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Wuyuan Lu

Research Profile

Chemicals & Drugs

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TOP 3
Amar A Patil; Wuyuan Lu; Andre J Ouellette; Guolong Zhang
Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities.
Marzena Pazgier; Edvin Pozharskiy; Jishu Shi; Eric A Toth; Weirong Yuan; Changyou Zhan; Guozhang Zou; Bryan Ericksen; Amy Galliher-Beckley; Liqiong Lan; Xiangdong Li; Minhua Ling; Wuyuan Lu
Structural and functional analysis of the pro-domain of human cathelicidin, LL-37.
Lusine H Demirkhanyan; Maikha Jean-Baptiste; Wuyuan Lu; Mariana Marin; Kosuke Miyauchi; Gennadiy Novitskiy; Sergi Padilla-Parra; Changyou Zhan; Gregory B Melikyan
Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin.

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All Publications

2013: Amar A Patil; Wuyuan Lu; Andre J Ouellette; Guolong Zhang
Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities.
Antimicrobial agents and chemotherapy 2013;57(4):1823-31.
2013: Marzena Pazgier; Edvin Pozharskiy; Jishu Shi; Eric A Toth; Weirong Yuan; Changyou Zhan; Guozhang Zou; Bryan Ericksen; Amy Galliher-Beckley; Liqiong Lan; Xiangdong Li; Minhua Ling; Wuyuan Lu
Structural and functional analysis of the pro-domain of human cathelicidin, LL-37.
Biochemistry 2013;52(9):1547-58.
2012: Lusine H Demirkhanyan; Maikha Jean-Baptiste; Wuyuan Lu; Mariana Marin; Kosuke Miyauchi; Gennadiy Novitskiy; Sergi Padilla-Parra; Changyou Zhan; Gregory B Melikyan
Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin.
The Journal of biological chemistry 2012;287(34):28821-38.
2012: Hiutung Chu; Maarten F de Jong; Grace Jung; Robert I Lehrer; Wuyuan Lu; Sean-Paul Nuccio; Marzena Pazgier; Nita H Salzman; Bo Shen; Renée M Tsolis; Mark A Underwood; Jan Wehkamp; Maria G Winter; Sebastian E Winter; Glenn M Young; Andreas J Baumler; Patricia A Castillo; Charles L Bevins
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Science (New York, N.Y.) 2012;337(6093):477-81.
2012: Anshu P Gounder; Wuyuan Lu; Mayim E Wiens; Sarah S Wilson; Jason G Smith
Critical determinants of human α-defensin 5 activity against non-enveloped viruses.
The Journal of biological chemistry 2012;287(29):24554-62.
2012: Changyou Zhan; Le Zhao; Xishan Chen; Wei-Yue Lu; Marzena Pazgier; Xiaoli Wei; Xueji Wu; Weirong Yuan; Wuyuan Lu
An ultrahigh affinity d-peptide antagonist Of MDM2.
Journal of medicinal chemistry 2012;55(13):6237-41.
2012: Mohsen Rajabi; Xueji Wu; Le Zhao; Erik de Leeuw; Bryan Ericksen; Marzena Pazgier; Wuyuan Lu
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.
The Journal of biological chemistry 2012;287(26):21615-27.
2012: Le Zhao; Bryan Ericksen; Xu Li; Marzena Pazgier; Xueji Wu; Weirong Yuan; Changyou Zhan; Wuyuan Lu
Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1.
The Journal of biological chemistry 2012;287(23):18900-12.
2012: Changyou Zhan; Le Zhao; Kristen M Varney; Weirong Yuan; Wuyuan Lu
Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined.
Journal of the American Chemical Society 2012;134(15):6855-64.
2012: Fiorenza Cocchi; Anthony DeVico; Massimo Galli; Alfredo Garzino-Demo; Mark K Lafferty; Olga Latinovic; Wuyuan Lu; Mikulas Popovic; Robert R Redfield; Mohammad M Sajadi; Robert C Gallo
Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNases.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5411-6.
