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Jacek Lubkowski

Research Profile

Procedures

X Ray Crystallography

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Living Beings

Escherichia coli

Physiology

Protein Folding

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Publications

TOP 3
Marzena Pazgier; Henryk Szmacinski; Gang Wei; Zhibin Wu; Weirong Yuan; Erik de Leeuw; Bryan Ericksen; Grace Jung; Robert I Lehrer; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.
J Tykvart; C Bařinka; T Knedlík; Jacek Lubkowski; Pavel Sacha; J Starková; Jan Konvalinka
Efficient and versatile one-step affinity purification of in vivo biotinylated proteins: expression, characterization and structure analysis of recombinant human glutamate carboxypeptidase II.
Anna Plechanovová; Martin G Pomper; Lubomír Rulíšek; L'ubica Skultétyová; Glenda Alquicer; Youngjoo Byun; Hyung-Joon Kim; Jan Konvalinka; Jacek Lubkowski; RONNIE MEASE; Petra Mlčochová; Michal Navrátil; Adriana Němcová; Cyril Bařinka
Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity.

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All Publications

2012: Marzena Pazgier; Henryk Szmacinski; Gang Wei; Zhibin Wu; Weirong Yuan; Erik de Leeuw; Bryan Ericksen; Grace Jung; Robert I Lehrer; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide.
The Journal of biological chemistry 2012;287(12):8944-53.
2012: J Tykvart; C Bařinka; T Knedlík; Jacek Lubkowski; Pavel Sacha; J Starková; Jan Konvalinka
Efficient and versatile one-step affinity purification of in vivo biotinylated proteins: expression, characterization and structure analysis of recombinant human glutamate carboxypeptidase II.
Protein expression and purification 2012;82(1):106-15.
2011: Anna Plechanovová; Martin G Pomper; Lubomír Rulíšek; L'ubica Skultétyová; Glenda Alquicer; Youngjoo Byun; Hyung-Joon Kim; Jan Konvalinka; Jacek Lubkowski; RONNIE MEASE; Petra Mlčochová; Michal Navrátil; Adriana Němcová; Cyril Bařinka
Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity.
Journal of medicinal chemistry 2011;54(21):7535-46.
2011: Mi Li; Frank Dimaio; Dongwen Zhou; Alla Gustchina; Jacek Lubkowski; Zbigniew Dauter; David Baker; Alexander Wlodawer
Crystal structure of XMRV protease differs from the structures of other retropepsins.
Nature structural & molecular biology 2011;18(2):227-9.
2011: Oleg Chertov; Ning Zhang; Xin Chen; Joost J Oppenheim; Jacek Lubkowski; Connor McGrath; Raymond C Sowder; Bruce J Crise; Anatoli Malyguine; Michele A Kutzler; Amber D Steele; Earl E Henderson; Thomas J Rogers
Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture.
PloS one 2011;6(1):e14474.
2010: Andrew X Zhang; Ryan P Murelli; Cyril Barinka; Julien Michel; Alexandra Cocleaza; William L Jorgensen; Jacek Lubkowski; David A Spiegel
A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules.
Journal of the American Chemical Society 2010;132(36):12711-6.
2010: Alexander Wlodawer; Jacek Lubkowski; Wladek Minor; Mariusz Jaskolski
Is too 'creative' language acceptable in crystallography?
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 9):1041-2.
2010: Jessica Morales; Karina Villa; Jim Gattis; William Castro; Katiria Colon; Jacek Lubkowski; Priscilla Sanabria; Robert Hunter; A Valance Washington
Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2010;21(3):229-36.
2010: Yuan Zhang; Tim Doherty; Jing Li; Wuyuan Lu; Cyril Barinka; Jacek Lubkowski; Mei Hong
Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR.
Journal of molecular biology 2010;397(2):408-22.
2010: Haofan Wang; Youngjoo Byun; Cyril Barinka; Mrudula Pullambhatla; Hyo-Eun C Bhang; James J Fox; Jacek Lubkowski; RONNIE MEASE; Martin G Pomper
Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies.
Bioorganic & medicinal chemistry letters 2010;20(1):392-7.
2009: Klara Hlouchova; Cyril Barinka; Jan Konvalinka; Jacek Lubkowski
Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.
The FEBS journal 2009;276(16):4448-62.
