob Löwenberg
Erythropoietin-induced activation of STAT5 is impaired in the myelodysplastic syndrome.
Blood 1997;89(5):1690-700.
1997: Adriaan W Dekker; Mars B van't Veer; W Sizoo; H L Haak; Johannes Van Der Lelie; Gert Ossenkoppele; Peter C Huijgens; Harry C Schouten; Pieter Sonneveld; Rein Willemze; Leo F Verdonck; Wim L J van Putten; Bob Löwenberg
Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Dutch Hemato-Oncology Research Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(2):476-82.
1997: Kirsten van Lom; Anne Hagemeijer; F Vandekerckhove; Georgine E De Greef; Nicoletta Sacchi; Bob Löwenberg
Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone.
Leukemia 1997;11(2):202-5.
1997: Bob Löwenberg; Wim L J van Putten; A Ferrant; Gert Ossenkoppele; Edo Vellenga; Leo F Verdonck; A Gratwohl; M A Boogaerts
Peripheral blood progenitor cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia.
Stem cells (Dayton, Ohio) 1997;15 Suppl 1():177-80; discussion 181.
1997: Jan J Cornelissen; Albertus W Wognum; Rob E Ploemacher; F Frassoni; Gerard Wagemaker; A Hagemeijer; Bob Löwenberg
Efficient long-term maintenance of chronic myeloid leukemic cobblestone area forming cells on a murine stromal cell line.
Leukemia 1997;11(1):126-33.
1997: Fan Dong; D C Dale; M A Bonilla; M Freedman; A Fasth; H J Neijens; J Palmblad; G L Briars; G Carlsson; A J Veerman; K Welte; Bob Löwenberg; Ivo P Touw
Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia.
Leukemia 1997;11(1):120-5.
1996: J K Doorduijn; Kirsten van Lom; Bob Löwenberg
Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years.
British journal of haematology 1996;95(3):531-4.
1996: Pieter Sonneveld; J P Marie; C Huisman; A Vekhoff; M Schoester; A M Faussat; J van Kapel; A Groenewegen; S Charnick; R Zittoun; Bob Löwenberg
Reversal of multidrug resistance by SDZ PSC 833, combined with VAD (vincristine, doxorubicin, dexamethasone) in refractory multiple myeloma. A phase I study.
Leukemia 1996;10(11):1741-50.
1996: W Terpstra; Rob E Ploemacher; A Prins; Kirsten van Lom; K Pouwels; Albertus W Wognum; Gerard Wagemaker; Bob Löwenberg; JJ Wielenga
Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture.
Blood 1996;88(6):1944-50.
1996: P J van den Anker-Lugtenburg; Bob Löwenberg; Steven W J Lamberts; Eric P Krenning
The relevance of somatostatin receptor expression in malignant lymphomas.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):96-7.
1996: D C van der Plas; F Smiers; K Pouwels; Lies Hoefsloot; Bob Löwenberg; Ivo P Touw
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.
Leukemia 1996;10(8):1317-25.
1996: Stefan Fruehauf; DA Breems; S Knaän-Shanzer; K B Brouwer; Rainer Haas; Bob Löwenberg; K Nooter; Rob E Ploemacher; Dinko Valerio; J J Boesen
Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123.
Human gene therapy 1996;7(10):1219-31.
1996: Kirsten van Lom; Anne Hagemeijer; F Vandekerckhove; Elisabeth M E Smit; Bob Löwenberg
Cytogenetic clonality analysis: typical patterns in myelodysplastic syndrome and acute myeloid leukaemia.
British journal of haematology 1996;93(3):594-600.
1996: P J van den Anker-Lugtenburg; F Heule; P M Vanhagen; Theodoor Van Joost; H Y Oei; Bob Löwenberg; Eric P Krenning
Somatostatin receptor scintigraphy in cutaneous malignant lymphomas.
Journal of the American Academy of Dermatology 1996;34(6):985-93.
