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Guillermina Lozano

Research Profile

Chemicals & Drugs

Living Beings

Genes & Molecular Sequences

Genes, p53

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Molecular Sequence Data

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Publications

TOP 3
Qin Li; Guillermina Lozano
Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.
James G Jackson; Guillermina Lozano
Che-ating death: CHE1/AATF protects from p53-mediated apoptosis.
Elsa R Flores; Guillermina Lozano
The p53 family grows old.

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All Publications

2013: Qin Li; Guillermina Lozano
Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):34-41.
2012: James G Jackson; Guillermina Lozano
Che-ating death: CHE1/AATF protects from p53-mediated apoptosis.
The EMBO journal 2012;31(20):3951-3.
2012: Elsa R Flores; Guillermina Lozano
The p53 family grows old.
Genes & development 2012;26(18):1997-2000.
2012: James G Jackson; Qin Li; Yi Li; Taghi Manshouri; Vinod Pant; Alfonso Quintás-Cardama; Omid Tavana; Peirong Yang; Leslie L Chang; Adel K El-Naggar; Daniel Garza; Guillermina Lozano
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.
Cancer cell 2012;21(6):793-806.
2012: Maurisa F Riley; Guillermina Lozano
The Many Faces of MDM2 Binding Partners.
Genes & cancer 2012;3(3-4):226-39.
2011: Young-Ah Suh; Tamara Terzian; Carolyn Van Pelt; Daniela R Maccio; Sean M Post; Ana C Elizondo-Fraire; Adel K El-Naggar; James G Jackson; Guillermina Lozano
Multiple stress signals activate mutant p53 in vivo.
Cancer research 2011;71(23):7168-75.
2011: Hussein A Abbas; Vinod Pant; Guillermina Lozano
The ups and downs of p53 regulation in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.) 2011;10(19):3257-62.
2011: Michelle D Williams; Li Zhang; Gary L Clayman; Danielle D Elliott; Guillermina Lozano; Nancy D Perrier; Adel K El-Naggar
Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas.
Human pathology 2011;42(9):1213-20.
2011: Tamara Terzian; Christina Thaller; Farinaz Arbab; Lawrence A Donehower; Melissa Dumble; Monica J Justice; Guillermina Lozano; Dennis R Roop; Neil Box
Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.
The Journal of pathology 2011;224(4):540-52.
2011: Vinod Pant; Alfonso Quintás-Cardama; Shunbin Xiong; Tomoo Iwakuma; Guillermina Lozano
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):11995-2000.
2011: Chih-Chieh Wu; Ralf Krahe; Guillermina Lozano; Baili Zhang; Charmaine D Wilson; Eun-Ji Jo; Christopher I Amos; Sanjay Shete; Louise C Strong
Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.
Human genetics 2011;129(6):663-73.
2011: Yongxing Wang; Young-Ah Suh; Maren Y Fuller; James G Jackson; Shunbin Xiong; Tamara Terzian; Alfonso Quintás-Cardama; James Bankson; Adel K El-Naggar; Guillermina Lozano
Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation.
The Journal of clinical investigation 2011;121(3):893-904.
2011: James G Jackson; Sean M Post; Guillermina Lozano
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
The Journal of pathology 2011;223(2):127-36.
2011: Patrick P Lin; Yongxing Wang; Guillermina Lozano
Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma.
Sarcoma 2011;2011():.
2010: L Tian; G Peng; John M Parant; Vasiliki Leventaki; Elias Drakos; Qing Zhang; Jan Parker-Thornburg; T J Shackleford; H Dai; Shiaw-Yih Lin; Guillermina Lozano; George Z Rassidakis; Francois Claret
Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.
Oncogene 2010;29(46):6125-37.
2010: Hussein A Abbas; Daniela R Maccio; Suleyman Coskun; James G Jackson; Amy L Hazen; Tiffany M Sills; M James You; Karen K Hirschi; Guillermina Lozano
Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Cell stem cell 2010;7(5):606-17.
2010: Sean M Post; Guillermina Lozano
You can win by losing: p53 mutations in rhabdomyosarcomas.
The Journal of pathology 2010;222(2):124-8.
2010: Shunbin Xiong; Vinod Pant; Young-Ah Suh; Carolyn S Van Pelt; Yongxing Wang; Yasmine A Valentin-Vega; Sean M Post; Guillermina Lozano
Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.
