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Ronald Lubet

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Ronald A Lubet; Holly L Nicastro; Vernon E Steele; Eva Szabo; Chris Tucker; Ann Bode; Stanley C Gill; Kenneth K Iwata; M Margaret Juliana; Clinton J Grubbs
Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis.
Jixia Li; Ronald A Lubet; Nicola Normanno; Feng Zhu; Amelia D'Alessio; Antonella De Luca; Zigang Dong; Marna E Ericson; Clinton Grubbs; Ann M Bode
Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis.
Hua Xie; Feng Zhu; Dong Joon Kim; Ann M Bode; Jian Ding; Soouk Kang; Mee-Hyun Lee; Haitao Li; Xiang Li; Yan Li; Do Young Lim; Ronald A Lubet; Weiya Ma; Cong Peng; Kanamata Reddy; Zigang Dong
Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.

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2013: Ronald A Lubet; Holly L Nicastro; Vernon E Steele; Eva Szabo; Chris Tucker; Ann Bode; Stanley C Gill; Kenneth K Iwata; M Margaret Juliana; Clinton J Grubbs
Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis.
Cancer prevention research (Philadelphia, Pa.) 2013;6(5):448-54.
2013: Jixia Li; Ronald A Lubet; Nicola Normanno; Feng Zhu; Amelia D'Alessio; Antonella De Luca; Zigang Dong; Marna E Ericson; Clinton Grubbs; Ann M Bode
Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis.
Molecular carcinogenesis 2013;52(2):134-43.
2013: Hua Xie; Feng Zhu; Dong Joon Kim; Ann M Bode; Jian Ding; Soouk Kang; Mee-Hyun Lee; Haitao Li; Xiang Li; Yan Li; Do Young Lim; Ronald A Lubet; Weiya Ma; Cong Peng; Kanamata Reddy; Zigang Dong
Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.
Cancer research 2013;73(2):716-24.
2013: Yian Wang; Weidong Wen; Ruisheng Yao; Yinqiu Du; Song Gao; Ming Hu; Ronald A Lubet; Eva Szabo; Ming You
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.
Molecular carcinogenesis 2013;52(1):49-56.
2012: Xiang Li; Yan Li; Ronald A Lubet; Weiya Ma; Janos Nadas; Naomi Oi; Lei Wang; Hua Xie; Dong Hoon Yu; Feng Zhu; Tatyana A Zykova; Dong Joon Kim; Myoung Ok Kim; Mee-Hyun Lee; Haitao Li; Shengqing Li; Ann M Bode; Ziming Dong; Zigang Dong
Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B.
Carcinogenesis 2012;33(12):2548-57.
2012: Michael A Pereira; Vernon E Steele; Blake M Warner; Christopher M Weghorst; Thomas J Knobloch; Ronald A Lubet; Bruce C Casto
Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.
International journal of cancer. Journal international du cancer 2012;131(6):1277-86.
2012: Naomi Oi; Myoung Ok Kim; Ann M Bode; Hanyong Chen; Ronald A Lubet; Zigang Dong
Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K.
Cancer prevention research (Philadelphia, Pa.) 2012;5(9):1103-14.
2012: Hua Xie; Feng Zhu; Ann M Bode; Zunnan Huang; Sung Keun Jung; Soouk Kang; Dong Joon Kim; Mee-Hyun Lee; Haitao Li; Xiang Li; Do Young Lim; Ronald A Lubet; Weiya Ma; Kanamata Reddy; Lei Wang; Zigang Dong
Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo.
Carcinogenesis 2012;33(9):1814-21.
2012: Qi Zhang; Ronald A Lubet; Paula E North; Jing Pan; Yian Wang; Shoua Yang; Ming You
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.
Cancer prevention research (Philadelphia, Pa.) 2012;5(5):717-25.
2012: Ronald A Lubet; David L McCormick; Michael A Pereira; Vernon E Steele; W-C L Chang; Margie L Clapper; Susan M Fischer; M Margaret Juliana; Clinton J Grubbs
Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers.
Oncology reports 2012;27(5):1400-6.
2012: Yan Lu; Ronald A Lubet; Francoise Van den Bergh; Weidong Wen; Clinton J Grubbs; Michael James; Pengyuan Liu; Victoria Zellmer; Ming You
Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer.
Cancer prevention research (Philadelphia, Pa.) 2012;5(2):248-59.
2012: Hanyong Chen; Ann M Bode; Haitao Li; Ronald A Lubet; Margarita Malakhova; Janos Nadas; Naomi Oi; Ke Yao; Zigang Dong
Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods.
PloS one 2012;7(5):e38261.
2012: Erick Román-Pérez; Keith Amos; Lisa A Carey; Patricia Casbas-Hernández; Ronald A Lubet; Sendurai Mani; Jason R Pirone; Jessica Rein; Melissa A Troester
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients.
Breast cancer research : BCR 2012;14(2):R51.
2011: Huijing Fu; Yan Lu; Ronald A Lubet; Jing Pan; Eva Szabo; Yian Wang; Weidong Wen; Da-Ren Chen; Ruth Chen; Jingjie Zhang; Qi Zhang; Ming You
Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice.
Molecular carcinogenesis 2011;50(12):913-21.
2011: Yan Li; Ronald A Lubet; Weiya Ma; Ann M Bode; Dong Joon Kim; Zigang Dong
Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures.
Journal of chemical information and modeling 2011;51(11):2904-14.
2011: Dong Joon Kim; Jong-Eun Kim; Myoung Ok Kim; Yan Li; Ronald A Lubet; Janos Nadas; Kanamata Reddy; Jung-Hyun Shim; Nu Ry Song; Ann M Bode; Andria Carper; Yong-Yeon Cho; Zigang Dong
(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.
Cancer prevention research (Philadelphia, Pa.) 2011;4(11):1842-51.
2011: Susan M Fischer; Ernest T Hawk; Ronald A Lubet
Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention.
Cancer prevention research (Philadelphia, Pa.) 2011;4(11):1728-35.
2011: Ronald A Lubet; Vernon E Steele; James A Crowell; Silvio L De Flora; Brandy M Heckman; M Margaret Juliana; Clinton J Grubbs
Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C?
Oncology reports 2011;26(3):731-6.
2011: Jixia Li; Ronald A Lubet; Andria Carper; Yeon-Yong Cho; Marna E Ericson; Clinton J Grubbs; Alyssa Langfald; Ann M Bode
Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
Cancer prevention research (Philadelphia, Pa.) 2011;4(8):1190-7.
2011: Ronald A Lubet; Yan Lu; Ann M Bode; Ming You; Zoe M Verney; Vernon E Steele; Reid Townsend; M Margaret Juliana; Clinton J Grubbs
Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: dose dependency and modulation of biomarkers.
Oncology reports 2011;25(5):1389-97.
2010: Kyung Mi Lee; Ki Won Lee; Sung Keun Jung; Eun Jung Lee; Yong-Seok Heo; Ann M Bode; Ronald A Lubet; Hyong Joo Lee; Zigang Dong
Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity.
Biochemical pharmacology 2010;80(12):2042-9.
2010: Yian Wang; Michael James; Weidong Wen; Yan Lu; Eva Szabo; Ronald A Lubet; Ming You
Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice.
Molecular cancer therapeutics 2010;9(11):3074-82.
2010: Vernon E Steele; Ronald A Lubet
The use of animal models for cancer chemoprevention drug development.
Seminars in oncology 2010;37(4):327-38.
2010: Qi Zhang; Huijing Fu; Jing Pan; Jun He; Seto Ryota; Yukihiko Hara; Yian Wang; Ronald A Lubet; Ming You
Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.
Pharmaceutical research 2010;27(6):1066-71.
2010: Ronald A Lubet; Vernon E Steele; M Margaret Juliana; Clinton J Grubbs
Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy.
The Journal of urology 2010;183(4):1598-603.
2010: David L McCormick; K V N Rao; William D Johnson; Maarten C Bosland; Ronald A Lubet; Vernon E Steele
Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate.
Cancer prevention research (Philadelphia, Pa.) 2010;3(3):381-92.
2010: Yan Lu; Pengyuan Liu; Weidong Wen; Clinton J Grubbs; Reid R Townsend; James P Malone; Ronald A Lubet; Ming You
Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models.
American journal of translational research 2010;3(1):8-27.
2010: David L McCormick; Jonathan M Phillips; Thomas L Horn; William D Johnson; Vernon E Steele; Ronald A Lubet
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
Cancer prevention research (Philadelphia, Pa.) 2010;3(1):73-81.
2009: Yian Wang; Weidong Wen; Yijun Yi; Zhongqiu Zhang; Ronald A Lubet; Ming You
Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer.