2012: Marzena Pazgier; Henryk Szmacinski; Gang Wei; Zhibin Wu; Weirong Yuan; Erik de Leeuw; Bryan Ericksen; Grace Jung; Robert I Lehrer; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.
The Journal of biological chemistry 2012;287(12):8944-53.
2012: Robert I Lehrer; Wuyuan Lu
α-Defensins in human innate immunity.
Immunological reviews 2012;245(1):84-112.
2011: Eusondia Arnett; Robert I Lehrer; Pratikhya Pratikhya; Wuyuan Lu; Stéphanie Seveau
Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes.
Cellular microbiology 2011;13(4):635-51.
2011: Aprille Rapista; Bernadette Benito; Jian Ding; Yung-Tai Lo; Wuyuan Lu; Matthew B Neiditch; Theresa L Chang
Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment.
Retrovirology 2011;8():45.
2011: Changyou Zhan; Wuyuan Lu
Peptide activators of the p53 tumor suppressor.
Current pharmaceutical design 2011;17(6):603-9.
2011: Jian Ding; Aprille Rapista; Natalia Teleshova; Wuyuan Lu; Mary E Klotman; Theresa L Chang
Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides.
Journal of innate immunity 2011;3(2):208-12.
2010: Yuan Zhang; Wuyuan Lu; Mei Hong
The membrane-bound structure and topology of a human α-defensin indicate a dimer pore mechanism for membrane disruption.
Biochemistry 2010;49(45):9770-82.
2010: Tinoush Moulaei; Olga Stuchlik; Matthew Reed; Weirong Yuan; Jan Pohl; Wuyuan Lu; Lauren Haugh-Krumpe; Barry R O'Keefe; Alexander Wlodawer
Topology of the disulfide bonds in the antiviral lectin scytovirin.
Protein science : a publication of the Protein Society 2010;19(9):1649-61.
2010: Min Liu; Changqing Li; Marzena Pazgier; Changqing Li; Yubin Mao; Yifan Lv; Bing Gu; Gang Wei; Weirong Yuan; Changyou Zhan; Wei-Yue Lu; Wuyuan Lu
D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14321-6.
2010: Changqing Li; Marzena Pazgier; Jing Li; Changqing Li; Min Liu; Guozhang Zou; Zhenyu Li; Jiandong Chen; Sergey G Tarasov; Wei-Yue Lu; Wuyuan Lu
Limitations of peptide retro-inverso isomerization in molecular mimicry.
The Journal of biological chemistry 2010;285(25):19572-81.
2010: Gang Wei; Marzena Pazgier; Erik de Leeuw; Mohsen Rajabi; Jing Li; Guozhang Zou; Grace Jung; Weirong Yuan; Wei-Yue Lu; Robert I Lehrer; Wuyuan Lu
Trp-26 imparts functional versatility to human alpha-defensin HNP1.
The Journal of biological chemistry 2010;285(21):16275-85.
2010: Min Liu; Marzena Pazgier; Changqing Li; Weirong Yuan; Chong Li; Wuyuan Lu
A left-handed solution to peptide inhibition of the p53-MDM2 interaction.
Angewandte Chemie (International ed. in English) 2010;49(21):3649-52.
2010: Changqing Li; Marzena Pazgier; Changqing Li; Weirong Yuan; Min Liu; Gang Wei; Wei-Yue Lu; Wuyuan Lu
Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions.
Journal of molecular biology 2010;398(2):200-13.
2010: Erik de Leeuw; Changqing Li; Pengyun Zeng; Changqing Li; Marlies Diepeveen-de Buin; Wuyuan Lu; Eefjan Breukink; Wuyuan Lu
Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II.
FEBS letters 2010;584(8):1543-8.
2010: Yuan Zhang; Tim Doherty; Jing Li; Wuyuan Lu; Cyril Barinka; Jacek Lubkowski; Mei Hong
Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR.
Journal of molecular biology 2010;397(2):408-22.
2010: Mark K Lafferty; Lingling Sun; Leon DeMasi; Wuyuan Lu; Alfredo Garzino-Demo
CCR6 ligands inhibit HIV by inducing APOBEC3G.
