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Shoshana Loya

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Ayelet Armon-Omer; Aviad Levin; Zvi Hayouka; Karin Butz; Felix Hoppe-Seyler; Shoshana Loya; Amnon Hizi; Assaf Friedler; Abraham Loyter
Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library.
Joseph Rosenbluh; Zvi Hayouka; Shoshana Loya; Aviad Levin; Ayelet Armon-Omer; Elena Britan; Amnon Hizi; Moshe Kotler; Assaf Friedler; Abraham Loyter
Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides.
Zvi Hayouka; Joseph Rosenbluh; Aviad Levin; Shoshana Loya; Mario Lebendiker; Dmitry B Veprintsev; Moshe Kotler; Amnon Hizi; Abraham Loyter; Assaf Friedler
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.

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All Publications

2008: Ayelet Armon-Omer; Aviad Levin; Zvi Hayouka; Karin Butz; Felix Hoppe-Seyler; Shoshana Loya; Amnon Hizi; Assaf Friedler; Abraham Loyter
Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library.
Journal of molecular biology 2008;376(4):971-82.
2007: Joseph Rosenbluh; Zvi Hayouka; Shoshana Loya; Aviad Levin; Ayelet Armon-Omer; Elena Britan; Amnon Hizi; Moshe Kotler; Assaf Friedler; Abraham Loyter
Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides.
The Journal of biological chemistry 2007;282(21):15743-53.
2007: Zvi Hayouka; Joseph Rosenbluh; Aviad Levin; Shoshana Loya; Mario Lebendiker; Dmitry B Veprintsev; Moshe Kotler; Amnon Hizi; Abraham Loyter; Assaf Friedler
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8316-21.
2003: Orna Avidan; Shoshana Loya; Ralf R Tönjes; Ziv Sevilya; Amnon Hizi
Expression and characterization of a recombinant novel reverse transcriptase of a porcine endogenous retrovirus.
Virology 2003;307(2):341-57.
2003: Ziv Sevilya; Shoshana Loya; Amit Duvshani; Noam Adir; Amnon Hizi
Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: the effects on the ribonuclease H activity.
Journal of molecular biology 2003;327(1):19-30.
2003: Ziv Sevilya; Shoshana Loya; N Adir; Amnon Hizi
The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is modulated by residue 294 of the small subunit.
Nucleic acids research 2003;31(5):1481-7.
2002: Shoshana Loya; Amira Rudi; Yoel Kashman; Amnon Hizi
Mode of inhibition of HIV-1 reverse transcriptase by polyacetylenetriol, a novel inhibitor of RNA- and DNA-directed DNA polymerases.
The Biochemical journal 2002;362(Pt 3):685-92.
2001: Amira Rudi; Tesfamariam Yosief; Shoshana Loya; Amnon Hizi; Michael Schleyer; Yoel Kashman
Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species.
Journal of natural products 2001;64(11):1451-3.
2001: Ziv Sevilya; Shoshana Loya; Stephen H Hughes; Amnon Hizi
The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is affected by the thumb subdomain of the small protein subunits.
Journal of molecular biology 2001;311(5):957-71.
2001: C Puder; Shoshana Loya; Amnon Hizi; Axel Zeeck
New co-metabolites of the streptazolin pathway.
Journal of natural products 2001;64(1):42-5.
1999: Shoshana Loya; Amira Rudi; Yoel Kashman; Amnon Hizi
Polycitone A, a novel and potent general inhibitor of retroviral reverse transcriptases and cellular DNA polymerases.
The Biochemical journal 1999;344 Pt 1():85-92.
1998: Shoshana Loya; Vered Reshef; E Mizrachi; C Silberstein; Y Rachamim; Shmuel Carmeli; Amnon Hizi
The inhibition of the reverse transcriptase of HIV-1 by the natural sulfoglycolipids from cyanobacteria: contribution of different moieties to their high potency.
Journal of natural products 1998;61(7):891-5.
1998: R Taube; Shoshana Loya; Orna Avidan; M Perach; Amnon Hizi
Reverse transcriptase of mouse mammary tumour virus: expression in bacteria, purification and biochemical characterization.
The Biochemical journal 1998;329 ( Pt 3)():579-87.
1997: Vered Reshef; E Mizrachi; T Maretzki; C Silberstein; Shoshana Loya; Amnon Hizi; Shmuel Carmeli
