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Jian'an Luan

Research Profile

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Physiology

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Publications

TOP 3
Ulf Ekelund; Dale W Esliger; Pippa Griew; Jian'an Luan; Lauren B Sherar; Ashley Cooper
Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents.
Shengxu Li; J H Zhao; Jian'an Luan; C Langenberg; Robert N Luben; Kay-Tee Khaw; Nicholas J Wareham; Ruth J F Loos
Genetic predisposition to obesity leads to increased risk of type 2 diabetes.
Elizabeth C Cottrell; Malgorzata S Martin-Gronert; Denise S Fernandez-Twinn; Jian'an Luan; Lindsey M Berends; Susan E Ozanne
Leptin-independent programming of adult body weight and adiposity in mice.

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All Publications

2012: Ulf Ekelund; Dale W Esliger; Pippa Griew; Jian'an Luan; Lauren B Sherar; Ashley Cooper
Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents.
JAMA : the journal of the American Medical Association 2012;307(7):704-12.
2011: Shengxu Li; J H Zhao; Jian'an Luan; C Langenberg; Robert N Luben; Kay-Tee Khaw; Nicholas J Wareham; Ruth J F Loos
Genetic predisposition to obesity leads to increased risk of type 2 diabetes.
Diabetologia 2011;54(4):776-82.
2011: Elizabeth C Cottrell; Malgorzata S Martin-Gronert; Denise S Fernandez-Twinn; Jian'an Luan; Lindsey M Berends; Susan E Ozanne
Leptin-independent programming of adult body weight and adiposity in mice.
Endocrinology 2011;152(2):476-82.
2010: Denise S Fernandez-Twinn; Sofia Ekizoglou; Malgorzata S Martin-Gronert; J Tarry-Adkins; A P Wayman; M J Warner; Jian'an Luan; barry gusterson; Susan E Ozanne
Poor early growth and excessive adult calorie intake independently and additively affect mitogenic signaling and increase mammary tumor susceptibility.
Carcinogenesis 2010;31(10):1873-81.
2010: Shengxu Li; Jing Hua Zhao; Jian'an Luan; Ulf Ekelund; Robert N Luben; Kay-Tee Khaw; Nicholas J Wareham; Ruth J F Loos
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
PLoS medicine 2010;7(8):.
2010: Shengxu Li; Jing Hua Zhao; Jian'an Luan; Robert N Luben; Sheila A Rodwell; Kay-Tee Khaw; Ken K Ong; Nicholas J Wareham; Ruth J F Loos
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.
The American journal of clinical nutrition 2010;91(1):184-90.
2009: F M Finucane; Jian'an Luan; Nicholas J Wareham; S J Sharp; S O'Rahilly; B Balkau; A Flyvbjerg; M Walker; K Højlund; J J Nolan; David B Savage
Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.
Diabetologia 2009;52(11):2345-9.
2009: Karani S Vimaleswaran; Shengxu Li; Jing Hua Zhao; Jian'an Luan; Sheila A Bingham; Kay-Tee Khaw; Ulf Ekelund; Nicholas J Wareham; Ruth J F Loos
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.
The American journal of clinical nutrition 2009;90(2):425-8.
2009: Jian'an Luan; Berit Kerner; Jing-Hua Zhao; Ruth Jf Loos; Stephen J Sharp; Bengt Muthén; Nicholas J Wareham
A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.
BMC proceedings 2009;3 Suppl 7():S115.
2009: Ulf Ekelund; Sigmund A Anderssen; Lars Bo Andersen; Chris Riddoch; Luis B Sardinha; Jian'an Luan; Karsten Froberg; Søren Brage
Prevalence and correlates of the metabolic syndrome in a population-based sample of European youth.
The American journal of clinical nutrition 2009;89(1):90-6.
2008: Inês Barroso; Jian'an Luan; Eleanor Wheeler; Pamela Whittaker; Jon Wasson; Eleftheria Zeggini; Michael N Weedon; Sarah Hunt; Ranganath Venkatesh; Timothy M Frayling; Marcos Delgado; Rosalind J Neuman; Jinghua Zhao; Richard Sherva; Benjamin Glaser; Mark Walker; Graham A Hitman; Mark I McCarthy; Andrew T Hattersley; M Alan Permutt; Nicholas J Wareham; Panos Deloukas
Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
Diabetes 2008;57(11):3161-5.