Blood 2010;115(8):1564-71.
2010: Changqing Li; Xiangqun Li; Wuyuan Lu
Total chemical synthesis of human T-cell leukemia virus type 1 protease via native chemical ligation.
Biopolymers 2010;94(4):487-94.
2010: Jason G Smith; Mariena Silvestry; Steffen Lindert; Wuyuan Lu; Glen R Nemerow; Phoebe L Stewart
Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization.
PLoS pathogens 2010;6(6):e1000959.
2010: Song Li; Luisa Bozzo; Zhibin Wu; Wuyuan Lu; Fabio Romerio
The HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells.
The new microbiologica 2010;33(1):13-24.
2009: Gang Wei; Erik de Leeuw; Marzena Pazgier; Weirong Yuan; Guozhang Zou; Jianfeng Wang; Bryan Ericksen; Wei-Yue Lu; Robert I Lehrer; Wuyuan Lu
Through the looking glass, mechanistic insights from enantiomeric human defensins.
The Journal of biological chemistry 2009;284(42):29180-92.
2009: Robert I Lehrer; Grace Jung; Piotr Ruchala; Wei Wang; Ewa D Micewicz; Alan J Waring; Eugene J Gillespie; Kenneth A Bradley; Adam J Ratner; Richard F Rest; Wuyuan Lu
Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.
Infection and immunity 2009;77(9):4028-40.
2009: Erik de Leeuw; Mohsen Rajabi; Guozhang Zou; Marzena Pazgier; Wuyuan Lu
Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5.
FEBS letters 2009;583(15):2507-12.
2009: Katherine Miles; David J Clarke; Wuyuan Lu; Zaneta Sibinska; Paula E Beaumont; Donald J Davidson; Tom Barr; Dominic J Campopiano; Mohini Gray
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):2122-32.
2009: Robert I Lehrer; Grace Jung; Piotr Ruchala; Sabine Andre; Hans J Gabius; Wuyuan Lu
Multivalent binding of carbohydrates by the human alpha-defensin, HD5.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):480-90.
2009: Marzena Pazgier; Min Liu; Guozhang Zou; Weirong Yuan; Changqing Li; Chong Li; Jing Li; Juahdi Monbo; Davide Zella; Sergey G Tarasov; Wuyuan Lu
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4665-70.
2009: Chong Li; Marzena Pazgier; Min Liu; Wei-Yue Lu; Wuyuan Lu
Apamin as a template for structure-based rational design of potent peptide activators of p53.
Angewandte Chemie (International ed. in English) 2009;48(46):8712-5.
2008: Ioannis Gryllos; Jessica Tran-Winkler; Ming-Fang Cheng; Hachung Chung; Robert Bolcome; Wuyuan Lu; Robert I Lehrer; Michael R Wessels
Induction of group A Streptococcus virulence by a human antimicrobial peptide.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16755-60.
2008: Changqing Li; Min Liu; Juahdi Monbo; Guozhang Zou; Changqing Li; Weirong Yuan; Davide Zella; Wei-Yue Lu; Wuyuan Lu
Turning a scorpion toxin into an antitumor miniprotein.
Journal of the American Chemical Society 2008;130(41):13546-8.
2008: Suming Wang; Jinbo Han; Yanfang Wang; Wuyuan Lu; Chengwu Chi
Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2.
Acta biochimica et biophysica Sinica 2008;40(10):848-54.
2008: Guozhang Zou; Erik de Leeuw; Jacek Lubkowski; Wuyuan Lu
Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.
Journal of molecular biology 2008;381(5):1281-91.
2008: Changqing Li; Zhibin Wu; Min Liu; Marzena Pazgier; Wuyuan Lu
Chemically synthesized human survivin does not inhibit caspase-3.
Protein science : a publication of the Protein Society 2008;17(9):1624-9.
2008: Mohsen Rajabi; Erik de Leeuw; Marzena Pazgier; Jing Li; Jacek Lubkowski; Wuyuan Lu
The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability.
The Journal of biological chemistry 2008;283(31):21509-18.
