Shelly Lu

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Varela-Rey Marta; Fernández-Ramos David; Martínez-López Nuria; Embade Nieves; Gómez-Santos Laura; Beraza Naiara; Vázquez-Chantada Mercedes; Rodríguez Juan; Luka Zigmund; Wagner Conrad; Lu Shelly C; Martínez-Chantar M Luz; Mato José M
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
Li Muyao; Chiu Jen-Fu; Kelsen Anne; Lu Shelly C; Fukagawa Naomi K
Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC).
Lu Shelly C; Ramani Komal; Ou Xiaopeng; Lin Mark; Yu Victor; Ko Kwangsuk; Park Ryan; Bottiglieri Teodoro; Tsukamoto Hidekazu; Kanel Gary; French Samuel W; Mato José M; Moats Rex; Grant Edward
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.

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2009: Varela-Rey Marta; Fernández-Ramos David; Martínez-López Nuria; Embade Nieves; Gómez-Santos Laura; Beraza Naiara; Vázquez-Chantada Mercedes; Rodríguez Juan; Luka Zigmund; Wagner Conrad; Lu Shelly C; Martínez-Chantar M Luz; Mato José M
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
Hepatology (Baltimore, Md.) 2009;50(2):443-52.
2009: Li Muyao; Chiu Jen-Fu; Kelsen Anne; Lu Shelly C; Fukagawa Naomi K
Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC).
Journal of cellular biochemistry 2009;107(5):944-54.
2009: Lu Shelly C; Ramani Komal; Ou Xiaopeng; Lin Mark; Yu Victor; Ko Kwangsuk; Park Ryan; Bottiglieri Teodoro; Tsukamoto Hidekazu; Kanel Gary; French Samuel W; Mato José M; Moats Rex; Grant Edward
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.
Hepatology (Baltimore, Md.) 2009;50(2):462-71.
2009: Li Tony W H; Zhang Qingsong; Oh Pilsoo; Xia Meng; Chen Hui; Bemanian Sean; Lastra Natalie; Circ Magda; Moyer Mary Pat; Mato José M; Aw Tak Yee; Lu Shelly C
S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.
Molecular pharmacology 2009;76(1):192-200.
2009: Yang Heping; Ramani Komal; Xia Meng; Ko Kwang Suk; Li Tony W H; Oh Pilsoo; Li Jiaping; Lu Shelly C
Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications.
Hepatology (Baltimore, Md.) 2009;49(6):1982-91.
2009: Varela-Rey Marta; Embade Nieves; Ariz Usue; Lu Shelly C; Mato José M; Martínez-Chantar M Luz
Non-alcoholic steatohepatitis and animal models: understanding the human disease.
The international journal of biochemistry & cell biology 2009;41(5):969-76.
2009: Ding Wei; Mouzaki Marialena; You Hanning; Laird Joshua C; Mato Jose; Lu Shelly C; Rountree C Bart
CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis.
Hepatology (Baltimore, Md.) 2009;49(4):1277-86.
2009: Oliva Joan; Bardag-Gorce Fawzia; Li Jun; French Barbara A; Nguyen Sheila K; Lu Shelly C; French Samuel W
Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms.
Experimental and molecular pathology 2009;86(2):77-86.
2009: Yang Heping; Li Tony W H; Ko Kwang Suk; Xia Meng; Lu Shelly C
Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes.
Hepatology (Baltimore, Md.) 2009;49(3):860-70.
2009: Tomasi Maria Lauda; Iglesias-Ara Ainhoa; Yang Heping; Ramani Komal; Feo Francesco; Pascale Maria Rosa; Martínez-Chantar M Luz; Mato José M; Lu Shelly C
S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.
Gastroenterology 2009;136(3):1025-36.
2009: Vázquez-Chantada Mercedes; Ariz Usue; Varela-Rey Marta; Embade Nieves; Martínez-Lopez Nuria; Fernández-Ramos David; Gómez-Santos Laura; Lamas Santiago; Lu Shelly C; Martínez-Chantar M Luz; Mato José M
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation.
Hepatology (Baltimore, Md.) 2009;49(2):608-17.
2009: Lu Shelly C
Regulation of glutathione synthesis.
Molecular aspects of medicine 2009;30(1-2):42-59.