Cancer research 2010;70(18):7148-54.
2010: Sean M Post; Alfonso Quintás-Cardama; Vinod Pant; Tomoo Iwakuma; Amir Hamir; James G Jackson; Daniela R Maccio; Gareth Bond; David G Johnson; Arnold J Levine; Guillermina Lozano
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Cancer cell 2010;18(3):220-30.
2010: Roza I Nurieva; Shuling Zheng; Wei Jin; Yeonseok Chung; Yongliang Zhang; Gustavo J Martinez; Joseph M Reynolds; Sung-Ling Wang; Xin Lin; Shao-Cong Sun; Guillermina Lozano; Chen Dong
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.
Immunity 2010;32(5):670-80.
2010: Guillermina Lozano
Mouse models of p53 functions.
Cold Spring Harbor perspectives in biology 2010;2(4):a001115.
2010: S M Post; A Quintás-Cardama; Tamara Terzian; C Smith; C M Eischen; Guillermina Lozano
p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
Oncogene 2010;29(9):1260-9.
2010: Shenying Fang; Ralf Krahe; Guillermina Lozano; Younghun Han; Wei Chen; Sean M Post; Baili Zhang; Charmaine D Wilson; Linda L Bachinski; Louise C Strong; Christopher I Amos
Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.
PloS one 2010;5(5):e10813.
2009: Lawrence A Donehower; Guillermina Lozano
20 years studying p53 functions in genetically engineered mice.
Nature reviews. Cancer 2009;9(11):831-41.
2009: Patrick P Lin; Manoj Pandey; Fenghua Jin; A Kevin Raymond; Haruhiko Akiyama; Guillermina Lozano
Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice.
Carcinogenesis 2009;30(10):1789-95.
2009: Yasmine A Valentin-Vega; Neil Box; Tamara Terzian; Guillermina Lozano
Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities.
Differentiation; research in biological diversity 2009;77(5):442-9.
2009: Don L Gibbons; Wei Lin; Chad J Creighton; Shuling Zheng; Dror Berel; Y Yang; Maria Gabriela Raso; Diane D Liu; Ignacio I Wistuba; Guillermina Lozano; Jonathan M Kurie
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
PloS one 2009;4(4):e5401.
2008: Patrick P Lin; Manoj Pandey; Fenghua Jin; Shunbin Xiong; Michael Deavers; John M Parant; Guillermina Lozano
EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.
Cancer research 2008;68(21):8968-75.
2008: Yasmine A Valentin-Vega; H Okano; Guillermina Lozano
The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.
Cell death and differentiation 2008;15(11):1772-81.
2008: Juan A Barboza; Tomoo Iwakuma; Tamara Terzian; Adel K El-Naggar; Guillermina Lozano
Mdm2 and Mdm4 loss regulates distinct p53 activities.
Molecular cancer research : MCR 2008;6(6):947-54.
2008: Tamara Terzian; Young-Ah Suh; Tomoo Iwakuma; Sean M Post; Manja Neumann; Gene A Lang; Carolyn S Van Pelt; Guillermina Lozano
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Genes & development 2008;22(10):1337-44.
2008: Gurinder Singh Atwal; Raúl Rabadán; Guillermina Lozano; Louise C Strong; Mariëlle W G Ruijs; Marjanka K Schmidt; Laura J van't Veer; Heli Nevanlinna; Johanna Tommiska; Kristiina Aittomäki; Gaelle Bougeard; Thierry Frebourg; Arnold J Levine; Gareth Bond
An information-theoretic analysis of genetics, gender and age in cancer patients.
PloS one 2008;3(4):e1951.
2007: Geng Liu; Tamara Terzian; S Xiong; C S Van Pelt; A Audiffred; Neil Box; Guillermina Lozano
The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development.
The Journal of pathology 2007;213(4):360-8.
2007: S Zheng; Adel K El-Naggar; E S Kim; Jonathan M Kurie; Guillermina Lozano
A genetic mouse model for metastatic lung cancer with gender differences in survival.
Oncogene 2007;26(48):6896-904.
2007: Yasmine A Valentin-Vega; Juan A Barboza; Gilda P Chau; Adel K El-Naggar; Guillermina Lozano
High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.
Human pathology 2007;38(10):1553-62.
2007: Tamara Terzian; Yongxing Wang; Carolyn S Van Pelt; Neil Box; Elisabeth L Travis; Guillermina Lozano
Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Molecular and cellular biology 2007;27(15):5479-85.