2008: Mary E Klotman; Aprille Rapista; Natalia Teleshova; Amanda Micsenyi; Gary Jarvis; Wuyuan Lu; Edith Porter; Theresa L Chang
Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6176-85.
2007: Jamil S Saad; Andrew Kim; Ruba H Ghanam; Amanda K Dalton; Volker M Vogt; Zhibin Wu; Wuyuan Lu; Michael F Summers
Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch.
Protein science : a publication of the Protein Society 2007;16(8):1793-7.
2007: Jishu Shi; Shelly Aono; Wuyuan Lu; Andre J Ouellette; Xueyou Hu; Yingbiao Ji; Lei Wang; Stephen D Lenz; Frederik W van Ginkel; Mark Liles; Christine Dykstra; Edward E Morrison; Charles O Elson
A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1245-53.
2007: Guozhang Zou; Erik de Leeuw; Chong Li; Marzena Pazgier; Changqing Li; Pengyun Zeng; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
The Journal of biological chemistry 2007;282(27):19653-65.
2007: Zhibin Wu; Xiangqun Li; Bryan Ericksen; Erik de Leeuw; Guozhang Zou; Pengyun Zeng; Cao Xie; Chong Li; Jacek Lubkowski; Wei-Yue Lu; Wuyuan Lu
Impact of pro segments on the folding and function of human neutrophil alpha-defensins.
Journal of molecular biology 2007;368(2):537-49.
2007: Erik de Leeuw; Wuyuan Lu
Human defensins: turning defense into offense?
Infectious disorders drug targets 2007;7(1):67-70.
2007: Xiangqun Li; Guozhang Zou; Weirong Yuan; Wuyuan Lu
Defining the native disulfide topology in the somatomedin B domain of human vitronectin.
The Journal of biological chemistry 2007;282(8):5318-26.
2007: Erik de Leeuw; Scott Burks; Xiangqun Li; Joseph Kao; Wuyuan Lu
Structure-dependent functional properties of human defensin 5.
FEBS letters 2007;581(3):515-20.
2007: Marzena Pazgier; Xiangqun Li; Wuyuan Lu; Jacek Lubkowski
Human defensins: synthesis and structural properties.
Current pharmaceutical design 2007;13(30):3096-118.
2006: Ehsan Hazrati; Benjamin Galen; Wuyuan Lu; Wei Wang; Yan Ouyang; Marla Keller; Robert I Lehrer; Betsy C Herold
Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8658-66.
2006: Agnieszka Szyk; Zhibin Wu; Kenneth Tucker; De Yang; Wuyuan Lu; Jacek Lubkowski
Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Protein science : a publication of the Protein Society 2006;15(12):2749-60.
2006: Jean K Lim; Wuyuan Lu; Oliver Hartley; Anthony DeVico
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.
Journal of leukocyte biology 2006;80(6):1395-404.
2006: Wei Wang; Chandrika Mulakala; Sabrina C Ward; Grace Jung; Hai Luong; Duy Pham; Alan J Waring; Yiannis N Kaznessis; Wuyuan Lu; Kenneth A Bradley; Robert I Lehrer
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.
The Journal of biological chemistry 2006;281(43):32755-64.
2006: Shelly Aono; Changqing Li; Guolong Zhang; Robert J Kemppainen; Julie A Gard; Wuyuan Lu; Xueyou Hu; Dean D Schwartz; Edward E Morrison; Christine Dykstra; Jishu Shi
Molecular and functional characterization of bovine beta-defensin-1.
Veterinary immunology and immunopathology 2006;113(1-2):181-90.
2006: Erik de Leeuw; Xiangqun Li; Wuyuan Lu
Binding characteristics of the Lactobacillus brevis ATCC 8287 surface layer to extracellular matrix proteins.
FEMS microbiology letters 2006;260(2):210-5.
2006: Marzena Pazgier; David M Hoover; De Yang; Wuyuan Lu; Jacek Lubkowski
Human beta-defensins.
Cellular and molecular life sciences : CMLS 2006;63(11):1294-313.