1996: Henk J Broxterman; Pieter Sonneveld; Nicole Feller; Gert Ossenkoppele; D C Währer; CA Eekman; M Schoester; Jan Lankelma; HERBERT PINEDO; Bob Löwenberg; Gerrit J Schuurhuis
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Blood 1996;87(11):4809-16.
1996: P J van den Anker-Lugtenburg; Eric P Krenning; H Y Oei; M P Van Hagen; C J Gerrits; J C Reubi; Steven W J Lamberts; Bob Löwenberg
Somatostatin receptor scintigraphy in the initial staging of Hodgkin's disease.
British journal of haematology 1996;93(1):96-103.
1996: F J Smiers; M van Paassen; Karel Hählen; Bob Löwenberg; Ivo P Touw
CD20 and CD40 mediated mitogenic responses in B-lineage acute lymphoblastic leukaemia.
British journal of haematology 1996;93(1):125-30.
1996: W Terpstra; A Prins; Rob E Ploemacher; B W Wognum; Gerard Wagemaker; Bob Löwenberg; JJ Wielenga
Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia.
Blood 1996;87(6):2187-94.
1996: R M Barge; JP de Koning; K Pouwels; Fan Dong; Bob Löwenberg; Ivo P Touw
Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route.
Blood 1996;87(6):2148-53.
1996: Bob Löwenberg
Treatment of the elderly patient with acute myeloid leukaemia.
Baillière's clinical haematology 1996;9(1):147-59.
1996: B Backx; L Broeders; Lies Hoefsloot; B Wognum; Bob Löwenberg
Erythropoiesis in myelodysplastic syndrome: expression of receptors for erythropoietin and kit ligand.
Leukemia 1996;10(3):466-72.
1996: JP de Koning; Fan Dong; L Smith; AM Schelen; R M Barge; D C van der Plas; Lies Hoefsloot; Bob Löwenberg; Ivo P Touw
The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation.
Blood 1996;87(4):1335-42.
1996: Fan Dong; K Pouwels; Lies Hoefsloot; Henk Rozemuller; Bob Löwenberg; Ivo P Touw
The C-terminal cytoplasmic region of the granulocyte colony-stimulating factor receptor mediates apoptosis in maturation-incompetent murine myeloid cells.
Experimental hematology 1996;24(2):214-20.
1996: Edo Vellenga; Carin A Uyl-de Groot; R de Wit; H J Keizer; Bob Löwenberg; M A ten Haaft; Theo de Witte; C A Verhagen; Gerrit Stoter; Frans F H Rutten; Nanno H Mulder; w martin smid; Elisabeth G E de Vries
Randomized placebo-controlled trial of granulocyte-macrophage colony-stimulating factor in patients with chemotherapy-related febrile neutropenia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(2):619-27.
1996: J J Wielenga; Edo Vellenga; A Groenewegen; Pieter Sonneveld; Bob Löwenberg
Recombinant human interleukin-3 (rH IL-3) in combination with remission induction chemotherapy in patients with relapsed acute myelogenous leukemia (AML): a phase I/II study.
Leukemia 1996;10(1):43-7.
1996: JP de Koning; AM Schelen; Fan Dong; C van Buitenen; B M Burgering; J L Bos; Bob Löwenberg; Ivo P Touw
Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes.
Blood 1996;87(1):132-40.
1995: Stefan Fruehauf; J J Boesen; DA Breems; R Höft; P Hundsdörfer; W Jens Zeller; Bob Löwenberg; Rob E Ploemacher; Rainer Haas; Dinko Valerio
Retroviral transfer of the multidrug resistance-1 gene into lineage-committed and primitive hemopoietic cells.
Stem cells (Dayton, Ohio) 1995;13 Suppl 3():93-9.
1995: Kirsten van Lom; Anne Hagemeijer; E Smit; K Hählen; Kees Groeneveld; Bob Löwenberg
Cytogenetic clonality analysis in myelodysplastic syndrome: monosomy 7 can be demonstrated in the myeloid and in the lymphoid lineage.
Leukemia 1995;9(11):1818-21.