2008: Conde-Vancells Javier; Rodriguez-Suarez Eva; Embade Nieves; Gil David; Matthiesen Rune; Valle Mikel; Elortza Felix; Lu Shelly C; Mato Jose M; Falcon-Perez Juan M
Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes.
Journal of proteome research 2008;7(12):5157-66.
2008: Lu Shelly C
Antioxidants in the treatment of chronic liver diseases: why is the efficacy evidence so weak in humans?
Hepatology (Baltimore, Md.) 2008;48(5):1359-61.
2008: Martínez-López Nuria; Varela-Rey Marta; Ariz Usue; Embade Nieves; Vazquez-Chantada Mercedes; Fernandez-Ramos David; Gomez-Santos Laura; Lu Shelly C; Mato Jose M; Martinez-Chantar Maria L
S-adenosylmethionine and proliferation: new pathways, new targets.
Biochemical Society transactions 2008;36(Pt 5):848-52.
2008: Ko Kwangsuk; Yang Heping; Noureddin Mazen; Iglesia-Ara Ainhoa; Xia Meng; Wagner Conrad; Luka Zigmund; Mato José M; Lu Shelly C
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.
Laboratory investigation; a journal of technical methods and pathology 2008;88(10):1121-9.
2008: Shukla Shivendra D; Velazquez Jose; French Samuel W; Lu Shelly C; Ticku Maharaj K; Zakhari Samir
Emerging role of epigenetics in the actions of alcohol.
Alcoholism, clinical and experimental research 2008;32(9):1525-34.
2008: Ara Ainhoa Iglesias; Xia Meng; Ramani Komal; Mato José M; Lu Shelly C
S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation.
Hepatology (Baltimore, Md.) 2008;47(5):1655-66.
2008: Fu Yumei; Zheng Shizhong; Lu Shelly C; Chen Anping
Epigallocatechin-3-gallate inhibits growth of activated hepatic stellate cells by enhancing the capacity of glutathione synthesis.
Molecular pharmacology 2008;73(5):1465-73.
2008: Martínez-Chantar M Luz; Vázquez-Chantada Mercedes; Ariz Usue; Martínez Nuria; Varela Marta; Luka Zigmund; Capdevila Antonieta; Rodríguez Juan; Aransay Ana M; Matthiesen Rune; Yang Heping; Calvisi Diego F; Esteller Manel; Fraga Mario; Lu Shelly C; Wagner Conrad; Mato José M
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
Hepatology (Baltimore, Md.) 2008;47(4):1191-9.
2008: Rountree C Bart; Senadheera Shantha; Mato Jose M; Crooks Gay M; Lu Shelly C
Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.
Hepatology (Baltimore, Md.) 2008;47(4):1288-97.
2008: Yu Mimi C; Yuan Jian-Min; Lu Shelly C
Alcohol, cofactors and the genetics of hepatocellular carcinoma.
Journal of gastroenterology and hepatology 2008;23 Suppl 1():S92-7.
2008: Lu Shelly C; Mato José M
S-Adenosylmethionine in cell growth, apoptosis and liver cancer.
Journal of gastroenterology and hepatology 2008;23 Suppl 1():S73-7.
2008: Ramani Komal; Yang Heping; Xia Meng; Ara Ainhoa Iglesias; Mato José M; Lu Shelly C
Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.
Hepatology (Baltimore, Md.) 2008;47(2):521-31.
2008: Yang Heping; Ara Ainhoa Iglesias; Magilnick Nathaniel; Xia Meng; Ramani Komal; Chen Hui; Lee Taunia D; Mato José M; Lu Shelly C
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.
Gastroenterology 2008;134(1):281-91.
2008: Yang Heping; Magilnick Nathaniel; Xia Meng; Lu Shelly C
Effects of hepatocyte growth factor on glutathione synthesis, growth, and apoptosis is cell density-dependent.
Experimental cell research 2008;314(2):398-412.
2008: Zhou Wenyun; Alonso Sergio; Takai Daisaku; Lu Shelly C; Yamamoto Fumiichiro; Perucho Manuel; Huang Shi
Requirement of RIZ1 for cancer prevention by methyl-balanced diet.
PloS one 2008;3(10):e3390.
2008: Mato José M; Martínez-Chantar M Luz; Lu Shelly C
Methionine metabolism and liver disease.
Annual review of nutrition 2008;28():273-93.
