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Douglas Lowrie

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Eleanor Roy; John Brennan; Stephen Jolles; Douglas B Lowrie
Beneficial effect of anti-interleukin-4 antibody when administered in a murine model of tuberculosis infection.
Eleanor Roy; Douglas B Lowrie; Stephen Jolles
Current strategies in TB immunotherapy.
Gustavo Stadthagen; Mary Jackson; Patricia Charles; Frédéric Boudou; Nathalie Barilone; Michel Huerre; Patricia Constant; Avraham Liav; Iveta Bottova; Jerome Nigou; Thérèse Brando; Germain Puzo; Mamadou Daffé; Pearline Benjamin; Stephen Coade; Roger S Buxton; Ricardo E Tascon; Aaron Rae; Brian D Robertson; Douglas B Lowrie; Douglas B Young; Brigitte Gicquel; Ruth Griffin
Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.

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All Publications

2008: Eleanor Roy; John Brennan; Stephen Jolles; Douglas B Lowrie
Beneficial effect of anti-interleukin-4 antibody when administered in a murine model of tuberculosis infection.
Tuberculosis (Edinburgh, Scotland) 2008;88(3):197-202.
2007: Eleanor Roy; Douglas B Lowrie; Stephen Jolles
Current strategies in TB immunotherapy.
Current molecular medicine 2007;7(4):373-86.
2006: Gustavo Stadthagen; Mary Jackson; Patricia Charles; Frédéric Boudou; Nathalie Barilone; Michel Huerre; Patricia Constant; Avraham Liav; Iveta Bottova; Jerome Nigou; Thérèse Brando; Germain Puzo; Mamadou Daffé; Pearline Benjamin; Stephen Coade; Roger S Buxton; Ricardo E Tascon; Aaron Rae; Brian D Robertson; Douglas B Lowrie; Douglas B Young; Brigitte Gicquel; Ruth Griffin
Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.
Microbes and infection / Institut Pasteur 2006;8(8):2245-53.
2006: Douglas B Lowrie
DNA vaccines for therapy of tuberculosis: where are we now?
Vaccine 2006;24(12):1983-9.
2005: Eleanor Roy; Evangelos Stavropoulos; John Brennan; Stephen Coade; Elena Grigorieva; Barry Walker; Belinda Dagg; Ricardo E Tascon; Douglas B Lowrie; M Joseph Colston; Stephen Jolles
Therapeutic efficacy of high-dose intravenous immunoglobulin in Mycobacterium tuberculosis infection in mice.
Infection and immunity 2005;73(9):6101-9.
2005: Margot A Skinner; D Neil Wedlock; Geoffrey W de Lisle; Michèle M Cooke; Ricardo E Tascon; Jose Candido Ferraz; Douglas B Lowrie; Martin Vordermeier; R Glyn Hewinson; Bryce M Buddle
The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis.
Infection and immunity 2005;73(7):4441-4.
2004: Jose Candido Ferraz; Evangelos Stavropoulos; Min Yang; Stephen Coade; Clara Espitia; Douglas B Lowrie; M Joseph Colston; Ricardo E Tascon
A heterologous DNA priming-Mycobacterium bovis BCG boosting immunization strategy using mycobacterial Hsp70, Hsp65, and Apa antigens improves protection against tuberculosis in mice.
Infection and immunity 2004;72(12):6945-50.
2004: Tian Xue; Evangelos Stavropoulos; Min Yang; Silvia Ragno; Martin Vordermeier; Mark Chambers; Glyn Hewinson; Douglas B Lowrie; M Joseph Colston; Ricardo E Tascon
RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection.
Infection and immunity 2004;72(11):6324-9.
2004: Pål Johansen; Panagiota Stamou; Ricardo E Tascon; Douglas B Lowrie; Brigitta Stockinger
CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells.
European journal of immunology 2004;34(1):91-7.
