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Bob Löwenberg

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Sanz Miguel; Burnett Alan; Lo-Coco Francesco; Löwenberg Bob
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
Heuser Michael; Sly Laura M; Argiropoulos Bob; Kuchenbauer Florian; Lai Courteney; Weng Andrew; Leung Malina; Lin Grace; Brookes Christy; Fung Stephen; Valk Peter J; Delwel Ruud; Löwenberg Bob; Krystal Gerald; Humphries R Keith
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.
de Jonge Hendrik J M; de Bont Eveline S J M; Valk Peter J M; Schuringa Jan Jacob; Kies Marcel; Woolthuis Carolien M; Delwel Ruud; Veeger Nic J G M; Vellenga Edo; Löwenberg Bob; Huls Gerwin
AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.

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All Publications

2009: Sanz Miguel; Burnett Alan; Lo-Coco Francesco; Löwenberg Bob
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
Current opinion in oncology 2009;21(6):594-600.
2009: Heuser Michael; Sly Laura M; Argiropoulos Bob; Kuchenbauer Florian; Lai Courteney; Weng Andrew; Leung Malina; Lin Grace; Brookes Christy; Fung Stephen; Valk Peter J; Delwel Ruud; Löwenberg Bob; Krystal Gerald; Humphries R Keith
Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.
Blood 2009;114(19):3983-93.
2009: de Jonge Hendrik J M; de Bont Eveline S J M; Valk Peter J M; Schuringa Jan Jacob; Kies Marcel; Woolthuis Carolien M; Delwel Ruud; Veeger Nic J G M; Vellenga Edo; Löwenberg Bob; Huls Gerwin
AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.
Blood 2009;114(14):2869-77.
2009: Löwenberg Bob; Ossenkoppele Gert J; van Putten Wim; Schouten Harry C; Graux Carlos; Ferrant Augustin; Sonneveld Pieter; Maertens Johan; Jongen-Lavrencic Mojca; von Lilienfeld-Toal Marie; Biemond Bart J; Vellenga Edo; van Marwijk Kooy Marinus; Verdonck Leo F; Beck Joachim; Döhner Hartmut; Gratwohl Alois; Pabst Thomas; Verhoef Gregor;
High-dose daunorubicin in older patients with acute myeloid leukemia.
The New England journal of medicine 2009;361(13):1235-48.
2009: Bruinsma Marieke; van Soest Peter L; Leenen Pieter J M; Löwenberg Bob; Cornelissen Jan J; Braakman Eric
Keratinocyte growth factor improves allogeneic bone marrow engraftment through a CD4+Foxp3+ regulatory T cell-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7364-9.
2009: Wouters Bas J; Löwenberg Bob; Erpelinck-Verschueren Claudia A J; van Putten Wim L J; Valk Peter J M; Delwel Ruud
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.
Blood 2009;113(13):3088-91.
2009: Figueroa Maria E; Wouters Bas J; Skrabanek Lucy; Glass Jacob; Li Yushan; Erpelinck-Verschueren Claudia A J; Langerak Anton W; Löwenberg Bob; Fazzari Melissa; Greally John M; Valk Peter J M; Melnick Ari; Delwel Ruud
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.
Blood 2009;113(12):2795-804.
2009: Cornelissen Jan J; van der Holt Bronno; Verhoef Gregor E G; van't Veer Mars B; van Oers Marinus H J; Schouten Harry C; Ossenkoppele Gert; Sonneveld Pieter; Maertens Johan; van Marwijk Kooy Marinus; Schaafsma Martijn R; Wijermans Pierre W; Biesma Douwe H; Wittebol Shulamit; Voogt Paul J; Baars Joke W; Zachée Pierre; Verdonck Leo F; Löwenberg Bob; Dekker Adriaan W;
Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison.
Blood 2009;113(6):1375-82.
2009: Verhaak Roel G W; Wouters Bas J; Erpelinck Claudia A J; Abbas Saman; Beverloo H Berna; Lugthart Sanne; Löwenberg Bob; Delwel Ruud; Valk Peter J M
Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling.
Haematologica 2009;94(1):131-4.
2009: Wouters Bas J; Löwenberg Bob; Delwel Ruud
A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.
Blood 2009;113(2):291-8.
2008: Chamuleau Martine E D; van de Loosdrecht Arjan A; Hess Corine J; Janssen Jeroen J W M; Zevenbergen Adri; Delwel Ruud; Valk Peter J M; Löwenberg Bob; Ossenkoppele Gert J
High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome.
Haematologica 2008;93(12):1894-8.
2008: Abbas Saman; Rotmans Gabriëlle; Löwenberg Bob; Valk Peter J M
Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias.
Haematologica 2008;93(10):1595-7.
2008: Breems Dimitri A; Van Putten Wim L J; De Greef Georgine E; Van Zelderen-Bhola Shama L; Gerssen-Schoorl Klasien B J; Mellink Clemens H M; Nieuwint Aggie; Jotterand Martine; Hagemeijer Anne; Beverloo H Berna; Löwenberg Bob
Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(29):4791-7.
2008: Liso Arcangelo; Castiglione Filippo; Cappuccio Antonio; Stracci Fabrizio; Schlenk Richard F; Amadori Sergio; Thiede Christian; Schnittger Susanne; Valk Peter J M; Döhner Konstanze; Martelli Massimo F; Schaich Markus; Krauter Jürgen; Ganser Arnold; Martelli Maria P; Bolli Niccolò; Löwenberg Bob; Haferlach Torsten; Ehninger Gerhard; Mandelli Franco; Döhner Hartmut; Michor Franziska; Falini Brunangelo
A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1).
Haematologica 2008;93(8):1219-26.
2008: Gratama Jan W; Brooimans Rik A; van der Holt Bronno; Sintnicolaas Kees; van Doornum Gerard; Niesters Hubertus G; Löwenberg Bob; Cornelissen Jan J
Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations.
Cytometry. Part B, Clinical cytometry 2008;74(4):211-20.
2008: Löwenberg Bob
Diagnosis and prognosis in acute myeloid leukemia--the art of distinction.
The New England journal of medicine 2008;358(18):1960-2.
2008: Rijnders Bart J; Cornelissen Jan J; Slobbe Lennert; Becker Martin J; Doorduijn Jeanette K; Hop Wim C J; Ruijgrok Elisabeth J; Löwenberg Bob; Vulto Arnold; Lugtenburg Pieternella J; de Marie Siem
Aerosolized liposomal amphotericin B for the prevention of invasive pulmonary aspergillosis during prolonged neutropenia: a randomized, placebo-controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1401-8.
2008: Jongen-Lavrencic Mojca; Sun Su Ming; Dijkstra Menno K; Valk Peter J M; Löwenberg Bob
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia.
Blood 2008;111(10):5078-85.
2008: Lugthart Sanne; van Drunen Ellen; van Norden Yvette; van Hoven Antoinette; Erpelinck Claudia A J; Valk Peter J M; Beverloo H Berna; Löwenberg Bob; Delwel Ruud
High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.
Blood 2008;111(8):4329-37.
2008: Deenik Wendy; van der Holt Bronno; Verhoef Gregor E G; Smit Willem M; Kersten Marie J; Kluin-Nelemans Hanneke C; Verdonck Leo F; Ferrant Augustin; Schattenberg Anton V M B; Janssen Jeroen J W M; Sonneveld Pieter; van Marwijk Kooy Marinus; Wittebol Shulamit; Willemze Roelof; Wijermans Pierre W; Westveer Petra H M; Beverloo H Berna; Valk Peter; Löwenberg Bob; Ossenkoppele Gert J; Cornelissen Jan J
Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia.
Blood 2008;111(5):2581-8.
2008: Raponi Mitch; Lancet Jeffrey E; Fan Hongtao; Dossey Lesley; Lee Grace; Gojo Ivana; Feldman Eric J; Gotlib Jason; Morris Lawrence E; Greenberg Peter L; Wright John J; Harousseau Jean-Luc; Löwenberg Bob; Stone Richard M; De Porre Peter; Wang Yixin; Karp Judith E
A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia.
Blood 2008;111(5):2589-96.
2008: van Wageningen Sake; Breems-de Ridder Marleen C; Nigten Jeannet; Nikoloski Gorica; Erpelinck-Verschueren Claudia A J; Löwenberg Bob; de Witte Theo; Tenen Daniel G; van der Reijden Bert A; Jansen Joop H
Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha.
Blood 2008;111(3):1634-43.
2008: Sanders Mathijs A; Verhaak Roel G W; Geertsma-Kleinekoort Wendy M C; Abbas Saman; Horsman Sebastiaan; van der Spek Peter J; Löwenberg Bob; Valk Peter J M
SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels.
BMC genomics 2008;9():41.
2007: Bruinsma Marieke; van Soest Peter L; Leenen Pieter J M; Lambrecht Bart N; Cupedo Tom; Löwenberg Bob; Cornelissen Jan J; Braakman Eric
Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7424-30.
2007: Wouters Bas J; Jordà Meritxell Alberich; Keeshan Karen; Louwers Irene; Erpelinck-Verschueren Claudia A J; Tielemans Dennis; Langerak Anton W; He Yiping; Yashiro-Ohtani Yumi; Zhang Pu; Hetherington Christopher J; Verhaak Roel G W; Valk Peter J M; Löwenberg Bob; Tenen Daniel G; Pear Warren S; Delwel Ruud
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Blood 2007;110(10):3706-14.
2007: Wouters B J; Sanders M A; Lugthart S; Geertsma-Kleinekoort W M C; van Drunen E; Beverloo H B; Löwenberg B; Valk P J M; Delwel R
Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(11):2382-4.