2009: A Valance Washington; Sébastien Gibot; Ismael Acevedo; James Gattis; Laura Quigley; Robert Feltz; Alina De La Mota; Rebecca L Schubert; Julio Gomez-Rodriguez; Jun Cheng; Amalia Dutra; Evgenia Pak; Oleg Chertov; Linette Rivera; Jessica Morales; Jacek Lubkowski; Robert Hunter; Pamela L Schwartzberg; Daniel W McVicar
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.
The Journal of clinical investigation 2009;119(6):1489-501.
2009: Vojtech Klusák; Cyril Barinka; Anna Plechanovová; Petra Mlcochová; Jan Konvalinka; Lubomír Rulísek; Jacek Lubkowski
Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.
Biochemistry 2009;48(19):4126-38.
2008: Guozhang Zou; Erik de Leeuw; Jacek Lubkowski; Wuyuan Lu
Molecular determinants for the interaction of human neutrophil alpha defensin 1 with its propeptide.
Journal of molecular biology 2008;381(5):1281-91.
2008: Mohsen Rajabi; Erik de Leeuw; Marzena Pazgier; Jing Li; Jacek Lubkowski; Wuyuan Lu
The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability.
The Journal of biological chemistry 2008;283(31):21509-18.
2008: Cyril Barinka; Klara Hlouchova; Miroslava Rovenska; Pavel Majer; Miroslawa Dauter; Niyada Hin; Yao-Sen Ko; Takashi Tsukamoto; Barbara Slusher; Jan Konvalinka; Jacek Lubkowski
Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.
Journal of molecular biology 2008;376(5):1438-50.
2008: Cyril Barinka; Adam Prahl; Jacek Lubkowski
Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 3):273-8.
2007: Cyril Barinka; Miroslava Rovenská; Petra Mlcochová; Klára Hlouchová; Anna Plechanovová; Pavel Majer; Takashi Tsukamoto; Barbara Slusher; Jan Konvalinka; Jacek Lubkowski
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
Journal of medicinal chemistry 2007;50(14):3267-73.
2007: Guozhang Zou; Erik de Leeuw; Chong Li; Marzena Pazgier; Changqing Li; Pengyun Zeng; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
The Journal of biological chemistry 2007;282(27):19653-65.
2007: Zhibin Wu; Xiangqun Li; Bryan Ericksen; Erik de Leeuw; Guozhang Zou; Pengyun Zeng; Cao Xie; Chong Li; Jacek Lubkowski; Wei-Yue Lu; Wuyuan Lu
Impact of pro segments on the folding and function of human neutrophil alpha-defensins.
Journal of molecular biology 2007;368(2):537-49.
2007: Cyril Barinka; Jana Starkova; Jan Konvalinka; Jacek Lubkowski
A high-resolution structure of ligand-free human glutamate carboxypeptidase II.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):150-3.
2007: Marzena Pazgier; Adam Prahl; David M Hoover; Jacek Lubkowski
Studies of the biological properties of human beta-defensin 1.
The Journal of biological chemistry 2007;282(3):1819-29.
2007: Marzena Pazgier; Xiangqun Li; Wuyuan Lu; Jacek Lubkowski
Human defensins: synthesis and structural properties.
Current pharmaceutical design 2007;13(30):3096-118.
2006: Agnieszka Szyk; Zhibin Wu; Kenneth Tucker; De Yang; Wuyuan Lu; Jacek Lubkowski
Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Protein science : a publication of the Protein Society 2006;15(12):2749-60.
2006: Cyril Barinka; Graham Parry; Jennifer Callahan; David E Shaw; Alice Kuo; Khalil Bdeir; Douglas B Cines; Andrew P Mazar; Jacek Lubkowski
Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
Journal of molecular biology 2006;363(2):482-95.
2006: Marzena Pazgier; Jacek Lubkowski
Expression and purification of recombinant human alpha-defensins in Escherichia coli.
Protein expression and purification 2006;49(1):1-8.
2006: Marzena Pazgier; David M Hoover; De Yang; Wuyuan Lu; Jacek Lubkowski
Human beta-defensins.
Cellular and molecular life sciences : CMLS 2006;63(11):1294-313.
2006: James L Gattis; A Valance Washington; Maia M Chisholm; Laura Quigley; Agnieszka Szyk; Daniel W McVicar; Jacek Lubkowski
The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.
The Journal of biological chemistry 2006;281(19):13396-403.
2006: Christopher B Buck; Patricia M Day; Cynthia D Thompson; Jacek Lubkowski; Wuyuan Lu; Douglas Lowy; John T Schiller
Human alpha-defensins block papillomavirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1516-21.
2005: Matina Economopoulou; Khalil Bdeir; Douglas B Cines; Franz Fogt; Yasmina Bdeir; Jacek Lubkowski; Wuyuan Lu; Klaus T Preissner; Hans-Peter Hammes; Triantafyllos Chavakis
