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William Lown

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TOP 3
Rohtash Kumar; J William Lown
Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates.
Rohtash Kumar; Dinesh Rai; J William Lown
Synthesis and in vitro cytotoxicity studies of novel L-tryptophan-polyamide conjugates and L-tryptophan dimers linked with aliphatic chains and polyamides.
Rohtash Kumar; J William Lown
Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo [2,1][1,4] benzodiazepine-glycosylated pyrrole and imidazole polyamide conjugates.

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All Publications

2005: Rohtash Kumar; J William Lown
Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates.
European journal of medicinal chemistry 2005;40(7):641-54.
2004: Rohtash Kumar; Dinesh Rai; J William Lown
Synthesis and in vitro cytotoxicity studies of novel L-tryptophan-polyamide conjugates and L-tryptophan dimers linked with aliphatic chains and polyamides.
Oncology research 2004;14(4-5):247-65.
2003: Rohtash Kumar; J William Lown
Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo [2,1][1,4] benzodiazepine-glycosylated pyrrole and imidazole polyamide conjugates.
Organic & biomolecular chemistry 2003;1(19):3327-42.
2003: Rohtash Kumar; J William Lown
Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates.
Organic & biomolecular chemistry 2003;1(15):2630-47.
2003: Rohtash Kumar; J William Lown
Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation.
Mini reviews in medicinal chemistry 2003;3(4):323-39.
2003: Rohtash Kumar; J William Lown
Synthesis and antitumor cytotoxicity evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine imidazole containing polyamide conjugates.
Oncology research 2003;13(4):221-33.
2002: Sanjay K Sharma; Jean-Noël Billaud; Manju Tandon; Olivier Billet; Sam Choi; Mary L Kopka; Tom R Phillips; J William Lown
Inhibition of feline immunodeficiency virus (FIV) replication by DNA binding polyamides.
Bioorganic & medicinal chemistry letters 2002;12(15):2007-10.
2002: Rohtash Kumar; J William Lown
Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates.
Organic letters 2002;4(11):1851-4.
2002: Sham M Sondhi; Nidhi Singhal; Monika Johar; B S Narayan Reddy; J William Lown
Heterocyclic compounds as inflammation inhibitors.
Current medicinal chemistry 2002;9(10):1045-74.
2002: Hongmao Tang; James Sandeluk; Linda Lin; J William Lown
A new all-season passive sampling system for monitoring H2S in air.
TheScientificWorldJournal 2002;2():155-68.
2002: C Caroline O'Hare; Darcy Mack; Manju Tandon; Sanjay K Sharma; J William Lown; Mary L Kopka; Richard E Dickerson; John A Hartley
DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):72-7.
2001: B S Reddy; Sanjay K Sharma; J William Lown
Recent developments in sequence selective minor groove DNA effectors.
Current medicinal chemistry 2001;8(5):475-508.
2001: Sanjay K Sharma; A T Morrissey; Gerald G Miller; William H Gmeiner; J William Lown
Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin.
Bioorganic & medicinal chemistry letters 2001;11(6):769-72.
2001: M Helm; Mary L Kopka; Sanjay K Sharma; J William Lown; Richard Giegé
RNase activity of a DNA minor groove binder with a minimalist catalytic motif from RNase A.
Biochemical and biophysical research communications 2001;281(5):1283-90.
2001: Sanjay K Sharma; Manju Tandon; J William Lown
A general solution- and solid-phase synthetic procedure for incorporating three contiguous imidazole moieties into DNA sequence reading polyamides.
The Journal of organic chemistry 2001;66(3):1030-4.
2000: A K Singh; J William Lown
Design, synthesis and antitumor cytotoxicity of novel bis-benzimidazoles.
Anti-cancer drug design 2000;15(4):265-75.
2000: William H Gmeiner; Wei Cui; S Sharma; Ana Maria Soto; Luis A Marky; J William Lown
Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence.
Nucleosides, nucleotides & nucleic acids 2000;19(8):1365-79.
2000: B S Reddy; Y Damayanthi; B S Reddy; J William Lown
Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)--polymade conjugates and 2,2'-PBD dimers.
Anti-cancer drug design 2000;15(3):225-38.
2000: Q Ding; G Jia; J William Lown
Synthesis and antitumor cytotoxicity evaluation of pyrido[4,3,2-de]quinolines and isoquinolino[6,5,4,3-cde]quinolines.
Anti-cancer drug design 2000;15(2):99-108.
2000: S K Sharma; M Tandon; J William Lown
Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin.
The Journal of organic chemistry 2000;65(4):1102-7.
1999: William H Gmeiner; Wei Cui; David Konerding; Paul A Keifer; S K Sharma; Ana Maria Soto; Luis A Marky; J William Lown
Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins.
Journal of biomolecular structure & dynamics 1999;17(3):507-18.
1999: B S Reddy; Sham M Sondhi; J William Lown
Synthetic DNA minor groove-binding drugs.
Pharmacology & therapeutics 1999;84(1):1-111.
1999: K J Soderlind; B Gorodetsky; A K Singh; N R Bachur; Gerald G Miller; J William Lown
Bis-benzimidazole anticancer agents: targeting human tumour helicases.
Anti-cancer drug design 1999;14(1):19-36.
1999: Q Ding; K Chichak; J William Lown
Pyrroloquinoline and pyridoacridine alkaloids from marine sources.
Current medicinal chemistry 1999;6(1):1-27.
1998: Nouri Neamati; A Mazumder; S Sunder; J M Owen; M Tandon; J William Lown; Yves Pommier
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1998;54(2):280-90.
1998: Y Damayanthi; J William Lown
Podophyllotoxins: current status and recent developments.
Current medicinal chemistry 1998;5(3):205-52.
1998: Zhengwen Xiao; Gerald G Miller; T J McCallum; K M Brown; J William Lown; John Tulip; Ronald B Moore
Biodistribution of Photofrin II and 5-aminolevulinic acid-induced protoporphyrin IX in normal rat bladder and bladder tumor models: implications for photodynamic therapy.
Photochemistry and photobiology 1998;67(5):573-83.
1998: R Zhao; Le Luo Guan; B Oreski; J William Lown
Synthesis, topoisomerase I inhibitory activity and in vitro cytotoxicity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents.
Anti-cancer drug design 1998;13(2):145-57.
1997: Mary L Kopka; DS Goodsell; Gye Won Han; Thang Kien Chiu; J William Lown; Richard E Dickerson
Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G.
Structure (London, England : 1993) 1997;5(8):1033-46.
1997: Y Xie; Gerald G Miller; S A Cubitt; K J Soderlind; M Joan Allalunis-Turner; J William Lown
Enediyne-lexitropsin DNA-targeted anticancer agents. Physicochemical and cytotoxic properties in human neoplastic cells in vitro, and intracellular distribution.
Anti-cancer drug design 1997;12(3):169-79.
1997: Gerald G Miller; K Brown; AM Ballangrud; O Barajas; Zhengwen Xiao; John Tulip; J William Lown; J M Leithoff; M Joan Allalunis-Turner; R D Mehta; Ronald B Moore
Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update.
Photochemistry and photobiology 1997;65(4):714-22.
1997: Le Luo Guan; R Zhao; J William Lown
Enhanced DNA alkylation activities of Hoechst 33258 analogues designed for bioreductive activation.
Biochemical and biophysical research communications 1997;231(1):94-8.
1997: R Zhao; N H al-Said; D L Sternbach; J William Lown
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
Journal of medicinal chemistry 1997;40(2):216-25.