2007: Carlos Caulin; Thao Nguyen; Gene A Lang; Thea M Goepfert; Bill R Brinkley; Wei-Wen Cai; Guillermina Lozano; Dennis R Roop
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
The Journal of clinical investigation 2007;117(7):1893-901.
2007: Shunbin Xiong; Carolyn S Van Pelt; Ana C Elizondo-Fraire; Belen Fernandez-Garcia; Guillermina Lozano
Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.
Circulation 2007;115(23):2925-30.
2007: Joanna G Koch; Xiangjun Gu; Younghun Han; Adel K El-Naggar; Melissa V Olson; Daniel Medina; D Joseph Jerry; Anneke C Blackburn; Gary Peltz; Christopher I Amos; Guillermina Lozano
Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(5):300-9.
2007: Ping Bu; Yvonne A Evrard; Guillermina Lozano; Sharon Y R Dent
Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.
Molecular and cellular biology 2007;27(9):3405-16.
2007: Guillermina Lozano; Richard R Behringer
New mouse models of cancer: single-cell knockouts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4245-6.
2007: Guillermina Lozano
The oncogenic roles of p53 mutants in mouse models.
Current opinion in genetics & development 2007;17(1):66-70.
2007: Xin Han; Guillermo Garcia-Manero; Timothy J McDonnell; Guillermina Lozano; L Jeffrey Medeiros; Lianchun Xiao; Gary Rosner; Martin Nguyen; Michael Fernandez; Yasmine A Valentin-Vega; Juan A Barboza; Daniel M Jones; George Z Rassidakis; Hagop M Kantarjian; Carlos E Bueso-Ramos
HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(1):54-62.
2006: Juan A Barboza; Geng Liu; Zhenlin Ju; Adel K El-Naggar; Guillermina Lozano
p21 delays tumor onset by preservation of chromosomal stability.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19842-7.
2006: Bernard Ayanga; Roger Price; Xiangjun Gu; Guillermina Lozano; Susan C Evans
Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice.
Genes, chromosomes & cancer 2006;45(7):668-75.
2006: Mong-Hong Lee; Guillermina Lozano
Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.
Seminars in cancer biology 2006;16(3):225-34.
2006: Shunbin Xiong; Carolyn S Van Pelt; Ana C Elizondo-Fraire; Geng Liu; Guillermina Lozano
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3226-31.
2006: Jason D Grier; Shunbin Xiong; Ana C Elizondo-Fraire; John M Parant; Guillermina Lozano
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Molecular and cellular biology 2006;26(1):192-8.
2005: Andrew Slack; Guillermina Lozano; Jason M Shohet
MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis.
Cancer letters 2005;228(1-2):21-7.
2005: Guillermina Lozano; Gerard P Zambetti
Gankyrin: an intriguing name for a novel regulator of p53 and RB.
Cancer cell 2005;8(1):3-4.
2005: Tomoo Iwakuma; Guillermina Lozano; Elsa R Flores
Li-Fraumeni syndrome: a p53 family affair.
Cell cycle (Georgetown, Tex.) 2005;4(7):865-7.
2005: Wendong Huang; Jun Zhang; Michele Washington; Jun Liu; John M Parant; Guillermina Lozano; David D Moore
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1646-53.
2005: Geng Liu; Guillermina Lozano
p21 stability: linking chaperones to a cell cycle checkpoint.
Cancer cell 2005;7(2):113-4.
2005: Linda L Bachinski; Shodimu-Emmanuel Olufemi; Xiaojun Zhou; Chih-Chieh Wu; Linwah Yip; Sanjay Shete; Guillermina Lozano; Christopher I Amos; Louise C Strong; Ralf Krahe
Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23.
Cancer research 2005;65(2):427-31.
2005: Guillermina Lozano; Gerard P Zambetti
What have animal models taught us about the p53 pathway?
The Journal of pathology 2005;205(2):206-20.
2004: Gene A Lang; Tomoo Iwakuma; Young-Ah Suh; Geng Liu; V Ashutosh Rao; John M Parant; Yasmine A Valentin-Vega; Tamara Terzian; Lisa C Caldwell; Louise C Strong; Adel K El-Naggar; Guillermina Lozano
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Cell 2004;119(6):861-72.