2007: Breems Dimitri A; Löwenberg Bob
Acute myeloid leukemia and the position of autologous stem cell transplantation.
Seminars in hematology 2007;44(4):259-66.
2007: Broers Annoek E C; Bruinsma Marieke; Posthumus-van Sluijs Sandra J; Wils Evert-Jan; Spits Hergen; Löwenberg Bob; Braakman Eric; Cornelissen Jan J
IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells.
Haematologica 2007;92(8):1099-106.
2007: Rayman Nazik; Lam King H; Van Leeuwen Joost; Mulder Andries H; Budel Leo M; Löwenberg Bob; Sonneveld Pieter; Delwel Ruud
The expression of the peripheral cannabinoid receptor on cells of the immune system and non-Hodgkin's lymphomas.
Leukemia & lymphoma 2007;48(7):1389-99.
2007: van Hest Reinier M; Doorduijn Jeanette K; de Winter Brenda C M; Cornelissen Jan J; Vulto Arnold G; Oellerich Michael; Löwenberg Bob; Mathot Ron A A; Armstrong Victor William; van Gelder Teun
Pharmacokinetics of mycophenolate mofetil in hematopoietic stem cell transplant recipients.
Therapeutic drug monitoring 2007;29(3):353-60.
2007: Bakker Walbert J; van Dijk Thamar B; Parren-van Amelsvoort Martine; Kolbus Andrea; Yamamoto Kazuo; Steinlein Peter; Verhaak Roel G W; Mak Tak W; Beug Hartmut; Löwenberg Bob; von Lindern Marieke
Differential regulation of Foxo3a target genes in erythropoiesis.
Molecular and cellular biology 2007;27(10):3839-3854.
2007: van den Heuvel-Eibrink Marry M; van der Holt Bronno; Burnett Alan K; Knauf Wolfgang U; Fey Martin F; Verhoef Gregor E G; Vellenga Edo; Ossenkoppele Gert J; Löwenberg Bob; Sonneveld Pieter
CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age.
Annals of hematology 2007;86(5):329-37.
2007: Raponi Mitch; Harousseau Jean-Luc; Lancet Jeffrey E; Löwenberg Bob; Stone Richard; Zhang Yi; Rackoff Wayne; Wang Yixin; Atkins David
Identification of molecular predictors of response in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2254-60.
2007: Armand Jean-Pierre; Burnett Alan K; Drach Johannes; Harousseau Jean-Luc; Löwenberg Bob; San Miguel Jesús
The emerging role of targeted therapy for hematologic malignancies: update on bortezomib and tipifarnib.
The oncologist 2007;12(3):281-90.
2007: Schellings Mark W; Löwenberg Bob; Pinto Yigal M
Another look at imatinib mesylate.
The New England journal of medicine 2007;356(11):1183; author reply 1183.
2007: Wils Evert-Jan; Braakman Eric; Verjans Georges M G M; Rombouts Elwin J C; Broers Annoek E C; Niesters Hubert G M; Wagemaker Gerard; Staal Frank J T; Löwenberg Bob; Spits Hergen; Cornelissen Jan J
Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3551-7.
2007: Deenik W; van der Holt B; Verhoef G E G; Schattenberg A V M B; Verdonck L F; Daenen S M G J; Zachée P; Westveer P H M; Smit W M; Wittebol S; Schouten H C; Löwenberg B; Ossenkoppele G J; Cornelissen J J
High-vs low-dose cytarabine combined with interferon alfa in patients with first chronic phase chronic myeloid leukemia. A prospective randomized phase III study.
Annals of hematology 2007;86(2):117-25.
2007: Wouters Bas J; Louwers Irene; Valk Peter J M; Löwenberg Bob; Delwel Ruud
A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML.
Blood 2007;109(1):389-90.
2007: Löwenberg Bob
On the road to new drugs in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(1):1-2.
2007: van der Holt Bronno; Breems Dimitri A; Berna Beverloo H; van den Berg Eva; Burnett Alan K; Sonneveld Pieter; Löwenberg Bob
Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a prospective clinical trial.
British journal of haematology 2007;136(1):96-105.
2006: van der Holt Bronno; Van den Heuvel-Eibrink Marry M; Van Schaik Ron H N; van der Heiden Ilse P; Wiemer Erik A C; Vossebeld Paula J M; Löwenberg Bob; Sonneveld Pieter
ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients.
Clinical pharmacology and therapeutics 2006;80(5):427-39.
2006: Te Boekhorst P A W; Lamers C H J; Schipperus M R; Hintzen R Q; van der Holt B; Cornelissen J J; Löwenberg B; Gratama J W
T-lymphocyte reconstitution following rigorously T-cell-depleted versus unmodified autologous stem cell transplants.
Bone marrow transplantation 2006;37(8):763-72.
2006: Vos Margreet C; Endtz Hubert P; Horst-Kreft Deborah; Doorduijn Jeanette; Lugtenburg Elly; Verbrugh Henri A; Löwenberg Bob; de Marie Siem; van Pelt Cindy; van Belkum Alex
Candida krusei transmission among hematology patients resolved by adapted antifungal prophylaxis and infection control measures.
Journal of clinical microbiology 2006;44(3):1111-4.
2006: Erkeland Stefan J; Verhaak Roel G W; Valk Peter J M; Delwel Ruud; Löwenberg Bob; Touw Ivo P
Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia.
Cancer research 2006;66(2):622-6.
2006: Samijn J P A; te Boekhorst P A W; Mondria T; van Doorn P A; Flach H Z; van der Meché F G A; Cornelissen J; Hop W C; Löwenberg B; Hintzen R Q
Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2006;77(1):46-50.
2006: Verhaak Roel G W; Sanders Mathijs A; Bijl Maarten A; Delwel Ruud; Horsman Sebastiaan; Moorhouse Michael J; van der Spek Peter J; Löwenberg Bob; Valk Peter J M
HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics.
BMC bioinformatics 2006;7():337.
2005: Marteijn Jurgen A F; van Emst Liesbeth; Erpelinck-Verschueren Claudia A J; Nikoloski Gorica; Menke Aswin; de Witte Theo; Löwenberg Bob; Jansen Joop H; van der Reijden Bert A
The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.
Blood 2005;106(13):4114-23.
2005: Verhaak Roel G W; Goudswaard Chantal S; van Putten Wim; Bijl Maarten A; Sanders Mathijs A; Hugens Wendy; Uitterlinden André G; Erpelinck Claudia A J; Delwel Ruud; Löwenberg Bob; Valk Peter J M
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance.
Blood 2005;106(12):3747-54.
2005: Larson Richard A; Sievers Eric L; Stadtmauer Edward A; Löwenberg Bob; Estey Elihu H; Dombret Hervé; Theobald Matthias; Voliotis Dimitris; Bennett John M; Richie Maria; Leopold Lance H; Berger Mark S; Sherman Matthew L; Loken Michael R; van Dongen Jacques J M; Bernstein Irwin D; Appelbaum Frederick R
Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence.
Cancer 2005;104(7):1442-52.
2005: van der Holt Bronno; Löwenberg Bob; Burnett Alan K; Knauf Wolfgang U; Shepherd John; Piccaluga Pier Paolo; Ossenkoppele Gert J; Verhoef Gregor E G; Ferrant Augustin; Crump Michael; Selleslag Dominik; Theobald Matthias; Fey Martin F; Vellenga Edo; Dugan Margaret; Sonneveld Pieter
The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis.
Blood 2005;106(8):2646-54.
2005: Breems Dimitri A; Löwenberg Bob
Autologous stem cell transplantation in the treatment of adults with acute myeloid leukaemia.
British journal of haematology 2005;130(6):825-33.
2005: Kappers-Klunne M C; Wijermans P; Fijnheer R; Croockewit A J; van der Holt B; de Wolf J T M; Löwenberg B; Brand A
Splenectomy for the treatment of thrombotic thrombocytopenic purpura.
British journal of haematology 2005;130(5):768-76.
2005: Broers Annoek E C; van der Holt Bronno; Haze Sebastiaan; Braakman Eric; Gratama Jan-Willem; Löwenberg Bob; Cornelissen Jan J
A comparison of postengraftment infectious morbidity and mortality after allogeneic partially T cell-depleted peripheral blood progenitor cell transplantation versus T cell-depleted bone marrow transplantation.
Experimental hematology 2005;33(8):912-9.
2005: Barjesteh van Waalwijk van Doorn-Khosrovani Sahar; Spensberger Dominik; de Knegt Yvonne; Tang Michelle; Löwenberg Bob; Delwel Ruud
Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia.
Oncogene 2005;24(25):4129-37.
2005: van den Akker Eric; Vankan-Berkhoudt Yolanda; Valk Peter J M; Löwenberg Bob; Delwel Ruud
The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia.
Journal of virology 2005;79(9):5249-58.
2005: Nigten J; Breems-de Ridder M C; Erpelinck-Verschueren C A J; Nikoloski G; van der Reijden B A; van Wageningen S; van Hennik P B; de Witte T; Löwenberg B; Jansen J H
ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(5):799-805.
2005: Breems Dimitri A; Van Putten Wim L J; Huijgens Peter C; Ossenkoppele Gert J; Verhoef Gregor E G; Verdonck Leo F; Vellenga Edo; De Greef Georgine E; Jacky Emanuel; Van der Lelie Johannes; Boogaerts Marc A; Löwenberg Bob
Prognostic index for adult patients with acute myeloid leukemia in first relapse.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(9):1969-78.