Cancer prevention research (Philadelphia, Pa.) 2009;2(12):1059-64.
2009: Ronald A Lubet; Ruisheng Yao; Clinton J Grubbs; Ming You; Yian Wang
Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.
Chemico-biological interactions 2009;182(1):22-8.
2009: Vernon E Steele; Chinthalapally V Rao; Yuting Zhang; Jagan Patlolla; Daniel Boring; Levy Kopelovich; M Margaret Juliana; Clinton J Grubbs; Ronald A Lubet
Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers.
Cancer prevention research (Philadelphia, Pa.) 2009;2(11):951-6.
2009: Yian Wang; Zhongqiu Zhang; Joel R Garbow; Douglas Rowland; Ronald A Lubet; Daniel Sit; Francis Law; Ming You
Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs.
Cancer prevention research (Philadelphia, Pa.) 2009;2(7):634-40.
2009: Huijing Fu; Jun He; Fan Mei; Qi Zhang; Yukihiko Hara; Seto Ryota; Ronald A Lubet; Ruth Chen; Da-Ren Chen; Ming You
Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E).
Cancer prevention research (Philadelphia, Pa.) 2009;2(6):531-7.
2009: Ronald A Lubet; Daniel Boring; Vernon E Steele; J Michael Ruppert; M Margaret Juliana; Clinton J Grubbs
Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis.
Cancer prevention research (Philadelphia, Pa.) 2009;2(2):161-7.
2008: Ronald A Lubet; Susan M Fischer; Vernon E Steele; M Margaret Juliana; Renee A Desmond; Clinton J Grubbs
Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers.
International journal of cancer. Journal international du cancer 2008;123(10):2254-9.
2008: Margie L Clapper; Monique A Gary; Renata A Coudry; Samuel Litwin; Wen-Chi L Chang; Karthik Devarajan; Ronald A Lubet; Harry S Cooper
5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis.
Inflammatory bowel diseases 2008;14(10):1341-7.
2008: Ronald A Lubet; Eva Szabo; Konstantin Christov-Tzelkov; Ann M Bode; Marna E Ericson; Vernon E Steele; M Margaret Juliana; Clinton J Grubbs
Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes.
Molecular cancer therapeutics 2008;7(4):972-9.
2008: Joel R Garbow; Min Wang; Yian Wang; Ronald A Lubet; Ming You
Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1363-7.
2008: Fadel S Alyaqoub; Yue Liu; Lianhui Tao; Vernon E Steele; Ronald A Lubet; Michael A Pereira
Modulation by bexarotene of mRNA expression of genes in mouse lung tumors.
Molecular carcinogenesis 2008;47(3):165-71.
2008: Stephan Woditschka; Jill D Haag; Bob Mau; Ronald A Lubet; Michael N Gould
Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model.
Breast cancer research : BCR 2008;10(1):R18.
2007: Thomas L Horn; Karen E O Torres; Jennifer M Naylor; Michael J Cwik; Carol J Detrisac; Izet M Kapetanovic; Ronald A Lubet; James A Crowell; David L McCormick
Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):612-27.
2007: Konstantin Christov-Tzelkov; Clinton J Grubbs; Anne Shilkaitis; M Margaret Juliana; Ronald A Lubet
Short-term modulation of cell proliferation and apoptosis and preventive/therapeutic efficacy of various agents in a mammary cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5488-96.
2007: Ronald A Lubet; Chung S Yang; Mao-Jung Lee; Yukihiko Hara; Izet M Kapetanovic; James A Crowell; Vernon E Steele; M Margaret Juliana; Clinton J Grubbs
Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols.
Molecular cancer therapeutics 2007;6(7):2022-8.
2007: Long Li; Lianhui Tao; Ronald A Lubet; Vernon E Steele; Michael A Pereira
Modulation by budesonide of a CpG endonuclease in mouse lung tumors.
Carcinogenesis 2007;28(7):1499-503.
2007: Ruisheng Yao; Yijun Yi; Clinton J Grubbs; Ronald A Lubet; Ming You
Gene expression profiling of chemically induced rat bladder tumors.
Neoplasia (New York, N.Y.) 2007;9(3):207-21.
2007: Michael A Pereira; Lianhui Tao; Yue Liu; Long Li; Vernon E Steele; Ronald A Lubet
Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors.
International journal of cancer. Journal international du cancer 2007;120(5):1150-3.
2007: David L McCormick; William D Johnson; Nicole M Kozub; K V N Rao; Ronald A Lubet; Vernon E Steele; Maarten C Bosland
Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone.
Carcinogenesis 2007;28(2):398-403.
2007: Ying Yan; Qing Tan; Yian Wang; Daolong Wang; Mike Jin; Terry Gordon; Ronald A Lubet; Ming You
Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice.
Inhalation toxicology 2007;19 Suppl 1():183-7.
2007: David L McCormick; William D Johnson; Todd M Haryu; Maarten C Bosland; Ronald A Lubet; Vernon E Steele
Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat.
Nutrition and cancer 2007;57(2):194-200.
2007: David L McCormick; William D Johnson; Maarten C Bosland; Ronald A Lubet; Vernon E Steele
Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor.
Nutrition and cancer 2007;57(2):184-93.
2007: Fadel S Alyaqoub; Lianhui Tao; Paula M Kramer; Vernon E Steele; Ronald A Lubet; William Gunning; Michael A Pereira
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT).
Carcinogenesis 2007;28(1):124-9.
2006: Ying Yan; Yan Lu; Min Wang; Haris G Vikis; Ruisheng Yao; Yian Wang; Ronald A Lubet; Ming You
Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer.
Molecular cancer research : MCR 2006;4(12):971-81.
2006: Fadel S Alyaqoub; Lianhui Tao; Paula M Kramer; Vernon E Steele; Ronald A Lubet; William Gunning; Michael A Pereira
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).
Carcinogenesis 2006;27(12):2442-7.
2006: Stephan Woditschka; Jill D Haag; Jordy L Waller; Dinelli M Monson; Andrew A Hitt; Heidi L Brose; Rong Hu; Yun Zheng; Philip A Watson; Kwanghee Kim; Mary J Lindstrom; Bob Mau; Vernon E Steele; Ronald A Lubet; Michael N Gould
Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas.
Cancer research 2006;66(13):6884-91.
2006: Ruisheng Yao; Yian Wang; Yan Lu; William J Lemon; David W End; Clinton J Grubbs; Ronald A Lubet; Ming You
Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.
Carcinogenesis 2006;27(7):1420-31.
2006: Zhongqiu Zhang; Yian Wang; Ruisheng Yao; Jie Li; Ronald A Lubet; Ming You
p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer.
Molecular cancer research : MCR 2006;4(6):401-10.
2006: Clinton J Grubbs; Ronald A Lubet; Venkatram R Atigadda; Konstantin Christov-Tzelkov; Anil Deshpande; Vivek Tirmal; Gang Xia; Kirby I Bland; Isao Eto; Wayne J Brouillette; Donald D Muccio
Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers.
Carcinogenesis 2006;27(6):1232-9.
2006: sandra mulbah; Francesco D'Agostini; Gancho Ganchev; Alberto Izzotti; Barbara Di Marco; Ronald A Lubet; nicola zanesi; Carlo M Croce; Silvio De Flora
Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7823-8.
2006: Michael A Pereira; Paula M Kramer; Ronald Nines; Yue Liu; Fadel S Alyaqoub; William Gunning; Vernon E Steele; Ronald A Lubet
Prevention of mouse lung tumors by targretin.
International journal of cancer. Journal international du cancer 2006;118(9):2359-62.
2006: Ronald A Lubet; Konstantin Christov-Tzelkov; Ming You; Ruisheng Yao; Vernon E Steele; David W End; M Margaret Juliana; Clinton J Grubbs
Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations.
Molecular cancer therapeutics 2006;5(4):1073-8.
2006: Yian Wang; Ruisheng Yao; Anna Maciag; Clinton J Grubbs; Ronald A Lubet; Ming You
Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide.
Molecular cancer therapeutics 2006;5(4):1060-72.
2006: Y Wang; Z Zhang; R Yao; D Jia; Daolong Wang; Ronald A Lubet; M You
Prevention of lung cancer progression by bexarotene in mouse models.
Oncogene 2006;25(9):1320-9.
2006: Yian Wang; Z Zhang; Ronald A Lubet; Ming You
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
Oncogene 2006;25(8):1277-80.
2006: Yan Lu; Ruisheng Yao; Ying Yan; Yian Wang; Yukihiko Hara; Ronald A Lubet; Ming You
A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice.
Cancer research 2006;66(4):1956-63.