2008: Nita G Forouhi; Jian'an Luan; Andrew Cooper; Barbara J Boucher; Nicholas J Wareham
Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000.
Diabetes 2008;57(10):2619-25.
2007: Robert K Semple; Nils H Halberg; Keith Burling; Maria A Soos; Todd D Schraw; Jian'an Luan; Elaine Cochran; David D Dunger; Nicholas J Wareham; Philipp E Scherer; Phillip Gorden; Stephen O'Rahilly
Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies.
Diabetes 2007;56(6):1712-7.
2007: Karen Tan; Wendy Kimber; Jian'an Luan; Maria A Soos; Robert K Semple; Nicholas J Wareham; Stephen O'Rahilly; Inês Barroso
Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes.
Diabetes 2007;56(3):714-9.
2007: S C Collins; Jian'an Luan; A J Thompson; Allan Daly; Robert K Semple; Stephen O'Rahilly; Nicholas J Wareham; Inês Barroso
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Diabetologia 2007;50(3):555-62.
2007: Paul W Franks; Ulf Ekelund; Søren Brage; Jian'an Luan; Alan J Schafer; Stephen O'Rahilly; Inês Barroso; Nicholas J Wareham
PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge.
Diabetologia 2007;50(3):569-73.
2007: Denise S Fernandez-Twinn; Sofia Ekizoglou; barry gusterson; Jian'an Luan; Susan E Ozanne
Compensatory mammary growth following protein restriction during pregnancy and lactation increases early-onset mammary tumor incidence in rats.
Carcinogenesis 2007;28(3):545-52.
2007: C-C C Hung; Jian'an Luan; M Sims; Julia M Keogh; C Hall; Nicholas J Wareham; Stephen O'Rahilly; I Sadaf Farooqi
Studies of the SIM1 gene in relation to human obesity and obesity-related traits.
International journal of obesity (2005) 2007;31(3):429-34.
2006: K A Fawcett; Nicholas J Wareham; Jian'an Luan; H Syddall; C Cooper; Stephen O'Rahilly; I N M Day; Manjinder S Sandhu; Inês Barroso
PARL Leu262Val is not associated with fasting insulin levels in UK populations.
Diabetologia 2006;49(11):2649-52.
2006: Anne-Helen Harding; R J F Loos; Jian'an Luan; Stephen O'Rahilly; Nicholas J Wareham; Inês Barroso
Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes.
Diabetologia 2006;49(11):2642-8.
2006: Maura Agostini; Erik Schoenmakers; Catherine Mitchell; Istvan Szatmari; David Savage; Aaron Smith; Odelia Rajanayagam; Robert K Semple; Jian'an Luan; Louise Bath; Anthony Zalin; Mourad Labib; Sudhesh Kumar; Helen Simpson; Dirk Blom; David Marais; John W R Schwabe; Inês Barroso; Richard C Trembath; Nicholas J Wareham; Laszlo Nagy; Mark Gurnell; Stephen O'Rahilly; Krishna Chatterjee
Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.
Cell metabolism 2006;4(4):303-11.
2006: Robert K Semple; Maria A Soos; Jian'an Luan; C S Mitchell; J C Wilson; Mark Gurnell; Elaine Cochran; Phillip Gorden; V Krishna K Chatterjee; Nicholas J Wareham; Stephen O'Rahilly
Elevated plasma adiponectin in humans with genetically defective insulin receptors.
The Journal of clinical endocrinology and metabolism 2006;91(8):3219-23.
2006: Sumit Bhattacharyya; Jian'an Luan; Benjamin G Challis; Julia Keogh; Montague Carl; John Brennand; John Morten; Sarah Lowenbeim; Suzanne Jenkins; I Sadaf Farooqi; Nicholas J Wareham; Stephen O'Rahilly
Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.
Journal of lipid research 2006;47(4):761-6.
