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Zhimin Lu

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Yanhua Zheng; Zhimin Lu
Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST).
Weiwei Yang; M James You; Lin Zhang; Yanhua Zheng; Inder M Verma; Yan Xia; Kenneth Aldape; Wen Bu; Yu Cao; Paul J Chiao; Gilbert Cote; Mei Yee Koh; Yi Li; Zhimin Lu
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

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All Publications

2013: Yanhua Zheng; Zhimin Lu
Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST).
Chinese journal of cancer 2013;32(2):75-83.
2012: Weiwei Yang; M James You; Lin Zhang; Yanhua Zheng; Inder M Verma; Yan Xia; Kenneth Aldape; Wen Bu; Yu Cao; Paul J Chiao; Gilbert Cote; Mei Yee Koh; Yi Li; Zhimin Lu
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Molecular cell 2012;48(5):771-84.
2012: Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Nature cell biology 2012;14(12):1295-304.
2012: Weiwei Yang; Yan Xia; Dongming Xing; Kenneth Aldape; W K Alfred Yung; David Hawke; Tony Hunter; Xinjian Li; Ji Liang; Zhimin Lu
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
Cell 2012;150(4):685-96.
2012: Haitao Ji; Bing-Hua Jiang; Zhiyong Ding; David Hawke; Gordon B Mills; Dongming Xing; Zhimin Lu
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.
EMBO reports 2012;13(6):554-60.
2011: Weiwei Yang; Yanhua Zheng; Yan Xia; Kenneth Aldape; Xiang Gao; Wenhua Huang; Haitao Ji; Ji Liang; Zhimin Lu
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
Nature 2011;480(7375):118-22.
2011: Yanhua Zheng; David Hawke; David X Liu; Yan Xia; Weiwei Yang; Zhimin Lu
Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.
Molecular and cellular biology 2011;31(21):4258-69.
2011: Wen-Tai Chiu; Cheng-Yang Chou; Feng-Ju Huang; Hsueh-Te Lee; Zhimin Lu; Patricia S Steeg; Keping Xie; Jun Yao; Kenneth Aldape; Suyun Huang
Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.
Cancer research 2011;71(14):4932-43.
2011: Haitao Ji; Bingliang Fang; Xuexun Fang; Ji Wang; Zhimin Lu
α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation.
Journal of neuro-oncology 2011;103(3):445-51.
2010: Zhimin Lu; Tony Hunter
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors.
Cell cycle (Georgetown, Tex.) 2010;9(12):2342-52.
2010: Zhiyong Ding; Jiyong Liang; Jin Li; Yiling Lu; Vathsala Ariyaratna; Zhimin Lu; Michael A Davies; John K Westwick; Gordon B Mills
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
PloS one 2010;5(3):e9910.
2009: haitao ji; Ji Wang; Heinz Nika; David Hawke; Susan Keezer; Qingyuan Ge; Bingliang Fang; Xuexun Fang; Dexing Fang; David W Litchfield; Kenneth Aldape; Zhimin Lu
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.
Molecular cell 2009;36(4):547-59.
2009: Yanhua Zheng; Zhimin Lu
Paradoxical roles of FAK in tumor cell migration and metastasis.
Cell cycle (Georgetown, Tex.) 2009;8(21):3474-9.
2009: Yanhua Zheng; Yan Xia; David Hawke; Maxime Halle; Michel L Tremblay; Xiang Gao; Xiao Zhen Zhou; Kenneth Aldape; Melanie H Cobb; Keping Xie; Jie He; Zhimin Lu
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Molecular cell 2009;35(1):11-25.
2009: Hehua Chen; Yan Xia; Dexing Fang; David Hawke; Zhimin Lu
Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis.
Molecular and cellular biology 2009;29(13):3657-64.
2008: Shuying Liu; Xianjun Fang; Hassan Hall; Shuangxing Yu; Debra Smith; Zhimin Lu; Dexing Fang; Jinsong Liu; L Clifton Stephens; James R Woodgett; Gordon B Mills
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5248-53.
2007: Dexing Fang; David Hawke; Yanhua Zheng; Yan Xia; Jill Meisenhelder; Heinz Nika; Gordon B Mills; Ryuji Kobayashi; Tony Hunter; Zhimin Lu
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.
The Journal of biological chemistry 2007;282(15):11221-9.
2007: Yan Xia; Ji Wang; Ta-Jen Liu; W K Alfred Yung; Tony Hunter; Zhimin Lu
c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.
Molecular cell 2007;25(2):219-32.
2007: Yan Xia; Ji Wang; Shuichan Xu; Gary L Johnson; Tony Hunter; Zhimin Lu
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.
Molecular and cellular biology 2007;27(2):510-7.
2006: Zhimin Lu; Shuichan Xu
ERK1/2 MAP kinases in cell survival and apoptosis.
IUBMB life 2006;58(11):621-31.
2004: Zhimin Lu; Tony Hunter
Wnt-independent beta-catenin transactivation in tumor development.
Cell cycle (Georgetown, Tex.) 2004;3(5):571-3.

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