2003: Pål Johansen; Catherine Raynaud; Min Yang; M Joseph Colston; Ricardo E Tascon; Douglas B Lowrie
Anti-mycobacterial immunity induced by a single injection of M. leprae Hsp65-encoding plasmid DNA in biodegradable microparticles.
Immunology letters 2003;90(2-3):81-5.
2003: Margot A Skinner; Bryce M Buddle; D Neil Wedlock; Denise L Keen; Geoffrey W de Lisle; Ricardo E Tascon; Jose Candido Ferraz; Douglas B Lowrie; Paul J Cockle; Martin Vordermeier; R Glyn Hewinson
A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis.
Infection and immunity 2003;71(9):4901-7.
2003: Martin Vordermeier; Douglas B Lowrie; R Glyn Hewinson
Improved immunogenicity of DNA vaccination with mycobacterial HSP65 against bovine tuberculosis by protein boosting.
Veterinary microbiology 2003;93(4):349-59.
2003: Stig Tollefsen; Martin Vordermeier; Ingrid Olsen; Anne K Storset; Liv Jorun Reitan; D Clifford; Douglas B Lowrie; Harald Gotten Wiker; Kris Huygen; Glyn Hewinson; Iacob Mathiesen; Torunn Elisabeth Tjelle
DNA injection in combination with electroporation: a novel method for vaccination of farmed ruminants.
Scandinavian journal of immunology 2003;57(3):229-38.
2003: Douglas B Lowrie
DNA vaccination: an update.
Methods in molecular medicine 2003;87():377-90.
2002: Mark A Chambers; Ann Williams; Graham Hatch; Dolores Gavier-Widén; Graham Hall; Kris Huygen; Douglas B Lowrie; Philip D Marsh; R Glyn Hewinson
Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis.
Infection and immunity 2002;70(4):2159-65.
2001: Mark A Chambers; D Stagg; Dolores Gavier-Widén; Douglas B Lowrie; D Newell; R Glyn Hewinson
A DNA vaccine encoding MPB83 from Mycobacterium bovis reduces M. bovis dissemination to the kidneys of mice and is expressed in primary cell cultures of the European badger (Meles meles).
Research in veterinary science 2001;71(2):119-26.
2000: Martin Vordermeier; Paul J Cockle; Adam O Whelan; S Rhodes; Mark A Chambers; Derek J Clifford; K Huygen; Ricardo E Tascon; Douglas B Lowrie; M Joseph Colston; R Glyn Hewinson
Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test.
Vaccine 2000;19(9-10):1246-55.
2000: Douglas B Lowrie
Issues facing TB control (8). The future of BCG/vaccine development.
Scottish medical journal 2000;45(5 Suppl):57-8; discussion 59.
2000: Mark A Chambers; Martin Vordermeier; Adam O Whelan; N Commander; Ricardo E Tascon; Douglas B Lowrie; R Glyn Hewinson
Vaccination of mice and cattle with plasmid DNA encoding the Mycobacterium bovis antigen MPB83.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;30 Suppl 3():S283-7.
2000: Célio L Silva; Douglas B Lowrie
Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis.
Infection and immunity 2000;68(6):3269-74.
2000: Douglas B Lowrie; Célio L Silva
Enhancement of immunocompetence in tuberculosis by DNA vaccination.
Vaccine 2000;18(16):1712-6.
2000: D Gregory; Ricardo E Tascon; Douglas B Lowrie
Repeated use of qiagen columns in large-scale preparation of plasmid DNA.
Methods in molecular medicine 2000;29():35-6.
2000: Ricardo E Tascon; Silvia Ragno; Douglas B Lowrie; M Joseph Colston
Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8+ T cells.
Immunology 2000;99(1):1-7.
1999: Douglas B Lowrie; Ricardo E Tascon; V L D Bonato; V M F Lima; Lúcia H Faccioli; Evangelos Stavropoulos; M Joseph Colston; R Glyn Hewinson; K Moelling; Célio L Silva
Therapy of tuberculosis in mice by DNA vaccination.