2006: ZhengPing Yi; Olga Vitek; MA Qasim; Stephen M Lu; Wuyuan Lu; Michael Ranjbar; Jiangtian Li; Michael C Laskowski; Chris Bailey-Kellogg; Michael Laskowski
Functional evolution within a protein superfamily.
Proteins 2006;63(3):697-708.
2006: Tina Kish-Catalone; Wuyuan Lu; Robert C Gallo; Anthony DeVico
Preclinical evaluation of synthetic -2 RANTES as a candidate vaginal microbicide to target CCR5.
Antimicrobial agents and chemotherapy 2006;50(4):1497-509.
2006: Christopher B Buck; Patricia M Day; Cynthia D Thompson; Jacek Lubkowski; Wuyuan Lu; Douglas Lowy; John T Schiller
Human alpha-defensins block papillomavirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1516-21.
2006: Cheng-Zhong Wang; Hua Zhang; Hui Jiang; Wuyuan Lu; Zhi-Qi Zhao; Cheng-Wu Chi
A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels.
Toxicon : official journal of the International Society on Toxinology 2006;47(1):122-32.
2005: Zhibin Wu; Xiangqun Li; Erik de Leeuw; Bryan Ericksen; Wuyuan Lu
Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?
The Journal of biological chemistry 2005;280(52):43039-47.
2005: Matina Economopoulou; Khalil Bdeir; Douglas B Cines; Franz Fogt; Yasmina Bdeir; Jacek Lubkowski; Wuyuan Lu; Klaus T Preissner; Hans-Peter Hammes; Triantafyllos Chavakis
Inhibition of pathologic retinal neovascularization by alpha-defensins.
Blood 2005;106(12):3831-8.
2005: Cao Xie; Pengyun Zeng; Bryan Ericksen; Zhibin Wu; Wei-Yue Lu; Wuyuan Lu
Effects of the terminal charges in human neutrophil alpha-defensin 2 on its bactericidal and membrane activity.
Peptides 2005;26(12):2377-83.
2005: Minnie John; Marla Keller; Ehsan H Fam; Natalia Cheshenko; Kathleen Hogarty; Andrea Kasowitz; Sylvan Wallenstein; Maria Josefina Carlucci; Ana C Tuyama; Wuyuan Lu; Mary E Klotman; Robert I Lehrer; Betsy C Herold
Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection.
The Journal of infectious diseases 2005;192(10):1731-40.
2005: Xiangqun Li; Erik de Leeuw; Wuyuan Lu
Total chemical synthesis of human psoriasin by native chemical ligation.
Biochemistry 2005;44(44):14688-94.
2005: Lingling Sun; Catherine M Finnegan; Tina Kish-Catalone; Robert Blumenthal; Paolo Garzino-Demo; Gian M La Terra Maggiore; Sid Berrone; Carol Kleinman; Zhibin Wu; Sayed F Abdelwahab; Wuyuan Lu; Alfredo Garzino-Demo
Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection.
Journal of virology 2005;79(22):14318-29.
2005: Cao Xie; Adam Prahl; Bryan Ericksen; Zhibin Wu; Pengyun Zeng; Xiangqun Li; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
The Journal of biological chemistry 2005;280(38):32921-9.
2005: Jean K Lim; Jennifer M Burns; Wuyuan Lu; Anthony DeVico
Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5.
Journal of leukocyte biology 2005;78(2):442-52.
2005: Chun-Guang Wang; Zheng Cai; Wuyuan Lu; Jihui Wu; Yingqi Xu; Yunyu Shi; Cheng-Wu Chi
A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi Karsch, sequencing, gene cloning and structure determination.
Toxicon : official journal of the International Society on Toxinology 2005;45(3):309-19.
2005: Zhibin Wu; Fiorenza Cocchi; David Gentles; Bryan Ericksen; Jacek Lubkowski; Anthony DeVico; Robert I Lehrer; Wuyuan Lu
Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.
FEBS letters 2005;579(1):162-6.
2005: Bryan Ericksen; Zhibin Wu; Wuyuan Lu; Robert I Lehrer
Antibacterial activity and specificity of the six human {alpha}-defensins.