2006: Jamal M Arif; Carolyn Dresler; Margie L Clapper; C Gary Gairola; Cidambi Srinivasan; Ronald A Lubet; Ramesh C Gupta
Lung DNA adducts detected in human smokers are unrelated to typical polyaromatic carcinogens.
Chemical research in toxicology 2006;19(2):295-9.
2006: Yong Huang; Jian Yan; Ronald A Lubet; Thomas W Kensler; Thomas R Sutter
Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione.
Physiological genomics 2006;24(2):144-53.
2006: Ying Yan; Yian Wang; Qing Tan; Yukihiko Hara; Taik-Koo Yun; Ronald A Lubet; Ming You
Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Neoplasia (New York, N.Y.) 2006;8(1):52-8.
2005: Alberto Izzotti; Marcello Bagnasco; Cristina Cartiglia; Mariagrazia Longobardi; Anna Camoirano; Elena Tampa; Ronald A Lubet; Silvio De Flora
Modulation of multigene expression and proteome profiles by chemopreventive agents.
Mutation research 2005;591(1-2):212-23.
2005: Ying Yan; Yian Wang; Qing Tan; Ronald A Lubet; Ming You
Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Neoplasia (New York, N.Y.) 2005;7(12):1053-7.
2005: Richard Bachelier; Xiaoling Xu; Cuiling Li; Wenhui Qiao; Priscilla A Furth; Ronald A Lubet; Chu-Xia Deng
Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice.
Oncology reports 2005;14(5):1117-20.
2005: Zhongqiu Zhang; Ruisheng Yao; Jie Li; Yian Wang; Charles W Boone; Ronald A Lubet; Ming You
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Molecular cancer research : MCR 2005;3(10):563-74.
2005: Alberto Izzotti; Marcello Bagnasco; Cristina Cartiglia; Mariagrazia Longobardi; sandra mulbah; Andrea Merello; Ronald A Lubet; Silvio De Flora
Chemoprevention of genome, transcriptome, and proteome alterations induced by cigarette smoke in rat lung.
European journal of cancer (Oxford, England : 1990) 2005;41(13):1864-74.
2005: Stephen D Hursting; Nomeli P Nunez; Arti C Patel; Susan N Perkins; Ronald A Lubet; J Carl Barrett
The utility of genetically altered mouse models for nutrition and cancer chemoprevention research.
Mutation research 2005;576(1-2):80-92.
2005: Guobin He; Stephanie J. Muga; Philippe Thuillier; Ronald A Lubet; Susan M Fischer
The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin.
Molecular carcinogenesis 2005;43(4):198-206.
2005: Gulnur Guler; Dimitrios Iliopoulos; Shuang-Yin Han; Louise Y Y Fong; Ronald A Lubet; Clinton J Grubbs; Kay Huebner
Hypermethylation patterns in the Fhit regulatory region are tissue specific.
Molecular carcinogenesis 2005;43(3):175-81.
2005: Laundette Knight Jones; Minglin Li; Ewa D Halama; Yongxian Ma; Ronald A Lubet; Clinton J Grubbs; Chu-Xia Deng; Eliot M Rosen; Priscilla A Furth
Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer.
Oncogene 2005;24(22):3554-62.
2005: Keith Crist; Zhongqiu Zhang; Ming You; William Gunning; Phillip B Conran; Vernon E Steele; Ronald A Lubet
Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture.
Carcinogenesis 2005;26(5):951-7.
2005: Yian Wang; Zhongqiu Zhang; Ronald A Lubet; Ming You
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Oncogene 2005;24(18):3042-9.
2005: Ruisheng Yao; Yian Wang; Francesco D'Agostini; Alberto Izzotti; Ronald A Lubet; Ming You; Silvio De Flora
K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.
Experimental lung research 2005;31(2):271-81.
2005: Michael A Pereira; Lian H Tao; Wei Wang; William Gunning; Ronald A Lubet
Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker.
Experimental lung research 2005;31(2):145-63.
2005: Ronald A Lubet; Kay Huebner; Louise Y Y Fong; Dario C Altieri; Vernon E Steele; Levy Kopelovich; Claudine Kavanaugh; M Margaret Juliana; Seng-Jaw Soong; Clinton J Grubbs
4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin.
Carcinogenesis 2005;26(3):571-8.
2005: Ronald A Lubet; Konstantin Christov-Tzelkov; Nomeli P Nunez; Stephen D Hursting; Vernon E Steele; M Margaret Juliana; Isao Eto; Clinton J Grubbs
Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis.
Carcinogenesis 2005;26(2):441-8.
2005: Anne Shilkaitis; Albert Green; Vasu Punj; Vernon E Steele; Ronald A Lubet; Konstantin Christov-Tzelkov
Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism.
Breast cancer research : BCR 2005;7(6):R1132-40.
2005: Ronald A Lubet; Yian Wang; Zhongqiu Zhang; Ming You
Mouse models incorporating alterations in the major tumor suppressor genes P53 and P16: their use in screening for potential carcinogens, developing further relevant mouse models, and screening for potential chemopreventive and chemotherapetutic agents.
Experimental lung research 2005;31(1):117-33.
2005: Silvio De Flora; Alberto Izzotti; Francesco D'Agostini; Carlo Bennicelli; Ming You; Ronald A Lubet; sandra mulbah
Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice.
Experimental lung research 2005;31(1):19-35.
2005: Ernest T Hawk; Asad Umar; Ronald A Lubet; Levy Kopelovich; Jaye L Viner
Can animal models help us select specific compounds for cancer prevention trials?
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2005;166():71-87.
2005: Joyce E Rundhaug; Kathleen A Hawkins; Amy Pavone; Sally Gaddis; Hyunsuk Kil; Russell D Klein; Thomas R Berton; Elisabeth McCauley; David G Johnson; Ronald A Lubet; Susan M Fischer; C Marcelo Aldaz
SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects.
Molecular carcinogenesis 2005;42(1):40-52.
2004: Alberto Izzotti; Cristina Cartiglia; Mariagrazia Longobardi; Marcello Bagnasco; Andrea Merello; Ming You; Ronald A Lubet; Silvio De Flora
Gene expression in the lung of p53 mutant mice exposed to cigarette smoke.
Cancer research 2004;64(23):8566-72.
2004: Ruisheng Yao; Yian Wang; William J Lemon; Ronald A Lubet; Ming You
Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions.
Oncogene 2004;23(46):7746-52.
2004: Xiaoxin Chen; Su Wang; Nan Wu; Sandeep Sood; Peng Wang; Zhe Jin; David G Beer; Thomas J Giordano; Yong Lin; Wei-Chung J Shih; Ronald A Lubet; Chung S Yang
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(19):6703-9.
2004: Alberto Izzotti; Cristina Cartiglia; Mariagrazia Longobardi; sandra mulbah; Francesco D'Agostini; Ronald A Lubet; Silvio De Flora
Alterations of gene expression in skin and lung of mice exposed to light and cigarette smoke.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1559-61.
2004: Michael A Pereira; Lianhui Tao; Wei Wang; Yingzhe Li; Asad Umar; Vernon E Steele; Ronald A Lubet
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.
Carcinogenesis 2004;25(10):1917-23.
2004: Ruisheng Yao; William J Lemon; Yian Wang; Clinton J Grubbs; Ronald A Lubet; Ming You
Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine.
Neoplasia (New York, N.Y.) 2004;6(5):569-77.
2004: Russell F Jacoby; Carolyn E Cole; Ernest T Hawk; Ronald A Lubet
Ursodeoxycholate/Sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis.
Gastroenterology 2004;127(3):838-44.
2004: Konstantin Christov-Tzelkov; Richard C Moon; Daniel D Lantvit; Charles W Boone; Gary J Kelloff; Vernon E Steele; Ronald A Lubet; John M Pezzuto
Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.
European journal of cancer (Oxford, England : 1990) 2004;40(9):1404-11.
2004: Shuang-Yin Han; Dimitrios Iliopoulos; Teresa Druck; Gulnur Guler; Clinton J Grubbs; Michael Pereira; Zhongqiu Zhang; Ming You; Ronald A Lubet; Louise Y Y Fong; Kay Huebner
CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors.
Oncogene 2004;23(22):3990-8.
2004: Zhongqiu Zhang; Yian Wang; Ruisheng Yao; Jie Li; Ying Yan; Marie La Regina; William L Lemon; Clinton J Grubbs; Ronald A Lubet; Ming You
Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models.
Oncogene 2004;23(21):3841-50.
2004: Ronald A Lubet; Lianhui Tao; Wei Wang; Paula Kramer; Michael Perreira
Effects of budesonide on overall 5-methylcytosine levels and specific methylation and messenger RNA expression of the insulin-like growth factor II gene in mouse lung tumors.
Chest 2004;125(5 Suppl):157S.