Inhibition of pathologic retinal neovascularization by alpha-defensins.
Blood 2005;106(12):3831-8.
2005: Cao Xie; Adam Prahl; Bryan Ericksen; Zhibin Wu; Pengyun Zeng; Xiangqun Li; Wei-Yue Lu; Jacek Lubkowski; Wuyuan Lu
Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
The Journal of biological chemistry 2005;280(38):32921-9.
2005: Zhibin Wu; Fiorenza Cocchi; David Gentles; Bryan Ericksen; Jacek Lubkowski; Anthony DeVico; Robert I Lehrer; Wuyuan Lu
Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.
FEBS letters 2005;579(1):162-6.
2004: Zhibin Wu; Bryan Ericksen; K Tucker; Jacek Lubkowski; Wuyuan Lu
Synthesis and characterization of human alpha-defensins 4-6.
The journal of peptide research : official journal of the American Peptide Society 2004;64(3):118-25.
2004: Zhibin Wu; Jerry Alexandratos; Bryan Ericksen; Jacek Lubkowski; Robert C Gallo; Wuyuan Lu
Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11587-92.
2004: Adam Prahl; Marzena Pazgier; Mahdi Hejazi; Wolfgang Lockau; Jacek Lubkowski
Structure of the isoaspartyl peptidase with L-asparaginase activity from Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1173-6.
2004: Agnieszka Szyk; Wuyuan Lu; Chenqi Xu; Jacek Lubkowski
Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur.
Journal of structural biology 2004;145(3):289-94.
2004: De Yang; Arya Biragyn; David M Hoover; Jacek Lubkowski; Joost J Oppenheim
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
Annual review of immunology 2004;22():181-215.
2003: De Yang; Qian Chen; David M Hoover; Patricia Staley; Kenneth D Tucker; Jacek Lubkowski; Joost J Oppenheim
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
Journal of leukocyte biology 2003;74(3):448-55.
2003: David M Hoover; Zhibin Wu; Kenneth Tucker; Wuyuan Lu; Jacek Lubkowski
Antimicrobial characterization of human beta-defensin 3 derivatives.
Antimicrobial agents and chemotherapy 2003;47(9):2804-9.
2003: Zhibin Wu; Adam Prahl; Robert Powell; Bryan Ericksen; Jacek Lubkowski; Wuyuan Lu
From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain.
The journal of peptide research : official journal of the American Peptide Society 2003;62(2):53-62.
2003: Zhibin Wu; David M Hoover; De Yang; Cyril Boulegue; Fanny Santamaria; Joost J Oppenheim; Jacek Lubkowski; Wuyuan Lu
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8880-5.
2003: Oluwatoyin A Asojo; Cyril Boulegue; David M Hoover; Wuyuan Lu; Jacek Lubkowski
Structures of thymus and activation-regulated chemokine (TARC).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1165-73.
2003: Oluwatoyin A Asojo; Simon Cater; David M Hoover; Cyril Boulegue; Wuyuan Lu; Jacek Lubkowski
Crystallization and preliminary X-ray studies of thymus and activation-regulated chemokine (TARC).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):163-5.
2003: Jacek Lubkowski; Miroslawa Dauter; Khosrow Aghaiypour; Alexander Wlodawer; Zbigniew Dauter
Atomic resolution structure of Erwinia chrysanthemi L-asparaginase.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):84-92.
2002: David M Hoover; Cyril Boulegue; De Yang; Joost J Oppenheim; Kenneth Tucker; Wuyuan Lu; Jacek Lubkowski
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
The Journal of biological chemistry 2002;277(40):37647-54.
2002: David M Hoover; Jacek Lubkowski
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis.
Nucleic acids research 2002;30(10):e43.
2001: Khosrow Aghaiypour; Alexander Wlodawer; Jacek Lubkowski
Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu?
Biochimica et biophysica acta 2001;1550(2):117-28.
2001: David M Hoover; O Chertov; Jacek Lubkowski
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.
The Journal of biological chemistry 2001;276(42):39021-6.
2001: Khosrow Aghaiypour; Alexander Wlodawer; Jacek Lubkowski
Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase.
Biochemistry 2001;40(19):5655-64.
2000: David M Hoover; K R Rajashankar; R Blumenthal; A Puri; Joost J Oppenheim; O Chertov; Jacek Lubkowski