Antimicrobial agents and chemotherapy 2005;49(1):269-75.
2004: Zhibin Wu; Bryan Ericksen; K Tucker; Jacek Lubkowski; Wuyuan Lu
Synthesis and characterization of human alpha-defensins 4-6.
The journal of peptide research : official journal of the American Peptide Society 2004;64(3):118-25.
2004: Chen-Qi Xu; Bert Brône; Dieter Wicher; Ozlem Bozkurt; Wuyuan Lu; Isabelle Huys; Yu-Hong Han; Jan Tytgat; Emmy Van Kerkhove; Cheng-Wu Chi
BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch.
The Journal of biological chemistry 2004;279(33):34562-9.
2004: Zhibin Wu; Jerry Alexandratos; Bryan Ericksen; Jacek Lubkowski; Robert C Gallo; Wuyuan Lu
Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11587-92.
2004: Zheng Cai; Chenqi Xu; Yingqi Xu; Wuyuan Lu; Cheng-wu Chi; Yunyu Shi; Jihui Wu
Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch.
Biochemistry 2004;43(13):3764-71.
2004: Agnieszka Szyk; Wuyuan Lu; Chenqi Xu; Jacek Lubkowski
Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur.
Journal of structural biology 2004;145(3):289-94.
2003: David M Hoover; Zhibin Wu; Kenneth Tucker; Wuyuan Lu; Jacek Lubkowski
Antimicrobial characterization of human beta-defensin 3 derivatives.
Antimicrobial agents and chemotherapy 2003;47(9):2804-9.
2003: Zhibin Wu; Adam Prahl; Robert Powell; Bryan Ericksen; Jacek Lubkowski; Wuyuan Lu
From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain.
The journal of peptide research : official journal of the American Peptide Society 2003;62(2):53-62.
2003: Zhibin Wu; David M Hoover; De Yang; Cyril Boulegue; Fanny Santamaria; Joost J Oppenheim; Jacek Lubkowski; Wuyuan Lu
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8880-5.
2003: Oluwatoyin A Asojo; Cyril Boulegue; David M Hoover; Wuyuan Lu; Jacek Lubkowski
Structures of thymus and activation-regulated chemokine (TARC).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1165-73.
2003: MA Qasim; Wuyuan Lu; Stephen M Lu; Michael Ranjbar; ZhengPing Yi; Yi-Wen Chiang; Kevin Ryan; Stephen Anderson; Wenlei Zhang; Sabiha Qasim; Michael Laskowski
Testing of the additivity-based protein sequence to reactivity algorithm.
Biochemistry 2003;42(21):6460-6.
2003: Gabor Pal; Fanny Santamaria; Anthony A Kossiakoff; Wuyuan Lu
The first semi-synthetic serine protease made by native chemical ligation.
Protein expression and purification 2003;29(2):185-92.
2003: Fanny Santamaria; Zhibin Wu; Cyril Boulegue; Gabor Pal; Wuyuan Lu
Reexamination of the recognition preference of the specificity pocket of the Abl SH3 domain.
Journal of molecular recognition : JMR 2003;16(3):131-8.
2003: Zhibin Wu; Robert Powell; Wuyuan Lu
Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide.
Journal of the American Chemical Society 2003;125(9):2402-3.
2003: Oluwatoyin A Asojo; Simon Cater; David M Hoover; Cyril Boulegue; Wuyuan Lu; Jacek Lubkowski
Crystallization and preliminary X-ray studies of thymus and activation-regulated chemokine (TARC).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):163-5.
2002: David M Hoover; Cyril Boulegue; De Yang; Joost J Oppenheim; Kenneth Tucker; Wuyuan Lu; Jacek Lubkowski
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
The Journal of biological chemistry 2002;277(40):37647-54.
2001: Zdenek Hel; Wen-Po Tsai; A Thornton; Janos Nacsa; Laura Giuliani; Elzbieta Tryniszewska; M Poudyal; David Venzon; X Wang; John D Altman; David Ian Watkins; Wuyuan Lu; Agneta S von Gegerfelt; Barbara K Felber; Jim Tartaglia; George Pavlakis; Genoveffa Franchini
Potentiation of simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7180-91.
