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Todd Lowther

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Haiqin Chen; Wei Chen; Zhennan Gu; W Todd Lowther; Mingxuan Wang; Hao Zhang; Yong Q Chen
Expression and purification of integral membrane fatty acid desaturases.
Travis J Riedel; Ross P Holmes; John Knight; Dawn S Milliner; Michael Murray; W Todd Lowther
4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition.
Juquan Jiang; Lynnette C Johnson; John Knight; Michael F Callahan; Ross P Holmes; Travis J Riedel; W Todd Lowther
Metabolism of [13C5]hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria.

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All Publications

2013: Haiqin Chen; Wei Chen; Zhennan Gu; W Todd Lowther; Mingxuan Wang; Hao Zhang; Yong Q Chen
Expression and purification of integral membrane fatty acid desaturases.
PloS one 2013;8(3):e58139.
2012: Travis J Riedel; Ross P Holmes; John Knight; Dawn S Milliner; Michael Murray; W Todd Lowther
4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition.
Biochimica et biophysica acta 2012;1822(10):1544-52.
2012: Juquan Jiang; Lynnette C Johnson; John Knight; Michael F Callahan; Ross P Holmes; Travis J Riedel; W Todd Lowther
Metabolism of [13C5]hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(6):G637-43.
2011: W Todd Lowther; Alexina C Haynes
Reduction of cysteine sulfinic acid in eukaryotic, typical 2-Cys peroxiredoxins by sulfiredoxin.
Antioxidants & redox signaling 2011;15(1):99-109.
2011: Travis J Riedel; Roy R Hantgan; Ross P Holmes; Lynnette C Johnson; John Knight; W Todd Lowther
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
PloS one 2011;6(10):e26021.
2010: Chananat Klomsiri; Kimberly J Nelson; Erika Bechtold; Laura Soito; Lynnette C Johnson; W Todd Lowther; Seong-Eon Ryu; S Bruce King; Cristina M Furdui; Leslie B Poole
Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.
Methods in enzymology 2010;473():77-94.
2009: Thomas J Jönsson; Lynnette C Johnson; W Todd Lowther
Protein engineering of the quaternary sulfiredoxin.peroxiredoxin enzyme.substrate complex reveals the molecular basis for cysteine sulfinic acid phosphorylation.
The Journal of biological chemistry 2009;284(48):33305-10.
2008: Thomas J Jönsson; Michael Murray; Lynnette C Johnson; W Todd Lowther
Reduction of cysteine sulfinic acid in peroxiredoxin by sulfiredoxin proceeds directly through a sulfinic phosphoryl ester intermediate.
The Journal of biological chemistry 2008;283(35):23846-51.
2008: Thomas J Jönsson; Allen W Tsang; W Todd Lowther; Cristina M Furdui
Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin.
The Journal of biological chemistry 2008;283(34):22890-4.
2008: Michael Murray; Ross P Holmes; W Todd Lowther
Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design.
Biochemistry 2008;47(8):2439-49.
2008: Thomas J Jönsson; Lynnette C Johnson; W Todd Lowther
Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace.
Nature 2008;451(7174):98-101.
2007: Steven J Kridel; W Todd Lowther; Charles W Pemble
Fatty acid synthase inhibitors: new directions for oncology.
Expert opinion on investigational drugs 2007;16(11):1817-29.
2007: Charles W Pemble; Lynnette C Johnson; Steven J Kridel; W Todd Lowther
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.
Nature structural & molecular biology 2007;14(8):704-9.
2007: Zhidong Lin; Lynnette C Johnson; Herbert Weissbach; Nathan Brot; Mark Lively; W Todd Lowther
Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9597-602.
2007: Thomas J Jönsson; W Todd Lowther
The peroxiredoxin repair proteins.
Sub-cellular biochemistry 2007;44():115-41.
2006: Nathan Brot; Jean Francois Collet; Lynnette C Johnson; Thomas J Jönsson; Herbert Weissbach; W Todd Lowther
The thioredoxin domain of Neisseria gonorrhoeae PilB can use electrons from DsbD to reduce downstream methionine sulfoxide reductases.
The Journal of biological chemistry 2006;281(43):32668-75.
2005: Thomas J Jönsson; Michael Murray; Lynnette C Johnson; Leslie B Poole; W Todd Lowther
Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
Biochemistry 2005;44(24):8634-42.
2002: W Todd Lowther; Brian W Matthews
Metalloaminopeptidases: common functional themes in disparate structural surroundings.
Chemical reviews 2002;102(12):4581-608.
2002: W Todd Lowther; Herbert Weissbach; Frantzy Etienne; Nathan Brot; Brian W Matthews
The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB.
Nature structural biology 2002;9(5):348-52.
2002: Herbert Weissbach; Frantzy Etienne; Toshinori Hoshi; Stefan H Heinemann; W Todd Lowther; Brian Matthews; Gregory St John; Carl Nathan; Nathan Brot
Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.
Archives of biochemistry and biophysics 2002;397(2):172-8.
2000: W Todd Lowther; Nathan Brot; Herbert Weissbach; Brian W Matthews
Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme.
Biochemistry 2000;39(44):13307-12.
2000: W Todd Lowther; Nathan Brot; Herbert Weissbach; John F Honek; Brian W Matthews
Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6463-8.
2000: W Todd Lowther; Brian W Matthews
Structure and function of the methionine aminopeptidases.
Biochimica et biophysica acta 2000;1477(1-2):157-67.
1999: W Todd Lowther; Y Zhang; Peter B Sampson; John F Honek; Brian W Matthews
Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
Biochemistry 1999;38(45):14810-9.
1999: W Todd Lowther; A M Orville; D T Madden; S Lim; D H Rich; Brian W Matthews
Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
Biochemistry 1999;38(24):7678-88.
1998: W Todd Lowther; Debra McMillen; A M Orville; Brian W Matthews
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12153-7.