2005: de Greef Georgine E; van Putten Wim L J; Boogaerts Marc; Huijgens Peter C; Verdonck Leo F; Vellenga Edo; Theobald Matthias; Jacky Emanuel; Löwenberg Bob;
Criteria for defining a complete remission in acute myeloid leukaemia revisited. An analysis of patients treated in HOVON-SAKK co-operative group studies.
British journal of haematology 2005;128(2):184-91.
2005: Breems Dimitri A; Boogaerts Marc A; Dekker Adriaan W; Van Putten Wim L J; Sonneveld Pieter; Huijgens Peter C; Van der Lelie Johannes; Vellenga Edo; Gratwohl Alois; Verhoef Gregor E G; Verdonck Leo F; Löwenberg Bob
Autologous bone marrow transplantation as consolidation therapy in the treatment of adult patients under 60 years with acute myeloid leukaemia in first complete remission: a prospective randomized Dutch-Belgian Haemato-Oncology Co-operative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK) trial.
British journal of haematology 2005;128(1):59-65.
2005: Valk Peter J M; Delwel Ruud; Löwenberg Bob
Gene expression profiling in acute myeloid leukemia.
Current opinion in hematology 2005;12(1):76-81.
2005: Cornelissen Jan J; Löwenberg Bob
Role of allogeneic stem cell transplantation in current treatment of acute myeloid leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005;():151-5.
2004: Daenen Simon; van der Holt Bronno; Verhoef Gregor E G; Löwenberg Bob; Wijermans Pierre W; Huijgens Peter C; van Marwijk Kooy Rien; Schouten Harry C; Kramer Mark H H; Ferrant Augustin; van den Berg Eva; Steijaert Monique M C; Verdonck Leo F; Sonneveld Pieter
Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia: a randomised phase II trial from HOVON, the Dutch-Belgian Haemato-Oncology Working Group for adults.
Leukemia research 2004;28(10):1057-67.
2004: Joosten Marieke; Blázquez-Domingo Montserrat; Lindeboom Fokke; Boulmé Florence; Van Hoven-Beijen Antoinette; Habermann Bianca; Löwenberg Bob; Beug Hartmut; Müllner Ernst W; Delwel Ruud; Von Lindern Marieke
Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling.
The Journal of biological chemistry 2004;279(37):38169-76.
2004: Rombouts Elwin J C; Pavic Biljana; Löwenberg Bob; Ploemacher Rob E
Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia.
Blood 2004;104(2):550-7.
2004: Alberich Jordà Meritxell; Rayman Nazik; Tas Marjolein; Verbakel Sandra E; Battista Natalia; van Lom Kirsten; Löwenberg Bob; Maccarrone Mauro; Delwel Ruud
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner.
Blood 2004;104(2):526-34.
2004: Mattern Karin A; Swiggers Susan J J; Nigg Alex L; Löwenberg Bob; Houtsmuller Adriaan B; Zijlmans J Mark J M
Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.
Molecular and cellular biology 2004;24(12):5587-94.
2004: van den Akker Emile; van Dijk Thamar; Parren-van Amelsvoort Martine; Grossmann Katja S; Schaeper Ute; Toney-Earley Kenya; Waltz Susan E; Löwenberg Bob; von Lindern Marieke
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.
Blood 2004;103(12):4457-65.
2004: van den Akker Emile; van Dijk Thamar B; Schmidt Uwe; Felida Lamberto; Beug Hartmut; Löwenberg Bob; von Lindern Marieke
The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity.
Biological chemistry 2004;385(5):409-13.
2004: Valk Peter J M; Verhaak Roel G W; Beijen M Antoinette; Erpelinck Claudia A J; Barjesteh van Waalwijk van Doorn-Khosrovani Sahar; Boer Judith M; Beverloo H Berna; Moorhouse Michael J; van der Spek Peter J; Löwenberg Bob; Delwel Ruud
Prognostically useful gene-expression profiles in acute myeloid leukemia.
The New England journal of medicine 2004;350(16):1617-28.
2004: Ossenkoppele Gert J; Graveland Wilfried J; Sonneveld Pieter; Daenen Simon M G J; Biesma Douwe H; Verdonck Leo F; Schaafsma M Ron; Westveer Petra H M; Peters Godefridus J; Noordhuis Paul; Muus Petra; Selleslag Dominik; van der Holt Bronnie; Delforge Michel; Löwenberg Bob; Verhoef Gregor E G;
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients.
Blood 2004;103(8):2908-13.
2004: Groot M T; van Agthoven M; Löwenberg B; Willemze R; Uyl-de Groot C A
[The role of cost analysis in the evaluation of the development of medical technology. The case of allogenic stem-cell transplantation]
Nederlands tijdschrift voor geneeskunde 2004;148(10):480-4.
2004: Schmidt Uwe; van den Akker Emile; Parren-van Amelsvoort Martine; Litos Gabi; de Bruijn Marella; Gutiérrez Laura; Hendriks Rudi W; Ellmeier Wilfried; Löwenberg Bob; Beug Hartmut; von Lindern Marieke
Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.
The Journal of experimental medicine 2004;199(6):785-95.
2004: Rayman Nazik; Lam King H; Laman Jon D; Simons Peter J; Löwenberg Bob; Sonneveld Pieter; Delwel Ruud
Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2111-7.
2004: Valk Peter J M; Bowen David T; Frew Marion E; Goodeve Anne C; Löwenberg Bob; Reilly John T
Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16).
Haematologica 2004;89(1):106.
2004: Bakker Walbert J; Blázquez-Domingo Montserrat; Kolbus Andrea; Besooyen Janey; Steinlein Peter; Beug Hartmut; Coffer Paul J; Löwenberg Bob; von Lindern Marieke; van Dijk Thamar B
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.
The Journal of cell biology 2004;164(2):175-84.
2004: Levin Mark-David; Kappers-Klunne Mies; Sintnicolaas Kees; van der Holt Bronno; van Vliet Huub H D M; Löwenberg Bob; van't Veer Mars B
The value of alloantibody detection in predicting response to HLA-matched platelet transfusions.
British journal of haematology 2004;124(2):244-50.
2003: Cheson Bruce D; Bennett John M; Kopecky Kenneth J; Büchner Thomas; Willman Cheryl L; Estey Elihu H; Schiffer Charles A; Doehner Hartmut; Tallman Martin S; Lister T Andrew; Lo-Coco Francesco; Willemze Roel; Biondi Andrea; Hiddemann Wolfgang; Larson Richard A; Löwenberg Bob; Sanz Miguel A; Head David R; Ohno Ryuzo; Bloomfield Clara D;
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(24):4642-9.
2003: Barjesteh van Waalwijk van Doorn-Khosrovani Sahar; Erpelinck Claudia; Löwenberg Bob; Delwel Ruud
Low expression of MDS1-EVI1-like-1 (MEL1) and EVI1-like-1 (EL1) genes in favorable-risk acute myeloid leukemia.
Experimental hematology 2003;31(11):1066-72.
2003: Meijer Ellen; Cornelissen Jan J; Löwenberg Bob; Verdonck Leo F
Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell-depleted grafts from matched unrelated donors: a dose-finding study.
Experimental hematology 2003;31(11):1026-30.
2003: Cornelissen Jan J; van der Holt Bronno; Petersen Eefke J; Vindelov Lars; Russel Charlotte A; Höglund Martin; Maertens Johan; Schouten Harry C; Braakman Eric; Steijaert Monique M C; Zijlmans Mark J M; Slaper-Cortenbach Ineke; Boogaerts Marc A; Löwenberg Bob; Verdonck Leo F
A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies.
Experimental hematology 2003;31(10):855-64.
2003: Löwenberg Bob
Minimal residual disease in chronic myeloid leukemia.
The New England journal of medicine 2003;349(15):1399-401.
2003: Commeren Dianne L; Van Soest Peter L; Karimi Khalil; Löwenberg Bob; Cornelissen Jan J; Braakman Eric
Paradoxical effects of interleukin-10 on the maturation of murine myeloid dendritic cells.
Immunology 2003;110(2):188-96.
2003: van Pelt Cindy; Nouwen Jan; Lugtenburg Elly; van der Schee Cindy; de Marie Simon; Schuijff Paula; Verbrugh Henri; Löwenberg Bob; van Belkum Alex; Vos Margreet
Strict infection control measures do not prevent clonal spread of coagulase negative staphylococci colonizing central venous catheters in neutropenic hemato-oncologic patients.
FEMS immunology and medical microbiology 2003;38(2):153-8.
2003: Löwenberg Bob; van Putten Wim; Theobald Matthias; Gmür Jurg; Verdonck Leo; Sonneveld Pieter; Fey Martin; Schouten Harry; de Greef Georgine; Ferrant Augustin; Kovacsovics Tibor; Gratwohl Alois; Daenen Simon; Huijgens Peter; Boogaerts Marc;
Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia.
The New England journal of medicine 2003;349(8):743-52.
2003: Broers Annoek E C; Posthumus-van Sluijs Sandra J; Spits Hergen; van der Holt Bronno; Löwenberg Bob; Braakman Eric; Cornelissen Jan J
Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants.
Blood 2003;102(4):1534-40.
2003: Care Rory S; Valk Peter J M; Goodeve Anne C; Abu-Duhier Faisel M; Geertsma-Kleinekoort Wendy M C; Wilson Giu A; Gari Mamdooh A; Peake Ian R; Löwenberg Bob; Reilly John T
Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.
British journal of haematology 2003;121(5):775-7.
2003: Barjesteh van Waalwijk van Doorn-Khosrovani Sahar; Erpelinck Claudia; van Putten Wim L J; Valk Peter J M; van der Poel-van de Luytgaarde Sonja; Hack Ronald; Slater Rosalyn; Smit Elisabeth M E; Beverloo H Berna; Verhoef Gregor; Verdonck Leo F; Ossenkoppele Gert J; Sonneveld Pieter; de Greef Georgine E; Löwenberg Bob; Delwel Ruud
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.