2004: Ronald A Lubet; Zhongqiu Zhang; Yian Wang; Ming You
Chemoprevention of lung cancer in transgenic mice.
Chest 2004;125(5 Suppl):144S-7S.
2004: Yian Wang; Zhongqiu Zhang; Ying Yan; William J Lemon; Marie LaRegina; Carl Morrison; Ronald A Lubet; Ming You
A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility.
Cancer research 2004;64(5):1647-54.
2004: Allison E Bonner; William J Lemon; Theodora R Devereux; Ronald A Lubet; Ming You
Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas.
Oncogene 2004;23(5):1166-76.
2004: Lianhui Tao; Wei Wang; Paula M Kramer; Ronald A Lubet; Vernon E Steele; Michael A Pereira
Modulation of DNA hypomethylation as a surrogate endpoint biomarker for chemoprevention of colon cancer.
Molecular carcinogenesis 2004;39(2):79-84.
2004: Mark B Cope; Vernon E Steele; Ronald A Lubet; Isao Eto; M Margaret Juliana; Donald L Hill; Clinton J Grubbs
Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention.
Oncology reports 2004;11(2):465-9.
2003: Zhongqiu Zhang; Yian Wang; Laura E Lantry; Elizabeth Kastens; Gongjie Liu; Andrew D Hamilton; Said M Sebti; Ronald A Lubet; Ming You
Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf.
Oncogene 2003;22(40):6257-65.
2003: sandra mulbah; Alberto Izzotti; Francesco D'Agostini; Anna Camoirano; Marcello Bagnasco; Ronald A Lubet; Silvio De Flora
Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice.
Carcinogenesis 2003;24(9):1525-32.
2003: Yian Wang; Zhongqiu Zhang; Elizabeth Kastens; Ronald A Lubet; Ming You
Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice.
Cancer research 2003;63(15):4389-95.
2003: Susan M Fischer; Claudio J Conti; Jaye Viner; C Marcelo Aldaz; Ronald A Lubet
Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.
Carcinogenesis 2003;24(5):945-52.
2003: William Gunning; Paula M Kramer; Ronald A Lubet; Vernon E Steele; David W End; Walter Wouters; Michael A Pereira
Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1927-30.
2003: Minglin Li; Shuxun Ren; Maddalena T Tilli; Jodi A Flaws; Ronald A Lubet; Clinton J Grubbs; Priscilla A Furth
Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity.
Oncogene 2003;22(17):2568-72.
2003: Silvio De Flora; sandra mulbah; Francesco D'Agostini; Alberto Izzotti; Anna Camoirano; Carlo Bennicelli; Zhongqiu Zhang; Yian Wang; Ronald A Lubet; Ming You
Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke.
Cancer research 2003;63(4):793-800.
2003: Silvio De Flora; Francesco D'Agostini; sandra mulbah; Anna Camoirano; Carlo Bennicelli; Marcello Bagnasco; Cristina Cartiglia; Elena Tampa; Mariagrazia Longobardi; Ronald A Lubet; Alberto Izzotti
Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis.
Mutation research 2003;523-524():237-52.
2003: Vernon E Steele; Ernest T Hawk; Jaye L Viner; Ronald A Lubet
Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer.
Mutation research 2003;523-524():137-44.
2003: Konstantin Christov-Tzelkov; Amy Ikui; Anne Shilkaitis; Albert Green; Ruisheng Yao; Ming You; Clinton J Grubbs; Vernon E Steele; Ronald A Lubet; I Bernard Weinstein
Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors.
Breast cancer research and treatment 2003;77(3):253-64.
2003: Ruisheng Yao; Yian Wang; Ronald A Lubet; Ming You
Differential gene expression in chemically induced mouse lung adenomas.
Neoplasia (New York, N.Y.) 2003;5(1):41-52.
2003: Konstantin Christov-Tzelkov; Anne Shilkaitis; E S Kim; Vernon E Steele; Ronald A Lubet
Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours.
European journal of cancer (Oxford, England : 1990) 2003;39(2):230-9.
2002: Thomas R Sutter; Xiao-Rui He; Peter Dimitrov; Lijing Xu; Giri Narasimhan; E Olusegun George; Carrie Hayes Sutter; Clinton J Grubbs; Richard Savory; Markus Stephan-Gueldner; Dirk Kreder; Michael J Taylor; Ronald A Lubet; Tricia A Patterson; Thomas W Kensler
Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents.
Molecular cancer therapeutics 2002;1(14):1283-92.
2002: Claudine Kavanaugh; Kartiki V Desai; Alfonso Calvo; P H Brown; Christine Couldrey; Ronald A Lubet; Jeffrey E Green
Pre-clinical applications of transgenic mouse mammary cancer models.
Transgenic research 2002;11(6):617-33.
2002: Xiaoxin Chen; Ning Li; Su Wang; Jungil Hong; Mingzhu Fang; Joseph Yousselfson; Peiying Yang; Robert A Newman; Ronald A Lubet; Chung S Yang
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.
Carcinogenesis 2002;23(12):2095-102.
2002: Lianhui Tao; Yingzhe Li; Wei Wang; Paula M Kramer; William Gunning; Ronald A Lubet; Vernon E Steele; Michael A Pereira
Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors.
Molecular carcinogenesis 2002;35(2):93-102.
2002: Konstantin Christov-Tzelkov; Richard C Moon; Daniel D Lantvit; Charles W Boone; Vernon E Steele; Ronald A Lubet; Gary J Kelloff; John M Pezzuto
9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats.
Cancer research 2002;62(18):5178-82.
2002: Lianhui Tao; Paula M Kramer; Wei Wang; Siming Yang; Ronald A Lubet; Vernon E Steele; Michael A Pereira
Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents.
Carcinogenesis 2002;23(9):1447-54.
2002: Ruisheng Yao; Yian Wang; Ronald A Lubet; Ming You
Differentially expressed genes associated with mouse lung tumor progression.
Oncogene 2002;21(37):5814-21.
2002: Michael A Pereira; Yingzhe Li; William Gunning; Paula M Kramer; Fadel Al-Yaqoub; Ronald A Lubet; Vernon E Steele; Eva Szabo; Lianhui Tao
Prevention of mouse lung tumors by budesonide and its modulation of biomarkers.
Carcinogenesis 2002;23(7):1185-92.
2002: Zhongqiu Zhang; Jie Li; Laura E Lantry; Yian Wang; Roger W Wiseman; Ronald A Lubet; Ming You
p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.
Cancer research 2002;62(11):3024-9.
2002: Amy L McDoniels-Silvers; Caramella F Nimri; Gary D Stoner; Ronald A Lubet; Ming You
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1127-38.
2002: Amy L McDoniels-Silvers; Gary D Stoner; Ronald A Lubet; Ming You
Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues.
Neoplasia (New York, N.Y.) 2002;4(2):141-50.
2001: Yian Wang; L Hu; Ruisheng Yao; M Wang; Keith Crist; Clinton J Grubbs; Gary L Johanning; Ronald A Lubet; Ming You
Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor.
Oncogene 2001;20(53):7710-21.
2001: Jeffrey E Green; MA Shibata; E Shibata; R C Moon; Miriam R Anver; Gary J Kelloff; Ronald A Lubet
2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice.
Cancer research 2001;61(20):7449-55.
2001: Gary L Johanning; Mark B Cope; TW Wilborn; Clinton J Grubbs; Ronald A Lubet
Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.
Anticancer research 2001;21(3B):1691-5.
2001: Gary J Kelloff; Ronald Lieberman; Vernon E Steele; Charles W Boone; Ronald A Lubet; Levy Kopelovich; WA Malone; James A Crowell; H R Higley; Caroline C Sigman
Agents, biomarkers, and cohorts for chemopreventive agent development in prostate cancer.
Urology 2001;57(4 Suppl 1):46-51.
2001: L Lin; Yian Wang; G Bergman; Gary J Kelloff; Ronald A Lubet; Ming You
Detection of differentially expressed genes in mouse lung adenocarcinomas.
Experimental lung research 2001;27(3):217-29.
2001: Alberto Izzotti; sandra mulbah; F Dagostini; Carlo Bennicelli; S R Myers; C J Grubbs; Ronald A Lubet; GJ Kelloff; Silvio De Flora
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
Cancer research 2001;61(6):2472-9.
2001: Francesco D'Agostini; sandra mulbah; Alberto Izzotti; Ronald A Lubet; GJ Kelloff; Silvio De Flora
Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.
Carcinogenesis 2001;22(3):375-80.
2001: Cristina Rodríguez-Burford; Ronald A Lubet; Vernon E Steele; Isao Eto; M Bandy; M Margaret Juliana; Heidi L Weiss; William E Grizzle; Gary J Kelloff; Clinton J Grubbs
Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention.