2001: Istvan Botos; Zhibin Wu; Wuyuan Lu; Alexander Wlodawer
Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.
FEBS letters 2001;509(1):90-4.
2001: Stephen M Lu; Wuyuan Lu; MA Qasim; Stephen Anderson; I Apostol; W Ardelt; T Bigler; Yi-Wen Chiang; J Cook; Michael N G James; I Kato; C Kelly; W Kohr; T Komiyama; T Y Lin; M Ogawa; J Otlewski; S J Park; Sabiha Qasim; Michael Ranjbar; M Tashiro; Nicholas Warne; H Whatley; A Wieczorek; M Wieczorek; T Wilusz; R Wynn; Wei Zhang; Michael Laskowski
Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1410-5.
2001: KS Bateman; K Huang; S Anderson; Wuyuan Lu; MA Qasim; Michael Laskowski; Michael N G James
Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi[CH2NH2+]-Asp19I.
Journal of molecular biology 2001;305(4):839-49.
2000: W Y Lu; M A Starovasnik; JJ Dwyer; Anthony A Kossiakoff; Stephen B H Kent; Wuyuan Lu
Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis.
Biochemistry 2000;39(13):3575-84.
2000: Mary Dwyer; Wuyuan Lu; JJ Dwyer; Anthony A Kossiakoff
Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity.
Chemistry & biology 2000;7(4):263-74.
2000: KS Bateman; S Anderson; Wuyuan Lu; MA Qasim; Michael Laskowski; Michael N G James
Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB.
Protein science : a publication of the Protein Society 2000;9(1):83-94.
1999: Wuyuan Lu; M Randal; Anthony A Kossiakoff; Stephen B H Kent
Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes.
Chemistry & biology 1999;6(7):419-27.
1998: Wuyuan Lu; M A Starovasnik; Stephen B H Kent
Total chemical synthesis of bovine pancreatic trypsin inhibitor by native chemical ligation.
FEBS letters 1998;429(1):31-5.
1998: ZQ Shi; Wuyuan Lu; Gen-Sheng Feng
The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(9):4904-8.
1997: M J Luo; Wuyuan Lu; C W Chi
Clarification of an uncertain intron within the cDNA sequences of arrowhead proteinase inhibitors A and B.
Journal of biochemistry 1997;121(5):991-5.
1997: Wuyuan Lu; I Apostol; MA Qasim; Nicholas Warne; R Wynn; W L Zhang; Stephen Anderson; Yi-Wen Chiang; E Ogin; I Rothberg; K Ryan; Michael Laskowski
Binding of amino acid side-chains to S1 cavities of serine proteinases.
Journal of molecular biology 1997;266(2):441-61.
1997: Wuyuan Lu; MA Qasim; Michael Laskowski; S B Kent
Probing intermolecular main chain hydrogen bonding in serine proteinase-protein inhibitor complexes: chemical synthesis of backbone-engineered turkey ovomucoid third domain.
Biochemistry 1997;36(4):673-9.
1995: K Huang; Wuyuan Lu; S Anderson; Michael Laskowski; Michael N G James
Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.
Protein science : a publication of the Protein Society 1995;4(10):1985-97.
1993: Wuyuan Lu; W Zhang; S S Molloy; Gary Thomas; K Ryan; Y Chiang; Stephen Anderson; Michael Laskowski
Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin.
The Journal of biological chemistry 1993;268(20):14583-5.
1993: T L Bigler; Wuyuan Lu; S J Park; M Tashiro; M Wieczorek; R Wynn; Michael Laskowski
Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues.
Protein science : a publication of the Protein Society 1993;2(5):786-99.
1990: Michael Laskowski; I Apostol; Wojciech Ardelt; J Cook; A Giletto; C A Kelly; Wuyuan Lu; S J Park; MA Qasim; H E Whatley
Amino acid sequences of ovomucoid third domain from 25 additional species of birds.
Journal of protein chemistry 1990;9(6):715-25.