Blood 2003;101(3):837-45.
2003: Löwenberg Bob; Griffin James D; Tallman Martin S
Acute myeloid leukemia and acute promyelocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():82-101.
2003: Barjesteh van Waalwijk van Doorn-Khosrovani Sahar; Erpelinck Claudia; Meijer Joost; van Oosterhoud Susanna; van Putten Wim L J; Valk Peter J M; Berna Beverloo H; Tenen Daniel G; Löwenberg Bob; Delwel Ruud
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.
The hematology journal : the official journal of the European Haematology Association / EHA 2003;4(1):31-40.
2002: Joosten Marieke; Vankan-Berkhoudt Yolanda; Tas Marjolein; Lunghi Monja; Jenniskens Yvonne; Parganas Evan; Valk Peter J M; Löwenberg Bob; van den Akker Eric; Delwel Ruud
Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites.
Oncogene 2002;21(47):7247-55.
2002: van Agthoven M; Groot M T; Verdonck L F; Löwenberg B; Schattenberg A V M B; Oudshoorn M; Hagenbeek A; Cornelissen J J; Uyl-de Groot C A; Willemze R
Cost analysis of HLA-identical sibling and voluntary unrelated allogeneic bone marrow and peripheral blood stem cell transplantation in adults with acute myelocytic leukaemia or acute lymphoblastic leukaemia.
Bone marrow transplantation 2002;30(4):243-51.
2002: van der Reijden Bert A; Simons Annet; Luiten Erna; van der Poel Sonja C; Hogenbirk Pauline E; Tönnissen Evelyn; Valk Peter J M; Löwenberg Bob; De Greef Georgine E; Breuning Martijn H; Jansen Joop H
Minimal residual disease quantification in patients with acute myeloid leukaemia and inv(16)/CBFB-MYH11 gene fusion.
British journal of haematology 2002;118(2):411-8.
2002: Broers Annoek E C; Meijerink Jules P P; van Dongen Jacques J M; Posthumus Sandra J; Löwenberg Bob; Braakman Eric; Cornelissen Jan J
Quantification of newly developed T cells in mice by real-time quantitative PCR of T-cell receptor rearrangement excision circles.
Experimental hematology 2002;30(7):745-50.
2002: van Esser Joost W J; Niesters Hubert G M; van der Holt Bronno; Meijer Ellen; Osterhaus Albert D M E; Gratama Jan Willem; Verdonck Leo F; Löwenberg Bob; Cornelissen Jan J
Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation.
Blood 2002;99(12):4364-9.
2002: Jordà Meritxell Alberich; Verbakel Sandra E; Valk Peter J M; Vankan-Berkhoudt Yolanda V; Maccarrone Mauro; Finazzi-Agrò Allessandro; Löwenberg Bob; Delwel Ruud
Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol.
Blood 2002;99(8):2786-93.
2002: Joosten Marieke; Valk Peter J M; Jordà Meritxell Alberich; Vankan-Berkhoudt Yolanda; Verbakel Sandra; van den Broek Marion; Beijen Antoinette; Löwenberg Bob; Delwel Ruud
Leukemic predisposition of pSca-1/Cb2 transgenic mice.
Experimental hematology 2002;30(2):142-9.
2002: Oomen Sigrid P M A; van Hennik Paula B; Antonissen Claudia; Lichtenauer-Kaligis Elgin G R; Hofland Leo J; Lamberts Steven W J; Löwenberg Bob; Touw Ivo P
Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells.
Experimental hematology 2002;30(2):116-25.
2002: Somers J A E; Shamelian S O A; Löwenberg B; Ossenkoppele G J; Cornelissen J J
[STI571: a new dimension in the treatment of chronic myeloid leukemia]
Nederlands tijdschrift voor geneeskunde 2002;146(3):128-32.
2001: van Belkum A; Goessens W; van der Schee C; Lemmens-den Toom N; Vos M C; Cornelissen J; Lugtenburg E; de Marie S; Verbrugh H; Löwenberg B; Endtz H
Rapid emergence of ciprofloxacin-resistant enterobacteriaceae containing multiple gentamicin resistance-associated integrons in a Dutch hospital.
Emerging infectious diseases 2001;7(5):862-71.
2001: Gratama J W; van Esser J W; Lamers C H; Tournay C; Löwenberg B; Bolhuis R L; Cornelissen J J
Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection.
Blood 2001;98(5):1358-64.
2001: Oomen S P; Hofland L J; Lamberts S W; Löwenberg B; Touw I P
Internalization-defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells.
FEBS letters 2001;503(2-3):163-7.
2001: van Esser J W; van der Holt B; Meijer E; Niesters H G; Trenschel R; Thijsen S F; van Loon A M; Frassoni F; Bacigalupo A; Schaefer U W; Osterhaus A D; Gratama J W; Löwenberg B; Verdonck L F; Cornelissen J J
Epstein-Barr virus (EBV) reactivation is a frequent event after allogeneic stem cell transplantation (SCT) and quantitatively predicts EBV-lymphoproliferative disease following T-cell--depleted SCT.
Blood 2001;98(4):972-8.
2001: Löwenberg B
Managing therapy in older adult patients with acute myeloid leukemia.
Seminars in hematology 2001;38(3 Suppl 6):10-6.
2001: Rombouts W J; Löwenberg B; van Putten W L; Ploemacher R E
Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(7):1046-53.
2001: Sievers E L; Larson R A; Stadtmauer E A; Estey E; Löwenberg B; Dombret H; Karanes C; Theobald M; Bennett J M; Sherman M L; Berger M S; Eten C B; Loken M R; van Dongen J J; Bernstein I D; Appelbaum F R;
Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(13):3244-54.
2001: van Esser J W; Niesters H G; Thijsen S F; Meijer E; Osterhaus A D; Wolthers K C; Boucher C A; Gratama J W; Budel L M; van der Holt B; van Loon A M; Löwenberg B; Verdonck L F; Cornelissen J J
Molecular quantification of viral load in plasma allows for fast and accurate prediction of response to therapy of Epstein-Barr virus-associated lymphoproliferative disease after allogeneic stem cell transplantation.
British journal of haematology 2001;113(3):814-21.
2001: Oomen S P; Lichtenauer-Kaligis E G; Verplanke N; Hofland J; Lamberts S W; Löwenberg B; Touw I P
Somatostatin induces migration of acute myeloid leukemia cells via activation of somatostatin receptor subtype 2.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(4):621-7.
2001: Lugtenburg P J; Krenning E P; Valkema R; Oei H Y; Lamberts S W; Eijkemans M J; van Putten W L; Löwenberg B
Somatostatin receptor scintigraphy useful in stage I-II Hodgkin's disease: more extended disease identified.
British journal of haematology 2001;112(4):936-44.
2001: Lugtenburg P J; Löwenberg B; Valkema R; Oei H Y; Lamberts S W; Eijkemans M J; van Putten W L; Krenning E P
Somatostatin receptor scintigraphy in the initial staging of low-grade non-Hodgkin's lymphomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(2):222-9.
2001: Jansen J H; Löwenberg B
Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein.
Seminars in hematology 2001;38(1):37-41.
2001: Oomen S P; Ward A C; Hofland L J; Lamberts S W; Löwenberg B; Touw I P
Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(5):322-9.
2001: Van der Reijden B A; de Wit L; van der Poel S; Luiten E B; Lafage-Pochitaloff M; Dastugue N; Gabert J; Löwenberg B; Jansen J H
Identification of a novel CBFB-MYH11 transcript: implications for RT-PCR diagnosis.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(3):206-9.
2000: van Dijk T B; van Den Akker E; Amelsvoort M P; Mano H; Löwenberg B; von Lindern M
Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.
Blood 2000;96(10):3406-13.
2000: Louz D; van den Broek M; Verbakel S; Vankan Y; van Lom K; Joosten M; Meijer D; Löwenberg B; Delwel R
Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic mice.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(11):1876-84.
2000: von Lindern M; Parren-van Amelsvoort M; van Dijk T; Deiner E; van den Akker E; van Emst-de Vries S; Willems P; Beug H; Löwenberg B
Protein kinase C alpha controls erythropoietin receptor signaling.
The Journal of biological chemistry 2000;275(44):34719-27.
2000: de Vetten M P; Jansen J H; van der Reijden B A; Berger M S; Zijlmans J M; Löwenberg B
Molecular remission of Philadelphia/bcr-abl-positive acute myeloid leukaemia after treatment with anti-CD33 calicheamicin conjugate (gemtuzumab ozogamicin, CMA-676).
British journal of haematology 2000;111(1):277-9.
2000: Doorduijn J K; Spruit P; van Der Holt B; van't Veer M; Budel L; Löwenberg B; Sonneveld P
Etoposide, mitoxantrone and prednisone: a salvage regimen with low toxicity for refractory or relapsed non-Hodgkin's lymphoma.
Haematologica 2000;85(8):814-9.
2000: Breems-de Ridder M C; Löwenberg B; Jansen J H
Retinoic acid receptor fusion proteins: friend or foe.
Molecular and cellular endocrinology 2000;165(1-2):1-6.
2000: de Koning J P; Soede-Bobok A A; Ward A C; Schelen A M; Antonissen C; van Leeuwen D; Löwenberg B; Touw I P
STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1).
Oncogene 2000;19(29):3290-8.