2004: Zheng Li; Chi-Ping Day; Jer-Yen Yang; Wen-Bin Tsai; Guillermina Lozano; Hsiu-Ming Shih; Mien-Chie Hung
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Cancer research 2004;64(24):9080-5.
2004: Gareth Bond; Wenwei Hu; Elisabeth E Bond; Harlan Robins; Stuart G Lutzker; Nicoleta C Arva; Jill Bargonetti; Frank Bartel; Helge Taubert; Peter Wuerl; Kenan Onel; Linwah Yip; Shih-Jen Hwang; Louise C Strong; Guillermina Lozano; Arnold J Levine
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Cell 2004;119(5):591-602.
2004: Tomoo Iwakuma; John M Parant; Mark Fasulo; Edwin Zwart; Tyler Jacks; Annemieke de Vries; Guillermina Lozano
Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
Oncogene 2004;23(46):7644-50.
2004: Wendy Bruins; Edwin Zwart; Laura D Attardi; Tomoo Iwakuma; Esther M Hoogervorst; Rudolf B Beems; Barbara Miranda; Conny Th M van Oostrom; Jolanda van den Berg; Gerard van den Aardweg; Guillermina Lozano; Harry van Steeg; Tyler Jacks; Annemieke de Vries
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Molecular and cellular biology 2004;24(20):8884-94.
2004: Susan C Evans; Min Liang; Christopher I Amos; Xiangjun Gu; Guillermina Lozano
A novel genetic modifier of p53, mop1, results in embryonic lethality.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(6):415-23.
2004: Mandri Obeyesekere; Edwin Tecarro; Guillermina Lozano
Model predictions of MDM2 mediated cell regulation.
Cell cycle (Georgetown, Tex.) 2004;3(5):655-61.
2004: Geng Liu; John M Parant; Gene Lang; Patty Chau; Arturo Chavez-Reyes; Adel K El-Naggar; Asha S Multani; Sandy Chang; Guillermina Lozano
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.
Nature genetics 2004;36(1):63-8.
2003: Arturo Chavez-Reyes; John M Parant; Lisa L Amelse; Roberto Montes de Oca Luna; Stanley J Korsmeyer; Guillermina Lozano
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Cancer research 2003;63(24):8664-9.
2003: Tomoo Iwakuma; Guillermina Lozano
MDM2, an introduction.
Molecular cancer research : MCR 2003;1(14):993-1000.
2003: Heng-Yin Yang; Yu-Ye Wen; Chih-Hsin Chen; Guillermina Lozano; Mong-Hong Lee
14-3-3 sigma positively regulates p53 and suppresses tumor growth.
Molecular and cellular biology 2003;23(20):7096-107.
2003: Shih-Jen Hwang; Li Shu-Chung Cheng; Guillermina Lozano; Christopher I Amos; Xiangjun Gu; Louise C Strong
Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk.
Human genetics 2003;113(3):238-43.
2003: Shih-Jen Hwang; Guillermina Lozano; Christopher I Amos; Louise C Strong
Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk.
American journal of human genetics 2003;72(4):975-83.
2003: Roger P Leng; Yunping Lin; Weili Ma; Hong Wu; Bénédicte Lemmers; Stephen Chung; John M Parant; Guillermina Lozano; Raza Hakem; Samuel Benchimol
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.
Cell 2003;112(6):779-91.
2003: John M Parant; Guillermina Lozano
Disrupting TP53 in mouse models of human cancers.
Human mutation 2003;21(3):321-6.
2003: Xiongbin Lu; Guillermina Lozano; Lawrence A Donehower
Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system.
Mutation research 2003;522(1-2):69-83.
2002: James R Jabbur; Amy D Tabor; Xiaodong Cheng; Hua Wang; Motonari Uesugi; Guillermina Lozano; Wei Zhang
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.
Oncogene 2002;21(46):7100-13.
2002: Jijie Gu; Hidehiko Kawai; Linghu Nie; Hiroyuki Kitao; Dmitri Wiederschain; Aart G Jochemsen; John M Parant; Guillermina Lozano; Zhi-Min Yuan
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53.
The Journal of biological chemistry 2002;277(22):19251-4.
2002: Carolyn J Foster; Guillermina Lozano
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Oncogene 2002;21(22):3525-31.
2002: Jason D Grier; Wen Yan; Guillermina Lozano
Conditional allele of mdm2 which encodes a p53 inhibitor.
Genesis (New York, N.Y. : 2000) 2002;32(2):145-7.