1995: Carin A Uyl-de Groot; Anton Hagenbeek; L F Verdonck; Bob Löwenberg; Frans F H Rutten
Cost-effectiveness of ABMT in comparison with CHOP chemotherapy in patients with intermediate- and high-grade malignant non-Hodgkin's lymphoma (NHL).
Bone marrow transplantation 1995;16(3):463-70.
1995: W Terpstra; A Prins; Trudi P Visser; B Wognum; Gerard Wagemaker; Bob Löwenberg; JJ Wielenga
Conditions for engraftment of human acute myeloid leukemia (AML) in SCID mice.
Leukemia 1995;9(9):1573-7.
1995: Fan Dong; R K Brynes; N Tidow; Karl Welte; Bob Löwenberg; Ivo P Touw
Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia.
The New England journal of medicine 1995;333(8):487-93.
1995: F J Smiers; M van Paassen; K Pouwels; Auke Beishuizen; Karel Hählen; Bob Löwenberg; Ivo P Touw
Heterogeneity of proliferative responses of human B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells to interleukin 7 (IL-7): no correlation with immunoglobulin gene status and expression of IL-7 receptor or IL-2/IL-4/IL-7 receptor common gamma chain genes.
Leukemia 1995;9(6):1039-45.
1995: P A te Boekhorst; Bob Löwenberg; J van Kapel; Kees Nooter; Pieter Sonneveld
Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia.
Leukemia 1995;9(6):1025-31.
1995: L M Budel; Fan Dong; Bob Löwenberg; Ivo P Touw
Hematopoietic growth factor receptors: structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders.
Leukemia 1995;9(4):553-61.
1995: Carin A Uyl-de Groot; S Y Okhuijsen; Anton Hagenbeek; Peter C Huijgens; G W van Imhoff; Bob Löwenberg; L F Verdonck; Frans F H Rutten
Costs of introducing autologous BMT in the treatment of lymphoma and acute leukaemia in The Netherlands.
Bone marrow transplantation 1995;15(4):605-10.
1995: Fan Dong; M van Paassen; C van Buitenen; Lies Hoefsloot; Bob Löwenberg; Ivo P Touw
A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform.
Blood 1995;85(4):902-11.
1994: C J Gerrits; Hans van Overhagen; Kirsten van Lom; H J Adriaansen; Bob Löwenberg
Ultrasound examination of pathological cervical lymph nodes in patients with non-Hodgkin's lymphoma and Hodgkin's disease.
British journal of haematology 1994;88(3):626-8.
1994: L T Vlasveld; T A Splinter; Anne Hagemeijer; Kirsten van Lom; Bob Löwenberg
Acute myeloid leukaemia with +i(12p) shortly after treatment of mediastinal germ cell tumour.
British journal of haematology 1994;88(1):196-8.
1994: P A te Boekhorst; Bob Löwenberg; Pieter Sonneveld
Hematopoietic growth factor stimulation and cytarabine cytotoxicity in vitro: effects in untreated and relapsed or primary refractory acute myeloid leukemia cells.
Leukemia 1994;8(9):1480-6.
1994: Fan Dong; Lies Hoefsloot; AM Schelen; C A Broeders; Y Meijer; A J Veerman; Ivo P Touw; Bob Löwenberg
Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4480-4.
1994: F C van Gils; L M Budel; H Burger; R W van Leen; Bob Löwenberg; Gerard Wagemaker
Interleukin-3 (IL-3) receptors on rhesus monkey bone marrow cells: species specificity of human IL-3, binding characteristics, and lack of competition with GM-CSF.
Experimental hematology 1994;22(3):248-55.
1994: P Martin van Hagen; Eric P Krenning; Dik J Kwekkeboom; J C Reubi; P J Anker-Lugtenburg; Bob Löwenberg; Steven W J Lamberts
Somatostatin and the immune and haematopoetic system; a review.
European journal of clinical investigation 1994;24(2):91-9.