2000: Broxterman H J; Sonneveld P; van Putten W J; Lankelma J; Eekman C A; Ossenkoppele G J; Pinedo H M; Löwenberg B; Schuurhuis G J
P-glycoprotein in primary acute myeloid leukemia and treatment outcome of idarubicin/cytosine arabinoside-based induction therapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(6):1018-24.
2000: Rombouts W J; Blokland I; Löwenberg B; Ploemacher R E
Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(4):675-83.
2000: Broers A E; van Der Holt R; van Esser J W; Gratama J W; Henzen-Logmans S; Kuenen-Boumeester V; Löwenberg B; Cornelissen J J
Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation.
Blood 2000;95(7):2240-5.
2000: Joosten M; Valk P J; Vankan Y; de Both N; Löwenberg B; Delwel R
Phenotyping of Evi1, Evi11/Cb2, and Evi12 transformed leukemias isolated from a novel panel of cas-Br-M murine leukemia virus-infected mice.
Virology 2000;268(2):308-18.
2000: Sonneveld P; Burnett A; Vossebeld P; Ben-Am M; Rosenkranz G; Pfister C; Verhoef G; Dekker A; Ossenkoppele G; Ferrant C; Yin L; Gratwohl A; Kovacsovics T; Vellenga E; Capdeville R; Löwenberg B
Dose-finding study of valspodar (PSC 833) with daunorubicin and cytarabine to reverse multidrug resistance in elderly patients with previously untreated acute myeloid leukemia.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(6):411-21.
2000: Valk P; Verbakel S; von Lindern M; Löwenberg B; Delwel R
Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(4):254-63.
2000: de Koning J P; Ward A C; Caldenhoven E; de Groot R P; Löwenberg B; Touw I P
STAT3beta does not interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiation.
The hematology journal : the official journal of the European Haematology Association / EHA 2000;1(4):220-5.
1999: Löwenberg B; Downing J R; Burnett A
Acute myeloid leukemia.
The New England journal of medicine 1999;341(14):1051-62.
1999: Ossenkoppele G J; van der Holt B; Verhoef G E; Daenen S M; Verdonck L F; Sonneveld P; Wijermans P W; van der Lelie J; van Putten W L; Löwenberg B
A randomized study of granulocyte colony-stimulating factor applied during and after chemotherapy in patients with poor risk myelodysplastic syndromes: a report from the HOVON Cooperative Group. Dutch-Belgian Hemato-Oncology Cooperative Group.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(8):1207-13.
1999: van Lom K; Houtsmuller A B; van Putten W L; Slater R M; Löwenberg B
Cytogenetic clonality analysis of megakaryocytes in myelodysplastic syndrome by dual-color fluorescence in situ hybridization and confocal laser scanning microscopy.
Genes, chromosomes & cancer 1999;25(4):332-8.
1999: de Ridder M C; van der Plas A J; Erpelinck-Verschueren C A; Löwenberg B; Jansen J H
Dexamethasone does not counteract the response of acute promyelocytic leukaemia cells to all-trans retinoic acid.
British journal of haematology 1999;106(1):107-10.
1999: van der Reijden B A; Erpelinck-Verschueren C A; Löwenberg B; Jansen J H
TRIADs: a new class of proteins with a novel cysteine-rich signature.
Protein science : a publication of the Protein Society 1999;8(7):1557-61.
1999: von Lindern M; Zauner W; Mellitzer G; Steinlein P; Fritsch G; Huber K; Löwenberg B; Beug H
The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro.
Blood 1999;94(2):550-9.
1999: Jansen J H; de Ridder M C; Geertsma W M; Erpelinck C A; van Lom K; Smit E M; Slater R; vd Reijden B A; de Greef G E; Sonneveld P; Löwenberg B
Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor.
Blood 1999;94(1):39-45.
1999: Vellenga E; van Putten W L; Boogaerts M A; Daenen S M; Verhoef G E; Hagenbeek A; Jonkhoff A R; Huijgens P C; Verdonck L F; van der Lelie J; Schouten H C; Gmür J; Wijermans P; Gratwohl A; Hess U; Fey M F; Löwenberg B
Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?
Bone marrow transplantation 1999;23(12):1279-82.
1999: Valk P J; Vankan Y; Joosten M; Jenkins N A; Copeland N G; Löwenberg B; Delwel R
Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.
Journal of virology 1999;73(5):3595-602.
1999: Segeren C M; Sonneveld P; van der Holt B; Baars J W; Biesma D H; Cornellissen J J; Croockewit A J; Dekker A W; Fibbe W E; Löwenberg B; van Marwijk Kooy M; van Oers M H; Richel D J; Schouten H C; Vellenga E; Verhoef G E; Wijermans P W; Wittebol S; Lokhorst H M
Vincristine, doxorubicin and dexamethasone (VAD) administered as rapid intravenous infusion for first-line treatment in untreated multiple myeloma.
British journal of haematology 1999;105(1):127-30.
1999: Broxterman H J; Sonneveld P; Pieters R; Lankelma J; Eekman C A; Loonen A H; Schoester M; Ossenkoppele G J; Löwenberg B; Pinedo H M; Schuurhuis G J
Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia?
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(2):258-65.
1998: Rozemuller H; Terpstra W; Rombouts E J; Lawler M; Byrne C; FitzGerald D J; Kreitman R J; Wielenga J J; Löwenberg B; Touw I P; Hagenbeek A; Martens A C
GM-CSF receptor targeted treatment of primary AML in SCID mice using Diphtheria toxin fused to huGM-CSF.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(12):1962-70.
1998: Hermans M H; Ward A C; Antonissen C; Karis A; Löwenberg B; Touw I P
Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia.
Blood 1998;92(1):32-9.
1998: Cornelissen J J; Fibbe W E; Schattenberg A V; Petersen E J; Willemze R; de Witte T J; Löwenberg B; Verdonck L F; vd Biezen A; Brand R
A retrospective Dutch study comparing T cell-depleted allogeneic blood stem cell transplantation vs T cell-depleted allogeneic bone marrow transplantation.
Bone marrow transplantation 1998;21 Suppl 3():S66-70.
1998: Sonneveld P; Laméris J S; Cornelissen J; Ogilvie A; Löwenberg B
Color-flow imaging sonography of portal and hepatic vein flow to monitor fibrinolytic therapy with r-TPA for veno-occlusive disease following myeloablative treatment.
Bone marrow transplantation 1998;21(7):731-4.
1998: Uyl-de Groot C A; Löwenberg B; Vellenga E; Suciu S; Willemze R; Rutten F F
Cost-effectiveness and quality-of-life assessment of GM-CSF as an adjunct to intensive remission induction chemotherapy in elderly patients with acute myeloid leukemia.
British journal of haematology 1998;100(4):629-36.
1998: Löwenberg B; Suciu S; Archimbaud E; Haak H; Stryckmans P; de Cataldo R; Dekker A W; Berneman Z N; Thyss A; van der Lelie J; Sonneveld P; Visani G; Fillet G; Hayat M; Hagemeijer A; Solbu G; Zittoun R
Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy--the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(3):872-81.
1998: Löwenberg B; Terpstra W
Maturation hierarchy of leukemic stem cells.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():85-8; discussion 89.
1997: Löwenberg B; Boogaerts M A; Daenen S M; Verhoef G E; Hagenbeek A; Vellenga E; Ossenkoppele G J; Huijgens P C; Verdonck L F; van der Lelie J; Wielenga J J; Schouten H C; Gmür J; Gratwohl A; Hess U; Fey M F; van Putten W L
Value of different modalities of granulocyte-macrophage colony-stimulating factor applied during or after induction therapy of acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(12):3496-506.
1997: Terpstra W; Rozemuller H; Breems D A; Rombouts E J; Prins A; FitzGerald D J; Kreitman R J; Wielenga J J; Ploemacher R E; Löwenberg B; Hagenbeek A; Martens A C
Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells.
Blood 1997;90(9):3735-42.
1997: Valk P J; Joosten M; Vankan Y; Löwenberg B; Delwel R
A rapid RT-PCR based method to isolate complementary DNA fragments flanking retrovirus integration sites.
Nucleic acids research 1997;25(21):4419-21.
1997: Löwenberg B; Suciu S; Archimbaud E; Ossenkoppele G; Verhoef G E; Vellenga E; Wijermans P; Berneman Z; Dekker A W; Stryckmans P; Schouten H; Jehn U; Muus P; Sonneveld P; Dardenne M; Zittoun R
Use of recombinant GM-CSF during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia: final report of AML-11, a phase III randomized study of the Leukemia Cooperative Group of European Organisation for the Research and Treatment of Cancer and the Dutch Belgian Hemato-Oncology Cooperative Group.
Blood 1997;90(8):2952-61.
1997: van den Heuvel-Eibrink M M; van der Holt B; te Boekhorst P A; Pieters R; Schoester M; Löwenberg B; Sonneveld P
MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia.
British journal of haematology 1997;99(1):76-83.
1997: Valk P J; Hol S; Vankan Y; Ihle J N; Askew D; Jenkins N A; Gilbert D J; Copeland N G; de Both N J; Löwenberg B; Delwel R
The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.
Journal of virology 1997;71(9):6796-804.
1997: Liem G S; Cornelissen J J; Oudshoorn M; Sintnicolaas K; Löwenberg B; Hagenbeek A
[Allogeneic bone marrow transplantation of unrelated donors; fewer complication, more donors]
Nederlands tijdschrift voor geneeskunde 1997;141(32):1553-6.
1997: Valk P; Verbakel S; Vankan Y; Hol S; Mancham S; Ploemacher R; Mayen A; Löwenberg B; Delwel R
Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells.
Blood 1997;90(4):1448-57.