2007: Yuan Jian-Min; Lu Shelly C; Van Den Berg David; Govindarajan Sugantha; Zhang Zhen-Quan; Mato Jose M; Yu Mimi C
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2007;46(3):749-58.
2007: Chen Hui; Xia Meng; Lin Mark; Yang Heping; Kuhlenkamp John; Li Tony; Sodir Nicole M; Chen Yong-Heng; Josef-Lenz Heinz; Laird Peter W; Clarke Steven; Mato José M; Lu Shelly C
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.
Gastroenterology 2007;133(1):207-18.
2007: Purohit Vishnudutt; Abdelmalek Manal F; Barve Shirish; Benevenga Norlin J; Halsted Charles H; Kaplowitz Neil; Kharbanda Kusum K; Liu Qi-Ying; Lu Shelly C; McClain Craig J; Swanson Christine; Zakhari Samir
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
The American journal of clinical nutrition 2007;86(1):14-24.
2007: Mato José M; Lu Shelly C
Role of S-adenosyl-L-methionine in liver health and injury.
Hepatology (Baltimore, Md.) 2007;45(5):1306-12.
2007: Rubio Angel; Guruceaga Elizabeth; Vázquez-Chantada Mercedes; Sandoval Juan; Martínez-Cruz L Alfonso; Segura Victor; Sevilla José L; Podhorski Adam; Corrales Fernando J; Torres Luis; Rodríguez Manuel; Aillet Fabienne; Ariz Usue; Arrieta Felix Martínez; Caballería Juan; Martín-Duce Antonio; Lu Shelly C; Martínez-Chantar M Luz; Mato José M
Identification of a gene-pathway associated with non-alcoholic steatohepatitis.
Journal of hepatology 2007;46(4):708-18.
2007: Yang Heping; Magilnick Nathaniel; Noureddin Mazen; Mato José M; Lu Shelly C
Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells.
Journal of cellular physiology 2007;210(3):766-73.
2007: Ou Xiaopeng; Yang Heping; Ramani Komal; Ara Ainhoa Iglesias; Chen Hui; Mato José M; Lu Shelly C
Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine.
The Biochemical journal 2007;401(1):87-96.
2006: Lu Shelly C; Martínez-Chantar M Luz; Mato José M
Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S61-4.
2006: Martínez-Chantar María L; Vázquez-Chantada Mercedes; Garnacho Marta; Latasa M Ujue; Varela-Rey Marta; Dotor Javier; Santamaria Monica; Martínez-Cruz Luis A; Parada Luis A; Lu Shelly C; Mato José M
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Gastroenterology 2006;131(1):223-32.
2006: Prudova Anna; Bauman Zachary; Braun Aaron; Vitvitsky Victor; Lu Shelly C; Banerjee Ruma
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6489-94.
2006: Santamaría Enrique; Muñoz Javier; Fernandez-Irigoyen Joaquín; Sesma Laura; Mora María I; Berasain Carmen; Lu Shelly C; Mato José M; Prieto Jesús; Avila Matías A; Corrales Fernando J
Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases.
Journal of proteome research 2006;5(4):944-53.
2005: Fernández-Irigoyen Jokin; Santamaría Enrique; Sesma Laura; Muñoz Javier; Riezu José Ignacio; Caballería Juan; Lu Shelly C; Prieto Jesús; Mato José M; Avila Matías A; Corrales Fernando J
Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis.
Proteomics 2005;5(18):4964-72.
2005: Yang Heping; Magilnick Nathaniel; Ou Xiaopeng; Lu Shelly C
Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1.
The Biochemical journal 2005;391(Pt 2):399-408.
2005: Lee Taunia D; Yang Heping; Whang Janet; Lu Shelly C
Cloning and characterization of the human glutathione synthetase 5'-flanking region.
The Biochemical journal 2005;390(Pt 2):521-8.
2005: Yang Heping; Magilnick Nathaniel; Lee Candy; Kalmaz Denise; Ou Xiaopeng; Chan Jefferson Y; Lu Shelly C
Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
Molecular and cellular biology 2005;25(14):5933-46.
2005: Mato José M; Lu Shelly C
Homocysteine, the bad thiol.
Hepatology (Baltimore, Md.) 2005;41(5):976-9.
2005: Lu Shelly C; Mato José M
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
Alcohol (Fayetteville, N.Y.) 2005;35(3):227-34.