2001: Mathias Schmidt; Ying Lu; John M Parant; Guillermina Lozano; G Bacher; Thomas Beckers; Zhen Fan
Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies.
Molecular pharmacology 2001;60(5):900-6.
2001: John M Parant; Arturo Chavez-Reyes; Natalie A Little; W Yan; V Reinke; Aart G Jochemsen; Guillermina Lozano
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Nature genetics 2001;29(1):92-5.
2001: Susan C Evans; M Viswanathan; Jason D Grier; M Narayana; Adel K El-Naggar; Guillermina Lozano
An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2.
Oncogene 2001;20(30):4041-9.
2001: John M Parant; V Reinke; B Mims; Guillermina Lozano
Organization, expression, and localization of the murine mdmx gene and pseudogene.
Gene 2001;270(1-2):277-83.
2001: Adel K El-Naggar; Syeling Lai; Gary L Clayman; B Mims; Scott M Lippman; Madelene M Coombes; M A Luna; Guillermina Lozano
p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas.
Carcinogenesis 2001;22(5):729-35.
2001: David M Keller; X Zeng; Yong Wang; Qinghong Zhang; M Kapoor; H Shu; Richard H Goodman; Guillermina Lozano; Y Zhao; Hua lu
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
Molecular cell 2001;7(2):283-92.
2001: Wendong Huang; S L Wang; Guillermina Lozano; Benoit de Crombrugghe
cDNA library screening using the SOS recruitment system.
BioTechniques 2001;30(1):94-8, 100.
2000: Geng Liu; Timothy J McDonnell; R Montes de Oca Luna; M Kapoor; B Mims; Adel K El-Naggar; Guillermina Lozano
High metastatic potential in mice inheriting a targeted p53 missense mutation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4174-9.
2000: S de Rozieres; R Maya; M Oren; Guillermina Lozano
The loss of mdm2 induces p53-mediated apoptosis.
Oncogene 2000;19(13):1691-7.
1999: Timothy J McDonnell; R Montes de Oca Luna; S Cho; Lisa L Amelse; Arturo Chavez-Reyes; Guillermina Lozano
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice.
The Journal of pathology 1999;188(3):322-8.
1999: Susan C Evans; Carolyn J Foster; Adel K El-Naggar; Guillermina Lozano
Mapping and mutational analysis of the human TAF2G gene encoding a p53 cofactor.
Genomics 1999;57(1):182-3.
1999: V Reinke; Donna M Bortner; Lisa L Amelse; K Lundgren; Michael P Rosenberg; C A Finlay; Guillermina Lozano
Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(3):147-54.
1999: Jaclyn Y Hung; B Mims; Guillermina Lozano; Louise C Strong; C Harvey; Tina T-L Chen; Victor Stastny; Gail Tomlinson
TP53 mutation and haplotype analysis of two large African American families.
Human mutation 1999;14(3):216-21.
1998: M Kapoor; R Montes de Oca Luna; Geng Liu; Guillermina Lozano; C Cummings; M Mancini; Ilia Ouspenski; B R Brinkley; Gregory S May
The cenpB gene is not essential in mice.
Chromosoma 1998;107(8):570-6.
1998: Susan C Evans; B Mims; K M McMasters; Carolyn J Foster; M deAndrade; Christopher I Amos; Louise C Strong; Guillermina Lozano
Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family.
Human genetics 1998;102(6):681-6.
1998: P Anaya; S C Evans; C Dai; Guillermina Lozano; Gregory S May
Isolation of the Aspergillus nidulans sudD gene and its human homologue.
Gene 1998;211(2):323-9.
1998: Guillermina Lozano; R Montes de Oca Luna
MDM2 function.
Biochimica et biophysica acta 1998;1377(2):M55-9.
1998: M Kapoor; Guillermina Lozano
Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2834-7.
1998: Zahid H Siddik; B Mims; Guillermina Lozano; G Thai
Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line.
Cancer research 1998;58(4):698-703.
1998: Guillermina Lozano; G Liu
Mouse models dissect the role of p53 in cancer and development.
Seminars in cancer biology 1998;8(5):337-44.
1997: AW Beham; MC Marin; A Fernandez; J Herrmann; Shawn Brisbay; Ana M Tari; Gabriel Lopez-Berestein; Guillermina Lozano; Mona Sarkiss; Timothy J McDonnell
Bcl-2 inhibits p53 nuclear import following DNA damage.