1997: Terpstra W; Leenen P J; van den Bos C; Prins A; Loenen W A; Verstegen M M; van Wyngaardt S; van Rooijen N; Wognum A W; Wagemaker G; Wielenga J J; Löwenberg B
Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(7):1049-54.
1997: Terpstra W; Löwenberg B
Application of myeloid growth factors in the treatment of acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(3):315-27.
1997: Hoefsloot L H; van Amelsvoort M P; Broeders L C; van der Plas D C; van Lom K; Hoogerbrugge H; Touw I P; Löwenberg B
Erythropoietin-induced activation of STAT5 is impaired in the myelodysplastic syndrome.
Blood 1997;89(5):1690-700.
1997: Dekker A W; van't Veer M B; Sizoo W; Haak H L; van der Lelie J; Ossenkoppele G; Huijgens P C; Schouten H C; Sonneveld P; Willemze R; Verdonck L F; van Putten W L; Löwenberg B
Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Dutch Hemato-Oncology Research Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(2):476-82.
1997: van Lom K; Hagemeijer A; Vandekerckhove F; de Greef G E; Sacchi N; Löwenberg B
Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(2):202-5.
1997: Cornelissen J J; Wognum A W; Ploemacher R E; Frassoni F; Wagemaker G; Hagemeijer A; Löwenberg B
Efficient long-term maintenance of chronic myeloid leukemic cobblestone area forming cells on a murine stromal cell line.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(1):126-33.
1997: Dong F; Dale D C; Bonilla M A; Freedman M; Fasth A; Neijens H J; Palmblad J; Briars G L; Carlsson G; Veerman A J; Welte K; Löwenberg B; Touw I P
Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(1):120-5.
1997: Löwenberg B; van Putten W L; Ferrant A; Ossenkoppele G; Vellenga E; Verdonck L F; Gratwohl A; Boogaerts M A
Peripheral blood progenitor cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia.
Stem cells (Dayton, Ohio) 1997;15 Suppl 1():177-80; discussion 181.
1996: Doorduijn J K; van Lom K; Löwenberg B
Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years.
British journal of haematology 1996;95(3):531-4.
1996: Sonneveld P; Marie J P; Huisman C; Vekhoff A; Schoester M; Faussat A M; van Kapel J; Groenewegen A; Charnick S; Zittoun R; Löwenberg B
Reversal of multidrug resistance by SDZ PSC 833, combined with VAD (vincristine, doxorubicin, dexamethasone) in refractory multiple myeloma. A phase I study.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(11):1741-50.
1996: Terpstra W; Ploemacher R E; Prins A; van Lom K; Pouwels K; Wognum A W; Wagemaker G; Löwenberg B; Wielenga J J
Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture.
Blood 1996;88(6):1944-50.
1996: van den Anker-Lugtenburg P J; Löwenberg B; Lamberts S W; Krenning E P
The relevance of somatostatin receptor expression in malignant lymphomas.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):96-7.
1996: van der Plas D C; Smiers F; Pouwels K; Hoefsloot L H; Löwenberg B; Touw I P
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(8):1317-25.
1996: Fruehauf S; Breems D A; Knaän-Shanzer S; Brouwer K B; Haas R; Löwenberg B; Nooter K; Ploemacher R E; Valerio D; Boesen J J
Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123.
Human gene therapy 1996;7(10):1219-31.
1996: van Lom K; Hagemeijer A; Vandekerckhove F; Smit E M; Löwenberg B
Cytogenetic clonality analysis: typical patterns in myelodysplastic syndrome and acute myeloid leukaemia.
British journal of haematology 1996;93(3):594-600.
1996: van den Anker-Lugtenburg P J; Heule F; Vanhagen P M; van Joost T; Oei H Y; Löwenberg B; Krenning E P
Somatostatin receptor scintigraphy in cutaneous malignant lymphomas.
Journal of the American Academy of Dermatology 1996;34(6):985-93.
1996: Broxterman H J; Sonneveld P; Feller N; Ossenkoppele G J; Währer D C; Eekman C A; Schoester M; Lankelma J; Pinedo H M; Löwenberg B; Schuurhuis G J
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity.
Blood 1996;87(11):4809-16.
1996: van den Anker-Lugtenburg P J; Krenning E P; Oei H Y; Van Hagen M P; Gerrits C J; Reubi J C; Lamberts S W; Löwenberg B
Somatostatin receptor scintigraphy in the initial staging of Hodgkin's disease.
British journal of haematology 1996;93(1):96-103.
1996: Smiers F J; van Paassen M; Hählen K; Löwenberg B; Touw I P
CD20 and CD40 mediated mitogenic responses in B-lineage acute lymphoblastic leukaemia.
British journal of haematology 1996;93(1):125-30.
1996: Löwenberg B
Treatment of the elderly patient with acute myeloid leukaemia.
Baillière's clinical haematology 1996;9(1):147-59.
1996: Backx B; Broeders L; Hoefsloot L H; Wognum B; Löwenberg B
Erythropoiesis in myelodysplastic syndrome: expression of receptors for erythropoietin and kit ligand.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(3):466-72.
1996: Terpstra W; Prins A; Ploemacher R E; Wognum B W; Wagemaker G; Löwenberg B; Wielenga J J
Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia.
Blood 1996;87(6):2187-94.
1996: Barge R M; de Koning J P; Pouwels K; Dong F; Löwenberg B; Touw I P
Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route.
Blood 1996;87(6):2148-53.
1996: Dong F; Pouwels K; Hoefsloot L H; Rozemuller H; Löwenberg B; Touw I P
The C-terminal cytoplasmic region of the granulocyte colony-stimulating factor receptor mediates apoptosis in maturation-incompetent murine myeloid cells.
Experimental hematology 1996;24(2):214-20.
1996: Vellenga E; Uyl-de Groot C A; de Wit R; Keizer H J; Löwenberg B; ten Haaft M A; de Witte T J; Verhagen C A; Stoter G J; Rutten F F; Mulder N H; Smid W M; de Vries E G
Randomized placebo-controlled trial of granulocyte-macrophage colony-stimulating factor in patients with chemotherapy-related febrile neutropenia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(2):619-27.
1996: de Koning J P; Dong F; Smith L; Schelen A M; Barge R M; van der Plas D C; Hoefsloot L H; Löwenberg B; Touw I P
The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation.
Blood 1996;87(4):1335-42.
1996: Wielenga J J; Vellenga E; Groenewegen A; Sonneveld P; Löwenberg B
Recombinant human interleukin-3 (rH IL-3) in combination with remission induction chemotherapy in patients with relapsed acute myelogenous leukemia (AML): a phase I/II study.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(1):43-7.
1996: de Koning J P; Schelen A M; Dong F; van Buitenen C; Burgering B M; Bos J L; Löwenberg B; Touw I P
Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes.
Blood 1996;87(1):132-40.
1995: Fruehauf S; Boesen J J; Breems D A; Höft R; Hundsdörfer P; Zeller W J; Löwenberg B; Ploemacher R E; Haas R; Valerio D
Retroviral transfer of the multidrug resistance-1 gene into lineage-committed and primitive hemopoietic cells.
Stem cells (Dayton, Ohio) 1995;13 Suppl 3():93-9.
1995: van Lom K; Hagemeijer A; Smit E; Hählen K; Groeneveld K; Löwenberg B
Cytogenetic clonality analysis in myelodysplastic syndrome: monosomy 7 can be demonstrated in the myeloid and in the lymphoid lineage.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(11):1818-21.
1995: Uyl-de Groot C A; Hagenbeek A; Verdonck L F; Löwenberg B; Rutten F F
Cost-effectiveness of ABMT in comparison with CHOP chemotherapy in patients with intermediate- and high-grade malignant non-Hodgkin's lymphoma (NHL).
Bone marrow transplantation 1995;16(3):463-70.
1995: Terpstra W; Prins A; Visser T; Wognum B; Wagemaker G; Löwenberg B; Wielenga J
Conditions for engraftment of human acute myeloid leukemia (AML) in SCID mice.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(9):1573-7.
1995: Dong F; Brynes R K; Tidow N; Welte K; Löwenberg B; Touw I P
Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia.
The New England journal of medicine 1995;333(8):487-93.
1995: Smiers F J; van Paassen M; Pouwels K; Beishuizen A; Hählen K; Löwenberg B; Touw I P
Heterogeneity of proliferative responses of human B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells to interleukin 7 (IL-7): no correlation with immunoglobulin gene status and expression of IL-7 receptor or IL-2/IL-4/IL-7 receptor common gamma chain genes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(6):1039-45.
1995: te Boekhorst P A; Löwenberg B; van Kapel J; Nooter K; Sonneveld P
Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(6):1025-31.
1995: Budel L M; Dong F; Löwenberg B; Touw I P
Hematopoietic growth factor receptors: structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(4):553-61.
1995: Uyl-de Groot C A; Okhuijsen S Y; Hagenbeek A; Huijgens P C; van Imhoff G W; Löwenberg B; Verdonck L F; Rutten F F
Costs of introducing autologous BMT in the treatment of lymphoma and acute leukaemia in The Netherlands.
Bone marrow transplantation 1995;15(4):605-10.
1995: Dong F; van Paassen M; van Buitenen C; Hoefsloot L H; Löwenberg B; Touw I P
A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform.
Blood 1995;85(4):902-11.
1994: Gerrits C J; van Overhagen H; van Lom K; Adriaansen H J; Löwenberg B
Ultrasound examination of pathological cervical lymph nodes in patients with non-Hodgkin's lymphoma and Hodgkin's disease.
British journal of haematology 1994;88(3):626-8.