2006: Inês Barroso; Jian'an Luan; Manjinder S Sandhu; Paul W Franks; Vivion E F Crowley; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.
Diabetologia 2006;49(3):501-5.
2006: Søren Brage; Niels Brage; Ulf Ekelund; Jian'an Luan; Paul W Franks; Karsten Froberg; Nicholas J Wareham
Effect of combined movement and heart rate monitor placement on physical activity estimates during treadmill locomotion and free-living.
European journal of applied physiology 2006;96(5):517-24.
2005: Manjinder S Sandhu; Barbara Heude; Elizabeth H Young; Robert Luben; Jian'an Luan; Kay-Tee Khaw; John Todd; Nicholas J Wareham
INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women.
Diabetes 2005;54(9):2812-5.
2005: Paul W Franks; Jian'an Luan; Inês Barroso; Søren Brage; Jose Luis Gonzalez Sanchez; Ulf Ekelund; Manuel Serrano Ríos; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance.
Diabetes 2005;54(9):2795-801.
2005: Paul W Franks; Søren Brage; Jian'an Luan; Ulf Ekelund; Mushtaquar Rahman; I Sadaf Farooqi; Ian Halsall; Stephen O'Rahilly; Nicholas J Wareham
Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.
Obesity research 2005;13(8):1476-84.
2004: Sumit Bhattacharyya; Jian'an Luan; I Sadaf Farooqi; Julia Keogh; Montague Carl; John Brennand; Lynn Jorde; Nicholas J Wareham; Stephen O'Rahilly
Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.
The Journal of endocrinology 2004;183(1):115-20.
2004: Chiao-Chien Connie Hung; Fraser Pirie; Jian'an Luan; Emma Lank; Ayesha Motala; Giles S H Yeo; Julia M Keogh; Nicholas J Wareham; Stephen O'Rahilly; I Sadaf Farooqi
Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.
Diabetes 2004;53(9):2461-6.
2004: William T Gibson; Pavlos Pissios; Daniel Trombly; Jian'an Luan; Julia Keogh; Nicholas J Wareham; Eleftheria Maratos-Flier; Stephen O'Rahilly; I Sadaf Farooqi
Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.
Obesity research 2004;12(5):743-9.
2004: Man-Yu Wong; Nicholas E Day; Jian'an Luan; Nicholas J Wareham
Estimation of magnitude in gene-environment interactions in the presence of measurement error.
Statistics in medicine 2004;23(6):987-98.
2004: Matthias Laudes; Inês Barroso; Jian'an Luan; Maria A Soos; Giles Yeo; Aline Meirhaeghe; Lisa Logie; Antonio Vidal-Puig; Alan J Schafer; Nicholas J Wareham; Stephen O'Rahilly
Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes.
Diabetes 2004;53(3):842-6.
2004: Benjamin G Challis; Jian'an Luan; Julia Keogh; Nicholas J Wareham; I Sadaf Farooqi; Stephen O'Rahilly
Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(3):442-6.
2004: Paul W Franks; Sumit Bhattacharyya; Jian'an Luan; Montague Carl; John Brennand; Benjamin G Challis; Søren Brage; Ulf Ekelund; Rita P S Middelberg; Stephen O'Rahilly; Nicholas J Wareham
Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10.
Hypertension 2004;43(2):224-8.
2004: David A J Neal; Brian D M Tom; Jian'an Luan; Nicholas J Wareham; Alexander E S Gimson; Luc Delriviere; Christopher D Byrne; Graeme J M Alexander
Is there disparity between risk and incidence of cardiovascular disease after liver transplant?
Transplantation 2004;77(1):93-9.
2004: Paul W Franks; Jian'an Luan; P O Browne; Anne-Helen Harding; Stephen O'Rahilly; V Krishna K Chatterjee; Nicholas J Wareham
Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
Metabolism: clinical and experimental 2004;53(1):11-6.
2003: Paul W Franks; Inês Barroso; Jian'an Luan; Ulf Ekelund; Vivion E F Crowley; Søren Brage; Manjinder S Sandhu; Rupert W Jakes; Rita P S Middelberg; Anne-Helen Harding; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max.