New acylated sulfoglycolipids and digalactolipids and related known glycolipids from cyanobacteria with a potential to inhibit the reverse transcriptase of HIV-1.
Journal of natural products 1997;60(12):1251-60.
1997: Shoshana Loya; Hong Qiang Gao; Orna Avidan; Paul L Boyer; Stephen H Hughes; Amnon Hizi
Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.
Journal of virology 1997;71(7):5668-72.
1997: Shoshana Loya; Amira Rudi; Yoel Kashman; Amnon Hizi
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases.
The Biochemical journal 1997;324 ( Pt 3)():721-7.
1995: Shoshana Loya; M Bakhanashvili; Yoel Kashman; Amnon Hizi
Mechanism of inhibition of HIV reverse transcriptase by toxiusol, a novel general inhibitor of retroviral and cellular DNA polymerases.
Biochemistry 1995;34(7):2260-6.
1995: Shoshana Loya; M Bakhanashvili; Yoel Kashman; Amnon Hizi
Peyssonols A and B, two novel inhibitors of the reverse transcriptases of human immunodeficiency virus types 1 and 2.
Archives of biochemistry and biophysics 1995;316(2):789-96.
1994: P Mohan; Shoshana Loya; Orna Avidan; S Verma; G S Dhindsa; M F Wong; P P Huang; M Yashiro; M Baba; Amnon Hizi
Synthesis of naphthalenesulfonic acid small molecules as selective inhibitors of the DNA polymerase and ribonuclease H activities of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 1994;37(16):2513-9.
1994: Shoshana Loya; M Bakhanashvili; R Tal; Stephen H Hughes; Paul L Boyer; Amnon Hizi
Enzymatic properties of two mutants of reverse transcriptase of human immunodeficiency virus type 1 (tyrosine 181-->isoleucine and tyrosine 188-->leucine), resistant to nonnucleoside inhibitors.
AIDS research and human retroviruses 1994;10(8):939-46.
1994: Shoshana Loya; Amira Rudi; R Tal; Yoel Kashman; Y Loya; Amnon Hizi
3,5,8-Trihydroxy-4-quinolone, a novel natural inhibitor of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2.
Archives of biochemistry and biophysics 1994;309(2):315-22.
1994: T Rubinek; Shoshana Loya; M Shaharabany; Stephen H Hughes; P K Clark; Amnon Hizi
The catalytic properties of the reverse transcriptase of the lentivirus equine infectious anemia virus.
European journal of biochemistry / FEBS 1994;219(3):977-83.
1993: Shoshana Loya; R Tal; Amnon Hizi; S Issacs; Yoel Kashman; Y Loya
Hexaprenoid hydroquinones, novel inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Journal of natural products 1993;56(12):2120-5.
1993: Shoshana Loya; Amnon Hizi
The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses.
The Journal of biological chemistry 1993;268(13):9323-8.
1992: Shoshana Loya; R Tal; Stephen H Hughes; Amnon Hizi
The effects of cysteine mutations on the catalytic activities of the reverse transcriptase of human immunodeficiency virus type-1.
The Journal of biological chemistry 1992;267(20):13879-83.
1992: A Vonsover; Shoshana Loya; Benjamin Sredni; Michael Albeck; T Gotlieb-Stematsky; O Araf; Amnon Hizi
Inhibition of the reverse transcriptase activity and replication of human immunodeficiency virus type 1 by AS 101 in vitro.
AIDS research and human retroviruses 1992;8(5):613-23.
1992: Shoshana Loya; Yoel Kashman; Amnon Hizi
The carotenoid halocynthiaxanthin: a novel inhibitor of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2.
Archives of biochemistry and biophysics 1992;293(2):208-12.
1991: Amnon Hizi; R Tal; M Shaharabany; Shoshana Loya
Catalytic properties of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2.
The Journal of biological chemistry 1991;266(10):6230-9.
1990: Shoshana Loya; R Tal; Yoel Kashman; Amnon Hizi
Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase.
Antimicrobial agents and chemotherapy 1990;34(10):2009-12.
1990: Shoshana Loya; Amnon Hizi
The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives.
FEBS letters 1990;269(1):131-4.