1993: Fan Dong; C van Buitenen; K Pouwels; Lies Hoefsloot; Bob Löwenberg; Ivo P Touw
Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.
Molecular and cellular biology 1993;13(12):7774-81.
1993: P A te Boekhorst; K de Leeuw; M Schoester; S Wittebol; Kees Nooter; Anne Hagemeijer; Bob Löwenberg; Pieter Sonneveld
Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells.
Blood 1993;82(10):3157-62.
1993: P A te Boekhorst; Bob Löwenberg; Pieter Sonneveld
Enhanced chemosensitivity in acute myeloid leukemia by hematopoietic growth factors: a comparison of the MTT assay with a clonogenic assay.
Leukemia 1993;7(10):1637-44.
1993: Kirsten van Lom; Anne Hagemeijer; Elisabeth M E Smit; Bob Löwenberg
In situ hybridization on May-Grünwald Giemsa-stained bone marrow and blood smears of patients with hematologic disorders allows detection of cell-lineage-specific cytogenetic abnormalities.
Blood 1993;82(3):884-8.
1993: P A te Boekhorst; Bob Löwenberg; M Vlastuin; Pieter Sonneveld
Enhanced chemosensitivity of clonogenic blasts from patients with acute myeloid leukemia by G-CSF, IL-3 or GM-CSF stimulation.
Leukemia 1993;7(8):1191-8.
1993: Mars B van't Veer; Wim L J van Putten; Leo F Verdonck; Gert Ossenkoppele; Bob Löwenberg; Johanna C Kluin-Nelemans; P W Wijermans; Harry C Schouten; W Sizoo; Adriaan W Dekker
Acute lymphoblastic leukaemia in adults: immunological subtypes and clinical features at presentation.
Annals of hematology 1993;66(6):277-82.
1993: L M Budel; H Hoogerbrugge; K Pouwels; C van Buitenen; Ruud Delwel; Bob Löwenberg; Ivo P Touw
Granulocyte-macrophage colony-stimulating factor receptors alter their binding characteristics during myeloid maturation through up-regulation of the affinity converting beta subunit (KH97).
The Journal of biological chemistry 1993;268(14):10154-9.
1993: Bob Löwenberg; W L van Putten; Ivo P Touw; Ruud Delwel; V Santini
Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia.
The New England journal of medicine 1993;328(9):614-9.
1993: L M Budel; Ruud Delwel; C van Buitenen; H Hoogerbrugge; Bob Löwenberg
Effects of mast cell growth factor on acute myeloid leukemia cells in vitro: effects of combinations with other cytokines.
Leukemia 1993;7(3):426-34.
1993: Bob Löwenberg; Ivo P Touw
Hematopoietic growth factors and their receptors in acute leukemia.
Blood 1993;81(2):281-92.
1993: B Backx; L Broeders; Ivo P Touw; Bob Löwenberg
Blast colony-forming cells in myelodysplastic syndrome: decreased potential to generate erythroid precursors.
Leukemia 1993;7(1):75-9.
1993: Bob Löwenberg
Leukemia and myelodysplasia.
Cancer chemotherapy and biological response modifiers 1993;14():371-82.
1993: P M Vanhagen; Eric P Krenning; J C Reubi; A H Mulder; Willem H Bakker; H Y Oei; Bob Löwenberg; Steven W J Lamberts
Somatostatin analogue scintigraphy of malignant lymphomas.
British journal of haematology 1993;83(1):75-9.
1992: G J Creemers; Bob Löwenberg; A Hagenbeek
Allogeneic bone marrow transplantation for primary myelofibrosis.
British journal of haematology 1992;82(4):772-3.
1992: Ruud Delwel; C van Buitenen; Bob Löwenberg; Ivo P Touw
Involvement of tumor necrosis factor (TNF) receptors p55 and p75 in TNF responses of acute myeloid leukemia blasts in vitro.
Blood 1992;80(7):1798-803.
1992: B Backx; L Broeders; Bob Löwenberg
Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome.
Blood 1992;80(5):1213-7.