Oncogene 1997;15(23):2767-72.
1997: V Reinke; Guillermina Lozano
The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo.
Oncogene 1997;15(13):1527-34.
1997: Susan C Evans; Guillermina Lozano
The Li-Fraumeni syndrome: an inherited susceptibility to cancer.
Molecular medicine today 1997;3(9):390-5.
1997: V Reinke; Guillermina Lozano
Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest.
Radiation research 1997;148(2):115-22.
1997: R Montes de Oca Luna; Lisa L Amelse; Arturo Chavez-Reyes; S C Evans; James Brugarolas; T Jacks; Guillermina Lozano
Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality.
Nature genetics 1997;16(4):336-7.
1997: K Lundgren; R Montes de Oca Luna; Y B McNeill; E P Emerick; B Spencer; C R Barfield; Guillermina Lozano; Michael P Rosenberg; C A Finlay
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Genes & development 1997;11(6):714-25.
1997: Arnout C Ruifrok; Kathryn A Mason; Guillermina Lozano; Howard D Thames
Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment.
Radiation research 1997;147(1):1-12.
1996: M Hao; A M Lowy; M Kapoor; A Deffie; G Liu; Guillermina Lozano
Mutation of phosphoserine 389 affects p53 function in vivo.
The Journal of biological chemistry 1996;271(46):29380-5.
1996: K M McMasters; R Montes de Oca Luna; J R Peña; Guillermina Lozano
mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts.
Oncogene 1996;13(8):1731-6.
1996: R M de Oca Luna; A D Tabor; Heidi Eberspaecher; D L Hulboy; Laura L Worth; M S Colman; C A Finlay; Guillermina Lozano
The organization and expression of the mdm2 gene.
Genomics 1996;33(3):352-7.
1995: R Montes de Oca Luna; D S Wagner; Guillermina Lozano
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53.
Nature 1995;378(6553):203-6.
1995: A Deffie; M Hao; R Montes de Oca Luna; D L Hulboy; Guillermina Lozano
Cyclin E restores p53 activity in contact-inhibited cells.
Molecular and cellular biology 1995;15(7):3926-33.
1994: ZM Mu; K V Chin; J H Liu; Guillermina Lozano; Kun-Sang Chang
PML, a growth suppressor disrupted in acute promyelocytic leukemia.
Molecular and cellular biology 1994;14(10):6858-67.
1994: D L Hulboy; Guillermina Lozano
Structural and functional analysis of p53: the acidic activation domain has transforming capability.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(10):1023-31.
1994: H Wu; Guillermina Lozano
NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.
The Journal of biological chemistry 1994;269(31):20067-74.
1993: A Deffie; H Wu; V Reinke; Guillermina Lozano
The tumor suppressor p53 regulates its own transcription.
Molecular and cellular biology 1993;13(6):3415-23.
1993: M Hao; C A Finlay; Guillermina Lozano
A functionally inactive p53 Li-Fraumeni syndrome mutant.
Oncogene 1993;8(2):299-306.
1992: H Goldberg; T Helaakoski; Lee Ann Garrett-Sinha; Gerard Karsenty; A Pellegrino; Guillermina Lozano; SANKAR MAITY; Benoit de Crombrugghe
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.
The Journal of biological chemistry 1992;267(27):19622-30.
1992: L Raycroft; Guillermina Lozano
A convenient cloning vector containing the GAL4 DNA-binding domain.
Gene 1992;118(1):143-4.
1991: L Raycroft; J R Schmidt; K Yoas; M M Hao; Guillermina Lozano
Analysis of p53 mutants for transcriptional activity.
Molecular and cellular biology 1991;11(12):6067-74.
1991: Samuel W Beenken; Gerard Karsenty; L Raycroft; Guillermina Lozano
An intron binding protein is required for transformation ability of p53.
Nucleic acids research 1991;19(17):4747-52.
1990: L Raycroft; H Y Wu; Guillermina Lozano
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
Science (New York, N.Y.) 1990;249(4972):1049-51.
1990: Benoit de Crombrugghe; Gerard Karsenty; SANKAR MAITY; T Vuorio; P Rossi; E C Ruteshouser; S H McKinney; Guillermina Lozano
Transcriptional mechanisms controlling types I and III collagen genes.
Annals of the New York Academy of Sciences 1990;580():88-96.