Oncology reports 2001;8(2):373-9.
2001: Francesco D'Agostini; sandra mulbah; Carlo Bennicelli; Ronald A Lubet; GJ Kelloff; Silvio De Flora
Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice.
International journal of oncology 2001;18(3):607-15.
2001: Jo Anne Zujewski; A Vaughn-Cooke; Kathleen C Flanders; Michael Eckhaus; Ronald A Lubet; Lalage M Wakefield
Transforming growth factors-beta are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system.
Breast cancer research : BCR 2001;3(1):66-75.
2000: Laura E Lantry; Zhongqiu Zhang; Keith Crist; Yian Wang; M Hara; A Zeeck; Ronald A Lubet; Ming You
Chemopreventive efficacy of promising farnesyltransferase inhibitors.
Experimental lung research 2000;26(8):773-90.
2000: William Gunning; Paula M Kramer; Ronald A Lubet; Vernon E Steele; Michael A Pereira
Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice.
Experimental lung research 2000;26(8):757-72.
2000: Ronald A Lubet; Z Zhang; R W Wiseman; Ming You
Use of p53 transgenic mice in the development of cancer models for multiple purposes.
Experimental lung research 2000;26(8):581-93.
2000: Clinton J Grubbs; Ronald A Lubet; Alane T Koki; Kathleen M Leahy; Jaime L Masferrer; Vernon E Steele; Gary J Kelloff; Donald L Hill; Karen Seibert
Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats.
Cancer research 2000;60(20):5599-602.
2000: Russell F Jacoby; K Seibert; Carolyn E Cole; Gary J Kelloff; Ronald A Lubet
The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.
Cancer research 2000;60(18):5040-4.
2000: Vernon E Steele; CA Holmes; Ernest T Hawk; Levy Kopelovich; Ronald A Lubet; James A Crowell; Caroline C Sigman; Gary J Kelloff
Potential use of lipoxygenase inhibitors for cancer chemoprevention.
Expert opinion on investigational drugs 2000;9(9):2121-38.
2000: Anne Shilkaitis; J Graves; Rajeshwari R Mehta; L Hu; M You; Ronald A Lubet; Vernon E Steele; Gary J Kelloff; Konstantin Christov-Tzelkov
Bcl-2 and Bax are differentially expressed in hyperplastic, premalignant, and malignant lesions of mammary carcinogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(8):437-45.
2000: Jamal M Arif; C Gary Gairola; G J Kelloff; Ronald A Lubet; Ramesh C Gupta
Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol.
Mutation research 2000;452(1):11-8.
2000: Francesco D'Agostini; sandra mulbah; Carlo Pesce; Paolo Fiallo; Ronald A Lubet; G J Kelloff; Silvio De Flora
Induction of alopecia in mice exposed to cigarette smoke.
Toxicology letters 2000;114(1-3):117-23.
2000: Russell F Jacoby; Carolyn E Cole; Kendra Tutsch; Michael A Newton; Gary J Kelloff; Ernest T Hawk; Ronald A Lubet
Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos.
Cancer research 2000;60(7):1864-70.
2000: Richard B Halberg; D S Katzung; P D Hoff; AR Moser; Carolyn E Cole; Ronald A Lubet; L A Donehower; Russell F Jacoby; William F Dove
Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3461-6.
2000: Konstantin Christov-Tzelkov; Anne Shilkaitis; Albert Green; Rajendra Mehta; Clinton J Grubbs; Gary J Kelloff; Ronald A Lubet
Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole.
Breast cancer research and treatment 2000;60(2):117-28.
2000: Zhongqiu Zhang; Q Liu; Laura E Lantry; Yian Wang; Gary J Kelloff; M W Anderson; R W Wiseman; Ronald A Lubet; Ming You
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
Cancer research 2000;60(4):901-7.
2000: Gary J Kelloff; James A Crowell; Vernon E Steele; Ronald A Lubet; WA Malone; Charles W Boone; Levy Kopelovich; Ernest T Hawk; Ronald Lieberman; JA Lawrence; I Ali; Jaye L Viner; Caroline C Sigman
Progress in cancer chemoprevention: development of diet-derived chemopreventive agents.
The Journal of nutrition 2000;130(2S Suppl):467S-471S.
2000: Anne Shilkaitis; Albert Green; Vernon E Steele; Ronald A Lubet; Gary J Kelloff; Konstantin Christov-Tzelkov
Neoplastic transformation of mammary epithelial cells in rats is associated with decreased apoptotic cell death.
Carcinogenesis 2000;21(2):227-33.
2000: Bandaru S Reddy; Y Hirose; Ronald A Lubet; VE Steele; Gary J Kelloff; S Paulson; K Seibert; Chinthalapally V Rao
Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.
Cancer research 2000;60(2):293-7.
2000: Laura E Lantry; Zhongqiu Zhang; R Yao; Keith Crist; Yian Wang; J Ohkanda; A D Hamilton; Said M Sebti; Ronald A Lubet; Ming You
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Carcinogenesis 2000;21(1):113-6.
1999: H Li; Paula M Kramer; Ronald A Lubet; Vernon E Steele; Gary J Kelloff; Michael A Pereira
Termination of piroxicam treatment and the occurrence of azoxymethane-induced colon cancer in rats.
Cancer letters 1999;147(1-2):187-93.
1999: Ernest T Hawk; Ronald A Lubet; Paul Limburg
Chemoprevention in hereditary colorectal cancer syndromes.
Cancer 1999;86(11 Suppl):2551-63.
1999: Alberto Izzotti; Anna Camoirano; Cristina Cartiglia; C J Grubbs; Ronald A Lubet; GJ Kelloff; Silvio De Flora
Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents.
Cancer research 1999;59(17):4285-90.
1999: Susan M Fischer; HH Lo; Gary B Gordon; K Seibert; Gary J Kelloff; Ronald A Lubet; Claudio J Conti
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis.
Molecular carcinogenesis 1999;25(4):231-40.
1999: Bandaru S Reddy; Toshihiko Kawamori; Ronald A Lubet; VE Steele; Gary J Kelloff; Chinthalapally V Rao
Chemopreventive effect of S-methylmethane thiosulfonate and sulindac administered together during the promotion/progression stages of colon carcinogenesis.
Carcinogenesis 1999;20(8):1645-8.
1999: Alberto Izzotti; Marcello Bagnasco; Francesco D'Agostini; Cristina Cartiglia; Ronald A Lubet; GJ Kelloff; Silvio De Flora
Formation and persistence of nucleotide alterations in rats exposed whole-body to environmental cigarette smoke.
Carcinogenesis 1999;20(8):1499-505.
1999: Bandaru S Reddy; Toshihiko Kawamori; Ronald A Lubet; VE Steele; Gary J Kelloff; Chinthalapally V Rao
Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.
Cancer research 1999;59(14):3387-91.
1999: Vernon E Steele; CA Holmes; Ernest T Hawk; Levy Kopelovich; Ronald A Lubet; James A Crowell; Caroline C Sigman; Gary J Kelloff
Lipoxygenase inhibitors as potential cancer chemopreventives.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(5):467-83.
1999: Andrzej K Bednarek; Anne Shilkaitis; A Green; Ronald A Lubet; Gary J Kelloff; Konstantin Christov-Tzelkov; C Marcelo Aldaz
Suppression of cell proliferation and telomerase activity in 4-(hydroxyphenyl)retinamide-treated mammary tumors.
Carcinogenesis 1999;20(5):879-83.
1999: H Li; Herman A J Schut; Phillip B Conran; Paula M Kramer; Ronald A Lubet; Vernon E Steele; E E Hawk; Gary J Kelloff; Michael A Pereira
Prevention by aspirin and its combination with alpha-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon.
Carcinogenesis 1999;20(3):425-30.
1999: Laura E Lantry; Zhongqiu Zhang; Keith Crist; Yian Wang; Gary J Kelloff; Ronald A Lubet; Ming You
5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model.
Carcinogenesis 1999;20(2):343-6.
1999: Y Zheng; Paula M Kramer; Ronald A Lubet; Vernon E Steele; Gary J Kelloff; Michael A Pereira
Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci.
Carcinogenesis 1999;20(2):255-60.
1999: Toshihiko Kawamori; Ronald A Lubet; VE Steele; Gary J Kelloff; R B Kaskey; Chinthalapally V Rao; Bandaru S Reddy
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.
Cancer research 1999;59(3):597-601.
1999: Gary J Kelloff; James A Crowell; Vernon E Steele; Ronald A Lubet; Charles W Boone; WA Malone; Ernest T Hawk; Ronald Lieberman; JA Lawrence; Levy Kopelovich; I Ali; Jaye L Viner; Caroline C Sigman
Progress in cancer chemoprevention.