1992: O Elbaz; L A Mahmoud; Ivo P Touw; Bob Löwenberg
Analysis of the TNF receptors on human leukaemia cells by affinity cross-linking.
British journal of haematology 1992;81(4):530-2.
1992: Ivo P Touw; Ruud van Gurp; P Schipper; Ton van Agthoven; Bob Löwenberg
Introduction of the human interleukin-6 (IL-6) receptor in murine IL-3-dependent hematopoietic cells restores responsiveness to IL-6.
Blood 1992;79(11):2867-72.
1991: P Colombat; V Santini; Ruud Delwel; J Krefft; J L Bredmond; Bob Löwenberg
Primary human acute myeloblastic leukaemia: an analysis of in vitro granulocytic maturation following stimulation with retinoic acid and G-CSF.
British journal of haematology 1991;79(3):382-9.
1991: Ivo P Touw; J Donath; K Pouwels; C van Buitenen; P Schipper; V Santini; Anne Hagemeijer; Bob Löwenberg; Ruud Delwel
Acute myeloid leukemias with chromosomal abnormalities involving the 21q22 region identified by their in vitro responsiveness to interleukin-5.
Leukemia 1991;5(8):687-92.
1991: O Elbaz; L M Budel; H Hoogerbrugge; Ivo P Touw; Ruud Delwel; L A Mahmoud; Bob Löwenberg
Tumor necrosis factor regulates the expression of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells.
Blood 1991;77(5):989-95.
1991: O Elbaz; L M Budel; H Hoogerbrugge; Ivo P Touw; Ruud Delwel; L A Mahmoud; Bob Löwenberg
Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.
The Journal of clinical investigation 1991;87(3):838-41.
1991: V Santini; P Colombat; Ruud Delwel; Ruud van Gurp; Ivo P Touw; Bob Löwenberg
Induction of granulocytic maturation in acute myeloid leukemia by G-CSF and retinoic acid.
Leukemia research 1991;15(5):341-50.
1991: B Backx; L Broeders; Fredrik J Bot; Bob Löwenberg
Positive and negative effects of tumor necrosis factor on colony growth from highly purified normal marrow progenitors.
Leukemia 1991;5(1):66-70.
1990: J B Ruit; Bob Löwenberg; Anton Hagenbeek; Gregor Verhoef; J J Wielenga; J Michiels; W Sizoo
Phase II study of lomustine, cytarabine, mitoxantrone, and prednisone (CAMP) combination chemotherapy for doxorubicin-resistant intermediate- and high-grade malignant non-Hodgkin's lymphoma.
Seminars in oncology 1990;17(6 Suppl 10):24-7.
1990: Ruud Delwel; C van Buitenen; M Salem; R Oosterom; Ivo P Touw; Bob Löwenberg
Hemopoietin-1 activity of interleukin-1 (IL-1) on acute myeloid leukemia colony-forming cells (AML-CFU) in vitro: IL-1 induces production of tumor necrosis factor-alpha which synergizes with IL-3 or granulocyte-macrophage colony-stimulating factor.
Leukemia 1990;4(8):557-60.
1990: Fredrik J Bot; P Schipper; L Broeders; Ruud Delwel; K Kaushansky; Bob Löwenberg
Interleukin-1 alpha also induces granulocyte-macrophage colony-stimulating factor in immature normal bone marrow cells.
Blood 1990;76(2):307-11.
1990: Ivo P Touw; K Pouwels; Ton van Agthoven; Ruud van Gurp; Ruud Delwel; A Hagemeijer; Karel Hählen; Bob Löwenberg
Role of interleukin-7 in the growth of acute lymphoblastic leukemia.
Bone marrow transplantation 1990;6 Suppl 1():36-8.
1990: Ruud Delwel; P Schipper; C van Buitenen; T van Agthoven; Ivo P Touw; Bob Löwenberg
Comparative analysis of IL-1 regulated and spontaneous growth of acute myeloid leukemia in vitro.