1994: Vlasveld L T; Splinter T A; Hagemeijer A; Van Lom K; Löwenberg B
Acute myeloid leukaemia with +i(12p) shortly after treatment of mediastinal germ cell tumour.
British journal of haematology 1994;88(1):196-8.
1994: te Boekhorst P A; Löwenberg B; Sonneveld P
Hematopoietic growth factor stimulation and cytarabine cytotoxicity in vitro: effects in untreated and relapsed or primary refractory acute myeloid leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(9):1480-6.
1994: Dong F; Hoefsloot L H; Schelen A M; Broeders C A; Meijer Y; Veerman A J; Touw I P; Löwenberg B
Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4480-4.
1994: van Gils F C; Budel L M; Burger H; van Leen R W; Löwenberg B; Wagemaker G
Interleukin-3 (IL-3) receptors on rhesus monkey bone marrow cells: species specificity of human IL-3, binding characteristics, and lack of competition with GM-CSF.
Experimental hematology 1994;22(3):248-55.
1994: van Hagen P M; Krenning E P; Kwekkeboom D J; Reubi J C; Anker-Lugtenburg P J; Löwenberg B; Lamberts S W
Somatostatin and the immune and haematopoetic system; a review.
European journal of clinical investigation 1994;24(2):91-9.
1993: Dong F; van Buitenen C; Pouwels K; Hoefsloot L H; Löwenberg B; Touw I P
Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.
Molecular and cellular biology 1993;13(12):7774-81.
1993: te Boekhorst P A; de Leeuw K; Schoester M; Wittebol S; Nooter K; Hagemeijer A; Löwenberg B; Sonneveld P
Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells.
Blood 1993;82(10):3157-62.
1993: te Boekhorst P A; Löwenberg B; Sonneveld P
Enhanced chemosensitivity in acute myeloid leukemia by hematopoietic growth factors: a comparison of the MTT assay with a clonogenic assay.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(10):1637-44.
1993: van Lom K; Hagemeijer A; Smit E M; Löwenberg B
In situ hybridization on May-Grünwald Giemsa-stained bone marrow and blood smears of patients with hematologic disorders allows detection of cell-lineage-specific cytogenetic abnormalities.
Blood 1993;82(3):884-8.
1993: te Boekhorst P A; Löwenberg B; Vlastuin M; Sonneveld P
Enhanced chemosensitivity of clonogenic blasts from patients with acute myeloid leukemia by G-CSF, IL-3 or GM-CSF stimulation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(8):1191-8.
1993: van't Veer M B; van Putten W L; Verdonck L F; Ossenkoppele G J; Löwenberg B; Kluin-Nelemans J C; Wijermans P W; Schouten H C; Sizoo W; Dekker A W
Acute lymphoblastic leukaemia in adults: immunological subtypes and clinical features at presentation.
Annals of hematology 1993;66(6):277-82.
1993: Budel L M; Hoogerbrugge H; Pouwels K; van Buitenen C; Delwel R; Löwenberg B; Touw I P
Granulocyte-macrophage colony-stimulating factor receptors alter their binding characteristics during myeloid maturation through up-regulation of the affinity converting beta subunit (KH97).
The Journal of biological chemistry 1993;268(14):10154-9.
1993: Löwenberg B; van Putten W L; Touw I P; Delwel R; Santini V
Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia.
The New England journal of medicine 1993;328(9):614-9.
1993: Budel L M; Delwel R; van Buitenen C; Hoogerbrugge H; Löwenberg B
Effects of mast cell growth factor on acute myeloid leukemia cells in vitro: effects of combinations with other cytokines.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(3):426-34.
1993: Löwenberg B; Touw I P
Hematopoietic growth factors and their receptors in acute leukemia.
Blood 1993;81(2):281-92.
1993: Backx B; Broeders L; Touw I; Löwenberg B
Blast colony-forming cells in myelodysplastic syndrome: decreased potential to generate erythroid precursors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(1):75-9.
1993: Vanhagen P M; Krenning E P; Reubi J C; Mulder A H; Bakker W H; Oei H Y; Löwenberg B; Lamberts S W
Somatostatin analogue scintigraphy of malignant lymphomas.
British journal of haematology 1993;83(1):75-9.
1993: Löwenberg B
Leukemia and myelodysplasia.
Cancer chemotherapy and biological response modifiers 1993;14():371-82.
1992: Creemers G J; Löwenberg B; Hagenbeek A
Allogeneic bone marrow transplantation for primary myelofibrosis.
British journal of haematology 1992;82(4):772-3.
1992: Delwel R; van Buitenen C; Löwenberg B; Touw I
Involvement of tumor necrosis factor (TNF) receptors p55 and p75 in TNF responses of acute myeloid leukemia blasts in vitro.
Blood 1992;80(7):1798-803.
1992: Backx B; Broeders L; Löwenberg B
Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome.
Blood 1992;80(5):1213-7.
1992: Elbaz O; Mahmoud L A; Touw I P; Löwenberg B
Analysis of the TNF receptors on human leukaemia cells by affinity cross-linking.
British journal of haematology 1992;81(4):530-2.
1992: Touw I; van Gurp R; Schipper P; van Agthoven T; Löwenberg B
Introduction of the human interleukin-6 (IL-6) receptor in murine IL-3-dependent hematopoietic cells restores responsiveness to IL-6.
Blood 1992;79(11):2867-72.
1991: Colombat P; Santini V; Delwel R; Krefft J; Bredmond J L; Löwenberg B
Primary human acute myeloblastic leukaemia: an analysis of in vitro granulocytic maturation following stimulation with retinoic acid and G-CSF.
British journal of haematology 1991;79(3):382-9.
1991: Touw I; Donath J; Pouwels K; van Buitenen C; Schipper P; Santini V; Hagemeijer A; Löwenberg B; Delwel R
Acute myeloid leukemias with chromosomal abnormalities involving the 21q22 region identified by their in vitro responsiveness to interleukin-5.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(8):687-92.
1991: Elbaz O; Budel L M; Hoogerbrugge H; Touw I P; Delwel R; Mahmoud L A; Löwenberg B
Tumor necrosis factor regulates the expression of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells.
Blood 1991;77(5):989-95.
1991: Elbaz O; Budel L M; Hoogerbrugge H; Touw I P; Delwel R; Mahmoud L A; Löwenberg B
Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.
The Journal of clinical investigation 1991;87(3):838-41.
1991: Backx B; Broeders L; Bot F J; Löwenberg B
Positive and negative effects of tumor necrosis factor on colony growth from highly purified normal marrow progenitors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(1):66-70.
1991: Santini V; Colombat P; Delwel R; van Gurp R; Touw I; Löwenberg B
Induction of granulocytic maturation in acute myeloid leukemia by G-CSF and retinoic acid.
Leukemia research 1991;15(5):341-50.
1990: Ruit J B; Löwenberg B; Hagenbeek A; Verhoef G E; Wielenga J J; Michiels J; Sizoo W
Phase II study of lomustine, cytarabine, mitoxantrone, and prednisone (CAMP) combination chemotherapy for doxorubicin-resistant intermediate- and high-grade malignant non-Hodgkin's lymphoma.
Seminars in oncology 1990;17(6 Suppl 10):24-7.
1990: Delwel R; van Buitenen C; Salem M; Oosterom R; Touw I; Löwenberg B
Hemopoietin-1 activity of interleukin-1 (IL-1) on acute myeloid leukemia colony-forming cells (AML-CFU) in vitro: IL-1 induces production of tumor necrosis factor-alpha which synergizes with IL-3 or granulocyte-macrophage colony-stimulating factor.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(8):557-60.
1990: Touw I P; Pouwels K; van Agthoven A J; van Gurp R; Delwel R; Hagemeijer A; Hählen K; Löwenberg B
Role of interleukin-7 in the growth of acute lymphoblastic leukemia.
Bone marrow transplantation 1990;6 Suppl 1():36-8.
1990: Delwel R; Schipper P; van Buitenen C; van Agthoven T; Touw I; Löwenberg B
Comparative analysis of IL-1 regulated and spontaneous growth of acute myeloid leukemia in vitro.
Bone marrow transplantation 1990;6 Suppl 1():22-6.
1990: Bot F J; Schipper P; Broeders L; Delwel R; Kaushansky K; Löwenberg B
Interleukin-1 alpha also induces granulocyte-macrophage colony-stimulating factor in immature normal bone marrow cells.
Blood 1990;76(2):307-11.
1990: Touw I; Pouwels K; van Agthoven T; van Gurp R; Budel L; Hoogerbrugge H; Delwel R; Goodwin R; Namen A; Löwenberg B
Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia.
Blood 1990;75(11):2097-101.
1990: Bot F J; van Eijk L; Schipper P; Backx B; Löwenberg B
Synergistic effects between GM-CSF and G-CSF or M-CSF on highly enriched human marrow progenitor cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(5):325-8.
1990: Budel L M; Elbaz O; Hoogerbrugge H; Delwel R; Mahmoud L A; Löwenberg B; Touw I P
Common binding structure for granulocyte macrophage colony-stimulating factor and interleukin-3 on human acute myeloid leukemia cells and monocytes.
Blood 1990;75(7):1439-45.
1990: Löwenberg B; Verdonck L J; Dekker A W; Willemze R; Zwaan F E; de Planque M; Abels J; Sonneveld P; van der Lelie J; Goudsmit R
Autologous bone marrow transplantation in acute myeloid leukemia in first remission: results of a Dutch prospective study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(2):287-94.
1990: Salem M; Delwel R; Touw I; Mahmoud L A; Elbasousy E M; Löwenberg B
Modulation of colony stimulating factor-(CSF) dependent growth of acute myeloid leukemia by tumor necrosis factor.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(1):37-43.