Medicine and science in sports and exercise 2003;35(12):1998-2004.
2003: Inês Barroso; Jian'an Luan; Rita P S Middelberg; Anne-Helen Harding; Paul W Franks; Rupert W Jakes; D Clayton; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.
PLoS biology 2003;1(1):E20.
2003: Paul W Franks; I Sadaf Farooqi; Jian'an Luan; Man-Yu Wong; Ian Halsall; Stephen O'Rahilly; Nicholas J Wareham
Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition?
The Journal of clinical endocrinology and metabolism 2003;88(7):3258-63.
2003: Sumit Bhattacharyya; Jian'an Luan; Benjamin G Challis; Catherine Schmitz; Paul Clarkson; Paul W Franks; Rita P S Middelberg; Julia Keogh; I Sadaf Farooqi; Montague Carl; John Brennand; Nicholas J Wareham; Stephen O'Rahilly
Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.
Diabetes 2003;52(5):1296-9.
2003: Chiao-Chien Connie Hung; I Sadaf Farooqi; Ken Ong; Jian'an Luan; Julia M Keogh; Marcus E Pembrey; Giles S H Yeo; David D Dunger; Nicholas J Wareham; Stephen O' Rahilly
Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations.
Diabetes 2003;52(5):1288-91.
2003: Man-Yu Wong; Nicholas E Day; Jian'an Luan; K P Chan; Nicholas J Wareham
The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement?
International journal of epidemiology 2003;32(1):51-7.
2002: Paul W Franks; Man-Yu Wong; Jian'an Luan; Jo Mitchell; Susie Hennings; Nicholas J Wareham
Non-esterified fatty acid levels and physical inactivity: the relative importance of low habitual energy expenditure and cardio-respiratory fitness.
The British journal of nutrition 2002;88(3):307-13.
2002: Benjamin G Challis; Lynn E Pritchard; John W M Creemers; Jerome Delplanque; Julia M Keogh; Jian'an Luan; Nicholas J Wareham; Giles S H Yeo; Sumit Bhattacharyya; philippe froguel; Anne White; I Sadaf Farooqi; Stephen O'Rahilly
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
Human molecular genetics 2002;11(17):1997-2004.
2002: David B Savage; Maura Agostini; Inês Barroso; Mark Gurnell; Jian'an Luan; Aline Meirhaeghe; Anne-Helen Harding; Gudrun Ihrke; Odelia Rajanayagam; Maria A Soos; Stella George; Dirk Berger; E Louise Thomas; Jimmy D Bell; Karim Meeran; R J M Ross; Antonio Vidal-Puig; Nicholas J Wareham; Stephen O'Rahilly; V Krishna K Chatterjee; Alan J Schafer
Digenic inheritance of severe insulin resistance in a human pedigree.
Nature genetics 2002;31(4):379-84.
2001: Aline Meirhaeghe; Jian'an Luan; P Selberg-Franks; Susie Hennings; Jo Mitchell; Halsall David; Stephen O'Rahilly; Nicholas J Wareham
The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity.
The Journal of clinical endocrinology and metabolism 2001;86(12):5881-7.
2001: Jian'an Luan; Man-Yu Wong; Nicholas E Day; Nicholas J Wareham
Sample size determination for studies of gene-environment interaction.
International journal of epidemiology 2001;30(5):1035-40.
2001: Halsall David; Jian'an Luan; P Saker; S Huxtable; I Sadaf Farooqi; Julia Keogh; Nicholas J Wareham; Stephen O'Rahilly
Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(4):472-7.
2001: Jian'an Luan; P O Browne; Anne-Helen Harding; Halsall David; Stephen O'Rahilly; V Krishna K Chatterjee; Nicholas J Wareham
Evidence for gene-nutrient interaction at the PPARgamma locus.
Diabetes 2001;50(3):686-9.
2000: Benjamin G Challis; Giles S H Yeo; I Sadaf Farooqi; Jian'an Luan; S Aminian; Halsall David; Julia M Keogh; Nicholas J Wareham; Stephen O'Rahilly
The CART gene and human obesity: mutational analysis and population genetics.
Diabetes 2000;49(5):872-5.