Bone marrow transplantation 1990;6 Suppl 1():22-6.
1990: Ivo P Touw; K Pouwels; Ton van Agthoven; Ruud van Gurp; L Budel; H Hoogerbrugge; Ruud Delwel; R Goodwin; A Namen; Bob Löwenberg
Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia.
Blood 1990;75(11):2097-101.
1990: Fredrik J Bot; L van Eijk; P Schipper; B Backx; Bob Löwenberg
Synergistic effects between GM-CSF and G-CSF or M-CSF on highly enriched human marrow progenitor cells.
Leukemia 1990;4(5):325-8.
1990: L M Budel; O Elbaz; H Hoogerbrugge; Ruud Delwel; L A Mahmoud; Bob Löwenberg; Ivo P Touw
Common binding structure for granulocyte macrophage colony-stimulating factor and interleukin-3 on human acute myeloid leukemia cells and monocytes.
Blood 1990;75(7):1439-45.
1990: Bob Löwenberg; L J Verdonck; Adriaan W Dekker; Rein Willemze; F E Zwaan; M de Planque; J Abels; Pieter Sonneveld; J van der Lelie; R Goudsmit
Autologous bone marrow transplantation in acute myeloid leukemia in first remission: results of a Dutch prospective study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(2):287-94.
1990: V Santini; K Nooter; Ruud Delwel; Bob Löwenberg
Susceptibility of acute myeloid leukemia (AML) cells from clinically resistant and sensitive patients to daunomycin (DNR): assessment in vitro after stimulation with colony stimulating factors (CSFs).
Leukemia research 1990;14(4):377-80.
1990: Bob Löwenberg; Ruud Delwel; Ivo P Touw
Hematopoietic growth factors and progenitor cells in human acute leukemia.
Immunology series 1990;49():277-96.
1990: U Jehn; R Zittoun; Stefan Suciu; D Fiere; C Haanen; M Peetermans; Bob Löwenberg; R Willemze; G Solbu; Pierre Stryckmans
A randomized comparison of intensive maintenance treatment for adult acute myelogenous leukemia using either cyclic alternating drugs or repeated courses of the induction-type chemotherapy: AML-6 trial of the EORTC Leukemia Cooperative Group.
Haematology and blood transfusion 1990;33():277-84.
1990: M Salem; Ruud Delwel; Ivo P Touw; L A Mahmoud; E M Elbasousy; Bob Löwenberg
Modulation of colony stimulating factor-(CSF) dependent growth of acute myeloid leukemia by tumor necrosis factor.
Leukemia 1990;4(1):37-43.
1989: L M Budel; Ivo P Touw; Ruud Delwel; Bob Löwenberg
Granulocyte colony-stimulating factor receptors in human acute myelocytic leukemia.
Blood 1989;74(8):2668-73.
1989: Bob Löwenberg; R Zittoun; H Kerkhofs; U Jehn; J Abels; L Debusscher; C Cauchie; M Peetermans; G Solbu; Stefan Suciu
On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(9):1268-74.
1989: Ruud Delwel; C van Buitenen; M Salem; Fredrik J Bot; S Gillis; K Kaushansky; B Altrock; Bob Löwenberg
Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release.
Blood 1989;74(2):586-93.
1989: L M Budel; Ivo P Touw; Ruud Delwel; S C Clark; Bob Löwenberg
Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response.
Blood 1989;74(2):565-71.
1989: Ivo P Touw; J Groot-Loonen; L Broeders; T van Agthoven; K Hählen; A Hagemeijer; Bob Löwenberg
Recombinant hematopoietic growth factors fail to induce a proliferative response in precursor B acute lymphoblastic leukemia.
Leukemia 1989;3(5):356-62.
1989: Fredrik J Bot; L van Eijk; P Schipper; Bob Löwenberg
Effects of human interleukin-3 on granulocytic colony-forming cells in human bone marrow.
Blood 1989;73(5):1157-60.