Annals of the New York Academy of Sciences 1999;889():1-13.
1999: Gary J Kelloff; Ronald Lieberman; Vernon E Steele; Charles W Boone; Ronald A Lubet; L Kopelovitch; WA Malone; James A Crowell; Caroline C Sigman
Chemoprevention of prostate cancer: concepts and strategies.
European urology 1999;35(5-6):342-50.
1999: Cristina Rodríguez-Burford; Ronald A Lubet; Isao Eto; M Margaret Juliana; Gary J Kelloff; Clinton J Grubbs; Vernon E Steele
Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model.
Carcinogenesis 1999;20(1):71-6.
1998: Thomas R Berton; Claudio J Conti; D L Mitchell; C Marcelo Aldaz; Ronald A Lubet; Susan M Fischer
The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis.
Molecular carcinogenesis 1998;23(3):175-84.
1998: Vernon E Steele; Charles W Boone; Ronald A Lubet; James A Crowell; CA Holmes; Caroline C Sigman; Gary J Kelloff
Preclinical drug development paradigms for chemopreventives.
Hematology/oncology clinics of North America 1998;12(5):943-61, v-vi.
1998: Jamal M Arif; C Gary Gairola; Howard P Glauert; G J Kelloff; Ronald A Lubet; Ramesh C Gupta
Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz.
Carcinogenesis 1998;19(8):1515-7.
1998: Ronald A Lubet; Vernon E Steele; R DeCoster; C Bowden; Ming You; M Margaret Juliana; Isao Eto; Gary J Kelloff; Clinton J Grubbs
Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model.
Carcinogenesis 1998;19(8):1345-51.
1998: Carol L K Sabourin; Q S Wang; S L Ralston; J Evans; J Coate; Christopher R Herzog; S L Jones; Christopher M Weghorst; Gary J Kelloff; Ronald A Lubet; Ming You; Gary D Stoner
Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors.
Experimental lung research 1998;24(4):499-521.
1998: Ronald A Lubet; Gary B Gordon; Russell A Prough; X D Lei; Ming You; Yunfei Wang; Clinton J Grubbs; Vernon E Steele; Gary J Kelloff; C F Thomas; R D Moon
Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations.
Cancer research 1998;58(5):921-6.
1998: H Li; Paula M Kramer; Ronald A Lubet; Vernon E Steele; Gary J Kelloff; Michael A Pereira
Effect of calcium on azoxymethane-induced aberrant crypt foci and cell proliferation in the colon of rats.
Cancer letters 1998;124(1):39-46.
1998: Gary J Kelloff; Ronald A Lubet; Ronald Lieberman; K Eisenhauer; Vernon E Steele; James A Crowell; Ernest T Hawk; Charles W Boone; Caroline C Sigman
Aromatase inhibitors as potential cancer chemopreventives.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(1):65-78.
1997: Y Zheng; Paula M Kramer; G Olson; Ronald A Lubet; Vernon E Steele; Gary J Kelloff; Michael A Pereira
Prevention by retinoids of azoxymethane-induced tumors and aberrant crypt foci and their modulation of cell proliferation in the colon of rats.
Carcinogenesis 1997;18(11):2119-25.
1997: Chinthalapally V Rao; C X Wang; B Simi; Ronald A Lubet; Gary J Kelloff; VE Steele; Bandaru S Reddy
Enhancement of experimental colon cancer by genistein.
Cancer research 1997;57(17):3717-22.
1997: Ronald A Lubet; Vernon E Steele; Isao Eto; M Margaret Juliana; Gary J Kelloff; Clinton J Grubbs
Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.
International journal of cancer. Journal international du cancer 1997;72(1):95-101.
1997: S A Matzinger; B Chen; Yian Wang; Keith Crist; G D Stoner; Gary J Kelloff; Ronald A Lubet; Ming You
Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice.
Gene 1997;188(2):261-9.
1997: Gary J Kelloff; Ronald A Lubet; Judith R Fay; Vernon E Steele; Charles W Boone; James A Crowell; Caroline C Sigman
Farnesyl protein transferase inhibitors as potential cancer chemopreventives.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(4):267-82.
1997: Bandaru S Reddy; C X Wang; HS Samaha; Ronald A Lubet; VE Steele; Gary J Kelloff; Chinthalapally V Rao
Chemoprevention of colon carcinogenesis by dietary perillyl alcohol.
Cancer research 1997;57(3):420-5.
1997: Keith Crist; Yian Wang; Ronald A Lubet; Vernon E Steele; Gary J Kelloff; Ming You
Effect of early vs. late administration of 4-hydroxyphenylretinamide (4-HPR) on N-methyl-N-nitrosourea (MNU)-induced mammary tumorigenesis.
Journal of cellular biochemistry. Supplement 1997;27():92-9.
1997: Laura E Lantry; Zhongqiu Zhang; F Gao; Keith Crist; Yian Wang; Gary J Kelloff; Ronald A Lubet; Ming You
Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
Journal of cellular biochemistry. Supplement 1997;27():20-5.
1997: L Hu; L Lin; Keith Crist; Gary J Kelloff; Vernon E Steele; Ronald A Lubet; Ming You; Yian Wang
Detection of differentially expressed genes in methylnitrosourea-induced rat mammary adenocarcinomas.
Journal of cellular biochemistry. Supplement 1997;28-29():117-24.
1997: CR Herzog; Ronald A Lubet; Ming You
Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.
Journal of cellular biochemistry. Supplement 1997;28-29():49-63.
1997: Gary J Kelloff; Charles W Boone; James A Crowell; S G Nayfield; Ernest T Hawk; Vernon E Steele; Ronald A Lubet; Caroline C Sigman
Perspectives and progress in development of breast cancer chemopreventive drugs.
Progress in clinical and biological research 1997;396():159-83.
1996: Gary J Kelloff; Ernest T Hawk; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Caroline C Sigman
Perspectives on chemoprevention agent selection and short-term clinical prevention trials.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1996;5 Suppl 2():79-85.
1996: E T Hellriegel; George Matwyshyn; P Fei; K H Dragnev; Raymond W Nims; Ronald A Lubet; Ah-Ng Tony Kong
Regulation of gene expression of various phase I and phase II drug-metabolizing enzymes by tamoxifen in rat liver.
Biochemical pharmacology 1996;52(10):1561-8.
1996: Gary J Kelloff; Ernest T Hawk; James A Crowell; Charles W Boone; S G Nayfield; M Perloff; V E Steele; Ronald A Lubet
Strategies for identification and clinical evaluation of promising chemopreventive agents.
Oncology (Williston Park, N.Y.) 1996;10(10):1471-84; discussion 1484-8.
1996: Gary J Kelloff; J R Fay; V E Steele; Ronald A Lubet; Charles W Boone; James A Crowell; Caroline C Sigman
Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1996;5(8):657-66.
1996: M A Pereira; Clinton J Grubbs; L H Barnes; H Li; G R Olson; Isao Eto; M Margaret Juliana; L M Whitaker; Gary J Kelloff; V E Steele; Ronald A Lubet
Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats.
Carcinogenesis 1996;17(6):1305-11.
1996: Gary J Kelloff; James A Crowell; Ernest T Hawk; V E Steele; Ronald A Lubet; Charles W Boone; J M Covey; L A Doody; Gilbert S Omenn; Peter Greenwald; Waun Ki Hong; D R Parkinson; D Bagheri; G T Baxter; M Blunden; M K Doeltz; K M Eisenhauer; K Johnson; G G Knapp; D G Longfellow; W F Malone; S G Nayfield; H E Seifried; L M Swall; Caroline C Sigman
Strategy and planning for chemopreventive drug development: clinical development plans II.
Journal of cellular biochemistry. Supplement 1996;26():54-71.
1996: Gary J Kelloff; Charles W Boone; James A Crowell; V E Steele; Ronald A Lubet; L A Doody; W F Malone; Ernest T Hawk; Caroline C Sigman
New agents for cancer chemoprevention.
Journal of cellular biochemistry. Supplement 1996;26():1-28.
1996: Gary J Kelloff; Charles W Boone; James A Crowell; S G Nayfield; Ernest T Hawk; W F Malone; V E Steele; Ronald A Lubet; Caroline C Sigman
Risk biomarkers and current strategies for cancer chemoprevention.
Journal of cellular biochemistry. Supplement 1996;25():1-14.
1996: Gary J Kelloff; Charles W Boone; V E Steele; James A Crowell; Ronald A Lubet; Peter Greenwald; Ernest T Hawk; J R Fay; Caroline C Sigman
Mechanistic considerations in the evaluation of chemopreventive data.