Nature 1999;400(6741):269-71.
1999: Douglas B Lowrie
DNA vaccines against tuberculosis.
Current opinion in molecular therapeutics 1999;1(1):30-3.
1999: Omid Akbari; N Panjwani; S Garcia; Ricardo E Tascon; Douglas B Lowrie; Brigitta Stockinger
DNA vaccination: transfection and activation of dendritic cells as key events for immunity.
The Journal of experimental medicine 1999;189(1):169-78.
1998: Douglas B Lowrie; Célio L Silva; Ricardo E Tascon
Progress towards a new tuberculosis vaccine.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 1998;10(3):201-13.
1998: V L D Bonato; V M F Lima; Ricardo E Tascon; Douglas B Lowrie; Célio L Silva
Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice.
Infection and immunity 1998;66(1):169-75.
1997: Douglas B Lowrie; Célio L Silva; Ricardo E Tascon
DNA vaccines against tuberculosis.
Immunology and cell biology 1997;75(6):591-4.
1997: Douglas B Lowrie; Célio L Silva; M Joseph Colston; Silvia Ragno; Ricardo E Tascon
Protection against tuberculosis by a plasmid DNA vaccine.
Vaccine 1997;15(8):834-8.
1997: KV Lukacs; A Nakakes; Christopher J Atkins; Douglas B Lowrie; M Joseph Colston
In vivo gene therapy of malignant tumours with heat shock protein-65 gene.
Gene therapy 1997;4(4):346-50.
1997: Silvia Ragno; M Joseph Colston; Douglas B Lowrie; Vivienne R Winrow; David R Blake; Ricardo E Tascon
Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65.
Arthritis and rheumatism 1997;40(2):277-83.
1997: Douglas B Lowrie; Célio L Silva; Ricardo E Tascon
Genetic vaccination against tuberculosis.
Springer seminars in immunopathology 1997;19(2):161-73.
1996: Ricardo E Tascon; M Joseph Colston; Silvia Ragno; Evangelos Stavropoulos; D Gregory; Douglas B Lowrie
Vaccination against tuberculosis by DNA injection.
Nature medicine 1996;2(8):888-92.
1996: Célio L Silva; M F Silva; R C Pietro; Douglas B Lowrie
Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65.
Infection and immunity 1996;64(7):2400-7.
1995: Célio L Silva; R L Pietro; A Januario; V L D Bonato; V M F Lima; M F da Silva; Douglas B Lowrie
Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65.
Immunology 1995;86(4):519-24.
1995: Douglas B Lowrie; Ricardo E Tascon; Célio L Silva
Vaccination against tuberculosis.
International archives of allergy and immunology 1995;108(4):309-12.
1994: Douglas B Lowrie; Ricardo E Tascon; M Joseph Colston; Célio L Silva
Towards a DNA vaccine against tuberculosis.
Vaccine 1994;12(16):1537-40.
1994: Célio L Silva; M F Silva; R C Pietro; Douglas B Lowrie
Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65.
Immunology 1994;83(3):341-6.
1994: Célio L Silva; Douglas B Lowrie
A single mycobacterial protein (hsp 65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis.
Immunology 1994;82(2):244-8.
1993: KV Lukacs; Douglas B Lowrie; R W Stokes; M Joseph Colston
Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors.
The Journal of experimental medicine 1993;178(1):343-8.
1993: Célio L Silva; KV Lukacs; Douglas B Lowrie
Major histocompatibility complex non-restricted presentation to CD4+ T lymphocytes of Mycobacterium leprae heat-shock protein 65 antigen by macrophages transfected with the mycobacterial gene.
Immunology 1993;78(1):35-42.
1992: Célio L Silva; A Palacios; M Joseph Colston; Douglas B Lowrie
Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I.
Microbial pathogenesis 1992;12(1):27-38.