2005: Zhou Qin; Ji Xuhuai; Chen Lixin; Greenberg Harry B; Lu Shelly C; Omary M Bishr
Keratin mutation primes mouse liver to oxidative injury.
Hepatology (Baltimore, Md.) 2005;41(3):517-25.
2004: Avila Matías A; García-Trevijano Elena R; Lu Shelly C; Corrales Fernando J; Mato José M
Methylthioadenosine.
The international journal of biochemistry & cell biology 2004;36(11):2125-30.
2004: Lim So-Young; Jang Jung-Hee; Na Hye-Kyung; Lu Shelly C; Rahman Irfan; Surh Young-Joon
15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis.
The Journal of biological chemistry 2004;279(44):46263-70.
2004: Yang Heping; Sadda Mamatha R; Li Mei; Zeng Ying; Chen Lixin; Bae Wanjun; Ou Xiaopeng; Runnegar Maria T; Mato José M; Lu Shelly C
S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).
Hepatology (Baltimore, Md.) 2004;40(1):221-31.
2004: Chen Lixin; Zeng Ying; Yang Heping; Lee Taunia D; French Samuel W; Corrales Fernando J; García-Trevijano Elena R; Avila Matías A; Mato José M; Lu Shelly C
Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):914-6.
2004: Hevia Henar; Varela-Rey Marta; Corrales Fernando J; Berasain Carmen; Martínez-Chantar María L; Latasa M Ujue; Lu Shelly C; Mato José M; García-Trevijano Elena R; Avila Matías A
5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.
Hepatology (Baltimore, Md.) 2004;39(4):1088-98.
2004: Wu Yong; Zhang Xiaoxue; Bardag-Gorce Fawzia; Robel Rose C V; Aguilo Jonathan; Chen Lixin; Zeng Ying; Hwang Kelly; French Samuel W; Lu Shelly C; Wan Yu-Jui Y
Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver.
Molecular pharmacology 2004;65(3):550-7.
2004: Lee Taunia D; Sadda Mamatha R; Mendler Michel H; Bottiglieri Teodoro; Kanel Gary; Mato José M; Lu Shelly C
Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis.
Alcoholism, clinical and experimental research 2004;28(1):173-81.
2003: Dai Tiane; Wu Yong; Leng Ai-She; Ao Yan; Robel Rose C V; Lu Shelly C; French Samuel W; Wan Yu-Jui Y
RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity.
Experimental and molecular pathology 2003;75(3):194-200.
2003: Yang Heping; Sadda Mamatha R; Yu Victor; Zeng Ying; Lee Taunia D; Ou Xiaopeng; Chen Lixin; Lu Shelly C
Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1.
The Journal of biological chemistry 2003;278(51):50887-96.
2003: Martínez-Chantar Maria L; Latasa M Ujue; Varela-Rey Marta; Lu Shelly C; García-Trevijano Elena R; Mato José M; Avila Matías A
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.
The Journal of biological chemistry 2003;278(22):19885-90.
2003: Santamaria Enrique; Avila Matías A; Latasa M Ujue; Rubio Angel; Martin-Duce Antonio; Lu Shelly C; Mato José M; Corrales Fernando J
Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3065-70.
2003: Lu Shelly C; Gukovsky Ilya; Lugea Aurelia; Reyes Christopher N; Huang Zong-Zhi; Chen Lixin; Mato José M; Bottiglieri Teodoro; Pandol Stephen J
Role of S-adenosylmethionine in two experimental models of pancreatitis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):56-8.
2002: Yang Heping; Zeng Ying; Lee Taunia D; Yang Yang; Ou Xiaopeng; Chen Lixin; Haque Masudul; Rippe Richard; Lu Shelly C
Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone.
The Journal of biological chemistry 2002;277(38):35232-9.
2002: Martínez-Chantar Maria L; Corrales Fernando J; Martínez-Cruz L Alfonso; García-Trevijano Elena R; Huang Zong-Zhi; Chen Lixin; Kanel Gary; Avila Matías A; Mato José M; Lu Shelly C
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1292-4.
2002: Lu Shelly C; Tsukamoto Hidekazu; Mato José M
Role of abnormal methionine metabolism in alcoholic liver injury.
Alcohol (Fayetteville, N.Y.) 2002;27(3):155-62.
