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Torben Lübke

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K Kollmann; Torben Lübke; S Markmann; J-C Michalski; W Morelle; Sandra Pohl; A K Röchert; Michaela Schweizer; Steven U Walkley; M Damme; I Hermans-Borgmeyer; Reijo Kakela; Thomas Braulke
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Björn Kowalewski; William C Lamanna; Roger Lawrence; Torben Lübke; Renate Lüllmann-Rauch; Michael Padva; Stijn Stroobants; Markus Damme; Rudi D'Hooge; Jeffrey D Esko; Marc-André Frese; Ina Kalus; Thomas Dierks
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.
Georgia Makrypidi; Sven Müller-Loennies; Paul Saftig; Hartmut Schlüter; Bernhard Schmidt; Maria Trusch; Markus Damme; Joerg Heeren; Torben Lübke; Thomas Braulke
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.

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All Publications

2012: K Kollmann; Torben Lübke; S Markmann; J-C Michalski; W Morelle; Sandra Pohl; A K Röchert; Michaela Schweizer; Steven U Walkley; M Damme; I Hermans-Borgmeyer; Reijo Kakela; Thomas Braulke
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Brain : a journal of neurology 2012;135(Pt 9):2661-75.
2012: Björn Kowalewski; William C Lamanna; Roger Lawrence; Torben Lübke; Renate Lüllmann-Rauch; Michael Padva; Stijn Stroobants; Markus Damme; Rudi D'Hooge; Jeffrey D Esko; Marc-André Frese; Ina Kalus; Thomas Dierks
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10310-5.
2012: Georgia Makrypidi; Sven Müller-Loennies; Paul Saftig; Hartmut Schlüter; Bernhard Schmidt; Maria Trusch; Markus Damme; Joerg Heeren; Torben Lübke; Thomas Braulke
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Molecular and cellular biology 2012;32(4):774-82.
2011: Lalu Rudyat Telly Savalas; Christian Wrocklage; Markus Damme; Cécile Debacker; Bruno Gasnier; Andrej Hasilik; Adrien Jézégou; Torben Lübke; Thomas Reinheckel; Paul Saftig; Bernd Schröder
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
The Biochemical journal 2011;439(1):113-28.
2011: Markus Damme; Stijn Stroobants; Steven U Walkley; Renate Lüllmann-Rauch; Rudi D'Hooge; Jens Fogh; Paul Saftig; Torben Lübke; Judith Blanz
Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis.
Journal of neuropathology and experimental neurology 2011;70(1):83-94.
2010: Markus Damme; Willy Morelle; Bernhard Schmidt; Claes Andersson; Jens Fogh; Jean-Claude Michalski; Torben Lübke
Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.
Molecular and cellular biology 2010;30(1):273-83.
2009: Oliver Schieweck; Markus Damme; Bernd Schröder; Andrej Hasilik; Bernhard Schmidt; Torben Lübke
NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.
The Biochemical journal 2009;422(1):83-90.
2009: Torben Lübke; Peter Lobel; David E Sleat
Proteomics of the lysosome.
Biochimica et biophysica acta 2009;1793(4):625-35.
2009: Kristina Lakomek; Achim Dickmanns; Uwe Mueller; Katrin Kollmann; Florian Deuschl; Annette Berndt; Torben Lübke; Ralf Ficner
De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 3):220-8.
2009: Katrin Kollmann; Markus Damme; Florian Deuschl; Jörg Kahle; Rudi D'Hooge; Renate Lüllmann-Rauch; Torben Lübke
Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1.
The FEBS journal 2009;276(5):1356-69.
2009: Kristina Lakomek; Achim Dickmanns; Matthias Kettwig; Henning Urlaub; Ralf Ficner; Torben Lübke
Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography.
BMC structural biology 2009;9():56.
2007: Christina C Hellbusch; Markus Sperandio; David Frommhold; Sviatlana Yakubenia; Martin K Wild; Diana Popovici; Dietmar Vestweber; Hermann-Josef Gröne; Kurt von Figura; Torben Lübke; Christian Körner
Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II.
The Journal of biological chemistry 2007;282(14):10762-72.
2006: Florian Deuschl; Katrin Kollmann; Kurt von Figura; Torben Lübke
Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distribution.
FEBS letters 2006;580(24):5747-52.
2006: Christian Thiel; Torben Lübke; Gert Matthijs; Kurt von Figura; Christian Körner
Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality.
Molecular and cellular biology 2006;26(15):5615-20.
2005: Katrin Kollmann; Kudzai E Mutenda; Martina Balleininger; Ellen Eckermann; Kurt von Figura; Bernhard Schmidt; Torben Lübke
Identification of novel lysosomal matrix proteins by proteome analysis.
Proteomics 2005;5(15):3966-78.
2002: Dieter Hartmann; Bart De Strooper; Lutgarde Serneels; Katleen Craessaerts; An Herreman; Willem ANNAERT; Lieve Umans; Torben Lübke; Anna Lena Illert; Kurt von Figura; Paul Saftig
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Human molecular genetics 2002;11(21):2615-24.
2002: Bengt Hansske; Christian Thiel; Torben Lübke; Martin Hasilik; Stefan Höning; Verena Peters; Peter H Heidemann; Georg F Hoffmann; Eric G Berger; Kurt von Figura; Christian Körner
Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId.
The Journal of clinical investigation 2002;109(6):725-33.
2001: Torben Lübke; Thorsten Marquardt; A Etzioni; E Hartmann; Kurt von Figura; Christian Körner
Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.
Nature genetics 2001;28(1):73-6.
1999: Torben Lübke; Thorsten Marquardt; Kurt von Figura; Christian Körner
A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi.
The Journal of biological chemistry 1999;274(37):25986-9.