1989: M Salem; Ruud Delwel; L A Mahmoud; S Clark; E M Elbasousy; Bob Löwenberg
Maturation of human acute myeloid leukaemia in vitro: the response to five recombinant haematopoietic factors in a serum-free system.
British journal of haematology 1989;71(3):363-70.
1989: R Zittoun; U Jehn; D Fière; C Haanen; Bob Löwenberg; R Willemze; J Abels; J Bury; M Peetermans; M Hayat
Alternating v repeated postremission treatment in adult acute myelogenous leukemia: a randomized phase III study (AML6) of the EORTC Leukemia Cooperative Group.
Blood 1989;73(4):896-906.
1989: Fredrik J Bot; L van Eijk; P Schipper; Bob Löwenberg
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates immature marrow precursors but no CFU-GM, CFU-G, or CFU-M.
Experimental hematology 1989;17(3):292-5.
1989: Fredrik J Bot; L van Eijk; L Broeders; L A Aarden; Bob Löwenberg
Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells.
Blood 1989;73(2):435-7.
1989: Harry C Schouten; Ruud Delwel; Fredrik J Bot; A Hagemeijer; Ivo P Touw; Bob Löwenberg
Characterization of clonogenic cells in refractory anemia with excess of blasts (RAEB-CFU): response to recombinant hematopoietic growth factors and maturation phenotypes.
Leukemia research 1989;13(3):245-51.
1989: A Pulsoni; Ruud Delwel; M Salem; Ivo P Touw; Bob Löwenberg
Cell to cell contact enhances the proliferation of acute myeloid leukemia (AML) cells in vitro without an apparent role of adhesion glycoproteins LFA1, MAC1 and P150-95.
Leukemia research 1989;13(10):883-91.
1989: Bob Löwenberg; Ivo P Touw
Leukemic hematopoiesis in vitro: acute myeloid leukemia.
Bone marrow transplantation 1989;4 Suppl 1():5-8.
1989: R Moberts; H Hoogerbrugge; T van Agthoven; Bob Löwenberg; Ivo P Touw
Proliferative response of highly purified B chronic lymphocytic leukemia cells in serum free culture to interleukin-2 and tumor necrosis factors alpha and beta.
Leukemia research 1989;13(11):973-80.
1988: Ruud Delwel; M Salem; C Pellens; L Dorssers; G Wagemaker; S Clark; Bob Löwenberg
Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system.
Blood 1988;72(6):1944-9.
1988: Ruud Delwel; Ruud van Gurp; Fredrik J Bot; Ivo P Touw; Bob Löwenberg
Phenotyping of acute myelocytic leukemia (AML) progenitors: an approach for tracing minimal numbers of AML cells among normal bone marrow.
Leukemia 1988;2(12):814-9.
1988: R Willemze; U Jager; U Jehn; Pierre Stryckmans; J Bury; Stefan Suciu; G Solbu; R Zittoun; J Burghouts; Bob Löwenberg
Intermediate and high dose Ara-C and m-AMSA for remission induction and consolidation treatment of patients with acute myeloid leukemia: an EORTC Leukemia Cooperative Group phase II study.
European journal of cancer & clinical oncology 1988;24(11):1721-5.
1988: Bob Löwenberg; Ivo P Touw
Hematopoietic growth factors and human acute leukemia.
Schweizerische medizinische Wochenschrift 1988;118(42):1506-9.
1988: Harry C Schouten; W Sizoo; M B van 't Veer; Anton Hagenbeek; Bob Löwenberg
Incomplete chimerism in erythroid, myeloid and B lymphocyte lineage after T cell-depleted allogeneic bone marrow transplantation.
Bone marrow transplantation 1988;3(5):407-12.
1988: Fredrik J Bot; L Dorssers; G Wagemaker; Bob Löwenberg
Stimulating spectrum of human recombinant multi-CSF (IL-3) on human marrow precursors: importance of accessory cells.
Blood 1988;71(6):1609-14.