The structure of human beta-defensin-2 shows evidence of higher order oligomerization.
The Journal of biological chemistry 2000;275(42):32911-8.
2000: David M Hoover; LS Mizoue; Tracy M Handel; Jacek Lubkowski
The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.
The Journal of biological chemistry 2000;275(30):23187-93.
1999: Jacek Lubkowski; Z Dauter; F Yang; Jerry Alexandratos; George Merkel; Anna Marie Skalka; Alexander Wlodawer
Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant.
Biochemistry 1999;38(41):13512-22.
1999: Jacek Lubkowski; F Hennecke; A Plückthun; Alexander Wlodawer
Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.
Structure (London, England : 1993) 1999;7(6):711-22.
1999: Jacek Lubkowski; Alexander Wlodawer
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):335-7.
1998: Jacek Lubkowski; F Yang; Jerry Alexandratos; George Merkel; Richard Katz; K Gravuer; Anna Marie Skalka; Alexander Wlodawer
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
The Journal of biological chemistry 1998;273(49):32685-9.
1998: Jukka Kervinen; Jacek Lubkowski; Alexander Zdanov; D Bhatt; Ben M Dunn; K Y Hui; David J Powell; John Kay; Alexander Wlodawer; Alla Gustchina
Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein science : a publication of the Protein Society 1998;7(11):2314-23.
1998: Jacek Lubkowski; F Yang; Jerry Alexandratos; Alexander Wlodawer; H Zhao; T R Burke; N Neamati; Y Pommier; George Merkel; Anna Marie Skalka
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4831-6.
1998: Jacek Lubkowski; F Hennecke; A Plückthun; Alexander Wlodawer
The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p.
Nature structural biology 1998;5(2):140-7.
1997: Gary S Laco; C Schalk-Hihi; Jacek Lubkowski; G Morris; Alexander Zdanov; A Olson; John H Elder; Alexander Wlodawer; Alla Gustchina
Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry 1997;36(35):10696-708.
1997: Zygmunt Gryczynski; S Beretta; Jacek Lubkowski; A Razynska; Ignacy Gryczynski; Enrico Bucci
Time-resolved fluorescence of hemoglobin species.
Biophysical chemistry 1997;64(1-3):81-91.
1997: Zygmunt Gryczynski; Jacek Lubkowski; Enrico Bucci
Intrinsic fluorescence of hemoglobins and myoglobins.
Methods in enzymology 1997;278():538-69.
1997: Jacek Lubkowski; G Bujacz; L Boqué; Peter J Domaille; Tracy M Handel; Alexander Wlodawer
The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions.
Nature structural biology 1997;4(1):64-9.
1996: M Miller; Jacek Lubkowski; J K Rao; A T Danishefsky; James G. Omichinski; K Sakaguchi; H Sakamoto; E Appella; A M Gronenborn; G M Clore
The oligomerization domain of p53: crystal structure of the trigonal form.
FEBS letters 1996;399(1-2):166-70.
1996: Jacek Lubkowski; G J Palm; Gary L Gilliland; Christian Derst; Klaus-Heinrich Röhm; Alexander Wlodawer
Crystal structure and amino acid sequence of Wolinella succinogenes L-asparaginase.
European journal of biochemistry / FEBS 1996;241(1):201-7.
1996: G J Palm; Jacek Lubkowski; Christian Derst; S Schleper; Klaus-Heinrich Röhm; Alexander Wlodawer
A covalently bound catalytic intermediate in Escherichia coli asparaginase: crystal structure of a Thr-89-Val mutant.
FEBS letters 1996;390(2):211-6.
1995: Zygmunt Gryczynski; Jacek Lubkowski; Enrico Bucci
Heme-protein interactions in horse heart myoglobin at neutral pH and exposed to acid investigated by time-resolved fluorescence in the pico- to nanosecond time range.
The Journal of biological chemistry 1995;270(33):19232-7.
1995: Alexander Wlodawer; Alla Gustchina; L Reshetnikova; Jacek Lubkowski; Alexander Zdanov; K Y Hui; E L Angleton; William G Farmerie; Maureen M Goodenow; D Bhatt
Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus.
Nature structural biology 1995;2(6):480-8.
1994: Jacek Lubkowski; Alexander Wlodawer; D Housset; Irene T Weber; H L Ammon; K C Murphy; A L Swain
Refined crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 6):826-32.
1994: Jacek Lubkowski; Alexander Wlodawer; H L Ammon; T D Copeland; A L Swain
Structural characterization of Pseudomonas 7A glutaminase-asparaginase.
Biochemistry 1994;33(34):10257-65.