2002: Ansorena Eduardo; García-Trevijano Elena R; Martínez-Chantar Maria L; Huang Zong-Zhi; Chen Lixin; Mato José M; Iraburu Maria; Lu Shelly C; Avila Matías A
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.
Hepatology (Baltimore, Md.) 2002;35(2):274-80.
2002: Mato Jose M; Corrales Fernando J; Lu Shelly C; Avila Matias A
S-Adenosylmethionine: a control switch that regulates liver function.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(1):15-26.
2001: Yang H; Wang J; Ou X; Huang Z Z; Lu S C
Cloning and analysis of the rat glutamate-cysteine ligase modifier subunit promoter.
Biochemical and biophysical research communications 2001;285(2):476-82.
2001: Yang H; Wang J; Huang Z Z; Ou X; Lu S C
Cloning and characterization of the 5'-flanking region of the rat glutamate-cysteine ligase catalytic subunit.
The Biochemical journal 2001;357(Pt 2):447-55.
2001: Yang H; Huang Z Z; Wang J; Lu S C
The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1507-16.
2001: Tsukamoto H; Lu S C
Current concepts in the pathogenesis of alcoholic liver injury.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1335-49.
2001: Latasa M U; Boukaba A; García-Trevijano E R; Torres L; Rodríguez J L; Caballería J; Lu S C; López-Rodas G; Franco L; Mato J M; Avila M A
Hepatocyte growth factor induces MAT2A expression and histone acetylation in rat hepatocytes: role in liver regeneration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(7):1248-50.
2001: Lu S C; Alvarez L; Huang Z Z; Chen L; An W; Corrales F J; Avila M A; Kanel G; Mato J M
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5560-5.
2001: Yang H; Huang Z Z; Zeng Z; Chen C; Selby R R; Lu S C
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(2):G184-90.
2001: Zeng Z; Yang H; Huang Z Z; Chen C; Wang J; Lu S C
The role of c-Myb in the up-regulation of methionine adenosyltransferase 2A expression in activated Jurkat cells.
The Biochemical journal 2001;353(Pt 1):163-168.
2001: Huang Z Z; Chen C; Zeng Z; Yang H; Oh J; Chen L; Lu S C
Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):19-21.
2000: Avila M A; Berasain C; Torres L; Martín-Duce A; Corrales F J; Yang H; Prieto J; Lu S C; Caballería J; Rodés J; Mato J M
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
Journal of hepatology 2000;33(6):907-14.
2000: Huang Z A; Yang H; Chen C; Zeng Z; Lu S C
Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression.
Biochimica et biophysica acta 2000;1493(1-2):48-55.
2000: Lu S C; Huang Z Z; Yang H; Mato J M; Avila M A; Tsukamoto H
Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G178-85.
2000: Lu S C
S-Adenosylmethionine.
The international journal of biochemistry & cell biology 2000;32(4):391-5.
2000: Zeng Z; Huang Z Z; Chen C; Yang H; Mao Z; Lu S C
Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 1A gene.
The Biochemical journal 2000;346 Pt 2():475-82.
2000: Torres L; Avila M A; Carretero M V; Latasa M U; Caballería J; López-Rodas G; Boukaba A; Lu S C; Franco L; Mato J M
Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(1):95-102.
2000: Lu S C
Regulation of glutathione synthesis.
Current topics in cellular regulation 2000;36():95-116.
1999: Lu S C; Huang Z Z; Yang H; Tsukamoto H
Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat.
Toxicology and applied pharmacology 1999;159(3):161-8.
1999: Lu S C; Bao Y; Huang Z Z; Sarthy V P; Kannan R
Regulation of gamma-glutamylcysteine synthetase subunit gene expression in retinal Müller cells by oxidative stress.
Investigative ophthalmology & visual science 1999;40(8):1776-82.
1999: Lu S C; Huang Z Z; Yang J M; Tsukamoto H
Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat.
Hepatology (Baltimore, Md.) 1999;30(1):209-14.
1999: Lu S C
Regulation of hepatic glutathione synthesis: current concepts and controversies.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(10):1169-83.
1999: Huang Z Z; Mato J M; Kanel G; Lu S C
Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat.
Hepatology (Baltimore, Md.) 1999;29(5):1471-8.
1998: Mao Z; Liu S; Cai J; Huang Z Z; Lu S C
Cloning and functional characterization of the 5'-flanking region of human methionine adenosyltransferase 2A gene.