1990: Santini V; Nooter K; Delwel R; Löwenberg B
Susceptibility of acute myeloid leukemia (AML) cells from clinically resistant and sensitive patients to daunomycin (DNR): assessment in vitro after stimulation with colony stimulating factors (CSFs).
Leukemia research 1990;14(4):377-80.
1990: Löwenberg B; Delwel R; Touw I
Hematopoietic growth factors and progenitor cells in human acute leukemia.
Immunology series 1990;49():277-96.
1990: Jehn U; Zittoun R; Suciu S; Fiere D; Haanen C; Peetermans M; Löwenberg B; Willemze R; Solbu G; Stryckmans P
A randomized comparison of intensive maintenance treatment for adult acute myelogenous leukemia using either cyclic alternating drugs or repeated courses of the induction-type chemotherapy: AML-6 trial of the EORTC Leukemia Cooperative Group.
Haematology and blood transfusion 1990;33():277-84.
1989: Budel L M; Touw I P; Delwel R; Löwenberg B
Granulocyte colony-stimulating factor receptors in human acute myelocytic leukemia.
Blood 1989;74(8):2668-73.
1989: Löwenberg B; Zittoun R; Kerkhofs H; Jehn U; Abels J; Debusscher L; Cauchie C; Peetermans M; Solbu G; Suciu S
On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(9):1268-74.
1989: Delwel R; van Buitenen C; Salem M; Bot F; Gillis S; Kaushansky K; Altrock B; Löwenberg B
Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release.
Blood 1989;74(2):586-93.
1989: Budel L M; Touw I P; Delwel R; Clark S C; Löwenberg B
Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response.
Blood 1989;74(2):565-71.
1989: Touw I; Groot-Loonen J; Broeders L; van Agthoven T; Hählen K; Hagemeijer A; Löwenberg B
Recombinant hematopoietic growth factors fail to induce a proliferative response in precursor B acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1989;3(5):356-62.
1989: Bot F J; van Eijk L; Schipper P; Löwenberg B
Effects of human interleukin-3 on granulocytic colony-forming cells in human bone marrow.
Blood 1989;73(5):1157-60.
1989: Salem M; Delwel R; Mahmoud L A; Clark S; Elbasousy E M; Löwenberg B
Maturation of human acute myeloid leukaemia in vitro: the response to five recombinant haematopoietic factors in a serum-free system.
British journal of haematology 1989;71(3):363-70.
1989: Zittoun R; Jehn U; Fière D; Haanen C; Löwenberg B; Willemze R; Abels J; Bury J; Peetermans M; Hayat M
Alternating v repeated postremission treatment in adult acute myelogenous leukemia: a randomized phase III study (AML6) of the EORTC Leukemia Cooperative Group.
Blood 1989;73(4):896-906.
1989: Bot F J; van Eijk L; Schipper P; Löwenberg B
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates immature marrow precursors but no CFU-GM, CFU-G, or CFU-M.
Experimental hematology 1989;17(3):292-5.
1989: Bot F J; van Eijk L; Broeders L; Aarden L A; Löwenberg B
Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells.
Blood 1989;73(2):435-7.
1989: Löwenberg B; Touw I
Leukemic hematopoiesis in vitro: acute myeloid leukemia.
Bone marrow transplantation 1989;4 Suppl 1():5-8.
1989: Schouten H C; Delwel R; Bot F J; Hagemeijer A; Touw I P; Löwenberg B
Characterization of clonogenic cells in refractory anemia with excess of blasts (RAEB-CFU): response to recombinant hematopoietic growth factors and maturation phenotypes.
Leukemia research 1989;13(3):245-51.
1989: Pulsoni A; Delwel R; Salem M; Touw I; Löwenberg B
Cell to cell contact enhances the proliferation of acute myeloid leukemia (AML) cells in vitro without an apparent role of adhesion glycoproteins LFA1, MAC1 and P150-95.
Leukemia research 1989;13(10):883-91.
1989: Moberts R; Hoogerbrugge H; van Agthoven T; Löwenberg B; Touw I
Proliferative response of highly purified B chronic lymphocytic leukemia cells in serum free culture to interleukin-2 and tumor necrosis factors alpha and beta.
Leukemia research 1989;13(11):973-80.
1988: Delwel R; Salem M; Pellens C; Dorssers L; Wagemaker G; Clark S; Löwenberg B
Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system.
Blood 1988;72(6):1944-9.
1988: Delwel R; van Gurp R; Bot F; Touw I; Löwenberg B
Phenotyping of acute myelocytic leukemia (AML) progenitors: an approach for tracing minimal numbers of AML cells among normal bone marrow.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(12):814-9.
1988: Willemze R; Jager U; Jehn U; Stryckmans P; Bury J; Suciu S; Solbu G; Zittoun R; Burghouts J; Löwenberg B
Intermediate and high dose Ara-C and m-AMSA for remission induction and consolidation treatment of patients with acute myeloid leukemia: an EORTC Leukemia Cooperative Group phase II study.
European journal of cancer & clinical oncology 1988;24(11):1721-5.
1988: Löwenberg B; Touw I
Hematopoietic growth factors and human acute leukemia.
Schweizerische medizinische Wochenschrift 1988;118(42):1506-9.
1988: Schouten H C; Sizoo W; van 't Veer M B; Hagenbeek A; Löwenberg B
Incomplete chimerism in erythroid, myeloid and B lymphocyte lineage after T cell-depleted allogeneic bone marrow transplantation.
Bone marrow transplantation 1988;3(5):407-12.
1988: Bot F J; Dorssers L; Wagemaker G; Löwenberg B
Stimulating spectrum of human recombinant multi-CSF (IL-3) on human marrow precursors: importance of accessory cells.
Blood 1988;71(6):1609-14.
1988: Adriaansen H J; van Dongen J J; Hooijkaas H; Hählen K; van 't Veer M B; Löwenberg B; Hagemeijer A
Translocation (6;9) may be associated with a specific TdT-positive immunological phenotype in ANLL.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(3):136-40.
1988: Salem M; Delwel R; Touw I; Mahmoud L; Löwenberg B
Human AML colony growth in serum-free culture.
Leukemia research 1988;12(2):157-65.
1988: Löwenberg B; Salem M; Delwel R
Effects of recombinant multi-CSF, GM-CSF, G-CSF and M-CSF on the proliferation and maturation of human AML in vitro.
Blood cells 1988;14(2-3):539-49.
1987: Sizoo W; Hagenbeek A; Löwenberg B; van 't Veer M B; Sintnicolaas K
[Myelodysplastic syndromes]
Nederlands tijdschrift voor geneeskunde 1987;131(38):1658-61.
1987: Delwel R; Dorssers L; Touw I; Wagemaker G; Löwenberg B
Human recombinant multilineage colony stimulating factor (interleukin-3): stimulator of acute myelocytic leukemia progenitor cells in vitro.
Blood 1987;70(1):333-6.
1987: Touw I; Dorssers L; Löwenberg B
The proliferative response of B cell chronic lymphocytic leukemia to interleukin 2: functional characterization of the interleukin 2 membrane receptors.
Blood 1987;69(6):1667-73.
1987: Dorssers L; Burger H; Bot F; Delwel R; Geurts van Kessel A H; Löwenberg B; Wagemaker G
Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3.
Gene 1987;55(1):115-24.
1987: Löwenberg B; Abels J; van Bekkum D W; Sizoo W; Hendriks W D; van't Veer M B; Wagemaker G; Sintnicolaas K; Hagenbeek A
Treatment of patients with acute myeloid leukemia in first remission with marrow ablative therapy and autologous bone marrow transplantation.
Haematology and blood transfusion 1987;30():233-6.
1986: Löwenberg B; Wagemaker G; van Bekkum D W; Sizoo W; Sintnicolaas K; Hendriks W D; Hagenbeek A
Graft-versus-host disease following transplantation of 'one log' versus 'two log' T-lymphocyte-depleted bone marrow from HLA-identical donors.
Bone marrow transplantation 1986;1(2):133-40.
1986: Löwenberg B; Sizoo W; Wagemaker G; Sintnicolaas K; Hendriks W D; Hagenbeek A
[Prevention of graft-versus-host disease following allogeneic bone marrow transplantation in patients with leukemia]
Nederlands tijdschrift voor geneeskunde 1986;130(19):872-6.
1985: Hagenbeek A; Hendriks W D; Sizoo W; Sintnicolaas K; Löwenberg B
[Successful bone marrow transplantation in a patient with non-Hodgkin lymphoma of high-grade malignancy with invasion of the central nervous system]
Nederlands tijdschrift voor geneeskunde 1985;129(15):698-700.
1984: Löwenberg B; Abels J; van Bekkum D W; Dzoljic G; Hagenbeek A; Hendriks W D; van de Poel J; Sizoo W; Sintnicolaas K; Wagemaker G
Transplantation of non-purified autologous bone marrow in patients with AML in first remission.
Cancer 1984;54(12):2840-3.
1984: Hendriks W D; Sizoo W; Löwenberg B; Hagenbeek A
[Bacteriologic management of patients with decreased resistance]
Nederlands tijdschrift voor geneeskunde 1984;128(7):305-10.
1983: Löwenberg B; Abels J; van Bekkum D W; Dzoljic G; Hendriks W D; van der Poel J; Sizoo W; Sintnicolaas K; Wagemaker G
[Transplantation of autologous bone marrow in 3 patients with acute myeloid leukemia in first remission; initial experiences with a new treatment]
Nederlands tijdschrift voor geneeskunde 1983;127(30):1329-32.

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