1988: H J Adriaansen; Jacques J M van Dongen; Herbert Hooijkaas; Karel Hählen; M B van 't Veer; Bob Löwenberg; Anne Hagemeijer
Translocation (6;9) may be associated with a specific TdT-positive immunological phenotype in ANLL.
Leukemia 1988;2(3):136-40.
1988: M Salem; Ruud Delwel; Ivo P Touw; L Mahmoud; Bob Löwenberg
Human AML colony growth in serum-free culture.
Leukemia research 1988;12(2):157-65.
1988: Bob Löwenberg; M Salem; Ruud Delwel
Effects of recombinant multi-CSF, GM-CSF, G-CSF and M-CSF on the proliferation and maturation of human AML in vitro.
Blood cells 1988;14(2-3):539-49.
1987: W Sizoo; A Hagenbeek; Bob Löwenberg; M B van 't Veer; K Sintnicolaas
[Myelodysplastic syndromes].
Nederlands tijdschrift voor geneeskunde 1987;131(38):1658-61.
1987: Ruud Delwel; L Dorssers; I Touw; G Wagemaker; Bob Löwenberg
Human recombinant multilineage colony stimulating factor (interleukin-3): stimulator of acute myelocytic leukemia progenitor cells in vitro.
Blood 1987;70(1):333-6.
1987: I Touw; L Dorssers; Bob Löwenberg
The proliferative response of B cell chronic lymphocytic leukemia to interleukin 2: functional characterization of the interleukin 2 membrane receptors.
Blood 1987;69(6):1667-73.
1987: L Dorssers; H Burger; Fredrik J Bot; Ruud Delwel; A H Geurts van Kessel; Bob Löwenberg; G Wagemaker
Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3.
Gene 1987;55(1):115-24.
1987: Bob Löwenberg; J Abels; D W van Bekkum; W Sizoo; W D Hendriks; Mars B van't Veer; G Wagemaker; K Sintnicolaas; A Hagenbeek
Treatment of patients with acute myeloid leukemia in first remission with marrow ablative therapy and autologous bone marrow transplantation.
Haematology and blood transfusion 1987;30():233-6.
1986: Bob Löwenberg; G Wagemaker; D W van Bekkum; W Sizoo; K Sintnicolaas; W D Hendriks; Anton Hagenbeek
Graft-versus-host disease following transplantation of 'one log' versus 'two log' T-lymphocyte-depleted bone marrow from HLA-identical donors.
Bone marrow transplantation 1986;1(2):133-40.
1986: Bob Löwenberg; W Sizoo; G Wagemaker; K Sintnicolaas; W D Hendriks; A Hagenbeek
[Prevention of graft-versus-host disease following allogeneic bone marrow transplantation in patients with leukemia].
Nederlands tijdschrift voor geneeskunde 1986;130(19):872-6.
1985: A Hagenbeek; W D Hendriks; W Sizoo; K Sintnicolaas; Bob Löwenberg
[Successful bone marrow transplantation in a patient with non-Hodgkin lymphoma of high-grade malignancy with invasion of the central nervous system].
Nederlands tijdschrift voor geneeskunde 1985;129(15):698-700.
1984: Bob Löwenberg; J Abels; D W van Bekkum; G Dzoljic; A Hagenbeek; W D Hendriks; J van de Poel; W Sizoo; K Sintnicolaas; G Wagemaker
Transplantation of non-purified autologous bone marrow in patients with AML in first remission.
Cancer 1984;54(12):2840-3.
1984: W D Hendriks; W Sizoo; Bob Löwenberg; A Hagenbeek
[Bacteriologic management of patients with decreased resistance].
Nederlands tijdschrift voor geneeskunde 1984;128(7):305-10.
1983: Bob Löwenberg; J Abels; D W van Bekkum; G Dzoljic; W D Hendriks; J van der Poel; W Sizoo; K Sintnicolaas; G Wagemaker
[Transplantation of autologous bone marrow in 3 patients with acute myeloid leukemia in first remission; initial experiences with a new treatment].
Nederlands tijdschrift voor geneeskunde 1983;127(30):1329-32.