IARC scientific publications 1996;(139):203-19.
1995: Ronald A Lubet; D M McCormick; G M Gordon; Clinton J Grubbs; X D Lei; Russell A Prough; V E Steele; Gary J Kelloff; C F Thomas; R D Moon
Effects of dehydroepiandrosterone on MNU-induced breast cancer in Sprague-Dawley rats.
Annals of the New York Academy of Sciences 1995;774():340-1.
1995: K H Dragnev; Raymond W Nims; Ronald A Lubet
The chemopreventive agent diallyl sulfide. A structurally atypical phenobarbital-type inducer.
Biochemical pharmacology 1995;50(12):2099-104.
1995: S A Matzinger; Keith Crist; Gary D Stoner; M W Anderson; Michael A Pereira; V E Steele; Gary J Kelloff; Ronald A Lubet; Ming You
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
Carcinogenesis 1995;16(10):2487-92.
1995: L E Beebe; L W Fornwald; William L Alworth; K H Dragnev; Ronald A Lubet
Effect of dietary Aroclor 1254 exposure on lung and kidney cytochromes P450 in female rats: evidence for P4501A2 expression in kidney.
Chemico-biological interactions 1995;97(3):215-27.
1995: K H Dragnev; Raymond W Nims; Stephen D Fox; R Lindahl; Ronald A Lubet
Relative potencies of induction of hepatic drug-metabolizing enzyme genes by individual PCB congeners.
Toxicology and applied pharmacology 1995;132(2):334-42.
1995: Gary J Kelloff; Charles W Boone; James A Crowell; S G Nayfield; Ernest T Hawk; V E Steele; Ronald A Lubet; Caroline C Sigman
Strategies for phase II cancer chemoprevention trials: cervix, endometrium, and ovary.
Journal of cellular biochemistry. Supplement 1995;23():1-9.
1994: Raymond W Nims; Jaspreet S Sidhu; P E Thomas; D W Mellini; V C Nelson; C J Omiecinski; Ronald A Lubet
Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5-ethyl-5-phenylhydantoin in the male rat liver or in cultured rat hepatocytes.
Journal of biochemical toxicology 1994;9(6):279-88.
1994: Raymond W Nims; Stephen D Fox; Haleem J Issaq; Ronald A Lubet
Accumulation and persistence of individual polychlorinated biphenyl congeners in liver, blood, and adipose tissue of rats following dietary exposure to Aroclor 1254.
Archives of environmental contamination and toxicology 1994;27(4):513-20.
1994: Raymond W Nims; Ronald A Lubet; B A Diwan; D W Mellini; W E Utermahlen; P E Thomas
Hepatic cytochrome P450 2B induction by ethyl/phenyl-substituted congeners of phenobarbital in the B6C3F1 mouse.
Journal of biochemical toxicology 1994;9(5):269-78.
1994: Raymond W Nims; R M McClain; P S Manchand; P S Belica; P E Thomas; D W Mellini; W E Utermahlen; Ronald A Lubet
Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat.
The Journal of pharmacology and experimental therapeutics 1994;270(1):348-55.
1994: Richard C Moon; V E Steele; Gary J Kelloff; C F Thomas; C J Detrisac; Rajendra Mehta; Ronald A Lubet
Chemoprevention of MNU-induced mammary tumorigenesis by hormone response modifiers: toremifene, RU 16117, tamoxifen, aminoglutethimide and progesterone.
Anticancer research 1994;14(3A):889-93.
1994: Gary J Kelloff; Charles W Boone; V E Steele; James A Crowell; Ronald A Lubet; Caroline C Sigman
Progress in cancer chemoprevention: perspectives on agent selection and short-term clinical intervention trials.
Cancer research 1994;54(7 Suppl):2015s-2024s.
1994: J R Henneman; Stephen D Fox; Ronald A Lubet; J M Ward; Raymond W Nims
Induction of cytochrome P-450 in Sigmodon hispidus (cotton rats) exposed to dietary Aroclor 1254.
Journal of toxicology and environmental health 1994;41(3):369-86.
1994: K H Dragnev; L E Beebe; C R Jones; Stephen D Fox; P E Thomas; Raymond W Nims; Ronald A Lubet
Subchronic dietary exposure to Aroclor 1254 in rats: accumulation of PCBs in liver, blood, and adipose tissue and its relationship to induction of various hepatic drug-metabolizing enzymes.
Toxicology and applied pharmacology 1994;125(1):111-22.
1994: Gary J Kelloff; Charles W Boone; James A Crowell; V E Steele; Ronald A Lubet; Caroline C Sigman
Chemopreventive drug development: perspectives and progress.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1994;3(1):85-98.
1994: Gary J Kelloff; Charles W Boone; James A Crowell; V E Steele; Ronald A Lubet; L A Doody
Surrogate endpoint biomarkers for phase II cancer chemoprevention trials.
Journal of cellular biochemistry. Supplement 1994;19():1-9.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: calcium.
Journal of cellular biochemistry. Supplement 1994;20():86-109.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: aspirin.
Journal of cellular biochemistry. Supplement 1994;20():74-85.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: N-Acetyl-l-cysteine.
Journal of cellular biochemistry. Supplement 1994;20():63-73.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Strategy and planning for chemopreventive drug development: clinical development plans. Chemoprevention Branch and Agent Development Committee. National Cancer Institute.
Journal of cellular biochemistry. Supplement 1994;20():55-62.
1994: V E Steele; R C Moon; Ronald A Lubet; C J Grubbs; B S Reddy; Michael J Wargovich; David McCormick; M A Pereira; James A Crowell; D Bagheri
Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: methods and results from the NCI Chemoprevention Drug Development Program.
Journal of cellular biochemistry. Supplement 1994;20():32-54.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: vitamin E.
Journal of cellular biochemistry. Supplement 1994;20():282-99.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: vitamin D3 and analogs.
Journal of cellular biochemistry. Supplement 1994;20():268-81.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: tamoxifen.
Journal of cellular biochemistry. Supplement 1994;20():252-67.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: sulindac.
Journal of cellular biochemistry. Supplement 1994;20():240-51.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: Proscar.
Journal of cellular biochemistry. Supplement 1994;20():231-9.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: piroxicam.
Journal of cellular biochemistry. Supplement 1994;20():219-30.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: oltipraz.
Journal of cellular biochemistry. Supplement 1994;20():205-18.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: ibuprofen.
Journal of cellular biochemistry. Supplement 1994;20():197-204.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: N-(4-hydroxyphenyl)retinamide.
Journal of cellular biochemistry. Supplement 1994;20():176-96.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: 18beta-glycyrrhetinic acid.
Journal of cellular biochemistry. Supplement 1994;20():166-75.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: 2-difluoromethylornithine (DFMO).
Journal of cellular biochemistry. Supplement 1994;20():147-65.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: DHEA analog 8354.
Journal of cellular biochemistry. Supplement 1994;20():141-6.
1994: Gary J Kelloff; James A Crowell; Charles W Boone; V E Steele; Ronald A Lubet; Peter Greenwald; D S Alberts; J M Covey; L A Doody; G G Knapp
Clinical development plan: beta-carotene and other carotenoids.
Journal of cellular biochemistry. Supplement 1994;20():110-140.
1994: Gary J Kelloff; Charles W Boone; V E Steele; J R Fay; Ronald A Lubet; James A Crowell; Caroline C Sigman
Mechanistic considerations in chemopreventive drug development.
Journal of cellular biochemistry. Supplement 1994;20():1-24.
1993: Raymond W Nims; P R Sinclair; J F Sinclair; K H Dragnev; C R Jones; D W Mellini; P E Thomas; Ronald A Lubet
Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzne (TCPOBOP) in rat and cultured rat hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(12):1411-26.
1993: P V Nerurkar; S S Park; P E Thomas; Raymond W Nims; Ronald A Lubet
Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse.
Biochemical pharmacology 1993;46(5):933-43.
1993: Raymond W Nims; P R Sinclair; J F Sinclair; P E Thomas; C R Jones; D W Mellini; J L Syi; Ronald A Lubet
Pharmacodynamics of cytochrome P450 2B induction by phenobarbital, 5-ethyl-5-phenylhydantoin, and 5-ethyl-5-phenyloxazolidinedione in the male rat liver or in cultured rat hepatocytes.
Chemical research in toxicology 1993;6(2):188-96.
1993: Raymond W Nims; J L Syi; David A Wink; V C Nelson; P E Thomas; C R Jones; Bhalchandra A Diwan; Larry K Keefer; Jerry M Rice; Ronald A Lubet
Hepatic cytochrome P450 2B-type induction by ethyl/phenyl-substituted congeners of phenobarbital in the rat.