Biochemical and biophysical research communications 1998;248(3):479-84.
1998: Huang Z Z; Mao Z; Cai J; Lu S C
Changes in methionine adenosyltransferase during liver regeneration in the rat.
The American journal of physiology 1998;275(1 Pt 1):G14-21.
1998: Cai J; Mao Z; Hwang J J; Lu S C
Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells.
Cancer research 1998;58(7):1444-50.
1998: Huang Z Z; Li H; Cai J; Kuhlenkamp J; Kaplowitz N; Lu S C
Changes in glutathione homeostasis during liver regeneration in the rat.
Hepatology (Baltimore, Md.) 1998;27(1):147-53.
1998: Lu S C
Regulation of hepatic glutathione synthesis.
Seminars in liver disease 1998;18(4):331-43.
1997: Cai J; Huang Z Z; Lu S C
Differential regulation of gamma-glutamylcysteine synthetase heavy and light subunit gene expression.
The Biochemical journal 1997;326 ( Pt 1)():167-72.
1997: Lu S C; Kuhlenkamp J; Wu H; Sun W M; Stone L; Kaplowitz N
Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats.
The American journal of physiology 1997;272(2 Pt 1):G374-82.
1996: Sun W M; Huang Z Z; Lu S C
Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation.
The Biochemical journal 1996;320 ( Pt 1)():321-8.
1996: Cai J; Sun W M; Hwang J J; Stain S C; Lu S C
Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.
Hepatology (Baltimore, Md.) 1996;24(5):1090-7.
1996: Lu S C; Cai J; Kuhlenkamp J; Sun W M; Takikawa H; Takenaka O; Horie T; Yi J; Kaplowitz N
Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats.
Hepatology (Baltimore, Md.) 1996;24(1):253-8.
1996: Lu S C; Sun W M; Yi J; Ookhtens M; Sze G; Kaplowitz N
Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells.
The Journal of clinical investigation 1996;97(6):1488-96.
1995: Lu S C; Sun W M; Nagineni C N; Hooks J J; Kannan R
Bidirectional glutathione transport by cultured human retinal pigment epithelial cells.
Investigative ophthalmology & visual science 1995;36(12):2523-30.
1995: Cai J; Sun W M; Lu S C
Hormonal and cell density regulation of hepatic gamma-glutamylcysteine synthetase gene expression.
Molecular pharmacology 1995;48(2):212-8.
1995: Runnegar M T; Kong S M; Zhong Y Z; Lu S C
Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes.
Biochemical pharmacology 1995;49(2):219-25.
1994: Lu S C; Kuhlenkamp J; Ge J L; Sun W M; Kaplowitz N
Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver.
Molecular pharmacology 1994;46(3):578-85.
1994: Runnegar M T; Kong S M; Zhong Y Z; Ge J L; Lu S C
The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes.
Biochemical and biophysical research communications 1994;201(1):235-41.
1994: Lu S C; Huang H Y
Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes.
Biochemical pharmacology 1994;47(5):859-69.
1993: Sze G; Kaplowitz N; Ookhtens M; Lu S C
Bidirectional membrane transport of intact glutathione in Hep G2 cells.
The American journal of physiology 1993;265(6 Pt 1):G1128-34.
1993: Lu S C; Ge J L; Huang H Y; Kuhlenkamp J; Kaplowitz N
Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers.
The Journal of clinical investigation 1993;92(3):1188-97.
1992: Lu S C; Ge J L
Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes.
The American journal of physiology 1992;263(6 Pt 1):C1181-9.
1992: Lu S C; Ge J L; Kuhlenkamp J; Kaplowitz N
Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.
The Journal of clinical investigation 1992;90(2):524-32.
1991: Lu S C; Kuhlenkamp J; Garcia-Ruiz C; Kaplowitz N
Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat.
The Journal of clinical investigation 1991;88(1):260-9.
1990: Lu S C; Garcia-Ruiz C; Kuhlenkamp J; Ookhtens M; Salas-Prato M; Kaplowitz N
Hormonal regulation of glutathione efflux.
The Journal of biological chemistry 1990;265(27):16088-95.
1989: Lu S C; Kuhlenkamp J; Robert A; Kaplowitz N
Role of glutathione status in protection against ethanol-induced gastric lesions.
Pharmacology 1989;38(1):57-60.

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