Chemical research in toxicology 1993;6(2):180-7.
1993: Raymond W Nims; Ronald A Lubet; C R Jones; D W Mellini; P E Thomas
Comparative pharmacodynamics of CYP2B induction by phenobarbital in the male and female F344/NCr rat.
Biochemical pharmacology 1993;45(2):521-6.
1993: Gary J Kelloff; Charles W Boone; V E Steele; James A Crowell; Ronald A Lubet; L A Doody; Peter Greenwald
Development of breast cancer chemopreventive drugs.
Journal of cellular biochemistry. Supplement 1993;17G():2-13.
1992: Raymond W Nims; L E Beebe; K H Dragnev; P E Thomas; Stephen D Fox; Haleem J Issaq; C R Jones; Ronald A Lubet
Induction of hepatic CYP1A in male F344/NCr rats by dietary exposure to Aroclor 1254: examination of immunochemical, RNA, catalytic, and pharmacokinetic endpoints.
Environmental research 1992;59(2):447-66.
1992: C R Jones; Ronald A Lubet
Induction of a pleiotropic response by phenobarbital and related compounds. Response in various inbred strains of rats, response in various species and the induction of aldehyde dehydrogenase in Copenhagen rats.
Biochemical pharmacology 1992;44(8):1651-60.
1992: Bhalchandra A Diwan; Ronald A Lubet; J M Ward; J A Hrabie; Jerry M Rice
Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine.
Carcinogenesis 1992;13(10):1893-901.
1992: C R Jones; F P Guengerich; Jerry M Rice; Ronald A Lubet
Induction of various cytochromes CYP2B, CYP2C and CYP3A by phenobarbitone in non-human primates.
Pharmacogenetics 1992;2(4):160-72.
1992: Ronald A Lubet; Raymond W Nims; L E Beebe; Stephen D Fox; Haleem J Issaq; K McBee
Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor 1254 in feral rodents.
Archives of environmental contamination and toxicology 1992;22(3):339-44.
1992: Ronald A Lubet; Raymond W Nims; K H Dragnev; C R Jones; Bhalchandra A Diwan; D E Devor; J M Ward; M S Miller; Jerry M Rice
A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats.
Biochemical pharmacology 1992;43(5):1079-87.
1992: Ronald A Lubet; K H Dragnev; D P Chauhan; Raymond W Nims; Bhalchandra A Diwan; J M Ward; C R Jones; Jerry M Rice; M S Miller
A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat. Effects of chemicals of varied structure.
Biochemical pharmacology 1992;43(5):1067-78.
1992: Jerry M Rice; Bhalchandra A Diwan; J M Ward; Raymond W Nims; Ronald A Lubet
Phenobarbital and related compounds: approaches to interspecies extrapolation.
Progress in clinical and biological research 1992;374():231-49.
1992: Bhalchandra A Diwan; Raymond W Nims; J R Henneman; J M Ward; Ronald A Lubet; Jerry M Rice
Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.
Archives of toxicology 1992;66(6):413-22.
1991: Ronald A Lubet; C R Jones; D L Stockus; Stephen D Fox; Raymond W Nims
Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254.
Toxicology and applied pharmacology 1991;108(2):355-65.
1991: J M Ward; Christopher M Weghorst; Bhalchandra A Diwan; N Konishi; Ronald A Lubet; J R Henneman; D E Devor
Evaluation of cell proliferation in the kidneys of rodents with bromodeoxyuridine immunohistochemistry of tritiated thymidine autoradiography after exposure to renal toxins, tumor promoters, and carcinogens.
Progress in clinical and biological research 1991;369():369-88.
1990: T L McLemore; S Adelberg; Mark C Liu; N A McMahon; S J Yu; Walter Hubbard; M Czerwinski; T G Wood; R Storeng; Ronald A Lubet
Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.
Journal of the National Cancer Institute 1990;82(16):1333-9.
1990: Ronald A Lubet; F P Guengerich; Raymond W Nims
The induction of alkoxyresorufin metabolism: a potential indicator of environmental contamination.
Archives of environmental contamination and toxicology 1990;19(2):157-63.
1990: Ronald A Lubet; J L Syi; J O Nelson; Raymond W Nims
Induction of hepatic cytochrome P-450 mediated alkoxyresorufin O-dealkylase activities in different species by prototype P-450 inducers.
Chemico-biological interactions 1990;75(3):325-39.
1990: J T McCarvill; Ronald A Lubet; L M Schechtman; R E Kouri; D L Putman
Morphological transformation of BALB/3T3 cells by various procarcinogens in the presence of a rat liver S-9 activation system.
Environmental and molecular mutagenesis 1990;16(4):304-10.
1990: J M Ward; Bhalchandra A Diwan; Ronald A Lubet; J R Henneman; D E Devor
Liver tumor promoters and other mouse liver carcinogens.
Progress in clinical and biological research 1990;331():85-108.
1990: Ronald A Lubet; R E Kouri; rodger curren; D L Putman; L M Schechtman
Induction of mutagenesis and transformation in BALB/c-3T3 clone A31-1 cells by diverse chemical carcinogens.
Environmental and molecular mutagenesis 1990;16(1):13-20.
1989: Bhalchandra A Diwan; Ronald A Lubet; Raymond W Nims; J E Klaunig; Christopher M Weghorst; J R Henneman; J M Ward; Jerry M Rice
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Carcinogenesis 1989;10(9):1719-24.
1989: Ronald A Lubet; C E McKinney; J W Cameron; F P Guengerich; R W Nims
Preferential activation of 6-aminochrysene and 2-aminoanthracene to mutagenic moieties by different forms of cytochrome P450 in hepatic 9000 X g supernatants from the rat.
Mutation research 1989;212(2):275-84.
1987: L M Schechtman; E Kiss; J McCarvill; R Nims; R E Kouri; Ronald A Lubet
A method for the amplification of chemically induced transformation in C3H/10T1/2 clone 8 cells: its use as a potential screening assay.
Journal of the National Cancer Institute 1987;79(3):487-98.
1987: Raymond W Nims; D E Devor; J R Henneman; Ronald A Lubet
Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates.
Carcinogenesis 1987;8(1):67-71.
1986: Ronald A Lubet; R W Nims; E Kiss; R E Kouri; D L Putman; L M Schechtman
Influence of various parameters on benzo(a)pyrene enhancement of adenovirus SA7 transformation of Syrian hamster embryo cells.
Environmental mutagenesis 1986;8(4):533-42.
1986: G G Hatch; T M Anderson; Ronald A Lubet; R E Kouri; D L Putman; J W Cameron; R W Nims; B Most; J W Spalding; R W Tennant
Chemical enhancement of SA7 virus transformation of hamster embryo cells: evaluation by interlaboratory testing of diverse chemicals.
Environmental mutagenesis 1986;8(4):515-31.
1986: L M Schechtman; G G Hatch; T M Anderson; D L Putman; R E Kouri; J W Cameron; R W Nims; J W Spalding; R W Tennant; Ronald A Lubet
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
Environmental mutagenesis 1986;8(4):495-514.
1986: Ronald A Lubet; J T McCarvill; J L Schwartz; D L Putman; L M Schechtman
Effects of 3-aminobenzamide on the induction of morphologic transformation by diverse compounds in Balb/3T3 cells in vitro.
Carcinogenesis 1986;7(1):71-5.
1985: Ronald A Lubet; R T Mayer; J W Cameron; R W Nims; M D Burke; T Wolff; F P Guengerich
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.
Archives of biochemistry and biophysics 1985;238(1):43-8.
1985: Ronald A Lubet; R W Nims; R T Mayer; J W Cameron; L M Schechtman
Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol.
Mutation research 1985;142(3):127-31.
1985: G G Hatch; T M Anderson; Ronald A Lubet; R W Nims; L M Schechtman; J W Spalding; R W Tennant
Chemical enhancement of SA7 virus transformation of hamster embryo cells: interlaboratory testing of diverse chemicals.
Carcinogenesis; a comprehensive survey 1985;9():437-47.
1984: Ronald A Lubet; J T McCarvill; D L Putman; J L Schwartz; L M Schechtman
Effect of 3-aminobenzamide on the induction of toxicity and transformation by ethyl methanesulfonate and methylcholanthrene in BALB/3T3 cells.
Carcinogenesis 1984;5(4):459-62.
1983: Ronald A Lubet; E Kiss; M M Gallagher; C Dively; R E Kouri; L M Schechtman
Induction of neoplastic transformation and DNA single-strand breaks in C3H/10T1/2 clone 8 cells by polycyclic hydrocarbons and alkylating agents.
Journal of the National Cancer Institute 1983;71(5):991-7.